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https://www.readbyqxmd.com/read/28226276/different-associations-of-albuminuria-with-total-and-cardiovascular-mortality-by-concentrations-of-persistent-organic-pollutants-in-the-elderly
#1
Hyun-Woo Kim, Jung-Hyun Kim, Dong-Won Lee, Sang-Hyun Cho, Ji-Hoon Jung, Ki-Su Kim, Duk-Hee Lee
Epidemiologic studies have indicated that albuminuria is associated with mortality from all causes and cardiovascular disease (CVD), with substantial heterogeneity. We evaluated if the associations of urine albumin creatinine ratio (ACR) with all-cause and CVD mortality differed depending on serum concentrations of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with very long half-lives, which are recently linked to many degenerative diseases. Study subjects were participants of the National Health and Nutrition Examination Survey 1999-2004 who were 60 years or older at baseline (n=1215 and 1067 for organochlorine pesticides (OCPs) and other POPs, respectively)...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28186926/impact-of-screen-time-on-mental-health-problems-progression-in-youth-a-1-year-follow-up-study
#2
Xiaoyan Wu, Shuman Tao, Shichen Zhang, Yukun Zhang, Kaihua Chen, Yajuan Yang, Jiahu Hao, Fangbiao Tao
OBJECTIVES: We examined the relationships between screen time (ST) and mental health problems and also increment of ST and progression of mental health problems in a college-based sample of Chinese youth. METHODS: We assessed 2521 Chinese college freshmen from October 2013 to December 2014. At baseline, the mean age of participants was 18.43 years (SD 0.96 years), and 1215 (48.2%) participants reported ST >2 h/day. We estimated multivariable-adjusted ORs by using logistic regression models for the risk of developing mental health problems (anxiety, depression and psychopathological symptoms) and/or progression of these problems, according to baseline ST exposure and changes in exposure at follow-up...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28169853/interleukin-4-590c-t-rs2243250-polymorphism-is-associated-with-increased-risk-of-atopic-dermatitis-a-meta-analysis-of-case-control-studies
#3
Jingyao Liang, Yumei Liu, Rujun Xue, Lijie Chen, Huiheng Chen, Lei Shao, Jianqin Wang, Xibao Zhang
BACKGROUND: Interleukin 4 (IL-4) -590C/T polymorphism has been reported to influence atopic dermatitis (AD) susceptibility, but the results are controversial. OBJECTIVE: This study was conducted to investigate the association between IL-4 -590C/T polymorphism and AD susceptibility. METHODS: The PubMed, Embase, and China National Knowledge Infrastructure databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were performed to estimate the strength of the association...
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28153211/excessive-daytime-sleepiness-and-its-pattern-among-indian-college-students
#4
Gurjeet Kaur, Amarjeet Singh
The objective of this study was to determine the prevalence and pattern of excessive daytime sleepiness (EDTS) in Indian college students. This was a cross-sectional study that was conducted among 1215 undergraduate students, using the Epworth Sleepiness Scale (ESS) and a sociodemographic survey. A high proportion (45%) of EDTS was observed, and the problem was significantly greater in participants from professional courses. A probability of association of EDTS with coffee/tea consumption, alcohol consumption and smoking was also observed in the study...
January 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28134282/does-von-willebrand-factor-improve-the-predictive-ability-of-current-risk-stratification-scores-in-patients-with-atrial-fibrillation
#5
Amaya García-Fernández, Vanessa Roldán, José Miguel Rivera-Caravaca, Diana Hernández-Romero, Mariano Valdés, Vicente Vicente, Gregory Y H Lip, Francisco Marín
Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined whether its addition to clinical risk stratification schemes improved event-risk prediction. Consecutive outpatients with non-valvular AF were recruited and rates of thrombotic/cardiovascular events, major bleeding and mortality were recorded. The effect of vWF on prognosis was calculated using a Cox regression model. Improvements in predictive accuracy over current scores were determined by calculating the integrated discrimination improvement (IDI), net reclassification improvement (NRI), comparison of receiver-operator characteristic (ROC) curves and Decision Curve Analysis (DCA)...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129912/isolated-sphenoid-sinus-opacification-a-systematic-review
#6
REVIEW
Anna Knisely, Timothy Holmes, Henry Barham, Ray Sacks, Richard Harvey
OBJECTIVE: Unilateral sphenoid sinus opacification (SSO) on imaging is a common incidental radiologic finding. Inflammatory sinus disease is rarely isolated to one sinus cavity therefore SSO raises the potential for neoplastic etiology. The clinical significance of SSO was evaluated and compared to maxillary sinus opacification (MSO). METHODS: A systematic review of unilateral sinus opacification was performed via Medline (1966-January 12th, 2015) and Embase (1980-January 12th, 2015), limited to English literature and human subjects...
January 19, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28106053/risk-of-gastrointestinal-bleeding-among-dabigatran-users-a-self-controlled-case-series-analysis
#7
Wenze Tang, Hsien-Yen Chang, Meijia Zhou, Sonal Singh
This article aims to evaluate the real world risk of gastrointestinal bleeding among users naïve to dabigatran. We adopted a self-controlled case series design. We sampled 1215 eligible adult participants who were continuous insured users between July 1, 2010 and March 31, 2012 with use of dabigatran and at least one gastrointestinal bleeding episode. We used a conditional Poisson regression to estimate incidence rate ratios. The population consisted of 64.69% of male and 60.25% patients equal to or greater than age 65 at start of observation...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28099689/effectiveness-and-safety-of-procalcitonin-evaluation-for-reducing-mortality-in-adults-with-sepsis-severe-sepsis-or-septic-shock
#8
REVIEW
Brenda Ng Andriolo, Regis B Andriolo, Reinaldo Salomão, Álvaro N Atallah
BACKGROUND: Serum procalcitonin (PCT) evaluation has been proposed for early diagnosis and accurate staging and to guide decisions regarding patients with sepsis, severe sepsis and septic shock, with possible reduction in mortality. OBJECTIVES: To assess the effectiveness and safety of serum PCT evaluation for reducing mortality and duration of antimicrobial therapy in adults with sepsis, severe sepsis or septic shock. SEARCH METHODS: We searched the Central Register of Controlled Trials (CENTRAL; 2015, Issue 7); MEDLINE (1950 to July 2015); Embase (Ovid SP, 1980 to July 2015); Latin American Caribbean Health Sciences Literature (LILACS via BIREME, 1982 to July 2015); and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; EBSCO host, 1982 to July 2015), and trial registers (ISRCTN registry, ClinicalTrials...
January 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28069344/the-accuracy-of-burn-diagnosis-codes-in-health-administrative-data-a-validation-study
#9
Stephanie A Mason, Avery B Nathens, James P Byrne, Rob Fowler, Alejandro Gonzalez, Paul J Karanicolas, Rahim Moineddin, Marc G Jeschke
BACKGROUND: Health administrative databases may provide rich sources of data for the study of outcomes following burn. We aimed to determine the accuracy of International Classification of Diseases diagnoses codes for burn in a population-based administrative database. METHODS: Data from a regional burn center's clinical registry of patients admitted between 2006-2013 were linked to administrative databases. Burn total body surface area (TBSA), depth, mechanism, and inhalation injury were compared between the registry and administrative records...
January 6, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28067383/the-functional-consequences-and-prognostic-value-of-dosage-sensitivity-in-ovarian-cancer
#10
Zichuang Yan, Yongjing Liu, Yunzhen Wei, Ning Zhao, Qiang Zhang, Cheng Wu, Zhiqiang Chang, Yan Xu
Copy number alteration (CNA) represents an important class of genetic variations that may contribute to tumorigenesis, tumor growth and metastatic spread. CNA can directly affect the expression of genes within the CNA regions; however, genes within the CNA regions exhibit heterogeneity in gene dosage sensitivity. In this study, a computational framework was built to identify 1170 dosage-sensitive genes (DSGs) and 1215 dosage-resistant genes (DRGs) that were related to ovarian serous cystadenocarcinoma (OV) through the association between CNA and gene expression...
January 9, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28045448/molecular-cloning-characterization-and-functional-analysis-of-acetyl-coa-c-acetyltransferase-and-mevalonate-kinase-genes-involved-in-terpene-trilactone-biosynthesis-from-ginkgo-biloba
#11
Qiangwen Chen, Jiaping Yan, Xiangxiang Meng, Feng Xu, Weiwei Zhang, Yongling Liao, Jinwang Qu
Ginkgolides and bilobalide, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and mevalonate kinase (MVK) as core enzymes. In this study, two full-length (cDNAs) encoding AACT (GbAACT, GenBank Accession No. KX904942) and MVK (GbMVK, GenBank Accession No. KX904944) were cloned from G. biloba. The deduced GbAACT and GbMVK proteins contain 404 and 396 amino acids with the corresponding open-reading frame (ORF) sizes of 1215 bp and 1194 bp, respectively...
January 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28039597/vinorelbine-induced-perforation-of-a-metastatic-gastric-lesion
#12
REVIEW
W J Mullally, C B O'Súilleabháin, C Brady, S O'Reilly
BACKGROUND: Breast carcinoma metastasis to the gastrointestinal tract is rare and more frequently associated with lobular than ductal carcinoma (Borst and Ingold, Surg 114(4):637-641 [1]). The purpose of this article is to present a case based review of a unique gastrointestinal metastasis and literature review. METHODS: A 46 year old lady with metastatic invasive ductal breast cancer was admitted to A&E with sudden onset of epigastric and left shoulder pain. She completed the first cycle of capecitabine/vinorelbine 1 week previously...
December 30, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28038719/testosterone-as-a-marker-of-coronary-artery-disease-severity-in-middle-aged-males
#13
Kunal Gururani, John Jose, Paul V George
Historically, higher levels of serum testosterone were presumed deleterious to the cardiovascular system. In the last two decades, studies have suggested that low testosterone levels are associated with increased prevalence of risk factors for cardiovascular disease (CVD), including dyslipidemia and diabetes. This is a cross sectional study. The aim of our study was to determine the relationship between serum testosterone levels and angiographic severity of coronary artery disease (CAD). Serum testosterone levels were also correlated with flow mediated dilation of brachial artery (BAFMD) - an indicator of endothelial function...
December 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/28035401/acy-1215-accelerates-vemurafenib-induced-cell-death-of-braf-mutant-melanoma-cells-via-induction-of-er-stress-and-inhibition-of-erk-activation
#14
Ueihuei Peng, Zhihao Wang, Sa Pei, Yunchao Ou, Pengchao Hu, Wanhong Liu, Jiquan Song
BRAFV600E mutation is found in ~50% of melanoma patients and BRAFV600E kinase activity inhibitor, vemurafenib, has achieved a remarkable clinical response rate. However, most patients treated with vemurafenib eventually develop resistance. Overcoming primary and secondary resistance to selective BRAF inhibitors remains one of the most critically compelling challenges for these patients. HDAC6 has been shown to confer resistance to chemotherapy in several types of cancer. Few studies focused on the role of HDAC6 in vemurafenib resistance...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/28005234/the-genetic-diversity-and-complete-genome-analysis-of-two-novel-porcine-deltacoronavirus-isolates-in-thailand-in-2015
#15
Athip Lorsirigool, Kepalee Saeng-Chuto, Adthakorn Madapong, Gun Temeeyasen, Thitima Tripipat, Pavita Kaewprommal, Angkana Tantituvanont, Jittima Piriyapongsa, Dachrit Nilubol
Porcine deltacoronavirus (PDCoV) was identified in intestinal samples collected from piglets with diarrhea in Thailand in 2015. Two Thai PDCoV isolates, P23_15_TT_1115 and P24_15_NT1_1215, were isolated and identified. The full-length genome sequences of the P23_15_TT_1115 and P24_15_NT1_1215 isolates were 25,404 and 25,407 nucleotides in length, respectively, which were relatively shorter than that of US and China PDCoV. The phylogenetic analysis based on the full-length genome demonstrated that Thai PDCoV isolates form a new cluster separated from US and China PDCoV but relatively were more closely related to China PDCoV than US isolates...
December 22, 2016: Virus Genes
https://www.readbyqxmd.com/read/28004226/prediction-of-femoral-strength-using-3d-finite-element-models-reconstructed-from-dxa-images-validation-against-experiments
#16
Lorenzo Grassi, Sami P Väänänen, Matti Ristinmaa, Jukka S Jurvelin, Hanna Isaksson
Computed tomography (CT)-based finite element (FE) models may improve the current osteoporosis diagnostics and prediction of fracture risk by providing an estimate for femoral strength. However, the need for a CT scan, as opposed to the conventional use of dual-energy X-ray absorptiometry (DXA) for osteoporosis diagnostics, is considered a major obstacle. The 3D shape and bone mineral density (BMD) distribution of a femur can be reconstructed using a statistical shape and appearance model (SSAM) and the DXA image of the femur...
December 21, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27993968/mechanisms-of-acquired-drug-resistance-to-the-hdac6-selective-inhibitor-ricolinostat-reveals-rational-drug-drug-combination-with-ibrutinib
#17
Jennifer E Amengual, Sathyen A Prabhu, Maximilian Lombardo, Kelly M Zullo, Paul M Johannet, Yulissa Gonzalez, Luigi Scotto, Xavier Jirau-Serrano, Ying Wei, Jimmy K Duong, Renu Nandakumar, Serge Cremers, Akanksha Verma, Olivier Elemento, Owen A O'Connor
PURPOSE: Pan-class I/II histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as potentially more targeted agents. ACY-1215 (ricolinostat) is a first in class selective HDAC6 inhibitor. To better understand the discrete function of HDAC6 and its role in lymphoma, we developed a lymphoma cell line resistant to ACY-1215. EXPERIMENTAL DESIGN: The diffuse large B-cell lymphoma cell line OCI-Ly10 was exposed to increasing concentrations of ACY-1215 over an extended period of time, leading to the development of a resistant cell line...
December 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27968848/effect-of-danhong-injection-on-the-mobilisation-of-endothelial-progenitor-cells-to-vascular-repair-after-percutaneous-coronary-intervention-a-randomised-controlled-trial
#18
Zhen Hu, Hong Wang, Guanwei Fan, Han Zhang, Xiaoying Wang, Jingyuan Mao, Yingqiang Zhao, Yi An, Yuhong Huang, Chuan Li, Lianying Chang, Xianming Chu, Li Li, Yanfen Li, Yuan Zhang, Gangjian Qin, Xiumei Gao, Boli Zhang
BACKGROUND: Endothelial progenitor cells (EPCs) derived from bone marrow are associated with the repair of vascular injury by accelerating re-endothelisation, and represent a potential therapeutic target for ischaemic disease. Danhong injection (DHI), a Chinese Materia Medica standardised product extracted from Radix Salvia miltiorrhiza and Flos Carthamus tinctorius L, is effective in the treatment of ischaemic heart disease. We assessed the effect of DHI on the mobilisation of EPCs and vascular repair mediated by EPCs after percutaneous coronary intervention (PCI)...
October 2016: Lancet
https://www.readbyqxmd.com/read/27958381/a-polymorphism-in-the-oprm1-3-untranslated-region-is-associated-with-methadone-efficacy-in-treating-opioid-dependence
#19
R C Crist, G A Doyle, E C Nelson, L Degenhardt, N G Martin, G W Montgomery, A J Saxon, W Ling, W H Berrettini
The μ-opioid receptor (MOR) is the primary target of methadone and buprenorphine. The primary neuronal transcript of the OPRM1 gene, MOR-1, contains a ~13 kb 3' untranslated region with five common haplotypes in European-Americans. We analyzed the effects of these haplotypes on the percentage of opioid positive urine tests in European-Americans (n=582) during a 24-week, randomized, open-label trial of methadone or buprenorphine/naloxone (Suboxone) for the treatment of opioid dependence. A single haplotype, tagged by rs10485058, was significantly associated with patient urinalysis data in the methadone treatment group...
December 13, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27957719/development-of-improved-hdac6-inhibitors-as-pharmacological-therapy-for-axonal-charcot-marie-tooth-disease
#20
Veronick Benoy, Pieter Vanden Berghe, Matthew Jarpe, Philip Van Damme, Wim Robberecht, Ludo Van Den Bosch
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy, with an estimated prevalence of 1 in 2500. The degeneration of motor and sensory nerve axons leads to motor and sensory symptoms that progress over time and have an important impact on the daily life of these patients. Currently, there is no curative treatment available. Recently, we identified histone deacetylase 6 (HDAC6), which deacetylates α-tubulin, as a potential therapeutic target in axonal CMT (CMT2). Pharmacological inhibition of the deacetylating function of HDAC6 reversed the motor and sensory deficits in a mouse model for mutant "small heat shock protein B1" (HSPB1)-induced CMT2 at the behavioral and electrophysiological level...
December 12, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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