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https://www.readbyqxmd.com/read/29907672/sex-associated-treatment-differences-and-their-outcomes-in-rheumatoid-arthritis-results-from-the-meteor-register
#1
Sytske Anne Bergstra, Cornelia F Allaart, Sofia Ramiro, Arvind Chopra, Nimmisha Govind, Cândida Silva, Elizabeth A Murphy, Robert B M Landewé
OBJECTIVE: To assess differences in initial treatment and treatment response in male and female patients with rheumatoid arthritis (RA) in daily clinical practice. METHODS: The proportion of patients with RA starting different antirheumatic treatments (disease-modifying antirheumatic drugs; DMARD) and the response to treatment were compared in the international, observational METEOR register. All visits from start of the first DMARD until the first DMARD switch or the end of followup were selected...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29898827/ldl-extracellular-vesicle-coagulation-protein-levels-change-after-initiation-of-statin-therapy-findings-from-the-meteor-trial
#2
Laura Verbree-Willemsen, Ya-Nan Zhang, Crystel M Gijsberts, Arjan H Schoneveld, Jiong-Wei Wang, Carolyn S P Lam, Floor Vernooij, Michiel L Bots, Linda M Peelen, Diederick E Grobbee, Joel S Raichlen, Dominique P V de Kleijn
BACKGROUND: Statins are thought to have pleiotropic properties, including anticoagulant effects, in addition to reducing lipoprotein (LDL) levels. Plasma extracellular vesicles (EVs) are small bilayer membrane vesicles involved in various biological processes including coagulation. Since subsets of EVs in the LDL plasma fraction (LDL-EVs) correlate with thrombin activity, we hypothesized that changes in LDL-EVs after statin therapy may differ from that of serum levels of coagulation proteins, providing insight into the effects of statins on coagulation...
May 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29793198/assessment-of-cu-sub-lethal-toxicity-lc-50-in-the-cold-water-gorgonian-dentomuricea-meteor-under-a-deep-sea-mining-activity-scenario
#3
Inês Martins, António Godinho, Joana Goulart, Marina Carreiro-Silva
Previous aquaria-based experiments have shown dissolution and leaching of metals, especially copper (Cu), from the simulated sediment plumes generated during mining activities resulting in a pronounced increase of Cu contamination in the surrounding seawater. Metals are bioavailable to corals with food, through ingestion (particulate phase) and through tissue-facilitated transport (passive diffusion). With corals being particularly vulnerable to metal contamination, resuspension of metal-bearing sediments during mining activities represents an important ecological threat...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29758887/arsenic-rich-shallow-groundwater-in-sandy-aquifer-systems-buffered-by-rising-carbonate-waters-a-geochemical-case-study-from-mannar-island-sri-lanka
#4
U G C Bandara, Saranga Diyabalanage, Christian Hanke, Robert van Geldern, Johannes A C Barth, Rohana Chandrajith
Major ion, trace elements, and stable isotope analyses were performed on groundwater samples collected from Mannar Island in the northern Indian Ocean. Arsenic concentrations up to 34μg/L have been observed in groundwater samples from the island. In addition, 23% of extensively used shallow drinking water wells showed higher arsenic contents than the recommended value by the World Health Organization (10μg/L). Groundwater in the island showed pH values between 6.9 and 8.9 and was dominated by Na+ , K+ , Ca2+ , Mg2+ , HCO3 - , Cl- and SO4 2- ...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757217/caveats-to-exogenous-organic-delivery-from-ablation-dilution-and-thermal-degradation
#5
Chris Mehta, Anthony Perez, Glenn Thompson, Matthew A Pasek
A hypothesis in prebiotic chemistry argues that organics were delivered to the early Earth in abundance by meteoritic sources. This study tests that hypothesis by measuring how the transfer of organic matter to the surface of Earth is affected by energy-dissipation processes such as ablation and airbursts. Exogenous delivery has been relied upon as a source of primordial material, but it must stand to reason that other avenues (i.e., hydrothermal vents, electric discharge) played a bigger role in the formation of life as we know it on Earth if exogenous material was unable to deliver significant quantities of organics...
May 12, 2018: Life
https://www.readbyqxmd.com/read/29753637/safety-and-efficacy-of-cabozantinib-in-metastatic-renal-cell-carcinoma-real-world-data-from-an-italian-managed-access-program
#6
Giuseppe Procopio, Michele Prisciandaro, Roberto Iacovelli, Enrico Cortesi, Giuseppe Fornarini, Gaetano Facchini, Giacomo Cartenì, Roberto Sabbatini, Gabriella Del Bene, Luca Galli, Claudia Caserta, Andrea Giovanni Multari, Marco Bregni, Francesco Massari, Sebastiano Buti, Ugo De Giorgi, Fable Zustovich, Michele Milella, Fabio Calabrò, Maria Laura Mancini, Giampaolo Tortora, Claudio Vernieri, Daniele Santini, Mariella Sorarù, Riccardo Ricotta, Cristina Masini, Marcello Tucci, Stefano Luzi Fedeli, Cinzia Ortega, Antonella Mecozzi, Raffaele Ratta, Cora N Sternberg, Elena Verzoni
BACKGROUND: The randomized phase 3 METEOR study confirmed a survival benefit of cabozantinib over everolimus in patients with metastatic renal-cell carcinoma (mRCC) with disease that progressed after treatment with at least one previous antiangiogenic inhibitor. The aim of this analysis was to evaluate the safety and activity of cabozantinib in an unselected population. METHODS: Data were collected across 24 Italian centers. Cabozantinib therapy was initiated at physician request between September and December 2016...
April 19, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29741047/-stable-hydrogen-and-oxygen-isotope-compositions-in-soil-plant-atmosphere-continuum-spac-in-rocky-mountain-area-of-beijing-china
#7
Wen Ping Deng, Jie Zhang, Zhi Jian Zhang, Shao Chang Hu, Jin Rong Guo, Yuan Qiu Liu, Fan Qian Kong, Yi Zhang
The stable hydrogen and oxygen isotopes are environmental isotopes, which widely exist in various kinds of water. Their relative abundance variation in water can indicate the water circulation and mechanism of water use in plant. This research selected two major kinds of greening tree species, evergreen coniferous Platycladus orientalis and deciduous broad-leaved Quercus variabilis, in Beijing mountainous area, and the water movement process in soil-plant-atmosphere continuum was investigated by the variation characteristics analysis of stable hydrogen and oxygen isotope compositions in precipitation, soil water, groundwater, plant stem water and leaf water...
July 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29719414/cost-effectiveness-comparison-of-cabozantinib-with-everolimus-axitinib-and-nivolumab-in-the-treatment-of-advanced-renal-cell-carcinoma-following-the-failure-of-prior-therapy-in-england
#8
Jie Meng, Johanna Lister, Anne-Lise Vataire, Roman Casciano, Jerome Dinet
Purpose: The aim of this study was to compare the cost-effectiveness of cabozantinib with the standard of care in England in adult patients with advanced renal cell carcinoma (aRCC), following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy. Methods: We developed a partitioned-survival model with three health states to assess the cost-effectiveness of cabozantinib and its comparators. The model time horizon was 30 years. Efficacy and safety data were derived from pivotal clinical trials (METEOR: NCT01865747, CheckMate025: NCT01668784, and AXIS: NCT00678392)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29705640/geochemical-signatures-and-isotopic-systematics-constraining-dynamics-of-fluoride-contamination-in-groundwater-across-jamui-district-indo-gangetic-alluvial-plains-india
#9
S Kumar, A S Venkatesh, Rambabu Singh, G Udayabhanu, D Saha
A data set of 76 water samples are obtained from surface and sub-surface water bodies to investigate chemical parameters and stable isotopic signatures in order to drive factors leading to fluoride (F- ) contamination in groundwater of parts of Jamui district, India. Hydrochemical facies reveals that F- concentration is lower in Ca2+ -HCO3 - facies representative of recharge area, while discharge area has a tendency towards Na+ -HCO3 - facies with elevated F- concentration. The ionic ratios Na+ /Ca2+ >1, Na+ /Cl- >1, (Ca2+ +Mg2+ )/HCO3 - <1, Na+ +K+  = 0...
August 2018: Chemosphere
https://www.readbyqxmd.com/read/29683356/is-current-smoking-status-and-its-relationship-to-anti-cyclic-citrullinated-peptide-antibodies-a-predictor-of-worse-response-to-biological-therapies-in-rheumatoid-arthritis-patients
#10
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29549742/metabolism-of-the-synthetic-cannabinoids-amb-chmica-and-5c-akb48-in-pooled-human-hepatocytes-and-rat-hepatocytes-analyzed-by-uhplc-ims-hr-ms-e
#11
Marie Mardal, Petur Weihe Dalsgaard, Bing Qi, Christian Brinch Mollerup, Pieter Annaert, Kristian Linnet
The main analytical targets of synthetic cannabinoids are often metabolites. With the high number of new psychoactive substances entering the market, suitable workflows are needed for analytical target identification in biological samples. The aims of this study were to identify the main metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography-(ion mobility spectroscopy)-high resolution-mass spectrometry in data-independent acquisition mode (UHPLC-(IMS)-HR-MSE )...
April 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29512045/what-to-consider-when-designing-a-laparoscopic-colorectal-training-curriculum-a-review-of-the-literature
#12
REVIEW
A Gaitanidis, C Simopoulos, M Pitiakoudis
Multiple studies have demonstrated the benefits of laparoscopic colorectal surgery (LCS), but in several countries it has still not been widely adopted. LCS training is associated with several challenges, such as patient safety concerns and a steep learning curve. Current evidence may facilitate designing of efficient training curricula to overcome these challenges. Basic training with virtual reality simulators has witnessed meteoric advances and may be essential during the early parts of the learning curve...
March 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29505930/hydrogeochemical-and-isotopic-evaluation-of-groundwater-with-elevated-arsenic-in-alkaline-aquifers-in-eastern-punjab-pakistan
#13
Nisbah Mushtaq, Ayesha Younas, Azhar Mashiatullah, Tariq Javed, Arslan Ahmad, Abida Farooqi
Geochemical investigation was carried out for delineating factors responsible for the mobilization of arsenic (As) from aquifer material into the groundwater. Four sites along Ravi River, (Samada, Sarai Chimba, Kot Maiga and Chah Fatehwala), were selected based on the blanket survey. Groundwater-rock interaction and evaporation were the key phenomena controlling groundwater chemistry, as shown by the hydrogeochemical data. Groundwater was predominantly Na-Cl type, with other principle facies being Na-HCO3 , Na-Ca-HCO3 and Ca-Mg-Cl...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29377755/quality-of-life-outcomes-for-cabozantinib-versus-everolimus-in-patients-with-metastatic-renal-cell-carcinoma-meteor-phase-iii-randomized-trial
#14
David Cella, Bernard Escudier, Nizar M Tannir, Thomas Powles, Frede Donskov, Katriina Peltola, Manuela Schmidinger, Daniel Y C Heng, Paul N Mainwaring, Hans J Hammers, Jae Lyun Lee, Bruce J Roth, Florence Marteau, Paul Williams, John Baer, Milan Mangeshkar, Christian Scheffold, Thomas E Hutson, Sumanta Pal, Robert J Motzer, Toni K Choueiri
Purpose In the phase III METEOR trial ( ClinicalTrials.gov identifier: NCT01865747), 658 previously treated patients with advanced renal cell carcinoma were randomly assigned 1:1 to receive cabozantinib or everolimus. The cabozantinib arm had improved progression-free survival, overall survival, and objective response rate compared with everolimus. Changes in quality of life (QoL), an exploratory end point, are reported here. Patients and Methods Patients completed the 19-item Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI-19) and the five-level EuroQol (EQ-5D-5L) questionnaires at baseline and throughout the study...
March 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29304500/dual-oxygen-and-nitrogen-isotopic-characterization-of-the-museum-archived-nitrates-from-the-united-states-of-america-south-africa-and-australia
#15
Chitoshi Mizota, Takahiro Hosono, Midori Matsunaga, Azusa Okumura
Dual (oxygen and nitrogen) isotopic composition of the museum archived nitrates from the United States of America, South Africa and Australia was studied. The analyzed specimens were collected in middle 19th to early 20th centuries, and represent world-wide acquisition of the Smithsonian Institution Natural Museum of Natural History (Washington, D. C., USA) and the Natural History Museum (London, UK). The samples consist of transparent to semi-transparent aggregates of minute nitrate, euhedral crystallites which imply precipitation from percolating fluids under ample space and dry regimes...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29289785/stable-isotopic-composition-reveals-the-spatial-and-temporal-dynamics-of-discharge-in-the-large-river-of-yarlungzangbo-in-the-tibetan-plateau
#16
Wei Ren, Tandong Yao, Shiyou Xie
Spatial and temporal variability in stable isotopic compositions (δ18 O and δD) in river water of the Yarlungzangbo was investigated to identify major hydrological processes along the river channel and evaluate the isotopic response to discharge variation. The results show geographic, distinct isotopic evolutions in the Yarlungzangbo system. Along the main stem, river δ18 O exhibits a decreasing trend from the headwaters to the middle reach but an increasing one from the middle to the lower reaches, and main flows demonstrate much greater δ18 O-δD slope and intercept compared to the global meteoric water line (GMWL) and reported local meteoric water lines (LMWLs) for sites within the basin...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29245376/the-genus-i-diphasia-i-l-agassiz-1862-cnidaria-hydrozoa-in-northwest-africa
#17
Marta Gil, Fran Ramil
This paper is the result of the study of large collections of Sertulariidae Lamouroux, 1812 (Cnidaria, Hydrozoa, Hydroidolina) obtained from continental margins of Northwest Africa by several Spanish and Norwegian surveys between 2004 and 2012. Material collected from Lusitanian seamounts by the French Seamount 1 expedition and from the Great Meteor Bank by the German survey Meteor 42/3 were also examined. A total of 12 species belonging to the genus Diphasia were studied and illustrated, and four new species were described: Diphasia leonisae n...
December 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/29193028/connectivity-in-a-karst-system-using-electrical-resistivity-tomography-and-network-theory
#18
Mariana Gómez-Nicolás, Mario Rebolledo-Vieyra, Efrain Canto-Lugo, Rodrigo Huerta-Quintanilla, Pablo Ochoa-Sandoval
The Ring of Cenotes (RC) is an alignment of numerous cenotes (sinkholes) in a semicircular form (with a radius of 100 km) located in northwestern Yucatán, México. The formation roughly coincides with a concentric ring that corresponds to a buried structure, which has been identified as the product of a meteor impact, known as the Chicxulub crater. Secondary permeability generated by the fracturing and faulting of the sedimentary sequence in the Chicxulub crater has favored the karstification process and therefore the development of underground rivers that transport water from the mainland to the sea...
November 29, 2017: Ground Water
https://www.readbyqxmd.com/read/29166919/similar-short-term-clinical-response-to-high-dose-versus-low-dose-methotrexate-in-monotherapy-and-combination-therapy-in-patients-with-rheumatoid-arthritis
#19
Sytske Anne Bergstra, Cornelia F Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W J Huizinga, Robert B M Landewe
BACKGROUND: Aiming at rapid decrease of disease activity, there has been a trend to start with higher doses of methotrexate (MTX) in patients newly diagnosed with rheumatoid arthritis (RA), both as monotherapy and in combination with other antirheumatic drugs. We aimed to study the relationship between clinical response and MTX dose as monotherapy or combination therapy in patients with early RA. METHODS: Disease-modifying anti-rheumatic drug (DMARD)-naive patients with early RA, from a large international observational database, the METEOR database, were selected if MTX was part of their initial treatment...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29056366/natural-modulators-of-nonalcoholic-fatty-liver-disease-mode-of-action-analysis-and-in-silico-adme-tox-prediction
#20
Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Antonia Diukendjieva, Mattia Mori, Bruno Botta, Ivanka Tsakovska, Ilza Pajeva
Nonalcoholic fatty liver disease (NAFLD) is considered to be the most common chronic liver disease. The discovery of natural product-based NAFLD modulators requires a more comprehensive study of their modes of action (MoAs). In this study we analysed available in the literature data for 26 naturally-derived compounds associated with experimental evidence for NAFLD alleviation and outlined potential biomolecular targets and a network of pharmacological MoAs for 12 compounds with the highest number of experimentally supported MoA key events, modulated by them...
December 15, 2017: Toxicology and Applied Pharmacology
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