keyword
https://read.qxmd.com/read/37679679/the-risk-of-acute-kidney-injury-in-colorectal-cancer-survivors-an-english-population-based-matched-cohort-study
#21
JOURNAL ARTICLE
Kirsty Andresen, Helena Carreira, Helen Strongman, Helen I McDonald, Sara Benitez-Majano, Kathryn E Mansfield, Dorothea Nitsch, Laurie A Tomlinson, Krishnan Bhaskaran
BACKGROUND: Colorectal cancer survival has improved in recent decades but there are concerns that survivors may develop kidney problems due to adverse effects of cancer treatment or complications of the cancer itself. We quantified the risk of acute kidney injury (AKI) in colorectal cancer survivors compared to people with no prior cancer. METHODS: Retrospective matched cohort study using electronic health record primary care data from the Clinical Practice Research Datalink GOLD linked to hospital data in England (HES-APC)...
September 7, 2023: BMC Cancer
https://read.qxmd.com/read/37671773/association-between-serum-urea-concentrations-and-the-risk-of-colorectal-cancer-particularly-in-individuals-with-type-2-diabetes-a-cohort-study
#22
JOURNAL ARTICLE
Peipei Gao, Zhendong Mei, Zhenqiu Liu, Dongliang Zhu, Huangbo Yuan, Renjia Zhao, Kelin Xu, Tiejun Zhang, Yanfeng Jiang, Chen Suo, Xingdong Chen
Dysregulation of the urea cycle (UC) has been detected in colorectal cancer (CRC). However, the impact of the UC's end product, urea, on CRC development remains unclear. We investigated the association between serum urea and CRC risk based on the data of 348 872 participants cancer-free at recruitment from the UK Biobank. Multivariable Cox proportional hazards models were fitted to conduct risk estimates. Stratification analyses based on sex, diet pattern, metabolic factors (including body mass index [BMI], the estimated glomerular filtration rate [eGFR] and type 2 diabetes [T2D]) and genetic profiles (the polygenic risk score [PRS] of CRC) were conducted to find potential modifiers...
September 6, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37645627/association-between-sulfur-microbial-diet-and-the-risk-of-colorectal-cancer-precursors-in-older-adults
#23
JOURNAL ARTICLE
Yi Xiao, Hongmei He, Ling Xiang, Haitao Gu, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Bo Li, Qi Wei, Zhiyong Zhu, He Zhou, Yunhao Tang, Zhihang Zhou, Linglong Peng, Yaxu Wang, Yahui Jiang
BACKGROUND: Sulfur microbial diet (SMD), related to the enrichment of sulfur-metabolizing gut bacteria, has been confirmed to be linked to an elevated risk of early-onset colorectal adenoma in young females. However, it remains unclear whether SMD is associated with the risk of colorectal adenoma in older people, who are at greater risk for colorectal cancer. METHODS: All data on participants in this study were retrieved from the intervention arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening test...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37588311/protective-effects-of-long-term-usage-of-cyclo-oxygenase-2-inhibitors-on-colorectal-cancer-in-genetically-predisposed-individuals-and-their-overall-effect-on-prognosis-a-systematic-review
#24
REVIEW
Sri Harsha Narayana, Ujala Mushtaq, Basim Shaman Ameen, Chuhao Nie, Daniel Nechi, Iqra J Mazhar, Mohamed Yasir, Saba Sarfraz, Gandhala Shlaghya, Safeera Khan
Colorectal cancer (CRC) is a major global health concern, accounting for significant cancer-related morbidity and mortality worldwide. Despite advancements in early detection and treatment modalities, the prevention of CRC remains a critical goal. Cyclo-oxygenase-2 (COX-2) is an inducible enzyme involved in the production of pro-inflammatory prostaglandins, which play a crucial role in various cellular processes, including inflammation, cell proliferation, apoptosis, and angiogenesis. Elevated COX-2 expression has been consistently observed in colorectal tumors, indicating their role in the pathogenesis of cancer...
July 2023: Curēus
https://read.qxmd.com/read/37580670/selective-cox-2-inhibitors-do-not-increase-gastrointestinal-reactions-after-colorectal-cancer-surgery-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Ting Hu, Cheng-Jiang Liu, Xiaoming Yin, WenJuan Tang, LanFang Yin, Hui Bai, FangFang Liu, Dan Wang, YiLei Li
BACKGROUND: The effectiveness of selective COX-2 inhibitors in preventing colorectal cancer recurrence has been demonstrated, however it is unknown how safe and successful they will be over the long term. As a result, we looked at the efficacy, safety, and consequences of adding COX-2 inhibitors to the treatment plan afterward. METHODS: In patients with advanced colorectal cancer, we compared the efficacy of celecoxib at two different doses (200 mg twice day and 400 mg twice daily) with placebo...
August 14, 2023: BMC Gastroenterology
https://read.qxmd.com/read/37573705/clinical-score-for-colorectal-cancer-patients-with-lung-limited-metastases-undergoing-surgical-resection-meta-lung-score
#26
JOURNAL ARTICLE
Pina Ziranu, Paolo Albino Ferrari, Francesco Guerrera, Pietro Bertoglio, Alessandro Tamburrini, Andrea Pretta, Paraskevas Lyberis, Giulia Grimaldi, Eleonora Lai, Massimiliano Santoru, Fabio Bardanzellu, Laura Riva, Francesca Balconi, Eleonora Della Beffa, Marco Dubois, Matteo Pinna-Susnik, Clelia Donisi, Enrico Capozzi, Valeria Pusceddu, Alessandro Murenu, Marco Puzzoni, Federico Mathieu, Sabrina Sarais, Aiman Alzetani, Luca Luzzi, Piergiorgio Solli, Piero Paladini, Enrico Ruffini, Roberto Cherchi, Mario Scartozzi
BACKGROUND: Radical resection of isolated lung metastases (LM) from colorectal cancer (CRC) is debated. Like Fong's criteria in liver metastases, our study was meant to assign a clinical prognostic score in patients with LM from CRC, aiming for better surgery selection. METHODS: We retrospectively analyzed data from 260 CRC patients who underwent curative LM resection from December 2002 to January 2022, verifying the impact of different clinicopathological features on the overall survival (OS)...
August 9, 2023: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/37559947/dual-blockade-of-ep2-and-ep4-signaling-is-required-for-optimal-immune-activation-and-antitumor-activity-against-prostaglandin-expressing-tumors
#27
JOURNAL ARTICLE
Brian J Francica, Anja Holtz, Justine Lopez, David Freund, Austin Chen, Dingzhi Wang, David Powell, Franciele Kipper, Dipak Panigrahy, Raymond N Dubois, Chan C Whiting, Peppi Prasit, Thomas W Dubensky
UNLABELLED: While the role of prostaglandin E2 (PGE2) in promoting malignant progression is well established, how to optimally block the activity of PGE2 signaling remains to be demonstrated. Clinical trials with prostaglandin pathway targeted agents have shown activity but without sufficient significance or dose-limiting toxicities that have prevented approval. PGE2 signals through four receptors (EP1-4) to modulate tumor progression. EP2 and EP4 signaling exacerbates tumor pathology and is immunosuppressive through potentiating cAMP production...
August 2023: Cancer Res Commun
https://read.qxmd.com/read/37536716/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-and-korean-cancer-prevention-guidelines-and-cancer-risk-a-prospective-cohort-study-from-the-health-examinees-gem-study
#28
JOURNAL ARTICLE
Jeeyoo Lee, Aesun Shin, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee
OBJECTIVES: The purpose of this study was to explore the association between adherence to 2 cancer prevention recommendations and cancer risk. METHODS: In total, 104,386 individuals aged 40-69 years old who were recruited between 2004 and 2013 in the Health Examinees-Gem study were included. Adherence scores were constructed based on 8 items from the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations, including body weight, physical activity, diet, alcohol consumption and breastfeeding, and on 6 items from the Korean cancer prevention guidelines (smoking status, eating vegetables and fruits, salty foods, alcohol intake, physical activity, and body weight)...
August 1, 2023: Epidemiology and Health
https://read.qxmd.com/read/37528844/colorectal-cancer-risk-after-removal-of-polyps-in-fecal-immunochemical-test-based-screening
#29
JOURNAL ARTICLE
D E F W M van Toledo, J E G IJspeert, M C W Spaander, I D Nagtegaal, M E van Leerdam, I Lansdorp-Vogelaar, E Dekker
BACKGROUND: Colonoscopy surveillance intervals are based on the predicted risk of metachronous colorectal cancer (CRC) after polyp removal. However, risk estimation per polyp subtype is difficult due to the fact that many patients have multiple polyps. To enable risk estimation per polyp subtypes we examined the metachronous CRC risk of subgroups based on presence or absence of co-occurring findings. METHODS: Using high-quality screening colonoscopies performed after a positive fecal immunochemical test between 2014 and 2020 within the Dutch CRC screening program, we applied Cox regression analysis to evaluate the association between findings at baseline colonoscopy and metachronous CRCs...
July 2023: EClinicalMedicine
https://read.qxmd.com/read/37513827/medicinal-characteristics-of-withania-somnifera-l-in-colorectal-cancer-management
#30
REVIEW
John M Macharia, Zsolt Káposztás, Raposa L Bence
Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight into the physiological regulatory mechanisms employed by rapidly proliferating cancer cells. Due to the severe side effects of cancer chemotherapeutic medications, plant chemicals and their analogues are now explored more frequently for the treatment and prevention of colorectal cancer (CRC), opening the stage for new phytotherapeutic strategies that are considered effective and safe substitutes...
June 22, 2023: Pharmaceuticals
https://read.qxmd.com/read/37500168/outcomes-for-colorectal-cancer-cases-with-peritoneal-metastases-treated-with-cytoreductive-surgery-with-or-without-hyperthermic-intraperitoneal-chemotherapy-a-comparative-analysis-of-survival-between-peritoneal-carcinomatosis-scores-pci-in-a-single-centre
#31
JOURNAL ARTICLE
Shoma Barat, Ruwanthi Wijayawardana, David Morris
BACKGROUND/AIM: Peritoneal cancer index (PCI) has been a strong indicator of prognosis for patients receiving cytoreductive surgery. The aim of this single institution study was to compare the survival of peritoneal carcinoma cases treated with cytoreduction surgery arising from colorectal cancer grouped by PCI scores. PATIENTS AND METHODS: A retrospective study of a prospective dataset maintained from 2000 till September 2022, for peritoneal metastases from colorectal cancers was carried out...
August 2023: Anticancer Research
https://read.qxmd.com/read/37481200/targeting-beta-catenin-signaling-for-prevention-of-colorectal-cancer-nutraceutical-drug-and-dietary-options
#32
REVIEW
Simon Bernard Iloki Assanga, Lidianys María Lewis Luján, Mark F McCarty
Progressive up-regulation of β-catenin signaling is very common in the transformation of colorectal epithelium to colorectal cancer (CRC). Practical measures for opposing such signaling hence have potential for preventing or slowing such transformation. cAMP/PKA activity in colon epithelium, as stimulated by COX-2-generated prostaglandins and β2-adrenergic signaling, boosts β-catenin activity, whereas cGMP/PKG signaling has the opposite effect. Bacterial generation of short-chain fatty acids (as supported by unrefined high-carbohydrate diets, berberine, and probiotics), dietary calcium, daily aspirin, antioxidants opposing cox-2 induction, and nicotine avoidance, can suppress cAMP production in colonic epithelium, whereas cGMP can be boosted via linaclotides, PDE5 inhibitors such as sildenafil or icariin, and likely high-dose biotin...
October 5, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37429364/serum-25-hydroxyvitamin-d-levels-and-risk-of-colorectal-cancer-an-age-stratified-analysis
#33
JOURNAL ARTICLE
Yejin Kim, Yoosoo Chang, Yoosun Cho, Jiwon Chang, Kyungeun Kim, Dong-Il Park, Soo-Kyung Park, Hee-Kyung Joh, Mi Kyung Kim, Chanmin Kim, Sarah H Wild, Christopher D Byrne, Seungho Ryu
BACKGROUND & AIMS: The role of circulating 25-hydroxyvitamin D (25(OH)D) in the prevention of early-onset colorectal cancer (CRC) in young adults aged <50 years is uncertain. We evaluated the age-stratified associations (<50 vs ≥50 years) between circulating 25(OH)D levels and the risk of CRC in a large sample of Korean adults. METHODS: Our cohort study included 236,382 participants (mean age, 38.0 [standard deviation, 9.0] years) who underwent a comprehensive health examination, including measurement of serum 25(OH)D levels...
July 8, 2023: Gastroenterology
https://read.qxmd.com/read/37346909/dietary-glycemic-index-glycemic-load-and-renal-cancer-risk-findings-from-prostate-lung-colorectal-and-ovarian-cancer-trial
#34
JOURNAL ARTICLE
Honggang Qi, Dan Xia, Xin Xu
BACKGROUND: Dietary glycemic index (GI) or glycemic load (GL) has been associated with the development of many cancers, but the evidence for renal cancer is still limited. The aim of the present study was to investigate the association between GI or GL and renal cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. METHODS: The cohort for our analysis consisted of 101,190 participants. GI and GL were calculated from the FFQ data using previously published reference values...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37336961/serum-25-hydroxyvitamin-d-concentrations-and-colorectal-cancer-incidence-in-adults-with-type-2-diabetes
#35
JOURNAL ARTICLE
Jiao-Jiao Ren, Zhi-Hao Li, Wen-Fang Zhong, Pei-Liang Chen, Qing-Mei Huang, Xiao-Meng Wang, Ping-Ming Gao, Chen Mao
BACKGROUND: To examine the association of serum 25-hydroxyvitamin D (25[OH]D) with colorectal cancer (CRC) risk in adults with type 2 diabetes (T2D). METHODS: Using UK Biobank data, this study included 18,453 adults with T2D. Serum 25(OH)D concentrations were determined by the chemiluminescent immunoassay method. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC outcomes. RESULTS: During a median follow-up of 8...
June 19, 2023: British Journal of Cancer
https://read.qxmd.com/read/37302674/low-dose-acetylsalicylic-acid-for-cancer-prevention-considering-risk-factors-a-retrospective-cohort-study
#36
JOURNAL ARTICLE
Dídac Florensa, Jordi Mateo, Francesc Solsona, Leonardo Galván, Miquel Mesas, Ramon Piñol, Leonardo Espinosa-Leal, Pere Godoy
BACKGROUND: Aspirin (acetylsalicylic acid) has been reported to protect against certain cancers. However, patient-related risk factors may moderate protective effects, including excess weight, smoking, risky alcohol use, and diabetes. We explore the cancer-risk relationship between aspirin intake and those four factors. METHODS: Retrospective cohort study of cancers, aspirin intake, and four risk factors in persons aged ≥50 years. Participants received medication 2007-2016, and cancers were diagnosed 2012-2016...
June 9, 2023: Annals of Epidemiology
https://read.qxmd.com/read/37294347/the-association-between-sociodemographic-clinical-and-potentially-preventive-therapies-with-oxaliplatin-induced-peripheral-neuropathy-in-colorectal-cancer-patients
#37
JOURNAL ARTICLE
Robert B Hines, Christopher Schoborg, Timothy Sumner, Xiang Zhu, Elizabeth A Elgin, Shunpu Zhang
PURPOSE: The purpose of this retrospective cohort study was to evaluate whether several potentially preventive therapies reduced the rate of oxaliplatin-induced peripheral neuropathy (OIPN) in colorectal cancer patients and to assess the relationship of sociodemographic/clinical factors with OIPN diagnosis. METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results database combined with Medicare claims. Eligible patients were diagnosed with colorectal cancer between 2007 and 2015, ≥ 66 years of age, and treated with oxaliplatin...
June 9, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37280092/cyclooxygenase-inhibitors-and-cancer-the-missing-pieces
#38
JOURNAL ARTICLE
Carlo Patrono
At 125, aspirin still represents the cornerstone of anti-platelet therapy for the acute treatment and long-term prevention of atherothrombosis. The development of a selective regimen of low-dose aspirin for the inhibition of platelet thromboxane production was key to maximizing its antithrombotic efficacy and minimizing its gastrointestinal toxicity. Based on about 50 observational studies, published over the past 30 years, aspirin and other cyclooxygenase inhibitors have been associated with a reduced risk of colorectal cancer, and possibly other digestive tract cancers...
June 6, 2023: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/37261538/impact-of-ileostomy-in-the-adjuvant-treatment-and-outcome-of-colon-cancer
#39
JOURNAL ARTICLE
Germán Calderillo-Ruíz, Horacio Noé López-Basave, Wendy Rossemary Muñoz-Montaño, María Consuelo Díaz-Romero, Berenice Carbajal-López, Carolina Castillo-Morales, Eloy Andrés Pérez-Yépez, Alejandra Albarran-García
BACKGROUND: After tumor resection, a preventive diverting loop ileostomy creation is a routine surgical procedure to prevent anastomotic leakage and infections and to preclude secondary surgeries. Despite its benefits, several studies have proposed potential complications that extend the disease course by impairing the feasibility of adjuvant chemotherapy and adherence. PURPOSE: The aim of this study was to evaluate the impact of ileostomy complications on the adherence to adjuvant treatment and overall survival (OS) of colon cancer (CC) patients...
June 1, 2023: International Journal of Colorectal Disease
https://read.qxmd.com/read/37255940/association-between-dietary-approaches-to-stop-hypertension-eating-pattern-and-lung-cancer-risk-in-98-459-participants-results-from-a-large-prospective-study
#40
JOURNAL ARTICLE
Zhiyong Zhu, Linglong Peng, Haitao Gu, Yunhao Tang, Yi Xiao, Hongmei He, Mingying Yang, Ling Xiang, Yaxu Wang
BACKGROUND: Dietary approaches to stop hypertension (DASH) eating pattern is linked to anti-inflammatory responses and antioxidation, which overlap with the pathogenesis of lung cancer. However, there is insufficient epidemiological evidence to link this dietary pattern to lung cancer risk conclusively. AIM: To determine if adherence to the DASH diet is linked to a lower risk of developing lung cancer in a large prospective study. METHODOLOGY: The data of participants were retrieved from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial...
2023: Frontiers in Nutrition
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