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JOURNAL ARTICLE
Youjun Wu, Chen Ding, Behrang Sharif, Alexis Weinreb, Grace Swaim, Hongyan Hao, Shaul Yogev, Shigeki Watanabe, Marc Hammarlund
Mitochondria transport is crucial for axonal mitochondria distribution and is mediated by kinesin-1-based anterograde and dynein-based retrograde motor complexes. While Miro and Milton/TRAK were identified as key adaptors between mitochondria and kinesin-1, recent studies suggest the presence of additional mechanisms. In C. elegans, ric-7 is the only single gene described so far, other than kinesin-1, that is absolutely required for axonal mitochondria localization. Using CRISPR engineering in C. elegans, we find that Miro is important but is not essential for anterograde traffic, whereas it is required for retrograde traffic...
May 6, 2024: Journal of Cell Biology
#2
JOURNAL ARTICLE
Naveen Thimmaiah, Vishal Malavade, Uday Krishna A S, Sathiyan S, Tanvir Pasha C R, Lokesh Vishwanath
OBJECTIVE: We aim to compare TRAK & TPS based isodose volumes in cervical cancer brachytherapy and assess the feasibility, accuracy and potential future implications of TRAK in this regard and as a newer emerging tool to assess treatment intensity in cervical cancer brachytherapy. METHODS: one hundred patients with histologically proven squamous cell carcinoma of cervix uteri were assessed for brachytherapy (after completion of external radiation) and prospectively enrolled for the study...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#3
JOURNAL ARTICLE
Claudia Michaelis, Tamara M I Berger, Kirill Kuhlmann, Rangina Ghulam, Lukas Petrowitsch, Maria Besora Vecino, Bernd Gesslbauer, Tea Pavkov-Keller, Walter Keller, Elisabeth Grohmann
Conjugation is a major mechanism that facilitates the exchange of antibiotic resistance genes among bacteria. The broad-host-range Inc18 plasmid pIP501 harbors 15 genes that encode for a type IV secretion system (T4SS). It is a membrane-spanning multiprotein complex formed between conjugating donor and recipient cells. The penultimate gene of the pIP501 operon encodes for the cytosolic monomeric protein TraN. This acts as a transcriptional regulator by binding upstream of the operon promotor, partially overlapping with the origin of transfer...
2024: Frontiers in Molecular Biosciences
#4
JOURNAL ARTICLE
Christian Covill-Cooke, Brian Kwizera, Guillermo López-Doménech, Caleb Od Thompson, Ngaam J Cheung, Ema Cerezo, Martin Peterka, Josef T Kittler, Benoît Kornmann
Miro proteins are universally conserved mitochondrial calcium-binding GTPases that regulate a multitude of mitochondrial processes, including transport, clearance, and lipid trafficking. The exact role of Miro in these functions is unclear but involves binding to a variety of client proteins. How this binding is operated at the molecular level and whether and how it is important for mitochondrial health, however, remains unknown. Here, we show that known Miro interactors-namely, CENPF, Trak, and MYO19-all use a similar short motif to bind the same structural element: a highly conserved hydrophobic pocket in the first calcium-binding domain of Miro...
January 24, 2024: EMBO Journal
#5
JOURNAL ARTICLE
Yasin Arslan, Fatma Tomul, Neslihan Kaya Kınaytürk, Nguyen Thanh Dong, Diğdem Trak, Burcu Kabak, Hai Nguyen Tran
Commercial micro-mesoporous carbonaceous material (MCM; 56.8% mesopores) was applied for investigating the removal phenomenon of naproxen drug in aqueous solutions through batch adsorption experiments. Results demonstrated that the adsorption capacity of MCM to naproxen was slightly affected by different pHeq (2.0-11) and ionic strength (0-1 M NaCl). Adsorption kinetics, isotherms, thermodynamics, and mechanisms were evaluated at pH 7.0. Adsorption kinetics indicated the rate constants for adsorption (0...
January 2024: Water Environment Research: a Research Publication of the Water Environment Federation
#6
JOURNAL ARTICLE
Hiroki Matsuno, Takashi Izumi, Masahiro Nishihori, Shunsaku Goto, Yoshio Araki, Kinya Yokoyama, Kenji Uda, Ryuta Saito
We conducted a study to understand the characteristics of the finishing coils to select the appropriate coil for the final stage of embolization. Consequently, experimental embolization was performed on a 10 mm spherical silicone aneurysm filled with radiolucent coils, which simulated a volume embolization ratio of 20%. Nine different coils (i-ED complex ∞ SilkySoft, SilkySoft, ExtraSoft, V-Trak HyperSoft helical, Barricade 10 complex finishing, Optima complex 10 soft, Target 360 Ultra, Galaxy G3 mini, and Axium prime 3D ExtraSoft) were analyzed six times at random...
November 2023: Nagoya Journal of Medical Science
#7
JOURNAL ARTICLE
Kadri Orro, Kristiina Salk, Anna Merkulova, Kristi Abram, Maire Karelson, Tanel Traks, Toomas Neuman, Pieter Spee, Külli Kingo
Measurements of skin surface biomarkers have enormous value for the detailed assessment of skin conditions, both for clinical application and in skin care. The main goals of the current study were to assess whether expression patterns of skin surface hBD-1, hBD-2, IL-1α, CXCL-1, and CXCL-8, examples of proteins known to be involved in psoriasis pathology, are associated with disease severity and whether expression patterns of these proteins on the skin surface can be used to measure pharmacodynamic effects of biological therapy...
November 13, 2023: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Elana E Baltrusaitis, Erika E Ravitch, Adam R Fenton, Tania Perez, Erika L F Holzbaur, Roberto Dominguez
MIRO (mitochondrial Rho GTPase) consists of two GTPase domains flanking two Ca2+ -binding EF-hand domains. A C-terminal transmembrane helix anchors MIRO to the outer mitochondrial membrane, where it functions as a general adaptor for the recruitment of cytoskeletal proteins that control mitochondrial dynamics. One protein recruited by MIRO is TRAK (trafficking kinesin-binding protein), which in turn recruits the microtubule-based motors kinesin-1 and dynein-dynactin. The mechanism by which MIRO interacts with TRAK on the mitochondrial membrane is not well understood...
November 8, 2023: Journal of Biological Chemistry
#9
REVIEW
Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders.
Dengfeng Lu, Yun Feng, Guangjie Liu, Yayi Yang, Yubo Ren, Zhouqing Chen, Xiaoou Sun, Yixiang Guan, Zhong Wang
Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke...
2023: Frontiers in Neuroscience
#10
Nick Dand, Philip E Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R Saklatvala, Maris Teder-Laving, Laurent F Thomas, Tanel Traks, Steffen Uebe, Gunter Assmann, David Baudry, Frank Behrens, Allison C Billi, Matthew A Brown, Harald Burkhardt, Francesca Capon, Raymond Chung, Charles J Curtis, Michael Duckworth, Eva Ellinghaus, Oliver FitzGerald, Sascha Gerdes, Christopher E M Griffiths, Susanne Gulliver, Philip Helliwell, Pauline Ho, Per Hoffmann, Oddgeir L Holmen, Zhi-Ming Huang, Kristian Hveem, Deepak Jadon, Michaela Köhm, Cornelia Kraus, Céline Lamacchia, Sang Hyuck Lee, Feiyang Ma, Satveer K Mahil, Neil McHugh, Ross McManus, Ellen H Modalsli, Michael J Nissen, Markus Nöthen, Vinzenz Oji, Jorge R Oksenberg, Matthew T Patrick, Bethany E Perez-White, Andreas Ramming, Jürgen Rech, Cheryl Rosen, Mrinal K Sarkar, Georg Schett, Börge Schmidt, Trilokraj Tejasvi, Heiko Traupe, John J Voorhees, Eike Matthias Wacker, Richard B Warren, Rachael Wasikowski, Stephan Weidinger, Xiaoquan Wen, Zhaolin Zhang, Anne Barton, Vinod Chandran, Tõnu Esko, John Foerster, Andre Franke, Dafna D Gladman, Johann E Gudjonsson, Wayne Gulliver, Ulrike Hüffmeier, Külli Kingo, Sulev Kõks, Wilson Liao, Mari Løset, Reedik Mägi, Rajan P Nair, Proton Rahman, André Reis, Catherine H Smith, Paola Di Meglio, Jonathan N Barker, Lam C Tsoi, Michael A Simpson, James T Elder
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci. To move towards a saturation map of psoriasis susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls and identified 109 distinct psoriasis susceptibility loci, including 45 that have not been previously reported...
October 5, 2023: medRxiv
#11
JOURNAL ARTICLE
M Cem Şirin, Yasemin Cezaroğlu, E Sesli Çetin, Buket Arıdoğan, Diğdem Trak, Yasin Arslan
The progressive increase in infections caused by multidrug-resistant (MDR) Gram-negative bacteria and the emergence of resistance to last-resort antimicrobial drugs in recent years necessitate the development of new therapeutic strategies. This study was conducted to obtain nanostructured antimicrobials by conjugating colistin (COL) and meropenem (MEM) antibiotics with biosynthesized silver nanoparticles (bio-AgNPs) via the green synthesis method using Rosa damascena extract, and to investigate the antibacterial and antibiofilm activity of these nanostructures against Escherichia coli and Klebsiella pneumoniae strains...
October 11, 2023: Journal of Basic Microbiology
#12
JOURNAL ARTICLE
R Yaparpalvi, A Rivera, S Viswanathan, J Tang, W A Tome, K J Mehta
PURPOSE/OBJECTIVE(S): To study TRAK and its association with dosimetric parameters in template-based high dose-rate interstitial brachytherapy in advanced gynecologic cancers. MATERIALS/METHODS: Brachytherapy treatment plans of 53 patients treated between 2012 and 2022 at our institution with template-based Iridium-192 HDR brachytherapy, post-external beam RT, for locally advanced cancers of the cervix and vagina were retrospectively reviewed. Brachytherapy dose ranged from 25 to 30-Gy delivered in 4 to 6 fractions...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#13
JOURNAL ARTICLE
Mohammad Daher, Ziad Zalaquett, Elio Mekhael, Marven Aoun, Ralph Chalhoub, Majd Abdo, Marc Aoude, Sami Abi Farraj, Ali Ghoul, Jean Tarchichi, Joe Rassi, Amer Sebaaly, Viviane Trak-Smayra, Carole Kesrouani, Hampig-Raphaël Kourie, Ismat Ghanem
AIM: Bone tumors are rare and have an uneven geographic distribution. METHODS: 730 patients diagnosed with bone tumors were included in this retrospective analysis. RESULTS: With a 64% rate of malignancy, the most common tumors were metastasis (40%) mostly in the axial skeleton, Osteosarcoma (9%) mostly in the femur, Osteochondroma (8%) mostly in the femur, giant cell tumors (7%) mostly in the knee, and Ewing's sarcoma (6%) mostly in the axial skeleton...
October 2023: Future Science OA
#14
JOURNAL ARTICLE
Sarah Nasr, Fadi G Haddad, Joseph Khazen, Joseph Kattan, Viviane Trak-Smayra
INTRODUCTION: Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced urothelial carcinoma (UC) in the frontline and relapsed settings. Lebanon has one of the highest incidence of UC worldwide, yet no data exists regarding the expression of PD-L1 by Combined Positive Score (CPS) in advanced disease. METHODS: We reviewed all patients treated at our institution for high grade UC, stage pT2 and above, between January 2017 and March 2021...
September 1, 2023: BMC Cancer
#15
JOURNAL ARTICLE
Natalia Balestra, Suzanne Fredericks, Adryel Vieira Caetano da Silva, Roberta Cunha Matheus Rodrigues, Daniella Pires Nunes, Rafaela Batista Dos Santos Pedrosa
BACKGROUND: Patients with long-term ventricular assist devices (VAD) are predisposed to infection, bleeding, and pressure injuries at the insertion of the driveline. There is no consensus on a driveline dressing protocol. Chlorhexidine is often used to clean the driveline exit site and has been associated with lower rates of infection. For driveline coverage, bacteriostatic agents and transparent film have shown good results, but are costly. The same issue was associated with anchorage devices...
August 24, 2023: Heart & Lung: the Journal of Critical Care
#16
Youjun Wu, Chen Ding, Alexis Weinreb, Laura Manning, Grace Swaim, Shaul Yogev, Daniel A Colón-Ramos, Marc Hammarlund
UNLABELLED: Mitochondria transport is crucial for mitochondria distribution in axons and is mediated by kinesin-1-based anterograde and dynein-based retrograde motor complexes. While Miro and Milton/TRAK were identified as key adaptors between mitochondria and kinesin-1, recent studies suggest the presence of additional mechanisms. In C. elegans , ric-7 is the only single gene described so far, other than kinesin-1, that is absolutely required for axonal mitochondria localization. Using CRISPR engineering in C...
July 12, 2023: bioRxiv
#17
JOURNAL ARTICLE
Anita D'Aprano, Sue-Anne Hunter, Rebecca Fry, Melissa Savaglio, Sarah Carmody, John Boffa, Louise Cooke, Abigail Dent, Amanda Docksey, Josie Douglas, Adam Dunn, Nick Halfpenny, Meg Hewett, Adrienne Lipscomb, Esmai Manahan, Belinda Morton, Holly Mosse, Dawn Ross, Helen Skouteris
ISSUE ADDRESSED: The ASQ-TRAK, a strengths-based approach to developmental screening, has high acceptability and utility across varied Aboriginal and Torres Strait Islander contexts. While substantive knowledge translation has seen many services utilise ASQ-TRAK, we now need to move beyond distribution and support evidence-based scale-up to ensure access. Through a co-design approach, we aimed to (1) understand community partners' perspectives of barriers and enablers to ASQ-TRAK implementation and (2) develop an ASQ-TRAK implementation support model to inform scale-up...
July 11, 2023: Health Promotion Journal of Australia
#18
JOURNAL ARTICLE
Harjot Kaur Bajwa, Rohith Singareddy, Anil Kumar Talluri, Heena Kauser, Devender Reddy Boja, G Srikanth, Alluri Krishnam Raju, Nvn Madhusudhana Sresty, Vyshnavi Mytri
PURPOSE: To report the feasibility of performing hybrid intra-cavitary and interstitial (IC/IS) brachytherapy in patients with carcinoma cervix under trans-rectal ultrasound (TRUS) guidance. MATERIAL AND METHODS: All patients who received an external beam radiotherapy (EBRT) dose of 50 Gy in 25 fractions with weekly chemotherapy, followed by a brachytherapy boost (21 Gy in 3 fractions) were prospectively included for analysis. IC/IS brachytherapy was performed using Fletcher style tandem and ovoid applicator with interstitial component under TRUS guidance...
June 2023: Journal of Contemporary Brachytherapy
#19
JOURNAL ARTICLE
Elvira Galimova, Ranno Rätsep, Tanel Traks, Alexandr Chernov, Darya Gaysina, Külli Kingo, Sulev Kõks
BACKGROUND: Skin is a target organ and source of the corticotropin-releasing hormone-proopiomelanocortin (CRH-POMC) system, operating as a coordinator and executor of responses to stress. Environmental stress exacerbates and triggers inflammatory skin diseases through modifying the cellular components of the immune system supporting the importance of CRH-POMC system in the pathogenesis of psoriasis. The aim of this study was to analyze the association of CRH-POMC polymorphisms with psoriasis and evaluate transcript expression of lesional psoriatic and normal skin in RNA-seq data...
June 15, 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
#20
JOURNAL ARTICLE
Marlon D Joseph, Elizabeth E Hatch, Martha R Koenig, Michael L Eisenberg, Tanran R Wang, Greg J Sommer, Sherri O Stuver, Kenneth J Rothman, Lauren A Wise
OBJECTIVE: To evaluate the association between anthropometric measures and semen parameters. DESIGN: Cross-sectional study. SUBJECTS: Male participants aged ≥21 years. We analyzed data from 659 males (1185 samples) participating in a semen testing substudy of the Pregnancy Online Study (PRESTO), a North American preconception cohort study. After enrollment, we invited males aged ≥21 years to perform at-home semen testing using the Trak system...
May 8, 2023: Fertility and Sterility
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