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https://www.readbyqxmd.com/read/28648006/-0-5-gy-x-ray-radiation-promotes-osteoblast-differentiation-by-wnt-%C3%AE-catenin-signaling
#1
M Chen, Q R Dong, Q Huang, C She, W Xu
Objective: To investigate the important roles of Wnt signaling in the processes of 0.5Gy X-ray promoting osteoblast differentiation, and make clear the molecular mechanisms involved. Methods: Flow cytometry was employed to detect the apoptosis after osteoblast exposure to 0.5 Gy X-ray radiation.The protein level of osteoblast differentiation markers, such as collagen Iα (Col1α), alkaline phosphatase (ALP), osteocalcin (OCN), were detected by Western-blot and ALP activity staining was performed. Real-time PCR and Western-blot were utilized to evaluate the variations of key factors in Wnt signaling pathways, while specific inhibitor of Wnt/β-Catenin, XAV939 was used to block the Wnt signaling...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647894/keratin-gene-mutations-influence-the-keratinocyte-response-to-dna-damage-and-cytokine-induced-apoptosis
#2
Tina Zupancic, Gregor Sersa, Hans Törmä, Ellen Birgitte Lane, Harald Herrmann, Radovan Komel, Mirjana Liovic
The keratin filament cytoskeleton is vital to the normal function of epithelial cells. It provides structural support and regulates different aspects of cell metabolism. Mutations in keratins 5 and 14 cause a skin fragility disorder, epidermolysis bullosa simplex (EBS). Patients with severe EBS have an increased cumulative risk for basal cell carcinoma. In this study, we tested how keratin 5 and 14 mutant EBS patient-derived keratinocytes behave in the face of two different types of stressors that are able to induce cell death: ionizing radiation and cytokines TNF-α and TRAIL...
June 24, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28647834/influence-of-multi-leaf-collimator-leaf-transmission-on-head-and-neck-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-planning
#3
Motoharu Sasaki, Masahide Tominaga, Takeshi Kamomae, Hitoshi Ikushima, Motonori Kitaoka, Ryota Bando, Kanako Sakuragawa, Masataka Oita
The aim of this study was to quantify the effect of multi-leaf collimators (MLCs) with different leaf widths on the planning of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Toward this objective, dose transmission through a high-definition 120-leaf MLC (HD120MLC) and 120-leaf Millennium MLC (M120MLC) was investigated, using it with a test case and clinical case studies. In test case, studies with IMRT and VMAT plans, the difference in MLC leaf width had a limited effect on planning target volumes (PTVs)...
June 24, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28647777/the-effect-of-low-and-high-power-microwave-irradiation-on-in-vitro-grown-sequoia-plants-and-their-recovery-after-cryostorage
#4
A Halmagyi, E Surducan, V Surducan
Two distinct microwave power levels and techniques have been studied in two cases: low-power microwave (LPM) irradiation on in vitro Sequoia plants and high-power microwave (HPM) exposure on recovery rates of cryostored (-196°C) Sequoia shoot apices. Experimental variants for LPM exposure included: (a) in vitro plants grown in regular conditions (at 24 ± 1°C during a 16-h light photoperiod with a light intensity of 39.06 μEm(-2) s(-1) photosynthetically active radiation), (b) in vitro plants grown in the anechoic chamber with controlled environment without microwave irradiation, and (c) in vitro plants grown in the anechoic chamber with LPM irradiation for various times (5, 15, 30, 40 days)...
June 24, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28647717/a-large-choledochocystolithiasis-mimicking-mirizzi-syndrome
#5
Mustafa Belal Hafeez Chaudhry, Muhammad Azeemuddin, Muhammad Rizwan Khan, Om Parkash
An 18-year-old man presented with spontaneous severe epigastric pain, progressing and radiating to back since 3 days. It was associated with epigastric tenderness, bilious vomiting and jaundice. He had been intermittently experiencing these symptoms for the last 1 year. No known comorbid. Ultrasound showed a poorly visualised heterogeneous focus at porta hepatis; considering poor visualisation, this might represent an enlarged calcified lymph node or cystic duct calculus causing extrinsic compression or a large sludge ball within the common bile duct (CBD), leading to dilatation of common hepatic duct and intrahepatic biliary system...
June 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28647663/management-of-residual-tumor-after-limited-subtotal-resection-of-large-vestibular-schwannomas-lessons-learned-and-a-rationale-for-specialized-care
#6
William R Copeland, Matthew L Carlson, Brian A Neff, Colin L W Driscoll, Michael J Link
BACKGROUND: In an era where subtotal resection (STR) is increasingly utilized, we have encountered a growing number of patients referred to our institution with limited resection of large vestibular schwannomas (VS), at times associated with grave complications. OBJECTIVE: We highlight lessons learned in the management of large VS and provide a rationale for specialized care. METHODS: A prospectively maintained database of over 2,000 patients with VS evaluated at our institution between 2000 and 2016 was reviewed...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647630/endovascular-repair-of-iatrogenic-iliocaval-fistula-causing-high-output-cardiac-failure-after-spine-fusion
#7
Seth Noland, Carlos A Espinoza, Jonathan D Dvorak, John D Rose, C Steven Powell
The case being presented is a 35-year-old female with a three-year history of progressive dyspnea and right-sided heart failure following spine surgery. Physical examination identified a continuous bruit in the lower abdomen radiating to her back which prompted further evaluation. Echocardiography showed normal left ventricle (LV) systolic function, enlarged right ventricle (RV), functional tricuspid regurgitation (TR) and moderate pulmonary hypertension. A computed tomography (CT) scan of the abdomen and pelvis demonstrated findings consistent with an arteriovenous fistula (AVF) between the right common iliac artery and the inferior vena cava (IVC)...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647462/optical-coherence-tomography-angiography-of-macular-features-after-proton-beam-radiotherapy-for-small-choroidal-melanoma
#8
Alexandre Sellam, Florence Coscas, Livia Lumbroso-Le Rouic, Rémi Dendale, Marco Lupidi, Gabriel Coscas, Laurence Desjardins, Nathalie Cassoux
PURPOSE: To describe the macular features of patients treated with proton beam therapy for choroidal melanoma (CM), using the optical coherence tomography-angiography (OCTA). DESIGN: Retrospective case-control study. METHODS: This study included patients treated with proton beam radiotherapy (PBR) for a small CM. Only patients that had received 100% of the dose 60 GyEBR to the macular area were included in the analysis. All the patients have undergone a full ophthalmological examination including: visual acuity, OCT B-scan and OCTA...
June 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28647449/igrt-and-motion-management-during-lung-sbrt-delivery
#9
REVIEW
Vincent Caillet, Jeremy T Booth, Paul Keall
Patient motion can cause misalignment of the tumour and toxicities to the healthy lung tissue during lung stereotactic body radiation therapy (SBRT). Any deviations from the reference setup can miss the target and have acute toxic effects on the patient with consequences onto its quality of life and survival outcomes. Correction for motion, either immediately prior to treatment or intra-treatment, can be realized with image-guided radiation therapy (IGRT) and motion management devices. The use of these techniques has demonstrated the feasibility of integrating complex technology with clinical linear accelerator to provide a higher standard of care for the patients and increase their quality of life...
June 21, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28647417/recurrent-thromboembolic-events-after-ischemic-stroke-in-patients-with-primary-brain-tumors
#10
Neal S Parikh, Jaclyn E Burch, Hooman Kamel, Lisa M DeAngelis, Babak B Navi
BACKGROUND: Stroke mechanisms and the risk of recurrent thromboembolism are incompletely understood in patients with primary brain tumors. We sought to better delineate these important clinical features. METHODS: We performed a retrospective cohort study of adults with primary brain tumors diagnosed with magnetic resonance imaging-confirmed acute ischemic stroke at the Memorial Sloan Kettering Cancer Center from 2005 to 2015. Study neurologists collected data on patients' cancer history, stroke risk factors, treatments, and outcomes...
June 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28647283/optimal-cooling-strategies-for-players-in-australian-tennis-open-conditions
#11
Grant P Lynch, Julien D Périard, Babette M Pluim, John R Brotherhood, Ollie Jay
OBJECTIVES: We compared the utility of four cooling interventions for reducing heat strain during simulated tennis match-play in an environment representative of the peak conditions possible at the Australian Open (45°C, <10% RH, 475W/m(2) solar radiation). DESIGN: Nine trained males undertook four trials in a climate chamber, each time completing 4 sets of simulated match-play. METHODS: During ITF-mandated breaks (90-s between odd-numbered games; 120-s between sets), either iced towels (ICE), an electric fan (FANdry), a fan with moisture applied to the skin (FANwet), or ad libitum 10°C water ingestion only (CON) was administered...
May 25, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28647212/combined-primary-hepatic-neuroendocrine-carcinoma-and-hepatocellular-carcinoma-with-aggressive-biological-behavior-adverse-clinical-course-a-case-report
#12
Yukihiko Okumura, Kenichi Kohashi, Huanlin Wang, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda
Combined primary hepatic neuroendocrine carcinoma (PHNEC) and hepatocellular carcinoma (HCC) is a very rare malignant hepatic tumor. Its prognosis and histological features are uncertain. Here we report the case of such a tumor in a 70-year-old male Japanese patient with adverse prognosis. The patient underwent a right hepatic lobectomy for a tumor mass that measured 11×10cm in diameter located in the right lobe of the liver, treated with transcatheter arterial chemoembolization (TACE) and percutaneous transhepatic portal vein embolization (PTPE) therapy five weeks before the operation...
June 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28646904/ct-findings-in-patients-with-cabazitaxel-induced-pelvic-pain-and-haematuria-a-case-series
#13
Geethal N Malalagama, Steve Chryssidis, Francis X Parnis
BACKGROUND: Haematuria and pelvic pain are recognized and documented adverse reactions related to Cabazitaxel use. To date there has not been any documentation of imaging findings in patients with this presentation. CASES: We report a case series of five patients who experienced these symptoms while on Cabazitaxel and were all found to have very similar urothelial changes on CT. The patients were noted to have ureteric and renal pelvic dilatation along with urothelial enhancement (in those who had post contrast imaging)...
June 24, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28646895/stereotactic-radiosurgery-versus-whole-brain-radiotherapy-after-intracranial-metastasis-resection-a-systematic-review-and-meta-analysis
#14
REVIEW
Nayan Lamba, Ivo S Muskens, Aislyn C DiRisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J C Verhoeff, Catharina E Kleynen, Timothy R Smith, Rania A Mekary, Marike L Broekman
BACKGROUND: In patients with one to three brain metastases who undergo resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. METHODS: Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after metastasis resection...
June 24, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28646801/the-effects-of-exposure-to-low-frequency-electromagnetic-fields-on-male-fertility
#15
Mahsa Darbandi, Sara Darbandi, Ashok Agarwal, Ralf Henkle, Mohammad Reza Sadeghi
Context • People are increasingly exposed to low frequency (LF) electromagnetic fields (EMFs), mainly from electricity distribution networks and electronic devices. Critics of this widespread exposure believe that it can have detrimental effects on the human body. On the other hand, many in vivo and in vitro studies have claimed that low frequency electromagnetic therapy can function as a form of alternative medicine and that therapists can treat disease by applying electromagnetic radiation or pulsed EMFs to the body or cells...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646777/predicting-improved-optical-water-quality-in-rivers-resulting-from-soil-conservation-actions-on-land
#16
J R Dymond, R J Davies-Colley, A O Hughes, C D Matthaei
Deforestation in New Zealand has led to increased soil erosion and sediment loads in rivers. Increased suspended fine sediment in water reduces visual clarity for humans and aquatic animals and reduces penetration of photosynthetically available radiation to aquatic plants. To mitigate fine-sediment impacts in rivers, catchment-wide approaches to reducing soil erosion are required. Targeting soil conservation for reducing sediment loads in rivers is possible through existing models; however, relationships between sediment loads and sediment-related attributes of water that affect both ecology and human uses of water are poorly understood...
June 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28646774/observations-of-black-carbon-aerosols-characteristics-over-an-urban-environment-radiative-forcing-and-related-implications
#17
Samina Bibi, Khan Alam, Farrukh Chishtie, Humera Bibi, Said Rahman
With observations of black carbon (BC) aerosol concentrations, optical and radiative properties were obtained over the urban city of Karachi during the period of March 2006-December 2008. BC concentrations were continuously measured using an Aethalometer, while optical and radiative properties were estimated through the Optical Properties of Aerosols and Clouds (OPAC) and Santa Barbra DISORT Atmospheric Radiative Transfer (SBDART) models, respectively. For the study period, the measured BC concentrations were higher during January, February and November, while lower during May, June, July and August...
June 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28646736/cell-damage-caused-by-ultraviolet-b-radiation-in-the-desert-cyanobacterium-phormidium-tenue-and-its-recovery-process
#18
Gaohong Wang, Songqiang Deng, Jiafeng Liu, Chaoran Ye, Xiangjun Zhou, Lanzhou Chen
Phormidium tenue, a cyanobacterium that grows in the topsoil of biological soil crusts (BSCs), has the highest recovery rate among desert crust cyanobacteria after exposure to ultraviolet B (UV-B) radiation. However, the mechanism underlying its recovery process is unclear. To address this issue, we measured chlorophyll a fluorescence, generation of reactive oxygen species (ROS), lipid peroxidation, and repair of DNA breakage in P. tenue following exposure to UV-B. We found that UV-B radiation at all doses tested reduced photosynthesis and induced cell damage in P...
June 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28646722/radiation-therapy-utilization-and-outcomes-for-older-women-with-breast-cancer-impact-of-molecular-subtype-and-tumor-grade
#19
Waqar Haque, Denley Ming Kee Yuan, Vivek Verma, E Brian Butler, Bin S Teh, Lee Wiederhold, Sandra Hatch
BACKGROUND: Radiation therapy (RT) utilization for elderly women with respect to human epidermal growth factor receptor 2 (HER2) receptor status has not been evaluated. Our purpose was to determine differences in RT utilization and breast cancer specific survival (BCSS) for elderly breast cancer patients with distinct molecular biomarkers. METHODS: The Surveillance, Epidemiology, and End Results database was queried for women ≥70 years of age diagnosed with T1N0M0 breast cancer between 2010 and 2013 receiving breast conservation...
June 21, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28646688/solar-radiation-and-out-of-hospital-cardiac-arrest-in-japan
#20
Daisuke Onozuka, Akihito Hagihara
BACKGROUND: Although several studies have estimated the effects of temperature on mortality and morbidity, little is known regarding the burden of out-of-hospital cardiac arrest (OHCA) attributable to solar radiation. METHODS: We obtained data for all cases of OHCA and meteorological data reported between 2011 and 2014 in 3 Japanese prefectures: Hokkaido, Ibaraki, and Fukuoka. We first examined the relationship between daily solar radiation and OHCA risk for each prefecture using time-varying distributed lag non-linear models and then pooled the results in a multivariate random-effects meta-analysis...
June 21, 2017: Environmental Pollution
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