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https://www.readbyqxmd.com/read/28867617/total-reference-air-kerma-can-accurately-predict-isodose-surface-volumes-in-cervix-cancer-brachytherapy-a-multicenter-study
#1
Karen S Nkiwane, Else Andersen, Jerome Champoudry, Astrid de Leeuw, Jamema Swamidas, Jacob Lindegaard, Richard Pötter, Christian Kirisits, Kari Tanderup
PURPOSE: To demonstrate that V60 Gy, V75 Gy, and V85 Gy isodose surface volumes can be accurately estimated from total reference air kerma (TRAK) in cervix cancer MRI-guided brachytherapy (BT). METHODS AND MATERIALS: 60 Gy, 75 Gy, and 85 Gy isodose surface volumes levels were obtained from treatment planning systems (VTPS) for 239 EMBRACE study patients from five institutions treated with various dose rates, fractionation schedules and applicators. An equation for estimating VTPS from TRAK was derived...
August 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28702760/regulation-of-long-distance-transport-of-mitochondria-along-microtubules
#2
REVIEW
Anna Melkov, Uri Abdu
Mitochondria are cellular organelles of crucial importance, playing roles in cellular life and death. In certain cell types, such as neurons, mitochondria must travel long distances so as to meet metabolic demands of the cell. Mitochondrial movement is essentially microtubule (MT) based and is executed by two main motor proteins, Dynein and Kinesin. The organization of the cellular MT network and the identity of motors dictate mitochondrial transport. Tight coupling between MTs, motors, and the mitochondria is needed for the organelle precise localization...
July 12, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28655429/a-study-of-the-correlation-between-ultrafine-particle-emissions-in-motorcycle-smoke-and-mice-erythrocyte-damages
#3
Arinto Y P Wardoyo, Unggul P Juswono, Johan A E Noor
Sharply increasing of motor vehicles every year contributes to amounts of ultrafine particles (UFPs) in the air. Besides, the existence of UFPs in the blood may cause erythrocyte damages that subject to shape deformation. This study was aimed to investigate the influence of UFPs in the motorcycle smoke exposed to mice in different concentrations to the erythrocyte damages. The experiments were conducted by injecting the motorcycle smoke with the varied amounts in an experimental chamber (dimension of 30×20×20cm(3)) where the mice were put in advance for exposuring twice a day (100s)...
October 2, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28590997/is-radiography-necessary-for-pediatric-emergency-department-clinicians-to-safely-manage-ankle-injuries
#4
Rohan Angus Ramasubbu
OBJECTIVES: Ankle radiography in the pediatric emergency department exposes a radiosensitive population to harmful ionizing radiation and is costly to health care systems. This study aimed to determine if ankle injuries in children could be managed safely and effectively without radiography. METHODS: This prospective study enrolled 94 patients with ankle injuries between July 14, 2015, and December 16, 2015. Participating clinicians filled out a tick-box questionnaire describing their predicted diagnosis and management...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28585893/performance-of-two-respiratory-protective-devices-used-by-home-attending-health-care-workers-a-pilot-study
#5
Reported By Yousef Elmashae, Sergey A Grinshpun, Tiina Reponen, Michael Yermakov, Robert Riddle
OBJECTIVES: This pilot study aimed at determining the Workplace Protection Factor (WPF) for respiratory protective devices widely used by health care workers to reduce exposure to potentially hazardous aerosols when attending patients in their homes. Two devices were tested, an N95 filtering facepiece respirator (FFR) and a surgical mask (SM). METHODS: Three home-attending health care workers were recruited, medically cleared and fit tested. At the workplace, the aerosol concentrations outside (Cout) and inside (Cin) of the tested respiratory protective device worn by a subject were measured using two simultaneously operating P-Trak condensation particle counters within the particle size range of approximately 20-1,000 nm...
September 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28558284/characterization-of-pm2-5-exposure-concentration-in-transport-microenvironments-using-portable-monitors
#6
Zhiyuan Li, Wenwei Che, H Christopher Frey, Alexis K H Lau, Changqing Lin
Recently, portable monitors have been increasingly used to quantify air pollutant concentrations at high spatiotemporal resolution. A sampling campaign was conducted to measure the fine particulate matter (PM2.5) and carbon monoxide (CO) exposure concentrations in transport microenvironments (TMEs) in Hong Kong in January and June 2015 using TSI DustTrak and Q-Trak portable monitors. The objectives were to: (1) calibrate DustTrak and Q-Trak; (2) evaluate variability between seasons and microenvironments; (3) estimate indoor/outdoor relationships; and (4) determine minimum sample size...
September 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28551312/locally-advanced-cervical-cancer-is-it-relevant-to-report-image-guided-adaptive-brachytherapy-using-point-a-dose
#7
Renaud Mazeron, Sebastien Gouy, Alexandre Escande, Isabelle Dumas, Eleonor Rivin Del Campo, Enrica Bentivegna, Warren Bacorro, Dimitri Lefkopoulos, Eric Deutsch, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To evaluate the usefulness of reporting the point A dose in patients with locally advanced cervical cancer treated with image-guided adaptive brachytherapy (IGABT). METHODS AND MATERIALS: Dosimetric data from patients treated with a combination of chemoradiation and intracavitary IGABT were examined in light of their outcomes. Prescribing followed the Groupe Européen de Curiethérapie-European Society for Radiation Oncology recommendations. All doses were converted in 2-Gy equivalent...
July 2017: Brachytherapy
https://www.readbyqxmd.com/read/28533802/interobserver-variations-of-target-volume-delineation-and-its-impact-on-irradiated-volume-in-accelerated-partial-breast-irradiation-with-intraoperative-interstitial-breast-implant
#8
Ritu Raj Upreti, Ashwini Budrukkar, Tabassum Wadasadawala, Shagun Misra, Lavanya Gurram, Rima Pathak, Deepak D Deshpande
PURPOSE: To investigate the interobserver variations in delineation of lumpectomy cavity (LC) and clinical target volume (CTV), and its impact on irradiated volume in accelerated partial breast irradiation using intraoperative multicatheter brachytherapy. MATERIAL AND METHODS: Delineation of LC and CTV was done by five radiation oncologists on planning computed tomography (CT) scans of 20 patients with intraoperative interstitial breast implant. Cavity visualization index (CVI), four-point index ranging from (0 = poor) to (3 = excellent) was created and assigned by observers for each patient...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28364549/deleterious-variants-in-trak1-disrupt-mitochondrial-movement-and-cause-fatal-encephalopathy
#9
Ortal Barel, May Christine V Malicdan, Bruria Ben-Zeev, Judith Kandel, Hadass Pri-Chen, Joshi Stephen, Inês G Castro, Jeremy Metz, Osama Atawa, Sharon Moshkovitz, Eti Ganelin, Iris Barshack, Sylvie Polak-Charcon, Dvora Nass, Dina Marek-Yagel, Ninette Amariglio, Nechama Shalva, Thierry Vilboux, Carlos Ferreira, Ben Pode-Shakked, Gali Heimer, Chen Hoffmann, Tal Yardeni, Andreea Nissenkorn, Camila Avivi, Eran Eyal, Nitzan Kol, Efrat Glick Saar, Douglas C Wallace, William A Gahl, Gideon Rechavi, Michael Schrader, David M Eckmann, Yair Anikster
Cellular distribution and dynamics of mitochondria are regulated by several motor proteins and a microtubule network. In neurons, mitochondrial trafficking is crucial because of high energy needs and calcium ion buffering along axons to synapses during neurotransmission. The trafficking kinesin proteins (TRAKs) are well characterized for their role in lysosomal and mitochondrial trafficking in cells, especially neurons. Using whole exome sequencing, we identified homozygous truncating variants in TRAK1 (NM_001042646:c...
March 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28340080/measuring-pm2-5-ultrafine-particles-air-nicotine-and-wipe-samples-following-the-use-of-electronic-cigarettes
#10
Paul Melstrom, Bartosz Koszowski, Meridith Hill Thanner, Eunha Hoh, Brian King, Rebecca Bunnell, Tim McAfee
Background: Few studies have examined the extent of inhalation or dermal contact among bystanders following short-term, secondhand e-cigarette exposure. Objective: Measure PM2.5 (particles <2.5 microns), UF (ultrafine particles <100nm), and nicotine in air and deposited on surfaces and clothing pre-/during/post- a short-term (two-hour) e-cigarette exposure. Methods: E-cigarettes were used ad libitum by three experienced users for two hours during two separate sessions (disposable e-cigarettes, then tank-style e-cigarettes, or "tanks") in a 1858ft3 room...
March 9, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28300646/developmental-changes-in-trak-mediated-mitochondrial-transport-in-neurons
#11
Omar Loss, F Anne Stephenson
Previous studies established that the kinesin adaptor proteins, TRAK1 and TRAK2, play an important role in mitochondrial transport in neurons. They link mitochondria to kinesin motor proteins via a TRAK acceptor protein in the mitochondrial outer membrane, the Rho GTPase, Miro. TRAKs also associate with enzyme, O-linked N-acetylglucosamine transferase (OGT), to form a quaternary, mitochondrial trafficking complex. A recent report suggested that TRAK1 preferentially controls mitochondrial transport in axons of hippocampal neurons whereas TRAK2 controls mitochondrial transport in dendrites...
April 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28196936/influences-of-duration-of-inspiratory-effort-respiratory-mechanics-and-ventilator-type-on-asynchrony-with-pressure-support-and-proportional-assist-ventilation
#12
Renata S Vasconcelos, Raquel P Sales, Luíz H de P Melo, Liégina S Marinho, Vasco Pd Bastos, Andréa da Nc Nogueira, Juliana C Ferreira, Marcelo A Holanda
BACKGROUND: Pressure support ventilation (PSV) is often associated with patient-ventilator asynchrony. Proportional assist ventilation (PAV) offers inspiratory assistance proportional to patient effort, minimizing patient-ventilator asynchrony. The objective of this study was to evaluate the influence of respiratory mechanics and patient effort on patient-ventilator asynchrony during PSV and PAV plus (PAV+). METHODS: We used a mechanical lung simulator and studied 3 respiratory mechanics profiles (normal, obstructive, and restrictive), with variations in the duration of inspiratory effort: 0...
May 2017: Respiratory Care
https://www.readbyqxmd.com/read/28150860/interleukin-10-family-cytokines-pathway-genetic-variants-and-psoriasis
#13
E Galimova, R Rätsep, T Traks, K Kingo, V Escott-Price, S Kõks
BACKGROUND: Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20 and IL-24 have been implicated in autoimmune diseases and we have previously reported that genetic variants in the IL10 gene cluster were associated with psoriasis. OBJECTIVES: To analyse the relationship between genetic polymorphisms in the IL10 gene cluster and psoriasis. This study also explores whether there are gene-gene interactions among these genetic polymorphisms. METHODS: A total of 377 patients with psoriasis and 403 matched healthy controls were enrolled to carry out a case-control study for 48 single-nucleotide polymorphisms (SNPs) of the IL10 gene cluster...
February 2, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28048473/we-de-201-11-sensitivity-and-specificity-of-verification-methods-based-on-total-reference-air-kerma-trak-or-on-user-provided-dose-points-for-graphically-planned-skin-hdr-brachytherapy
#14
A Damato, P Devlin, M Bhagwat, I Buzurovic, J Hansen, D O'Farrell, R Cormack
PURPOSE: To investigate the sensitivity and specificity of a novel verification methodology for image-guided skin HDR brachytherapy plans using a TRAK-based reasonableness test, compared to a typical manual verification methodology. METHODS: Two methodologies were used to flag treatment plans necessitating additional review due to a potential discrepancy of 3 mm between planned dose and clinical target in the skin. Manual verification was used to calculate the discrepancy between the average dose to points positioned at time of planning representative of the prescribed depth and the expected prescription dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27919864/taxonomy-for-the-rehabilitation-of-knee-conditions-trak-a-digital-intervention-to-support-the-self-care-components-of-anterior-cruciate-ligament-rehabilitation-protocol-of-a-feasibility-study
#15
Emma Dunphy, Fiona L Hamilton, Kate Button
BACKGROUND: Rupture of the anterior cruciate ligament (ACL) is common, especially in the active population. In defining the problem of ACL rehabilitation, this study draws from the knowledge that improved self-care, strength, and fitness are associated with better outcomes. Traditional rehabilitation involves regular physiotherapy, but it is not clear what the optimal way for delivering rehabilitation is, and it varies widely across the world. Evidence for treatments are discussed in the literature, however standard length of rehabilitation and frequency of appointments are unknown...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27896317/video-game-assisted-physiotherapeutic-scoliosis-specific-exercises-for-idiopathic-scoliosis-case-series-and-introduction-of-a-new-tool-to-increase-motivation-and-precision-of-exercise-performance
#16
Christine Wibmer, Petra Groebl, Alexander Nischelwitzer, Beate Salchinger, Matthias Sperl, Helmut Wegmann, Hans-Peter Holzer, Vinay Saraph
BACKGROUND: It is important to monitor how patients with juvenile and adolescent idiopathic scoliosis comply with their physiotherapeutic scoliosis-specific exercises (PSSE). Physiogame, a newly developed video game using the Game-Trak 3D interactive game controller, combines correct PSSE performance with gaming. It tracks the position of the working limb in 3D space during the exercises as participants aim to hit certain targets and avoid others, and gives direct feedback by stopping the game if the working limb leaves the target 3D space, which is chosen to secure the corrective position according to the Schroth method...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27887718/novel-centrifugal-technology-for-measuring-sperm-concentration-in-the-home
#17
MULTICENTER STUDY
Ulrich Y Schaff, Laura L Fredriksen, Jon G Epperson, Tiffany R Quebral, Sara Naab, Mark J Sarno, Michael L Eisenberg, Greg J Sommer
OBJECTIVE: To evaluate the analytical performance and usability of the Trak Male Fertility Testing System, a semiquantitative (categorical) device recently US Food and Drug Administration (FDA)-cleared for measuring sperm concentration in the home by untrained users. DESIGN: A three-site clinical trial comparing self-reported lay user results versus reference results obtained by computer-aided semen analysis (CASA). SETTING: Simulated home use environments at fertility centers and urologist offices...
February 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27866381/cardiac-magnetic-resonance-imaging-of-patent-ductus-arteriosus-in-three-dogs
#18
Youngjae Lee, Jaihyun Jung, Junyong Park, Jiyoon Jeong, Seokho Jeon, Sunyoung Park, Jinhwa Chang, Ji-Houn Kang, Chulhyun Lee, Dongwoo Chang
Patent ductus arteriosus (PDA) is the most common congenital cardiovascular disorder in dogs and requires an accurate diagnosis for an appropriate treatment. Cardiac MRI (cMRI) has been reported as a method for characterization of canine thoracic vasculature. However, to the authors' knowledge, no published studies describe evaluation of canine PDA through cMRI. Three dogs were selected for this exploratory study. Electrocardiogram gating and breath-hold techniques were performed using a 3T MR scanner. Both black blood imaging and bright blood cine acquisitions were performed...
January 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27822567/lifestyle-modification-intervention-for-overweight-and-obese-hispanic-pregnant-women-development-implementation-lessons-learned-and-future-applications
#19
Roxana Torres, Sandra Soltero, Maria Angelica Trak, Carolyn M Tucker, Keimari Mendez, Maribel Campos, Walter Willett, Marytere Melendez, Mathew W Gillman, Paul W Franks, Kaumudi Joshipura, Jeremy Pomeroy, Cristina Palacios
OBJECTIVES: To describe the development, implementation and lessons learned of lifestyle intervention to promote appropriate gestational weight gain among Hispanic pregnant women. DESIGN: The intervention was informed by an empowerment oriented theoretical framework, and targeted women in the Pregnancy and Early Life Improvement Study. METHODS: The nutrition component consisted of recommendations for total calories, food quantity and improving carbohydrate and fat quality...
August 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27801878/air-pollution-exposure-in-relation-to-the-commute-to-school-a-bradford-uk-case-study
#20
Kim N Dirks, Judith Y T Wang, Amirul Khan, Christopher Rushton
Walking School Buses (WSBs) provide a safe alternative to being driven to school. Children benefit from the contribution the exercise provides towards their daily exercise target, it gives children practical experience with respect to road safety and it helps to relieve traffic congestion around the entrance to their school. Walking routes are designed largely based in road safety considerations, catchment need and the availability of parent support. However, little attention is given to the air pollution exposure experienced by children during their journey to school, despite the commuting microenvironment being an important contributor to a child's daily air pollution exposure...
October 29, 2016: International Journal of Environmental Research and Public Health
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