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https://www.readbyqxmd.com/read/29156846/s100a14-rs11548103-g-a-polymorphism-is-associated-with-a-decreased-risk-of-esophageal-cancer-in-a-chinese-population
#1
Yang Zhao, Feng Yao, Weifeng Tang, Haiyong Gu, Heng Zhao
Objective: In China in 2009, esophageal cancer was the fifth most commonly diagnosed malignancy and the fourth leading cause of malignancy-related death. Accumulating evidence indicates that genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. Materials and Methods: In total, we recruited 629 ESCC patients and 686 controls. Genetic variations in the S100A14, MLH1, SMAD7 and CCL22/MDC genes were measured using the ligation detection reaction method...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156845/metastatic-to-negative-lymph-node-ratio-demonstrates-significant-prognostic-value-in-patients-with-esophageal-squamous-cell-carcinoma-after-esophagectomy
#2
Xiao-Feng Duan, Peng Tang, Xiao-Bin Shang, Hong-Jing Jiang, Zhen-Tao Yu
Aims: The prognostic value of metastatic lymph node ratio (LNR) has been reported in some studies; however, there is no report on the prognostic significance of metastatic to negative lymph node ratio (MNLNR) in cancer patients. The aim of this study was to compare the prognostic value of pN, LNR and MNLNR on the survival of patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy. Methods: The data of 290 patients with ESCC after curative esophagectomy was retrospectively analyzed...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156844/a-three-microrna-signature-for-lung-squamous-cell-carcinoma-diagnosis-in-chinese-male-patients
#3
Lan Zhang, Xia Shan, Jun Wang, Jun Zhu, Zebo Huang, Huo Zhang, Xin Zhou, Wenfang Cheng, Yongqian Shu, Wei Zhu, Ping Liu
Various studies have demonstrated the diagnostic value of microRNA (miRNA) for lung cancer, but miRNA signatures varied between different subtypes. Whether serum miRNAs could be used as biomarkers in lung squamous cell carcinoma (SCC) remains unknown. Using quantitative real-time polymerase chain reaction (qRT-PCR) based Exiqon panel, 38 differentially expressed miRNAs were identified from 3 male lung SCC pool samples and 1 normal control (NC) pool in the initial screening phase. After the training (24 SCC VS...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156829/mdm4-genetic-variants-predict-hpv16-positive-tumors-of-patients-with-squamous-cell-carcinoma-of-the-oropharynx
#4
Zhongming Lu, Hua Zhang, Ye Tao, Xiangping Li, Guojun Li
The increasing incidence of squamous cell carcinoma of the oropharynx (SCCOP) is majorly attributed to the human papillomavirus (HPV) infection. Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. Three polymorphisms in MDM4 were genotyped from blood genomic DNA samples and HPV16 status in tumor specimens was examined. Odds ratio (OR) and 95% confidence intervals (CIs) in univariate and multivariable logistic regression models were calculated for the associations between these polymorphisms and HPV16 status...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156804/hotair-regulates-hk2-expression-by-binding-endogenous-mir-125-and-mir-143-in-oesophageal-squamous-cell-carcinoma-progression
#5
Jian Ma, Yanxin Fan, Tingting Feng, Fangjun Chen, Zhipeng Xu, Suqing Li, Qingfeng Lin, Xiaoting He, Weihong Shi, Yang Liu, Xiufeng Cao, Bin Zhu, Zhihua Liu
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156802/efficacy-and-safety-of-first-line-pemetrexed-plus-carboplatin-followed-by-single-agent-pemetrexed-maintenance-in-elderly-chinese-patients-with-non-squamous-non-small-cell-lung-cancer
#6
Xinmin Zhao, Hui Yu, Jing Zhao, Xianghua Wu, Si Sun, Zhiguo Luo, Huijie Wang, Jie Qiao, Jianhua Chang, Jialei Wang
Chemotherapy with pemetrexed plus carboplatin followed by pemetrexed maintenance therapy is a first-line regimen for patients with advanced non-squamous non-small-cell lung cancer. This phase II clinical study investigated the efficacy and safety of this regimen in older patients (aged ≥65 years) with advanced non-squamous non-small-cell lung cancer. All patients received 4 courses of induction therapy with pemetrexed (500 mg/m(2)) combined with carboplatin once every 3 weeks. If patients had stable disease or achieved a complete or partial tumor response after 4 courses of pemetrexed + carboplatin therapy, maintenance treatment with pemetrexed monotherapy was administered until either disease progression or intolerable toxicity occurred...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156801/genomic-characterization-of-human-papillomavirus-positive-and-negative-human-squamous-cell-cancer-cell-lines
#7
Nene N Kalu, Tuhina Mazumdar, Shaohua Peng, Li Shen, Vaishnavi Sambandam, Xiayu Rao, Yuanxin Xi, Lerong Li, Yuan Qi, Frederico O Gleber-Netto, Ameeta Patel, Jing Wang, Mitchell J Frederick, Jeffrey N Myers, Curtis R Pickering, Faye M Johnson
Human cancer cell lines are the most frequently used preclinical models in the study of cancer biology and the development of therapeutics. Although anatomically diverse, human papillomavirus (HPV)-driven cancers have a common etiology and similar mutations that overlap with but are distinct from those found in HPV-negative cancers. Building on prior studies that have characterized subsets of head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESC) cell lines separately, we performed genomic, viral gene expression, and viral integration analyses on 74 cell lines that include all readily-available HPV-positive (9 HNSCC, 8 CESC) and CESC (8 HPV-positive, 2 HPV-negative) cell lines and 55 HPV-negative HNSCC cell lines...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156763/elas1-induces-apoptotic-death-in-adenocarcinoma-du145-and-squamous-cell-carcinoma-sas-cancer-cells-but-not-in-normal-kd-cells
#8
Toshihiro Uchihashi, Kaori Ota, Yusuke Yabuno, Shouichi Ohno, Kohshiro Fukushima, Yoko Naito, Mikihiko Kogo, Norikazu Yabuta, Hiroshi Nojima
We previously reported that an ELAS1 peptide containing 29 amino acids induces apoptotic death in U2OS human osteosarcoma cells following DNA double-strand break insults. Here, we show that ELAS1 also caused apoptosis in prostate adenocarcinoma DU145 cells and tongue squamous-cell carcinoma SAS cells. ELAS1 appears to be safe because it induced apoptosis only in cancer cells, not in normal KD cells. Because the effect of ELAS1 is dependent on increased stability of p53 and enhanced phosphorylation of p53-S46, we exogenously expressed wild-type p53 protein to fully promote ELAS1-mediated induction of apoptosis in SAS cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156759/smoking-and-gender-modify-the-effect-of-twist-on-patient-survival-in-head-and-neck-squamous-carcinoma
#9
Yun Zhu, Wenjuan Zhang, Ping Wang
Purpose: TWIST is a critical factor for predicting prognosis in several human cancers. Here, we study the prognostic significance of TWIST1 and TWIST2 in Head and Neck squamous cell carcinoma (HNSCC) as well as interactions of TWISTs with both gender and smoking in patient survival. Methods: upper quartile normalized RNA-seq V2 RSEM values of TWIST1 and TWIST2 expressions were retrieved from a TCGA HNSCC dataset. Kaplan-Meier survival curves were used to assess the associations of TWIST1 and TWIST2 with patient survival, and multivariate Cox proportional hazards regression models were used to estimate the hazards ratios (HRs) and their 95% confidence intervals (CIs)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156735/telomerase-reverse-transcriptase-mediates-emt-through-nf-%C3%AE%C2%BAb-signaling-in-tongue-squamous-cell-carcinoma
#10
Yan Wu, Chunxiang Bian, Chunlin Zhen, Liu Liu, Zhenghong Lin, Muhammad Farrukh Nisar, Mei Wang, Jörg W Bartsch, Enyi Huang, Ping Ji, Li Yang, Yanhong Yu, Junfeng Yang, Xuemei Jiang, Julia Li Zhong
Locoregional lymph nodes metastasis in oral tongue squamous cell carcinoma represents one of important and common prognostic factors for poor clinical outcome. The human Telomerase Reverse Transcriptase (hTERT) is one of key players in cancer metastasis and stemness, but its exact function in tongue squamous cell carcinoma remains unknown. Here, we aim to understand the role of hTERT by utilizing the CRISPR/Cas9 gene editing system to deplete hTERT in the SCC-15 cell line. Functional comparison of SCC-15 control and knockout cells (hTERT(-/-)) showed that loss of hTERT suppressed cell proliferation and migration/invasion...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156713/the-prognostic-impact-of-overall-treatment-time-on-disease-outcome-in-uterine-cervical-cancer-patients-treated-primarily-with-concomitant-chemoradiotherapy-a-nationwide-taiwanese-cohort-study
#11
Shih-Min Lin, Hsiu-Ying Ku, Ting-Chang Chang, Tsang-Wu Liu, Ji-Hong Hong
The importance of the overall treatment time (OTT) has a paradoxical status in the current era of concomitant chemoradiotherapy. The main objective of this nationwide study was to evaluate the correlation between overall treatment duration and clinical outcome in cervical cancer patients treated primarily with curative concurrent chemoradiotherapy (CCRT). In this population-based cohort study, 2,594 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I-IVA uterine cervical cancer were studied...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156523/cancer-associated-%C3%AF-broblasts-confer-cisplatin-resistance-of-tongue-cancer-via-autophagy-activation
#12
Juan-Kun Liao, Bin Zhou, Xiu-Mei Zhuang, Pei-Lin Zhuang, Da-Ming Zhang, Wei-Liang Chen
Cancer-associated fibroblasts (CAFs) play important roles in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC). However, effect of CAFs on chemotherapy resistance of TSCC remains largely obscure. Here, we cultured the matched primary CAFs and normal fibroblasts (NFs) pairs and detected their roles in cisplatin sensitivity of TSCC, as well as autophagy-related protein LC3 and Beclin1 expressions. During exposure to cisplatin, TSCC with CAFs group exhibited significantly increased cell viability and IC50, but reduced apoptosis than that with NFs group...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156447/pd-1-blockade-in-advanced-nsclc-a-focus-on-pembrolizumab
#13
REVIEW
Solange Peters, Keith M Kerr, Rolf Stahel
Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers and is responsible for a large proportion of all cancer-related deaths. Current treatment options are inadequate, reflecting a substantial unmet clinical need. Increasing knowledge regarding the mechanisms and genetic aberrations underlying tumor development and growth has heralded a new era of therapy in oncology, moving away from indiscriminate cytotoxic chemotherapy toward more finely focused, targeted medicine. The development of small-molecule drugs and monoclonal antibodies directed toward specific components of dysfunctional molecular or immune pathways, and mutated genes specific to particular cancer types, is leading the field to more personalized and less toxic treatment options, many of which have demonstrated greater efficacy and survival benefits than their chemotherapeutic counterparts...
October 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29156232/use-of-negative-pressure-wound-therapy-after-infection-and-flap-dehiscence-in-radical-vulvectomy-a-case-report
#14
Antoni Llueca, Jose Luis Herraiz, Raquel Del Moral, Dolors Piquer, Yasmine Maazouzi, Blanca Segarra, Jordan Barres, Anna Serra
INTRODUCTION: Vulvar cancer has a lower incidence in high income countries, but is rising, in part, due to the high life expectancy in these societies. Radical vulvectomy is still the standard treatment in initial stages. Wound dehiscence contitututes one of the most common postoperative complications. PRESENTATION OF CASE: A 76year old patient with a squamous cell carcinoma of the vulva, FIGO staged, IIIb is presented. Radical vulvectomy and bilateral inguinal lymph node dissection with lotus petal flaps reconstruction are performed as the first treatment...
November 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29155864/supraglottic-squamous-cell-carcinomas-have-distinctive-clinical-features-and-prognosis-based-on-subregion
#15
Weiquan Ding, Tianrun Liu, Jiangang Liang, Tingbao Hu, Shaoyun Cui, Guorong Zou, Weiwei Cai, Ankui Yang
OBJECTIVE: To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions. METHODS: Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization...
2017: PloS One
https://www.readbyqxmd.com/read/29155185/video-endoscopic-inguinal-lymphadenectomy-versus-open-inguinal-lymphadenectomy-for-carcinoma-penis-expanding-role-and-comparison-of-outcomes
#16
S S Yadav, V Tomar, R Bhattar, A K Jha, S Priyadarshi
OBJECTIVE: To compare differences of morbidity profile, oncological yield & efficacy between video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy cases. MATERIALS AND METHODS: A total of 29 patients with proven squamous cell carcinoma of penis were selected for inguinal lymphadenectomy from August 2013 to Jan 2017. Video endoscopic lymphadenectomy was performed on one limb and open inguinal lymphadenectomy was performed on the contralateral side...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29154973/inhibition-of-bmp-signaling-overcomes-acquired-resistance-to-cetuximab-in-oral-squamous-cell-carcinomas
#17
Jinlong Yin, Ji-Eun Jung, Sun Il Choi, Sung Soo Kim, Young Taek Oh, Tae-Hoon Kim, Eunji Choi, Sun Joo Lee, Hana Kim, Eun Ok Kim, Yu Sun Lee, Hee Jin Chang, Joo Yong Park, Yeejeong Kim, Tak Yun, Kyun Heo, Youn-Jae Kim, Hyunggee Kim, Yun-Hee Kim, Jong Bae Park, Sung Weon Choi
Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response to cetuximab and ultimately develop drug resistance. However, mechanism underlying cetuximab resistance in OSCC is not clearly understood. Here, using a mouse orthotopic xenograft model of OSCC, we show that BMP7-p-Smad1/5/8 signaling contributes to cetuximab resistance. Tumor cells isolated from the recurrent cetuximab-resistant xenograft models exhibited low EGFR expression but extremely high levels of phosphorylated Smad-1, -5, and -8 (p-Smad1/5/8)...
November 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29154871/association-between-genetic-polymorphisms-in-the-promoters-of-let-7-and-risk-of-cervical-squamous-cell-carcinoma
#18
Jing Liu, Shanshan Ni
Numerous reports showed low levels of let-7 family in cervical cancer, acting as tumor suppressors by regulating multiple target genes. Genetic variants in the promoter of miRNA have been reported to influence individuals' susceptibility to human diseases. We aimed to investigate the association of rs10877887 and rs13293512 polymorphisms in the promoters of let-7 with risk of cervical squamous cell carcinoma (CSCC). A total of 331 patients with CSCC and 358 controls were included. Genotyping of rs10877887 was done using polymerase chain reaction-restriction fragment length polymorphism analysis...
November 14, 2017: Gene
https://www.readbyqxmd.com/read/29154820/cytotoxic-t-cell-responses-to-streptococcus-are-associated-with-improved-prognosis-of-oral-squamous-cell-carcinoma
#19
Jie Wang, Feng Sun, Xiaoyu Lin, Zaiye Li, Xiaohe Mao, Canhua Jiang
Several species of Streptococcus, such as S. salivarius, S. mitis, and S. anginosus, are found to extensively colonize the oral cavity and the upper respiratory tract, and have been shown to increase in patients with oral squamous cell carcinoma (OSCC). Accumulating evidence have revealed that commensal bacteria are involved in antitumor immunity via T cell-mediated mechanisms, but the role of Streptococcus enrichment in OSCC is yet unclear. In this study, we stimulated peripheral blood mononuclear cells from non-cancer controls (NCs) and OSCC patients with S...
November 14, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#20
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
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