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https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#1
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28413114/left-atrial-appendage-thrombi-relate-to-easily-accessible-clinical-parameters-in-patients-undergoing-atrial-fibrillation-transcatheter-ablation-a-multicenter-study
#2
Matteo Anselmino, Lucia Garberoglio, Sebastiano Gili, Emanuele Bertaglia, Giuseppe Stabile, Raffaella Marazzi, Sakis Themistoclakis, Franceso Solimene, Simone Frea, Walter Grosso Marra, Mara Morello, Marco Scaglione, Roberto De Ponti, Fiorenzo Gaita
BACKGROUND: Transesophageal echocardiography (TEE) is routinely performed before atrial fibrillation (AF) transcatheter ablation to exclude the presence of left atrial (LA) or LA appendage (LAA) thrombi. The aim of the study is to evaluate if easily accessible clinical parameters may relate to the presence of LA or LAA thrombi to identify patients who could potentially avoid TEE. METHODS AND RESULTS: Between January 2012 and September 2014, data from 1539 consecutive patients undergoing TEE, as a work-up before AF transcatheter ablation, in six large volume centers were collected...
April 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28387851/does-intrawound-vancomycin-application-during-spine-surgery-create-vancomycin-resistant-organism
#3
Silky Chotai, Patty W Wright, Andrew T Hale, Whitney A Jones, Matthew J McGirt, Joshua C Patt, Clinton J Devin
BACKGROUND: Surgical site infection (SSI) following spine surgery is a morbid and expensive complication. The use of intrawound vancomycin is emerging as a solution to reduce SSI. The development of vancomycin-resistant pathogens is an understandable concern. OBJECTIVE: To determine the occurrence of vancomycin-resistant SSI in patients with and without use of intrawound vancomycin. METHODS: Patients undergoing elective spine surgery were dichotomized based on whether intrawound vancomycin was applied...
April 6, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28381024/energetic-ultrafast-fiber-laser-sources-tunable-in-1030-1215-nm-for-deep-tissue-multi-photon-microscopy
#4
Wei Liu, Shih-Hsuan Chia, Hsiang-Yu Chung, Rüdiger Greinert, Franz X Kärtner, Guoqing Chang
We demonstrate an energy scalable approach to implement ultrafast fiber laser sources suitable for deep tissue multi-photon microscopy imaging. Enabled by fiber-optic nonlinearities (dominated by self-phase modulation), these unique ultrafast sources produce nearly transform-limited pulses of 50-90 fs in duration with the center wavelength tunable in the wavelength range of 1030-1215 nm. The resulting pulse energy can be scaled up to 20 nJ by optimizing fiber dispersion, shortening fiber length, and using large-mode-area fibers...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28377445/can-visible-signs-predict-concussion-diagnosis-in-the-national-hockey-league
#5
Ruben J Echemendia, Jared M Bruce, Willem Meeuwisse, Michael G Hutchison, Paul Comper, Mark Aubry
BACKGROUND: Early identification and evaluation of concussions is critical. We examined the utility of using visible signs (VS) of concussion in predicting subsequent diagnosis of concussion in NHL players. METHODS: VS of concussion were identified through video review. Coders were trained to detect and record specific visual signs while viewing videos of NHL regular season games. 2460 games were reviewed by at least two independent coders across two seasons. The reliability, sensitivity and specificity of these VS were examined...
April 4, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28369654/sleep-disturbance-and-short-sleep-as-risk-factors-for-depression-and-perceived-medical-errors-in-first-year-residents
#6
David A Kalmbach, J Todd Arnedt, Peter X Song, Constance Guille, Srijan Sen
Study Objectives: While short and poor quality sleep among training physicians has long been recognized as problematic, the longitudinal relationships among sleep, work hours, mood, and work performance are not well understood. Here, we prospectively characterize the risk of depression and medical errors based on preinternship sleep disturbance, internship-related sleep duration, and duty hours. Methods: Survey data from 1215 nondepressed interns were collected at preinternship baseline, then 3 and 6 months into internship...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28362966/does-mis-surgery-allow-for-shorter-constructs-in-the-surgical-treatment-of-adult-spinal-deformity
#7
Juan S Uribe, Joshua Beckman, Praveen V Mummaneni, David Okonkwo, Pierce Nunley, Michael Y Wang, Gregory M Mundis Jr, Paul Park, Robert Eastlack, Neel Anand, Adam Kanter, Frank Lamarca, Richard Fessler, Chris I Shaffrey, Virginie Lafage, Dean Chou, Vedat Deviren
BACKGROUND: The length of construct can potentially influence perioperative risks in adult spinal deformity (ASD) surgery. A head-to-head comparison between open and minimally invasive surgery (MIS) techniques for treatment of ASD has yet to be performed. OBJECTIVE: To examine the impact of MIS approaches on construct length and clinical outcomes in comparison to traditional open approaches when treating similar ASD profiles. METHODS: Two multicenter databases for ASD, 1 involving MIS procedures and the other open procedures, were propensity matched for clinical and radiographic parameters in this observational study...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28315714/cadmium-induced-malignant-transformation-of-rat-liver-cells-potential-key-role-and-regulatory-mechanism-of-altered-apolipoprotein-e-expression-in-enhanced-invasiveness
#8
Masayo Suzuki, Shuso Takeda, Noriko Teraoka-Nishitani, Akane Yamagata, Takahiro Tanaka, Marika Sasaki, Natsuki Yasuda, Makiko Oda, Tatsuji Okano, Kazuhiro Yamahira, Yuta Nakamura, Takanobu Kobayashi, Katsuhito Kino, Hiroshi Miyazawa, Michael P Waalkes, Masufumi Takiguchi
Cadmium is a transition metal that is classified as human carcinogen by the International Agency for Research on Cancer (IARC) with multiple target sites. Many studies using various model systems provide evidence of cadmium-induced malignancy formation in vivo or malignant cell transformation in vitro. Nonetheless, further studies are needed to completely understand the mechanisms of cadmium carcinogenicity. Our prior studies have utilized a rat liver epithelial cell line (TRL 1215) as a model for cadmium-induced malignant transformation...
March 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28302751/impact-of-the-clinical-frailty-scale-on-outcomes-after-transcatheter-aortic-valve-replacement
#9
Tetsuro Shimura, Masanori Yamamoto, Seiji Kano, Ai Kagase, Atsuko Kodama, Yutaka Koyama, Etsuo Tsuchikane, Takahiko Suzuki, Toshiaki Otsuka, Shun Kohsaka, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
Background -The semi-quantitative clinical frailty scale (CFS) is a simple tool to assess patient`s frailty and has been shown to correlate with mortality in elderly patients even when evaluated by non-geriatricians. The aim of the current study was to determine the prognostic value of CFS in patients who underwent transcatheter aortic valve replacement (TAVR). Methods -We utilized the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry to review data of 1215 patients who underwent TAVR...
March 16, 2017: Circulation
https://www.readbyqxmd.com/read/28274651/translucent-zirconia-in-the-ceramic-scenario-for-monolithic-restorations-a-flexural-strength-and-translucency-comparison-test
#10
Michele Carrabba, Andrew J Keeling, Aziz Aziz, Alessandro Vichi, Riccardo Fabian Fonzar, David Wood, Marco Ferrari
OBJECTIVE: To compare three different compositions of Yttria-Tetragonal Zirconia Polycrystal (Y-TZP) ceramic and a lithium disilicate ceramic in terms of flexural strength and translucency. METHODS: Three zirconia materials of different composition and translucency, Aadva ST [ST], Aadva EI [EI] and Aadva NT [NT](GC Tech, Leuven, Belgium) were cut with a slow speed diamond saw into beams and tabs in order to obtain, after sintering, dimensions of 1.2×4.0×15.0mm and 15...
March 6, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28270777/what-do-you-think-you-are-measuring-a-mixed-methods-procedure-for-assessing-the-content-validity-of-test-items-and-theory-based-scaling
#11
Ingrid Koller, Michael R Levenson, Judith Glück
The valid measurement of latent constructs is crucial for psychological research. Here, we present a mixed-methods procedure for improving the precision of construct definitions, determining the content validity of items, evaluating the representativeness of items for the target construct, generating test items, and analyzing items on a theoretical basis. To illustrate the mixed-methods content-scaling-structure (CSS) procedure, we analyze the Adult Self-Transcendence Inventory, a self-report measure of wisdom (ASTI, Levenson et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28270494/blockade-of-deubiquitylating-enzyme-usp1-inhibits-dna-repair-and-triggers-apoptosis-in-multiple-myeloma-cells
#12
Deepika Sharma Das, Abhishek Das, Arghya Ray, Yan Song, Mehmet K Samur, Nikhil C Munshi, Dharminder Chauhan, Kenneth C Anderson
PURPOSE: The ubiquitin proteasome pathway is a validated therapeutic target in multiple myeloma (MM). Deubiquitylating enzyme USP1 participates in DNA damage response and cellular differentiation pathways. To date, the role of USP1 in MM biology is not defined. In the present study, we investigated the functional significance of USP1 in MM using genetic and biochemical approaches. EXPERIMENTAL DESIGN: To investigate the role of USP1 in myeloma, we utilized USP1 inhibitor SJB3-019A (SJB) for studies in myeloma cell lines and patient MM cells...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28267067/hdac6-inhibition-effectively-reverses-chemotherapy-induced-peripheral-neuropathy
#13
Karen Krukowski, Jiacheng Ma, Olga Golonzhka, Geoffroy O Laumet, Tanuja Gutti, John H van Duzer, Ralph Mazitschek, Matthew B Jarpe, Cobi J Heijnen, Annemieke Kavelaars
Chemotherapy-induced peripheral neuropathy is one of the most common dose-limiting side effects of cancer treatment. Currently, there is no Food and Drug Administration-approved treatment available. Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase whose function includes regulation of α-tubulin-dependent intracellular mitochondrial transport. Here, we examined the effect of HDAC6 inhibition on established cisplatin-induced peripheral neuropathy. We used a novel HDAC6 inhibitor ACY-1083, which shows 260-fold selectivity towards HDAC6 vs other HDACs...
March 4, 2017: Pain
https://www.readbyqxmd.com/read/28242579/comparison-of-two-frailty-indices-in-the-physicians-health-study
#14
Ariela R Orkaby, Tammy T Hshieh, John M Gaziano, Luc Djousse, Jane A Driver
BACKGROUND: As the population ages it is important to identify frailty, a powerful predictor of morbidity and mortality, and often an important unmeasured confounder. We sought to develop a frailty index in the Physician's Health Study (PHS) and estimate the association with mortality. METHODS: Prospective cohort study. Annual questionnaire assessed mood, function and health status. Two frailty scores were compared - cumulative deficit frailty index (PHS FI) and modified Study of Osteoporotic Fracture (mSOF) frailty score...
February 20, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28226276/different-associations-of-albuminuria-with-total-and-cardiovascular-mortality-by-concentrations-of-persistent-organic-pollutants-in-the-elderly
#15
Hyun-Woo Kim, Jung-Hyun Kim, Dong-Won Lee, Sang-Hyun Cho, Ji-Hoon Jung, Ki-Su Kim, Duk-Hee Lee
Epidemiologic studies have indicated that albuminuria is associated with mortality from all causes and cardiovascular disease (CVD), with substantial heterogeneity. We evaluated if the associations of urine albumin creatinine ratio (ACR) with all-cause and CVD mortality differed depending on serum concentrations of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with very long half-lives, which are recently linked to many degenerative diseases. Study subjects were participants of the National Health and Nutrition Examination Survey 1999-2004 who were 60 years or older at baseline (n=1215 and 1067 for organochlorine pesticides (OCPs) and other POPs, respectively)...
May 2017: Environmental Research
https://www.readbyqxmd.com/read/28186926/impact-of-screen-time-on-mental-health-problems-progression-in-youth-a-1-year-follow-up-study
#16
Xiaoyan Wu, Shuman Tao, Shichen Zhang, Yukun Zhang, Kaihua Chen, Yajuan Yang, Jiahu Hao, Fangbiao Tao
OBJECTIVES: We examined the relationships between screen time (ST) and mental health problems and also increment of ST and progression of mental health problems in a college-based sample of Chinese youth. METHODS: We assessed 2521 Chinese college freshmen from October 2013 to December 2014. At baseline, the mean age of participants was 18.43 years (SD 0.96 years), and 1215 (48.2%) participants reported ST >2 h/day. We estimated multivariable-adjusted ORs by using logistic regression models for the risk of developing mental health problems (anxiety, depression and psychopathological symptoms) and/or progression of these problems, according to baseline ST exposure and changes in exposure at follow-up...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28169853/interleukin-4-590c-t-rs2243250-polymorphism-is-associated-with-increased-risk-of-atopic-dermatitis-meta-analysis-of-case-control-studies
#17
REVIEW
Jingyao Liang, Yumei Liu, Rujun Xue, Lijie Chen, Huiheng Chen, Lei Shao, Jianqin Wang, Xibao Zhang
BACKGROUND: Interleukin 4 (IL-4) -590C/T polymorphism has been reported to influence atopic dermatitis (AD) susceptibility, but the results are controversial. OBJECTIVE: This meta-analysis was performed to study the association between IL-4 -590C/T polymorphism and AD susceptibility. METHODS: The PubMed, Embase, and China National Knowledge Infrastructure databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were performed to estimate the strength of the association...
March 2017: Dermatitis
https://www.readbyqxmd.com/read/28153211/excessive-daytime-sleepiness-and-its-pattern-among-indian-college-students
#18
Gurjeet Kaur, Amarjeet Singh
The objective of this study was to determine the prevalence and pattern of excessive daytime sleepiness (EDTS) in Indian college students. This was a cross-sectional study that was conducted among 1215 undergraduate students, using the Epworth Sleepiness Scale (ESS) and a sociodemographic survey. A high proportion (45%) of EDTS was observed, and the problem was significantly greater in participants from professional courses. A probability of association of EDTS with coffee/tea consumption, alcohol consumption and smoking was also observed in the study...
January 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28134282/does-von-willebrand-factor-improve-the-predictive-ability-of-current-risk-stratification-scores-in-patients-with-atrial-fibrillation
#19
Amaya García-Fernández, Vanessa Roldán, José Miguel Rivera-Caravaca, Diana Hernández-Romero, Mariano Valdés, Vicente Vicente, Gregory Y H Lip, Francisco Marín
Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined whether its addition to clinical risk stratification schemes improved event-risk prediction. Consecutive outpatients with non-valvular AF were recruited and rates of thrombotic/cardiovascular events, major bleeding and mortality were recorded. The effect of vWF on prognosis was calculated using a Cox regression model. Improvements in predictive accuracy over current scores were determined by calculating the integrated discrimination improvement (IDI), net reclassification improvement (NRI), comparison of receiver-operator characteristic (ROC) curves and Decision Curve Analysis (DCA)...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129912/isolated-sphenoid-sinus-opacification-a-systematic-review
#20
REVIEW
Anna Knisely, Timothy Holmes, Henry Barham, Ray Sacks, Richard Harvey
OBJECTIVE: Unilateral sphenoid sinus opacification (SSO) on imaging is a common incidental radiologic finding. Inflammatory sinus disease is rarely isolated to one sinus cavity therefore SSO raises the potential for neoplastic etiology. The clinical significance of SSO was evaluated and compared to maxillary sinus opacification (MSO). METHODS: A systematic review of unilateral sinus opacification was performed via Medline (1966-January 12th, 2015) and Embase (1980-January 12th, 2015), limited to English literature and human subjects...
March 2017: American Journal of Otolaryngology
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