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https://www.readbyqxmd.com/read/29450615/contrast-enhanced-ultrasound-ceus-in-abdominal-intervention
#1
REVIEW
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Raymond Ramnarine, Annamaria Deganello, Maria E Sellars, Paul S Sidhu
The introduction of ultrasound contrast agents has rendered contrast-enhanced ultrasound (CEUS) a valuable complementary technique to address clinically significant problems. This pictorial review describes the use of CEUS guidance in abdominal intervention and illustrates such application for a range of clinical indications. Clinical application of CEUS discussed include commonly performed abdominal interventional procedures, such as biopsy, drainage, nephrostomy, biliary intervention, abdominal tumor ablation and its subsequent monitoring, and imaging of vascular complications following abdominal intervention...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29445102/reversal-of-stress-fibre-formation-by-nitric-oxide-mediated-rhoa-inhibition-leads-to-reduction-in-the-height-of-preformed-thrombi
#2
L Atkinson, M Z Yusuf, A Aburima, Y Ahmed, S G Thomas, K M Naseem, S D J Calaminus
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytoskeleton reversing platelet spreading, and therefore reduce the capability of thrombi to withstand a high shear environment. Our data demonstrates that GSNO, DEANONOate, and a PKG-activating cGMP analogue reversed stress fibre formation and increased actin nodule formation in adherent platelets...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29431256/heart-failure-with-mid-range-ejection-fraction-in-charm-characteristics-outcomes-and-effect-of-candesartan-across-the-entire-ejection-fraction-spectrum
#3
Lars H Lund, Brian Claggett, Jiankang Liu, Carolyn S Lam, Pardeep S Jhund, Giuseppe M Rosano, Karl Swedberg, Salim Yusuf, Christopher B Granger, Marc A Pfeffer, John J V McMurray, Scott D Solomon
AIMS: We tested the hypothesis that candesartan improves outcomes in heart failure (HF) with mid-range ejection fraction [HFmrEF; ejection fraction (EF) 40-49%]. METHODS AND RESULTS: In 7598 patients enrolled in the CHARM Programme (HF across the spectrum of EF), we assessed characteristics, outcomes and treatment effect of candesartan according to EF. Patients with HFmrEF (n = 1322, 17%) were similar to those with HF with reduced EF (HFrEF; n = 4323, 57%) with respect to some characteristics, and intermediate between HFrEF and HF with preserved EF (HFpEF; n = 1953, 26%) with respect to others...
February 12, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29401619/alkaline-ceramidase-2-is-essential-for-the-homeostasis-of-plasma-sphingoid-bases-and-their-phosphates
#4
Fang Li, Ruijuan Xu, Benjamin E Low, Chih-Li Lin, Monica Garcia-Barros, Jennifer Schrandt, Izolda Mileva, Ashley Snider, Catherine K Luo, Xian-Cheng Jiang, Ming-Song Li, Yusuf A Hannun, Lina M Obeid, Michael V Wiles, Cungui Mao
Sphingosine-1-phosphate (S1P) plays important roles in cardiovascular development and immunity. S1P is abundant in plasma because erythrocytes-the major source of S1P-lack any S1P-degrading activity; however, much remains unclear about the source of the plasma S1P precursor, sphingosine (SPH), derived mainly from the hydrolysis of ceramides by the action of ceramidases that are encoded by 5 distinct genes, acid ceramidase 1 ( ASAH1)/ Asah1, ASAH2/ Asah2, alkaline ceramidase 1 ( ACER1)/ Acer1, ACER2/ Acer2, and ACER3/ Acer3, in humans/mice...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29398173/design-of-a-randomized-placebo-controlled-trial-to-assess-dabigatran-and-omeprazole-in-patients-with-myocardial-injury-after-noncardiac-surgery-manage
#5
Emmanuelle Duceppe, Salim Yusuf, Vikas Tandon, Reitze Rodseth, Bruce M Biccard, Denis Xavier, Wojciech Szczeklik, Christian S Meyhoff, Maria Grazia Franzosi, Jessica Vincent, Sadeesh K Srinathan, Joel Parlow, Patrick Magloire, John Neary, Mangala Rao, Navneet K Chaudhry, Bongani Mayosi, Miriam de Nadal, Ekaterine Popova, Juan Carlos Villar, Fernando Botto, Otavio Berwanger, Gordon Guyatt, John W Eikelboom, Daniel I Sessler, Clive Kearon, Shirley Pettit, Stuart J Connolly, Mukul Sharma, Shrikant I Bangdiwala, P J Devereaux
BACKGROUND: Worldwide approximately 200 million adults undergo major surgery annually, of whom 8 million are estimated to suffer a myocardial injury after noncardiac surgery (MINS). There is currently no trial data informing the management of MINS. Antithrombotic agents such as direct oral anticoagulants might prevent major vascular complications in patients with MINS. METHODS: The Management of Myocardial Injury After Noncardiac Surgery (MANAGE) trial is a large international blinded randomized controlled trial of dabigatran vs placebo in patients who suffered MINS...
February 2, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29378996/cardiac-troponin-t-and-creatine-kinase-mb-fraction-levels-among-patients-with-acute-ischemic-stroke-in-nigeria
#6
H M Suleiman, I S Aliyu, S A Abubakar, M S Isa, J M El-Bashir, R Adamu, M Z Ibrahim, A Mohammed, R Yusuf, M Manu, A B Dogara, S K Mustapha, N Bello, S A Ozovehe
BACKGROUND: Stroke has been a global burden, with increasing morbidity and mortality. Serum cardiac troponin t (cTnT) and creatine kinase (CK-MB) fraction are reported to be elevated in patients admitted with acute ischaemic stroke and high level of these biomarkers indicated more severe stroke and neurologic deficit in some of the patients. OBJECTIVE: To evaluate the serum levels cardiac troponin t (cTnT) and creatine kinase MB fraction (CK-MB) in patients with acute ischaemic stroke and relate the analytes to severity of stroke...
December 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29350485/purification-of-glutathione-s-transferase-enzyme-from-quail-liver-tissue-and-inhibition-effects-of-3ar-4s-7r-7as-2-4-e-3-aryl-acryloyl-phenyl-3a-4-7-7a-tetrahydro-1h-4-7-methanoisoindole-1-3-2h-dione-derivatives-on-the-enzyme-activity
#7
Yusuf Temel, Umit M Koçyigit, M Şerif Taysı, Faik Gökalp, Meliha Burcu Gürdere, Yakup Budak, Mustafa Ceylan, İlhami Gülçin, Mehmet Çiftci
The use of quail meat and eggs has made this animal important in recent years, with its low cost and high yields. Glutathione S-transferases (GST, E.C.2.5.1.18) are an important enzyme family, which play a critical role in detoxification system. In our study, GST was purified from quail liver tissue with 47.88-fold purification and 12.33% recovery by glutathione agarose affinity chromatography. The purity of enzyme was checked by SDS-PAGE method and showed a single band. In addition, inhibition effects of (3aR,4S,7R,7aS)-2-(4-((E)-3-(aryl)acryloyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7methanoisoindole-1,3(2H)-dion derivatives (1a-g) were investigated on the enzyme activity...
January 19, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29333637/increased-free-zn2-correlates-induction-of-sarco-endo-plasmic-reticulum-stress-via-altered-expression-levels-of-zn2-transporters-in-heart-failure
#8
Yusuf Olgar, Aysegul Durak, Erkan Tuncay, Ceylan Verda Bitirim, Evren Ozcinar, Mustafa Bahadir Inan, Zeynep Tokcaer-Keskin, Kamil Can Akcali, Ahmet Ruchan Akar, Belma Turan
Zn2+ -homoeostasis including free Zn2+ ([Zn2+ ]i ) is regulated through Zn2+ -transporters and their comprehensive understanding may be important due to their contributions to cardiac dysfunction. Herein, we aimed to examine a possible role of Zn2+ -transporters in the development of heart failure (HF) via induction of ER stress. We first showed localizations of ZIP8, ZIP14 and ZnT8 to both sarcolemma and S(E)R in ventricular cardiomyocytes (H9c2 cells) using confocal together with calculated Pearson's coefficients...
January 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29330598/satisfaction-in-rhinoplasty-the-possible-impact-of-anxiety-and-functional-outcome
#9
Serap Koybasi, Yusuf Ozgur Bicer, Sinan Seyhan, Selcan Kesgin
BACKGROUND: Rhinoplasty is a complex but commonly applied surgical procedure. Patient satisfaction is the least discussed but one of the most important determinants of surgical success. OBJECTIVES: Evaluation of the patient satisfaction together with surgeon satisfaction were the main goals of this study. The roles of anxiety, gender, age and follow-up period were also studied. PATIENTS AND METHODS: 53 eligible patients operated by the first two authors within the previous 2 years were enrolled in the study...
January 12, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29326124/bortezomib-based-immunosuppression-after-reduced-intensity-conditioning-hematopoietic-stem-cell-transplantation-randomized-phase-ii-results
#10
John Koreth, Haesook T Kim, Paulina B Lange, Samuel J Poryanda, Carol G Reynolds, Sharmila Chamling Rai, Philippe Armand, Corey S Cutler, Vincent T Ho, Brett Glotzbecker, Rushdia Yusuf, Sarah Nikiforow, Yi-Bin Chen, Bimalangshu Dey, Malgorzata McMasters, Jerome Ritz, Bruce R Blazar, Robert J Soiffer, Joseph H Antin, Edwin P Alyea
A prior phase I/II trial of bortezomib/tacrolimus/methotrexate prophylaxis after HLA-mismatched reduced intensity conditioning allogeneic hematopoietic stem cell transplantation documented low acute graft versus host disease incidence, with promising overall and progression-free survival. We performed an open-label 3-arm 1:1:1 phase II randomized-controlled-trial comparing grade II-IV acute graft versus host disease between conventional tacrolimus/methotrexate (A) versus bortezomib/tacrolimus/methotrexate (B); and versus bortezomib/sirolimus/tacrolimus (C), in reduced intensity conditioning allogeneic transplantation recipients lacking HLA-matched related donors...
January 11, 2018: Haematologica
https://www.readbyqxmd.com/read/29314509/nanoparticles-formed-onto-into-halloysite-clay-tubules-architectural-synthesis-and-applications
#11
REVIEW
Vladimir A Vinokurov, Anna V Stavitskaya, Aleksandr P Glotov, Andrei A Novikov, Anna V Zolotukhina, Mikhail S Kotelev, Pawel A Gushchin, Evgenii V Ivanov, Yusuf Darrat, Yuri M Lvov
Nanoparticles, being objects with high surface area are prone to agglomeration. Immobilization onto solid supports is a promising method to increase their stability and it allows for scalable industrial applications, such as metal nanoparticles adsorbed to mesoporous ceramic carriers. Tubular nanoclay - halloysite - can be an efficient solid support, enabling the fast and practical architectural (inside / outside) synthesis of stable metal nanoparticles. The obtained halloysite-nanoparticle composites can be employed as advanced catalysts, ion-conducting membrane modifiers, inorganic pigments, and optical markers for biomedical studies...
January 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29303127/assessment-of-biochemical-liver-function-tests-in-relation-to-age-among-steady-state-sickle-cell-anemia-patients
#12
S A Akuyam, A Abubakar, N Lawal, R Yusuf, S M Aminu, A Hassan, A Musa, A K Bello, I A Yahaya, P A Okafor
BACKGROUND AND OBJECTIVE: Multiorgan failure including liver dysfunction is a common finding in sickle cell anemia (SCA) patients, the cause of which is multifactorial with advancing age said to be a major determinant. There is a paucity of data on liver function among SCA patients in relation to age in northern Nigerian hospitals, including Ahmadu Bello University Teaching Hospital (ABUTH), Zaria. This study was to assess the biochemical liver function tests (LFTs) as they relate to age among SCA patients in steady state, with a view to improving the overall monitoring of these patients...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29303106/recommendation-for-treatment-of-hepatitis-c-virus-infection
#13
Sabahattin Kaymakoğlu, İftihar Köksal, Fehmi Tabak, Ulus S Akarca, Ayhan Akbulut, Filiz Akyüz, Hürrem Bodur, Atahan Çağatay, Dinç Dinçer, Şaban Esen, Rahmet Güner, Selim Gürel, Şükran Köse, Ömer Şentürk, Halis Şimşek, Tansu Yamazhan, Yusuf Yılmaz, Ramazan Idilman, Viral Hepatitis Guidelines Study Group
No abstract text is available yet for this article.
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29295768/an-extremely-rare-but-considerably-important-device-related-complication-of-percutaneous-atrial-septal-defect-closure
#14
Yusuf I Alihanoglu, Dogu I Kilic, Bekir S Yildiz, Bilgin Emrecan, Harun Evrengul
No abstract text is available yet for this article.
December 30, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29275195/nitric-oxide-mediated-integrative-alterations-in-plant-metabolism-to-confer-abiotic-stress-tolerance-no-crosstalk-with-phytohormones-and-no-mediated-post-translational-modifications-in-modulating-diverse-plant-stress
#15
REVIEW
Fareen Sami, Mohammad Faizan, Ahmad Faraz, Husna Siddiqui, Mohammad Yusuf, Shamsul Hayat
Nitric oxide (NO) is a major signaling biomolecule associated with signal transduction in plants. The beneficial role of NO in plants, exposed to several abiotic stresses shifted our understanding as it being not only free radical, released from the toxic byproducts of oxidative metabolism but also helps in plant sustenance. An explosion of research in plant NO biology during the last two decades has revealed that NO is a key signal associated with plant growth, germination, photosynthesis, leaf senescence, pollen growth and reorientation...
December 21, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29273920/particulate-matter-concentration-levels-during-intense-haze-event-in-an-urban-environment
#16
Jamiu Adetayo Adeniran, Adeniyi Saheed Aremu, Yusuf Olatunji Saadu, Rafiu Olasunkanmi Yusuf
This study assessed concentration levels of particulate matter (PM) in the ambient environment of Ilorin metropolis, Nigeria, during haze episodes. Meteorological data (wind speed and direction, rainfall data, sunshine data, relative humidity and temperature) were obtained. Aerocet 531S particle counter (MetOne Instruments, USA) was used to measure four mass concentration ranges of PM (PM1.0, PM2.5, PM10 and the total suspended particles (TSP)) in 10 locations taking into consideration land use patterns. Surfer® version 8 (Golden Software LLC, USA) was used to model the spatial variation of particulate matter concentration levels using kriging interpolation griding method...
December 22, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29259659/pregnancy-related-conditions-and-premature-coronary-heart-disease-in-adult-offspring
#17
Andriany Qanitha, Bastianus A J M de Mol, David P Burgner, Peter Kabo, Dara R Pabittei, Irawan Yusuf, Cuno S P M Uiterwaal
Objective: To investigate the association between complications during pregnancy and premature coronary heart disease in adult offspring. Methods: We conducted a population-based case-control study of 153 Indonesian patients with a first acute coronary syndrome (ACS) (age ≤55 years) and 153 age-matched and sex-matched controls. Data on complications during pregnancy (high blood pressure, preterm delivery) and maternal infections in pregnancy were obtained, together with sociodemographic data, clinical profiles, laboratory measurements and adulthood cardiovascular disease (CVD) risk factors at hospital admission or enrolment...
2017: Heart Asia
https://www.readbyqxmd.com/read/29259036/loss-of-acid-ceramidase-in-myeloid-cells-suppresses-intestinal-neutrophil-recruitment
#18
Mel Pilar Espaillat, Ashley J Snider, Zhijuan Qiu, Breana Channer, Nicolas Coant, Edward H Schuchman, Richard R Kew, Brian S Sheridan, Yusuf A Hannun, Lina M Obeid
Bioactive sphingolipids are modulators of immune processes and their metabolism is often dysregulated in ulcerative colitis, a major category of inflammatory bowel disease (IBD). While multiple axes of sphingolipid metabolism have been investigated to delineate mechanisms regulating ulcerative colitis, the role of acid ceramidase (AC) in intestinal inflammation is yet to be characterized. Here we demonstrate that AC expression is elevated selectively in the inflammatory infiltrate in human and murine colitis...
December 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29258214/extraction-and-analysis-of-respiratory-motion-using-wearable-inertial-sensor-system-during-trunk-motion
#19
Apoorva Gaidhani, Kee S Moon, Yusuf Ozturk, Sung Q Lee, Woosub Youm
Respiratory activity is an essential vital sign of life that can indicate changes in typical breathing patterns and irregular body functions such as asthma and panic attacks. Many times, there is a need to monitor breathing activity while performing day-to-day functions such as standing, bending, trunk stretching or during yoga exercises. A single IMU (inertial measurement unit) can be used in measuring respiratory motion; however, breathing motion data may be influenced by a body trunk movement that occurs while recording respiratory activity...
December 17, 2017: Sensors
https://www.readbyqxmd.com/read/29220676/penetrance-of-polygenic-obesity-susceptibility-loci-across-the-body-mass-index-distribution
#20
Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C Engert, Salim Yusuf, Hertzel C Gerstein, Sonia S Anand, David Meyre
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%)-rs1421085 (FTO; p = 8.69 × 10-15), rs6235 (PCSK1; p = 7...
December 7, 2017: American Journal of Human Genetics
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