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October 18, 2016: BMJ: British Medical Journal
S Ghasemi, M Moradzadeh, S H Mousavi, H R Sadeghnia
Defects in the apoptotic pathways are responsible for both the colorectal cancer pathogenesis and resistance to therapy. In this study, we examined the level of cellular oxidants, cytotoxicity and apoptosis induced by hydroalcoholic extract of U. dioica radix (0-2000 µg/mL) and oxaliplatin (0-1000 µg/mL, as positive control) in human gastric (MKN45) and colon (HT29) cancer, as well as normal human foreskin fibroblast (HFF) cells. Exposure to U. dioica or oxaliplatin showed a concentration dependent suppression in cell survival with IC50 values of 24...
October 15, 2016: Cellular and Molecular Biology
Ricardo Sol Melgar, Daniela Gorduza, Delphine Demède, Pierre Mouriquand
OBJECTIVE: The aim was to describe the clinical presentation and the surgical management of penile epispadias associated with a buried penis in five children. PATIENTS AND METHODS: This is a 5-year retrospective review of patients presenting with a buried penis, a congenital defect of the penile skin shaft associated with an unretractable foreskin for whom a penile epispadias was found at the time of surgery. All had undergone surgery combining a Cantwell-Ransley procedure and refashioning of the penile skin following the authors' technique...
September 18, 2016: Journal of Pediatric Urology
Aditya Raja, Ian Perry, Hrishi B Joshi
No abstract text is available yet for this article.
October 5, 2016: BMJ: British Medical Journal
Simon J Attwood, Ernesto Cortes, Alexander William M Haining, Benjamin Robinson, Danyang Li, Julien Gautrot, Armando Del Río Hernández
Cells are known to respond to physical cues from their microenvironment such as matrix rigidity. Discrete adhesive ligands within flexible strands of fibronectin connect cell surface integrins to the broader extracellular matrix and are thought to mediate mechanosensing through the cytoskeleton-integrin-ECM linkage. We set out to determine if adhesive ligand tether length is another physical cue that cells can sense. Substrates were covalently modified with adhesive arginylglycylaspartic acid (RGD) ligands coupled with short (9...
September 30, 2016: Scientific Reports
Ryo Sueyoshi, Shogo Seo, Takanori Ochi, Hiroshi Murakami, Yuta Yazaki, Masahiro Takeda, Hiroki Nakamura, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: CHARGE is our technique for reinforcing the ventral penile shaft with pedicled pericordal/scrotal fat, pedicled perimeatal connective tissue, or a combination of these at the time of initial hypospadias surgery. Such pedicled grafts "charge" poorly developed urethral plates and thin ventral foreskin prior to urethroplasty to improve compromised vascular perfusion that could prevent post-urethroplasty complications (post-UPC). METHODS: We reviewed post-UPC in 179 staged hypospadias repair patients (1997-2015)...
September 16, 2016: Journal of Pediatric Surgery
Selim Demir, Ibrahim Turan, Yuksel Aliyazicioglu
PURPOSE: The genus Rhododendron is distributed entirely in the world with the exception of South and Central America and Africa, growing in a large diversity of climatic conditions. This genus is a rich source of phenolic compounds, especially flavonoids, essential oils, chromones, terpenoids, and steroids. It has many biological properties such as antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, antidiabetic, immunomodulatory, cardioprotective and hepatoprotective among others due to their polyphenolic constituents...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
S K Kim, H R You, S H Kim, S J Yun, S C Lee, J B Lee
BACKGROUND: Red-coloured light-emitting diodes (LEDs) can improve skin photorejuvenation and regeneration by increasing cellular metabolic activity. AIM: To evaluate the effectiveness of visible LEDs with specific wavelengths for skin photorejuvenation in vitro and in vivo. METHODS: Normal human dermal fibroblasts (HDFs) from neonatal foreskin were cultured and irradiated in vitro by LEDs at different wavelengths (410-850 nm) and doses (0-10 J/cm(2) )...
October 2016: Clinical and Experimental Dermatology
Tiziana Russo, Monica Currò, Anna Barbera, Daniela Caccamo, Pietro Antonuccio, Salvatore Arena, Angela Simona Montalto, Saveria Parisi, Lucia Marseglia, Eloisa Gitto, Riccardo Ientile, Pietro Impellizzeri, Carmelo Romeo
Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder of unclear etiology. The etiology and the exact molecular mechanisms underlying the disease are still unknown. The human transglutaminase (TG) family consists of several proteins with catalytic activity essential for biological processes. In the present research we investigated the transcript levels of three TGs in patients operated on for congenital phimosis without or with histologically confirmed BXO; Thirty children with acquired phimosis were enrolled...
2016: International Journal of Molecular Sciences
Mohd Israr, Jennifer Biryukov, Eric J Ryndock, Samina Alam, Craig Meyers
Human papillomavirus (HPV) is well recognized as a causative agent for anogenital and oropharyngeal cancers, however, the biology of HPV infection at different mucosal locations, specifically the oral cavity, is not well understood. Importantly, it has yet to be determined if oral tissues are permissive for HPV infection and replication. We investigated for the first time the titers, infectivity, and maturation of HPV16 in oral epithelial versus genital epithelial tissue. We show that infectious HPV16 virions can be produced in oral tissue...
September 15, 2016: Virology
K Eckert, N Janssen, M Franz, P Liedgens
BACKGROUND: Removing boys' foreskins, even for medical reasons, is increasingly and critically discussed. The aim of this study is to retrospectively verify if the indication for the removal of boys' foreskins was justified. The study is based on the records of boys who underwent preputial operation in an outpatient medical office for pediatric surgery. METHODS: Preoperative clinical findings, complaints, applied conservative and/or surgical procedures and histological results of the resected foreskins of boys, who underwent preputial operation between 2013-2015, were retrospectively analyzed...
September 16, 2016: Der Urologe. Ausg. A
Lin Wang, Chi Zhang, Chunyan Li, Michael D Weir, Ping Wang, Mark A Reynolds, Liang Zhao, Hockin H K Xu
Human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs), dental pulp stem cells (hDPSCs) and bone marrow MSCs (hBMSCs) are exciting cell sources in regenerative medicine. However, there has been no report comparing hDPSCs, hBMSCs and hiPSC-MSCs for bone engineering in an injectable calcium phosphate cement (CPC) scaffold. The objectives of this study were to: (1) develop a novel injectable CPC containing hydrogel fibers encapsulating stem cells for bone engineering, and (2) compare cell viability, proliferation and osteogenic differentiation of hDPSCs, hiPSC-MSCs from bone marrow (BM-hiPSC-MSCs) and from foreskin (FS-hiPSC-MSCs), and hBMSCs in CPC for the first time...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Chin-San Wu
The mechanical properties, cytocompatibility, and fabrication of three-dimensional (3D) printing strips of composite materials containing polylactide (PLA) and chitosan (CS) were evaluated. Maleic anhydride-grafted polylactide (PLA-g-MA) and CS were used to enhance the desired characteristics of these composites. The PLA-g-MA/CS materials exhibited better mechanical properties than the PLA/CS composites; this effect was attributed to a greater compatibility between the grafted polyester and CS. The water resistance of the PLA-g-MA/CS composites was greater than that of the PLA/CS composites; cytocompatibility evaluation with human foreskin fibroblasts (FBs) indicated that both materials were nontoxic...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Brian J Morris, John N Krieger, Jeffrey D Klausner
We evaluate recent claims opposing infant male circumcision, a procedure now supported by the evidence-based policy of the American Academy of Pediatrics. We find those criticisms depend on speculative claims about the foreskin and obfuscation of the strong scientific evidence supporting pediatric policy development. An argument that circumcision should be delayed to allow a boy to make up his own mind as an adult fails to appreciate the psychological, scheduling and financial burdens later circumcision entails, so reducing the likelihood that it will occur...
August 8, 2016: World Journal of Clinical Pediatrics
Julia Lange, Frederik Weil, Christoph Riegler, Florian Groeber, Silke Rebhan, Szymon Kurdyn, Miriam Alb, Hermann Kneitz, Götz Gelbrich, Heike Walles, Stephan Mielke
Human artificial skin models are increasingly employed as non-animal test platforms for research and medical purposes. However, the overall histopathological quality of such models may vary significantly. Therefore, the effects of manufacturing protocols and donor sources on the quality of skin models built-up from fibroblasts and keratinocytes derived from juvenile foreskins is studied. Histo-morphological parameters such as epidermal thickness, number of epidermal cell layers, dermal thickness, dermo-epidermal adhesion and absence of cellular nuclei in the corneal layer are obtained and scored accordingly...
October 2016: Biotechnology Journal
Giovanni Paolino, Luca M Muscardin, Chiara Panetta, Michele Donati, Pietro Donati
Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. The histological examination revealed hyperplastic and dilated sebaceous glands, while in some areas these glands showed also a direct attachment with the epidermis...
September 6, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Nadja Zöller, Anke König, Manuel Butting, Roland Kaufmann, August Bernd, Eva Valesky, Stefan Kippenberger
Hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. Stigmatization, physical restrictions and high recurrence rates are only some aspects that illustrate the severe influence impaired wound healing can have on patients' life. The treatment of hypertrophic scars especially keloids is still a challenge. In recent years water-filtered near-infrared irradiation (wIRA) composed of near-infrared (NIR) and a thermal component is applied for an increasing penal of clinical purposes...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Abdullah Alkhenizan, Kossay Elabd
OBJECTIVES: To review the evidence of the benefits and harms of infant male circumcision, and the legal and ethical perspectives of infant male circumcision. METHODS: We conducted a systematic search of the literature using PubMed, EMBASE, and the Cochrane library up to June 2015. We searched the medical law literature using the Westlaw and Lexis Library law literature resources up to June 2015. RESULTS: Male circumcision significantly reduced the risk of urinary tract infections by 87%...
September 2016: Saudi Medical Journal
Jianjun Wang, Ping Zhao, Zhihong Wan, Xueyuan Jin, Yongqian Cheng, Tao Yan, Song Qing, Ning Ding, Shaojie Xin
: The aim of this study was to investigate the differentiation potential of induced pluripotent stem cells (iPSCs) derived from human foreskin fibroblasts (HFFs) into hepatocyte-like cells (HLCs). The iPSCs were firstly induced by transduction of OCT4, SOX2, KLF4, and c-MYC into HFFs using retrovirus. Afterwards, expressions of pluripotency factors were identified by semiquantitative reverse transcription-polymerase chain reaction and immunofluorescence staining, and karyotype, embryoid, and teratoma were observed by microscope...
October 2016: Cell Biochemistry and Function
Abdullah Alawad, Othman Alhazzaa, Saleh Altuwaijri, Mohammad Alkhrayef, Faisal Alagrafi, Ziyad Alhamdan, Abdullah Alenazi, Sultan Alharbi, Mohamed Hammad
The SKiPSc1 induced pluripotent stem (iPS) cell line was generated from Human Neonatal Foreskin Fibroblasts (HNFFs) obtained from a healthy donor infant that were reprogrammed using non-integrating Sendai viral vectors expressing Oct3/4, Sox2, c-Myc, and Klf4.
June 25, 2016: Stem Cell Research
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