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https://www.readbyqxmd.com/read/29683356/is-current-smoking-status-and-its-relationship-to-anti-cyclic-citrullinated-peptide-antibodies-a-predictor-of-worse-response-to-biological-therapies-in-rheumatoid-arthritis-patients
#1
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29549742/metabolism-of-the-synthetic-cannabinoids-amb-chmica-and-5c-akb48-in-pooled-human-hepatocytes-and-rat-hepatocytes-analyzed-by-uhplc-ims-hr-ms-e
#2
Marie Mardal, Petur Weihe Dalsgaard, Bing Qi, Christian Brinch Mollerup, Pieter Annaert, Kristian Linnet
The main analytical targets of synthetic cannabinoids are often metabolites. With the high number of new psychoactive substances entering the market, suitable workflows are needed for analytical target identification in biological samples. The aims of this study were to identify the main metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography-(ion mobility spectroscopy)-high resolution-mass spectrometry in data-independent acquisition mode (UHPLC-(IMS)-HR-MSE )...
March 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29512045/what-to-consider-when-designing-a-laparoscopic-colorectal-training-curriculum-a-review-of-the-literature
#3
REVIEW
A Gaitanidis, C Simopoulos, M Pitiakoudis
Multiple studies have demonstrated the benefits of laparoscopic colorectal surgery (LCS), but in several countries it has still not been widely adopted. LCS training is associated with several challenges, such as patient safety concerns and a steep learning curve. Current evidence may facilitate designing of efficient training curricula to overcome these challenges. Basic training with virtual reality simulators has witnessed meteoric advances and may be essential during the early parts of the learning curve...
March 6, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29505930/hydrogeochemical-and-isotopic-evaluation-of-groundwater-with-elevated-arsenic-in-alkaline-aquifers-in-eastern-punjab-pakistan
#4
Nisbah Mushtaq, Ayesha Younas, Azhar Mashiatullah, Tariq Javed, Arslan Ahmad, Abida Farooqi
Geochemical investigation was carried out for delineating factors responsible for the mobilization of arsenic (As) from aquifer material into the groundwater. Four sites along Ravi River, (Samada, Sarai Chimba, Kot Maiga and Chah Fatehwala), were selected based on the blanket survey. Groundwater-rock interaction and evaporation were the key phenomena controlling groundwater chemistry, as shown by the hydrogeochemical data. Groundwater was predominantly Na-Cl type, with other principle facies being Na-HCO3 , Na-Ca-HCO3 and Ca-Mg-Cl...
February 26, 2018: Chemosphere
https://www.readbyqxmd.com/read/29377755/quality-of-life-outcomes-for-cabozantinib-versus-everolimus-in-patients-with-metastatic-renal-cell-carcinoma-meteor-phase-iii-randomized-trial
#5
David Cella, Bernard Escudier, Nizar M Tannir, Thomas Powles, Frede Donskov, Katriina Peltola, Manuela Schmidinger, Daniel Y C Heng, Paul N Mainwaring, Hans J Hammers, Jae Lyun Lee, Bruce J Roth, Florence Marteau, Paul Williams, John Baer, Milan Mangeshkar, Christian Scheffold, Thomas E Hutson, Sumanta Pal, Robert J Motzer, Toni K Choueiri
Purpose In the phase III METEOR trial ( ClinicalTrials.gov identifier: NCT01865747), 658 previously treated patients with advanced renal cell carcinoma were randomly assigned 1:1 to receive cabozantinib or everolimus. The cabozantinib arm had improved progression-free survival, overall survival, and objective response rate compared with everolimus. Changes in quality of life (QoL), an exploratory end point, are reported here. Patients and Methods Patients completed the 19-item Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI-19) and the five-level EuroQol (EQ-5D-5L) questionnaires at baseline and throughout the study...
January 29, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29304500/dual-oxygen-and-nitrogen-isotopic-characterization-of-the-museum-archived-nitrates-from-the-united-states-of-america-south-africa-and-australia
#6
Chitoshi Mizota, Takahiro Hosono, Midori Matsunaga, Azusa Okumura
Dual (oxygen and nitrogen) isotopic composition of the museum archived nitrates from the United States of America, South Africa and Australia was studied. The analyzed specimens were collected in middle 19th to early 20th centuries, and represent world-wide acquisition of the Smithsonian Institution Natural Museum of Natural History (Washington, D. C., USA) and the Natural History Museum (London, UK). The samples consist of transparent to semi-transparent aggregates of minute nitrate, euhedral crystallites which imply precipitation from percolating fluids under ample space and dry regimes...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29289785/stable-isotopic-composition-reveals-the-spatial-and-temporal-dynamics-of-discharge-in-the-large-river-of-yarlungzangbo-in-the-tibetan-plateau
#7
Wei Ren, Tandong Yao, Shiyou Xie
Spatial and temporal variability in stable isotopic compositions (δ18 O and δD) in river water of the Yarlungzangbo was investigated to identify major hydrological processes along the river channel and evaluate the isotopic response to discharge variation. The results show geographic, distinct isotopic evolutions in the Yarlungzangbo system. Along the main stem, river δ18 O exhibits a decreasing trend from the headwaters to the middle reach but an increasing one from the middle to the lower reaches, and main flows demonstrate much greater δ18 O-δD slope and intercept compared to the global meteoric water line (GMWL) and reported local meteoric water lines (LMWLs) for sites within the basin...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29245376/the-genus-i-diphasia-i-l-agassiz-1862-cnidaria-hydrozoa-in-northwest-africa
#8
Marta Gil, Fran Ramil
This paper is the result of the study of large collections of Sertulariidae Lamouroux, 1812 (Cnidaria, Hydrozoa, Hydroidolina) obtained from continental margins of Northwest Africa by several Spanish and Norwegian surveys between 2004 and 2012. Material collected from Lusitanian seamounts by the French Seamount 1 expedition and from the Great Meteor Bank by the German survey Meteor 42/3 were also examined. A total of 12 species belonging to the genus Diphasia were studied and illustrated, and four new species were described: Diphasia leonisae n...
December 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/29193028/connectivity-in-a-karst-system-using-electrical-resistivity-tomography-and-network-theory
#9
Mariana Gómez-Nicolás, Mario Rebolledo-Vieyra, Efrain Canto-Lugo, Rodrigo Huerta-Quintanilla, Pablo Ochoa-Sandoval
The Ring of Cenotes (RC) is an alignment of numerous cenotes (sinkholes) in a semicircular form (with a radius of 100 km) located in northwestern Yucatán, México. The formation roughly coincides with a concentric ring that corresponds to a buried structure, which has been identified as the product of a meteor impact, known as the Chicxulub crater. Secondary permeability generated by the fracturing and faulting of the sedimentary sequence in the Chicxulub crater has favored the karstification process and therefore the development of underground rivers that transport water from the mainland to the sea...
November 29, 2017: Ground Water
https://www.readbyqxmd.com/read/29166919/similar-short-term-clinical-response-to-high-dose-versus-low-dose-methotrexate-in-monotherapy-and-combination-therapy-in-patients-with-rheumatoid-arthritis
#10
Sytske Anne Bergstra, Cornelia F Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W J Huizinga, Robert B M Landewe
BACKGROUND: Aiming at rapid decrease of disease activity, there has been a trend to start with higher doses of methotrexate (MTX) in patients newly diagnosed with rheumatoid arthritis (RA), both as monotherapy and in combination with other antirheumatic drugs. We aimed to study the relationship between clinical response and MTX dose as monotherapy or combination therapy in patients with early RA. METHODS: Disease-modifying anti-rheumatic drug (DMARD)-naive patients with early RA, from a large international observational database, the METEOR database, were selected if MTX was part of their initial treatment...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29056366/natural-modulators-of-nonalcoholic-fatty-liver-disease-mode-of-action-analysis-and-in-silico-adme-tox-prediction
#11
Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Antonia Diukendjieva, Mattia Mori, Bruno Botta, Ivanka Tsakovska, Ilza Pajeva
Nonalcoholic fatty liver disease (NAFLD) is considered to be the most common chronic liver disease. The discovery of natural product-based NAFLD modulators requires a more comprehensive study of their modes of action (MoAs). In this study we analysed available in the literature data for 26 naturally-derived compounds associated with experimental evidence for NAFLD alleviation and outlined potential biomolecular targets and a network of pharmacological MoAs for 12 compounds with the highest number of experimentally supported MoA key events, modulated by them...
December 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29044494/influence-of-seasonal-pumping-on-groundwater-sources-and-flow-system-nagaoka-plain-japan
#12
Hiroaki Abe, Changyuan Tang, Nozomu Takeuchi, Akihiko Kondoh
Intensive groundwater development in the urban area of the Nagaoka Plain, Japan, has induced changes in the pH and saturation index of calcite in groundwater. To account for these chemical changes, it is important to determine seasonal variations of recharge and the groundwater flow system in the aquifer. This study identified the sources and flow system of groundwater in this urban area by a comprehensive method using stable isotope data and a numerical groundwater model of the Nagaoka Plain. Stable isotope evidence shows that the groundwater is recharged by meteoric water originating from low-elevation areas rather than the mountains surrounding the plain...
October 17, 2017: Ground Water
https://www.readbyqxmd.com/read/28989231/controls-on-the-distribution-of-fluorescent-dissolved-organic-matter-during-an-under-ice-algal-bloom-in-the-western-arctic-ocean
#13
Wilson G Mendoza, Elliot L Weiss, Brian Schieber, B Greg Mitchell
In this study we used fluorescence excitation and emission matrix spectroscopy, hydrographic data, and a self-organizing map (SOM) analysis to assess the spatial distribution of labile and refractory fluorescent dissolved organic matter (FDOM) for the Chukchi and Beaufort Seas at the time of a massive under-ice phytoplankton bloom during early summer 2011. Biogeochemical properties were assessed through decomposition of water property classes and sample classification that employed a SOM neural network-based analysis which classified 10 clusters from 269 samples and 17 variables...
July 2017: Global Biogeochemical Cycles
https://www.readbyqxmd.com/read/28910852/origin-and-evolution-of-aquitard-porewater-in-the-western-coastal-plain-of-bohai-bay-china
#14
Jing Li, Xing Liang, Menggui Jin, Jilong Yang, Bin Ma, Qin Ge
High-salinity paleowater from low-permeability aquitards in coastal areas can be a major threat to groundwater resources; however, such water has rarely been studied. The chemical and isotopic compositions of porewater extracted from a 200-m-thick Quaternary sedimentary sequence in the western coastal plain of Bohai Bay, China, were analyzed to investigate the salinity origin and chemical evolution of porewater in aquitards. Porewater samples derived at depths shallower than 32 m are characterized by Cl-Na type saline water (total dissolved solids [TDS], 10...
November 2017: Ground Water
https://www.readbyqxmd.com/read/28730358/hydrogeochemical-characterization-and-groundwater-quality-assessment-in-intruded-coastal-brine-aquifers-laizhou-bay-china
#15
Xiaoying Zhang, Jinjie Miao, Bill X Hu, Hongwei Liu, Hanxiong Zhang, Zhen Ma
The aquifer in the coastal area of the Laizhou Bay is affected by salinization processes related to intense groundwater exploitation for brine resource and for agriculture irrigation during the last three decades. As a result, the dynamic balances among freshwater, brine, and seawater have been disturbed and the quality of groundwater has deteriorated. To fully understand the groundwater chemical distribution and evolution in the regional aquifers, hydrogeochemical and isotopic studies have been conducted based on the water samples from 102 observation wells...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28709093/evolutionary-process-of-saline-water-intrusion-in-holocene-and-late-pleistocene-groundwater-in-southern-laizhou-bay
#16
Sen Liu, Zhonghua Tang, Maosheng Gao, Guohua Hou
Saline water intrusion is one of the most serious groundwater problems in southern Laizhou Bay. In this study, formation of groundwater with different qualities and saline water intrusion were analyzed using hydrochemical and stable isotopic methods, and the Hydrochemical Facies Evolution Diagram (HFE-Diagram). The results demonstrate that the structure of the sedimentary layer in this area is the dominant controlling factor of groundwater distribution. From the south (land) to the north (sea), the hydrochemical distribution presents a regular changing pattern following the order: HCO3 -Na·Mg and HCO3 ·Cl-Mg·Ca (fresh water), HCO3 ·Cl-Na·Mg (brackish water), Cl-Na·Mg (saline water), Cl-Na (saline water) and Cl·HCO3 -Na (brackish water)...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28702708/microbial-composition-and-diversity-patterns-in-deep-hyperthermal-aquifers-from-the-western-plain-of-romania
#17
Cecilia M Chiriac, Andreea Baricz, Edina Szekeres, Knut Rudi, Nicolae Dragoș, Cristian Coman
A limited number of studies have investigated the biodiversity in deep continental hyperthermal aquifers and its influencing factors. Here, we present the first description of microbial communities inhabiting the Pannonian and Triassic hyperthermal aquifers from the Western Plain of Romania, the first one being considered a deposit of "fossilized waters," while the latter is embedded in the hydrological cycle due to natural refilling. The 11 investigated drillings have an open interval between 952 and 3432 m below the surface, with collected water temperatures ranging between 47 and 104 °C, these being the first microbial communities characterized in deep continental water deposits with outflow temperatures exceeding 80 °C...
January 2018: Microbial Ecology
https://www.readbyqxmd.com/read/28692884/effects-of-hydrated-lime-on-radionuclides-stabilization-of-hanford-tank-residual-waste
#18
Guohui Wang, Wooyong Um, Kirk J Cantrell, Michelle M V Snyder, Mark E Bowden, Mark B Triplett, Edgar C Buck
Chemical stabilization of tank residual waste is part of a Hanford Site tank closure strategy to reduce overall risk levels to human health and the environment. In this study, a set of column leaching experiments using tank C-104 residual waste were conducted to evaluate the leachability of uranium (U) and technetium (Tc) where grout and hydrated lime were applied as chemical stabilizing agents. The experiments were designed to simulate future scenarios where meteoric water infiltrates through the vadose zones into the interior of the tank filled with layers of grout or hydrated lime, and then contacts the residual waste...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28691511/defining-a-stable-water-isotope-framework-for-isotope-hydrology-application-in-a-large-trans-boundary-watershed-russian-federation-ukraine
#19
Yuliya Vystavna, Dmytro Diadin, Frédéric Huneau
Stable isotopes of hydrogen ((2)H) and oxygen ((18)O) of the water molecule were used to assess the relationship between precipitation, surface water and groundwater in a large Russia/Ukraine trans-boundary river basin. Precipitation was sampled from November 2013 to February 2015, and surface water and groundwater were sampled during high and low flow in 2014. A local meteoric water line was defined for the Ukrainian part of the basin. The isotopic seasonality in precipitation was evident with depletion in heavy isotopes in November-March and an enrichment in April-October, indicating continental and temperature effects...
July 10, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28633552/cabozantinib-for-the-treatment-of-kidney-cancer
#20
REVIEW
Ahmed Abdelaziz, Ulka Vaishampayan
Cabozantinib is a small molecule tyrosine kinase inhibitor that initially showed activity in medullary thyroid cancer and was recently approved by the Food and Drug Administration for the treatment of metastatic renal cell carcinoma after progression on first line therapy. Areas covered: In the METEOR trial, cabozantinib demonstrated significantly improved efficacy in all three endpoints; response rates, progression free survival and overall survival in a randomized trial with everolimus as an active comparator...
July 2017: Expert Review of Anticancer Therapy
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