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https://www.readbyqxmd.com/read/27919079/receptor-usage-dictates-hiv-1-restriction-by-human-trim5%C3%AE-in-dendritic-cell-subsets
#1
Carla M S Ribeiro, Ramin Sarrami-Forooshani, Laurentia C Setiawan, Esther M Zijlstra-Willems, John L van Hamme, Wikky Tigchelaar, Nicole N van der Wel, Neeltje A Kootstra, Sonja I Gringhuis, Teunis B H Geijtenbeek
The most prevalent route of HIV-1 infection is across mucosal tissues after sexual contact. Langerhans cells (LCs) belong to the subset of dendritic cells (DCs) that line the mucosal epithelia of vagina and foreskin and have the ability to sense and induce immunity to invading pathogens. Anatomical and functional characteristics make LCs one of the primary targets of HIV-1 infection. Notably, LCs form a protective barrier against HIV-1 infection and transmission. LCs restrict HIV-1 infection through the capture of HIV-1 by the C-type lectin receptor Langerin and subsequent internalization into Birbeck granules...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27908374/effect-of-lichen-sclerosis-on-success-of-urethroplasty
#2
REVIEW
Michael A Granieri, Andrew C Peterson, Ramiro J Madden-Fuentes
Lichen sclerosis (LS) is a chronic, relapsing disease with a variable presentation. In men, genitourinary LS may affect the penile foreskin, glans, meatus, and urethra. Treatment is multifaceted, ranging from pharmacotherapy to surgery. Urethral reconstruction due to stricture disease from LS is frequently plagued by a high recurrence rate. At the authors' institution, the high recurrence rate has shifted their practice toward potent steroids and minimally invasive surgical techniques. Management of recurrence includes dilation, meatotomy/meatoplasty, 1-stage and 2-stage repairs...
February 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27898732/chemokine-levels-in-the-penile-coronal-sulcus-correlate-with-hiv-1-acquisition-and-are-reduced-by-male-circumcision-in-rakai-uganda
#3
Jessica L Prodger, Ronald H Gray, Brett Shannon, Kamnoosh Shahabi, Xiangrong Kong, Kate Grabowski, Godfrey Kigozi, Fred Nalugoda, David Serwadda, Maria J Wawer, Steven J Reynolds, Cindy M Liu, Aaron A R Tobian, Rupert Kaul
Individual susceptibility to HIV is heterogeneous, but the biological mechanisms explaining differences are incompletely understood. We hypothesized that penile inflammation may increase HIV susceptibility in men by recruiting permissive CD4 T cells, and that male circumcision may decrease HIV susceptibility in part by reducing genital inflammation. We used multi-array technology to measure levels of seven cytokines in coronal sulcus (penile) swabs collected longitudinally from initially uncircumcised men enrolled in a randomized trial of circumcision in Rakai, Uganda...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27894881/comparative-study-of-isolation-expansion-and-characterization-of-epithelial-cells
#4
Sanjay Gottipamula, Sumit K Saraswat, K N Sridhar
BACKGROUND AIMS: The human epithelial cells (EPCs) have been identified as the essential element for the regeneration of skin construct for burns, wounds and various tissue engineer-based products. METHODS: In this study, the isolation, expansion and characterization of EPCs from various sources such as juvenile foreskin (JSK), buccal mucosa (BM), penile skin (PS) and urothelium (UR) in serum-free and xeno-free EpiLife media were evaluated. RESULTS: The growth kinetics study revealed that EPCs from JSK and BM had notably higher growth rates compared with the others...
November 25, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27893837/cell-type-specific-modulation-of-cobalamin-uptake-by-bovine-serum
#5
Hua Zhao, Kalani Ruberu, Hongyun Li, Brett Garner
Tracking cellular 57Co-labelled cobalamin (57Co-Cbl) uptake is a well-established method for studying Cbl homeostasis. Previous studies established that bovine serum is not generally permissive for cellular Cbl uptake when used as a supplement in cell culture medium, whereas supplementation with human serum promotes cellular Cbl uptake. The underlying reasons for these differences are not fully defined. In the current study we address this question. We extend earlier observations by showing that fetal calf serum inhibits cellular 57Co-Cbl uptake by HT1080 cells (a fibrosarcoma-derived fibroblast cell line)...
2016: PloS One
https://www.readbyqxmd.com/read/27863662/surface-assembled-poly-i-c-on-pegylated-plga-microspheres-as-vaccine-adjuvant-apc-activation-and-bystander-cell-stimulation
#6
Annina M Hafner, Blaise Corthésy, Marcus Textor, Hans P Merkle
Biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres are potential vehicles to deliver antigens for vaccination. Because they lack the full capacity to activate professional antigen presenting cells (APCs), combination with an immunostimulatory adjuvant may be considered. A candidate is the synthetic TLR3 ligand polyriboinosinic acid-polyribocytidylic acid, poly(I:C), which drives cell-mediated immunity. However, poly(I:C) has also been linked to the pathogenesis of autoimmunity, as affected by widespread stimulation of non-hematopoietic bystander cells...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27858258/application-of-reflectance-confocal-microscopy-to-evaluate-skin-damage-after-irradiation-with-an-yttrium-scandium-gallium-garnet-ysgg-laser
#7
Xueping Yue, Hongwei Wang, Qing Li, Linfeng Li
The objective of this study was to observe the characteristics of the skin after irradiation with a 2790-nm yttrium-scandium-gallium-garnet (YSGG) laser using reflectance confocal microscopy (RCM). A 2790-nm YSGG laser was used to irradiate fresh foreskin (four doses, at spot density 3) in vitro. The characteristics of microscopic ablative columns (MAC), thermal coagulation zone (TCZ), and microscopic treatment zones (MTZ) were observed immediately after irradiation using digital microscope and RCM. The characteristics of MAC, TCZ, and MTZ with variations in pulse energy were comparatively analyzed...
November 17, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27847256/hypospadias-repair-with-the-glanular-frenular-collar-gfc-technique
#8
Hüseyin Özbey, Şeref Etker
BACKGROUND: In the normal human penis, the glans wings merge in the midline ventrally, but are separated by the 'septum glandis' in conjunction with the frenulum. The frenulum is also included in the formation of the distal (glanular and subcoronal) urethra, which has a special part known as the 'fossa navicularis'. This has inspired a hypospadias repair technique that simulates the development of the glanular and subcoronal urethra, which can be incorporated into the repair of all cases of hypospadias...
November 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27818285/down-regulation-of-microrna-146a-is-associated-with-high-risk-human-papillomavirus-infection-and-epidermal-growth-factor-receptor-overexpression-in-penile-squamous-cell-carcinoma
#9
Elektra Peta, Rocco Cappellesso, Giulia Masi, Alessandro Sinigaglia, Marta Trevisan, Angela Grassi, Barbara Di Camillo, Elisa Vassarotto, Ambrogio Fassina, Giorgio Palù, Luisa Barzon
Dysregulation of host microRNA expression has been involved in the development and progression of human papillomavirus (HPV)-related tumors. Analysis of miR-146a expression in a series of 59 penile squamous cell carcinomas (PSCCs) showed that its levels were lower in high-risk HPV-positive than in HPV-negative PSCCs and inversely correlated with expression of epidermal growth factor receptor (EGFR), a known target for miR-146a. Analysis of genotype distribution for rs2910164, a common functional polymorphism of miR-146a, did not identify correlations with miR-146a levels and EGFR expression in PSCCs...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27789413/generation-of-induced-pluripotent-stem-cell-line-from-foreskin-fibroblasts
#10
Aniela Skrzypczyk, Shibashish Giri, Augustinus Bader
Fibroblasts from the foreskin of a 6-year-old healthy boy was used to generate induced pluripotent stem cell line (ULEIi001-A) by lipotransfection with episomal vectors. Pluripotency and differentiation potential of the cell line was confirmed in vitro. Additionally hepatic differentiation potential of the cell line was investigated.
September 15, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27775307/-balanitis-xerotica-obliterans-underdiagnosed-pathology-of-clinical-relevance
#11
E Calleja Aguayo, A E Hernández Calvarro, C Marhuenda Irastorza
OBJECTIVES: Balanitis xerotica obliterans (BXO) is a chronic inflamatory disease, a genital form of Lichen Sclerosus in males. MATERIAL AND METHODS: This retrospective and descriptive analysis was carried out by rewiew of the medical records of boys who underwent circumcision from April 2013 to April 2014. The study group consisted of boys that were circumcised due it persistant phimosis at 4 years of age, urinary symptoms or painful erection. The histopathological examination was performed only in patients with clinical suspicion of BXO...
July 20, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27770926/interface-design-and-reinforced-features-of-arrowroot-maranta-arundinacea-starch-polyester-based-membranes-preparation-antioxidant-activity-and-cytocompatibility
#12
Chin-San Wu, Hsin-Tzu Liao
The structural, mechanical, antioxidant, and cytocompatibility properties of membranes prepared from the polyhydroxyalkanoate (PHA) and arrowroot (Maranta arundinacea) starch powder (ASP) blend (PHA/ASP) were studied. The acrylic acid-grafted PHA (PHA-g-AA) and the coupling agent treated ASP (TASP) were used to enhance the desired characteristics of these membranes. The PHA-g-AA/TASP membranes had better mechanical properties than the PHA/ASP membrane. This effect was attributed to greater compatibility between the grafted PHA and TASP...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27756722/tight-foreskin
#13
(no author information available yet)
No abstract text is available yet for this article.
October 18, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27755943/cytotoxic-effects-of-urtica-dioica-radix-on-human-colon-ht29-and-gastric-mkn45-cancer-cells-mediated-through-oxidative-and-apoptotic-mechanisms
#14
S Ghasemi, M Moradzadeh, S H Mousavi, H R Sadeghnia
Defects in the apoptotic pathways are responsible for both the colorectal cancer pathogenesis and resistance to therapy. In this study, we examined the level of cellular oxidants, cytotoxicity and apoptosis induced by hydroalcoholic extract of U. dioica radix (0-2000 µg/mL) and oxaliplatin (0-1000 µg/mL, as positive control) in human gastric (MKN45) and colon (HT29) cancer, as well as normal human foreskin fibroblast (HFF) cells. Exposure to U. dioica or oxaliplatin showed a concentration dependent suppression in cell survival with IC50 values of 24...
October 15, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27751834/concealed-epispadias-associated-with-a-buried-penis
#15
Ricardo Sol Melgar, Daniela Gorduza, Delphine Demède, Pierre Mouriquand
OBJECTIVE: The aim was to describe the clinical presentation and the surgical management of penile epispadias associated with a buried penis in five children. PATIENTS AND METHODS: This is a 5-year retrospective review of patients presenting with a buried penis, a congenital defect of the penile skin shaft associated with an unretractable foreskin for whom a penile epispadias was found at the time of surgery. All had undergone surgery combining a Cantwell-Ransley procedure and refashioning of the penile skin following the authors' technique...
September 18, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27707732/tight-foreskin
#16
Aditya Raja, Ian Perry, Hrishi B Joshi
No abstract text is available yet for this article.
October 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27686622/adhesive-ligand-tether-length-affects-the-size-and-length-of-focal-adhesions-and-influences-cell-spreading-and-attachment
#17
Simon J Attwood, Ernesto Cortes, Alexander William M Haining, Benjamin Robinson, Danyang Li, Julien Gautrot, Armando Del Río Hernández
Cells are known to respond to physical cues from their microenvironment such as matrix rigidity. Discrete adhesive ligands within flexible strands of fibronectin connect cell surface integrins to the broader extracellular matrix and are thought to mediate mechanosensing through the cytoskeleton-integrin-ECM linkage. We set out to determine if adhesive ligand tether length is another physical cue that cells can sense. Substrates were covalently modified with adhesive arginylglycylaspartic acid (RGD) ligands coupled with short (9...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686484/reinforcing-the-ventral-penile-shaft-with-pedicled-fat-connective-tissues-before-urethroplasty-lowers-the-risk-for-post-urethroplasty-complications-in-hypospadias
#18
Ryo Sueyoshi, Shogo Seo, Takanori Ochi, Hiroshi Murakami, Yuta Yazaki, Masahiro Takeda, Hiroki Nakamura, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: CHARGE is our technique for reinforcing the ventral penile shaft with pedicled pericordal/scrotal fat, pedicled perimeatal connective tissue, or a combination of these at the time of initial hypospadias surgery. Such pedicled grafts "charge" poorly developed urethral plates and thin ventral foreskin prior to urethroplasty to improve compromised vascular perfusion that could prevent post-urethroplasty complications (post-UPC). METHODS: We reviewed post-UPC in 179 staged hypospadias repair patients (1997-2015)...
September 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27685909/selective-cytotoxic-effect-of-rhododendron-luteum-extract-on-human-colon-and-liver-cancer-cells
#19
Selim Demir, Ibrahim Turan, Yuksel Aliyazicioglu
PURPOSE: The genus Rhododendron is distributed entirely in the world with the exception of South and Central America and Africa, growing in a large diversity of climatic conditions. This genus is a rich source of phenolic compounds, especially flavonoids, essential oils, chromones, terpenoids, and steroids. It has many biological properties such as antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, antidiabetic, immunomodulatory, cardioprotective and hepatoprotective among others due to their polyphenolic constituents...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27663159/skin-photorejuvenation-effects-of-light-emitting-diodes-leds-a-comparative-study-of-yellow-and-red-leds-in%C3%A2-vitro-and-in%C3%A2-vivo
#20
S K Kim, H R You, S H Kim, S J Yun, S C Lee, J B Lee
BACKGROUND: Red-coloured light-emitting diodes (LEDs) can improve skin photorejuvenation and regeneration by increasing cellular metabolic activity. AIM: To evaluate the effectiveness of visible LEDs with specific wavelengths for skin photorejuvenation in vitro and in vivo. METHODS: Normal human dermal fibroblasts (HDFs) from neonatal foreskin were cultured and irradiated in vitro by LEDs at different wavelengths (410-850 nm) and doses (0-10 J/cm(2) )...
October 2016: Clinical and Experimental Dermatology
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