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https://www.readbyqxmd.com/read/28209712/mycobacterium-tuberculosis-esxl-inhibit-mhc-ii-expression-by-promoting-hypermethylation-in-class-ii-transactivator-loci-in-macrophages
#1
Srabasti Sengupta, Saba Naz, Ishani Das, Abdul Ahad, Avinash Padhi, Sumanta Naik, Geetanjali Ganguli, Kaliprasad Patnaik, Sunil Kumar Raghav, Vinay Nandicoori, Avinash Sonawane
Mycobacterium tuberculosis (Mtb) is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and MHC-II down-regulation is not well studied. Mtb 6-kDa early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic determinant. Mtb genome encodes 23 such ESAT-6 family proteins. We herein report that Mtb and M...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28202459/il-4-cxcl12-loop-is-a-key-regulator-of-lymphoid-stroma-function-in-follicular-lymphoma
#2
Shubham Pandey, Frédéric Mourcin, Tony Marchand, Saba Nayar, Marion Guirriec, Céline Pangault, Céline Monvoisin, Patricia Amé-Thomas, Fabien Guilloton, Joelle Dulong, Mark Coles, Thierry Fest, Anja Mottok, Francesca Barone, Karin Tarte
Follicular lymphoma (FL) is the most frequent indolent lymphoma and is characterized by the accumulation of germinal center-derived malignant B cells engaged in a bidirectional crosstalk with their supportive microenvironment in invaded lymph nodes (LN) and bone marrow (BM). T follicular helper cells (TFH) and infiltrating stromal cells have been shown to favor FL B-cell growth but the mechanisms of their protumoral effect and how LN/BM microenvironment is converted into a lymphoma-permissive cell niche remain poorly understood...
February 15, 2017: Blood
https://www.readbyqxmd.com/read/28199833/fgf21-administration-suppresses-retinal-and-choroidal-neovascularization-in-mice
#3
Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S Meng, Samuel B Burnim, Nicholas J Saba, Thomas W Fredrick, Peyton C Morss, Ann Hellstrom, Saswata Talukdar, Lois E H Smith
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Using a mouse model of hypoxia-driven retinal neovascularization, we find that fibroblast growth factor 21 (FGF21) administration suppresses, and FGF21 deficiency worsens, retinal neovessel growth. The protective effect of FGF21 against neovessel growth was abolished in adiponectin (APN)-deficient mice. FGF21 administration also decreased neovascular lesions in two models of neovascular age-related macular degeneration: very-low-density lipoprotein-receptor-deficient mice with retinal angiomatous proliferation and laser-induced choroidal neovascularization...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28199045/nasal-juvenile-angiofibroma-current-perspectives-with-emphasis-on-management
#4
Fernando López, Asterios Triantafyllou, Carl H Snyderman, Jennifer L Hunt, Carlos Suárez, Valerie J Lund, Primož Strojan, Nabil F Saba, Iain J Nixon, Kenneth O Devaney, Isam Alobid, Manuel Bernal-Sprekelsen, Ehab Y Hanna, Alessandra Rinaldo, Alfio Ferlito
Juvenile angiofibroma is an uncommon, benign, locally aggressive vascular tumor. It is found almost exclusively in young men. Common presenting symptoms include nasal obstruction and epistaxis. More advanced tumors may present with facial swelling and visual or neurological disturbances. The evaluation of patients with juvenile angiofibroma relies on diagnostic imaging. Preoperative biopsy is not recommended. The mainstay of treatment is resection combined with preoperative embolization. Endoscopic surgery is the approach of choice in early stages, whereas, in advanced stages, open or endoscopic approaches are feasible in expert hands...
February 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/28192709/tetrazolylmethyl-quinolines-design-docking-studies-synthesis-anticancer-and-antifungal-analyses
#5
Saba Kauser J Shaikh, Ravindra R Kamble, Shilpa M Somagond, H C Devarajegowda, Sheshagiri R Dixit, Shrinivas D Joshi
A new series of 2,5 and 1,5-regioisomers of the tetrazolyl group viz., 3-[(5-benzyl/benzylthio-2H-tetrazol-2-yl) methyl]-2-chloro-6-substituted quinoline 6h-q and 3-[(5-benzyl/benzylthio-1H-tetrazol-1-yl) methyl]-2-chloro-6-substituted quinolines 7h-q were synthesized. Docking studies of all these compounds with DNA as target using PDB: 1AU5 and 453D revealed that the compounds 6h and 6i act as covalent cross linker on the DNA helix of the former and intercalate the latter both with higher C score values. Another set of docking studies in the active pocket of dihydrofolate reductase and N-myristoyl transferase as targets to assess antifungal activity revealed that compounds 6k, 6l, 6p and 7q (with bromo and fluro substituents) showcases different binding modes and hydrogen bonding...
February 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28188694/tracing-the-footprints-a-case-of-chronic-meningitis-with-unusual-mononuclear-cells-in-the-cerebrospinal-fluid
#6
Andres M Acosta, James W Antoon, Megan Kempe, Saba Ahmad, John Groth, Tibor Valyi-Nagy, Odile David, Robert J Cabay
No abstract text is available yet for this article.
February 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28188242/diagnosis-of-endocrine-disease-steroid-hormone-analysis-in-diagnosis-and-treatment-of-dsd-position-paper-of-eu-cost-action-bm-1303-dsdnet
#7
Alexandra Kulle, Nils Krone, Paul-Martin Holterhus, Gerhard Schuler, Ronda Greaves, Anders Juul, Yolanda de Rijke, Michaela Hartmann, Alessandro Saba, Olaf Hiort, Stefan Wudy
Disorders or differences in sex development (DSD) comprise a heterogeneous group of conditions with an atypical sex development. For optimal diagnosis highly specialized laboratory analyses are required across European countries. Working group 3 of EU COST (European Cooperation in Science and Technology) Action BM 1303 "DSDnet" "Harmonisation of Laboratory Assessment" has developed recommendations on laboratory assessment for DSD regarding the use of technologies and analytes to be investigated. This position paper on steroid hormone analysis in diagnosis and treatment of DSD was compiled by a group of specialists in DSD and/or hormonal analysis, either from participating European Countries or international partner countries...
February 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28181034/hiv-1-genetic-diversity-and-transmitted-drug-resistance-frequency-among-iranian-treatment-naive-sexually-infected-individuals
#8
Rouhollah Vahabpour, Farah Bokharaei-Salim, Saeed Kalantari, Saba Garshasbi, Seyed Hamidreza Monavari, Maryam Esghaei, Arash Memarnejadian, Atousa Fakhim, Hossein Keyvani
In recent years, the patterns of human immunodeficiency virus 1 (HIV-1) transmission in Iran have been changing gradually from drug injection to unprotected sexual contact. This study sought to investigate the phylogenetic trends and characteristics of transmitted drug resistance (TDR) mutations of HIV-1 in a population that is mainly infected through homo/heterosexual contacts. Sixty newly diagnosed antiretroviral-naive individuals with HIV infection living in Tehran were recruited to this survey, and among them, 42 subjects were established to be infected through sexual intercourse...
February 8, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28174086/chitosan-coated-tungsten-trioxide-nanoparticles-as-a-contrast-agent-for-x-ray-computed-tomography
#9
Mehdi Firouzi, Reza Poursalehi, H Delavari, Fakhredin Saba, Mohammad A Oghabian
Recent advances have shown that inorganic nanoparticles (NPs) based on heavy elements are highly appropriate for X-ray computed tomography (CT). In this contribution, tungsten trioxide NPs are prepared by the electrical arc discharge (EAD) method in DI water. The effect of chitosan (CTS) and glutaraldehyde (GTA) as coating and cross-linking agent, respectively, on the hydrodynamic size and zeta potential of prepared tungsten trioxide NPs is investigated. It is found that zeta potential increases by increasing the amounts of CTS...
February 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28165823/nanocarriers-as-treatment-modalities-for-hypertension
#10
Tausif Alam, Saba Khan, Bharti Gaba, Md Faheem Haider, Sanjula Baboota, Javed Ali
Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart failure, and peripheral artery disease. Though numerous drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of hypertension but they face substantial challenges regarding their bioavailability, dosing and associated adverse effects which greatly limit their therapeutic efficacies...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165339/mutations-in-sphingosine-1-phosphase-lyase-cause-nephrosis-with-ichthyosis-and-adrenal-insufficiency
#11
Svjetlana Lovric, Sara Goncalves, Heon Yung Gee, Babak Oskouian, Honnappa Srinivas, Won-Il Choi, Shirlee Shril, Shazia Ashraf, Weizhen Tan, Jia Rao, Merlin Airik, David Schapiro, Daniela A Braun, Carolin E Sadowski, Eugen Widmeier, Tilman Jobst-Schwan, Johanna Magdalena Schmidt, Vladimir Girik, Guido Capitani, Jung H Suh, Noëlle Lachaussée, Christelle Arrondel, Julie Patat, Olivier Gribouval, Monica Furlano, Olivia Boyer, Alain Schmitt, Vincent Vuiblet, Seema Hashmi, Rainer Wilcken, Francois P Bernier, A Micheil Innes, Jillian S Parboosingh, Ryan E Lamont, Julian P Midgley, Nicola Wright, Jacek Majewski, Martin Zenker, Franz Schaefer, Navina Kuss, Johann Greil, Thomas Giese, Klaus Schwarz, Vilain Catheline, Denny Schanze, Ingolf Franke, Yves Sznajer, Anne S Truant, Brigitte Adams, Julie Désir, Ronald Biemann, York Pei, Elisabet Ars, Nuria Lloberas, Alvaro Madrid, Vikas R Dharnidharka, Anne M Connolly, Marcia C Willing, Megan A Cooper, Richard P Lifton, Matias Simons, Howard Riezman, Corinne Antignac, Julie D Saba, Friedhelm Hildebrandt
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However, in many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequencing to identify recessive causes of SRNS. In 7 families with SRNS and facultative ichthyosis, adrenal insufficiency, immunodeficiency, and neurological defects, we identified 9 different recessive mutations in SGPL1, which encodes sphingosine-1-phosphate (S1P) lyase...
February 6, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28158122/high-resolution-wavelet-fractal-compressed-optical-coherence-tomography-images
#12
Mekhalfa Faiza, Saba Adabi, Berkani Daoud, Mohammad R N Avanaki
Three-dimensional (3D) optical coherence tomography (OCT) images could assist specialists in the diagnosis of a disease in a tissue by providing morphological information from it. Since the size of such images is usually extremely large, an appropriate image compression method can help in the storage and transmission of these images. Fractal image compression provides very high compression ratios, and discrete wavelet transform (DWT) retains frequency and spatial information in the signal. In order to combine these two techniques, fractal coding has to be performed in the wavelet domain...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28156053/urothelial-cell-expansion-and-differentiation-are-improved-by-exposure-to-hypoxia
#13
Stéphane Chabaud, Ingrid Saba, Clément Baratange, Brice Boiroux, Maude Leclerc, Alexandre Rousseau, Sara Bouhout, Stéphane Bolduc
Cells obtained from a patient's biopsy have to be expanded after extraction to produce autologous tissues, but standard cell culture conditions often limit their growth or lifespan and could induce early and inadequate cell differentiation. Moreover, it has previously been reported that the air-liquid interface, that induces maturation of the urothelium, stimulated inadequate differentiation associated with aberrant keratin-14 expression. The aim of this study was to test the benefits of hypoxia during expansion of urothelial cells and maturation of the bladder epithelium in the context of tissue engineering...
February 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28154473/neuropeptides-and-microglial-activation-in-inflammation-pain-and-neurodegenerative-diseases
#14
REVIEW
Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Juan Turati, Carla Caruso, Teresa N Scimonelli, Mercedes Lasaga
Microglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response. Alterations to this delicate process may lead to tissue damage, neuroinflammation, and neurodegeneration. Chronic pain, such as inflammatory or neuropathic pain, is accompanied by neuroimmune activation, and the role of glial cells in the initiation and maintenance of chronic pain has been the subject of increasing research over the last two decades...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28147458/age-of-sexual-debut-and-physical-dating-violence-victimization-sex-differences-among-us-high-school-students
#15
Timothy O Ihongbe, Susan Cha, Saba W Masho
BACKGROUND: Research has shown that early age of sexual debut is associated with physical dating violence (PDV), but sex-specific associations are sparse. We estimated the prevalence of PDV victimization in high school students who have initiated sexual intercourse and examined sex-specific association between age of sexual debut and PDV victimization. METHODS: Data on 8637 students in grades 9 through 12 who had initiated sex was obtained from the 2009-2011 national Youth Risk Behavior Survey...
March 2017: Journal of School Health
https://www.readbyqxmd.com/read/28145022/gray-matter-heritability-in-family-based-and-population-based-studies-using-voxel-based-morphometry
#16
Sven J van der Lee, Gennady V Roshchupkin, Hieab H H Adams, Helena Schmidt, Edith Hofer, Yasaman Saba, Reinhold Schmidt, Albert Hofman, Najaf Amin, Cornelia M van Duijn, Meike W Vernooij, M Arfan Ikram, Wiro J Niessen
BACKGROUND: The combination of genetics and imaging has improved their understanding of the brain through studies of aggregate measures obtained from high-resolution structural imaging. Voxel-wise analyses have the potential to provide more detailed information of genetic influences on the brain. Here they report a large-scale study of the heritability of gray matter at voxel resolution (1 × 1 × 1 mm). METHODS: Validated voxel-based morphometry (VBM) protocols were applied to process magnetic resonance imaging data of 3,239 unrelated subjects from a population-based study and 491 subjects from two family-based studies...
February 1, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28138193/haemoperitoneum-due-to-ruptured-ovarian-cyst-in-a-13-year-old-girl-with-factor-v-deficiency-a-case-report
#17
Saba Laila Aslam, Muhammed Fareeduddin
Factor V deficiency is a rare autosomal recessive coagulation disorder. We are reporting a case of a 13 year old girl with factor V deficiency presenting as life threatening haemoperitoneum, following bleeding from ruptured ovarian cyst. Prolonged Prothrombin Time, Activated Partial Thromboplastin Time and a normal platelet count pointed towards a disorder of coagulation. Mixing study with factor V deficient plasma and coagulation factor assay revealed markedly reduced plasma factor V clotting activity.
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28138192/a-rare-cause-of-recurrent-chest-infection-in-children-bronchopulmonary-sequestration
#18
Shabbir Hussain, Shoaib Ahmed, Syed Awais Ul Hassan Shah, Saba Haider Tarar
Bronchopulmonary sequestration is one of the rare thoracic congenital anomalies. We report the case of a 6 year old boy with history of recurrent episodes of chest infection and breathing difficulty. This time admitted with fever and cough. Investigations revelaed neutrophilic leucocytosis, raised C-reactive protein and a retrocardiac opacity on chest radiographs. Contrast enhanced Computed Topography(CT scan) revealed a large, well defined, left lower lobe multi-loculated cystic mass with a vessel arising from the descending aorta supplying sequestrated lung portion...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28124613/harmaline-and-its-derivatives-against-the-infectious-multi-drug-resistant-escherichia-coli
#19
Hina Siddiqui, Sehar Tasneem, Saba Farooq, Amtul Sami, Atta-Ur-Rahman, Muhammad Iqbal Choudhary
Background Multidrug resistance (MDR) is a major challenge in the treatment of infectious diseases. The MDR in urinary tract infection causing bacteria, such as Escherichia coli, has made treatment of UTI very difficult. Objective The aims of the current study were to synthesize a library of harmaline derivatives, and to evaluate their activity against various strains of multi-drug resistance (MDR) E. coli. Method Harmaline derivatives were synthesized by the reaction of harmaline (1) with various acid halides and anhydrides...
January 25, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28124221/serum-25-hydroxyvitamin-d-and-bone-turnover-markers-in-palestinian-postmenopausal-osteoporosis-and-normal-women
#20
Akram Kharroubi, Elias Saba, Riham Smoom, Khaldoun Bader, Hisham Darwish
: This study evaluated the association of vitamin D and bone markers with the development osteoporosis in Palestinian postmenopausal women. Even though vitamin D deficiency was very high for the recruited subjects, it was not associated with osteoporosis except for bones of the hip. Age and obesity were the strongest determining factors of the disease. PURPOSE: The purpose of this study was to investigate the association of bone mineral density (BMD) with serum vitamin D levels, parathyroid hormone (PTH), calcium, obesity, and bone turnover markers in Palestinian postmenopausal women...
December 2017: Archives of Osteoporosis
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