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https://www.readbyqxmd.com/read/29054474/deubiquitylating-enzymes-as-cancer-stem-cell-therapeutics
#1
REVIEW
Saba Haq, Bharathi Suresh, Suresh Ramakrishna
The focus of basic and applied research on core stem cell transcription factors has paved the way to initial delineation of their characteristics, their regulatory mechanisms, and the applicability of their regulatory proteins for protein-induced pluripotent stem cells (protein-IPSC) generation and in further clinical settings. Striking parallels have been observed between cancer stem cells (CSCs) and stem cells. For the maintenance of stem cells and CSC pluripotency and differentiation, post translational modifications (i...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29050718/timing-of-changes-in-three-dimensional-spinal-parameters-after-selective-thoracic-fusion-in-lenke-1-adolescent-idiopathic-scoliosis-two-year-follow-up
#2
Saba Pasha, John M Flynn, Paul D Sponseller, Giuseppe Orlando, Peter O Newton, Patrick J Cahill
STUDY DESIGN: Retrospective analysis of the prospectively collected data. OBJECTIVE: To investigate the relationship between the axial rotation of the unfused lumbar spine and the parameters of the instrumented thoracic spine at varying time points after selective thoracic fusion (STF) in Lenke 1B and 1C adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: The impact of STF on the spontaneous lumbar curve correction in AIS has been studied mainly in the frontal planes...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29050686/gender-differences-in-cardiac-resynchronization-therapy-device-choice-and-outcome-in-patients-%C3%A2-75-years-of-age-with-heart-failure
#3
Yanting Wang, Michael S Sharbaugh, Mohammad Bilal Munir, Evan C Adelstein, Norman C Wang, Andrew D Althouse, Samir Saba
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure and can be delivered through a CRT pacemaker (CRT-P) or a CRT defibrillator (CRT-D). CRT-P devices are smaller and less expensive, have better battery longevity, and have been subject to fewer recalls and advisories but cannot deliver high-energy shocks to terminate potentially lethal ventricular arrhythmias. As published guidelines do not distinguish between CRT-P and CRT-D indications, we examined the practice of prescribing these devices in older women and men with heart failure...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#4
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29043205/an-extremely-rare-case-of-concurrent-braf-v600e-mutation-driven-hairy-cell-leukemia-and-melanoma-case-report-and-review-of-literature
#5
Amir Ghorbani-Aghbolaghi, Mirna Lechpammer, Saba F Ali, Nam K Ku, Denis M Dwyre, Hooman H Rashidi
BRAF protein is a serine/threonine kinase with 766 amino acids. Approximately 15% of human cancers harbor BRAF mutations as well as other BRAF anomalies (amplifications, fusions). Somatic mutations mainly occur in the catalytic kinase domain (CR3), and the predominant mutation is p.V600E which is the substitution of glutamic acid (E) for valine (V) as result of a mutation at codon 600 of the kinase domain. To our knowledge, the vast majority of the cancers have non-germline BRAF mutations. Here we describe a case of a 60-year-old female with a history of hairy cell leukemia (HCL) who presented with aphasia and forgetfulness...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29042728/one-stage-full-mouth-disinfection-using-20-propolis-hydroalcoholic-solution-a-clinico-microbiologic-study
#6
Aena Jain Pundir, Anju Vishwanath, Siddharth Pundir, M Swati, Saket Banchhor, Saba Jabee
BACKGROUND: Propolis is a resinous substance produced by honeybees which has many therapeutic properties because of its unique composition. It has been widely used since many years for different medicinal purposes. AIM: The aim of this study was to investigate the effects of one-stage full mouth disinfection (OSFMD) using 20% propolis hydroalcoholic solution in chronic periodontitis patients. MATERIALS AND METHODS: Thirty patients diagnosed with chronic periodontitis and presenting three or more nonadjacent teeth with deep pockets were selected for the study...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29040363/establishing-milestones-for-facial-injectables-in-plastic-surgery-residency-training-four-year-follow-up
#7
Saba Motakef, Insiyah Campwala, Subhas Gupta
No abstract text is available yet for this article.
July 24, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29039328/synergistic-interactions-of-polyphenols-and-their-effect-on-antiradical-potential
#8
Saba Aslam, Nazish Jahan, KhalilUr Rahman, Fatiqa Zafar, M Yasin Ashraf
The aim of the current study was to evaluate interactions among polyphenols from different plants and their effect on antioxidant potential. Different mixtures of plant extracts of Crataegus oxyacantha (C), Elettaria cardamomum (Cr), Terminalia arjuna (T) and Rauvolfia serpentina (R) were prepared and evaluated for total phenolics, flavonoid contents, and antioxidant activity. A correlation was also established between total phenolics, flavonoids and antioxidant activity. Comparative evaluation revealed that phenolics, flavonoids and antioxidant activity were found high in plant extracts mixtures than individual plants...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29039035/temporal-dynamics-of-land-use-land-cover-change-and-its-prediction-using-ca-ann-model-for-southwestern-coastal-bangladesh
#9
M Tauhid Ur Rahman, Faheemah Tabassum, Md Rasheduzzaman, Humayra Saba, Lina Sarkar, Jannatul Ferdous, Syed Zia Uddin, A Z M Zahedul Islam
Change analysis of land use and land cover (LULC) is a technique to study the environmental degradation and to control the unplanned development. Analysis of the past changing trend of LULC along with modeling future LULC provides a combined opportunity to evaluate and guide the present and future land use policy. The southwest coastal region of Bangladesh, especially Assasuni Upazila of Satkhira District, is the most vulnerable to natural disasters and has faced notable changes in its LULC due to the combined effects of natural and anthropogenic causes...
October 17, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29038698/association-of-hematological-indices-with-prediabetes-a-cross-sectional-study
#10
Amir Ziaee, Azam Ghorbani, Saied Kalbasi, Alireza Hejrati, Saba Moradi
BACKGROUND: Prediabetes is a condition that occurs when blood glucose levels are higher than normal, but not high enough to be classified as diabetes. Prediabetic people have an increased risk of developing type 2 diabetes and cardiovascular disease. Moreover Hyperglycemia has multiple effects on the hematological parameters. OBJECTIVE: To examine the association between hematological indices and anthropometric measurement, with prediabetes. METHODS: This cross-sectional study was conducted on 125 diabetics and 259 prediabetics in the 20-70 age range...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29038159/loss-of-erk1-2-in-the-retinal-pigment-epithelium-leads-to-rpe65-decrease-and-retinal-degeneration
#11
Aswin Pyakurel, Delphine Balmer, Marc K Saba-El-Leil, Caroline Kizilyaprak, Jean Daraspe, Bruno M Humbel, Laure Voisin, Yun Z Le, Johannes von Lintig, Sylvain Meloche, Raphaël Roduit
Recent work has suggested that the activity of extracellular signal-regulated kinase (ERK) 1/2 is increased in the retinal pigment epithelium (RPE) of age-related macular degeneration (ARMD) patients and therefore could be an attractive therapeutic target. Notably, ERK1/2 pathway inhibitors are used in cancer therapy, with severe and non-characterized ocular side effects. To decipher the role of ERK1/2 in RPE cells, we conditionally disrupted the Erk1 and Erk2 genes in the mouse RPE. Loss of ERK1/2 activity resulted in a significant decrease of RPE65 expression, a decrease in ocular retinoid levels concomitant with low visual function and a rapid disorganization of RPE cells, ultimately leading to retinal degeneration...
October 16, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29036123/computational-study-of-optical-force-between-two-nanodistant-plasmonic-submicrowires
#12
Masoud Rezvani Jalal, Saba Fathollahi
In this paper, the optical force between two circular plasmonic wires of submicrometer diameter (0.3 μm) with nanometer surface-to-surface distances (3-30 nm) interacting with radiation of a complex point source (λ≈0.2 μm) is numerically studied. Calculations (which are based on the Müller integral equations and the Maxwell stress tensor) show that an attractive optical force with a number of distinct peaks is created in distances 3-10 nm. However, for plasmonic-dielectric and plasmonic-reflector double-wires, the optical force has no such peaks...
July 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29033992/patient-safety-culture-in-intensive-care-units-from-the-perspective-of-nurses-a-cross-sectional-study
#13
Sedigheh Farzi, Azam Moladoost, Masoud Bahrami, Saba Farzi, Reza Etminani
BACKGROUND: One of the goals of nursing is providing safe care, prevention of injury, and health promotion of patients. Patient safety in intensive care units is threatened for various reasons. This study aimed to survey patient safety culture from the perspective of nurses in intensive care units. MATERIALS AND METHODS: This cross-sectional study was conducted in 2016. Sampling was done using the convenience method. The sample consisted of 367 nurses working in intensive care units of teaching hospitals affiliated to Isfahan University of Medical Sciences...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29030599/genome-wide-meta-analysis-associates-hla-dqa1-drb1-and-lpa-and-lifestyle-factors-with-human-longevity
#14
Peter K Joshi, Nicola Pirastu, Katherine A Kentistou, Krista Fischer, Edith Hofer, Katharina E Schraut, David W Clark, Teresa Nutile, Catriona L K Barnes, Paul R H J Timmers, Xia Shen, Ilaria Gandin, Aaron F McDaid, Thomas Folkmann Hansen, Scott D Gordon, Franco Giulianini, Thibaud S Boutin, Abdel Abdellaoui, Wei Zhao, Carolina Medina-Gomez, Traci M Bartz, Stella Trompet, Leslie A Lange, Laura Raffield, Ashley van der Spek, Tessel E Galesloot, Petroula Proitsi, Lisa R Yanek, Lawrence F Bielak, Antony Payton, Federico Murgia, Maria Pina Concas, Ginevra Biino, Salman M Tajuddin, Ilkka Seppälä, Najaf Amin, Eric Boerwinkle, Anders D Børglum, Archie Campbell, Ellen W Demerath, Ilja Demuth, Jessica D Faul, Ian Ford, Alessandro Gialluisi, Martin Gögele, MariaElisa Graff, Aroon Hingorani, Jouke-Jan Hottenga, David M Hougaard, Mikko A Hurme, M Arfan Ikram, Marja Jylhä, Diana Kuh, Lannie Ligthart, Christina M Lill, Ulman Lindenberger, Thomas Lumley, Reedik Mägi, Pedro Marques-Vidal, Sarah E Medland, Lili Milani, Reka Nagy, William E R Ollier, Patricia A Peyser, Peter P Pramstaller, Paul M Ridker, Fernando Rivadeneira, Daniela Ruggiero, Yasaman Saba, Reinhold Schmidt, Helena Schmidt, P Eline Slagboom, Blair H Smith, Jennifer A Smith, Nona Sotoodehnia, Elisabeth Steinhagen-Thiessen, Frank J A van Rooij, André L Verbeek, Sita H Vermeulen, Peter Vollenweider, Yunpeng Wang, Thomas Werge, John B Whitfield, Alan B Zonderman, Terho Lehtimäki, Michele K Evans, Mario Pirastu, Christian Fuchsberger, Lars Bertram, Neil Pendleton, Sharon L R Kardia, Marina Ciullo, Diane M Becker, Andrew Wong, Bruce M Psaty, Cornelia M van Duijn, James G Wilson, J Wouter Jukema, Lambertus Kiemeney, André G Uitterlinden, Nora Franceschini, Kari E North, David R Weir, Andres Metspalu, Dorret I Boomsma, Caroline Hayward, Daniel Chasman, Nicholas G Martin, Naveed Sattar, Harry Campbell, Tōnu Esko, Zoltán Kutalik, James F Wilson
Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#15
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29025638/identification-of-anti-cancer-potential-of-doxazocin-loading-into-chitosan-based-biodegradable-hydrogels-for-on-site-delivery-to-treat-cervical-cancer
#16
Arshad Jamal, Lubna Shahzadi, Samreen Ahtzaz, Saba Zahid, Aqif Anwar Chaudhry, Ihtesham Ur Rehman, Muhammad Yar
In this study, an effective, biocompatible and biodegradable co-polymer comprising of chitosan (CS) and polyvinyl alcohol (PVA) hydrogels, chemically crosslinked and impregnated with doxazocin, is reported. The chemical structural properties of the hydrogels were evaluated by Fourier Transform Infrared spectroscopy (FTIR) and physical properties were analysed by scanning electron microscopy (SEM). The swelling behaviour is an important parameter for drug release mechanism and was investigated to find out the solution absorption capacity of the synthesized hydrogels...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29019691/ph-induced-changes-in-the-surface-viscosity-of-unsaturated-phospholipids-monitored-using-active-interfacial-microrheology
#17
Saba Ghazvini, Ryan Alonso, Nabil Alhakamy, Prajnaparamita Dhar
Lipid membranes, a major component of cells, are subjected to significant changes in the pH depending on their location in the cell: the outer leaflet of the cell membrane is exposed to a pH of 7.4 while lipid membranes that make up late endosomes and lysosomes are exposed to a pH as low as 4.4. The purpose of this study is to evaluate how changes in the environmental pH within cells alter the fluidity of phospholipid membranes. Specifically, we studied pH induced alterations in the surface arrangement of monounsaturated lipids with zwitterionic head-groups (phosphoethanolamine (PE) and phosphocholine (PC)) that are abundant in plasma membrane, as well as anionic lipids (phosphatidylserine (PS) and phosphatidylglycerol (PG)) that are abundant in inner membranes, using a combination of techniques including surface tension vs...
October 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28993409/malt1-inhibition-is-efficacious-in-both-na%C3%A3-ve-and-ibrutinib-resistant-chronic-lymphocytic-leukemia
#18
Nakhle S Saba, Deanna H Wong, Georges Tanios, Jessica R Iyer, Patricia Lobelle-Rich, Eman L Dadashian, Delong Liu, Lorena Fontan, Erik K Flemington, Cydney M Nichols, Chingiz Underbayev, Hana Safah, Ari Melnick, Adrian Wiestner, Sarah E M Herman
The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged by the frequent emergence of resistant clones. The ibrutinib target, Bruton's tyrosine kinase (BTK), is essential for B cell receptor signaling, and most resistant cases carry mutations in BTK or PLCG2, a downstream effector target of BTK. Recent findings show that MI-2, a small molecule inhibitor of the para-caspase MALT1, is effective in preclinical models of another type of BCR pathway-dependent lymphoma...
October 9, 2017: Cancer Research
https://www.readbyqxmd.com/read/28990476/disruption-of-the-reproductive-axis-in-freshwater-fish-catla-catla-after-bisphenol-a-exposure
#19
Mehwish Faheem, Saba Khaliq, Khalid Pervaz Lone
Environmental estrogens such as bisphenol-A (BPA) cause reproductive disorders in many vertebrate species, especially fish. BPA is used extensively in the manufacture of plastic and plastic products, epoxy resins, and dental sealants. The presence of BPA in sewage and surface water raises a potential threat to aquatic populations. In the present study, we investigated the effects of BPA on ovarian histology and transcription of key genes involved in reproduction. Adult female Catla catla were exposed to graded concentrations of BPA (10, 100, 1000 µg/l) for 14 days...
October 2017: Zoological Science
https://www.readbyqxmd.com/read/28988798/differential-carbonylation-of-proteins-in-end-stage-human-fatty-and-nonfatty-nash
#20
Colin T Shearn, Laura M Saba, James R Roede, David J Orlicky, Alisabeth H Shearn, Dennis R Petersen
OBJECTIVE: In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease is oxidative stress leading to the accumulation of highly reactive electrophilic α/β unsaturated aldehydes. The objective of this study was to determine if significant differences were evident when evaluating carbonylation in human end-stage fatty nonalcoholic steatohepatitis (fNASH) compared to end-stage nonfatty NASH (nfNASH). METHODS: Using hepatic tissue obtained from healthy humans and patients diagnosed with end stage nfNASH or fNASH, overall carbonylation was assessed by immunohistochemistry (IHC) and LC-MS/MS followed by bioinformatics...
October 6, 2017: Free Radical Biology & Medicine
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