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https://www.readbyqxmd.com/read/28544984/histo-blood-group-antigens-as-mediators-of-infections
#1
REVIEW
Julie E Heggelund, Annabelle Varrot, Anne Imberty, Ute Krengel
The critical first step of a microbial infection is usually the attachment of pathogens to host cell glycans. Targets on host tissues are in particular the histo-blood group antigens (HBGAs), which are present in rich diversity in the mucus layer and on the underlying mucosa. Recent structural and functional studies have revealed significant new insight into the molecular mechanisms, explaining why individuals with certain blood groups are at increased risk of some infections. The most prominent example of blood-group-associated diseases is cholera, caused by infection with Vibrio cholerae...
May 22, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28544960/anti-biofilm-effect-of-dihydromyricetin-loaded-nanocapsules-on-urinary-catheter-infected-by-pseudomonas-aeruginosa
#2
A J F Dalcin, C G Santos, S S Gündel, I Roggia, R P Raffin, A F Ourique, R C V Santos, P Gomes
Nosocomial infections associated with biofilm formation on urinary catheters are among the leading causes of complications due to biofilm characteristics and high antimicrobial resistance. An interesting alternative are natural products, such as Dihydromyricetin (DMY), a flavonoid which presents several pharmacological properties, including strong antimicrobial activity against various microorganisms. However, DMY, has low aqueous solubility and consequently low bioavailability. Nanoencapsulation can contribute to the improvement of characteristics of some drugs, by increasing the apparent solubility and sustained release has been reported among other advantages...
May 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544922/efficacy-of-benzalkonium-chloride-against-bioluminescent-p-aeruginosa-atcc9027-constructs
#3
N Shah, D C Naseby
Whole cell biosensors have been seldom used in the pharmaceutical and cosmetics industries for preservative efficacy testing (PET). According to several pharmacopoeias, preservatives should be tested for microbial activity using traditional viable count techniques; the use of whole cell microbial biosensors potentially provides an alternative, fast, and efficient method. The aim of the study was to assess the applicability of Pseudomonas aeruginosa ATCC9027 and its validated bioluminescent strains for preservative efficacy tests using benzalkonium chloride (BKC)...
April 23, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28544761/composites-of-bacterial-cellulose-and-small-molecule-decorated-gold-nanoparticles-for-treating-gram-negative-bacteria-infected-wounds
#4
Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544628/production-of-microbial-biosurfactants-status-quo-of-rhamnolipid-and-surfactin-towards-large-scale-production
#5
Marius Henkel, Mareen Geissler, Fabiola Weggenmann, Rudolf Hausmann
Surfactants are an important class of industrial chemicals. Nowadays oleochemical surfactants such as alkyl polyglycosides (APGs) become increasingly important. This trend towards the utilization of renewable resources continues and consumers increasingly demand for environmentally friendly products. Consequently, research in microbial surfactants has drastically increased in the last years. While for mannosylerythritol lipids and sophorolipids established industrial processes exist, an implementation of other microbially derived surfactants has not yet been achieved...
May 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28544570/relative-susceptibility-of-airway-organisms-to-antimicrobial-effects-of-nitric-oxide
#6
Alan D Workman, Ryan M Carey, Michael A Kohanski, David W Kennedy, James N Palmer, Nithin D Adappa, Noam A Cohen
BACKGROUND: Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathogens to NO at physiologic concentrations. In this study we evaluated the effects of NO on 4 common airway bacteria and 1 fungus, and examined the potential implications of discrepancies in sensitivity...
May 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544140/investigation-of-bronchiectasis-in-severe-uncontrolled-asthma
#7
Katerina Dimakou, Anna Gousiou, Michail Toumbis, Maria Kaponi, Serafeim Chrysikos, Loukas Thanos, Christina Triantafillidou
INTRODUCTION: The presence of bronchiectasis in patients with asthma varies in different reports, while a clear etiological relation has not been precisely established. OBJECTIVES: To investigate the presence of bronchiectasis in patients with severe uncontrolled asthma and examine whether they contribute to the severity of asthma. METHODS: Patients with severe asthma were prospectively recruited. HRCT of the chest was performed to identify and grade bronchiectasis using the "Smith" radiology scale...
May 24, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28543603/silver-nanoparticles-antimicrobial-activity-cytotoxicity-and-synergism-with-n-acetyl-cysteine
#8
Selwan Hamed, Mohamed Emara, Riham M Shawky, Ramadan A El-Domany, Tareq Youssef
The fast progression of nanotechnology has led to novel therapeutic interventions. Antimicrobial activities of silver nanoparticles (Ag NPs) were tested against standard ATCC strains of Staphylococcus aureus (ATCC 9144), Escherichia coli (O157:H7), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 90028) in addition to 60 clinical isolates collected from cancer patients. Antimicrobial activity was tested by disk diffusion method and MIC values for Ag NPs alone and in combination with N-acetylcysteine (NAC) against tested pathogens were determined by broth microdilution method...
May 22, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28542616/regulation-of-acetyl-coa-synthetase-transcription-by-the-crbs-r-two-component-system-is-conserved-in-genetically-diverse-environmental-pathogens
#9
Kristin Jacob, Anna Rasmussen, Paul Tyler, Mariah M Servos, Mariame Sylla, Cecilia Prado, Elizabeth Daniele, Josh S Sharp, Alexandra E Purdy
The CrbS/R two-component signal transduction system is a conserved regulatory mechanism through which specific Gram-negative bacteria control acetate flux into primary metabolic pathways. CrbS/R governs expression of acetyl-CoA synthase (acsA), an enzyme that converts acetate to acetyl-CoA, a metabolite at the nexus of the cell's most important energy-harvesting and biosynthetic reactions. During infection, bacteria can utilize this system to hijack host acetate metabolism and alter the course of colonization and pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28542449/specific-expression-and-function-of-the-a-type-cytochrome-c-oxidase-under-starvation-conditions-in-pseudomonas-aeruginosa
#10
Tatsuya Osamura, Takuro Kawakami, Reiko Kido, Masaharu Ishii, Hiroyuki Arai
Pseudomonas aeruginosa has one A-type (caa3) and multiple C-type (cbb3) cytochrome c oxidases as well as two quinol oxidases for aerobic respiration. The caa3 oxidase is highly efficient in creating a proton gradient across the cell membrane, but it is not expressed under normal growth conditions and its physiological role has not been investigated. In the present study, a mutant strain deficient in the coxBA-PA0107-coxC genes encoding caa3 exhibited normal growth under any test conditions, but it had low relative fitness under carbon starvation conditions, indicating that the expression of caa3 is advantageous under starvation conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28541480/alternative-evolutionary-paths-to-bacterial-antibiotic-resistance-cause-distinct-collateral-effects
#11
C Barbosa, V Trebosc, C Kemmer, P Rosenstiel, R Beardmore, H Schulenburg, G Jansen
When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral sensitivity may be exploited to develop novel, sustainable antibiotic treatment strategies aimed at containing the current, dramatic spread of drug resistance. To date, the presence and molecular basis of collateral sensitivity has only been studied in few bacterial species and is unknown for opportunistic human pathogens such as Pseudomonas aeruginosa. In the present study, we assessed patterns of collateral effects by experimentally evolving 160 independent populations of P...
May 23, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28540585/antibiofilm-activity-and-mode-of-action-of-dmso-alone-and-its-combination-with-afatinib-against-gram-negative-pathogens
#12
Mohd Fakharul Zaman Raja Yahya, Zazali Alias, Saiful Anuar Karsani
Biofilms are complex microbial communities that tend to attach to either biotic or abiotic surface. Enclosed in a self-produced extracellular polymeric substance (EPS) matrix, the biofilms often cause persistent infections. The objective of this study was to investigate the antibiofilm activity of dimethyl sulfoxide (DMSO) and afatinib against Gram-negative pathogens. Test microorganisms used in this study were Escherichia coli ATCC 1299, Pseudomonas aeruginosa ATCC 10145, and Salmonella typhimurium ATCC 14028...
May 24, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28540556/the-use-of-bacterial-bioremediation-of-metals-in-aquatic-environments-in-the-twenty-first-century-a-systematic-review
#13
Feliphe Lacerda Souza de Alencar, Julio Alejandro Navoni, Viviane Souza do Amaral
Metal pollution is a current environmental issue as a consequence of unregulated anthropic activiy. A wide range of bioremediation strategies have been successfully implemented to recover contaminated areas. Among them, bacterial bioremediation stands out as a promising tool to confront these types of concerns. This study aimed to compare and discuss worldwide scientific evolution of bacterial potential for metal bioremediation in aquatic ecosystems. The study consisted of a systematic review, elaborated through a conceptual hypothesis model, during the period from 2000 to 2016, using PubMed, MEDLINE, and SciELO databases as data resources...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28539745/effect-of-tamarindus-indica-l-and-manihot-esculenta-extracts-on-antibiotic-resistant-bacteria
#14
Zenon Machado Lima, Lenilson Santos da Trindade, Genelane Cruz Santana, Francine Ferreira Padilha, Marcelo da Costa Mendonça, Luiz Pereira da Costa, Jorge A López, Maria Lucila Hernández Macedo
BACKGROUND: The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. OBJECTIVE: The aim of the present study was to evaluate the hydroethanolic leaf extracts of Tamarindus indica (tamarind) and Manihot esculenta (cassava) as antimicrobial potential against Pseudomonas aeruginosa clinical isolated and Methicillin-resistant Staphylococcus aureus...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539728/anti-quorum-sensing-activity-of-forsythia-suspense-on-chromobacterium-violaceum-and-pseudomonas-aeruginosa
#15
An Zhang, Wei-Hua Chu
BACKGROUND: Quorum sensing (QS) plays an important role in the production of virulence factors and pathogenicity in Pseudomonas aeruginosa, and the interruption of QS will be a hopeful pathway to combat bacterial infection. OBJECTIVE: In this study, we selected Forsythia suspense (Thunb.) Vahl from traditional Chinese herbal medicines for its anti-QS activity. MATERIALS AND METHODS: Anti-QS of F. suspense extracts (FSE) was monitored using the Chromobacterium violaceum 12472 bioassay...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539095/effectiveness-of-non-fluoride-and-fluoride-dentifrices-for-denture-hygiene
#16
Gökçe Meriç, Meryem Güvenir, Kaya Suer
OBJECTIVE: To compare the effectiveness of commonly used herbal/non-fluoride with fluoride dentifrices in order to eliminate pathogenic oral microorganisms from denture base material. MATERIALS AND METHODS: Heat-polymerized acrylic resin specimens (n = 288) were divided into three groups and each group inoculated with three various microorganisms (n = 96 for each) Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa (P. aeruginosa). Contaminated specimens were randomly assigned to the application of six herbal/non-fluoride and three fluoride dentifrices...
May 24, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28538851/-antimicrobial-sensitivity-of-the-environmental-microbiota-in-the-intensive-care-units-of-a-peruvian-hospital
#17
José Díaz-Tello, Jesús Rojas-Jaimes, Jimmy Ibarra-Trujillo, Delza Tárraga-Gonzales
The objective was to detect Gram-negative bacilli and Gram-positive cocci isolated from the environmental microbiota of the Intensive Care Unit (ICU) departments of Neonatology, Pediatrics, and Transplants (kidney, liver, and general) in a Lima hospital and determine their antimicrobial sensitivity. Eighty samples were obtained from inanimate surfaces using a wet swab. A total of 61 bacterial strains were identified, including Staphylococcus epidermis (46.0%), Alcaligenes sp. (21.3%), Pseudomonas aeruginosa (16...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538846/-clinical-and-microbiological-study-of-catheter-associated-urinary-tract-infections-in-internal-medicine-services-of-a-venezuelan-university-hospital
#18
Pedro Quijada-Martínez, Ana Flores-Carrero, Indira Labrador, María Araque
Objectives: To determine the clinical and microbiological characteristics of catheter-associated urinary tract infections (CA-UTI) in patients admitted to the Internal Medicine services of the Hospital Universitario de Los Andes (HULA), Mérida, Venezuela and to establish the clonal distribution of multi-resistant Enterobacteriaceae that produce this infection. Materials and Methods: Seventy-three adult patients with bladder catheterization were studied between January and July 2015...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28537028/enhanced-larvicidal-antibacterial-and-photocatalytic-efficacy-of-tio2-nanohybrids-green-synthesized-using-the-aqueous-leaf-extract-of-parthenium-hysterophorus
#19
Keerthika Thandapani, Manikandan Kathiravan, Elangovan Namasivayam, Indira Arulselvi Padiksan, Geetha Natesan, Manish Tiwari, Benelli Giovanni, Venkatachalam Perumal
Titanium dioxide nanoparticles are emerging as a biocompatible nanomaterial with multipurpose bioactivities. In this study, titanium dioxide (TiO2) nanoparticles were effectively synthesized using the aqueous leaf extracts of Parthenium hysterophorus prepared by microwave irradiation. TiO2 nanoparticles were fabricated by treating the P. hysterophorus leaf extracts with the TiO4 solution. Biologically active compounds such as alcohols, phenols, alkanes, and fluoroalkanes were involved in bioreduction of TiO4 into TiO2...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28536384/in-vitro-anti-oxidant-and-anti-microbial-potentiality-investigation-of-different-fractions-of-caryota-urens-leaves
#20
Shofiul Azam, Md Kayes Mahmud, Md Hamza Naquib, Saad Mosharraf Hossain, Mohammad Nazmul Alam, Md Josim Uddin, Irfan Sajid, Muhammad Sazzad Hossain, Md Salimul Karim, Md Ali Hasan
BACKGROUND: Caryota urens is a member of the Arecaceae family and a common plant in the Southeast Asian region. This plant has been reported as an anti-microbial agent in recent years. Thus, we aimed to find out the MIC (minimum inhibitory concentration) against different pathogenic microorganism. METHODS: The leaves of C. urens were extracted and fractioned using different reagents (chloroform, n-hexane and carbon tetrachloride). Disc diffusion method was implemented for the assessment of in vitro anti-microbial potency (500 and 250 µg/disc)...
July 27, 2016: Biomedicines
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