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https://www.readbyqxmd.com/read/29220676/penetrance-of-polygenic-obesity-susceptibility-loci-across-the-body-mass-index-distribution
#1
Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C Engert, Salim Yusuf, Hertzel C Gerstein, Sonia S Anand, David Meyre
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%)-rs1421085 (FTO; p = 8.69 × 10-15), rs6235 (PCSK1; p = 7...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29200892/trends-and-drivers-of-skilled-birth-attendant-use-in-nigeria-1990-2013-policy-implications-for-child-and-maternal-health
#2
Adeniyi F Fagbamigbe, Elizabeth O Hurricane-Ike, Oyindamola B Yusuf, Erhabor S Idemudia
Introduction: While Nigeria accounts for only 2% of the world population, it regrettably shares 14% of global maternal death burden. Whether its reported increase in antenatal care utilization is accompanied by increased use of skilled birth attendants (SBAs) is not known. This study assessed trends in utilization of SBAs in Nigeria between 1990 and 2013 and identified its determinants. Methods: Data from four consecutive Nigerian Demographic and Health Survey reports between 1990 and 2013 were pooled...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29181855/liposomal-encapsulation-of-silver-nanoparticles-enhances-cytotoxicity-and-causes-induction-of-reactive-oxygen-species-independent-apoptosis
#3
A Yusuf, A Brophy, B Gorey, A Casey
Silver nanoparticles (AgNP) are one of the most widely investigated metallic NPs due to their promising antibacterial activities. In recent years, AgNP research has shifted beyond antimicrobial use to potential applications in the medical arena. This shift coupled with the extensive commercial applications of AgNP will further increase human exposure and the subsequent risk of adverse effects that may result from repeated exposures and inefficient delivery, meaning research into improved AgNP delivery is of paramount importance...
November 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29174641/effects-of-sequential-ethanol-exposure-and-repeated-high-dose-methamphetamine-on-striatal-and-hippocampal-dopamine-serotonin-and-glutamate-tissue-content-in-wistar-rats
#4
Atiah H Almalki, Sujan C Das, Fahad S Alshehri, Yusuf S Althobaiti, Youssef Sari
Alcohol (ethanol) and methamphetamine (METH) co-abuse is a major public health issue. Ethanol or METH exposure has been associated with changes in neurotransmitter levels in several central brain regions. However, little is known about the effect of sequential exposure to ethanol and METH on glutamate, dopamine and serotonin tissue content in striatum and hippocampus. In this study, we investigated the effects of sequential exposure to ethanol and METH on tissue content of these neurotransmitters. Male Wistar rats were orally gavaged with either ethanol (6g/kg) or water for seven days...
November 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29171317/basal-blood-dhea-s-cortisol-levels-predicts-emdr-treatment-response-in-adolescents-with-ptsd
#5
Mirac Baris Usta, Yusuf Yasin Gumus, Gokce Nur Say, Abdullah Bozkurt, Berkan Şahin, Koray Karabekiroğlu
OBJECTIVE: In literature, recent evidence has shown that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in patients with post-traumatic stress disorder (PTSD) and HPA axis hormones may predict the psychotherapy treatment response in patients with PTSD. In this study, it was aimed to investigate changing cortisol and DHEA-S levels post-eye movement desensitization and reprocessing (EMDR) therapy and the relationship between treatment response and basal cortisol, and DHEA-S levels before treatment...
November 24, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29134983/anti-hyperglycaemic-effects-of-rutin-on-blood-glucose-oxidative-stress-biomarkers-and-lipid-peroxidation-in-alloxan-induced-hyperglycaemic-wistar-rats
#6
Y Tanko, A I Salisu, K A Mohammed, S A Musa, A Jimoh, R Yusuf
The present study investigated the anti-hyperglycaemic effect of rutin on blood glucose, oxidative stressbiomarkers and lipid peroxidation in alloxan induced hyperglycaemic wistar rats. Diabetes was induced in rats by anintraperitoneal (i.p) injection of alloxan monohydrate 150 mg/kg body weight. Twenty five wistar rats were divided asfollows; Group1 served as diabetic control received distilled water 2 mg/kg, Group served as positive control received 2mg/kg glibenclamide, 3, 4 and 5 received rutin at 50, 100 and 200 mg/kg body weight for 28 days respectively...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29132880/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-peripheral-or-carotid-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#7
Sonia S Anand, Jackie Bosch, John W Eikelboom, Stuart J Connolly, Rafael Diaz, Peter Widimsky, Victor Aboyans, Marco Alings, Ajay K Kakkar, Katalin Keltai, Aldo P Maggioni, Basil S Lewis, Stefan Störk, Jun Zhu, Patricio Lopez-Jaramillo, Martin O'Donnell, Patrick J Commerford, Dragos Vinereanu, Nana Pogosova, Lars Ryden, Keith A A Fox, Deepak L Bhatt, Frank Misselwitz, John D Varigos, Thomas Vanassche, Alvaro A Avezum, Edmond Chen, Kelley Branch, Darryl P Leong, Shrikant I Bangdiwala, Robert G Hart, Salim Yusuf
BACKGROUND: Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. METHODS: This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29132879/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-coronary-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#8
Stuart J Connolly, John W Eikelboom, Jackie Bosch, Gilles Dagenais, Leanne Dyal, Fernando Lanas, Kaj Metsarinne, Martin O'Donnell, Anthony L Dans, Jong-Won Ha, Alexandr N Parkhomenko, Alvaro A Avezum, Eva Lonn, Liu Lisheng, Christian Torp-Pedersen, Petr Widimsky, Aldo P Maggioni, Camilo Felix, Katalin Keltai, Masatsugu Hori, Khalid Yusoff, Tomasz J Guzik, Deepak L Bhatt, Kelley R H Branch, Nancy Cook Bruns, Scott D Berkowitz, Sonia S Anand, John D Varigos, Keith A A Fox, Salim Yusuf
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29132159/aspirin-in-patients-with-previous-percutaneous-coronary-intervention-undergoing-noncardiac-surgery
#9
Michelle M Graham, Daniel I Sessler, Joel L Parlow, Bruce M Biccard, Gordon Guyatt, Kate Leslie, Matthew T V Chan, Christian S Meyhoff, Denis Xavier, Alben Sigamani, Priya A Kumar, Marko Mrkobrada, Deborah J Cook, Vikas Tandon, Jesus Alvarez-Garcia, Juan Carlos Villar, Thomas W Painter, Giovanni Landoni, Edith Fleischmann, Andre Lamy, Richard Whitlock, Yannick Le Manach, Meylin Aphang-Lam, Juan P Cata, Peggy Gao, Nicolaas C S Terblanche, Pamidimukkala V Ramana, Kim A Jamieson, Amal Bessissow, Gabriela R Mendoza, Silvia Ramirez, Pierre A Diemunsch, Salim Yusuf, P J Devereaux
Background: Uncertainty remains about the effects of aspirin in patients with prior percutaneous coronary intervention (PCI) having noncardiac surgery. Objective: To evaluate benefits and harms of perioperative aspirin in patients with prior PCI. Design: Nonprespecified subgroup analysis of a multicenter factorial trial. Computerized Internet randomization was done between 2010 and 2013. Patients, clinicians, data collectors, and outcome adjudicators were blinded to treatment assignment...
November 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29124946/factors-affecting-life-satisfaction-of-older-adults-in-turkey
#10
Sevilay S Celik, Yusuf Celik, Neset Hikmet, Mahmud M Khan
This study aimed to examine the determinants of life satisfaction of older adults in Turkey. The sample consisted of 2,959 older adults over 65 years. The effects of psychological, daily life and instrumental activity, physical health and health status, and other important variables on life satisfaction were analyzed. The variables lessening life satisfaction for older adults included poverty, a lower self-reported health status, a decline in physical health, ability to chew, ability to do household activities, and an increase in feelings of depression and feeling social withdrawn...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29101117/double-dose-versus-standard-dose-clopidogrel-according-to-smoking-status-among-patients-with-acute-coronary-syndromes-undergoing-percutaneous-coronary-intervention
#11
Matthias Bossard, Christopher B Granger, Jean-Francois Tanguay, Gilles Montalescot, David P Faxon, Sanjit S Jolly, Petr Widimsky, Kari Niemela, Philippe Gabriel Steg, Madhu K Natarajan, Peggy Gao, Keith A A Fox, Salim Yusuf, Shamir R Mehta
BACKGROUND: Prior Studies have suggested better outcomes in smokers compared with nonsmokers receiving clopidogrel ("smoker's paradox"). The impact of a more intensive clopidogrel regimen on ischemic and bleeding risks in smokers with acute coronary syndromes requiring percutaneous coronary interventions remains unclear. METHODS AND RESULTS: We analyzed 17 263 acute coronary syndrome patients undergoing percutaneous coronary intervention from the CURRENT-OASIS 7 (Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organization to Assess Strategies in Ischemic Symptoms) trial, which compared double-dose (600 mg day 1;150 mg days 2-7; then 75 mg daily) versus standard-dose (300 mg day 1; then 75 mg daily) clopidogrel in acute coronary syndrome patients...
November 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29093481/midgut-bacterial-diversity-of-wild-populations-of-phlebotomus-p-papatasi-the-vector-of-zoonotic-cutaneous-leishmaniasis-zcl-in-turkey
#12
Mehmet Karakuş, Burçin Karabey, Şaban Orçun Kalkan, Güven Özdemir, Gizem Oğuz, Özge Erişöz Kasap, Bülent Alten, Seray Töz, Yusuf Özbel
Phlebotomine sand flies are hematophagous insects that harbor bacterial, viral and parasitic agents like Bartonella sp., Phleboviruses and Leishmania spp., respectively. There are few reports on bacterial microbiota of Phlebotomus (P.) papatasi but no data available for natural populations of Turkey, where leishmaniasis is endemic. Therefore, we aimed to investigate the midgut bacterial flora of different populations of P. papatasi. Sand flies were collected from different towns (Karaburun, Urla, Ayvacik and Başçayır) located in the western part of Turkey...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092960/quantification-of-3-ketodihydrosphingosine-using-hplc-esi-ms-ms-to-study-spt-activity-in-yeast-saccharomyces-cerevisiae
#13
Jihui Ren, Justin Snider, Michael V Airola, Aaron Zhong, Nadia A Rana, Lina M Obeid, Yusuf A Hannun
Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT. With this technique we were able to detect 3KDS at a level comparable to that of dihydrosphingosine (DHS) in yeast S.cerevisiae. An in vitro SPT assay measuring the incorporation of deuterated serine into deuterated 3KDS was developed. The results show that SPT kinetics in response to palmitoyl-CoA fit into an allosteric sigmoidal model, suggesting the existence of more than one palmitoyl-CoA binding site on yeast SPT and positive cooperativity between them...
November 1, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29092626/isolation-and-characterization-of-four-novel-%C3%AE-sitosteryl-esters-from-salvadora-persica-linn
#14
Maria Khan, Mohammad Yusuf, Majed Al Robaian, Mohammed Ali
Salvadora persica is virtuous to have a variety of phytoconstituents responsible for many biological activities some of them identified particularly while some are still to be acknowledged. A number of steroidal, glycosidic, terpenoids, saponins and functional esters are reported till date. The present study deals with extraction, isolation, and characterisation of four novel steroidal esters by systematic cold extraction of S. persica. The extracted phytoconstituents were characterised by sophisticated spectral UV, IR, NMR and MS, techniques...
November 2, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29078844/risk-of-ischemic-heart-disease-in-patients-with-sj%C3%A3-gren-s-syndrome
#15
Faraz Khan Luni, Sonia Ali Malik, Abdur Rahman Khan, Haris Riaz, Hemindermeet Singh, Douglas Federman, Yusuf Kanjwal, Osama Dasa, Sadik Khuder, Ameer Kabour
BACKGROUND: Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren's syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using the Healthcare Cost and Utilization Project National Inpatient Sample 2011 database. MATERIALS AND METHODS: The Healthcare Cost and Utilization Project administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits and ambulatory surgery in all U...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29067778/dentists-most-common-practices-when-selecting-an-implant-system
#16
Ahed Al-Wahadni, Mohamed S Barakat, Khladoon Abu Afifeh, Yusuf Khader
PURPOSE: To report a comprehensive description of dental implant system selection practices among dentists practicing implantology worldwide. MATERIALS AND METHODS: An online questionnaire was designed and sent to members of 15 dental implant organizations. The survey questions addressed: dental implant system selection criteria, implant design variables, dentists' perspective to implant quality stamps, and dentists' satisfaction with their implant system(s). Responses were compiled and analyzed to determine correlation of responses using the chi-squared test (level of significance α ≤ 0...
October 25, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29066611/prognostic-validation-of-a-non-laboratory-and-a-laboratory-based-cardiovascular-disease-risk-score-in-multiple-regions-of-the-world
#17
Philip Joseph, Salim Yusuf, Shun Fu Lee, Quazi Ibrahim, Koon Teo, Sumathy Rangarajan, Rajeev Gupta, Annika Rosengren, Scott A Lear, Alvaro Avezum, Patricio Lopez-Jaramillo, Sadi Gulec, Afzalhussein Yusufali, Jephat Chifamba, Fernando Lanas, Rajesh Kumar, Noushin Mohammadifard, Viswanathan Mohan, Prem Mony, Annamarie Kruger, Xu Liu, Baoxia Guo, Wenqi Zhao, Youzhu Yang, Rajamohanan Pillai, Rafael Diaz, Ambigga Krishnapillai, Romaina Iqbal, Rita Yusuf, Andrzej Szuba, Sonia S Anand
OBJECTIVE: To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS). METHODS: Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100 475) and FC-IHRS (n=107 863) for predicting incident CVD in a community-based, prospective study across seven geographic regions: South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa...
October 24, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29057897/alcohol-consumption-impairs-the-ependymal-cilia-motility-in-the-brain-ventricles
#18
Alzahra J Al Omran, Hannah C Saternos, Yusuf S Althobaiti, Alexander Wisner, Youssef Sari, Surya M Nauli, Wissam A AbouAlaiwi
Ependymal cilia protrude into the central canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF). Ependymal cilia dysfunction can hinder the movement of CSF leading to an abnormal accumulation of CSF within the brain known as hydrocephalus. Although the etiology of hydrocephalus was studied before, the effects of ethanol ingestion on ependymal cilia function have not been investigated in vivo. Here, we report three distinct types of ependymal cilia, type-I, type-II and type-III classified based upon their beating frequency, their beating angle, and their distinct localization within the mouse brain-lateral ventricle...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050384/stimulating-thought-a-functional-mri-study-of-transcranial-direct-current-stimulation-in-schizophrenia
#19
RANDOMIZED CONTROLLED TRIAL
Natasza D Orlov, Owen O'Daly, Derek K Tracy, Yusuf Daniju, John Hodsoll, Lorena Valdearenas, John Rothwell, Sukhi S Shergill
Individuals with schizophrenia typically suffer a range of cognitive deficits, including prominent deficits in working memory and executive function. These difficulties are strongly predictive of functional outcomes, but there is a paucity of effective therapeutic interventions targeting these deficits. Transcranial direct current stimulation is a novel neuromodulatory technique with emerging evidence of potential pro-cognitive effects; however, there is limited understanding of its mechanism. This was a double-blind randomized sham controlled pilot study of transcranial direct current stimulation on a working memory (n-back) and executive function (Stroop) task in 28 individuals with schizophrenia using functional magnetic resonance imaging...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28983674/contrast-enhanced-ultrasound-ceus-of-the-abdominal-vasculature
#20
REVIEW
Vasileios Rafailidis, Cheng Fang, Gibran T Yusuf, Dean Y Huang, Paul S Sidhu
Vascular diseases account for a significant proportion of abdominal pathology and represent a common referral source for abdominal ultrasonographic examinations. B-mode, color Doppler, and spectral Doppler analyses are well-established in the evaluation of abdominal blood vessels although they may occasionally be limited by lower sensitivity for slow flow visualization or the deeper location of abdominal vascular structures. The introduction of microbubbles as ultrasonographic contrast agents has rendered contrast-enhanced ultrasound (CEUS), a valuable complementary ultrasonographic technique, which is capable of addressing clinically significant problems and guiding patient management...
October 5, 2017: Abdominal Radiology
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