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JOURNAL ARTICLE
Edgar Akuffo-Addo, Jaycie Dalson, Kwame Agyei, Samiha Mohsen, Safia Yusuf, Clara Juando-Prats, Jory S Simpson
BACKGROUND: The limited available data suggest that the Canadian surgical workforce does not reflect the racial diversity of the patient population it serves, despite the well-established benefits of patient-provider race concordance. There have been no studies to date that characterize the systemic and individual challenges faced by Black medical students in matching to and successfully finishing training in a surgical specialty within a Canadian context that can explain this underrepresentation...
March 12, 2024: Journal of the American College of Surgeons
#22
JOURNAL ARTICLE
Emma L Wilson, Yizhou Yu, Nuno S Leal, James A Woodward, Nikolaos Patikas, Jordan L Morris, Sarah F Field, William Plumbly, Vincent Paupe, Suvagata R Chowdhury, Robin Antrobus, Georgina E Lindop, Yusuf M Adia, Samantha H Y Loh, Julien Prudent, L Miguel Martins, Emmanouil Metzakopian
Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, and cardiac diseases. Although MERCS have been extensively studied, much remains to be explored. To uncover novel regulators of MERCS, we conducted a genome-wide, flow cytometry-based screen using an engineered MERCS reporter cell line...
March 11, 2024: Cell Death & Disease
#23
Eric Wang, Alexander A Cohen, Luis F Caldera, Jennifer R Keeffe, Annie V Rorick, Yusuf M Aida, Priyanthi N P Gnanapragasam, Pamela J Bjorkman, Arup K Chakraborty
Using computational methods, we designed 60-mer nanoparticles displaying SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by ( i ) creating RBD sequences with 6 mutations in the SARS-COV-2 WA1 RBD that were predicted to retain proper folding and abrogate antibody responses to variable epitopes (mosaic-2 COM s; mosaic-5 COM ), and ( ii ) selecting 7 natural sarbecovirus RBDs (mosaic-7 COM ). These antigens were compared with mosaic-8b, which elicits cross-reactive antibodies and protects from sarbecovirus challenges in animals...
February 28, 2024: bioRxiv
#24
JOURNAL ARTICLE
M A Ashkar, S Kutti Rani, N Vasimalai, Chih-Yu Kuo, Kareem Yusuf, Mani Govindasamy
The rapid fabrication is described of binary electrocatalyst based on a highly porous metal-organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-C3 N4 ) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsychotic drug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2D Zr-MOF@g-C3 N4 was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies...
March 7, 2024: Mikrochimica Acta
#25
JOURNAL ARTICLE
Mehnaz Hossain Meem, Sumaiya Binte Yusuf, Sanaa S Al Abbad, Shofiur Rahman, Mahmoud Al-Gawati, Hamad Albrithen, Abdullah N Alodhayb, Kabir M Uddin
This study investigates the potential of 2-(4-butylbenzyl)-3-hydroxynaphthalene-1,4-dione ( 11 ) and its 12 derivatives as anticancer and biofilm formation inhibitors for methicillin-resistant staphylococcus aureus using in silico methods. The study employed various computational methods, including molecular dynamics simulation molecular docking, density functional theory, and global chemical descriptors, to evaluate the interactions between the compounds and the target proteins. The docking results revealed that compounds 9 , 11 , 13 , and ofloxacin exhibited binding affinities of -7...
2024: Frontiers in Chemistry
#26
JOURNAL ARTICLE
Yusuf Ransome, Josefa L Martinez-Brockman, Deron Galusha, Terri-Ann Thompson, Oswald P Adams, Cruz M Nazario, Maxine Nunez, Marcella Nunez-Smith, Rohan G Maharaj
BACKGROUND: Alcohol use is pervasive in the Caribbean; however, the prevalence and correlates of alcohol use and drinking problems in the elderly have not been extensively studied. METHODS: Data were obtained from the Eastern Caribbean Health Outcomes Research Network (ECHORN) Cohort Study, a cohort study of Caribbean people from Puerto Rico, Barbados, Trinidad, and Tobago, and the U.S. Virgin Islands, collected between 2013 and 2018 (baseline study sample, ages 60+, n = 811)...
March 1, 2024: Addictive Behaviors
#27
EDITORIAL
Jacky M Deng, Salma Elgaili Ahmed, Ernest Awoonor-Williams, Progna Banerjee, Magda H Barecka, Laura E Bickerton, Silvina A Di Pietro, Stanna K Dorn, Kevin Maik Jablonka, Gabriele Laudadio, Elisabeth Kreidt, Helena Mannochio-Russo, Júlio Terra, Olivia Harper Wilkins, Saigopalakrishna S Yerneni, Maha Yusuf
No abstract text is available yet for this article.
February 28, 2024: ACS Central Science
#28
MULTICENTER STUDY
Ahmed A H H Nasser, Manpreet Sidhu, Rohan Prakash, Ansar Mahmood, Khabab Osman, Govind S Chauhan, Rajpal Nandra, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balasubramanian Balakumar, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled M Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad A Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
AIMS: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. METHODS: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality...
February 1, 2024: Bone & Joint Journal
#29
JOURNAL ARTICLE
AbdulRahman Tosho Abdulahi, Roseline Oluwaseun Ogundokun, Ajiboye Raimot Adenike, Mohd Asif Shah, Yusuf Kola Ahmed
Pulmonary diseases are various pathological conditions that affect respiratory tissues and organs, making the exchange of gas challenging for animals inhaling and exhaling. It varies from gentle and self-limiting such as the common cold and catarrh, to life-threatening ones, such as viral pneumonia (VP), bacterial pneumonia (BP), and tuberculosis, as well as a severe acute respiratory syndrome, such as the coronavirus 2019 (COVID-19). The cost of diagnosis and treatment of pulmonary infections is on the high side, most especially in developing countries, and since radiography images (X-ray and computed tomography (CT) scan images) have proven beneficial in detecting various pulmonary infections, many machine learning (ML) models and image processing procedures have been utilized to identify these infections...
February 28, 2024: BMC Medical Imaging
#30
JOURNAL ARTICLE
Rawan A Mahdi, Ali T Naseeb, Mohammad W Almoataz, Dalal R Hubail, Yusuf S Alsaffar
Introduction Gallbladder disease accounts for a significant percentage of surgical admissions per year. A review of these cases was done to assess their hospital impact with an evaluation of the efficacy of radiological modalities in terms of evaluation, ideal use, and clinical application. Therefore, this study aims to review the demographics of the disease, the diagnostic yield of radiological modalities, and the overall outcome in regards to the hospital policies and medical services provided in hopes of achieving suitable clinical pathways, increasing the efficiency of gallbladder disease assessment, and limiting unwarranted investigations...
January 2024: Curēus
#31
JOURNAL ARTICLE
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J Taylor, Xianyong Yin, Kim M Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Giorgio E M Melloni, Stavroula Kanoni, Nigel W Rayner, Ozvan Bocher, Ana Luiza Arruda, Kyuto Sonehara, Shinichi Namba, Simon S K Lee, Michael H Preuss, Lauren E Petty, Philip Schroeder, Brett Vanderwerff, Mart Kals, Fiona Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, Mariaelisa Graff, Fumihiko Takeuchi, Jana Nano, Amel Lamri, Masahiro Nakatochi, Sanghoon Moon, Robert A Scott, James P Cook, Jung-Jin Lee, Ian Pan, Daniel Taliun, Esteban J Parra, Jin-Fang Chai, Lawrence F Bielak, Yasuharu Tabara, Yang Hai, Gudmar Thorleifsson, Niels Grarup, Tamar Sofer, Matthias Wuttke, Chloé Sarnowski, Christian Gieger, Darryl Nousome, Stella Trompet, Soo-Heon Kwak, Jirong Long, Meng Sun, Lin Tong, Wei-Min Chen, Suraj S Nongmaithem, Raymond Noordam, Victor J Y Lim, Claudia H T Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, Laura M Raffield, Bram Peter Prins, Aude Nicolas, Lisa R Yanek, Guanjie Chen, Jennifer A Brody, Edmond Kabagambe, Ping An, Anny H Xiang, Hyeok Sun Choi, Brian E Cade, Jingyi Tan, K Alaine Broadaway, Alice Williamson, Zoha Kamali, Jinrui Cui, Manonanthini Thangam, Linda S Adair, Adebowale Adeyemo, Carlos A Aguilar-Salinas, Tarunveer S Ahluwalia, Sonia S Anand, Alain Bertoni, Jette Bork-Jensen, Ivan Brandslund, Thomas A Buchanan, Charles F Burant, Adam S Butterworth, Mickaël Canouil, Juliana C N Chan, Li-Ching Chang, Miao-Li Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Mary Cushman, John Danesh, Swapan K Das, H Janaka de Silva, George Dedoussis, Latchezar Dimitrov, Ayo P Doumatey, Shufa Du, Qing Duan, Kai-Uwe Eckardt, Leslie S Emery, Daniel S Evans, Michele K Evans, Krista Fischer, James S Floyd, Ian Ford, Oscar H Franco, Timothy M Frayling, Barry I Freedman, Pauline Genter, Hertzel C Gerstein, Vilmantas Giedraitis, Clicerio González-Villalpando, Maria Elena González-Villalpando, Penny Gordon-Larsen, Myron Gross, Lindsay A Guare, Sophie Hackinger, Liisa Hakaste, Sohee Han, Andrew T Hattersley, Christian Herder, Momoko Horikoshi, Annie-Green Howard, Willa Hsueh, Mengna Huang, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Mohammad Arfan Ikram, Martin Ingelsson, Md Tariqul Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Guozhi Jiang, Jost B Jonas, Torben Jørgensen, Frederick K Kamanu, Fouad R Kandeel, Anuradhani Kasturiratne, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M Keaton, Abel N Kho, Chiea-Chuen Khor, Muhammad G Kibriya, Duk-Hwan Kim, Florian Kronenberg, Johanna Kuusisto, Kristi Läll, Leslie A Lange, Kyung Min Lee, Myung-Shik Lee, Nanette R Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Adam E Locke, Tin Louie, Jian'an Luan, Andrea O Luk, Xi Luo, Jun Lv, Julie A Lynch, Valeriya Lyssenko, Shiro Maeda, Vasiliki Mamakou, Sohail Rafik Mansuri, Koichi Matsuda, Thomas Meitinger, Olle Melander, Andres Metspalu, Huan Mo, Andrew D Morris, Filipe A Moura, Jerry L Nadler, Michael A Nalls, Uma Nayak, Ioanna Ntalla, Yukinori Okada, Lorena Orozco, Sanjay R Patel, Snehal Patil, Pei Pei, Mark A Pereira, Annette Peters, Fraser J Pirie, Hannah G Polikowsky, Bianca Porneala, Gauri Prasad, Laura J Rasmussen-Torvik, Alexander P Reiner, Michael Roden, Rebecca Rohde, Katheryn Roll, Charumathi Sabanayagam, Kevin Sandow, Alagu Sankareswaran, Naveed Sattar, Sebastian Schönherr, Mohammad Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, Nobuhiro Shojima, Jennifer A Smith, Wing Yee So, Alena Stančáková, Valgerdur Steinthorsdottir, Adrienne M Stilp, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Unnur Thorsteinsdottir, Brian Tomlinson, Tam C Tran, Fuu-Jen Tsai, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S Udler, Adan Valladares-Salgado, Rob M van Dam, Jan B van Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, Ananda R Wickremasinghe, Ko Willems van Dijk, Daniel R Witte, Chittaranjan S Yajnik, Ken Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Matthew Zawistowski, Liang Zhang, Wei Zheng, Leslie J Raffel, Michiya Igase, Eli Ipp, Susan Redline, Yoon Shin Cho, Lars Lind, Michael A Province, Myriam Fornage, Craig L Hanis, Erik Ingelsson, Alan B Zonderman, Bruce M Psaty, Ya-Xing Wang, Charles N Rotimi, Diane M Becker, Fumihiko Matsuda, Yongmei Liu, Mitsuhiro Yokota, Sharon L R Kardia, Patricia A Peyser, James S Pankow, James C Engert, Amélie Bonnefond, Philippe Froguel, James G Wilson, Wayne H H Sheu, Jer-Yuarn Wu, M Geoffrey Hayes, Ronald C W Ma, Tien-Yin Wong, Dennis O Mook-Kanamori, Tiinamaija Tuomi, Giriraj R Chandak, Francis S Collins, Dwaipayan Bharadwaj, Guillaume Paré, Michèle M Sale, Habibul Ahsan, Ayesha A Motala, Xiao-Ou Shu, Kyong-Soo Park, J Wouter Jukema, Miguel Cruz, Yii-Der Ida Chen, Stephen S Rich, Roberta McKean-Cowdin, Harald Grallert, Ching-Yu Cheng, Mohsen Ghanbari, E-Shyong Tai, Josee Dupuis, Norihiro Kato, Markku Laakso, Anna Köttgen, Woon-Puay Koh, Donald W Bowden, Colin N A Palmer, Jaspal S Kooner, Charles Kooperberg, Simin Liu, Kari E North, Danish Saleheen, Torben Hansen, Oluf Pedersen, Nicholas J Wareham, Juyoung Lee, Bong-Jo Kim, Iona Y Millwood, Robin G Walters, Kari Stefansson, Emma Ahlqvist, Mark O Goodarzi, Karen L Mohlke, Claudia Langenberg, Christopher A Haiman, Ruth J F Loos, Jose C Florez, Daniel J Rader, Marylyn D Ritchie, Sebastian Zöllner, Reedik Mägi, Nicholas A Marston, Christian T Ruff, David A van Heel, Sarah Finer, Joshua C Denny, Toshimasa Yamauchi, Takashi Kadowaki, John C Chambers, Maggie C Y Ng, Xueling Sim, Jennifer E Below, Philip S Tsao, Kyong-Mi Chang, Mark I McCarthy, James B Meigs, Anubha Mahajan, Cassandra N Spracklen, Josep M Mercader, Michael Boehnke, Jerome I Rotter, Marijana Vujkovic, Benjamin F Voight, Andrew P Morris, Eleftheria Zeggini
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4 . Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10-8 ) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported...
February 19, 2024: Nature
#32
JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
#33
JOURNAL ARTICLE
Bahadar S Bhatia, John F Morlese, Sarah Yusuf, Yiting Xie, Bob Schallhorn, David Gruen
OBJECTIVES: This diagnostic study assessed the accuracy of radiologists retrospectively, using the deep learning and natural language processing chest algorithms implemented in Clinical Review version 3.2 for: pneumothorax, rib fractures in digital chest X-ray radiographs (CXR); aortic aneurysm, pulmonary nodules, emphysema, and pulmonary embolism in CT images. METHODS: The study design was double-blind (artificial intelligence [AI] algorithms and humans), retrospective, non-interventional, and at a single NHS Trust...
January 2024: BJR open
#34
JOURNAL ARTICLE
Kerry L Shaw, Christopher R Cooney, Tamra C Mendelson, Michael G Ritchie, Natalie S Roberts, Leeban H Yusuf
A central role for sexual isolation in the formation of new species and establishment of species boundaries has been noticed since Darwin and is frequently emphasized in the modern literature on speciation. However, an objective evaluation of when and how sexual isolation plays a role in speciation has been carried out in few taxa. We discuss three approaches for assessing the importance of sexual isolation relative to other reproductive barriers, including the relative evolutionary rate of sexual trait differentiation, the relative strength of sexual isolation in sympatry, and the role of sexual isolation in the long-term persistence of diverging forms...
February 12, 2024: Cold Spring Harbor Perspectives in Biology
#35
REVIEW
Raheel Chaudhry, Yusuf A Siddique, Ahmad Sebai, Mustafa M Moazam, Ghazala S Virk, Yonas Tamene, Mohamed Hassouba
Cardiovascular disease is the leading cause of mortality and morbidity worldwide. One of the main risk factors for cardiovascular events is hypertension. The use of antihypertensive drugs can protect against these events. It occurs directly through the control of hypertension and indirectly through other cardiovascular effects. This meta-analysis and systematic review aimed to assess the impact of various antihypertensive medications (ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, etc.) on blood pressure and various cardiovascular outcomes...
January 2024: Curēus
#36
JOURNAL ARTICLE
Aisha Farhana, Abdullah Alsrhani, Ruqaih S Alghsham, Wassila Derafa, Yusuf Saleem Khan, Zafar Rasheed
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences' 3' untranslated regions (3'UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this study, we aimed to explore the therapeutic effects of gold nanoparticles (GNP) against IL-6 overexpression and the modulation of miRNA-26a-5p in breast cancer (BC) cells. GNP were synthesized using the trisodium citrate method and characterized through UV-Vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM)...
January 24, 2024: International Journal of Molecular Sciences
#37
REVIEW
Darnifayanti Darnifayanti, Diva Rayyan Rizki, Shakira Amirah, Muhammad Fahd Abdurrahman, Muslim Akmal, S N Abdulmadjid, Sulaiman Yusuf, Muhammad Iqhrammullah
The objective of this systematic review and meta-analysis was elucidating the association of VDR SNPs (FokI, TaqI, BsmI, BgII, and ApaI) with neonatal sepsis. Literature search was performed to retrieve records published until August 2nd, 2023 (PROSPERO registration: CRD42023451355). Meta-analysis was carried out to determine the pooled estimates for Odds Ratio (OR). A total of four studies were included with 500 neonates (250 sepsis cases and 250 healthy controls). There was an association observed between TaqI SNP with neonatal sepsis for CT vs...
March 2024: Journal of Infection and Public Health
#38
REVIEW
Megan McLeod, Julie Torode, Kari Leung, Nirmala Bhoo-Pathy, Christopher Booth, Jade Chakowa, Julie Gralow, Andre Ilbawi, Jacek Jassem, Jeannette Parkes, Merixtell Mallafré-Larrosa, Miriam Mutebi, C S Pramesh, Manju Sengar, Audrey Tsunoda, Karla Unger-Saldaña, Verna Vanderpuye, Aasim Yusuf, Richard Sullivan, Ajay Aggarwal
This Policy Review sourced opinions from experts in cancer care across low-income and middle-income countries (LMICs) to build consensus around high-priority measures of care quality. A comprehensive list of quality indicators in medical, radiation, and surgical oncology was identified from systematic literature reviews. A modified Delphi study consisting of three 90-min workshops and two international electronic surveys integrating a global range of key clinical, policy, and research leaders was used to derive consensus on cancer quality indicators that would be both feasible to collect and were high priority for cancer care systems in LMICs...
February 2024: Lancet Oncology
#39
JOURNAL ARTICLE
Yusuf S Althobaiti
Prescription drug abuse is an issue that is rapidly growing globally. Pregabalin, an anticonvulsant, analgesic, and anxiolytic medication, is effective in the management of multiple neurological disorders; however, there is increasing concern regarding its widespread illicit use. It has been previously reported in mice that pregabalin can induce conditioned place preference. In this current investigation, the potential of pregabalin to elicit free-choice drinking in a mouse model of drug addiction, and its effect on recognition and withdrawal behaviors after forced abstinence, were studied...
February 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
#40
JOURNAL ARTICLE
Kaitlin Tabaracci, Norbert T Bokros, Yusuf Oduntan, Bharath Kunduru, Joseph DeKold, Endalkachew Mengistie, Armando McDonald, Christopher J Stubbs, Rajandeep S Sekhon, Seth DeBolt, Daniel J Robertson
Stalk lodging (structural failure crops prior to harvest) significantly reduces annual yields of vital grain crops. The lack of standardized, high throughput phenotyping methods capable of quantifying biomechanical plant traits prevents comprehensive understanding of the genetic architecture of stalk lodging resistance. A phenotyping pipeline developed to enable higher throughput biomechanical measurements of plant traits related to stalk lodging is presented. The methods were developed using principles from the fields of engineering mechanics and metrology and they enable retention of plant-specific data instead of averaging data across plots as is typical in most phenotyping studies...
June 2024: MethodsX
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