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Platelet-rich plasma and mesenchymal stem cell

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https://www.readbyqxmd.com/read/28203597/intra-articular-implantation-of-mesenchymal-stem-cells-part-1-a-review-of-the-literature-for-prevention-of-postmeniscectomy-osteoarthritis
#1
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28194530/application-of-selected-scaffolds-for-bone-tissue-engineering-a-systematic-review
#2
REVIEW
Sepanta Hosseinpour, Mitra Ghazizadeh Ahsaie, Maryam Rezai Rad, Mohammad Taghi Baghani, Saeed Reza Motamedian, Arash Khojasteh
PURPOSE: The current systematic review investigated the results of application of some of the most commonly used scaffolds in conjugation with stem cells and growth factors in animal and clinical studies. METHODS: A comprehensive electronic search was conducted according to the PRISMA guidelines in NCBI PMC and PubMed from January 1970 to December 2015 limited to English language publications with available full texts. In vivo studies in relation to "bone healing," "bone regeneration," and at least one of the following items were investigated: allograft, β-tricalcium phosphate, deproteinized bovine bone mineral, hydroxyapetite/tricalcium phosphate, nanohydroxyapatite, and composite scaffolds...
February 13, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28191761/angiogenic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-chondrocyte-brick-enriched-constructs-promoted-stable-regeneration-of-craniofacial-cartilage
#3
Zhiye Li, Ruikai Ba, Zhifa Wang, Jianhua Wei, Yimin Zhao, Wei Wu
Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertrophic transition and morphological contraction remain significant challenges. We have developed an "all host derived" cell transplantation system composed of chondrocyte brick (CB)-enriched platelet-rich plasma (P) gel and BMSCs (B)...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28191592/what-is-the-clinical-evidence-on-regenerative-medicine-in-intervertebral-disc-degeneration
#4
REVIEW
M Basso, L Cavagnaro, A Zanirato, S Divano, C Formica, M Formica, L Felli
PURPOSE: This review aims to explore and summarize the current clinical evidence about the use of regenerative medicine such as mesenchymal stem cells or platelet-rich plasma in intervertebral disc regeneration, in order to clarify the state of art of these novel approaches. MATERIALS AND METHODS: We performed a research of the available literature about regenerative medicine strategies aiming to prevent intervertebral disc degeneration. All preclinical trials and in vitro studies were excluded...
February 13, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28178294/histological-observation-of-a-gelatin-sponge-transplant-loaded-with-bone-marrow-derived-mesenchymal-stem-cells-combined-with-platelet-rich-plasma-in-repairing-an-annulus-defect
#5
Xiang Xu, Jianzhong Hu, Hongbin Lu
OBJECTIVE: To research the histological characteristics of a gelatin sponge transplant loaded with goat BMSCs (bone marrow-derived mesenchymal stem cells) combined with PRP (platelet-rich plasma) in repairing an annulus defect. METHOD: BMSCs were separated from the iliac crest of goats, sub-cultured and identified after the third generation. Then, PRP was obtained using blood from the jugular vein of goats via two degrees of centrifugation. In the animal experiments, the goats were divided into the following three groups: a sham group, an injury group and a therapeutic group...
2017: PloS One
https://www.readbyqxmd.com/read/28118635/the-effect-of-autologous-platelet-rich-plasma-on-bone-regeneration-by-autologous-mesenchymal-stem-cells-loaded-onto-allogeneic-cancellous-bone-granules
#6
Min Wook Joo, Seung Jae Chung, Seung Han Shin, Yang-Guk Chung
To develop a clinically effective bone regeneration strategy, we compared bone regeneration using allogeneic cancellous bone granule scaffolds loaded with autologous bone marrow-derived mesenchymal stem cells (BM-MSC) with or without autologous platelet-rich plasma (PRP). Critical-sized segmental bone defects were made at the mid-shaft of both radiuses in 41 New Zealand White rabbits. Small-sized allogeneic cancellous bone granules (300-700 μm in diameter) loaded with BM-MSC were implanted on one side, and PRP was added...
January 25, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28116973/human-adipose-derived-mesenchymal-stem-cells-for-osseous-rehabilitation-of-induced-osteoradionecrosis
#7
Jeffrey R Janus, Ryan S Jackson, Katherine A Lees, Stephen G Voss, Zachary C Wilson, Nicholas B Remmes, Michael G Keeney, Joaquin J Garcia, Serban San Marina
Objective Human adipose-derived mesenchymal stem cells (ADSCs) were used to rehabilitate bone damaged by osteoradionecrosis (ORN) in an established animal model. Study Design Prospective animal study. Setting Academic department laboratory. Subjects and Methods After institutional review board and Institutional Animal Care and Use Committee approval, 24 athymic nude rats were divided into 5 groups: 4 groups irradiated (20 Gy) by brachytherapy catheter placed at the left hemimandible and 1 mock irradiation control (n = 4)...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28102000/bone-regeneration-in-minipigs-via-calcium-phosphate-cement-scaffold-delivering-autologous-bmscs-and-platelet-rich-plasma
#8
Gengtao Qiu, Zhanjun Shi, Hockin H K Xu, Bo Yang, Michael D Weir, Guangjun Li, Yang Song, Jixing Wang, Kevin Hu, Ping Wang, Liang Zhao
Macroporous calcium phosphate cement (CPC) with stem cell seeding is promising for bone regeneration. The objective of this study was to investigate the effects of co-delivering autologous bone marrow mesenchymal stem cells (BMSCs) and autologous platelet-rich plasma (PRP) in CPC scaffold for bone regeneration in minipigs for the first time. Twelve female adult Tibet minipigs (12-18 months old) were used. A cylindrical defect with 10 mm height and 8 mm diameter was prepared at the femoral condyle. Two bone defects were created in each minipig, one at each side of the femoral condyle...
January 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#9
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although previous research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28019703/a-clinically-relevant-hydrogel-based-on-hyaluronic-acid-and-platelet-rich-plasma-as-a-carrier-for-mesenchymal-stem-cells-rheological-and-biological-characterization
#10
Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated...
December 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27998240/superparamagnetic-iron-oxide-nanoparticles-in-musculoskeletal-biology
#11
Shama R Iyer, Su Xu, Joseph P Stains, Craig H Bennett, Richard M Lovering
The use of platelet-rich plasma and mesenchymal stem cells has garnered much attention in orthopedic medicine, focusing on the biological aspects of cell function. However, shortly after systemic delivery, or even a local injection, few of the transplanted stem cells or platelets remain at the target site. Improvement in delivery, and the ability to track and monitor injected cells, would greatly improve clinical translation. Nanoparticles can effectively and quickly label most cells in vitro, and evidence to date suggests such labeling does not compromise the proliferation or differentiation of cells...
January 11, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27994625/effect-of-mesenchymal-stem-cells-and-platelet-rich-plasma-on-the-bone-healing-of-ovariectomized-rats
#12
Bo Wei, Chengshuo Huang, Mingyan Zhao, Peng Li, Xiang Gao, Junchao Kong, Yanru Niu, Rui Huang, Juanhua Quan, Jinsong Wei, Jiaqi Chu
We evaluated the efficacy of platelet-rich plasma (PRP) in combination with allogeneic bone marrow mesenchymal stem cells (BMSCs) for the treatment of osteoporotic bone defects in an ovariectomized rat model. By day 42 after injury, in vivo microcomputed tomography (micro-CT) imaging revealed that bone defects of control rats and ovariectomized rats treated with PRP and BMSCs were completely repaired, whereas those of ovariectomized rats treated with PRP or BMSCs alone exhibited slower healing. Histological data were consistent with these results...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27990164/phase-i-ii-trial-of-autologous-bone-marrow-stem-cell-transplantation-with-a-three-dimensional-woven-fabric-scaffold-for-periodontitis
#13
Shunsuke Baba, Yoichi Yamada, Akira Komuro, Yoritaka Yotsui, Makoto Umeda, Kimishige Shimuzutani, Sayaka Nakamura
Regenerative medicine is emerging as a promising option, but the potential of autologous stem cells has not been investigated well in clinical settings of periodontal treatment. In this clinical study, we evaluated the safety and efficacy of a new regenerative therapy based on the surgical implantation of autologous mesenchymal stem cells (MSCs) with a biodegradable three-dimensional (3D) woven-fabric composite scaffold and platelet-rich plasma (PRP). Ten patients with periodontitis, who required a surgical procedure for intrabony defects, were enrolled in phase I/II trial...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#14
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27818688/modulation-of-synovial-fluid-derived-mesenchymal-stem-cells-by-intra-articular-and-intraosseous-platelet-rich-plasma-administration
#15
Emma Muiños-López, Diego Delgado, Pello Sánchez, Bruno Paiva, Eduardo Anitua, Nicolás Fiz, Beatriz Aizpurua, Jorge Guadilla, Sabino Padilla, Froilán Granero-Moltó, Felipe Prósper, Mikel Sánchez
The aim of this study was to evaluate the effect of intra-articular (IA) or a combination of intra-articular and intraosseous (IO) infiltration of Platelet Rich Plasma (PRP) on the cellular content of synovial fluid (SF) of osteoarthritic patients. Thirty-one patients received a single infiltration of PRP either in the IA space (n = 14) or in the IA space together with two IO infiltrations, one in the medial femoral condyle and one in the tibial plateau (n = 17). SF was collected before and after one week of the infiltration...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27708732/the-role-of-platelet-rich-plasma-prp-and-other-biologics-for-rotator-cuff-repair
#16
Joshua A Greenspoon, Samuel G Moulton, Peter J Millett, Maximilian Petri
BACKGROUND: Surgical treatment of rotator cuff tears has consistently demonstrated good clinical and functional outcomes. However, in some cases, the rotator cuff fails to heal. While improvements in rotator cuff constructs and biomechanics have been made, the role of biologics to aid healing is currently being investigated. METHODS: A selective literature search was performed and personal surgical experiences are reported. RESULTS: Biologic augmentation of rotator cuff repairs can for example be performed wtableith platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs)...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27706690/effects-of-intra-articular-injection-of-mesenchymal-stem-cells-associated-with-platelet-rich-plasma-in-a-rabbit-model-of-osteoarthritis
#17
L C Hermeto, R DeRossi, R J Oliveira, J R Pesarini, A C M B Antoniolli-Silva, P H A Jardim, A E Santana, E Deffune, J C Rinaldi, L A Justulin
The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differentiated into chondrocyte group. Collagenase solution was used to induce osteoarthritis, and treatments were applied to each group at 6 weeks following osteoarthritis induction...
September 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#18
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27656645/magnetic-resonance-imaging-guided-treatment-of-equine-distal-interphalangeal-joint-collateral-ligaments-2009-2014
#19
Nathaniel A White, Jennifer G Barrett
OBJECTIVES: To determine the outcome of treating distal interphalangeal joint collateral ligament (DIJCL) desmopathy using magnetic resonance imaging (MRI)-guided ligament injection. METHODS: Medical records of 13 adult horses diagnosed with DIJCL desmopathy using low-field MRI and treated by MRI-guided ligament injection of mesenchymal stem cells and/or platelet-rich plasma (PRP) were reviewed. Information collected included signalment, MRI diagnosis, treatment type, time to resolution of lameness, and level of exercise after treatment...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27656360/fibrin-scaffold-as-a-carrier-for-mesenchymal-stem-cells-and-growth-factors-in-shoulder-rotator-cuff-repair
#20
Andreas Voss, Mary Beth McCarthy, Donald Allen, Mark P Cote, Knut Beitzel, Andreas B Imhoff, Augustus D Mazzocca
With an increase in the aging population, rotator cuff tears are becoming more common. High failure rates with shoulder rotator cuff repair surgery have been persistent, prompting the introduction of biologic methods to promote healing. The aim of the present technique is to deliver stem cells and growth factors to the footprint of the repair site. A platelet-rich plasma (PRP) fibrin clot is used as a scaffold for the delivery of stem cells, by using PRP, to provide a source of growth factors, and platelet-poor plasma (PPP) as a source for fibrinogen for the matrix for the scaffold...
June 2016: Arthroscopy Techniques
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