Read by QxMD icon Read


Amanda L Lumsden, Richard L Young, Nektaria Pezos, Damien J Keating
BACKGROUND: Huntingtin-associated Protein 1 (HAP1) is expressed in neurons and endocrine cells, and is critical for postnatal survival in mice. HAP1 shares a conserved "HAP1_N" domain with TRAfficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and T27A3.1 (C. elegans). HAP1, TRAK1 and TRAK2 have a degree of common function, particularly regarding intracellular receptor trafficking. However, TRAK1, TRAK2 and Milton (which have a "Milt/TRAK" domain that is absent in human and rodent HAP1) differ in function to HAP1 in that they are mitochondrial transport proteins, while HAP1 has emerging roles in starvation response...
October 13, 2016: BMC Evolutionary Biology
Yu-Ching Cheng, Hung-Chieh Chen, Chen-Hao Wu, Yi-Ying Wu, Ming-His Sun, Wen-Hsien Chen, Jyh-Wen Chai, Clayton Chi-Chang Chen
BACKGROUND: Traditional digital subtraction angiography (DSA) is currently the gold standard diagnostic method for the diagnosis and evaluation of cerebral arteriovenous malformation (AVM) and dural arteriovenous fistulas (dAVF). OBJECTIVES: The aim of this study was to analyze different less invasive magnetic resonance angiography (MRA) images, time-resolved MRA (TR-MRA) and three-dimensional time-of-flight MRA (3D TOF MRA) to identify their diagnostic accuracy and to determine which approach is most similar to DSA...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Samantha Simpson, Anita D'Aprano, Collette Tayler, Siek Toon Khoo, Roxanne Highfold
BACKGROUND: Early detection of developmental problems is important for facilitating access to targeted intervention and maximising its positive effects. The later problems are identified, the more likely that they will become increasingly difficult to ameliorate. Standardised developmental screening tools are known to improve detection rates of developmental problems compared to clinical judgement alone and are widely recommended for use with all children. The Ages and Stages Questionnaire (ASQ-3) is a tool that is widely used in Australia...
August 18, 2016: Early Human Development
Nelly Buron, Mathieu Porceddu, Célestin Roussel, Karima Begriche, Viviane Trak-Smayra, Thomas Gicquel, Bernard Fromenty, Annie Borgne-Sanchez
Pharmaceuticals are found in the environment but the impact of this contamination on human and animal health is poorly known. The liver could be particularly targeted since a significant number of these drugs are hepatotoxic, in particular via oxidative stress and mitochondrial dysfunction. Notably, the latter events can also be observed in liver diseases linked to obesity, so that the obese liver might be more sensitive to drug toxicity. In this study, we determined the effects of a chronic exposure to low doses of pharmaceuticals in wild-type and obese mice, with a particular focus on mitochondrial function...
August 8, 2016: Environmental Toxicology
Monika Mętrak, Ekonomiuk Aneta, Bogusław Wiłkomirski, Tomasz Staszewski, Małgorzata Suska-Malawska
Pine needles are one of the most commonly used bioindicators of polycyclic aromatic hydrocarbons (PAHs) in the environment. Therefore, the main objective of the current research was the assessment of PAHs accumulation potential of Scots pine (Pinus sylvestris L.) needles in comparison to wild rosemary (Rhododendron tomentosum Harmaja) and birch (Betula spp.) leaves. Our study was carried out on three peat bogs subjected to different degree of anthropopression, which gave us also the opportunity to identify local emission sources...
August 2016: Environmental Monitoring and Assessment
Fran Norflus, Jingnan Bu, Evon Guyton, Claire-Anne Gutekunst
The precise role of huntingtin-associated protein 1 (HAP1) is not known, but studies have shown that it is important for early development and survival. A Caenorhabditis elegans ortholog of HAP1, T27A3.1 (also called trak-1), has been found and is expressed in a subset of neurons. Potential behavioral functions of three knockout lines of T27A3.1 were examined. From its suspected role in mice we hypothesize that T27A3.1 might be involved in egg hatching and early growth, mechanosensation, chemosensation, sensitivity to osmolarity, and synaptic transmission...
September 2016: Journal of Neuroscience Research
Bedrana Bitirmis, Digdem Trak, Yasin Arslan, Erdal Kendüzler
Mn(2+) was separated and preconcentrated using both solid-phase extraction (SPE) and a slotted quartz tube (SQT), and detected by a flame atomic absorption spectrometry (FAAS) system. Firstly, Mn(2+) was retained on a column filled with Amberlite CG-120 resin, and then retained Mn(2+) ions on the Amberlite CG-120 resin eluted with 5 mL of 4 mol/L HNO3. This part was called the "first preconcentration step". Furthermore, to determine the Mn(2+) in a walnut sample, the SQT device was also used after the separation and preconcentration of Mn(2+) from the Amberlite CG-120 resin so as to further improve the sensitivity of system...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Yuqing Chen, Kewen Cheng, Xin Zhou
BACKGROUND Pressure support ventilation (PSV) is a standard method for non-invasive home ventilation. A bench study was designed to compare the effectiveness of patient-ventilator inspiratory termination synchronization with automated and conventional triggering in various respiratory mechanics models. MATERIAL AND METHODS Two ventilators, the Respironics V60 and Curative Flexo ST 30, connected to a Hans Rudolph Series 1101 lung simulator, were evaluated using settings that simulate lung mechanics in patients with chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or normal lungs...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Fady Daniel, Viviane Trak-Smayra, Nathalie Ziade
No abstract text is available yet for this article.
April 2016: American Journal of Gastroenterology
Nora Dehina, Peter Josef Hofmann, Thomas Behrends, Anja Eckstein, Lutz Schomburg
BACKGROUND: Selenium (Se) is of importance for regular functioning of the immune system and thyroid gland, and may have a health effect in mild Graves' ophthalmopathy (GO). OBJECTIVE: As the Se status declines in inflammation, we analyzed whether GO activity or severity affects the Se status of patients. METHODS: Serum Se and selenoprotein P (SePP) concentrations were retrospectively determined in 84 consecutive GO patients before treatment and compared to their clinical activity score (CAS) and severity of eye changes (NOSPECS) status, and to the concentrations of autoantibodies targeting the TSH receptor (TRAK) or the IGF1 receptor (IGF1R-aAB)...
March 2016: European Thyroid Journal
Yongbok Kim, Joseph M Modrick, Edward C Pennington, Yusung Kim
The objective of this work is to present commissioning procedures to clinically implement a three-dimensional (3D), image-based, treatment-planning system (TPS) for high-dose-rate (HDR) brachytherapy (BT) for gynecological (GYN) cancer. The physical dimensions of the GYN applicators and their values in the virtual applicator library were varied by 0.4 mm of their nominal values. Reconstruction uncertainties of the titanium tandem and ovoids (T&O) were less than 0.4 mm on CT phantom studies and on average between 0...
2016: Journal of Applied Clinical Medical Physics
Daniela Pelclova, Vladimir Zdimal, Petr Kacer, Zdenka Fenclova, Stepanka Vlckova, Kamila Syslova, Tomas Navratil, Jaroslav Schwarz, Nadezda Zikova, Hana Barosova, Francesco Turci, Martin Komarc, Tomas Pelcl, Jaroslav Belacek, Jana Kukutschova, Sergey Zakharov
Markers of oxidative stress and inflammation were analysed in the exhaled breath condensate (EBC) and urine samples of 14 workers (mean age 43  ±  7 years) exposed to iron oxide aerosol for an average of 10  ±  4 years and 14 controls (mean age 39  ±  4 years) by liquid chromatography-electrospray ionization-mass spectrometry/mass spectrometry (LC-ESI-MS/MS) after solid-phase extraction. Aerosol exposure in the workplace was measured by particle size spectrometers, a scanning mobility particle sizer (SMPS) and an aerodynamic particle sizer (APS), and by aerosol concentration monitors, P-TRAK and DustTRAK DRX...
March 2016: Journal of Breath Research
Judyta Wiercińska, Anna Wronczewska, Renata Kabacińska, Roman Makarewicz
PURPOSE: The purpose of this study is to evaluate our first experience with 3D image-guided breast brachytherapy and to compare dose distribution parameters between Paris dosimetry system (PDS) and image-based plans. MATERIAL AND METHODS: First 49 breast cancer patients treated with 3D high-dose-rate interstitial brachytherapy as a boost were selected for the study. Every patient underwent computed tomography, and the planning target volume (PTV) and organs at risk (OAR) were outlined...
December 2015: Journal of Contemporary Brachytherapy
B Abboud, C Sader Ghorra, M Rassy, S El Naderi, V Trak-Smayra, G Abadjian, A Khaddage
OBJECTIVES: The incidence of papillary thyroid carcinoma increased in several countries. The purpose of this study was to quantify the changes in thyroid carcinomas in our University Hospital. STUDY DESIGN: Retrospective study. METHODS: All 1.927 thyroidectomy cases studied in the Pathology Department of Hotel-Dieu de France Hospital (Beirut, Lebanon), between 2003 and 2013, were included. RESULTS: The Female/Male Sex Ratio of the studied population was 3...
November 2015: Acta Chirurgica Belgica
Bor Luen Tang
The evolutionarily-conserved mitochondrial Rho (MIRO) small GTPase is a Ras superfamily member with three unique features. It has two GTPase domains instead of the one found in other small GTPases, and it also has two EF hand calcium binding domains, which allow Ca(2+)-dependent modulation of its activity and functions. Importantly, it is specifically associated with the mitochondria and via a hydrophobic transmembrane domain, rather than a lipid-based anchor more commonly found in other small GTPases. At the mitochondria, MIRO regulates mitochondrial homeostasis and turnover...
2015: Cells
Fiona Rohlffs, Nikolaos Tsilimparis, Christian Detter, Yskert von Kodolitsch, Sebastian Debus, Tilo Kölbel
PURPOSE: To describe the deployment into the ascending aorta of a fenestrated stent-graft with a scallop for the innominate artery. TECHNIQUE: A 72-year-old multimorbid patient presented with a chronic DeBakey type II aortic dissection of the ventral ascending aorta with close proximity (16 mm) to the innominate artery. A 1-piece, 46-mm-diameter Zenith Ascend Thoracic Endovascular Graft with circumferential diameter-reducing sutures (ProForm) was custom made with a 15×30-mm scallop for the innominate artery...
February 2016: Journal of Endovascular Therapy
Shuang Gao, Roy T McKay, Michael Yermakov, Jinyong Kim, Tiina Reponen, Xinjian He, Kazushi Kimura, Sergey A Grinshpun
The objective of this study was to investigate the protection level offered by a Powered Air-Purifying Respirator (PAPR) equipped with an improperly sized or stretched-out loose-fitting facepiece using constant and cyclic flow conditions. Improperly sized PAPR facepieces of two models as well as a stretched-out facepiece were tested. These facepieces were examined in two versions: with and without exhaust holes. Loose-fitting facepieces (size "large") were donned on a small manikin headform and challenged with sodium chloride (NaCl) aerosol particles in an exposure chamber...
2016: Journal of Occupational and Environmental Hygiene
Rosalind Norkett, Souvik Modi, Nicol Birsa, Talia A Atkin, Davor Ivankovic, Manav Pathania, Svenja V Trossbach, Carsten Korth, Warren D Hirst, Josef T Kittler
The DISC1 protein is implicated in major mental illnesses including schizophrenia, depression, bipolar disorder, and autism. Aberrant mitochondrial dynamics are also associated with major mental illness. DISC1 plays a role in mitochondrial transport in neuronal axons, but its effects in dendrites have yet to be studied. Further, the mechanisms of this regulation and its role in neuronal development and brain function are poorly understood. Here we have demonstrated that DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins Miro1 and Miro2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins)...
January 8, 2016: Journal of Biological Chemistry
Irena Spasić, Kate Button, Anna Divoli, Satyam Gupta, Tamas Pataky, Diego Pizzocaro, Alun Preece, Robert van Deursen, Chris Wilson
BACKGROUND: Standard care for the rehabilitation of knee conditions involves exercise programs and information provision. Current methods of rehabilitation delivery struggle to keep up with large volumes of patients and the length of treatment required to maximize the recovery. Therefore, the development of novel interventions to support self-management is strongly recommended. Such interventions need to include information provision, goal setting, monitoring, feedback, and support groups, but the most effective methods of their delivery are poorly understood...
2015: JMIR Research Protocols
Tanel Traks, Maris Keermann, Maire Karelson, Ranno Rätsep, Ene Reimann, Helgi Silm, Eero Vasar, Sulev Kõks, Külli Kingo
BACKGROUND: The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated response to pathogens, TLRs are involved in inducing inflammatory mediators to combat these threats. It is therefore not surprising that TLRs have been implicated in inflammatory skin diseases, including atopic dermatitis and psoriasis...
2015: Frontiers in Genetics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"