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https://www.readbyqxmd.com/read/29321505/highly-selective-and-sensitive-macrocycle-based-dinuclear-foldamer-for-fluorometric-and-colorimetric-sensing-of-citrate-in-water
#1
Md Mhahabubur Rhaman, Mohammad H Hasan, Azmain Alamgir, Lihua Xu, Douglas R Powell, Bryan M Wong, Ritesh Tandon, Md Alamgir Hossain
The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29312598/interleukin-22-participates-in-the-inflammatory-process-of-vitiligo
#2
Jinjin Dong, Xiaohong An, Hui Zhong, Yichuan Wang, Jing Shang, Jia Zhou
Vitiligo is an acquired depigmentary skin inflammatory disorder. The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, including interleukin (IL)-1β. IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. Among skin cell populations only keratinocytes are the major targets of IL-22. In the present study, we demonstrated that IL-22 promoting IL-1β secretion from keratinocytes via the Reactive oxygen species (ROS)-NOD-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1 pathway...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29277006/hiv-internalization-into-oral-and-genital-epithelial-cells-by-endocytosis-and-macropinocytosis-leads-to-viral-sequestration-in-the-vesicles
#3
Aizezi Yasen, Rossana Herrera, Kristina Rosbe, Kathy Lien, Sharof M Tugizov
Recently, we showed that HIV-1 is sequestered, i.e., trapped, in the intracellular vesicles of oral and genital epithelial cells. Here, we investigated the mechanisms of HIV-1 sequestration in vesicles of polarized tonsil, foreskin and cervical epithelial cells. HIV-1 internalization into epithelial cells is initiated by multiple entry pathways, including clathrin-, caveolin/lipid raft-associated endocytosis and macropinocytosis. Inhibition of HIV-1 attachment to galactosylceramide and heparan sulfate proteoglycans, and virus endocytosis and macropinocytosis reduced HIV-1 sequestration by 30-40%...
December 22, 2017: Virology
https://www.readbyqxmd.com/read/29249771/synthesis-of-novel-class-of-n-alkyl-isatin-3-iminobenzoic-acid-derivatives-and-their-biological-activity-in-zebrafish-embryos-and-human-cancer-cell-lines
#4
Muhammad Farooq, Zainab M Almarhoon, Nael Abu Taha, Almohannad A R Baabbad, Mohammed A Al-Wadaan, Ayman El-Faham
Isatin (1H-indole-2,3-dione) and many of its derivatives are reported to have pharmacological properties. In this study, we report the synthesis and biological activity of a new class of N-alkyl-isatin-3-iminobenzoic acid derivatives prepared via the condensation of N-alkyl isatin with 4-aminobenzoic acid by conventional, microwave, and ultrasonic methods. Microwave irradiation yielded the products in a shorter reaction time with higher yields and purities. The compounds were screened in zebrafish embryos, and also in three human cancer cell lines (MCF7, HepG2, and Jurkat) and one normal human cell line i...
December 16, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29247317/bilayer-amniotic-membrane-nano-fibrous-fibroin-scaffold-promotes-differentiation-capability-of-menstrual-blood-stem-cells-into-keratinocyte-like-cells
#5
Maryam Fard, Maryam Akhavan-Tavakoli, Sayeh Khanjani, Sona Zare, Haleh Edalatkhah, Shaghayegh Arasteh, Davood Mehrabani, Amir-Hassan Zarnani, Somaieh Kazemnejad, Reza Shirazi
The skin provides a dynamic barrier separating and protecting human body from the exterior world, and then immediate repair and rebuilding of the epidermal barrier is crucial after wound and injury. Wound healing without scars and complete regeneration of skin tissue still remain as a clinical challenge. The demand to engineer scaffolds that actively promote regeneration of damaged areas of the skin has been increased. In this study, menstrual blood-derived stem cells (MenSCs) have been induced to differentiate into keratinocytes-like cells in the presence of human foreskin-derived keratinocytes on a bilayer scaffold based on amniotic membrane and silk fibroin...
December 15, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/29235130/melt-electrospun-bilayered-scaffolds-for-tissue-integration-of-a-suture-less-inflow-cannula-for-rotary-blood-pumps
#6
Sam Liao, Christina Theodoropoulos, Keith A Blackwood, Maria A Woodruff, Shaun D Gregory
Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. The bilayered scaffold consists of a silicone base layer, which mimics the seal, and a melt electrospun polycaprolactone scaffold to serve as a tissue integration layer...
December 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29231289/a-cell-friendly-window-for-the-interaction-of-cells-with-hyaluronic-acid-poly-l-lysine-multilayers
#7
Narayanan Madaboosi, Katja Uhlig, Stephan Schmidt, Anna S Vikulina, Helmuth Möhwald, Claus Duschl, Dmitry Volodkin
Polyelectrolyte multilayers assembled from hyaluronic acid (HA) and poly-l-lysine (PLL) are most widely studied showing excellent reservoir characteristics to host molecules of diverse nature; however, thick (HA/PLL)n films are often found cell repellent. By a systematic study of the adhesion and proliferation of various cells as a function of bilayer number "n" a correlation with the mechanical and chemical properties of films is developed. The following cell lines have been studied: mouse 3T3 and L929 fibroblasts, human foreskin primary fibroblasts VH-Fib, human embryonic kidney HEK-293, human bone cell line U-2-OS, Chinese hamster ovary CHO-K and mouse embryonic stem cells...
December 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29228955/high-efficiency-generation-of-induced-pluripotent-stem-cells-from-human-foreskin-fibroblast-cells-using-the-sagunja-tang-herbal-formula
#8
Ki Mo Kim, Deok Rim Heo, Joo Young Lee, Chang-Seob Seo, Sun-Ku Chung
BACKGROUND: Sagunja-Tang (SGT-4) is a traditional herbal formula in Korean medicine that is used to treat anti-metabolic syndrome, and has antioxidant activity. In this study, we evaluated the effects of SGT-4 on the formation efficiency of induced pluripotent stem cells (iPSCs) from human foreskin fibroblasts (HFFs) by four reprogramming transcription factors: Oct4, Sox2, KIf4, and c-Myc (OSKM). METHODS: SGT-4 contained four different herbal medicines that are composed of Ginseng Radix, Glycyrrhizae Radix et Rhizoma, Atractylodis Rhizoma Alba, and Poria Sclerotium...
December 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29227831/generation-of-hipstz16-ismmsi003-a-cell-line-from-normal-human-foreskin-fibroblasts
#9
Marion Dejosez, Thomas P Zwaka
Human foreskin fibroblasts from a commercial source were reprogrammed into induced pluripotent stem cells to establish a clonal stem cell line, hiPSTZ16 (ISMMSi003-A). These cells show a normal karyotype and full differentiation potential in teratoma assays. The described cells provide a useful resource in combination with other iPS cell lines generated from normal human foreskin fibroblasts to study source- and reprogramming method-independent effects in downstream applications.
December 2, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29215339/the-association-of-congenital-urethral-duplication-and-double-megalourethra
#10
Murat Uçar, Ahsen Karagözlü Akgül, Nizamettin Kılıç, Emin Balkan
BACKGROUND: Urethral duplication and megalourethra are rare urethral anomalies. However, the concomitance of urethral duplication and double megalourethra has not been reported previously. CASE REPORT: A newborn was presented with penile swelling during voiding. Physical examination revealed a retractable foreskin and two external meatus of a double urethra. Retrograde urethrography demonstrated two complete megalourethras. Urethro-urethrostomy and urethroplasty were performed when the patient was 10 months old...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29210523/activities-of-11-azaartemisinin-and-n-sulfonyl-derivatives-against-neospora-caninum-and-comparative-cytotoxicities
#11
Rozanne Harmse, Ho Ning Wong, Frans J Smit, Joachim Müller, Andrew Hemphill, David D N'Da, Richard K Haynes
Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or treatment of the disease in bovines. The peroxide artemisinin and its derivatives used clinically for treatment of malaria are active against N. caninum and other apicomplexan parasites. We have now evaluated the activities of the readily accessible and chemically robust 11-azaartemisinin 5 and selected N-sulfonyl derivatives prepared as described in the accompanying paper against N...
December 6, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29207018/clinical-significance-of-interleukin%C3%A2-6-and-inducible-nitric-oxide-synthase-in-ketamine%C3%A2-induced-cystitis
#12
Chi-Jung Huang, Fa-Kung Lee, Shao-Kuan Chen, Chih-Cheng Chien, Sheng-Tang Wu, Yen-Chieh Wang
Ketamine is an ionotropic glutamatergic N‑methyl‑D‑aspartate receptor antagonist, which is widely used among recreational drug abusers. Ketamine abusers exhibit substantially reduced bladder capacity, which can lead to urinary frequency. The molecular pathogenesis of ketamine‑induced cystitis has been scarcely reported. Given previous clinical findings, it may be hypothesized that pathological alterations in smooth muscle cells (SMCs) of the urinary bladder serve a crucial role in the mechanism underlying cystitis...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29194614/immunomodulatory-effects-of-foreskin-mesenchymal-stromal-cells-fsk-mscs-on-natural-killer-nk-cells
#13
Mehdi Najar, Mohammad Fayyad-Kazan, Nathalie Meuleman, Dominique Bron, Hussein Fayyad-Kazan, Laurence Lagneaux
Foreskin-mesenchymal stromal cells (FSK-MSCs) are immune-privileged thus making them valuable immunotherapeutic cell product. Characterization of the relationship between FSK-MSCs and natural killer (NK) cells is essential to improve cell-based therapy. In the present study, we studied for the first time FSK-MSCs-NK interaction and showed that the result of such cross talk was robustly dependent on the type of cytokines (IL-2, IL-12, IL-15 and IL-21) employed to activate NK cells. Distinctly activated-NK cells showed uneven cytotoxicity against FSK-MSCs, triggering their death in fine...
December 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29173277/exogenous-tumor-necrosis-factor-alpha-could-induce-egress-of-toxoplasma%C3%A2-gondii-from-human-foreskin-fibroblast-cells
#14
Yong Yao, Miao Liu, Cuiping Ren, Jijia Shen, Yongsheng Ji
Toxoplasma gondii is an intra-cellular protozoan parasite that can infect almost all nucleated cells, eliciting host immune responses against infection. Host tissue damage is mainly caused by cellular lysis when T. gondii egresses from infected cells. However, the effects of cytokines released by host immune cells on egression of T. gondii remain elusive. This study aimed to investigate the role of tumor necrosis factor-alpha (TNF-α) on the egress of T. gondii from infected human foreskin fibroblast (HFF) cells and to elucidate the underlying mechanisms that regulate TNF-α-induced egress...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29159692/germacrone-and-sesquiterpene-enriched-extracts-from%C3%A2-curcuma-aeruginosa-roxb-increase-skin-penetration-of-minoxidil-a-hair-growth-promoter
#15
Jukkarin Srivilai, Neti Waranuch, Anothai Tangsumranjit, Nantaka Khorana, Kornkanok Ingkaninan
Minoxidil is approved for topical treatment of androgenic alopecia but hampered by poor cutaneous absorption. Recently, the randomized control trial showed that hair loss treatment of minoxidil was improved by co-application of the anti-androgen, Curcuma aeruginosa Roxb. extract. Here, we aimed to show that the apparent synergism arises from improved cutaneous penetration of minoxidil by bioactive compound, germacrone or C. aeruginosa (as an n-hexane extract, or essential oil). The partition coefficient of germacrone was determined by HPLC...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29157237/isolation-and-identification-of-culturable-fungi-from-the-genitals-and-semen-of-healthy-giant-pandas-ailuropoda-melanoleuca
#16
Xiaoping Ma, Changcheng Li, Jiafa Hou, Yu Gu
BACKGROUND: In order to better understand the possible role of fungi in giant panda reproduction and overall health, it is important to provide a baseline for the normal fungal composition in the reproductive system. Using morphology and internal transcribed spacer (ITS) sequence analysis, we systematically isolated and identified fungal species from the vagina, foreskin, and semen of 21 (11 males and 10 females) healthy giant pandas to understand the normal fungal flora of the genital tracts...
November 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29150196/single-stage-urethroplasty-with-buccal-mucosal-inlay-graft-for-stricture-caused-by-balanitis-xerotica-obliterans-in-boys-outcomes-in-the-medium-term
#17
Junaid Ashraf, Alexander Turner, Ramnath Subramaniam
INTRODUCTION: Balanitis xerotica obliterans (BXO) is a common condition that can affect the foreskin, glans, meatus, and urethra, and rarely can also involve urethra leading to stricture. Numerous procedures have been suggested to treat urethral stricture secondary to BXO but these have had variable results. OBJECTIVE: We describe the first prospective study of a single stage buccal mucosal inlay grafting in children with urethral strictures resistant to existing remedies...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29142410/methanolic-extract-of-costus-pictus-d-don-induces-cytotoxicity-in-liver-hepatocellular-carcinoma-cells-mediated-by-histone-deacetylase-inhibition
#18
P V Neethu, K Suthindhiran, M A Jayasri
Background: Leaves of Costus pictus D. Don, (insulin plant) are used as dietary supplement for the treatment of diabetes. Objective: The antidiabetic activity of this plant is well documented, but its activity on different cell types and mechanism remains unknown. Thus, the present study evaluates the cytotoxicity of C. pictus methanolic extract (CPME) against various cancer and normal cells. Materials and Methods: Dried leaves of C. pictus were extracted using methanol and were subjected to histone deacetylase (HDAC) inhibition and toxicity studies...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137858/human-papillomavirus-e6-and-e7-oncoproteins-affect-the-cell-microenvironment-by-classical-secretion-and-extracellular-vesicles-delivery-of-inflammatory-mediators
#19
Marco Iuliano, Giorgio Mangino, Maria Vincenza Chiantore, Maria Simona Zangrillo, Rosita Accardi, Massimo Tommasino, Gianna Fiorucci, Giovanna Romeo
The connection between chronic inflammation and risk of cancer has been supported by several studies. The development of cancer might be a process driven by the presence of a specific combination of inflammatory mediators, including cytokines, chemokines and enzymes, in the tumor microenvironment. Virus-induced tumors, like HPV-induced Squamous Cell Carcinomas, represent a paradigmatic example of the interplay between inflammation, as integral part of the innate antiviral response, and malignant transformation...
November 11, 2017: Cytokine
https://www.readbyqxmd.com/read/29137231/an-oral-keratinocyte-life-cycle-model-identifies-novel-host-genome-regulation-by-human-papillomavirus-16-relevant-to-hpv-positive-head-and-neck-cancer
#20
Michael R Evans, Claire D James, Oonagh Loughran, Tara J Nulton, Xu Wang, Molly L Bristol, Brad Windle, Iain M Morgan
Many aspects of the HPV life cycle have been characterized in cervical cell lines (W12, CIN612) and in HPV immortalized primary foreskin keratinocytes. There is now an epidemic of HPV positive oropharyngeal cancers (HPV16 is responsible for 80-90% of these); therefore increased understanding of the HPV16 life cycle in oral keratinocytes is a priority. To date there have been limited reports characterizing the HPV16 life cycle in oral keratinocytes. Using TERT immortalized "normal" oral keratinocytes (NOKs) we generated clonal cell lines maintaining the HPV16 genome as an episome, NOKs+HPV16...
October 10, 2017: Oncotarget
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