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https://www.readbyqxmd.com/read/28222493/mobilising-culture-against-domestic-violence-in-migrant-and-ethnic-communities-practitioner-perspectives-from-aotearoa-new-zealand
#1
Rachel Simon-Kumar, Priya A Kurian, Faith Young-Silcock, Nirmala Narasimhan
Studies on domestic violence in ethnic minority communities highlight that social norms, family structures and cultural practices are among the key triggers of violence against women. Not surprisingly, most anti-violence interventions in these communities aim to redeem women from the oppressive features of these cultures. More recently, however, emergent scholarship advocates mobilising, rather than erasing, culture within existing anti-violence strategies. This paper explores the nature of culturally informed interventions used by front-line workers...
February 21, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28222489/characterization-of-a-novel-signal-transducer-element-intrinsic-to-class-iiia-b-adenylate-cyclases-and-guanylate-cyclases
#2
Miriam Ziegler, Jens Bassler, Stephanie Beltz, Anita Schultz, Andrei N Lupas, Joachim E Schultz
Adenylate cyclases (ACs) are signalling proteins that produce the second messenger cAMP. Class III ACs comprises four groups (class IIIa-d); of these, class IIIa and IIIb ACs have been identified in bacteria and eukaryotes. Many class IIIa ACs are anchored to membranes via hexahelical domains. In eukaryotic ACs, membrane anchors are well conserved, suggesting that this region possesses important functional characteristics that are as yet unknown. To address this question, we replaced the hexahelical membrane anchor of the mycobacterial AC Rv1625c by the hexahelical quorum-sensing receptor from Legionella, LqsS...
February 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28222409/a-novel-mutation-of-the-calcium-sensing-receptor-gene-in-a-german-subject-with-familial-hypocalciuric-hypercalcemia-and-primary-hyperparathyroidism
#3
Marios Papadakis, Natalie Meurer, Theodora Margariti, Anke Meyer, Norbert Weyerbrock, Cornelia Dotzenrath
OBJECTIVE: The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare. Genetic evidence has demonstrated a causal relationship between FHH and the presence of inactivating mutations in the calcium-sensing receptor gene. METHOD: We herein report a 60-year-old German patient who was referred for hypercalcemia and increased PTH levels found incidentally during normal routine blood tests. RESULTS: The patient underwent surgical exploration and the diagnosis of PHPT was histologically confirmed...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28222367/a-novel-turn-on-fluorescent-strategy-for-sensing-ascorbic-acid-using-graphene-quantum-dots-as-fluorescent-probe
#4
Hua Liu, Weidan Na, Ziping Liu, Xueqian Chen, Xingguang Su
In this paper, a facile and rapid fluorescence turn-on assay for fluorescent detection of ascorbic acid (AA) was developed by using the orange emission graphene quantum dots (GQDs). In the presence of horse radish peroxidase (HRP) and hydrogen peroxide (H2O2), catechol can be oxidized by hydroxyl radicals and converted to o-benzoquinone, which can significantly quench the fluorescence of GQDs. However, when AA present in the system, it can consume part of H2O2 and hydroxyl radicals to inhibit the generation of o-benzoquinone, resulting in fluorescence recovery...
February 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28222285/nociception
#5
W Daniel Tracey
Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival. This process relies on nociceptors, which are specialized neurons that detect and respond to potentially damaging forms of energy - heat, mechanical and chemical - in the environment. Nociceptors accomplish this task through the expression of molecules that function to detect and signal the presence of potential harm. Downstream of the nociceptive sensory input, the neural signals trigger protective (nocifensive) behaviors, and the sensory stimuli that reach the brain may be perceived as painful...
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28222271/pathways-to-lung-cancer-diagnosis-a-qualitative-study-of-patients-and-general-practitioners-about-diagnostic-and-pre-treatment-intervals
#6
Nicole M Rankin, Sarah York, Emily Stone, David Barnes, Deborah McGregor, Michelle Lai, Tim Shaw, Phyllis N Butow
RATIONALE: Pathways to lung cancer diagnosis and treatment are complex. International evidence shows significant variations in pathways. Qualitative research investigating pathways to lung cancer diagnosis rarely considers both patient and general practitioner views simultaneously. OBJECTIVES: To describe the lung cancer diagnostic pathway, focusing on the perspective of patients and general practitioners about diagnostic and pre-treatment intervals. METHODS: This qualitative study of lung cancer patients and general practitioners in Australia used qualitative interviews or a focus group in which participants responded to a semistructured questionnaire designed to explore experiences of the diagnostic pathway...
February 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28222258/a-simple-and-large-scale-strategy-to-prepare-flexible-graphene-tape-electrode
#7
Li Wang, Jie Yu, Yayun Zhang, Han Yang, Longfei Miao, Yonghai Song
A simple and large-scale strategy to prepare flexible graphene tape electrode (GTE) was proposed. The flexible GTE was prepared by a facile peeling method in which a piece of commercial graphite foil was firstly covered by a commercial acrylic transparent tape and then the transparent adhesive tape was quickly torn off from the graphite foil. Scanning electron microscopy results showed that some folded and wrinkled graphene layers stood up on the GTE surface to form three-dimensional (3D) porous graphene foam...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222235/visual-appearance-of-a-virtual-upper-limb-modulates-the-temperature-of-the-real-hand-a-thermal-imaging-study-in-immersive-virtual-reality
#8
G Tieri, A Gioia, M Scandola, E F Pavone, S M Aglioti
To explore the link between Sense of Embodiment (SoE) over a virtual hand and physiological regulation of skin temperature, twenty-four healthy participants were immersed in virtual reality through a Head Mounted Display and had their real limb temperature recorded by means of a high-sensitivity infrared camera. Participants observed a virtual right upper limb (appearing either normally, or with the hand detached from the forearm) or limb-shaped non-corporeal control objects (continuous or discontinuous wooden blocks) from a first-person perspective...
February 21, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28221814/an-amperometric-glucose-sensor-integrated-into-an-insulin-delivery-cannula-in-vitro-and-in-vivo-evaluation
#9
W Kenneth Ward, Gabriel Heinrich, Matthew Breen, Sheila Benware, Nicole Vollum, Kristin Morris, Chad Knutsen, Joseph D Kowalski, Scott Campbell, Jerry Biehler, Mark S Vreeke, Scott M Vanderwerf, Jessica R Castle, Robert S Cargill
BACKGROUND: Labeling prohibits delivery of insulin at the site of subcutaneous continuous glucose monitoring (CGM). Integration of the sensing and insulin delivery functions into a single device would likely increase the usage of CGM in persons with type 1 diabetes. METHODS: To understand the nature of such interference, we measured glucose at the site of bolus insulin delivery in swine using a flexible electrode strip that was laminated to the outer wall of an insulin delivery cannula...
February 21, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28221784/development-of-a-biosensor-concept-to-detect-the-production-of-cluster-specific-secondary-metabolites
#10
Yi-Qian Sun, Tobias Busche, Christian Rückert, Constanze Paulus, Yuriy Rebets, Renata Novakova, Joern Kalinowski, Andriy Luzhetskyy, Jan Kormanec, Olga N Sekurova, Sergey B Zotchev
Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis gene clusters in Streptomyces was developed. Biosynthetic gene clusters for undecylprodigiosin and coelimycin in the genome of Streptomyces lividans TK24, which encoded TetR-like repressors and appeared to be almost "silent" based on the RNA-seq data were chosen for the proof-of-principle studies...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28221778/engineering-iron-responses-in-mammalian-cells-by-signal-induced-protein-proximity
#11
Guihua Zeng, Huanqiu Li, Yongyi Wei, Weimin Xuan, Roushu Zhang, Larisa Elise Breden, Wei Wang, Fu-Sen Liang
A new synthetic biology engineering strategy integrating chemical reactivity sensing and small molecule induced protein dimerization has been developed to generate artificial Fe(2+) signaling circuitry to control tailored cellular events in mammalian cells. The dual function probe ABA-FE18 (Fe(2+)-sensing and protein dimerization) derived from ABA was developed and used to control gene activation, signal transduction and cytoskeletal remodeling in response to Fe(2+). This technology was utilized to design signal circuitry incorporating "AND" and "OR" biologic gates that enables mammalian cells to translate different combinations of Fe(2+) and H2O2 signals into pre-defined biological outputs...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28221774/surface-electronic-state-modulated-single-crystalline-001-tio2-nanosheets-for-sensitive-electrochemical-sensing-of-heavy-metal-ions
#12
Wen-Yi Zhou, Jinyun Liu, Jieyao Song, Jinjin Li, Jinhuai Liu, Xing-Jiu Huang
Intrinsically low conductivity and poor reactivity restrict many semiconductors from electrochemical detection. Usually, metal- and carbon-based modifications of semiconductors are necessary, making them complex, expensive, and unstable. Here, for the first time, we present a surface-electronic-state-modulation-based concept applied to semiconductors. This concept enables pure semiconductors to be directly available for ultrasensitive electrochemical detection of heavy-metal ions without any modifications. As an example, a defective single-crystalline (001) TiO2 nanosheet exhibits high electrochemical performance toward Hg(II), including a sensitivity of 270...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28221753/structure-activity-relationships-of-the-competence-stimulating-peptides-csps-in-streptococcus-pneumoniae-reveal-motifs-critical-for-intra-group-and-cross-group-comd-receptor-activation
#13
Yifang Yang, Bimal Koirala, Lucia A Sanchez, Naiya R Phillips, Sally R Hamry, Yftah Tal-Gan
Streptococcus pneumoniae is a highly recombinogenic human pathogen that utilizes the competence stimulating peptide (CSP)-based quorum sensing (QS) circuitry to acquire antibiotic resistance genes from the environment and initiate its attack on the human host. Modulation of QS in this bacterium, either inhibition or activation, can therefore be used to attenuate S. pneumoniae infectivity and slow down pneumococcal resistance development. In this study we set to determine the molecular mechanism that drives CSP:receptor binding and identify CSP-based QS modulators with distinct activity profiles...
February 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28221714/photonic-devices-out-of-equilibrium-transient-memory-signal-propagation-and-sensing
#14
Thomas Heuser, Rémi Merindol, Sebastian Loescher, Aileen Klaus, Andreas Walther
Soft photonic materials are important for sensors, displays, or energy management and have become switchable under static equilibrium conditions by integration of responsive polymer features. The next step is to equip such materials with the ability for autonomously dynamic and self-regulating behavior, which would advance their functionality and application possibilities to new levels. Here, this study shows the system integration of a nonlinear, biocatalytic pH-feedback system with a pH-responsive block copolymer photonic gel, and demonstrates autonomous transient memories, remotely controlled signal propagation, and sensing...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28221091/journal-of-personality-and-social-psychology-attitudes-and-social-cognition
#15
Shinobu Kitayama
In this editorial, the new incoming editor for the Journal of Personality and Social Psychology (JPSP)addresses the upcoming challenges and the issue of replicability. Although people vary (often dramatically) in their views on the nature and extent of this issue, that we have an issue to address is something that the new editor thinks most scholars would agree on. It is her hope that engaging in these efforts will return our community to a place that young talent willingly and safely bets their futures on...
March 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28221023/polymorph-dependent-electrogenerated-chemiluminescence-of-low-dimensional-organic-semiconductor-structures-for-sensing
#16
Jianmin Gu, Yahui Gao, Jingxiao Wu, Qing Li, Aixue Li, Wei Zhang, Haiyun Dong, Bin Wen, Faming Gao, Yong Sheng Zhao
A sensitive electrogenerated chemiluminescence (ECL) sensor with organic semiconductor as active materials for detecting trace amounts of molecules have been highly desired. However, the crystal structure responses of the ECL properties of the organic semiconductor materials, that is structure-property relationship, is not clear, which limits the development of the sensitive ECL sensors. Herein, for the first time, we reported a novel concept for molecular stacking arrangement dependent electrogenerated chemiluminescence properties of organic semiconductor rubrene microstructures...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28221015/taking-orders-from-light-photo-switchable-working-inactive-smart-surfaces-for-protein-and-cell-adhesion
#17
Junji Zhang, Wenjing Ma, Xiao-Peng He, He Tian
Photo-responsive smart surfaces are promising candidates for a variety of applications in optoelectronics and sensing devices. The use of light as an order-signal provides advantages of remote and non-invasive control with high temporal and spatial resolutions. Modification of the photo-switches with target bio-macromolecules, such as peptides, DNA and small-molecules including folic acid derivatives and sugars, has recently become a popular strategy to empower the smart surfaces with an improved detection efficiency and specificity...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28221004/systems-biology-of-oxygen-homeostasis
#18
REVIEW
Debangshu Samanta, Nanduri R Prabhakar, Gregg L Semenza
Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. For further resources related to this article, please visit the WIREs website.
February 21, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28220963/the-association-between-gender-ethnicity-and-suicidality-among-vocational-students-in-israel
#19
Joy Benatov, Ora Nakash, Shai Chen-Gal, Anat Brunstein Klomek
Gender and ethnicity are significant factors when evaluating suicidal risk, especially among ethnically diverse populations. In the current study we explored the association between gender, ethnicity, and suicide ideation and attempts among Arab and Jewish vocational education and training high school students in Israel. Students (N = 3,554) completed a self-report survey evaluating suicide ideation and attempts, depression, anxiety, somatization, and sense of belonging. Hierarchical generalized linear modeling indicated that female Arab adolescents had elevated levels of suicide ideation, higher rates of suicide attempts, and greater psychological distress than Arab males and Jewish students...
February 21, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28220945/off-label-mri-in-2017-of-cieds-a-daily-fork-in-the-road-for-implanters-and-the-case-for-common-sense
#20
EDITORIAL
J Rod Gimbel
Both non-MRI conditional and MRI conditional systems are widely available. Physicians must choose which type of device to place. While off-label MRI can often be done safely, significant administrative and financial burdens remain to the physician posing a significant dilemma as to which device to choose. These issues are reviewed in a detailed direct manner. This article is protected by copyright. All rights reserved.
February 21, 2017: Pacing and Clinical Electrophysiology: PACE
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