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Hearing loss and cognitive

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https://www.readbyqxmd.com/read/28737048/ototoxicity-monitoring-in-children-treated-with-platinum-chemotherapy
#1
Beth Brooks, Kristin Knight
OBJECTIVE: To review the prevalence, mechanisms, clinical presentation, risk factors and implications of platinum-induced ototoxicity in paediatric cancer patients based on published evidence, discuss options for monitoring hearing in young children during treatment and review long-term follow-up guidelines. DESIGN: Narrative literature review. RESULTS: Children treated with cisplatin are at high risk of hearing loss and early, accurate identification of ototoxicity is important for medical decision making and hearing rehabilitation...
July 24, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28734053/hearing-impairment-and-incident-dementia-findings-from-the-english-longitudinal-study-of-ageing
#2
Hilary R Davies, Dorina Cadar, Annie Herbert, Martin Orrell, Andrew Steptoe
OBJECTIVES: To determine whether hearing loss is associated with incident physician-diagnosed dementia in a representative sample. DESIGN: Retrospective cohort study. SETTING: English Longitudinal Study of Ageing. PARTICIPANTS: Adults aged 50 and older. MEASUREMENTS: Cross-sectional associations between self-reported (n = 7,865) and objective hearing measures (n = 6,902) and dementia were examined using multinomial-logistic regression...
July 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28724467/differential-associations-between-sensory-loss-and-neuropsychiatric-symptoms-in-adults-with-and-without-a-neurocognitive-disorder
#3
Kim M Kiely, Moyra E Mortby, Kaarin J Anstey
BACKGROUND: To investigate the differential associations between sensory loss and neuropsychiatric symptoms among older adults with and without diagnosed neurocognitive disorder. METHODS: The sample comprised 1,393 adults (52.3% men) aged between 72 and 79 years from a community-based cohort study. There were 213 cases of mild and 64 cases of major neurocognitive disorders. The main outcome was number of informant reported symptoms on the Neuropsychiatric Inventory (NPI)...
July 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28710824/a-novel-study-on-association-between-untreated-hearing-loss-and-cognitive-functions-of-older-adults-baseline-non-verbal-cognitive-assessment-results
#4
Dona M P Jayakody, Peter L Friedland, Robert H Eikelboom, Ralph N Martins, Hamid R Sohrabi
BACKGROUND: Age-related hearing loss (ARHL) is highly prevalent in older adults and more than two-thirds above age 70 years suffer from ARHL. Recent studies have established a link between ARHL and cognitive impairment, however, most of the studies have used verbally loaded cognitive measures to investigate the association between ARHL and cognition. It is possible that due to hearing impairment, the elderly may experience difficulty in following verbal instructions or completing tasks that heavily rely on hearing during cognitive assessments...
July 15, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28705608/the-impact-of-hearing-aids-and-age-related-hearing-loss-on-auditory-plasticity-across-three-months-an-electrical-neuroimaging-study
#5
Nathalie Giroud, Ulrike Lemke, Philip Reich, Katarina L Matthes, Martin Meyer
The present study investigates behavioral and electrophysiological auditory and cognitive-related plasticity in three groups of healthy older adults (60-77 years). Group 1 was moderately hearing-impaired, experienced hearing aid users, and fitted with new hearing aids using non-linear frequency compression (NLFC on); Group 2, also moderately hearing-impaired, used the same type of hearing aids but NLFC was switched off during the entire period of study duration (NLFC off); Group 3 represented individuals with age-appropriate hearing (NHO) as controls, who were not different in IQ, gender, or age from Group 1 and 2...
June 29, 2017: Hearing Research
https://www.readbyqxmd.com/read/28688548/eeg-activity-as-an-objective-measure-of-cognitive-load-during-effortful-listening-a-study-on-pediatric-subjects-with-bilateral-asymmetric-sensorineural-hearing-loss
#6
Pasquale Marsella, Alessandro Scorpecci, Giulia Cartocci, Sara Giannantonio, Anton Giulio Maglione, Isotta Venuti, Ambra Brizi, Fabio Babiloni
OBJECTIVES: Deaf subjects with hearing aids or cochlear implants generally find it challenging to understand speech in noisy environments where a great deal of listening effort and cognitive load are invested. In prelingually deaf children, such difficulties may have detrimental consequences on the learning process and, later in life, on academic performance. Despite the importance of such a topic, currently, there is no validated test for the assessment of cognitive load during audiological tasks...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28687057/factors-influencing-speech-perception-in-noise-for-5-year-old-children-using-hearing-aids-or-cochlear-implants
#7
Teresa Yc Ching, Vicky W Zhang, Christopher Flynn, Lauren Burns, Laura Button, Sanna Hou, Karen McGhie, Patricia Van Buynder
OBJECTIVE: We investigated the factors influencing speech perception in babble for 5-year-old children with hearing loss who were using hearing aids (HAs) or cochlear implants (CIs). DESIGN: Speech reception thresholds (SRTs) for 50% correct identification were measured in two conditions - speech collocated with babble, and speech with spatially separated babble. The difference in SRTs between the two conditions give a measure of binaural unmasking, commonly known as spatial release from masking (SRM)...
July 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28686082/providing-dementia-consultations-to-veterans-using-clinical-video-telehealth-results-from-a-clinical-demonstration-project
#8
Stuti Dang, Carlos A Gomez-Orozco, Maria H van Zuilen, Silvina Levis
PURPOSE: Veterans with dementia and their caregivers in remote areas may not have access to specialists to provide diagnosis, treatment, and education. The purpose of this clinical demonstration project was to examine the feasibility, acceptability, and impact of a video consultations clinic for veterans with dementia or memory complaints and their caregivers. METHODS: The dementia clinical video telehealth (CVT) consultation clinic was established to identify, diagnose, and treat dementia in veterans at sites distant from the main medical center...
July 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28679960/preexisting-antibodies-can-protect-against-congenital-cytomegalovirus-infection-in-monkeys
#9
Cody S Nelson, Diana Vera Cruz, Dollnovan Tran, Kristy M Bialas, Lisa Stamper, Huali Wu, Margaret Gilbert, Robert Blair, Xavier Alvarez, Hannah Itell, Meng Chen, Ashlesha Deshpande, Flavia Chiuppesi, Felix Wussow, Don J Diamond, Nathan Vandergrift, Mark R Walter, Peter A Barry, Michael Cohen-Wolkowiez, Katia Koelle, Amitinder Kaur, Sallie R Permar
Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of congenital infection, but does not prevent the disease altogether. We employed a nonhuman primate model of congenital CMV infection to investigate the ability of preexisting antibodies to protect against placental CMV transmission in the setting of primary maternal infection and subsequent viremia, which is required for placental virus exposure...
July 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28672318/effect-of-depth-and-duration-of-cooling-on-death-or-disability-at-age-18-months-among-neonates-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Seetha Shankaran, Abbot R Laptook, Athina Pappas, Scott A McDonald, Abhik Das, Jon E Tyson, Brenda B Poindexter, Kurt Schibler, Edward F Bell, Roy J Heyne, Claudia Pedroza, Rebecca Bara, Krisa P Van Meurs, Carolyn M Petrie Huitema, Cathy Grisby, Uday Devaskar, Richard A Ehrenkranz, Heidi M Harmon, Lina F Chalak, Sara B DeMauro, Meena Garg, Michelle E Hartley-McAndrew, Amir M Khan, Michele C Walsh, Namasivayam Ambalavanan, Jane E Brumbaugh, Kristi L Watterberg, Edward G Shepherd, Shannon E G Hamrick, John Barks, C Michael Cotten, Howard W Kilbride, Rosemary D Higgins
Importance: Hypothermia for 72 hours at 33.5°C for neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. Objective: To determine if cooling for 120 hours or to a temperature of 32.0°C reduces death or disability at age 18 months in infants with hypoxic-ischemic encephalopathy. Design, Setting, and Participants: Randomized 2 × 2 factorial clinical trial in neonates (≥36 weeks' gestation) with hypoxic-ischemic encephalopathy at 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network between October 2010 and January 2016...
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28670275/results-of-an-interdisciplinary-day-care-approach-for-chronic-tinnitus-treatment-a-prospective-study-introducing-the-jena-interdisciplinary-treatment-for-tinnitus
#11
Daniela Ivansic, Christian Dobel, Gerd F Volk, Daniel Reinhardt, Boris Müller, Ulrich C Smolenski, Orlando Guntinas-Lichius
Objective: Considering the heterogeneity of the symptoms shown by patients suffering from chronic tinnitus, there are surprisingly few interdisciplinary treatments available, and mostly available only for inpatients. In order to provide an interdisciplinary treatment, we developed a day care concept in which each patient was treated by an ENT doctor, a cognitive behavioral therapist, a specialist for medical rehabilitation and an audiologist (Jena Interdisciplinary Treatment for Tinnitus, JITT). The aim of this study was to observe the changes of tinnitus related distress due to interdisciplinary day care treatment and to determine which factors mediate this change...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28666708/sound-offset-related-brain-potentials-show-retained-sensory-processing-but-increased-cognitive-control-activity-in-older-adults
#12
János Horváth, Zsófia Anna Gaál, Márta Volosin
It has been hypothesized that age-related hearing loss is caused not only by peripheral but also central changes in the auditory system. Many studies used event-related potentials (ERPs) elicited by sound onsets to characterize the age-related differences in central auditory processing. Age-related ERP enhancements in such studies have often been interpreted in terms of elevated sensitivity to auditory stimulation. Such ERPs, however, comprise various components reflecting different aspects of auditory and task-related processing...
June 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28661962/brain-changes-associated-with-age-related-hearing-loss
#13
Justin S Golub
PURPOSE OF REVIEW: To discuss brain changes associated with age-related hearing loss (ARHL), including cognitive abilities and neuroimaging findings. This information will be helpful to hypothesize and ultimately understand how ARHL may be mechanistically related to changes in brain structure and function. It will also be helpful to guide the strength of treatment recommendations. RECENT FINDINGS: ARHL has recently been associated with cognitive impairment and dementia...
June 28, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28651255/visual-cues-contribute-differentially-to-audiovisual-perception-of-consonants-and-vowels-in-improving-recognition-and-reducing-cognitive-demands-in-listeners-with-hearing-impairment-using-hearing-aids
#14
Shahram Moradi, Björn Lidestam, Henrik Danielsson, Elaine Hoi Ning Ng, Jerker Rönnberg
Purpose: We sought to examine the contribution of visual cues in audiovisual identification of consonants and vowels-in terms of isolation points (the shortest time required for correct identification of a speech stimulus), accuracy, and cognitive demands-in listeners with hearing impairment using hearing aids. Method: The study comprised 199 participants with hearing impairment (mean age = 61.1 years) with bilateral, symmetrical, mild-to-severe sensorineural hearing loss...
June 23, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28650352/the-effect-of-aging-and-priming-on-same-different-judgments-between-text-and-partially-masked-speech
#15
Richard L Freyman, Jenna Terpening, Angela C Costanzi, Karen S Helfer
OBJECTIVES: It is well known from previous research that when listeners are told what they are about to hear before a degraded or partially masked auditory signal is presented, the speech signal "pops out" of the background and becomes considerably more intelligible. The goal of this research was to explore whether this priming effect is as strong in older adults as in younger adults. DESIGN: Fifty-six adults-28 older and 28 younger-listened to "nonsense" sentences spoken by a female talker in the presence of a 2-talker speech masker (also female) or a fluctuating speech-like noise masker at 5 signal-to-noise ratios...
June 22, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28649514/early-hematopoietic-stem-cell-transplantation-in-a-patient-with-severe-mucopolysaccharidosis-ii-a-7%C3%A2-years-follow-up
#16
Anneliese L Barth, Tatiana S P C de Magalhães, Ana Beatriz R Reis, Maria Lucia de Oliveira, Fernanda B Scalco, Nicolette C Cavalcanti, Daniel S E Silva, Danielle A Torres, Alessandra A P Costa, Carmem Bonfim, Roberto Giugliani, Juan C Llerena, Dafne D G Horovitz
Mucopolysaccharidosis type II (MPS II - Hunter syndrome) is an X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2 sulfatase (I2S), leading to the accumulation of the glycosaminoglycans, affecting multiple organs and systems. Enzyme replacement therapy does not cross the blood brain barrier, limiting results in neurological forms of the disease. Another option of treatment for severe MPS, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of MPS type I, since it can preserve neurocognition when performed early in the course of the disease...
September 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28647130/fever-induced-paroxysmal-weakness-and-encephalopathy-a-new-phenotype-of-atp1a3-mutation
#17
Sho T Yano, Kenneth Silver, Richard Young, Suzanne D DeBrosse, Roseànne S Ebel, Kathryn J Swoboda, Gyula Acsadi
BACKGROUND: We identified a group of patients with ATP1A3 mutations at residue 756 who display a new phenotype, distinct from alternating hemiplegia of childhood, rapid-onset dystonia-parkinsonism, and cerebellar ataxia, areflexia, pes cavus, optic atrophy, sensorineural hearing loss syndromes. METHODS: Four patients with c.2267G>A (R756H) mutations from two families and two patients with c.2267G>T (R756L) mutations from one family are described and compared with the previously reported patients with mutations resulting in R756H and R756C protein variants...
April 29, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28607889/outcomes-of-newborn-hearing-screening-program-a-hospital-based-study
#18
Kavita Sachdeva, Tulsi Sao
Hearing loss is hidden disability and second most common congenital pathology. Prevention, early identification and early intervention of hearing loss can prevent further disability in development of speech, language, cognition and other developmental domains. The prevalence of congenital hearing loss has been estimated to be 1.2-5.7 per thousand in neonates. In these contexts, the aim of study was to determine outcomes of neonates hearing screening program in Hospital. It is a clinical cross-sectional study which was conducted in tertiary care centre from 8th July, 2015 to 31th May, 2016...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28604578/long-term-outcomes-of-cochlear-implantation-in-children-with-congenital-cytomegalovirus-infection
#19
Haruo Yoshida, Haruo Takahashi, Yukihiko Kanda, Kyoko Kitaoka, Minoru Hara
OBJECTIVE: To investigate the role of the developmental delay often observed in children with congenital cytomegalovirus (CMV) infection on the improvement of language understanding after cochlear implantation (CI). STUDY DESIGN: Retrospective chart review. PATIENTS: Sixteen children with severe and/or profound hearing loss due to congenital CMV infection (CMV group) and 107 congenitally deaf children (168 ears) without CMV infection as the cause of deafness (non-CMV group)...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28593790/molecular-diagnostics-for-hereditary-hearing-loss-in-children
#20
Manou Sommen, Wim Wuyts, Guy Van Camp
Hearing loss (HL) is the most common birth defect in industrialized countries with far-reaching social, psychological and cognitive implications. It is an extremely heterogeneous disease, complicating molecular testing. The introduction of next-generation sequencing (NGS) has resulted in great progress in diagnostics allowing to study all known HL genes in a single assay. The diagnostic yield is currently still limited, but has the potential to increase substantially. Areas covered: In this review the utility of NGS and the problems for comprehensive molecular testing for HL are evaluated and discussed...
August 2017: Expert Review of Molecular Diagnostics
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