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https://www.readbyqxmd.com/read/29787840/cutaneous-features-and-diagnosis-of-primary-sjogren-s-syndrome-an-update-and-review
#1
REVIEW
Preeti Jhorar, Kristin Torre, Jun Lu
Sjogren's syndrome (SS) is an autoimmune connective tissue disorder (CTD) which principally affects the lacrimal and salivary glands. Although SS is one of the three most common autoimmune CTDs alongside systemic lupus erythematosus (SLE) and progressive systemic sclerosis, it is the least researched CTD overall. SS poses a particular diagnostic challenge because it shares multiple clinical and immunologic features with other CTDs. However, there are some characteristic cutaneous clinical features that can precede the well-known sicca symptoms by years...
May 19, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29787423/autoimmune-granulomatous-inflammation-of-lacrimal-glands-and-axonal-neuritis-following-treatment-with-ipilimumab-and-radiation-therapy
#2
Ecaterina Ileana Dumbrava, Veronica Smith, Rasha Alfattal, Adel K El-Naggar, Marta Penas-Prado, Apostolia M Tsimberidou
Immune checkpoint inhibitors such as anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti PD-1 (programmed cell death protein 1) and PD-L1 (programmed cell death protein-ligand 1) monoclonal antibodies are emerging as standard oncology treatments in various tumor types. The indications will expand as immunotherapies are being investigated in various tumors with promising results. Currently, there is inadequate identification of predictive biomarkers of response or toxicity. Unique response patterns include pseudoprogression and delayed response...
May 21, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29780914/rescue-technique-for-complete-removal-of-an-accidentally-ruptured-orbital-dumbbell-deep-dermoid-cyst-a-case-report
#3
Pei-Hsuan Lin, Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Yasuhiro Takahashi, Hirohiko Kakizaki
Purpose: To report a rescue technique for complete removal of an accidentally ruptured orbital dumbbell deep dermoid cyst. Observations: A 33-year-old female presented with left proptosis with retrobulbar discomfort for 3 months. Computed tomography images showed an orbital dumbbell deep dermoid cyst. A lateral orbitotomy was performed under general anesthesia. The cyst was ruptured during osteotomy of the lateral orbital rim. The cyst was opened vertically from the ruptured site using a Stephen's tenotomy scissors to visually confirm the internal wall of the cyst and to keep the epithelial lining intact while separating the external wall of the cyst from the bone...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29773884/pathologic-features-and-expression-of-heat-shock-protein-47-in-the-nasal-mucosa-and-lacrimal-sac-does-it-influence-the-surgical-outcome-of-endoscopic-endonasal-dacryocystorhinostomy
#4
Jinhwan Park, Joonsik Lee, Sehyun Baek
PURPOSE: To correlate the pathologic features and heat shock protein 47 (HSP47) expression in the nasal mucosa and lacrimal sac with the surgical outcomes of endoscopic endonasal dacryocystorhinostomy (EDCR). METHODS: Specimens of the nasal mucosa and lacrimal sac over the rhinostomy site were collected during the operation. Haematoxylin-eosin and immunohistochemical staining were performed to determine the pathologic features (inflammation, fibrosis, squamous metaplasia) and the expression of HSP47 in the epithelium and sub-epithelial glands of the nasal mucosa and lacrimal sac...
May 18, 2018: Eye
https://www.readbyqxmd.com/read/29760585/mir-93-5p-enhance-lacrimal-gland-adenoid-cystic-carcinoma-cell-tumorigenesis-by-targeting-brms1l
#5
Jie Hao, Xin Jin, Yan Shi, Hong Zhang
Background: Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignancies that affects lacrimal gland. MicroRNAs are known to play a crucial role as oncogenes or tumor suppressors. Specifically, miR-93 has been reported to play a crucial role in colorectal, breast, pancreatic, lung cancer and hepatocellular carcinoma. However, the role of miR-93 in LACC and the potential molecular mechanisms involved remain unknown. Therefore, we took the challenge to determine the involvement of miR-93 in the LACC by targeting BRMS1L...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29755273/orbital-progressive-transformation-of-germinal-centers-as-part-of-the-spectrum-of-igg4-related-ophthalmic-disease-clinicopathologic-features-of-three-cases
#6
M Adelita Vizcaino, Shannon S Joseph, Charles G Eberhart
Progressive transformation of germinal centers (PTGC) is a form of follicular hyperplasia recently associated with immunoglobulin G4-related disease (IgG4-RD), but the ophthalmic manifestations of this combination are poorly described. In this retrospective case series, we present three cases of IgG4-related orbital disease (IgG4-ROD) showing varying degrees of PTGC involving the orbit and lacrimal gland. Three adult women presented with ill-defined lacrimal gland enlargement. Histologic sections showed variable fibrosis and large, irregular lymphoid follicles with prominent mantle zones penetrating the germinal centers, highlighted by Bcl-2 and/or IgD immunostains...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29755265/pleomorphic-adenoma-of-the-lacrimal-gland-a-review-with-updates-on-malignant-transformation-and-molecular-genetics
#7
REVIEW
William Harrison, Patricia Pittman, Thomas Cummings
Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. There is a tendency to reoccur, especially if there is an incomplete excision, and rarely, malignant transformation to carcinoma ex pleomorphic adenoma can occur, which has a much poorer prognosis...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29740252/beneficial-effect-of-daidzin-in-dry-eye-rat-model-through-the-suppression-of-inflammation-and-oxidative-stress-in-the-cornea
#8
Fan Xiao, Hua Cui, Xiao Zhong
Present investigation evaluates the effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Briefly, electron spine resonance was used for the estimation of radical scavenging activity of daidzin and COX Fluorescent Activity Assay Kit was used for the estimation of PGS activity. Dry eye rat model was developed by removing the lacrimal gland and effect of daidzin was evaluated in dry eye rat model by estimating the fluorescein score, tear volume and expressions of heme oxigenase (HO-1), TNF α, Interlukin 6 (IL-6), matrix metallopeptidase 9 (MMP-9) and PGS-2...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29736173/inhibitory-effects-of-ipsc-mscs-and-their-extracellular-vesicles-on-the-onset-of-sialadenitis-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#9
Bo Hai, Taeko Shigemoto-Kuroda, Qingguo Zhao, Ryang Hwa Lee, Fei Liu
No effective treatment for Sjögren's syndrome (SS), a chronic autoimmune disease affecting mainly salivary and lacrimal glands, is available now. Systemic infusion of allogeneic mesenchymal stem cells (MSCs) isolated from tissues such as bone marrow (BM) alleviated SS in mouse models and a small clinical trial, but further research and application of this MSC therapy were hindered by limited expandability, significant donor variations, and safety concerns of tissue-derived MSCs. To circumvent these issues, we derived MSCs from human iPSCs using an optimized protocol that can be easily scaled up to produce a huge amount of standardized MSCs...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29731668/papilloma-and-sebaceous-gland-hyperplasia-of-the-lacrimal-caruncle-a-case-report
#10
Maria Miura-Karasawa, Hiroshi Toshida, Toshihiko Ohta, Akira Murakami
Objective: To report a case of coincidence of sebaceous gland hyperplasia and papilloma with detection of human papillomavirus-51 in the apical portion by in situ hybridization. Case presentation: A 75-year-old man noted discomfort at the inner canthus of his left eye when he blinked. A tumor of the lacrimal caruncle was identified and resected. The base of the tumor had a smooth surface and was whitish. In addition, a "navel-like structure" was seen, and the findings strongly suggested sebaceous gland hyperplasia of the lacrimal caruncle...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29720329/effect-of-dental-care-on-the-oral-health-of-sj%C3%A3-gren%C3%A2-s-syndrome-patients
#11
A Lucchese, M Portelli, M Marcolina, P F Nocini, G Caldara, D Bertossi, C Lucchese, U Tacchino, M Manuelli
Sjögren’s syndrome (SS) is a chronic, systemic autoimmune disease affecting the exocrine glands, particularly the salivary and lacrimal glands. Xerostomia is a major feature of this syndrome and greatly affects patient quality of life. The most typical clinical signs associated with hyposalivation are dysgeusia and dysosmia, dental caries, candidiasis, periodontal disease, gland inflammation, mucositis and oral ulcers. The aims are to investigate on Plaque Index (PI) and Gingival Index (GI) before and after dental care of SS patients...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29705554/glycoprotein-340-in-mucosal-immunity-and-ocular-surface
#12
REVIEW
Kwaku A Osei, Champion Deivanayagam, Jason J Nichols
Glycoprotein 340 (Gp340) is an innate immune receptor with well-defined roles in mucosal tissues. It is a normal component of mucosal fluids such as tears, breast milk, and saliva, and it is expressed in tissues such as the vagina, gastrointestinal tract, oral cavity, lung alveoli, and pancreas. In the eye, it is expressed in the lacrimal gland, cornea, conjunctiva, and retina. Investigations of the protein in wet-surfaced epithelia of the body show that the effects of Gp340 can be beneficial or harmful depending on the conformation in which it exists...
April 26, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29702077/phosphosulindac-is-efficacious-in-an-improved-concanavalin-a-based-rabbit-model-of-chronic-dry-eye-disease
#13
Robert A Honkanen, Liqun Huang, Gang Xie, Basil Rigas
Dry eye disease (DED), an inflammatory disease of the ocular surface, affects 15% of humans worldwide. No satisfactory treatment exists for DED partly because of the lack of informative animal models of this disease. We evaluated the anti-inflammatory phosphosulindac (PS) for the treatment of DED using a new rabbit model of chronic DED. In this model, based on the concanavalin A (Con A) acute DED model, we injected all lacrimal glands with Con A 3 times weekly under ultrasound guidance, which prolonged DED to >3 weeks, and used concurrently 4 parameters of efficacy: tear break-up time (TBUT), tear osmolarity, Schirmer test, and tear lactoferrin levels, making efficacy assessment robust...
April 10, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29694658/bilateral-hypertrophy-of-the-lacrimal-gland-revealing-systemic-sarcoidosis
#14
Ines Kechaou, Lamia Ben Hassine, Eya Cherif, Imen Boukhris
No abstract text is available yet for this article.
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29687903/na-k-2cl-cotransporter-nkcc-physiological-function-in-nonpolarized-cells-and-transporting-epithelia
#15
Eric Delpire, Kenneth B Gagnon
Two genes encode the Na+ -K+ -2Cl- cotransporters, NKCC1 and NKCC2, that mediate the tightly coupled movement of 1Na+ , 1K+ , and 2Cl- across the plasma membrane of cells. Na+ -K+ -2Cl- cotransport is driven by the chemical gradient of the three ionic species across the membrane, two of them maintained by the action of the Na+ /K+ pump. In many cells, NKCC1 accumulates Cl- above its electrochemical potential equilibrium, thereby facilitating Cl- channel-mediated membrane depolarization. In smooth muscle cells, this depolarization facilitates the opening of voltage-sensitive Ca2+ channels, leading to Ca2+ influx, and cell contraction...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29685738/-idiopathic-orbital-inflammatory-syndrome-report-of-24-cases
#16
S Khochtali, M Zayani, I Ksiaa, I Ben Meriem, S Zaouali, B Jelliti, M Khairallah
BACKGROUND: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. PATIENTS AND METHODS: This is a retrospective review of the charts of 24 patients diagnosed with IOIS at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2015...
April 20, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29681465/botulinum-neurotoxin-a-injection-for-the-treatment-of-epiphora-with-patent-lacrymal-ducts
#17
B Girard, J-M Piaton, P Keller, T H Nguyen
HEADINGS: Retrospective longitudinal study to evaluate the efficacy of botulinum neurotoxin A (BoNT/A) therapy for epiphora with patent lacrimal ducts. BACKGROUND/PURPOSE: BoNT/A has been used since 2000 in axillary hyperhidrosis to reduce sweat secretion. Some isolated cases of hyperlacrimation or crocodile tear syndrome have been treated with BoNT/A on this basis. We report our experience in the treatment of tearing despite patent lacrimal ducts by BoNT/A injection into the lacrimal gland...
April 19, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29680804/lacrimal-gland-pleomorphic-adenoma-and-malignant-epithelial-tumours-clinical-and-imaging-differences
#18
Stephanie Ming Young, Yoon-Duck Kim, Hyun Jin Shin, Yukihiro Imagawa, Stephanie S Lang, Kyung In Woo
AIMS: To investigate the clinical and imaging features of primary and recurrent lacrimal gland pleomorphic adenoma (LGPA), as well as lacrimal gland malignant epithelial tumours (LGMET). METHODS: Retrospective comparative case series from September 2000 to September 2016 in a single tertiary institution. Medical records of cases with histopathologically proven primary LGPA (PLGPA), recurrent LGPA (RLGPA) and LGMET were reviewed. RESULTS: Sixty-four patients with LGPA (55 primary and nine recurrent) and 36 patients with LGMET underwent surgical excision in the study period...
April 21, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676321/bilateral-herpes-simplex-keratitis-reactivation-after-lacrimal-gland-botulinum-toxin-injection
#19
Purvasha Narang, Swati Singh, Vikas Mittal
Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2.5 units of BTA injection in each lacrimal gland for functional epiphora. The patient had a history of herpes simplex viral keratitis that was quiescent for more than 2 years. After 3 weeks, she developed reactivation of viral keratitis bilaterally, which was successfully managed with antivirals and topical steroids...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675349/primary-ductal-adenocarcinoma-of-lacrimal-gland-two-case-reports-and-review-of-the-literature
#20
Hsin-Yu Yang, Cheng-Hsien Wu, Chieh-Chih Tsai, Wei-Kuang Yu, Shu-Ching Kao, Catherine Jui-Ling Liu
A 64-year-old male presented with progressive proptosis of the left eye for 3 months. Orbital computed tomography (CT) demonstrated a 3.9 cm infiltrative mass over the superotemporal quadrant of the left orbit. Pathology of biopsy revealed a ductal adenocarcinoma of lacrimal gland with positive immunohistochemical staining for androgen receptor (AR), cytokeratin-7 (CK7), and gross cystic disease fluid protein 15 (GCDFP-15). The patient received orbital exenteration and adjuvant chemoradiotherapy. No recurrence or metastasis was noted 27 months after treatment...
January 2018: Taiwan Journal of Ophthalmology
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