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https://www.readbyqxmd.com/read/29243330/direct-metal-free-c-sp2-h-chalcogenation-of-indoles-and-imidazopyridines-with-dichalcogenides-catalysed-by-kio3
#1
Jamal Rafique, Sumbal Saba, Marcelo S Franco, Luana Bettanin, Alex R Schneider, Lais T Silva, Antonio Luiz Braga
Herein, we report a greener protocol for the synthesis of 3-Se/S-indoles and imidazo[1,2-a]pyridines through direct C(sp2)-H bond chalcogenation of heteroarenes with half molar equiv. of different dichalcogenides, using KIO3 as a non-toxic, easily handleable catalyst and stoichiometric amount of glycerol. The reaction features are high yields, based on atom economy, ease to gram scale, metal- and solvent-free approach as well as applicable to different types of N-heteroarenes.
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29241185/treatment-step-1-for-asthma-should-not-be-left-blank-and-saba-only-might-not-be-a-treatment-step-1-option-for-asthma
#2
Luis Javier Nannini, Nadia S Neumayer
No abstract text is available yet for this article.
December 14, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29236524/the-impact-of-the-professional-qualifications-of-the-prenatal-care-provider-on-breastfeeding-duration
#3
Jordyn T Wallenborn, Juan Lu, Robert A Perera, David C Wheeler, Saba W Masho
BACKGROUND: A prenatal commitment to breastfeed is a strong predictor for breastfeeding success. Prenatal care providers have the opportunity to educate and promote breastfeeding. However, differences in education and training between healthcare providers such as physicians and midwives may result in differing breastfeeding outcomes. This study explores whether breastfeeding initiation and duration differ by prenatal care provider. MATERIALS AND METHODS: Longitudinal data from the Infant Feeding Practices Survey II were analyzed (N = 2,832 women)...
December 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29232884/practicing-dentists-self-efficacy-and-associated-factors-in-managing-the-treatment-of-adults-with-mental-and-physical-disabilities-an-exploratory-cross-sectional-study-in-riyadh-saudi-arabia
#4
Sakher AlQahtani, Ebtissam Zakaria Murshid, Hani Talal Fadel, Saba Kassim
Background: Provision of oral healthcare to adults with mental and physical disabilities (AMPD) remains a challenging area across various healthcare systems. The present study aimed to assess self-reported efficacy and investigate factors associated with self-efficacy in the management of AMPD among practicing dentists in Saudi Arabia. Methods: A pilot-tested, self-administered questionnaire was distributed to a convenience sample of 1000 dentists. Descriptive and inferential analyses were performed on the collected responses...
December 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29229727/high-salt-conditions-alter-transcription-of-helicobacter-pylori-genes-encoding-outer-membrane-proteins
#5
John T Loh, Amber C Beckett, Matthew B Scholz, Timothy L Cover
Helicobacter pylori infection and high dietary salt intake are risk factors for the development of gastric adenocarcinoma. One possible mechanism by which a high salt diet could influence gastric cancer risk is by modulating H. pylori gene expression. In this study, we utilized RNA-seq methodology to compare the transcriptional profiles of H. pylori grown in media containing different concentrations of sodium chloride. We identified 118 differentially expressed genes (65 upregulated and 53 downregulated in response to high salt conditions), including multiple members of 14 operons...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29226149/role-of-p-glycoprotein-inhibitors-in-the-bioavailability-enhancement-of-solid-dispersion-of-darunavir
#6
Saleha Rehman, Bushra Nabi, Mohammad Fazil, Saba Khan, Naimat Kalim Bari, Romi Singh, Shavej Ahmad, Varinder Kumar, Sanjula Baboota, Javed Ali
Objective: The aim of the present study was to improve bioavailability of an important antiretroviral drug, Darunavir (DRV), which has low water solubility and poor intestinal absorption through solid dispersion (SD) approach incorporating polymer with P-glycoprotein inhibitory potential. Methods: A statistical approach where design of experiment (DoE) was used to prepare SD of DRV with incorporation of P-glycoprotein inhibitors. Using DoE, different methods of preparation, like melt, solvent evaporation, and spray drying method, utilizing carriers like Kolliphor TPGS and Soluplus were evaluated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225189/luteolin-attenuates-airway-inflammation-by-inducing-the-transition-of-cd4-cd25-to-cd4-cd25-regulatory-t-cells
#7
Seung-Hyung Kim, Evelyn Saba, Bok-Kyu Kim, Won-Kyung Yang, Yang-Chun Park, Han Jae Shin, Chang Kyun Han, Young Cheol Lee, Man Hee Rhee
Regulatory T cells (Th2) play an important role in autoimmunity and have been shown to exert anti-inflammatory effects in allergic asthma. Mouse model of airway inflammation was used to examine the suppressive activity of luteolin-induced CD4+CD25+ regulatory T cells (Tregs) in vivo. In this study, BALB/c mice were sensitized with ovalbumin antigen (OVA) by aerosol challenge. Then, various biological processes were examined, including airway eosinophilia; mucus hypersecretion; elevation of OVA-specific IgE, expression of Th2 cytokines and chemokine levels; expression of eotaxin 2 and CCR3; and airway hyper responsiveness (AHR)...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223069/neuropsychological-and-clinical-heterogeneity-of-cognitive-impairment-in-patients-with-multiple-system-atrophy
#8
Lorena Broseghini Barcelos, Flávia Saad, Carla Giacominelli, Roberta Arb Saba, Patrícia Maria de Carvalho Aguiar, Sonia Maria Azevedo Silva, Vanderci Borges, Paulo Henrique Ferreira Bertolucci, Henrique Ballalai Ferraz
OBJECTIVE: We evaluated neuropsychological tests to compare cognitive impairment between two types of multiple system atrophy: predominant parkinsonism (MSA-P) and predominant cerebellar ataxia (MSA-C). PATIENTS AND METHODS: This cross-sectional study included 14 patients diagnosed with MSA: four with MSA-C and ten with MSA-P. Presence of motor symptoms was determined by using the Unified Rating MSA Scale (URMSAS). Non-motor symptoms were evaluated by the Short Form Health Survey (SF-36), Scales for Outcomes in Parkinson's disease Autonomic (SCOPA-AUT), Hospital Anxiety and Depression Scale (HADS), and Beck Depression Inventory (BDI)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29219031/the-role-of-community-pharmacists-in-the-identification-and-ongoing-management-of-women-at-risk-for-perinatal-depression-a-qualitative-study
#9
Sabrine Elkhodr, Maya Saba, Claire O'Reilly, Bandana Saini
BACKGROUND: While pharmacists are among the most accessible primary health professionals within a mother's healthcare team to identify potential cases of perinatal depression (PND), very little in the literature suggests that this role has been explored. AIM: The aim of this study was to explore community pharmacists' perspectives on their potential roles in perinatal mental health promotion (recognition and health education) and the factors affecting these roles...
December 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29218604/author-correction-to-extreme-learning-machine-framework-for-risk-stratification-of-fatty-liver-disease-using-ultrasound-tissue-characterization
#10
Venkatanareshbabu Kuppili, Mainak Biswas, Aswini Sreekumar, Harman S Suri, Luca Saba, Damodar Reddy Edla, Rui Tato Marinho, J Miguel Sanches, Jasjit S Suri
The original version of this article unfortunately contained a mistake. The family name of Rui Tato Marinho was incorrectly spelled as Marinhoe.
December 7, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29216852/access-to-affordable-medicines-and-diagnostic-tests-for-asthma-and-copd-in-sub-saharan-africa-the-ugandan-perspective
#11
Davis Kibirige, Leaticia Kampiire, David Atuhe, Raymond Mwebaze, Winceslaus Katagira, Winters Muttamba, Rebecca Nantanda, William Worodria, Bruce Kirenga
BACKGROUND: Equitable access to affordable medicines and diagnostic tests is an integral component of optimal clinical care of patients with asthma and chronic obstructive pulmonary disease (COPD). In Uganda, we lack contemporary data about the availability, cost and affordability of medicines and diagnostic tests essential in asthma and COPD management. METHODS: Data on the availability, cost and affordability of 17 medicines and 2 diagnostic tests essential in asthma and COPD management were collected from 22 public hospitals, 23 private and 85 private pharmacies...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29216116/terahertz-spectrum-splitting-by-a-graphene-covered-array-of-rectangular-grooves
#12
Mohammad Reza Tavakol, Amirhossein Saba, Amir Jafargholi, Amin Khavasi
We propose a bidirectional terahertz (THz) spectrum splitter using a practically simple metamaterial structure consisting of rectangular grooves covered by graphene. Thanks to the graphene optoelectronic tunability and by adjusting the grooves width, this structure provides nearly 2π phase shift. At the same time, the reflection efficiency is acceptable throughout the phase shifts. We design each of the meta-atoms using a circuit model, and then we synthesize the final supercell based on the generalized Snell's law so that the structure reflects different frequency waves to totally different directions...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29213193/anti-inflammatory-activity-of-crude-venom-isolated-from-parasitoid-wasp-bracon-hebetor-say
#13
Evelyn Saba, Tahir Shafeeq, Muhammad Irfan, Yuan Yee Lee, Hyuk-Woo Kwon, Myung Gi Seo, Sang-Joon Park, Kyeong-Yeoll Lee, Man Hee Rhee
Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods. Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods. Venoms injected by stings of various wasps that kill the pest is considered as the examples of the biological method. Although several studies have investigated the biological control of pests through these venoms, very few studies have reported the effects of these venoms on mammalian cells...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29209740/early-deficits-in-insulin-secretion-beta-cell-mass-and-islet-blood-perfusion-precede-onset-of-autoimmune-type-1-diabetes-in-biobreeding-rats
#14
Anya Medina, Saba Parween, Sara Ullsten, Neelanjan Vishnu, Yuk Ting Siu, My Quach, Hedvig Bennet, Alexander Balhuizen, Lina Åkesson, Nils Wierup, Per Ola Carlsson, Ulf Ahlgren, Åke Lernmark, Malin Fex
AIMS/HYPOTHESIS: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ littermates (controls) to investigate beta cell function in vivo, and insulin and glucagon secretion in vitro...
December 6, 2017: Diabetologia
https://www.readbyqxmd.com/read/29207608/gsta1-diplotypes-affect-busulfan-clearance-and-toxicity-in-children-undergoing-allogeneic-hematopoietic-stem-cell-transplantation-a-multicenter-study
#15
Marc Ansari, Patricia Huezo-Diaz Curtis, Chakradhara Rao S Uppugunduri, Mohammed Aziz Rezgui, Tiago Nava, Vid Mlakar, Laurence Lesne, Yves Théoret, Yves Chalandon, Lee L Dupuis, Tao Schechter, Imke H Bartelink, Jaap J Boelens, Robbert Bredius, Jean-Hugues Dalle, Saba Azarnoush, Petr Sedlacek, Victor Lewis, Martin Champagne, Christina Peters, Henrique Bittencourt, Maja Krajinovic
Busulfan (BU) dose adjustment following therapeutic drug monitoring contributes to better outcome of hematopoietic stem cell transplantation (HSCT). Further improvement could be achieved through genotype-guided BU dose adjustments. To investigate this aspect, polymorphism within glutathione S transferase genes were assessed. Particularly, promoter haplotypes of the glutathione S transferase A1 (GSTA1) were evaluated in vitro, with reporter gene assays and clinically, in a pediatric multi-center study (N =138) through association with BU pharmacokinetics (PK) and clinical outcomes...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29199488/which-dietary-patterns-are-more-likely-to-be-associated-with-aspects-of-eco-sustainable-food-behaviours-in-italy
#16
Maria Luisa Scalvedi, Aida Turrini, Anna Saba
Sustainable food consumption (SFC) policies need further investigation into eating habits to improve interventions to encourage shifting to new consumption patterns respectful of human rights, environment and health. Reversing the usual approach focussed on sustainable consumer, the present study investigates how different eating patterns relate to eco-sustainable food. A cluster analysis was carried out on consumption frequencies of food groups recorded in an Italian national survey on 3004 respondents, providing four eating habit segments, further investigated as for sustainable food attitude and behaviour...
December 4, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29198827/systematic-three-dimensional-coculture-rapidly-recapitulates-interactions-between-human-neurons-and-astrocytes
#17
Robert Krencik, Kyounghee Seo, Jessy V van Asperen, Nupur Basu, Caroline Cvetkovic, Saba Barlas, Robert Chen, Connor Ludwig, Chao Wang, Michael E Ward, Li Gan, Philip J Horner, David H Rowitch, Erik M Ullian
Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our ability to model this relationship is hampered by the lack of relevant and convenient tools to recapitulate this complex interaction. To address this barrier, we have devised efficient coculture systems utilizing 3D organoid-like spheres, termed asteroids, containing pre-differentiated human pluripotent stem cell (hPSC)-derived astrocytes (hAstros) combined with neurons generated from hPSC-derived neural stem cells (hNeurons) or directly induced via Neurogenin 2 overexpression (iNeurons)...
November 27, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29198327/critical-features-and-challenges-associated-with-imaging-in-patients-undergoing-cancer-immunotherapy
#18
REVIEW
Cinzia Solinas, Michele Porcu, Zuzana Hlavata, Pushpamali De Silva, Marco Puzzoni, Karen Willard-Gallo, Mario Scartozzi, Luca Saba
Manipulating an individual's immune system through immune checkpoint blockade is revolutionizing the paradigms of cancer treatment. Peculiar patterns and kinetics of response have been observed with these new drugs, rendering the assessment of tumor burden particularly challenging in cancer immunotherapy. The mechanisms of action for immune checkpoint blockade, based upon engagement of the adaptive immune system, can generate unusual response patterns, including pseudoprogression, hyperprogression, atypical and delayed responses...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198048/magnesium-in-breast-cancer-what-is-its-influence-on-the-progression-of-this-disease
#19
REVIEW
Priscyla Maria Vieira Mendes, Daila Leite Chaves Bezerra, Loanne Rocha Dos Santos, Raísa de Oliveira Santos, Stéfany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Sabas Carlos Vieira, Dilina do Nascimento Marreiro
Breast cancer is a disease of high mortality, characterized by the progressive accumulation of mutations that contribute to the uncontrolled development of breast tissue cells. Literature shows that disturbances in mineral homeostasis, such as magnesium, may interfere with tumor progression. The objective of this study is to provide updated information about magnesium's role in the pathogenesis of breast cancer. A review of literature was carried out from a search for articles in the PubMed and CAPES Periodicals databases published between 1995 and 2016 with the cross-references of the descriptors "magnesium," "breast neoplasms," and "oxidative stress" and the corresponding words in Portuguese...
December 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29196862/voluntary-exposure-to-a-toxin-the-genetic-influence-on-ethanol-consumption
#20
Paula L Hoffman, Laura M Saba, Lauren A Vanderlinden, Boris Tabakoff
Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organs to alcohol-induced damage exhibit a strong genetic influence. We have developed an integrative genetic/genomic approach to identify transcriptional networks that predispose complex traits, including propensity for alcohol consumption and propensity for alcohol-induced organ damage...
December 1, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
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