Purnima Singh, Liting Zhou, Disheet A Shah, Romina B Cejas, David K Crossman, Mariam Jouni, Tarek Magdy, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Donald E McKenna, Steve Horvath, Saro H Armenian, Frank M Balis, Douglas S Hawkins, Frank G Keller, Melissa M Hudson, Joseph P Neglia, A Kim Ritchey, Jill P Ginsberg, Wendy Landier, Paul W Burridge, Smita Bhatia
Anthracycline-induced cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Aberrant DNA methylation plays a role in de novo cardiovascular disease. Epigenetic processes could play a role in anthracycline-induced cardiomyopathy but remain unstudied. We sought to examine if genome-wide differential methylation at 'CpG' sites in peripheral blood DNA is associated with anthracycline-induced cardiomyopathy. This report used participants from a matched case-control study; 52 non-Hispanic White, anthracycline-exposed childhood cancer survivors with cardiomyopathy were matched 1:1 with 52 survivors with no cardiomyopathy...
August 4, 2023: Scientific Reports