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https://www.readbyqxmd.com/read/28499192/handgrip-strength-is-associated-with-anthropometrics-variables-and-sex-in-preschool-children-a-cross-sectional-study-providing-reference-values
#1
Pedro Ángel Latorre Román, David Mora López, Beatriz Berrios Aguayo, Alejandro Robles Fuentes, Felipe García-Pinillos, Melchor Martínez Redondo
OBJECTIVE: The purpose of this study was to examine the influence of age, sex and anthropometric variables in handgrip strength and to determine norm-referenced values for preschool children. DESIGN: Cross-sectional study. SETTING: Schools. PARTICIPANTS: A total of 1215 children, aged 3-6 years (590 girls and 625 boys). INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Handgrip strength (HS), measured by the CAMRY hydraulic hand dynamometer (EH101; Camry, Guangdong Province, China)...
April 5, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28489890/unmasking-inequalities-sub-national-maternal-and-child-mortality-data-from-two-urban-slums-in-lagos-nigeria-tells-the-story
#2
Erin Anastasi, Ekanem Ekanem, Olivia Hill, Agnes Adebayo Oluwakemi, Oluwatosin Abayomi, Andrea Bernasconi
INTRODUCTION: Nigeria has one of the highest maternal mortality ratios in the world as well as high perinatal mortality. Unfortunately, the country does not have the resources to assess this critical indicator with the conventional health information system and measuring its progress toward the goal of ending preventable maternal deaths is almost impossible. Médecins Sans Frontières (MSF) conducted a cross-sectional study to assess maternal and perinatal mortality in Makoko Riverine and Badia East, two of the most vulnerable slums of Lagos...
2017: PloS One
https://www.readbyqxmd.com/read/28487457/do-outcomes-after-kidney-transplantation-differ-for-black-patients-in-england-versus-new-york-state-a-comparative-population-cohort-analysis
#3
Sanna Tahir, Holly Gillott, Francesca Jackson-Spence, Jay Nath, Jemma Mytton, Felicity Evison, Adnan Sharif
OBJECTIVES: Inferior outcomes for black kidney transplant recipients in the USA may not be generalisable elsewhere. In this population cohort analysis, we compared outcomes for black kidney transplant patients in England versus New York State. DESIGN: Retrospective, comparative, population cohort study utilising administrative data registries. SETTINGS AND PARTICIPANTS: English data were derived from Hospital Episode Statistics, while New York State data were derived from Statewide Planning and Research Cooperative System...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28484124/propensity-score-matched-comparison-of-midterm-angiographic-outcomes-of-sirolimus-versus-everolimus-and-biolimus-eluting-stents-for-de-novo-coronary-stenosis
#4
Kenichiro Suzuki, Tetsuya Ishikawa, Makoto Mutoh, Hiroshi Sakamoto, Chikara Mori, Takayuki Ogawa, Koichi Hashimoto, Takeyuki Kubota, Kimiaki Komukai, Michihiro Yoshimura
We conducted propensity-score matched comparisons of midterm angiographic outcomes of sirolimus (SES) versus either everolimus- (EES) or biolimus- (BES) eluting stents after placements for coronary stenosis in a daily practice environment since previous randomized trials did not demonstrate the superiority of EES and BES over SES in terms of midterm angiographic outcomes.The present study was a non-randomized, retrospective, and lesion-based study, recruiting angiographically followed-up lesions within 550 days after successful and elective SES (n = 1793), EES (n = 1303), or BES (n = 324) placement for de novo native coronary stenosis during the period from August 2004 to January 2014 at 6 institutes...
May 8, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28479831/classification-of-stable-solutions-for-non-homogeneous-higher-order-elliptic-pdes
#5
Abdellaziz Harrabi, Belgacem Rahal, Mohamed Karim Hamdani
Under some assumptions on the nonlinearity f, we will study the nonexistence of nontrivial stable solutions or solutions which are stable outside a compact set of [Formula: see text] for the following semilinear higher-order problem: [Formula: see text] with [Formula: see text]. The main methods used are the integral estimates and the Pohozaev identity. Many classes of nonlinearity will be considered; even the sign-changing nonlinearity, which has an adequate subcritical growth at zero as for example [Formula: see text], where [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text]...
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28452069/the-hdac6-inhibitor-tubacin-induces-release-of-cd133-extracellular-vesicles-from-cancer-cells
#6
Olivia S Chao, Tim C Chang, Maria A Di Bella, Riccardo Alessandro, Fabio Anzanello, Germana Rappa, Oscar B Goodman, Aurelio Lorico
Tumor-derived extracellular vesicles (EVs) are emerging as an important mode of intercellular communication, capable of transferring biologically active molecules that facilitate the malignant growth and metastatic process. CD133 (Prominin-1), a stem cell marker implicated in tumor initiation, differentiation and resistance to anti-cancer therapy, is reportedly associated with EVs in various types of cancer. However, little is known about the factors that regulate the release of these CD133(+) EVs. Here, we report that the HDAC6 inhibitor tubacin promoted the extracellular release of CD133(+) EVs from human FEMX-I metastatic melanoma and Caco-2 colorectal carcinoma cells, with a concomitant downregulation of intracellular CD133...
April 27, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#7
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28413114/left-atrial-appendage-thrombi-relate-to-easily-accessible-clinical-parameters-in-patients-undergoing-atrial-fibrillation-transcatheter-ablation-a-multicenter-study
#8
Matteo Anselmino, Lucia Garberoglio, Sebastiano Gili, Emanuele Bertaglia, Giuseppe Stabile, Raffaella Marazzi, Sakis Themistoclakis, Franceso Solimene, Simone Frea, Walter Grosso Marra, Mara Morello, Marco Scaglione, Roberto De Ponti, Fiorenzo Gaita
BACKGROUND: Transesophageal echocardiography (TEE) is routinely performed before atrial fibrillation (AF) transcatheter ablation to exclude the presence of left atrial (LA) or LA appendage (LAA) thrombi. The aim of the study is to evaluate if easily accessible clinical parameters may relate to the presence of LA or LAA thrombi to identify patients who could potentially avoid TEE. METHODS AND RESULTS: Between January 2012 and September 2014, data from 1539 consecutive patients undergoing TEE, as a work-up before AF transcatheter ablation, in six large volume centers were collected...
April 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28387851/does-intrawound-vancomycin-application-during-spine-surgery-create-vancomycin-resistant-organism
#9
Silky Chotai, Patty W Wright, Andrew T Hale, Whitney A Jones, Matthew J McGirt, Joshua C Patt, Clinton J Devin
BACKGROUND: Surgical site infection (SSI) following spine surgery is a morbid and expensive complication. The use of intrawound vancomycin is emerging as a solution to reduce SSI. The development of vancomycin-resistant pathogens is an understandable concern. OBJECTIVE: To determine the occurrence of vancomycin-resistant SSI in patients with and without use of intrawound vancomycin. METHODS: Patients undergoing elective spine surgery were dichotomized based on whether intrawound vancomycin was applied...
April 6, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28381024/energetic-ultrafast-fiber-laser-sources-tunable-in-1030-1215-nm-for-deep-tissue-multi-photon-microscopy
#10
Wei Liu, Shih-Hsuan Chia, Hsiang-Yu Chung, Rüdiger Greinert, Franz X Kärtner, Guoqing Chang
We demonstrate an energy scalable approach to implement ultrafast fiber laser sources suitable for deep tissue multi-photon microscopy imaging. Enabled by fiber-optic nonlinearities (dominated by self-phase modulation), these unique ultrafast sources produce nearly transform-limited pulses of 50-90 fs in duration with the center wavelength tunable in the wavelength range of 1030-1215 nm. The resulting pulse energy can be scaled up to 20 nJ by optimizing fiber dispersion, shortening fiber length, and using large-mode-area fibers...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28377445/can-visible-signs-predict-concussion-diagnosis-in-the-national-hockey-league
#11
Ruben J Echemendia, Jared M Bruce, Willem Meeuwisse, Michael G Hutchison, Paul Comper, Mark Aubry
BACKGROUND: Early identification and evaluation of concussions is critical. We examined the utility of using visible signs (VS) of concussion in predicting subsequent diagnosis of concussion in NHL players. METHODS: VS of concussion were identified through video review. Coders were trained to detect and record specific visual signs while viewing videos of NHL regular season games. 2460 games were reviewed by at least two independent coders across two seasons. The reliability, sensitivity and specificity of these VS were examined...
April 4, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28369654/sleep-disturbance-and-short-sleep-as-risk-factors-for-depression-and-perceived-medical-errors-in-first-year-residents
#12
David A Kalmbach, J Todd Arnedt, Peter X Song, Constance Guille, Srijan Sen
Study Objectives: While short and poor quality sleep among training physicians has long been recognized as problematic, the longitudinal relationships among sleep, work hours, mood, and work performance are not well understood. Here, we prospectively characterize the risk of depression and medical errors based on preinternship sleep disturbance, internship-related sleep duration, and duty hours. Methods: Survey data from 1215 nondepressed interns were collected at preinternship baseline, then 3 and 6 months into internship...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28362966/does-mis-surgery-allow-for-shorter-constructs-in-the-surgical-treatment-of-adult-spinal-deformity
#13
Juan S Uribe, Joshua Beckman, Praveen V Mummaneni, David Okonkwo, Pierce Nunley, Michael Y Wang, Gregory M Mundis Jr, Paul Park, Robert Eastlack, Neel Anand, Adam Kanter, Frank Lamarca, Richard Fessler, Chris I Shaffrey, Virginie Lafage, Dean Chou, Vedat Deviren
BACKGROUND: The length of construct can potentially influence perioperative risks in adult spinal deformity (ASD) surgery. A head-to-head comparison between open and minimally invasive surgery (MIS) techniques for treatment of ASD has yet to be performed. OBJECTIVE: To examine the impact of MIS approaches on construct length and clinical outcomes in comparison to traditional open approaches when treating similar ASD profiles. METHODS: Two multicenter databases for ASD, 1 involving MIS procedures and the other open procedures, were propensity matched for clinical and radiographic parameters in this observational study...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28315714/cadmium-induced-malignant-transformation-of-rat-liver-cells-potential-key-role-and-regulatory-mechanism-of-altered-apolipoprotein-e-expression-in-enhanced-invasiveness
#14
Masayo Suzuki, Shuso Takeda, Noriko Teraoka-Nishitani, Akane Yamagata, Takahiro Tanaka, Marika Sasaki, Natsuki Yasuda, Makiko Oda, Tatsuji Okano, Kazuhiro Yamahira, Yuta Nakamura, Takanobu Kobayashi, Katsuhito Kino, Hiroshi Miyazawa, Michael P Waalkes, Masufumi Takiguchi
Cadmium is a transition metal that is classified as human carcinogen by the International Agency for Research on Cancer (IARC) with multiple target sites. Many studies using various model systems provide evidence of cadmium-induced malignancy formation in vivo or malignant cell transformation in vitro. Nonetheless, further studies are needed to completely understand the mechanisms of cadmium carcinogenicity. Our prior studies have utilized a rat liver epithelial cell line (TRL 1215) as a model for cadmium-induced malignant transformation...
March 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28302751/impact-of-the-clinical-frailty-scale-on-outcomes-after-transcatheter-aortic-valve-replacement
#15
Tetsuro Shimura, Masanori Yamamoto, Seiji Kano, Ai Kagase, Atsuko Kodama, Yutaka Koyama, Etsuo Tsuchikane, Takahiko Suzuki, Toshiaki Otsuka, Shun Kohsaka, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
Background -The semi-quantitative clinical frailty scale (CFS) is a simple tool to assess patient`s frailty and has been shown to correlate with mortality in elderly patients even when evaluated by non-geriatricians. The aim of the current study was to determine the prognostic value of CFS in patients who underwent transcatheter aortic valve replacement (TAVR). Methods -We utilized the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry to review data of 1215 patients who underwent TAVR...
March 16, 2017: Circulation
https://www.readbyqxmd.com/read/28274651/translucent-zirconia-in-the-ceramic-scenario-for-monolithic-restorations-a-flexural-strength-and-translucency-comparison-test
#16
Michele Carrabba, Andrew J Keeling, Aziz Aziz, Alessandro Vichi, Riccardo Fabian Fonzar, David Wood, Marco Ferrari
OBJECTIVE: To compare three different compositions of Yttria-Tetragonal Zirconia Polycrystal (Y-TZP) ceramic and a lithium disilicate ceramic in terms of flexural strength and translucency. METHODS: Three zirconia materials of different composition and translucency, Aadva ST [ST], Aadva EI [EI] and Aadva NT [NT](GC Tech, Leuven, Belgium) were cut with a slow speed diamond saw into beams and tabs in order to obtain, after sintering, dimensions of 1.2×4.0×15.0mm and 15...
May 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28270777/what-do-you-think-you-are-measuring-a-mixed-methods-procedure-for-assessing-the-content-validity-of-test-items-and-theory-based-scaling
#17
Ingrid Koller, Michael R Levenson, Judith Glück
The valid measurement of latent constructs is crucial for psychological research. Here, we present a mixed-methods procedure for improving the precision of construct definitions, determining the content validity of items, evaluating the representativeness of items for the target construct, generating test items, and analyzing items on a theoretical basis. To illustrate the mixed-methods content-scaling-structure (CSS) procedure, we analyze the Adult Self-Transcendence Inventory, a self-report measure of wisdom (ASTI, Levenson et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28270494/blockade-of-deubiquitylating-enzyme-usp1-inhibits-dna-repair-and-triggers-apoptosis-in-multiple-myeloma-cells
#18
Deepika Sharma Das, Abhishek Das, Arghya Ray, Yan Song, Mehmet K Samur, Nikhil C Munshi, Dharminder Chauhan, Kenneth C Anderson
PURPOSE: The ubiquitin proteasome pathway is a validated therapeutic target in multiple myeloma (MM). Deubiquitylating enzyme USP1 participates in DNA damage response and cellular differentiation pathways. To date, the role of USP1 in MM biology is not defined. In the present study, we investigated the functional significance of USP1 in MM using genetic and biochemical approaches. EXPERIMENTAL DESIGN: To investigate the role of USP1 in myeloma, we utilized USP1 inhibitor SJB3-019A (SJB) for studies in myeloma cell lines and patient MM cells...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28267067/hdac6-inhibition-effectively-reverses-chemotherapy-induced-peripheral-neuropathy
#19
Karen Krukowski, Jiacheng Ma, Olga Golonzhka, Geoffroy O Laumet, Tanuja Gutti, John H van Duzer, Ralph Mazitschek, Matthew B Jarpe, Cobi J Heijnen, Annemieke Kavelaars
Chemotherapy-induced peripheral neuropathy is one of the most common dose-limiting side effects of cancer treatment. Currently, there is no Food and Drug Administration-approved treatment available. Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase whose function includes regulation of α-tubulin-dependent intracellular mitochondrial transport. Here, we examined the effect of HDAC6 inhibition on established cisplatin-induced peripheral neuropathy. We used a novel HDAC6 inhibitor ACY-1083, which shows 260-fold selectivity towards HDAC6 vs other HDACs...
June 2017: Pain
https://www.readbyqxmd.com/read/28242579/comparison-of-two-frailty-indices-in-the-physicians-health-study
#20
Ariela R Orkaby, Tammy T Hshieh, John M Gaziano, Luc Djousse, Jane A Driver
BACKGROUND: As the population ages it is important to identify frailty, a powerful predictor of morbidity and mortality, and often an important unmeasured confounder. We sought to develop a frailty index in the Physician's Health Study (PHS) and estimate the association with mortality. METHODS: Prospective cohort study. Annual questionnaire assessed mood, function and health status. Two frailty scores were compared - cumulative deficit frailty index (PHS FI) and modified Study of Osteoporotic Fracture (mSOF) frailty score...
February 20, 2017: Archives of Gerontology and Geriatrics
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