Rossana Passannante, Vanessa Gómez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossío, Abraham Martín, Jonas Bergare, Lee Kingston, Charles S Elmore, Miguel Angel Morcillo, Pablo Ferrón, Jesus M Aizpurua, Jordi Llop
BACKGROUND AND OBJECTIVE: The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET) is an ideal technique to obtain both biodistribution and pharmacokinetic parameters of new compounds over a wide range of chemical modalities. Here, we use a multi-radionuclide/multi-position labelling approach to investigate distribution, elimination, and metabolism of a triazole-based FKBP12 ligand (AHK2) with potential application in neuromuscular disorders...
January 18, 2023: Biomedicines