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Lacrimal gland

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https://www.readbyqxmd.com/read/28937867/coenzyme-q10-for-the-protection-of-lacrimal-gland-against-high-dose-radioiodine-therapy-associated-oxidative-damage-histopathologic-and-tissue-cytokine-level-assessments-in-an-animal-model
#1
Mehmet Yakin, Umit Eksioglu, Murat Sadic, Gokhan Koca, Guner Ozkan-Uney, Nihat Yumusak, Hande Husniye Telek, Ayten Demir, Nuray Yazihan, Firdevs Ornek, Meliha Korkmaz
PURPOSE: To evaluate protective effect of coenzyme Q10 (CoQ10) in lacrimal glands against high-dose radioactive iodine (RAI)-associated oxidative damage. MATERIALS AND METHODS: Thirty Wistar albino rats were randomly divided into three groups. Group 1 was the control group. Group 2 received 3 mCi/kg RAI via gastric gavage but no medication. Group 3 received 3 mCi/kg RAI via gastric gavage and 30 mg/kg/day CoQ10 intraperitoneally. CoQ10 was started at day one just before RAI administration and continued for five days...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28926640/aire-deficient-mice-provide-a-model-of-corneal-and-lacrimal-gland-neuropathy-in-sj%C3%A3-gren-s-syndrome
#2
Feeling Y Chen, Albert Lee, Shaokui Ge, Sara Nathan, Sarah M Knox, Nancy A McNamara
Sjögren's syndrome (SS) is a chronic, autoimmune exocrinopathy that leads to severe dryness of the mouth and eyes. Exocrine function is highly regulated by neuronal mechanisms but little is known about the link between chronic inflammation, innervation and altered exocrine function in the diseased eyes and exocrine glands of SS patients. To gain a better understanding of neuronal regulation in the immunopathogenesis of autoimmune exocrinopathy, we profiled a mouse model of spontaneous, autoimmune exocrinopathy that possess key characteristics of peripheral neuropathy experienced by SS patients...
2017: PloS One
https://www.readbyqxmd.com/read/28918184/removal-of-recurrent-intraorbital-tumour-using-a-system-of-augmented-reality
#3
P Scolozzi, P Bijlenga
The most crucial step in the management of pleomorphic adenoma of the lacrimal gland is choosing the optimal approach for excision. We report the successful removal of a recurrent pleomorphic adenoma of the lacrimal gland in a 42-year-old woman using a specific microscope-based system of augmented reality.
September 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28913516/a-rare-erosive-orbital-mass-in-a-child-case-report-of-myofibroma
#4
Bahram Eshraghi, Shima Dehghani, Ghasem Saeedi-Anari
PURPOSE: To present the clinical, histological, and radiographic findings of a case of orbital myofibroma in an unusual location. The literature is reviewed and the clinical relevance discussed. METHODS: A 5-year-old boy was examined with a 1.5-month history of progressive swelling in the left supraorbital region. RESULTS: Examination revealed a firm, painless mass in the supralateral region of the left orbit with slight reddish discoloration of the overlying skin...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28905841/lacrimal-gland-myxoma
#5
Drushti Parikh, Bipasha Mukherjee
Myxomas are rare neoplasms of mesenchymal origin. Cases of conjunctival, corneal, and orbital myxomas have been reported in the literature; however, to the best of our knowledge, there is no report of a lacrimal gland myxoma. We report a case of an orbital myxoma involving the lacrimal gland and its management.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903405/uptake-of-psma-ligands-in-normal-tissues-is-dependent-on-tumor-load-in-patients-with-prostate-cancer
#6
Florian C Gaertner, Khalil Halabi, Hojjat Ahmadzadehfar, Stefan Kürpig, Elisabeth Eppard, Charalambos Kotsikopoulos, Nikolaos Liakos, Ralph A Bundschuh, Holger Strunk, Markus Essler
Radioligand therapy (RLT) with Lu-177-labeled PSMA-ligands is a new therapy option for prostate cancer. Biodistribution in normal tissues is of interest for therapy planning. We evaluated if the biodistribution of Ga-68-PSMA-11 is influenced by tumor load. RESULTS: In patients with high tumor load, SUVmean was reduced to 61.5% in the lacrimal glands, to 56.6% in the parotid glands, to 63.7% in the submandibular glands, to 61.3% in the sublingual glands and to 55.4% in the kidneys (p < 0...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902875/interferon-%C3%AE-treatment-in-vitro-elicits-some-of-the-changes-in-cathepsin-s-and-antigen-presentation-characteristic-of-lacrimal-glands-and-corneas-from-the-nod-mouse-model-of-sj%C3%A3-gren-s-syndrome
#7
Zhen Meng, Wannita Klinngam, Maria C Edman, Sarah F Hamm-Alvarez
Inflammation and impaired secretion by lacrimal and salivary glands are hallmarks of the autoimmune disease, Sjögren's Syndrome. These changes in the lacrimal gland promote dryness and inflammation of the ocular surface, causing pain, irritation and corneal damage. The changes that initiate and sustain autoimmune inflammation in the lacrimal gland are not well-established. Here we demonstrate that interferon-γ (IFN-γ) is significantly elevated in lacrimal gland and tears of the male NOD mouse, a model of autoimmune dacryoadenitis which exhibits many ocular characteristics of Sjögren's Syndrome, by 12 weeks of age early in lacrimal gland inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28889800/adenocarcinoma-of-the-lacrimal-gland-a-case-report
#8
Asmae Touil, Sarah El Abbassi, Yassine Echchikhi, Mustapha Maher, Tayeb Kebdani, Noureddine Benjaafar
BACKGROUND: Primary ductal adenocarcinomas of the lacrimal gland are very rare. This neoplasm shares some histological and immunohistochemical similarities with salivary duct carcinoma. CASE PRESENTATION: Here, we present a case of a 55-year-old Moroccan man with lacrimal gland adenocarcinoma. He underwent orbital exenteration with lymph nodes dissection and ipsilateral parotidectomy. After surgery, he was lost to follow-up and died 13 months later. CONCLUSIONS: Lacrimal gland tumors are rare but highly aggressive salivary gland tumors...
September 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28880986/association-of-disease-location-and-treatment-with-survival-in-diffuse-large-b-cell-lymphoma-of-the-eye-and-ocular-adnexal-region
#9
Aseef H Ahmed, C Stephen Foster, Carol L Shields
Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database...
September 7, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28879904/a-neurosurgical-perspective-to-approaches-to-the-orbit-a-cadaveric-study
#10
S Balaji Pai, M N Nagarjun
Neurosurgeons are getting increasingly involved in surgery for orbital tumours. The various approaches to the orbit can be challenging. The authors have demonstrated on cadavers the various approaches to the orbit which are required to be mastered by the neurosurgeon. The superior approaches which include the transcranial, supraorbital and the hybrid approaches are the most commonly utilized surgical approaches by the neurosurgeon for excision of orbital pathologies. The lateral orbitotomy is an elegant approach for excision of the tumours lateral to the optic Nerve and lacrimal gland tumours...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28874911/a-ligation-of-the-lacrimal-excretory-duct-in-mouse-induces-lacrimal-gland-inflammation-with-proliferative-cells
#11
Ying Liu, Masatoshi Hirayama, Tetsuya Kawakita, Kazuo Tsubota
The lacrimal gland secretes tear fluids to ocular surface, which plays an indispensable role in maintaining the health of the ocular epithelia and protecting the ocular surface from the external environment. The dysfunction of the lacrimal glands causes dry eye disease due to a reduction in tear volume. The dry eye disease is becoming a popular public disease, for the number of patients is increasing, who have subjective symptom and loss of vision, which affect the quality of life. Inflammatory change in the damaged lacrimal gland has been reported; however, a major challenge is to establish a simple animal model to observe the changes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28871434/cutaneous-and-mucosal-manifestations-of-sj%C3%A3-gren-s-syndrome
#12
REVIEW
Elena Generali, Antonio Costanzo, Carlo Mainetti, Carlo Selmi
Sjögren's syndrome is currently considered an "autoimmune epithelitis," as exocrine glands, especially salivary and lacrimal, are progressively destructed by an immune-mediated process associated with specific serum autoantibodies and local lymphocyte infiltrate. Xerostomia remains a key complain in patients with Sjögren's syndrome but should be evaluated also for other causes such as xerogenic medications, followed by radiation and chemotherapy for head and neck cancers, hormone disorders, infections, or other connective tissue diseases...
September 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28870031/-the-clinical-characteristics-of-346-patients-with-igg4-related-disease
#13
P P Zhang, J Z Zhao, M Wang, R E Feng, X W Liu, X M Lai, X J Li, J G Zeng, H J Shi, H D Zhu, W Xue, H Zhang, Y Y Chen, L Y Fei, X F Peng, F C Zeng, Y M Zhang, W Zhang
Objective: To analyze the clinical characteristics of IgG4-related disease (IgG4-RD)so as to improve the understanding of IgG4-RD in China. Methods: IgG4-RD patients were recruited from Peking Union Medical College Hospital between January 2011 and January 2016. All patients were followed-up for more than 6 months. The demographic characteristics, symptoms, organ involvements, laboratory examinations and treatment efficacy were evaluated and analyzed. Results: A total of 346 patients were finally enrolled, including 230 males (66...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28868280/optic-disc-pyogenic-granuloma
#14
Eduardo F Marback, Luciano Espinheira Fonseca, Roberto L Marback
AIM: The aim of this paper was to report a rare presentation of adenoid cystic carcinoma. METHOD: This is a case report presenting clinical, radiographic, and histopathologic findings. RESULTS: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with adenoid cystic carcinoma. She was then referred to the ophthalmology service, where ocular examination demonstrated 2...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28862467/clinical-imaging-and-laboratory-findings-in-sj%C3%A3-gren-s-syndrome
#15
Aruanda Fiche, Alynne Vieira Menezes, Claudia Scigliano Valerio, Martinho Campolina Rebello Horta, Flávio Ricardo Manzi
Sjögren's syndrome (SS) is a rare condition characterized by structural damage and secretory dysfunction of the lacrimal and salivary glands that leads to dryness, particularly xerophthalmia (eyes) and xerostomia (mouth). No cure is known; however, the effects of the disease are manageable and symptoms may be reduced. Although the salivary damage is irreversible, the dental decay and oral infections may be prevented, which highlights the importance that the clinician plays in the diagnosis and management of SS...
September 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28861590/-botulinum-toxin-in-otorhinolaryngology-an-update
#16
R Laskawi, A Olthoff
During recent decades, the clinical use of botulinum toxin has become increasingly well established. In the field of otorhinolaryngology there are many indications for which botulinum toxin can improve patients' quality of life. These include applications in the region of the head and neck muscles and the autonomic nervous system in patients suffering from movement disorders of special muscles and secretory disorders (salivary, lacrimal, and sweat glands). The present article presents an overview of well-established and new indications for application of botulinum toxin in the head and neck region...
August 31, 2017: HNO
https://www.readbyqxmd.com/read/28861347/association-of-the-macrophage-migration-inhibitory-factor-promoter-polymorphisms-with-benign-lymphoepithelial-lesion-of-lacrimal-gland
#17
Qin-Jian Li, Peng-Xiang Zhao, Xu-Juan Zhang, Yang Yi, Dan-Ying Cheng, Jian-Min Ma, Xue-Mei Ma
AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G>C and STR -794 CATT(5-8) polymorphism, respectively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860914/ectopic-lacrimal-gland-in-a-complex-choristoma-involving-the-lacrimal-sac-fossa
#18
Mohammad Javed Ali, Dilip Kumar Mishra, Milind N Naik
Complex choristomas involving the lacrimal drainage system are not common. Ectopic lacrimal gland within complex choristomas has been described in the eyelid and orbit. We describe a pediatric case of complex choristoma with ectopic lacrimal gland involving the lacrimal sac fossa and partly the medial eyelid and orbit along with a brief review of literature.
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28860327/lacrimal-gland-and-extensive-subcutaneous-tissue-involvement-by-mantle-cell-lymphoma
#19
Iman Khodarahmi, Nasrin Ghesani
No abstract text is available yet for this article.
August 31, 2017: Blood
https://www.readbyqxmd.com/read/28858963/igg4-related-disease-in-the-eye-and-ocular-adnexa
#20
Larissa Derzko-Dzulynsky
PURPOSE OF REVIEW: IgG4-related disease is a relatively newly described, multiorgan, fibro-inflammatory disease with characteristic histopathology showing lymphoplasmacytic infiltration and increased IgG4+ plasma cells and elevated IgG4/IgG ratios (>40%). The lacrimal gland is the most common ocular site of involvement. Scleritis and intraocular involvement in IgG4-related ophthalmic disease (IgG4-ROD) have recently been reported. The purpose of this review is to describe orbital and intraocular IgG4-ROD with a focus on publications since 2016...
August 30, 2017: Current Opinion in Ophthalmology
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