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https://www.readbyqxmd.com/read/28938686/incidence-and-clearance-of-oral-human-papillomavirus-infection-a-population-based-cohort-study-in-rural-china
#1
Chaoting Zhang, Fangfang Liu, Yaqi Pan, Qiuju Deng, Xiang Li, Zhonghu He, Mengfei Liu, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938652/correlation-between-apparent-diffusion-coefficient-adc-and-cellularity-is-different-in-several-tumors-a-meta-analysis
#2
Alexey Surov, Hans Jonas Meyer, Andreas Wienke
The purpose of this meta-analysis was to provide clinical evidence regarding relationship between ADC and cellularity in different tumors based on large patient data. Medline library was screened for associations between ADC and cell count in different tumors up to September 2016. Only publications in English were extracted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) was used for the research. Overall, 39 publications with 1530 patients were included into the analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938638/prognostic-modeling-of-oral-cancer-by-gene-profiles-and-clinicopathological-co-variables
#3
Steven W Mes, Dennis Te Beest, Tito Poli, Silvia Rossi, Kathrin Scheckenbach, Wessel N van Wieringen, Arjen Brink, Nicoletta Bertani, Davide Lanfranco, Enrico M Silini, Paul J van Diest, Elisabeth Bloemena, C René Leemans, Mark A van de Wiel, Ruud H Brakenhoff
Accurate staging and outcome prediction is a major problem in clinical management of oral cancer patients, hampering high precision treatment and adjuvant therapy planning. Here, we have built and validated multivariable models that integrate gene signatures with clinical and pathological variables to improve staging and survival prediction of patients with oral squamous cell carcinoma (OSCC). Gene expression profiles from 249 human papillomavirus (HPV)-negative OSCCs were explored to identify a 22-gene lymph node metastasis signature (LNMsig) and a 40-gene overall survival signature (OSsig)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938622/profiling-cancer-related-gene-mutations-in-oral-squamous-cell-carcinoma-from-japanese-patients-by-targeted-amplicon-sequencing
#4
Takafumi Nakagaki, Miyuki Tamura, Kenta Kobashi, Ryota Koyama, Hisayo Fukushima, Tomoko Ohashi, Masashi Idogawa, Kazuhiro Ogi, Hiroyoshi Hiratsuka, Takashi Tokino, Yasushi Sasaki
Somatic mutation analysis is a standard practice in the study of human cancers to identify mutations that cause therapeutic sensitization and resistance. We performed comprehensive genomic analyses that used PCR target enrichment and next-generation sequencing on Ion Proton semiconductor sequencers. Forty-seven oral squamous cell carcinoma (OSCC) samples and their corresponding noncancerous tissues were used for multiplex PCR amplification to obtain targeted coverage of the entire coding regions of 409 cancer-related genes (covered regions: 95...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938617/development-and-validation-of-nomogram-based-on-lncrna-zfas1-for-predicting-survival-in-lymph-node-negative-esophageal-squamous-cell-carcinoma-patients
#5
Hongtai Shi, Zhenhua Liu, Dong Pei, Youqin Jiang, Haiwen Zhu, Bin Chen
BACKGROUND: There is increasing evidence of a relationship between long non-coding RNA (lncRNA) and cancer. This study aimed to examine the prognostic value of the lncRNA ZFAS1 in esophageal squamous cell carcinoma (ESCC). RESULTS: The results showed that ZFAS1 expression was significantly higher in ESCC tissues compared with the corresponding adjacent normal tissues (P < 0.001). ESCC patients with high ZFAS1 expression had a poor overall survival (OS). Histological grade, T stage and ZFAS1 expression were integrated to develop the nomogram...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938579/the-effects-of-air-pollution-on-mortality-and-clinicopathological-features-of-esophageal-cancer
#6
Xiaochen Huang, Shanghui Guan, Jiangfeng Wang, Linli Zhao, Yibin Jia, Zilong Lu, Cuiping Yin, Shengsi Yang, Qingxu Song, Lihui Han, Cong Wang, Jingyi Li, Wei Zhou, Xiaolei Guo, Yufeng Cheng
This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM10), SO2, NO2 and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM10 (p=0.046) and NO2 (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM10 was still an independent risk factor that increased esophageal cancer mortality rates...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938570/pd-l1-expression-as-poor-prognostic-factor-in-patients-with-non-squamous-non-small-cell-lung-cancer
#7
Cuiling Zhou, Jianjun Tang, Huanhuan Sun, Xiaobin Zheng, Zhanyu Li, Tiantian Sun, Jie Li, Shuncong Wang, Xiuling Zhou, Hongliu Sun, Zhibin Cheng, Hongyu Zhang, Haiqing Ma
OBJECTIVES: The role of programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC), especially according to histologic type, remains controversial. The purpose of this study was to assess PD-L1 expression and its association with overall survival (OS) and clinicopathologic characteristics in NSCLC. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded specimens were obtained from 108 patients with surgically resected primary NSCLC. PD-L1 expression was assessed via immunohistochemistry using a histochemistry score system...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938536/integrating-omics-data-and-protein-interaction-networks-to-prioritize-driver-genes-in-cancer
#8
Tiejun Zhang, Di Zhang
Although numerous approaches have been proposed to discern driver from passenger, identification of driver genes remains a critical challenge in the cancer genomics field. Driver genes with low mutated frequency tend to be filtered in cancer research. In addition, the accumulation of different omics data necessitates the development of algorithmic frameworks for nominating putative driver genes. In this study, we presented a novel framework to identify driver genes through integrating multi-omics data such as somatic mutation, gene expression, and copy number alterations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938158/directional-migration-in-esophageal-squamous-cell-carcinoma-escc-is-epigenetically-regulated-by-set-nuclear-oncogene-a-member-of-the-inhibitor-of-histone-acetyltransferase-complex
#9
Xiang Yuan, Xinshuai Wang, Bianli Gu, Yingjian Ma, Yiwen Liu, Man Sun, Jinyu Kong, Wei Sun, Huizhi Wang, Fuyou Zhou, Shegan Gao
Directional cell migration is of fundamental importance to a variety of biological events, including metastasis of malignant cells. Herein, we specifically investigated SET oncoprotein, a subunit of the recently identified inhibitor of acetyltransferases (INHAT) complex and identified its role in the establishment of front-rear cell polarity and directional migration in Esophageal Squamous Cell Carcinoma (ESCC). We further define the molecular circuits that govern these processes by showing that SET modulated DOCK7/RAC1 and cofilin signaling events...
September 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28938010/epidermal-growth-factor-receptor-targeted-sonoporation-with-microbubbles-enhances-therapeutic-efficacy-in-a-squamous-cell-carcinoma-model
#10
Fumika Hirabayashi, Kenjiro Iwanaga, Toshinori Okinaga, Osamu Takahashi, Wataru Ariyoshi, Ryo Suzuki, Mutsumi Sugii, Kazuo Maruyama, Kazuhiro Tominaga, Tatsuji Nishihara
Sonoporation is a drug and gene delivery system using ultrasonication that allows the intracellular delivery of foreign molecules that cannot enter cells under normal conditions. We previously reported that sonoporation with microbubbles (MBs) could achieve effective intracellular drug delivery to human gingival squamous carcinoma Ca9-22 cells. In this study, we developed anti-epidermal growth factor receptor (EGFR) antibody-conjugated MBs (EGFR-MBs) and evaluated their capacity to enhance anti-cancer drug toxicity in vitro and in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28938008/vca-nanobodies-target-n-wasp-to-reduce-invadopodium-formation-and-functioning
#11
Tim Hebbrecht, Isabel Van Audenhove, Olivier Zwaenepoel, Adriaan Verhelle, Jan Gettemans
Invasive cancer cells develop small actin-based protrusions called invadopodia, which perform a primordial role in metastasis and extracellular matrix remodelling. Neural Wiskott-Aldrich syndrome protein (N-WASp) is a scaffold protein which can directly bind to actin monomers and Arp2/3 and is a crucial player in the formation of an invadopodium precursor. Expression modulation has pointed to an important role for N-WASp in invadopodium formation but the role of its C-terminal VCA domain in this process remains unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28937628/integrative-pathway-analysis-of-genes-and-metabolites-reveals-metabolism-abnormal-subpathway-regions-and-modules-in-esophageal-squamous-cell-carcinoma
#12
Chunquan Li, Qiuyu Wang, Jiquan Ma, Shengshu Shi, Xin Chen, Haixiu Yang, Junwei Han
Aberrant metabolism is one of the main driving forces in the initiation and development of ESCC. Both genes and metabolites play important roles in metabolic pathways. Integrative pathway analysis of both genes and metabolites will thus help to interpret the underlying biological phenomena. Here, we performed integrative pathway analysis of gene and metabolite profiles by analyzing six gene expression profiles and seven metabolite profiles of ESCC. Multiple known and novel subpathways associated with ESCC, such as 'beta-Alanine metabolism', were identified via the cooperative use of differential genes, differential metabolites, and their positional importance information in pathways...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937303/palliative-coverage-of-cranial-defect-following-failed-cranial-flap-for-advanced-squamous-cell-carcinoma-case-report
#13
Vyacheslav Makler, Jeffrey S Litt, N Scott Litofsky
INTRODUCTION: With advanced-stage head and neck cancers, patients may develop large and/or complex wounds despite multiple reconstruction attempts. Wound coverage may require novel approaches to palliate the patient. METHOD: We present the case of a 56-year-old female with advanced squamous cell carcinoma of the scalp and skull who required multiple surgical interventions. Despite our best reconstructive efforts, the patient subsequently developed scalp infection and sepsis, necessitating further debridement for source control...
September 22, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28937022/yield-of-p53-expression-in-esophageal-squamous-cell-cancer-and-its-relationship-with-survival
#14
Tushar H Sankalecha, Sudhir J Gupta, Nitin R Gaikwad, Nikhil U Shirole, Harit G Kothari
BACKGROUND/AIMS: Esophageal squamous cell carcinoma (ESCC) is the most aggressive type of cancer. Mutation of tumor suppressor gene p53 is observed in many gastrointestinal malignancies including ESCC. The immunohistochemical protein expression of mutant p53 has been proposed as a potential tool to evaluate the biological behavior of ESCC. Predictive value of p53 for survival is debatable, hence this study was formulated to know the survival of patients with p53 expression in ESCC. PATIENTS AND METHODS: We prospectively included 91 consecutive patients of ESCC from August 2014 to August 2016...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936477/clinical-characteristics-of-non-melanoma-skin-cancers-recurring-within-5-years-after-mohs-micrographic-surgery-single-institution-retrospective-chart-review
#15
Tina Vajdi, Robert Eilers, Shang I Brian Jiang
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases. OBJECTIVE: We examined specific clinical characteristics associated with NMSC recurrences following MMS. METHODS: We employed a retrospective chart review of the 1467 cases of NMSC that underwent MMS at UC San Diego from January 1, 2008 through December 31, 2009...
January 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28936470/porcine-esophageal-submucosal-gland-culture-model-shows-capacity-for-proliferation-and-differentiation
#16
Richard J von Furstenberg, Joy Li, Christina Stolarchuk, Rachel Feder, Alexa Campbell, Leandi Kruger, Liara M Gonzalez, Anthony T Blikslager, Diana M Cardona, Shannon J McCall, Susan J Henning, Katherine S Garman
BACKGROUND & AIMS: Although cells comprising esophageal submucosal glands (ESMGs) represent a potential progenitor cell niche, new models are needed to understand their capacity to proliferate and differentiate. By histologic appearance, ESMGs have been associated with both overlying normal squamous epithelium and columnar epithelium. Our aim was to assess ESMG proliferation and differentiation in a 3-dimensional culture model. METHODS: We evaluated proliferation in human ESMGs from normal and diseased tissue by proliferating cell nuclear antigen immunohistochemistry...
November 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28936296/oral-lymphoepithelial-cyst-a-clinicopathological-study-of-26-cases-and-review-of-the-literature
#17
REVIEW
Maria Sykara, Panagiotis Ntovas, Eleni-Marina Kalogirou, Konstantinos I Tosios, Alexandra Sklavounou
INTRODUCTION: Τo describe the clinicopathological features of 26 oral lymphoepithelial cysts (LECs) and review the literature. MATERIAL AND METHODS: Twenty-six cases of oral LECs diagnosed during a 37-year period were retrospectively collected. The patients' gender and age, as well as the main clinical features of the cysts were retrieved from the requisition forms. The main microscopic features were recorded after reevaluation of all cases. Pubmed and Google Scholar electronic databases were searched with the key word "oral LEC"...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936292/evolution-of-oral-cancer-treatment-in-an-andalusian-population-sample-rehabilitation-with-prosthetic-obturation-and-removable-partial-prosthesis
#18
Rafael Flores-Ruiz, Lizette Castellanos-Cosano, María-Angeles Serrera-Figallo, Aida Gutiérrez-Corrales, Maribel Gonzalez-Martin, Jose-Luis Gutiérrez-Pérez, Daniel Torres-Lagares
BACKGROUND: Radical surgical resection as a treatment modality for oral cancer often leads to an extensive deficit in both the maxillary and mandibular levels, where the use of a palatal obturator prosthesis (POP) or removable partial denture (RPP). The aim of this study was to evaluate the treatment with POP and RPP in patients treated for oral cancer in the Unit of Prosthetic Rehabilitation of the University Hospital Virgen del Rocío in a period of 20 years. MATERIAL AND METHODS: Retrospective descriptive study during the years 1991 and 2011 analyzing oral cancer type, characteristics, treatment and follow-up...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936214/a-mucosal-and-cutaneous-chemokine-ligand-for-the-lymphocyte-chemoattractant-receptor-gpr15
#19
Borja Ocón, Junliang Pan, Theresa Thu Dinh, Wenjing Chen, Romain Ballet, Michael Bscheider, Aida Habtezion, Hua Tu, Brian A Zabel, Eugene C Butcher
Chemoattractants control lymphocyte recruitment from the blood, contributing to the systemic organization of the immune system. The G protein-linked receptor GPR15 mediates lymphocyte homing to the large intestines and skin. Here we show that the 9 kDa CC-motif containing cationic polypeptide AP57/colon-derived sushi containing domain-2 binding factor (CSBF), encoded by C10orf99 in the human and 2610528A11Rik in the mouse, functions as a chemokine ligand for GPR15 (GPR15L). GPR15L binds GPR15 and attracts GPR15-expressing T cells including lymphocytes in colon-draining lymph nodes and Vγ3(+) thymic precursors of dermal epithelial T cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28935563/oridonin-induces-g2-m-cell-cycle-arrest-and-apoptosis-in-human-oral-squamous-cell-carcinoma
#20
Han Wang, Liping Zhu, Xiaodong Feng, Han Zhang, Qingqiong Luo, Fuxiang Chen
Oridonin, an active diterpeniod isolated from Rabdosia rubescens, has been reported for its anti-tumor activity on several cancers, however, its effect on oral squamous cell carcinoma (OSCC) remains unclear. In this study, we demonstrated for the first time that oridonin inhibited the growth of OSCC cells both in vitro and in vivo. Oridonin decreased the proliferation and clonal formation of cultured OSCC cells in a dose-dependent manner. Further study indicated that oridonin induced G2/M phase arrest in OSCC cells, which was associated with the downregulation of proteins related to G2/M transition including cdc25C, cdc2 and cyclin B1, as well as the upregulation of p53 and phosphorylated-cdc2...
September 18, 2017: European Journal of Pharmacology
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