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Platelet-rich plasma and mesenchymal stem cell

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https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#1
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27818688/modulation-of-synovial-fluid-derived-mesenchymal-stem-cells-by-intra-articular-and-intraosseous-platelet-rich-plasma-administration
#2
Emma Muiños-López, Diego Delgado, Pello Sánchez, Bruno Paiva, Eduardo Anitua, Nicolás Fiz, Beatriz Aizpurua, Jorge Guadilla, Sabino Padilla, Froilán Granero-Moltó, Felipe Prósper, Mikel Sánchez
The aim of this study was to evaluate the effect of intra-articular (IA) or a combination of intra-articular and intraosseous (IO) infiltration of Platelet Rich Plasma (PRP) on the cellular content of synovial fluid (SF) of osteoarthritic patients. Thirty-one patients received a single infiltration of PRP either in the IA space (n = 14) or in the IA space together with two IO infiltrations, one in the medial femoral condyle and one in the tibial plateau (n = 17). SF was collected before and after one week of the infiltration...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27708732/the-role-of-platelet-rich-plasma-prp-and-other-biologics-for-rotator-cuff-repair
#3
Joshua A Greenspoon, Samuel G Moulton, Peter J Millett, Maximilian Petri
BACKGROUND: Surgical treatment of rotator cuff tears has consistently demonstrated good clinical and functional outcomes. However, in some cases, the rotator cuff fails to heal. While improvements in rotator cuff constructs and biomechanics have been made, the role of biologics to aid healing is currently being investigated. METHODS: A selective literature search was performed and personal surgical experiences are reported. RESULTS: Biologic augmentation of rotator cuff repairs can for example be performed wtableith platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs)...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27706690/effects-of-intra-articular-injection-of-mesenchymal-stem-cells-associated-with-platelet-rich-plasma-in-a-rabbit-model-of-osteoarthritis
#4
L C Hermeto, R DeRossi, R J Oliveira, J R Pesarini, A C M B Antoniolli-Silva, P H A Jardim, A E Santana, E Deffune, J C Rinaldi, L A Justulin
The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differentiated into chondrocyte group. Collagenase solution was used to induce osteoarthritis, and treatments were applied to each group at 6 weeks following osteoarthritis induction...
September 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#5
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27656645/magnetic-resonance-imaging-guided-treatment-of-equine-distal-interphalangeal-joint-collateral-ligaments-2009-2014
#6
Nathaniel A White, Jennifer G Barrett
OBJECTIVES: To determine the outcome of treating distal interphalangeal joint collateral ligament (DIJCL) desmopathy using magnetic resonance imaging (MRI)-guided ligament injection. METHODS: Medical records of 13 adult horses diagnosed with DIJCL desmopathy using low-field MRI and treated by MRI-guided ligament injection of mesenchymal stem cells and/or platelet-rich plasma (PRP) were reviewed. Information collected included signalment, MRI diagnosis, treatment type, time to resolution of lameness, and level of exercise after treatment...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27656360/fibrin-scaffold-as-a-carrier-for-mesenchymal-stem-cells-and-growth-factors-in-shoulder-rotator-cuff-repair
#7
Andreas Voss, Mary Beth McCarthy, Donald Allen, Mark P Cote, Knut Beitzel, Andreas B Imhoff, Augustus D Mazzocca
With an increase in the aging population, rotator cuff tears are becoming more common. High failure rates with shoulder rotator cuff repair surgery have been persistent, prompting the introduction of biologic methods to promote healing. The aim of the present technique is to deliver stem cells and growth factors to the footprint of the repair site. A platelet-rich plasma (PRP) fibrin clot is used as a scaffold for the delivery of stem cells, by using PRP, to provide a source of growth factors, and platelet-poor plasma (PPP) as a source for fibrinogen for the matrix for the scaffold...
June 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27641055/the-use-of-adipose-derived-stromal-vascular-fraction-cells-and-platelet-rich-plasma-in-regenerative-plastic-surgery
#8
Pietro Gentile, Maria Giovanna Scioli, Alessandra Bielli, Augusto Orlandi, Valerio Cervelli
Tissue engineering has emerged at the intersection of numerous disciplines to meet a global clinical need for technologies to promote the regeneration of tissues. Recently, many authors have focused their attention on mesenchymal stem/stromal cells (MSCs) for their capacity to differentiate into many cell lineages. The most widely studied cell types are bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ASCs), which display similar results. Biomaterials, cells, and growth factors are needed to design a regenerative plastic surgery approach in the treatment of organ and tissue defects, but not all tissues are created equal...
September 19, 2016: Stem Cells
https://www.readbyqxmd.com/read/27629763/angiogenic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-chondrocyte-brick-enriched-constructs-promoted-stable-regeneration-of-craniofacial-cartilage
#9
Zhiye Li, Ruikai Ba, Zhifa Wang, Jianhua Wei, Yimin Zhao, Wei Wu
: : Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertrophic transition and morphological contraction remain significant challenges. We have developed an "all host derived" cell transplantation system composed of chondrocyte brick (CB)-enriched platelet-rich plasma (P) gel and BMSCs (B)...
September 14, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27605093/combination-of-platelet-rich-plasma-and-bone-marrow-mesenchymal-stem-cells-enhances-tendon-bone-healing-in-a-rabbit-model-of-anterior-cruciate-ligament-reconstruction
#10
Chong Teng, Chenhe Zhou, Danfeng Xu, Fanggang Bi
BACKGROUND: The objective of this study was to investigate the potency of platelet-rich plasma (PRP) combined with bone marrow mesenchymal stem cells (BMSCs) to promote tendon-bone healing in a rabbit model. METHODS: In the in vitro study, the effects of PRP on osteogenic induction of BMSCs were analysed. Later, PRP with or without BMSCs was used in the rabbit model of anterior cruciate ligament reconstruction. Specimens were harvested 8 weeks postoperatively to evaluate tendon-bone healing by histology, radiology, and biomechanical testing...
2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27599200/investigation-of-modified-platelet-rich-plasma-mprp-in-promoting-the-proliferation-and-differentiation-of-dental-pulp-stem-cells-from-deciduous-teeth
#11
J Wen, H T Li, S H Li, X Li, J M Duan
Stem cells from human exfoliated deciduous teeth (SHEDs) have great potential to treat various dental-related diseases in regenerative medicine. They are usually maintained with 10% fetal bovine serum (FBS) in vitro. Modified platelet-rich plasma (mPRP) would be a safe alternative to 10% FBS during SHEDs culture. Therefore, our study aimed to compare the proliferation and differentiation of SHEDs cultured in mPRP and FBS medium to explore an optimal concentration of mPRP for SHEDs maintenance. Platelets were harvested by automatic blood cell analyzer and activated by repeated liquid nitrogen freezing and thawing...
September 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27512216/management-of-osteonecrosis-of-the-femoral-head-a-novel-technique
#12
Ahmed M Samy
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a debilitating disease in orthopedics, frequently progressing to femoral head collapse and osteoarthritis. It is thought to be a multifactorial disease. ONFH ultimately results in femoral head collapse in 75-85% of untreated patients. Total hip arthroplasty (THA) yields satisfactory results in the treatment of the end stage of the disease. However, disease typically affects males between the ages of 20 and 40 years and joint replacement is not the ideal option for younger patients...
July 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27468674/orthobiologic-interventions-using-ultrasound-guidance
#13
REVIEW
Gerard Malanga, Dena Abdelshahed, Prathap Jayaram
The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures...
August 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27462609/combination-of-intra-articular-and-intraosseous-injections-of-platelet-rich-plasma-for-severe-knee-osteoarthritis-a-pilot-study
#14
Mikel Sánchez, Diego Delgado, Pello Sánchez, Emma Muiños-López, Bruno Paiva, Froilán Granero-Moltó, Felipe Prósper, Orlando Pompei, Juan Carlos Pérez, Juan Azofra, Sabino Padilla, Nicolás Fiz
The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27446265/use-of-a-biological-reactor-and-platelet-rich-plasma-for-the-construction-of-tissue-engineered-bone-to-repair-articular-cartilage-defects
#15
Huibo Li, Shui Sun, Haili Liu, Hua Chen, Xin Rong, Jigang Lou, Yunbei Yang, Yi Yang, Hao Liu
Articular cartilage defects are a major clinical burden worldwide. Current methods to repair bone defects include bone autografts, allografts and external fixation. In recent years, the repair of bone defects by tissue engineering has emerged as a promising approach. The present study aimed to assess a novel method using a biological reactor with platelet-rich plasma to construct tissue-engineered bone. Beagle bone marrow mesenchymal stem cells (BMSCs) were isolated and differentiated into osteoblasts and chondroblasts using platelet-rich plasma and tricalcium phosphate scaffolds cultured in a bioreactor for 3 weeks...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27411942/platelet-lysate-as-a-substitute-for-animal-serum-for-the-ex-vivo-expansion-of-mesenchymal-stem-stromal-cells-present-and-future
#16
REVIEW
Giuseppe Astori, Eliana Amati, Franco Bambi, Martina Bernardi, Katia Chieregato, Richard Schäfer, Sabrina Sella, Francesco Rodeghiero
The use of fetal bovine serum (FBS) as a cell culture supplement is discouraged by regulatory authorities to limit the risk of zoonoses and xenogeneic immune reactions in the transplanted host. Additionally, FBS production came under scrutiny due to animal welfare concerns. Platelet derivatives have been proposed as FBS substitutes for the ex-vivo expansion of mesenchymal stem/stromal cells (MSCs) since platelet-derived growth factors can promote MSC ex-vivo expansion. Platelet-derived growth factors are present in platelet lysate (PL) obtained after repeated freezing-thawing cycles of the platelet-rich plasma or by applying physiological stimuli such as thrombin or CaCl2...
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27394438/platelet-rich-plasma-prp-and-adipose-derived-mesenchymal-stem-cells-stimulatory-effects-on-proliferation-and-migration-of-fibroblasts-and-keratinocytes-in-vitro
#17
Talita Stessuk, Maria Beatriz Puzzi, Elinton Adami Chaim, Paulo César Martins Alves, Erich Vinicius de Paula, Andresa Forte, Juliana Massae Izumizawa, Carolina Caliári Oliveira, Fernando Frei, João Tadeu Ribeiro-Paes
The clinical use of tissue engineering associated with cell therapy is considered a new alternative therapy for the repair of chronic lesions with potential application in different medical areas, mostly in orthopedic and dermatological diseases. Platelet-rich plasma (PRP) is a rich source of growth factors and cytokines important for wound healing. Adipose-derived mesenchymal stem cells (ADSCs) have shown potential to accelerate the resolution of ulcers, to stimulate cell proliferation, and to benefit the quality of skin repair...
September 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27306399/mesenchymal-stem-cells-and-growth-factors-used-for-bone-formation-fracture-healing-and-non-unions-a-systematic-review
#18
Katherine L Sinclair, Reza Mafi, Pouya Mafi, Wasim Khan
Aim The aim was to look at current evidence for treating non-unions or delayed fracture healing in regard to novel methods applying mesenchymal stem cells (MSCs) and growth factors (GF). Methods Pre-clinical and clinical trials focusing on the use of Mesenchymal Stem Cells and Growth Factors for fracture healing were included in this review. Published articles were identified using specific search terms in Medline, Cochrane Library, PubMed, Scopus and Web of Science. Results Of the 580 articles found, 82 met my selection criteria and were included, with 39 papers involving trials on the effects of GFs and MSCs on non-unions or bone repair...
June 13, 2016: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27191749/comparison-of-the-early-period-effects-of-bone-marrow-derived-mesenchymal-stem-cells-and-platelet-rich-plasma-on-the-achilles-tendon-ruptures-in-rats
#19
Serdar Yuksel, M Akif Guleç, M Zeki Gultekin, Oktay Adanır, Aysel Caglar, Ozan Beytemur, B Onur Küçükyıldırım, Ali Avcı, Cansu Subaşı, Çiğdem İnci, Erdal Karaoz
INTRODUCTION: This study aims to histopathologically, biomechanically, and immunohistochemically compare the fourth-week efficiencies of local platelet-rich plasma (PRP) and bone marrow-derived mesenchymal stem cell (rBM-MSC) treatments of the Achilles tendon ruptures created surgically in rats. MATERIALS AND METHODS: The study included 35 12-month-old male Sprague Dawley rats, with an average weight of 400-500 g. Five rats were used as donors for MSC and PRP, and 30 rats were separated into MSC, PRP, and control groups (n = 10)...
September 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27135289/platelet-rich-plasma-and-bone-marrow-derived-mesenchymal-stem-cells-in-sports-medicine
#20
Alberto Gobbi, Matthew Fishman
Regenerative medicine is a fast-growing field in orthopedic sports medicine. Platelet-rich plasma contains multiple factors that have been shown to augment healing, thereby stimulating its use in multiple areas of acute and chronic injuries. Mesenchymal stem cells have pluripotent potential to form into tissues pertinent to orthopedics, such as cartilage and bone. As such, there is been a surge in the research directed toward steering those stem cells into a particular lineage as part of treatment for a variety of soft-tissue, cartilage, and bone pathologies...
June 2016: Sports Medicine and Arthroscopy Review
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