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https://www.readbyqxmd.com/read/28938587/transcriptomic-profiles-of-human-foreskin-fibroblast-cells-in-response-to-orf-virus
#1
Daxiang Chen, Mingjian Long, Bin Xiao, Yufeng Xiong, Huiqin Chen, Yu Chen, Zhenzhan Kuang, Ming Li, Yingsong Wu, Daniel L Rock, Daoyuan Gong, Yong Wang, Haijian He, Fang Liu, Shuhong Luo, Wenbo Hao
Orf virus has been utilized as a safe and efficient viral vector against not only diverse infectious diseases, but also against tumors. However, the nature of the genes triggered by the vector in human cells is poorly characterized. Using RNA sequencing technology, we compared specific changes in the transcriptomic profiles in human foreskin fibroblast cells following infection by the orf virus. The results indicated that orf virus upregulates or downregulates expression of a variety of genes, including genes involved in antiviral immune response, apoptosis, cell cycle and a series of signaling pathways, such as the IFN and p53-signaling pathways...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28922561/reconciling-female-genital-circumcision-with-universal-human-rights
#2
John-Stewart Gordon
One of the most challenging issues in cross-cultural bioethics concerns the long-standing socio-cultural practice of female genital circumcision (FGC), which is prevalent in many African countries and the Middle East as well as in some Asian and Western countries. It is commonly assumed that FGC, in all its versions, constitutes a gross violation of the universal human rights of health, physical integrity, and individual autonomy and hence should be abolished. This article, however, suggests a mediating approach according to which one form of FGC, the removal of the clitoris foreskin, can be made compatible with the high demands of universal human rights...
September 18, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28918366/a-progressive-reduction-in-autophagic-capacity-contributes-to-induction-of-replicative-senescence-in-hs68-cells
#3
Byeal-I Han, Sung-Hee Hwang, Michael Lee
Autophagy has been implicated in delayed aging and extended longevity. Here, we aimed to study the possible effects of autophagy during the progression of replicative senescence, which is one of the major features of aging. Human foreskin fibroblasts, Hs68 cells, at an initial passage of 15 were serially cultured for several months until they reached cellular senescence. A decrease in cell proliferation was observed during the progression of senescence. Induction of replicative senescence in aged cells (at passage 40) was confirmed by senescence-associated β-galactosidase (SA-β-gal) activity that represents a sensitive and reliable marker for quantifying senescent cells...
September 14, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28912571/comparative-global-immune-related-gene-profiling-of-somatic-cells-human-pluripotent-stem-cells-and-their-derivatives-implication-for-human-lymphocyte-proliferation
#4
Chia-Eng Wu, Chen-Wei Yu, Kai-Wei Chang, Wen-Hsi Chou, Chen-Yu Lu, Elisa Ghelfi, Fang-Chun Wu, Pey-Shynan Jan, Mei-Chi Huang, Patrick Allard, Shau-Ping Lin, Hong-Nerng Ho, Hsin-Fu Chen
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and limited immunogenicity, as reflected by the reduced expression of major histocompatibility complex class-related molecules. Here we investigated the global immune-related gene expression profiles of human ESCs, hiPSCs and somatic cells and identified candidate immune-related genes that may alter their immunogenicity...
September 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28910076/gold-decorated-porous-silicon-nanopillars-for-targeted-hyperthermal-treatment-of-bacterial-infections
#5
Hashim Alhmoud, Anna Cifuentes-Rius, Bahman Delalat, David G Lancaster, Nicolas H Voelcker
In order to address the issue of pathogenic bacterial colonization of diabetic wounds, a more direct and robust approach is required, which relies on a physical form of bacterial destruction in addition to the conventional biochemical approach (i.e. antibiotics). Targeted bacterial destruction through the use of photothermally active nanomaterials has recently come into the spotlight as a viable approach to solving the rising problem of antibiotic resistant microorganisms. Materials with high absorption coefficients in the near infrared (NIR) region of the electromagnetic spectrum show promise as alternative antibacterial therapeutic agents, since they preclude the development of bacterial resistance and can be activated on demand...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28893286/the-biology-of-how-circumcision-reduces-hiv-susceptibility-broader-implications-for-the-prevention-field
#6
REVIEW
Jessica L Prodger, Rupert Kaul
Circumcision reduces heterosexual HIV-1 acquisition in men by at least 60%. However, the biological mechanisms by which circumcision is protective remain incompletely understood. We test the hypothesis that the sub-preputial microenvironment created by the foreskin drives immune activation in adjacent foreskin tissues, facilitating HIV-1 infection through a combination of epithelial barrier disruption, enhanced dendritic cell maturation, and the recruitment/activation of neutrophils and susceptible CD4 T cell subsets such as Th17 cells...
September 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28885326/melanoma-in-situ-of-penis-a-very-rare-entity-a-case-report-and-review-of-the-literature
#7
Roberto Baraziol, Mauro Schiavon, Eugenio Fraccalanza, Gioacchino De Giorgi
RATIONALE: Melanoma in situ of the penis is very rare and there are no clear guidelines for its surgical treatment. PATIENT CONCERNS: The authors describe the case of a 69-year-old man who presented with an asymptomatic brown macula on his glans penis and foreskin that appeared about 8 years earlier, enlarged in the last few months. DIAGNOSES: A diagnostic biopsy showed the characteristics of a melanoma in situ. INTERVENTIONS: The authors decided to excise the lesion keeping a healthy margin of 1 cm all over around except close to the urethral meatus, where it was impossible, and where only 5 mm of free margin was excised...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28878355/comparative-study-on-cellular-entry-of-incinerated-ancient-gold-particles-swarna-bhasma-and-chemically-synthesized-gold-particles
#8
Daniel Beaudet, Simona Badilescu, Kiran Kuruvinashetti, Ahmad Sohrabi Kashani, Dilan Jaunky, Sylvie Ouellette, Alisa Piekny, Muthukumaran Packirisamy
Gold nanoparticles (AuNPs) are used for a number of imaging and therapeutic applications in east and western part of the world. For thousands of years, the traditional Indian Ayurvedic approach to healing involves the use of incinerated gold ash, prepared with a variety of plant extracts and minerals depending on the region. Here, we describe the characterization of incinerated gold particles (IAuPs) in HeLa (human cells derived from cervical cancer) and HFF-1 (human foreskin fibroblast cells) in comparison to synthesized citrate-capped gold nanoparticles (AuNPs)...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874822/carbon-dots-as1411-aptamer-nanoconjugate-for-ultrasensitive-spectrofluorometric-detection-of-cancer-cells
#9
Hasan Motaghi, Masoud Ayatollahi Mehrgardi, Philippe Bouvet
In the present study, a sensitive and selective signal-on method for aptamer based spectrofluorometric detection of cancer cells is introduced. AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells. Nucleolin, is overexpressed on the surface of cancer cells. Mouse breast 4T1, human breast MCF7, and human cervical HeLa cancer cells were selected as target cells, while human foreskin fibroblast cells HFFF-PI6 served as control cells...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874193/extranodal-nasal-type-natural-killer-t-cell-lymphoma-with-penile-involvement-a-case-report-and-review-of-the-literature
#10
Xiaotian Wang, Zimu Gong, Shawn Xiang Li, Wei Yan, Yongsheng Song
BACKGROUND: Extranodal natural killer/T-cell lymphoma (ENKTL) usually presents as a localized disease in the nasal cavity; extension to the male genitourinary system is very rare and has been characterized only recently. Most cases present with predominantly extranodal involvement, advanced stage disease, highly aggressive course, and strong association with Epstein-Barr virus (EBV). While metastasis is common in ENKTLs, the penis is rarely involved in both nasal and non-nasal ENKTLs and only one report was published to date...
September 6, 2017: BMC Urology
https://www.readbyqxmd.com/read/28871492/frequency-of-antibiotic-associated-diarrhea-and-related-complications-in-pediatric-patients-who-underwent-hypospadias-repair-a-comparative-study-using-probiotics-vs-placebo
#11
Ciro Esposito, Agnese Roberti, Francesco Turrà, Mariapina Cerulo, Giovanni Severino, Alessandro Settimi, Maria Escolino
This study aimed to evaluate the effectiveness of probiotics (Lactobacillus rhamnosus GG), as a preventive measure of antibiotic-associated diarrhea (AAD) in children who underwent hypospadias repair and its clinical consequences on postoperative outcome, comparing the group treated with probiotics + antibiotics with two control groups (only antibiotics and antibiotics + placebo). We performed a prospective, randomized, placebo-controlled study with three groups of patients (30 boys for each group) who underwent hypospadias repair in our unit from March 2016 to December 2016...
September 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28868821/paraffin-granuloma-associated-with-buried-glans-penis-induced-sexual-and-voiding-dysfunction
#12
Wonhee Chon, Ja Yun Koo, Min Jung Park, Kyung Un Choi, Hyun Jun Park, Nam Cheol Park
A paraffinoma is a type of inflammatory lipogranuloma that develops after the injection of an artificial mineral oil, such as paraffin or silicon, into the foreskin or the subcutaneous tissue of the penis for the purpose of penis enlargement, cosmetics, or prosthesis. The authors experienced a case of macro-paraffinoma associated with sexual dysfunction, voiding dysfunction, and pain caused by a buried glans penis after a paraffin injection for penis enlargement that had been performed 35 years previously. Herein, this case is presented with a literature review...
August 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28863276/immobilization-of-methotrexate-anticancer-drug-onto-the-graphene-surface-and-interaction-with-calf-thymus-dna-and-4t1-cancer-cells
#13
Reza Karimi Shervedani, Hadiseh Mirhosseini, Marzieh Samiei Foroushani, Mostafa Torabi, Fatemeh Rahnemaye Rahsepar, Leila Norouzi-Barough
Immobilization of methotrexate (MTX) anticancer drug onto the graphene surface is reported through three methods, including either covalent linkage via (a) EDC/NHS organic activators and (b) electrografting of MTX diazonium salt, or (c) noncovalent bonding, resulting in three different systems. To evaluate the interaction ability of the immobilized MTX with biological species, calf thymus DNA (ctDNA), mouse 4T1 breast tumor, and Human foreskin fibroblast (hFF) cells as models of the primary intracellular target of anticancer drugs, cancer and normal cells, respectively, are examined...
August 18, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28856414/foreskin-reconstruction-vs-circumcision-in-distal-hypospadias
#14
Rajay Rampersad, Yoke Lin Nyo, John Hutson, Mike O'Brien, Yves Heloury
PURPOSE: The purpose of the study was to determine if there were differences in the complication rates between foreskin reconstruction (FR) and circumcision (CIRC) in distal hypospadias repairs. The primary outcomes were urethrocutaneous fistula (UF) and dehiscence. METHODS: The data of distal hypospadias operated between 2005 and 2013 were retrospectively reviewed. The inclusion criteria were any distal hypospadias repair that required an urethroplasty. The exclusion criteria were follow-up <1 year, redo procedures, chordee greater than 20°, and incomplete data...
August 30, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28851336/inhibition-of-human-cytomegalovirus-immediate-early-gene-expression-and-replication-by-the-ethyl-acetate-etoac-fraction-of-elaeocarpus-sylvestris-in-vitro
#15
Sohee Bae, Se Chan Kang, Yoon-Jae Song
BACKGROUND: In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously reported that a 70% ethanol extract of Elaeocarpus sylvestris leaves (ESE) inhibits human cytomegalovirus (HCMV) replication in vitro. In the present study, we determined the solvent fraction of ESE that inhibits HCMV replication using activity-guided fractionation. METHODS: Activity-guided fractionation of ESE was performed to determine the solvent fraction that inhibits HCMV replication...
August 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28846521/nontherapeutic-circumcision-of-minors-as-an-ethically-problematic-form-of-iatrogenic-injury
#16
J Steven Svoboda
Nontherapeutic circumcision (NTC) of male infants and boys is a common but misunderstood form of iatrogenic injury that causes harm by removing functional tissue that has known erogenous, protective, and immunological properties, regardless of whether the surgery generates complications. I argue that the loss of the foreskin itself should be counted, clinically and morally, as a harm in evaluating NTC; that a comparison of benefits and risks is not ethically sufficient in an analysis of a nontherapeutic procedure performed on patients unable to provide informed consent; and that circumcision violates clinicians' imperatives to respect patients' autonomy, to do good, to do no harm, and to be just...
August 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28809154/interaction-between-herpesvirus-entry-mediator-and-hsv-2-glycoproteins-mediates-hiv-1-entry-of-hsv-2-infected-epithelial-cells
#17
Kai Hu, Siyi He, Juhua Xiao, Mei Li, Sukun Luo, Mudan Zhang, Qinxue Hu
Herpes simplex virus type 2 (HSV-2) increases human immunodeficiency virus type 1 (HIV-1) acquisition and transmission via unclear mechanisms. Herpesvirus entry mediator (HVEM), an HSV-2 entry receptor, is highly expressed on HIV-1 target cells (CD4+ T cells) and may be incorporated into HIV-1 virions, while HSV-2 glycoproteins can be present on the infected cell surface. Since HVEM-gD interaction together with gB/gH/gL is essential for HSV-2 entry, HVEM-bearing HIV-1 (HIV-1/HVEM) may enter HSV-2-infected cells through such interactions...
September 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28799669/choosing-the-appropriate-shangring-size-for-paediatric-circumcision-using-the-no-flip-technique
#18
Li Fang, Weichao Zhu, Zhongfei Xie, Kerong Wu, Guoyao Wang, Zejun Yan, Zhong Zheng, Qi Ma, Yue Cheng
AIM: To determine the correct ShangRing size for paediatric circumcision using the no-flip technique. METHODS: A cohort of 104 boys (from 6 to 14 years) underwent ShangRing circumcision at Ningbo First Hospital, China. The patients were randomly divided into three groups according to the different methods used for choosing the ring size. For Group A, the ring size was chosen using the ShangRing measuring tape; for Group B, ring size was chosen based on the diameter of penis measured using a self-designed scale plate; and for Group C, ring size was chosen based on the diameter of the glans measured using the self-designed scale plate...
August 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28793897/aqueous-extract-of-phragmitis-rhizoma-ameliorates-myelotoxicity-of-docetaxel-in-vitro-and-in-vivo
#19
Jinhee Kim, You Jin Lee, Young Ah Kim, Eun-Sang Cho, Eunna Huh, Ok-Sun Bang, No Soo Kim
BACKGROUND: A variety of anticancer chemotherapeutics induce adverse side effects including myelotoxicity. Dried roots of Phragmites communis Trinius, Phragmitis rhizoma, have been clinically used in traditional folk medicine to relieve various symptoms like fever. In this study, we evaluated the protective effect of the aqueous extract of Phragmitis rhizoma (EPR) against docetaxel-induced myelotoxicity in vitro and in vivo. METHODS: The in vitro myelo-protective effect of EPR was evaluated using the colony forming unit (CFU) assay with hematopoietic progenitor cells...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28772932/cerium-chloride-application-promotes-wound-healing-and-cell-proliferation-in-human-foreskin-fibroblasts
#20
Liza L Ramenzoni, Franz E Weber, Thomas Attin, Patrick R Schmidlin
This study investigated the effect of cerium chloride (CeCl₃) on cell migration and gene expression of human foreskin fibroblasts (HFF). HFF were exposed to three different CeCl₃ solutions (1%, 5% and 10%, w/v %) for three different time durations (1, 5 and 10 min). 72 h after exposure to CeCl₃, cell viability was assessed by MTT test. A scratch-wounded assay determined the cell migration and the width of the wound, measured at 24 h. Gene expression patterns for cyclins B1, D1 and E1 were analyzed by RT-PCR (p < 0...
May 24, 2017: Materials
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