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https://www.readbyqxmd.com/read/28076656/combined-inhaled-beta-agonist-and-anticholinergic-agents-for-emergency-management-in-adults-with-asthma
#1
REVIEW
Scott W Kirkland, Christine Vandenberghe, Britt Voaklander, Taylor Nikel, Sandra Campbell, Brian H Rowe
BACKGROUND: Inhaled short-acting anticholinergics (SAAC) and short-acting beta₂-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone. OBJECTIVES: To conduct an up-to-date systematic search and meta-analysis on the effectiveness of combined inhaled therapy (SAAC + SABA agents) vs...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28074063/direct-in-vivo-evidence-for-increased-proliferation-of-cll-cells-in-lymph-nodes-compared-to-bone-marrow-and-peripheral-blood
#2
T M Herndon, S-S Chen, N S Saba, J Valdez, C Emson, M Gatmaitan, X Tian, T E Hughes, C Sun, D C Arthur, M Stetler-Stevenson, C M Yuan, C U Niemann, G E Marti, G Aue, S Soto, M Z H Farooqui, S E M Herman, N Chiorazzi, A Wiestner
Chronic Lymphocytic Leukemia (CLL) is a progressive malignancy of mature B-cells that involves the peripheral blood (PB), lymph nodes (LNs) and bone marrow (BM). While the majority of CLL cells are in a resting state, small populations of proliferating cells exist; however, the anatomical site of active cell proliferation remains to be definitively determined. Based on findings that CLL cells in LNs have increased expression of B-cell activation genes, we tested the hypothesis that the fraction of 'newly born' cells would be highest in the LNs...
January 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28073681/association-of-cytoplasmic-cxcr4-with-loss-of-epithelial-marker-and-activation-of-erk1-2-and-akt-signaling-pathways-in-non-small-cell-lung%C3%A2-cancer
#3
Nabil F Saba, Yuxiang Wang, Hongpeng Fu, Lydia Koenig, Fadlo R Khuri, Dong M Shin, Zhuo Georgia Chen
OBJECTIVES: Compelling evidence demonstrates that CXC-chemokine receptor 4 (CXCR4) is involved in tumor invasion, angiogenesis, metastasis, and resistance to chemotherapy in addition to being one of the coreceptors for T-tropic human immunodeficiency virus entry into T cells. However, it remains controversial as to how to identify functionally activated CXCR4 in tumor biopsies, which would assist in determining which patients may benefit from potential CXCR4-targeted therapy. MATERIALS AND METHODS: Immunohistochemistry (IHC) staining on archival tissues of patients with non-small-cell lung cancer (NSCLC) was used to detect a panel of biomarkers, including phospho-ERK1/2, phospho-AKT, and E-cadherin, which are relevant to downstream signaling of CXCR4 and epithelial to mesenchymal transition (EMT)...
December 22, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28073491/gray-matter-neuritic-microstructure-deficits-in-schizophrenia-and-bipolar-disorder
#4
Arash Nazeri, Benoit H Mulsant, Tarek K Rajji, Melissa L Levesque, Jon Pipitone, Laura Stefanik, Saba Shahab, Tina Roostaei, Anne L Wheeler, Sofia Chavez, Aristotle N Voineskos
BACKGROUND: Postmortem studies have demonstrated considerable dendritic pathologies among persons with schizophrenia and to some extent among those with bipolar I disorder. Modeling gray matter (GM) microstructural properties is now possible with a recently proposed diffusion-weighted magnetic resonance imaging modeling technique: neurite orientation dispersion and density imaging. This technique may bridge the gap between neuroimaging and histopathological findings. METHODS: We performed an extended series of multishell diffusion-weighted imaging and other structural imaging series using 3T magnetic resonance imaging...
December 8, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28069068/the-sygma-programme-of-phase-3-trials-to-evaluate-the-efficacy-and-safety-of-budesonide-formoterol-given-as-needed-in-mild-asthma-study-protocols-for-two-randomised-controlled-trials
#5
Paul M O'Byrne, J Mark FitzGerald, Nanshan Zhong, Eric Bateman, Peter J Barnes, Christina Keen, Gun Almqvist, Kristine Pemberton, Carin Jorup, Stefan Ivanov, Helen K Reddel
BACKGROUND: In many patients with mild asthma, the low frequency of symptoms and the episodic nature of exacerbations make adherence to regular maintenance treatment difficult. This often leads to over-reliance on short-acting β2-agonist (SABA) reliever medication and under-treatment of the underlying inflammation, with poor control of asthma symptoms and increased risk of exacerbations. The use of budesonide/formoterol 'as needed' in response to symptoms may represent an alternative treatment option for patients with mild asthma...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28066862/impact-of-race-on-outcome-of-patients-undergoing-rhythm-control-of-atrial-fibrillation
#6
Asad F Durrani, Siva Soma, Andrew D Althouse, George Leef, Dingxin Qin, Samir Saba
Racial disparities between African American (AA) and White patients have been documented in cardiovascular disease. We investigated whether these disparities exist in patients undergoing rhythm control for atrial fibrillation (AF). 5873 AF patients (241 AA) were followed to the endpoint of death, stroke, or AF recurrence. Invasive procedures for AF rhythm control were examined in both racial groups. Over a mean follow-up time of 40 months, AA patients had a higher adjusted risk of death [HR 1.39, 95% CI 1...
January 9, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28065707/craniofacial-characteristics-in-the-sagittal-dimension-a-cephalometric-study-in-lebanese-young-adults
#7
Antoine Daraze, Myriam Delatte, Sami Bou Saba, Zeina Majzoub
OBJECTIVES: The purpose of this study was to assess the sagittal cephalometric characteristics of young adult Lebanese individuals and assess gender-related differences. MATERIALS AND METHODS: Conventional lateral cephalograms were obtained from 117 subjects. Eight linear/angular measurements combining sagittal parameters selected form McNamara and Steiner analyses were recorded. Paired t-test was applied to evaluate differences between genders and skeletal classes...
January 5, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28065706/caract%C3%A3-ristiques-craniofaciales-dans-le-sens-sagittal%C3%A2-%C3%A3-tude-c%C3%A3-phalom%C3%A3-trique-chez-de-jeunes-adultes-libanais
#8
Antoine Daraze, Myriam Delatte, Sami Bou Saba, Zeina Majzoub
No abstract text is available yet for this article.
January 5, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28059707/ct-accuracy-of-extrinsic-tongue-muscle-invasion-in-oral-cavity-cancer
#9
J C Junn, K L Baugnon, E A Lacayo, P A Hudgins, M R Patel, K R Magliocca, A S Corey, M El-Deiry, J T Wadsworth, J J Beitler, N F Saba, Y Liu, A H Aiken
BACKGROUND AND PURPOSE: Extrinsic tongue muscle invasion in oral cavity cancer upstages the primary tumor to a T4a. Despite this American Joint Committee on Cancer staging criterion, no studies have investigated the accuracy or prognostic importance of radiologic extrinsic tongue muscle invasion, the feasibility of standardizing extrinsic tongue muscle invasion reporting, or the degree of agreement across different disciplines: radiology, surgery, and pathology. The purpose of this study was to assess the agreement among radiology, surgery, and pathology for extrinsic tongue muscle invasion and to determine the imaging features most predictive of extrinsic tongue muscle invasion with surgical/pathologic confirmation...
November 10, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28059217/selective-excitation-of-higher-order-modes-in-etched-gelatin-coated-few-mode-fiber-and-demonstration-of-high-relative-humidity-measurement
#10
Saba N Khan, Partha Roy Chaudhuri
We report here our experimental studies on efficient excitation of higher-order modes in a few-mode fiber realized through selective chemical etching of single-mode fiber, depositing a dynamic refractive index profile coating (gelatin) and designing a well-performing high relative humidity (RH) (73%-99% RH) sensor with sensitivity as high as ∼1.2  dBm/% RH and fast response (∼125  ms). The design relies on fixing quasi-adiabatic transition of the single-mode-few-mode-single-mode configuration to launch light at angles corresponding to desired higher-order modes, pushing more power into the coating...
January 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/28055272/rs12603332-is-associated-with-male-asthma-patients-specifically-in-urban-areas-of-lahore-pakistan
#11
Muhammad Farooq Sabar, Mariam Shahid, Iqbal Bano, Muhammad Usman Ghani, Muhammad Akram, Farheena Iqbal, Samra Kousar, Zafar Iqbal, Saba Altaf, Tayyab Husnain
OBJECTIVE: rs12603332, an important regulatory site variant, is known to alter the regulatory motif E2A that is involved in maturation of B-lymphocytes. The study was designed to check whether different environmental exposures alter its risk allele association with asthma or not. METHODS: 200 Physician diagnosed asthma patients and 108 healthy individuals were enrolled from hospitals of Lahore. After quantitation of DNA extracted from their peripheral blood samples, amplification of genomic region with rs12603332 was performed followed by single base extension...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28053517/the-use-of-multiple-respiratory-inhalers-requiring-different-inhalation-techniques-has-an-adverse-effect-on-copd-outcomes
#12
Sinthia Bosnic-Anticevich, Henry Chrystyn, Richard W Costello, Myrna B Dolovich, Monica J Fletcher, Federico Lavorini, Roberto Rodríguez-Roisin, Dermot Ryan, Simon Wan Yau Ming, David B Price
BACKGROUND: Patients with COPD may be prescribed multiple inhalers as part of their treatment regimen, which require different inhalation techniques. Previous literature has shown that the effectiveness of inhaled treatment can be adversely affected by incorrect inhaler technique. Prescribing a range of device types could worsen this problem, leading to poorer outcomes in COPD patients, but the impact is not yet known. AIMS: To compare clinical outcomes of COPD patients who use devices requiring similar inhalation technique with those who use devices with mixed techniques...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28052881/headache-outcomes-in-children-undergoing-foramen-magnum-decompression-for-chiari-i-malformation
#13
Saba Raza-Knight, Kshitij Mankad, Prab Prabhakar, Dominic Thompson
OBJECTIVE: A common symptom of Chiari I malformation (CIM) is headache, which is diagnosed using non-validated criteria from the International Headache Society (IHS). CIM-associated headaches should resolve following neurosurgical treatment of the malformation by foramen magnum decompression (FMD). We aimed to validate the IHS criteria and determine (1) the efficacy of FMD in treating headache and (2) whether duraplasty confers an advantage over simple bony decompression in the treatment of this symptom...
January 4, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28049270/identifying-acceptability-and-price-points-for-purchasing-micronutrient-powders-for-children-2-to-5-years-old-in-nepal
#14
Rajni Gunnala, Cria G Perrine, Giriraj Subedi, Saba Mebrahtu, Pradiumna Dahal, Maria Elena Jefferds
BACKGROUND AND OBJECTIVE: Little is known about purchasing micronutrient powders (MNP) for children 2-5 years. We describe acceptability for purchasing and price points for MNP for children 2-5 years among caregivers living in districts where free MNP are distributed for children 6-23 months. METHODS AND STUDY DESIGN: Crosssectional surveys conducted 3 months after MNP program implementation in 2 districts; 15 months after implementation in 2 different districts...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28043773/pulmonary-sarcomatoid-carcinoma-an-analysis-of-the-national-cancer-data-base
#15
Conor E Steuer, Madhusmita Behera, Yuan Liu, Chao Fu, Theresa W Gillespie, Nabil F Saba, Dong M Shin, Rathi N Pillai, Suchita Pakkala, Taofeek K Owonikoko, Fadlo R Khuri, Suresh S Ramalingam
INTRODUCTION: Pulmonary sarcomatoid carcinoma (PSC) is a grouping of 5 rare non-small-cell lung cancer (NSCLC) subtypes. We studied the clinical characteristics and outcomes of PSC utilizing the National Cancer Data Base (NCDB), an oncology outcomes database. METHODS: The NCDB lung cancer database was queried from 1998 to 2011 for PSC using ICD-O-3 codes. Data were extracted for patient demographics, tumor pathology, treatment, and outcomes. Overall survival (OS) data were available for patients diagnosed from 1998 to 2006 and comorbidity data from 2003 to 2011...
December 7, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#16
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28031213/relationship-between-distance-and-change-in-surface-ecg-morphology-during-pacemapping-as-a-guide-to-ablation-of-ventricular-arrhythmias-implications-for-the-spatial-resolution-of-pacemapping
#17
Anthony Li, Joseph Samuel Davis, Jeremiah Wierwille, Keith Herold, Dennis Morgan, Elijah Behr, Stephen Shorofsky, Magdi Saba
BACKGROUND: Pacemapping is used to localize the exit site of ventricular arrhythmia. Although the relationship between distance and change in QRS morphology is its basis, this relationship has not been systematically quantified. METHODS AND RESULTS: Patients (n=68) undergoing ventricular arrhythmia ablation between March 2012 and July 2013 were recruited. Pacemapping was targeted to areas of voltage >0.5 mV. Linear mixed-effects models were constructed of distance against morphology difference measured by the root mean square error sum across all 12 ECG leads (E12)...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28027821/entrococcus-faecalis-elimination-in-root-canals-using-silver-nanoparticles-photodynamic-therapy-diode-laser-or-laser-activated-nanoparticles-an-in%C3%A2-vitro-study
#18
Farzaneh Afkhami, Saba Akbari, Nasim Chiniforush
INTRODUCTION: The aim of this study was to compare the efficacy of silver nanoparticles (AgNPs), an 810-nm diode laser (DL), conventional photodynamic therapy (PDT) with the use of indocyanine green (ICG) photosensitizer, and modified PDT with the use of AgNPs for the disinfection of root canals inoculated with Enterococcus faecalis. METHODS: The root canals of 65 extracted human single-rooted teeth were prepared, and E. faecalis was incubated in the root canals for 4 weeks...
December 24, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28017375/genome-wide-trans-ethnic-meta-analysis-identifies-seven-genetic-loci-influencing-erythrocyte-traits-and-a-role-for-rbpms-in-erythropoiesis
#19
Frank J A van Rooij, Rehan Qayyum, Albert V Smith, Yi Zhou, Stella Trompet, Toshiko Tanaka, Margaux F Keller, Li-Ching Chang, Helena Schmidt, Min-Lee Yang, Ming-Huei Chen, James Hayes, Andrew D Johnson, Lisa R Yanek, Christian Mueller, Leslie Lange, James S Floyd, Mohsen Ghanbari, Alan B Zonderman, J Wouter Jukema, Albert Hofman, Cornelia M van Duijn, Karl C Desch, Yasaman Saba, Ayse B Ozel, Beverly M Snively, Jer-Yuarn Wu, Reinhold Schmidt, Myriam Fornage, Robert J Klein, Caroline S Fox, Koichi Matsuda, Naoyuki Kamatani, Philipp S Wild, David J Stott, Ian Ford, P Eline Slagboom, Jaden Yang, Audrey Y Chu, Amy J Lambert, André G Uitterlinden, Oscar H Franco, Edith Hofer, David Ginsburg, Bella Hu, Brendan Keating, Ursula M Schick, Jennifer A Brody, Jun Z Li, Zhao Chen, Tanja Zeller, Jack M Guralnik, Daniel I Chasman, Luanne L Peters, Michiaki Kubo, Diane M Becker, Jin Li, Gudny Eiriksdottir, Jerome I Rotter, Daniel Levy, Vera Grossmann, Kushang V Patel, Chien-Hsiun Chen, Paul M Ridker, Hua Tang, Lenore J Launer, Kenneth M Rice, Ruifang Li-Gao, Luigi Ferrucci, Michelle K Evans, Avik Choudhuri, Eirini Trompouki, Brian J Abraham, Song Yang, Atsushi Takahashi, Yoichiro Kamatani, Charles Kooperberg, Tamara B Harris, Sun Ha Jee, Josef Coresh, Fuu-Jen Tsai, Dan L Longo, Yuan-Tsong Chen, Janine F Felix, Qiong Yang, Bruce M Psaty, Eric Boerwinkle, Lewis C Becker, Dennis O Mook-Kanamori, James G Wilson, Vilmundur Gudnason, Christopher J O'Donnell, Abbas Dehghan, L Adrienne Cupples, Michael A Nalls, Andrew P Morris, Yukinori Okada, Alexander P Reiner, Leonard I Zon, Santhi K Ganesh
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associated with mean corpuscular hemoglobin and mean corpuscular volume...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28013446/evaluation-of-the-validity-of-osteoporosis-and-fracture-risk-assessment-tools-iof-one-minute-test-score-and-frax-in-postmenopausal-palestinian-women
#20
Akram Kharroubi, Elias Saba, Ibrahim Ghannam, Hisham Darwish
: The need for simple self-assessment tools is necessary to predict women at high risk for developing osteoporosis. In this study, tools like the IOF One Minute Test, Fracture Risk Assessment Tool (FRAX), and Simple Calculated Osteoporosis Risk Estimation (SCORE) were found to be valid for Palestinian women. The threshold for predicting women at risk for each tool was estimated. PURPOSE: The purpose of this study is to evaluate the validity of the updated IOF (International Osteoporosis Foundation) One Minute Osteoporosis Risk Assessment Test, FRAX, SCORE as well as age alone to detect the risk of developing osteoporosis in postmenopausal Palestinian women...
December 2017: Archives of Osteoporosis
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