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Lacrimal gland

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https://www.readbyqxmd.com/read/27911431/-o%C3%B1-umethyl-in-the-treatment-of-allergic-diseases-of-eyelids-and-conjunctiva
#1
N R Marchenko
Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27906544/lfa-1-icam-1-interaction-as-a-therapeutic-target-in-dry-eye-disease
#2
Stephen C Pflugfelder, Michael Stern, Steven Zhang, Amir Shojaei
Dry eye disease (DED) is a common ocular disorder associated with inflammation of the lacrimal gland and ocular surface. The interaction of the integrin lymphocyte function-associated antigen-1 (LFA-1) with its cognate ligand intercellular adhesion molecule-1 (ICAM-1) is known to have important roles in the interaction of a variety of cells involved in immune responses and inflammation, including those prominent in ocular surface inflammation. Lifitegrast, an LFA-1 antagonist that blocks binding of ICAM-1 to LFA-1, has recently been approved in the United States for the treatment of signs and symptoms of DED...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27904918/-diagnosis-and-treatment-of-the-watering-eye
#3
M Schargus, G Geerling
The wet eye is a common symptom that ophthalmologists as well as otorhinolaryngolists are confronted with. The causes can be diverse, affecting all parts from the lacrimal gland to the lacrimal drainage system. Frequently tear film changes are the reason for the symptoms, which may vary from classic epiphora and impaired vision to tear film instability with damage of the corneal epithelium. The knowledge and understanding of the underlying pathologies and differential diagnosis is crucial in order to initiate adequate therapy and to avoid overtreating with invasive surgical means...
November 30, 2016: HNO
https://www.readbyqxmd.com/read/27898620/intra-arterial-chemotherapy-for-lacrimal-gland-adenoid-cystic-carcinoma
#4
Matthew Zhang, Cherie Fathy, Mark P Breazzano, Matthew Hollar, Behin Barahimi
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27886047/topical-application-of-apricot-kernel-extract-improves-dry-eye-symptoms-in-a-unilateral-exorbital-lacrimal-gland-excision-mouse
#5
Chan-Sik Kim, Kyuhyung Jo, Ik-Soo Lee, Junghyun Kim
The purpose of this study was to investigate the therapeutic effects of topical application of apricot kernel extract (AKE) in a unilateral exorbital lacrimal gland excision mouse model of experimental dry eye. Dry eye was induced by surgical removal of the lacrimal gland. Eye drops containing 0.5 or 1 mg/mL AKE were administered twice a day from day 3 to day 7 after surgery. Tear fluid volume and corneal irregularity scores were determined. In addition, we examined the immunohistochemical expression level of Muc4...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27879057/direct-visualization-of-aqueous-tear-secretion-from-lacrimal-gland
#6
Eun Chul Kim, Sang Hee Doh, Se Yoon Chung, Sam Young Yoon, Man Soo Kim, Sung Kun Chung, Min Chul Shin, Ho Sik Hwang
PURPOSE: To introduce a new method for direct observation of tear secretion from the palpebral lobes of the main lacrimal glands and Wolfring glands using fluorescein dye. METHODS: Twenty-six patients with dry eye and 26 healthy subjects were included in the study. Fluorescein was applied to the conjunctiva overlaying the palpebral lobe of the main lacrimal glands. Under cobalt blue light, we captured tear secretion from the glands in movies. We compared the number of excretory openings, the location and tear flow rate between the dry eye and healthy-subject groups...
November 23, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27874294/dacryoadenitis-and-extraocular-muscle-inflammation-associated-with-contact-lens-related-acanthamoeba-keratitis-a-case-report-and-review-of-the-literature
#7
Tomris Sengor, Erdal Yuzbasioglu, Sevda Aydın Kurna, Murat Irkec, Ahmet Altun, Kubra Kökcen, Nazli Gul Yalcin
The present report discusses a new case of dacryoadenitis with extraocular muscle inflammation associated with Acanthamoeba keratitis (AK) in a contact lens wearer. A 41-year-old male, who has worn silicone hydrogel contact lenses on an extended basis for about 10 years, attended with the complaints of vision disturbance, hyperemia, and pain in his right eye. His history revealed that 1.5 month ago, he had been diagnosed with allergic conjunctivitis and had used steroid eye drops. Biomicroscopic examination revealed eyelid edema, chemosis, and ring infiltration, radial keratoneuritis and an epithelial defect in the cornea...
November 22, 2016: Orbit
https://www.readbyqxmd.com/read/27874148/dry-eye-disease-in-patients-with-metabolic-syndrome
#8
Kubra Serefoglu Cabuk, İlkay Cakir, Ahmet Kirgiz, Kursat Atalay, Muhittin Taskapili
OBJECTIVES: To evaluate dry eye disease (DED) in patients with metabolic syndrome (MetS) and compare with healthy individuals. METHODS: The study was conducted in the Ophthalmology and Endocrinology Department of Bagcilar Education and Research Hospital, a tertiary care center in Istanbul, Turkey, between January and December 2015. In this prospective case-controlled study, dry eye disease tests were performed on 44 patients with MetS and 43 healthy controls. TearLab Osmolarity System, which is a lab-on-a-chip technology, was used to measure tear osmolarity...
December 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27852065/mitochondria-targeted-antioxidant-skq1-reduces-age-related-alterations-in-the-ultrastructure-of-the-lacrimal-gland
#9
Lora E Bakeeva, Chupalav M Eldarov, Irina M Vangely, Nataliya G Kolosova, Valeriya B Vays
Dry eye syndrome is an eye disorder affecting many people at an old age. Because dry eye syndrome is accelerated by aging, a useful approach to the prevention of this syndrome may be an intervention into the aging process. Previously, we showed that the mitochondria-targeted antioxidant SkQ1 delays manifestations of aging and inhibits the development of age-related diseases including dry eye syndrome. Nevertheless, the link between SkQ1's effects and its suppression of age-related changes in the lacrimal gland remains unclear...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27822435/isolated-ectopic-cilia-in-an-11-year-old-girl
#10
Hosny Ahmed Zein, M Tarek A Moustafa
Ectopic cilia (EC) are a very rare condition with only few cases reported in literature. Many associations were seen with ectopic cilia which include distichiasis, choristoma and aberrant lacrimal gland, hypochromic nevus, atopic eczema and others. We are reporting a case of an 11-year-old girl with isolated left upper lid ectopic cilia, which was confirmed by surgical removal and histopathological study.
2016: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/27810641/regulating-temporospatial-dynamics-of-morphogen-for-structure-formation-of-the-lacrimal-gland-by-chitosan-biomaterials
#11
Ya-Chuan Hsiao, Tsung-Lin Yang
The lacrimal gland is an important organ responsible for regulating tear synthesis and secretion. The major work of lacrimal gland (LG) is to lubricate the ocular surface and maintain the health of eyes. Functional deterioration of the lacrimal gland happens because of aging, diseases, or therapeutic complications, but without effective treatments till now. The LG originates from the epithelium of ocular surface and develops by branching morphogenesis. To regenerate functional LGs, it is required to explore the way of recapitulating and facilitating the organ to establish the intricate and ramified structure...
October 12, 2016: Biomaterials
https://www.readbyqxmd.com/read/27808478/lacrimal-gland-ductal-carcinomas-clinical-morphological-and-genetic-characterization-and-implications-for-targeted-treatment
#12
Simon Andreasen, Morten Grauslund, Steffen Heegaard
PURPOSE: Ductal carcinomas (DCs) of the lacrimal gland are very rare but aggressive malignancies. We investigated DC of the lacrimal gland for potentially clinically actionable targets in the search for new therapeutic options. METHODS: Case 1: A 77-year-old man, presented with diplopia and xerophtalmia; case 2: A 53-year-old man, presented with headache, proptosis and chemosis and case 3: A 73-year-old man, presenting with chemosis and a corneal abscess. All three cases were characterized morphologically including immunohistochemistry and genetically with fluorescence in situ hybridization (FISH) and one case with next-generation sequencing (NGS) of cancer relevant genes...
November 3, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27800198/a-case-report-of-neurosarcoidosis-presenting-as-a-lymphoma-mimic
#13
Gurcharanjeet Kaur, Lauren Cameron, Olga Syritsyna, Patricia Coyle, Agnes Kowalska
Objective. To describe a unique presentation of neurosarcoidosis. Background. Central nervous system involvement is rare in sarcoidosis. Sarcoidosis can be severe and can be mistaken for systemic lymphoma. Case Description. A 55-year-old right-handed white male with past medical history of obstructive sleep apnea, Raynaud's disease, and Hashimoto's thyroiditis was noted to have cognitive decline over a duration of few weeks and 20 lb weight loss. His neurologic exam (including cranial nerves) was normal except for five-minute recall...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27792049/tarsal-glandular-hyperplasia-in-pachydermoperiostosis-and-implications-for-ptosis-correction
#14
Marlos R L Silva, Adriano Baccega, Ana Filipa Duarte, Fernando Chahud, Antonio Augusto V Cruz
Pachydermoperiostosis is a rare genetic disease that causes major bone and skin changes. Severe ptosis is a prominent finding in this peculiar condition. We report here 2 patients with typical features of pachydermoperiostosis. Their tarsal plates were enlarged and infiltrated by sebaceous gland tissue. One patient also displayed diffuse intratarsal lacrimal gland hyperplasia. As far as we know, this is the first report of ectopic lacrimal tissue in pachydermoperiostosis. Tarsal and skin morphologic changes should be addressed during ptosis correction in these patients...
October 11, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27790959/igg4-related-syndrome-another-multiorgan-disease-in-the-interest-field-of-internal-medicine
#15
Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Tiziana Di Chiara, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo, Antonio Pinto
BACKGROUND: IgG4-related disease is a rare, clinical and pathologic disease entity of unknown etiology. Its main features are increased serum concentrations of IgG4 > 1,35 g/l, lymphocyte and IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation of IgG4-RSD is pancreatitis which is combined with the involvement of biliary ducts in 74 percent of patients. Extrapancreatic manifestations include: abdominal or mediastinal lymphadenopathy; the involvement of salivary glands and lacrimal glands, kidneys, lung, retroperitoneum...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27789276/tear-fluid-protein-changes-in-dry-eye-syndrome-associated-with-rheumatoid-arthritis-a-proteomic-approach
#16
Saijyothi Venkata Aluru, Agarwal Shweta, Srinivasan Bhaskar, Krishnan Geetha, Rajappa M Sivakumar, Tatu Utpal, Prema Padmanabhan, Narayanasamy Angayarkanni
PURPOSE: Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA) affects lacrimal and salivary glands, and therefore dry eye syndrome (DES) is more prevalent in patients with RA. This study used a proteomic approach to identify potential biomarkers in tear of DES secondary to RA (DES-RA). METHODS: Tear specimens were collected with Schirmer strips from patients with DES with RA, patients with other types of dry eye (namely, primary Sjögrens and non-Sjögrens [NSS]), and age-matched controls...
October 24, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27782913/post-therapeutic-dosimetry-of-177lu-dkfz-psma-617-in-the-treatment-of-patients-with-metastatic-castration-resistant-prostate-cancer
#17
Madhav P Yadav, Sanjana Ballal, Madhavi Tripathi, Nishikant A Damle, Ranjit K Sahoo, Amlesh Seth, Chandrasekhar Bal
OBJECTIVE: Lu-DKFZ-PSMA-617, a urea-based compound, binds to the extracellular domain of prostate-specific membrane antigen, thus providing an effective target for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Before its therapeutic use, it is necessary that the radiation dosimetry of this radiopharmaceutical be studied to determine the safe activity that can be administered in patients to prevent haematological, renal and liver toxicity. The present study thus aimed to assess the pharmacokinetics and dosimetry of Lu-DKFZ-PSMA-617 in CRPC patients...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27777501/human-postmortem-lacrimal-and-submandibular-glands-stored-in-rnalater-are-suitable-for-molecular-biochemical-and-cell-biological-studies
#18
Dillon Hawley, Hema Aluri, Helene Armaos, Gina Kim, Claire Kublin, Driss Zoukhri
PURPOSE: Gene expression and protein analysis studies require high-quality human tissue which is a challenge and difficult to obtain through live human biopsies. Human postmortem lacrimal gland (LG) and submandibular gland (SMG) tissues have the potential to provide an invaluable source for studying the mechanisms involved in LG and SMG dysfunction. Therefore, we aimed to test the suitability of post-mortem LG and SMG for molecular, biochemical, and cell biological studies. METHODS: LG and SMG tissue from healthy donors was collected and immediately placed in RNAlater solution and then shipped overnight at 4 °C...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27777121/efficacy-of-a-new-topical-cationic-emulsion-of-cyclosporine-a-on-dry%C3%A2-eye-clinical-signs-in-an-experimental-mouse-model-of-dry-eye
#19
Philippe Daull, Laurence Feraille, Stefano Barabino, Nicolas Cimbolini, Sophie Antonelli, Virgine Mauro, Jean-Sébastien Garrigue
Dry eye disease (DED) is a complex, multifactorial pathology characterized by corneal epithelium lesions and inflammation. The aim of the present study was to evaluate the efficacy of a cationic emulsion of cyclosporine A (CsA) in a mouse model that mimics severe dry eye. Eight to 12-week-old female C57BL/6N mice with tail patches of scopolamine were housed in controlled environment chambers to induce dry eye. At day three, following dry eye confirmation by corneal fluorescein staining (CFS, score 0-15) and phenol red thread (PRT) lacrimation test, the mice (n = 10/gp) were either treated 3 times a day in both eyes with drug-free cationic emulsion, a 0...
October 21, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27754718/investigational-drugs-in-dry-eye-disease
#20
Marcella Nebbioso, Valeria Fameli, Magda Gharbiya, Marta Sacchetti, Anna Maria Zicari, Alessandro Lambiase
The dry eye disease (DED) is a chronic multifactorial disorder of the tears that also involves the ocular surface, the lacrimal glands, and meibomian dysfunction. Furthermore, DED is often associated with Sjögren's syndrome (SS) and other autoimmune disorders. Sometimes, this chronic or subclinical condition is difficult to diagnose and treat, due to its heterogeneity. Areas covered: A literature search of relevant publications about treatment of DED was performed. All relevant articles published between 2011 and 2016 were identified through a computerized search for reviews and clinical trials using the Pub Med database...
October 28, 2016: Expert Opinion on Investigational Drugs
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