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Diffuse tensor imaging

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https://www.readbyqxmd.com/read/28823023/posttraumatic-stress-disorder-symptoms-and-white-matter-abnormalities-among-combat-exposed-veterans
#1
Kirstin Aschbacher, Synthia H Mellon, Owen M Wolkowitz, Clare Henn-Haase, Rachel Yehuda, Janine D Flory, Linda M Bierer, Duna Abu-Amara, Charles R Marmar, Susanne G Mueller
Posttraumatic stress disorder (PTSD) is associated with abnormalities in functional connectivity of a specific cortico-limbic network; however, less is known about white matter abnormalities providing structural connections for this network. This study investigated whether the diagnosis and symptoms of PTSD are associated with alterations in fractional anisotropy (FA), an index reflecting white matter organization, across six, a priori-defined tracts. White matter FA was quantified by diffusion tensor imaging using 3 T-MRI among 57 male, combat-exposed veterans with no history of moderate to severe head injuries or current alcohol dependence: 31 met criteria for PTSD and 26 were demographically comparable, combat-exposed controls without PTSD...
August 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28821748/anxiety-related-experience-dependent-white-matter-structural-differences-in-adolescence-a-monozygotic-twin-difference-approach
#2
Nagesh Adluru, Zhan Luo, Carol A Van Hulle, Andrew J Schoen, Richard J Davidson, Andrew L Alexander, H Hill Goldsmith
Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821657/fronto-parietal-structural-connectivity-in-childhood-predicts-development-of-functional-connectivity-and-reasoning-ability-a-large-scale-longitudinal-investigation
#3
Carter Wendelken, Emilio Ferrer, Simona Ghetti, Stephen Bailey, Laurie Cutting, Silvia A Bunge
Prior research points to a positive concurrent relationship between reasoning ability and both fronto-parietal structural connectivity, as measured by diffusion tensor imaging (e.g. Tamnes et al., 2010), and fronto-parietal functional connectivity, as measured by fMRI (e.g. Cocchi et al., 2014). Further, recent research demonstrates a link between reasoning ability and functional connectivity of two brain regions in particular: rostrolateral prefrontal cortex (RLPFC) and the inferior parietal lobe (IPL) (Wendelken et al...
August 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28818826/test-retest-and-interreader-reproducibility-of-semiautomated-atlas-based-analysis-of-diffusion-tensor-imaging-data-in-acute-cervical-spine-trauma-in-adult-patients
#4
D J Peterson, A M Rutman, D S Hippe, J G Jarvik, F H Chokshi, M R Reyes, C H Bombardier, M Mossa-Basha
BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28818116/distinct-white-matter-microstructural-abnormalities-and-extracellular-water-increases-relate-to-cognitive-impairment-in-alzheimer-s-disease-with-and-without-cerebrovascular-disease
#5
Fang Ji, Ofer Pasternak, Siwei Liu, Yng Miin Loke, Boon Linn Choo, Saima Hilal, Xin Xu, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Juan Zhou
BACKGROUND: Mixed vascular and neurodegenerative dementia, such as Alzheimer's disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment. The brain white matter (WM) microstructural changes in neurodegeneration well-documented by diffusion tensor imaging (DTI) can originate from brain tissue or extracellular free water changes. The differential microstructural and free water changes in AD with and without cerebrovascular disease, especially in normal-appearing WM, remain largely unknown...
August 17, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28817577/detailing-neuroanatomical-development-in-late-childhood-and-early-adolescence-using-noddi
#6
Alyssa Mah, Bryce Geeraert, Catherine Lebel
Diffusion tensor imaging (DTI) studies have provided much evidence of white and subcortical gray matter changes during late childhood and early adolescence that suggest increasing myelination, axon density, and/or fiber coherence. Neurite orientation dispersion and density imaging (NODDI) can be used to further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional DTI. We used measures from NODDI and DTI to examine white and subcortical gray matter development in a group of 27 healthy participants aged 8-13 years...
2017: PloS One
https://www.readbyqxmd.com/read/28817574/diffusion-tensor-imaging-profiles-reveal-specific-neural-tract-distortion-in-normal-pressure-hydrocephalus
#7
Nicole C Keong, Alonso Pena, Stephen J Price, Marek Czosnyka, Zofia Czosnyka, Elise E DeVito, Charlotte R Housden, Barbara J Sahakian, John D Pickard
BACKGROUND: The pathogenesis of normal pressure hydrocephalus (NPH) remains unclear which limits both early diagnosis and prognostication. The responsiveness to intervention of differing, complex and concurrent injury patterns on imaging have not been well-characterized. We used diffusion tensor imaging (DTI) to explore the topography and reversibility of white matter injury in NPH pre- and early after shunting. METHODS: Twenty-five participants (sixteen NPH patients and nine healthy controls) underwent DTI, pre-operatively and at two weeks post-intervention in patients...
2017: PloS One
https://www.readbyqxmd.com/read/28816545/role-of-diffusion-tensor-imaging-in-the-diagnosis-and-management-of-post-traumatic-anosmia
#8
Lilla Bonanno, Silvia Marino, Simona De Salvo, Rosella Ciurleo, Antonio Costa, Daniele Bruschetta, Demetrio Milardi, Galletti Francesco, Placido Bramanti, Fabrizia Caminiti
INTRODUCTION: Anosmia is a possible complication of Traumatic Brain Injury (TBI). Psychometric and electrophysiological methods of olfaction measure and Magnetic Resonance Imaging (MRI) are the tools to evaluate the post-traumatic olfactory loss. Diffusion Tensor Imaging (DTI) provides useful data for a better understanding of etiopathogenesis TBI-related anosmia, in particular the loss of neural connections and their eventual recovery over time. MATERIALS AND METHODS: This study describes a case of TBI-related anosmia...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28815879/calibrated-imaging-reveals-altered-grey-matter-metabolism-related-to-white-matter-microstructure-and-symptom-severity-in-multiple-sclerosis
#9
Nicholas A Hubbard, Monroe P Turner, Minhui Ouyang, Lyndahl Himes, Binu P Thomas, Joanna L Hutchison, Shawheen Faghihahmadabadi, Scott L Davis, Jeremy F Strain, Jeffrey Spence, Daniel C Krawczyk, Hao Huang, Hanzhang Lu, John Hart, Teresa C Frohman, Elliot M Frohman, Darin T Okuda, Bart Rypma
Multiple sclerosis (MS) involves damage to white matter microstructures. This damage has been related to grey matter function as measured by standard, physiologically-nonspecific neuroimaging indices (i.e., blood-oxygen-level dependent signal [BOLD]). Here, we used calibrated functional magnetic resonance imaging and diffusion tensor imaging to examine the extent to which specific, evoked grey matter physiological processes were associated with white matter diffusion in MS. Evoked changes in BOLD, cerebral blood flow (CBF), and oxygen metabolism (CMRO2 ) were measured in visual cortex...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28815853/changes-to-white-matter-microstructure-in-transient-ischemic-attack-a-longitudinal-diffusion-tensor-imaging-study
#10
Jennifer K Ferris, Jodi D Edwards, Jennifer A Ma, Lara A Boyd
Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion-weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28813801/therapeutic-effects-of-an-anti-gravity-locomotor-training-alterg-on-postural-balance-and-cerebellum-structure-in-children-with-cerebral-palsy
#11
A H Rasooli, P M Birgani, Sh Azizi, A Shahrokhi, M M Mirbagheri
We evaluated the therapeutic effects of anti-gravity locomotor treadmill (AlterG) training on postural stability in children with Cerebral Palsy (CP) and spasticity, particularly in the lower extremity. AlterG can facilitate walking by reducing the weight of CP children by up to 80%; it can also help subjects maintain an appropriate posture during the locomotor AlterG training. Thus, we hypothesized that AlterG training, for a sufficient period of time, has a potential to produce cerebellum neuroplasticity, and consequently result in an effective permanent postural stability...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813235/temporary-hearing-threshold-shift-in-healthy-volunteers-with-hearing-protection-caused-by-acoustic-noise-exposure-during-3-t-multisequence-mr-neuroimaging
#12
Chao Jin, Huan Li, Xianjun Li, Miaomiao Wang, Congcong Liu, Jianxin Guo, Jian Yang
Purpose To determine whether a single 51-minute exposure to acoustic noise during 3-T multisequence magnetic resonance (MR) neuroimaging could affect the hearing threshold of healthy adults with earplugs and sponge mats as hearing protection. Materials and Methods With earplugs and motion-refraining sponge mats as hearing protection, 26 healthy young adults underwent 3-T MR neuroimaging imaging that included T1-weighted three-dimensional gradient-echo sequence, T2-weighted fast spin-echo sequence, diffusion-tensor imaging, diffusion-kurtosis imaging, T2*-weighted three-dimensional multiecho gradient-echo sequence, and blood oxygen level-dependent imaging...
August 16, 2017: Radiology
https://www.readbyqxmd.com/read/28813079/diffusion-tensor-imaging-of-brain-white-matter-in-huntington-gene-mutation-individuals
#13
Roberta Arb Saba, James H Yared, Thomas M Doring, Med Phys, Vanderci Borges, Henrique Ballalai Ferraz
Objective: To evaluate the role of the involvement of white matter tracts in huntingtin gene mutation patients as a potential biomarker of the progression of the disease. Methods: We evaluated 34 participants (11 symptomatic huntingtin gene mutation, 12 presymptomatic huntingtin gene mutation, and 11 controls). We performed brain magnetic resonance imaging to assess white matter integrity using diffusion tensor imaging, with measurement of fractional anisotropy...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28812366/a-combination-of-experimental-measurement-constitutive-damage-model-and-diffusion-tensor-imaging-to-characterize-the-mechanical-properties-of-the-human-brain
#14
Alireza Karimi, Seyed Mohammadali Rahmati, Reza Razaghi
Understanding the mechanical properties of the human brain is deemed important as it may subject to various types of complex loadings during the Traumatic Brain Injury (TBI). Although many studies so far have been conducted to quantify the mechanical properties of the brain, there is a paucity of knowledge on the mechanical properties of the human brain tissue and the damage of its axon fibers under the various types of complex loadings during the Traumatic Brain Injury (TBI). Although many studies so far have been conducted to quantify the mechanical properties of the brain, there is a paucity of knowledge on the mechanical properties of the human brain tissue and the damage of its axon fibers under the frontal lobe of the human brain...
August 16, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28812290/a-preliminary-report-of-cerebral-white-matter-microstructural-changes-associated-with-adolescent-sports-concussion-acutely-and-subacutely-using-diffusion-tensor-imaging
#15
Trevor Wu, Tricia L Merkley, Elisabeth A Wilde, Amanda Barnes, Xiaoqi Li, Zili David Chu, Stephen R McCauley, Jill V Hunter, Harvey S Levin
Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI) individuals within 96 h and three months post injury to 12 typically-developing (TD) participants using DTI and volumetric analyses. In terms of volume, no group differences were noted between SC, OI and TD groups at both 96 h and three months post concussion...
August 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28812201/effectiveness-of-navigation-guided-cyst-aspiration-before-resection-of-large-cystic-brain-tumors-a-proof-of-concept-for-more-radical-surgery
#16
Tae Hoon Roh, Kyoung Su Sung, Seok-Gu Kang, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Jong Hee Chang
BACKGROUND: Resection of tumors close to the corticospinal tract (CST) carries a high risk of damage to the CST. For cystic tumors, aspirating the cyst before resection may reduce the risk of damage to vital structures. This study evaluated the effectiveness of cyst aspiration, by comparing the results before and after aspiration of diffusion tensor image (DTI) tractography. METHODS: This study enrolled 23 patients with large cystic brain tumors (>20 cm(3)) between 2012 and 2016...
August 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28809668/tractography-based-score-for-learning-effective-connectivity-from-multimodal-imaging-data-using-dynamic-bayesian-networks
#17
Shilpa Dang, Santanu Chaudhury, Brejesh Lall, Prasun K Roy
OBJECTIVE: Effective connectivity (EC) is the methodology for determining functional-integration among the functionally-active segregated regions of the brain. By definition [1] EC is "the causal influence exerted by one neuronal group on another" which is constrained by anatomical connectivity (AC) (axonal connections). AC is necessary for EC but does not fully determine it, because synaptic communication occurs dynamically in a context-dependent fashion. Although there is a vast emerging evidence of structure-function relationship using multimodal imaging studies, till date only a few studies have done joint modelling of the two modalities: functional MRI (fMRI) and Diffusion Tensor Imaging (DTI)...
August 10, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28805691/structural-and-neuronal-integrity-measures-of-fatigue-severity-in-multiple-sclerosis
#18
Evanthia Bernitsas, Kalyan Yarraguntla, Fen Bao, Rishi Sood, Carla Santiago-Martinez, Rajkumar Govindan, Omar Khan, Navid Seraji-Bozorgzad
Fatigue is a common and disabling symptom in Multiple Sclerosis (MS). However, consistent neuroimaging correlates of its severity are not fully elucidated. In this article, we study the neuronal correlates of fatigue severity in MS. Forty-three Relapsing Remitting MS (RRMS) patients with MS-related fatigue (Fatigue Severity Scale (FSS) range: 1-7) and Expanded Disability Status Scale (EDSS) ≤ 4, were divided into high fatigue (HF, FSS ≥ 5.1) and low fatigue groups (LF, FSS ≤ 3). We measured T2 lesion load using a semi-automated technique...
August 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28802921/imaging-the-nonmotor-symptoms-in-parkinson-s-disease
#19
Tayyabah Yousaf, Heather Wilson, Marios Politis
Parkinson's disease is acknowledged to be a multisystem syndrome, manifesting as a result of multineuropeptide dysfunction, including dopaminergic, cholinergic, serotonergic, and noradrenergic deficits. This multisystem disorder ultimately leads to the presentation of a range of nonmotor symptoms, now appreciated to be an integral part of the disease-specific spectrum of symptoms, often preceding the diagnosis of motor Parkinson's disease. In this chapter, we review the dopaminergic and nondopaminergic basis of these symptoms by exploring the neuroimaging evidence based on several techniques including positron emission tomography, single-photon emission computed tomography molecular imaging, magnetic resonance imaging, functional magnetic resonance imaging, and diffusion tensor imaging...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28799862/disrupted-topologic-efficiency-of-white-matter-structural-connectome-in-individuals-with-subjective-cognitive-decline
#20
Ni Shu, Xiaoni Wang, Qiuhui Bi, Tengda Zhao, Ying Han
Purpose To determine whether individuals with subjective cognitive decline (SCD), which is defined by memory complaints with normal performance at objective neuropsychologic examinations, exhibit disruptions of white matter (WM) connectivity and topologic alterations of the brain structural connectome. Materials and Methods Diffusion-tensor magnetic resonance imaging and graph theory approaches were used to investigate the topologic organization of the brain structural connectome in 36 participants with SCD (21 women: mean age, 62...
August 11, 2017: Radiology
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