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Lacrimal duct

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https://www.readbyqxmd.com/read/29336290/comparison-between-endoscopic-and-external-dacryocystorhinostomy-by-using-the-lacrimal-symptom-questionnaire-a-pilot-study
#1
Wai Keat Wong, Simon Dean, Salil Nair
BACKGROUND: Epiphora has a significant impact on the patient's quality of life and is commonly caused by nasolacrimal duct obstruction. Dacryocystorhinostomy (DCR) has traditionally been performed via an external approach, which involves a skin incision. With the advent of endoscopes, the endonasal approach to DCR has gained significant popularity. METHOD: To prospectively compare the quality of life of adult patients who underwent either an endonasal or an external DCR for acquired nasolacrimal duct obstruction, the Lacrimal Symptom Questionnaire (Lac-Q) was administered before and after surgery...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29305607/novel-insight-into-the-role-of-cftr-in-lacrimal-gland-duct-function-in-mice
#2
Orsolya Berczeli, Eszter Vizvári, Máté Katona, Dénes Török, László Szalay, Ferenc Rárosi, István Németh, Zoltán Rakonczay, Péter Hegyi, Chuanqing Ding, Edit Tóth-Molnár
Purpose: The role of cystic fibrosis transmembrane conductance regulator (CFTR) in lacrimal gland (LG) function has only recently received some attention, mainly from our group. In the present study, we investigated the potential changes of LG pathology, tear secretion, ocular surface integrity, and fluid secretion in isolated LG ducts from CFTR knockout (KO) mice. Methods: Tear production and ocular surface integrity were investigated in anesthetized wild-type (WT) and KO mice using cotton threads and fluorescein staining, respectively...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29302763/reduced-myofilament-component-in-primary-sj%C3%A3-gren-s-syndrome-salivary-gland-myoepithelial-cells
#3
Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Roberto Tamma, Beatrice Nico, Domenico Ribatti, Simona Ruggieri, Sabrina Lisi
Primary Sjögren's syndrome (pSS) is a solitary poorly understood autoimmune inflammatory disease by involvement of the salivary and lacrimal glands resulting in dry mouth and dry eyes. Myoepithelial cells (MECs) are cells knowing for its hybrid epithelial and mesenchymal phenotype that are important components of the salivary gland (SGs) structure aiding the expulsion of saliva from acinar lobules. In this study we investigate possible alteration in the myofilament component of MECs in SGs specimens obtained from pSS patients in comparison with healthy subjects, to evaluate MECs hypothetical involvement in the pathogenesis of pSS...
January 4, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29279839/limited-approach-in-endoscopic-dacryocystorhinostomy-of-pediatrics
#4
Seyyed Mostafa Hashemi, Afrooz Eshaghian
Background: Limited spatial nasal cavity in children, make pediatric dacryocystorhinostomy (DCR) a difficult surgical procedure. We apply a limited approach to pediatric DCR and follow them for their consequences. Materials and Methods: An experimental study was done in pediatric DCR with limited approach (age < 14-year-old). After written consent, with general anesthesia, with nasal endoscopic surgery, lacrimal bone is exposed and extruded. In contrast with routine procedure, ascending process of maxillary sinus reserve; and marsupialization and wide exposure to lacrimal sac was done only by lacrimal bone defect; and cannulation preserve with temporary silicone tube...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29238676/double-posterior-based-flap-technique-in-primary-endoscopic-dacryocystorhinostomy-with-and-without-using-powered-instrument
#5
Pradeep Pradhan, Abhishek Bhardwaj, Santanu Mandal, Sudhir Majhi
To demonstrate the surgical technique and outcomes of double posterior based flap technique in primary endoscopic dacryocystorhinostomy (DCR) with and without use of powered instrument. 28 patients of nasolacrimal duct obstruction were included in the study from September 2012 to February 2015. All underwent endoscopic dacryocystorhinostomy with double posterior based nasal and lacrimal flap technique. In patients of group A (14 patients), bone removal was done with the help of Smith-Kerrison punch forceps and in patients of group B (14 patients), powered drill has been used for the same...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29222730/morphology-and-morphometry-of-lacrimal-drainage-system-in-relation-to-bony-landmarks-in-caucasian-adults-a-cadaveric-study
#6
Mohammad Javed Ali, Martin Schicht, Friedrich Paulsen
PURPOSE: The objective of this study is to examine the morphometry of the lacrimal drainage system with reference to bony landmarks in the vicinity. METHODS: Twenty midsaggitalized heads obtained from sixteen preserved cadavers were studied. Measurements involved detailed morphometry of anterior and posterior lacrimal crests, bony lacrimal sac fossa, entrance and length of the bony nasolacrimal duct (NLD), attachment of Horner's muscle, and characteristics of the inferior meatal opening of the NLD...
December 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29217030/perforated-punctal-plugs-with-adjuvant-use-of-mitomycin-c-in-management-of-acquired-external-punctal-stenosis-grades-0-and-1
#7
Ayman S Abd El Ghafar, Amr M El-Kannishy, Mohamed M Elwan, Dalia Sabry, Hanem M Kishk, Eman M Elhefney
OBJECTIVE: To evaluate the use of perforated punctal plugs with adjuvant application of mitomycin-C in the management of acquired external punctal stenosis grades 0 and 1. METHODS: This is a prospective interventional case series including 30 eyes of 30 patients with acquired external punctal stenosis of the lower punctum of grades 0 and 1 presenting with epiphora. They were examined to exclude other causes of lacrimation and epiphora: Slit-lamp assessment of the stenosed punctum and grading was done, probing was done to exclude associated canalicular stenosis, and syringing was done to exclude nasolacrimal duct obstruction...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29194257/clinical-significance-of-biofilm-on-silicone-tubes-removed-from-patients-with-nasolacrimal-duct-stenosis
#8
Sung Hyun Kim, Choul Yong Park, Sang Won Hwang, Minwook Chang
PURPOSE: To determine the relationship between the optical density of biofilms on silicone tubes and surgical outcomes. METHODS: A total of 43 silicone tubes from 33 patients with nasolacrimal duct stenosis were enrolled at 6 months after bicanalicular silicone tube intubation. The removed silicone tubes were divided into 2 segments. One segment of silicone tube was cultured while the other segment was used to measure optical density of biofilm. Each segment was divided into 3 pieces according to average normal human nasolacrimal anatomy...
November 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29184387/lacrimal-drainage-anomalies-in-congenital-rubella-syndrome
#9
Shweta Gupta, Mohammad Javed Ali, Milind N Naik
Purpose: The objective of this study was to ascertain the lacrimal drainage anomalies in a cohort of patients suffering from congenital rubella syndrome (CRS). Methods: This was a retrospective case series performed in patients with CRS presenting with associated lacrimal drainage anomalies (LDA) over 6 years from 2011 to 2016. All the patients were confirmed as having CRS after clinical and laboratory testing. Data collected include demographics; associated lacrimal, ocular, and systemic anomalies; interventions performed for lacrimal anomalies; and their anatomical and functional outcomes...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29183042/expression-and-regulation-of-s100-fused-type-protein-hornerin-at-the-ocular-surface-and-lacrimal-apparatus
#10
Fabian Garreis, Janine Jahn, Katharina Wild, Daniel B Abrar, Martin Schicht, Jens-Michael Schröder, Friedrich Paulsen
Purpose: The S100 fused-type proteins hornerin (HRNR) and filaggrin-2 (FLG2) are members of the epidermal differentiation complex, which is involved in terminal differentiation of keratinocytes via cornification as well as maintenance of the epidermal antimicrobial barrier. We investigated the expression and possible regulation of HRNR and FLG2 at the ocular surface and in the lacrimal apparatus. Methods: Tissues of the lacrimal apparatus and ocular surface were analyzed systematically by means of RT-PCR, immunohistochemistry, and immuntransmission electron microscopy (iTEM) for their ability to express and produce HRNR and FLG2...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29165408/-mitomycin-c-after-endoscopic-endonasal-dacryocystorhinostomy
#11
E L At'kova, G V Ramenskaya, A O Root, N N Krakhovetskiy, V D Yartsev, S D Yartsev, A E Petukhov, I E Shokhin
Mitomycin-C (MMC) is the most frequently used agent for prevention of excessive scarring at the osteotomy site after endoscopic endonasal dacryocystorhinostomy (EEDCR), which, however, being applied during the final stage of the surgery, shows questionable effectiveness. AIM: to evaluate the effectiveness of a new administration route of mitomycin C in EEDCR. MATERIAL AND METHODS: The study included 86 patients (95 cases) in the age range of 62.3±9 years with primary acquired nasolacrimal duct obstruction...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29142801/idiopathic-acquired-dacryocystocele-presenting-only-with-epiphora-a-very-rare-case-report
#12
Muhammad Jahanzaib Anwar, Saad A Choudhry, Muhammad Aadil, Ahmer Asif, Atif Ameer
A 42-years-old male presented with left medial canthal swelling, accompanied with only mild epiphora. There was no history of dacryocystitis, mid-facial trauma, surgery, or bloody tears. On examination, there was an immobile, subcutaneous, non-inflammatory mass below the medial canthal tendon. Lacrimal irrigation showed blockade at the nasolacrimal duct. A computerized axial tomography (CAT) scan revealed a non-enhancing, low-density, cystic lesion at the inferomedial margin of the orbit. There were no signs of bony erosion, consistent with idiopathic acquired dacryocystocele...
September 4, 2017: Curēus
https://www.readbyqxmd.com/read/29121183/primary-vs-secondary-endoscopic-dacryocystorhinostomy-for-acute-dacryocystitis-with-lacrimal-sac-abscess-formation-a-randomized-clinical-trial
#13
Emmy Y Li, Emily S Wong, Alex C Wong, Hunter K Yuen
Importance: Endoscopic dacryocystorhinostomy (EN-DCR) is emerging as the preferred procedure in the management of nasolacrimal duct obstructions. However, its safety and long-term efficacy in the setting of acute dacryocystitis with lacrimal sac abscess have not been well studied. Objective: To compare outcomes of EN-DCR as primary treatment with EN-DCR as a secondary treatment after percutaneous drainage of lacrimal sac abscess in acute dacryocystitis. Design, Setting, and Participants: This randomized clinical trial was conducted from October 1, 2012, to October 31, 2015, at a tertiary ophthalmic center...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29120068/diagnosis-and-genetics-of-alacrima
#14
REVIEW
J Adams, C P Schaaf
Alacrima, the lack of tears, is a rare clinical finding that has been reported as a feature of multiple genetic disorders and can serve as a diagnostic clue to some rare conditions. Causes of alacrima range from absence/hyposecretion of tears to agenesis or improper development of lacrimal gland ducts and associated structures. There are 13 known heritable disorders featuring varying degrees and causes of alacrima. Some manifest only the congenital absence of tears, while others affect multiple organ systems and may involve severe developmental delay, intellectual disability, and potentially life-threatening autonomic dysregulation...
November 9, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29071273/chronic-lymphocytic-leukaemia-small-cell-lymphocytic-lymphoma-of-the-lacrimal-sac-a-case-series
#15
Yamini Krishna, Luciane D Irion, Sozan Karim, Aruna Dharmsena, Austin McCormick, Sarah E Coupland
BACKGROUND: Lymphomas of the lacrimal sac are rare, accounting for less than 10% of lacrimal sac malignant tumours. They may present with symptoms typical of secondary acquired nasolacrimal duct obstruction and are thus often misdiagnosed. METHODS: Case series and literature review. RESULTS: Herein we describe 3 cases of chronic lymphocytic leukaemia (CLL)/small-cell lymphocytic lymphoma (SLL) of the lacrimal sac with immunohistochemical and in 1 case molecular confirmation...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29053675/transcanalicular-diode-laser-assisted-dacryocystorhinostomy-for-the-treatment-of-primary-acquired-nasolacrimal-duct-obstruction
#16
Joel M Mor, Yongwei Guo, Konrad R Koch, Ludwig M Heindl
Today's gold standard in the treatment of infrasaccal primary acquired nasolacrimal duct obstruction (PANDO) is external dacryocystorhinostomy (DCR), a relatively invasive procedure that can be performed after failure of recanalizing treatments. However, with progress in the field of diode laser technology, new approaches have emerged. Laser-assisted transcanalicular DCR with subsequent bicanalicular silicon intubation is a new option showing great promise as a viable minimally invasive procedure. Under permanent endoscopic visual control from the nasal cavity, a diode laser fiber is inserted into the lacrimal sac and laser energy is applied to create a bony ostium between the lacrimal sac and the nasal cavity...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29049098/distribution-of-elastic-fibers-in-the-lacrimal-sac-and-nasolacrimal-duct-of-japanese-cadavers
#17
Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Takashi Nakano, Munekazu Naito, Hiroshi Ikeda, Hidetaka Miyazaki, Hirohiko Kakizaki
PURPOSE: To investigate the distribution of elastic fibers in lacrimal sac and nasolacrimal duct of Japanese cadavers. METHODS: We examined 8 lacrimal sacs and nasolacrimal ducts of 7 Japanese cadavers (4 right sides, 4 left sides; 3 mal es, 4 females; average age of 89 years at death) that were preserved with 10% buffered formalin. The harvested specimens were transversely sectioned. All specimens were stained with Elastica van Gieson. Micrographs were taken, and then converted to white and black images, and the elastic fiber density of 4 locations (middle and upper levels of lacrimal sac, and middle and lower levels of nasolacrimal duct) was compared...
October 14, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28991351/the-treatment-of-congenital-nasolacrimal-duct-obstruction-in-children-a-retrospective-review
#18
H Sprague Eustis, An H Nguyen
PURPOSE: To compare success and extrusion rates of the monocanalicular and bicanalicular Crawford intubation systems (JEDMED Instrument Company, St. Louis, MO). METHODS: A retrospective review of all children who were diagnosed as having congenital nasolacrimal duct obstruction and treated with lacrimal intubation from 2005 to 2014 was performed. The total number of eyes included was 168 (75 and 93 right and left eyes, respectively). Bicanalicular intubation was used in 80 eyes (bicanalicular group) and monocanalicular intubation was used in 88 eyes (monocanalicular group)...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28990975/endoscopic-features-of-varices-involving-lacrimal-sac-and-nasolacrimal-duct
#19
Mohammad Javed Ali, Shweta Gupta
No abstract text is available yet for this article.
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28987318/co-instillation-of-nano-solid-magnesium-hydroxide-enhances-corneal-permeability-of-dissolved-timolol
#20
Noriaki Nagai, Fumihiko Ogata, Hiroko Otake, Naohito Kawasaki, Yosuke Nakazawa, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71 nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not affect the behavior (balance of secretion and excretion) of the lacrimal fluid in rabbit corneas...
October 5, 2017: Experimental Eye Research
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