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https://www.readbyqxmd.com/read/28343302/force-assisted-ultrasound-imaging-system-through-dual-force-sensing-and-admittance-robot-control
#1
Ting-Yun Fang, Haichong K Zhang, Rodolfo Finocchi, Russell H Taylor, Emad M Boctor
PURPOSE: Ultrasound imaging has been a gold standard for clinical diagnoses due to its unique advantages compared to other imaging modalities including: low cost, noninvasiveness, and safeness to the human body. However, the ultrasound scanning process requires applying a large force over extended periods of time, often in uncomfortable postures in order to maintain the desired orientation. This physical requirement over sonographers' careers often leads to musculoskeletal pain and strain injuries...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28343286/a-mimic-of-sexually-motivated-homicide-insect-stings-and-heat-exhaustion-in-a-forest
#2
Nancy X Liu, Michael S Pollanen
We report the case a woman who was found dead in a forest. The body was nude and the position of the body suggested a sexually motivated homicide. We concluded that death was not related to homicide, but was related to the conjunction of environmental factors, including insect stings, and acute psychosis. A medicolegal death investigation with postmortem examination was undertaken to determine cause of death. At the scene, the body was supine with legs spread apart and the knees flexed, exposing the external genitalia...
March 25, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28343102/acoustic-and-hybrid-3d-printed-electrochemical-biosensors-for-the-real-time-immunodetection-of-liver-cancer-cells-hepg2
#3
Samar Damiati, Seta Küpcü, Martin Peacock, Christoph Eilenberger, Mazin Zamzami, Ishtiaq Qadri, Hani Choudhry, Uwe B Sleytr, Bernhard Schuster
This study presents an efficient acoustic and hybrid three-dimensional (3D)-printed electrochemical biosensors for the detection of liver cancer cells. The biosensors function by recognizing the highly expressed tumor marker CD133, which is located on the surface of liver cancer cells. Detection was achieved by recrystallizing a recombinant S-layer fusion protein (rSbpA/ZZ) on the surface of the sensors. The fused ZZ-domain enables immobilization of the anti-CD133 antibody in a defined manner. These highly accessible anti-CD133 antibodies were employed as a sensing layer, thereby enabling the efficient detection of liver cancer cells (HepG2)...
March 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28343087/cad-cam-machining-vs-pre-sintering-in-lab-fabrication-techniques-of-y-tzp-ceramic-specimens-effects-on-their-mechanical-fatigue-behavior
#4
C P Zucuni, L F Guilardi, S Fraga, L G May, G K R Pereira, L F Valandro
This study evaluated the effects of different pre-sintering fabrication processing techniques of Y-TZP ceramic (CAD/CAM Vs. in-lab), considering surface characteristics and mechanical performance outcomes. Pre-sintered discs of Y-TZP ceramic (IPS e.max ZirCAD, Ivoclar Vivadent) were produced using different pre-sintering fabrication processing techniques: Machined- milling with a CAD/CAM system; Polished- fabrication using a cutting device followed by polishing (600 and 1200 SiC papers); Xfine- fabrication using a cutting machine followed by grinding with extra-fine diamond bur (grit size 30 μm); Fine- fabrication using a cutting machine followed by grinding with fine diamond bur (grit size 46 μm); SiC- fabrication using a cutting machine followed by grinding with 220 SiC paper...
March 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28343063/motives-for-illicit-prescription-drug-use-among-university-students-a-systematic-review-and-meta-analysis
#5
REVIEW
Trevor Bennett, Katy Holloway
BACKGROUND: There is a growing body of research on the motives for prescription drug misuse (PDM) among university students. However, the overall findings of this research are hard to decipher. Studies use different methods, they examine different drug types, the motives are phrased in various ways, and the results differ widely. In order to make sense of this body of knowledge, it is necessary to synthesise the results across studies and draw out conclusions. METHODS: The research comprises a systematic review and meta-analysis of studies on the motives of university students for illicit use of four different types of prescription medication (stimulants, analgesics, tranquillisers and sedatives)...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28343010/structural-and-dynamics-studies-of-the-tetr-family-protein-cprb-from-streptomyces-coelicolor-in-complex-with-its-biological-operator-sequence
#6
Hussain Bhukya, Asis K Jana, Neelanjana Sengupta, Ruchi Anand
In Streptomycetes, tetracycline repressor family of transcription regulators (TetR-FTRs) controls various biological processes including antibiotic biosynthesis, cellular morphology and innate resistance. Here, we focus on understanding the structural basis of transcription regulation by CprB, a member of TetR-FTRs from S. coelicolor. CprB is implicated as a receptor of γ-butyrolactones, a class of quorum sensing molecules, responsible for initiating secondary metabolic pathways. In order to understand the molecular mechanism of DNA recognition, the X-ray structure of CprB in complex with its biological relevant operator sequence was solved to a resolution of 3...
March 22, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28342942/the-nature-of-early-astroglial-protection-fast-activation-and-signaling
#7
REVIEW
Julianna Kardos, László Héja, Katalin Jemnitz, Richárd Kovács, Miklós Palkovits
Our present review is focusing on the uniqueness of balanced astroglial signaling. The balance of excitatory and inhibitory signaling within the CNS is mainly determined by sharp synaptic transients of excitatory glutamate (Glu) and inhibitory γ-aminobutyrate (GABA) acting on the sub-second timescale. Astroglia is involved in excitatory chemical transmission by taking up i) Glu through neurotransmitter-sodium transporters, ii) K(+) released due to presynaptic action potential generation, and iii) water keeping osmotic pressure...
March 22, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28342941/is-there-any-crosstalk-between-the-chemotaxis-and-virulence-induction-signaling-in-agrobacterium-tumefaciens
#8
REVIEW
Minliang Guo, Zhiwei Huang, Jing Yang
Agrobacterium tumefaciens, a soil-born phytopathogenic bacterium, is well known as a nature's engineer due to its ability to genetically transform the host by transferring a DNA fragment (called T-DNA) from its Ti plasmid to host-cell genome. To combat the harsh soil environment and seek the appropriate host, A. tumefaciens can sense and be attracted by a large number of chemical compounds released by wounded host. As a member of α-proteobacterium, A. tumefaciens has a chemotaxis system different from that found in Escherichia coli, since many chemoattractants for A...
March 23, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28342908/intestinal-dendritic-cell-licensing-through-tlr4-is-required-for-oral-tolerance-in-allergic-contact-dermatitis
#9
Feriel Hacini-Rachinel, Mercedes Gomez de Agüero, Reem Kanjarawi, Ludovic Moro-Sibilot, Jean-Benoit Le Luduec, Claire Macari, Gilles Boschetti, Emilie Bardel, Philippe Langella, Bertrand Dubois, Dominique Kaiserlian
BACKGROUND: Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLRs)-mediated sensing of the microbiota contributes to gut homeostasis, yet whether it contributes to induction of oral tolerance has not been documented. OBJECTIVE: We examined whether oral tolerance to the contact sensitizer DNFB depends on microbiota/TLRs and evaluated the role of TLR4 on the tolerogenic function of intestinal dendritic cells (DCs)...
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28342875/the-nociception-genes-painless-and-piezo-are-required-for-the-cellular-immune-response-of-drosophila-larvae-to-wasp-parasitization
#10
Yumiko Tokusumi, Tsuyoshi Tokusumi, Robert A Schulz
In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation of Drosophila larvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization...
March 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28342809/identity-and-function-of-a-cardiac-mitochondrial-small-conductance-ca-2-activated-k-channel-splice-variant
#11
Meiying Yang, Amadou K S Camara, Mohammed Aldakkak, Wai-Meng Kwok, David F Stowe
We provide evidence for location and function of a small conductance, Ca(2+)-activated K(+) (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against ischemia/reperfusion (IR) injury; SKCa antagonists worsened IR injury. Intravenous infusion of a SKCa channel agonist/antagonist, respectively, in intact rats was effective in reducing/enhancing regional infarct size induced by coronary artery occlusion...
March 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28342780/a-neural-basis-for-the-visual-sense-of-number-and-its-development-a-steady-state-visual-evoked-potential-study-in-children-and-adults
#12
Joonkoo Park
While recent studies in adults have demonstrated the existence of a neural mechanism for a visual sense of number, little is known about its development and whether such a mechanism exists at young ages. In the current study, I introduce a novel steady-state visual evoked potential (SSVEP) technique to objectively quantify early visual cortical sensitivity to numerical and non-numerical magnitudes of a dot array. I then examine this neural sensitivity to numerical magnitude in children between three and ten years of age and in college students...
March 2, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28342434/-mothers-talk-part-unless-told-of-voluntary-abortion
#13
José Manuel Hernández Garre, Isabel María Aznar Mula, Paloma Echevarría Pérez
The aim of the study was to investigate the experiences linked to the post-abortion syndrome in mothers who have had a voluntary abortion. A phenomenological qualitative approach to collect the experiences of mothers who had voluntarily interrupted their pregnancy was used. The research technique was the semistructured interviews with women who had contacted different association's help of the Murcia region for support after experiencing symptoms consistent with post-abortion syndrome. The testimonies show feminist or utilitarian arguments to justify the decision to abort, they talk about a system, to some extent, mercantilist that has no real intention of giving real life choices...
January 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28342426/optical-and-electrochemical-dual-channel-sensing-of-cu-2-using-functionalized-furo-2-3-d-pyrimidines-2-4-1h-3h-diones
#14
Manoj Kumar, Lokesh Kumar Kumawat, Priyanka Bhatt, Anjali Jha, Shilpi Agarwal, Anuj Sharma, Vinod Kumar Gupta
Owing to their easy accessibility and high degree of structural and functional diversity, many multicomponent reactions (MCRs) have been a rich source of conjugate π-systems, functionalised chromophores (or fluorophore) and redox active molecules. Despite their high explorative potential and practical benefits, only a few MCR products have been so far investigated for their metal sensing abilities. In the present report, two furopyrimidinones (FPys) based molecular systems have been synthesized by [4+1] cycloaddition based MCR sequence...
March 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28342407/music-and-natural-sounds-in-an-auditory-steady-state-response-based-brain-computer-interface-to-increase-user-acceptance
#15
Jeong Heo, Hyun Jae Baek, Seunghyeok Hong, Min Hye Chang, Jeong Su Lee, Kwang Suk Park
Patients with total locked-in syndrome are conscious; however, they cannot express themselves because most of their voluntary muscles are paralyzed, and many of these patients have lost their eyesight. To improve the quality of life of these patients, there is an increasing need for communication-supporting technologies that leverage the remaining senses of the patient along with physiological signals. The auditory steady-state response (ASSR) is an electro-physiologic response to auditory stimulation that is amplitude-modulated by a specific frequency...
March 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28342369/sensing-properties-of-monolayer-borophane-nanosheet-towards-alcohol-vapors-a-first-principles-study
#16
V Nagarajan, R Chandiramouli
The electronic properties of borophane nanosheet and adsorption behavior of three distinct alcohol vapors namely methanol, ethanol and 1-propanol on borophane nanosheet is studied using density functional theory method for the first time. The state-of-the-art provides insights on to the development of new two dimensional materials with the surface passivation on boron nanostructures. The density of states spectrum provides a clear perception on charge transfer upon adsorption of alcohol vapors on borophane nanosheets...
February 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28342355/pd-nanospheres-decorated-reduced-graphene-oxide-with-multi-functions-highly-efficient-catalytic-reduction-and-ultrasensitive-sensing-of-hazardous-4-nitrophenol-pollutant
#17
A T Ezhil Vilian, Sang Rak Choe, Krishnan Giribabu, Sung-Chan Jang, Changhyun Roh, Yun Suk Huh, Young-Kyu Han
We illustrate a facile approach for in situ synthesis of Pd-gum arabic/reduced graphene oxide (Pd-GA/RGO) using GA as the reducing agent, which favors the instantaneous reduction of both Pd ions and GO into Pd nanoparticles (NPs) and RGO. From the morphological analysis of Pd-GA/RGO, we observed highly dispersed spherical 5nm Pd NPs decorated over RGO. The as-synthesized Pd-GA/RGO composite was employed for the catalytic reduction and the electrochemical detection of 4-nitrophenol (4-NP), respectively. The catalytic reduction of 4-NP was highly pronounced for Pd-GA/RGO (5min) when compared to Pd NPs (140min) and Pd/RGO (36min)...
March 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28342309/hierarchical-assembly-of-in2o3-nanoparticles-on-zno-hollow-nanotubes-using-carbon-fibers-as-templates-enhanced-photocatalytic-and-gas-sensing-properties
#18
Na Wei, Hongzhi Cui, Xinzhen Wang, Xiang Xie, Mingliang Wang, Liqiang Zhang, Jian Tian
A novel hollow hierarchical nano-heterostructure consisting of ZnO nanorods coated with In2O3 nanoparticles was prepared using a hydrothermal method combined with an annealing treatment via carbon fiber (CF) templates. Experimental results reveal that the In2O3/ZnO hierarchical composite has a tubular structure with an average diameter of ∼6μm and In2O3 nanoparticles distribute uniformly on the ZnO nanorods. Significantly, the obtained heterostructure shows enhanced visible light photoactivity to methyl orange (MO) degradation and good selectivity and response toward ethanol even at a low detection limit (1ppm)...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28340465/dumbbell-dna-templated-cunps-as-a-nano-fluorescent-probe-for-detection-of-enzymes-involved-in-ligase-mediated-dna-repair
#19
Taiping Qing, Xiaoxiao He, Dinggeng He, Xiaosheng Ye, Jingfang Shangguan, Jinquan Liu, Baoyin Yuan, Kemin Wang
DNA repair processes are responsible for maintaining genome stability. Ligase and polynucleotide kinase (PNK) have important roles in ligase-mediated DNA repair. The development of analytical methods to monitor these enzymes involved in DNA repair pathways is of great interest in biochemistry and biotechnology. In this work, we reported a new strategy for label-free monitoring PNK and ligase activity by using dumbbell-shaped DNA templated copper nanoparticles (CuNPs). In the presence of PNK and ligase, the dumbbell-shaped DNA probe (DP) was locked and could resist the digestion of exonucleases and then served as an efficient template for synthesizing fluorescent CuNPs...
March 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28340464/a-review-on-various-electrochemical-techniques-for-heavy-metal-ions-detection-with-different-sensing-platforms
#20
REVIEW
BabanKumar Bansod, Tejinder Kumar, Ritula Thakur, Shakshi Rana, Inderbir Singh
Heavy metal ions are non-biodegradable and contaminate most of the natural resources occurring in the environment including water. Some of the heavy metals including Lead (Pb), Mercury (Hg), Arsenic (As), Chromium (Cr) and Cadmium (Cd) are considered to be highly toxic and hazardous to human health even at trace levels. This leads to the requirement of fast, accurate and reliable techniques for the detection of heavy metal ions. This review presents various electrochemical detection techniques for heavy metal ions those are user friendly, low cost, provides on-site and real time monitoring as compared to other spectroscopic and optical techniques...
March 18, 2017: Biosensors & Bioelectronics
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