keyword
MENU ▼
Read by QxMD icon Read
search

sepsis macrophage

keyword
https://www.readbyqxmd.com/read/28230708/cell-derived-nanoparticles-are-endogenous-modulators-of-sepsis-with-therapeutic-potential
#1
Natalia Kunz, Brent T Xia, Kai-Uwe Kalies, Matthias Klinger, Timo Gemoll, Jens K Habermann, Brynne E Whitacre, Aaron P Seitz, Kathrin Kalies, Charles C Caldwell
Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated from stressed eukaryotic cells. Previously, CDNPs isolated from cultured cells exerted immunomodulatory activities in different infections. Here, we sought to elucidate the role of CDNPs using a murine model of cecal ligation and puncture (CLP). We hypothesized that CDNPs influence the immune response at the site of infection, where severe cellular stress occurs. We observed early CDNP accumulation in the peritoneum after 4 h and continued CDNP presence 24 h after CLP...
February 22, 2017: Shock
https://www.readbyqxmd.com/read/28216261/modulating-the-function-of-the-immune-system-by-thyroid-hormones-and-thyrotropin
#2
REVIEW
Evelyn L Jara, Natalia Muñoz-Durango, Carolina Llanos, Carlos Fardella, Pablo A González, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel
Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections...
February 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28212865/casein-kinase-2-interacting-protein-1-regulates-m1-and-m2-inflammatory-macrophage-polarization
#3
Yuhan Chen, Wen Liu, Yiwu Wang, Luo Zhang, Jun Wei, Xueli Zhang, Fuchu He, Lingqiang Zhang
The importance of macrophage plasticity, albeit being discovered recently, has been highlighted in a broad spectrum of biological processes operative in physiological and pathological environments. Macrophage polarized activation and inactivation has profound effects on immune and inflammatory responses with several major pathways being elucidated in the past few years. However, transcriptional regulation mechanisms governing macrophage polarization is still preliminary. In this study, we identify the Casein Kinase 2 Interacting Protein 1 (CKIP-1) as a molecular toggle manipulating macrophage speciation...
February 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28209713/mir-718-represses-pro-inflammatory-cytokine-production-through-targeting-pten
#4
Parisa Kalantari, Omid F Harandi, Sarika Agarwal, Florentina Rus, Evelyn A Kurt-Jones, Katherine A Fitzgerald, Daniel R Caffrey, Douglas T Golenbock
Bacterial sepsis involves a complex interaction between the host immune response and bacterial lipopolysaccharides (LPS). LPS binds Toll-like receptor (TLR) 4, which leads to the release of pro-inflammatory cytokines that are essential for a potent innate immune response against pathogens. The innate immune system is tightly regulated as excessive inflammation can lead to organ failure and death. MicroRNAs have recently emerged as important regulators of the innate immune system. Here, we determined the function of miR-718, which is conserved across mammals and overlaps with the 5 UTR of the Interleukin-1 Receptor-Associated Kinase (IRAK1) gene...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28203237/activation-of-the-wnt-pathway-by-mycobacterium-tuberculosis-a-wnt-wnt-situation
#5
REVIEW
Tomás Villaseñor, Edgardo Madrid-Paulino, Rafael Maldonado-Bravo, Antonio Urbán-Aragón, Leonor Pérez-Martínez, Gustavo Pedraza-Alva
Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of tuberculosis (TB), a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors expressed on the host innate immune cells, including Toll-like receptors, Nod-like receptors, and C-type lectin receptors like Dectin-1, the Mannose receptor, and DC-SIGN...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28203235/chenopodium-ambrosioides-l-improves-phagocytic-activity-and-decreases-bacterial-growth-and-the-systemic-inflammatory-response-in-sepsis-induced-by-cecal-ligation-and-puncture
#6
Carlos E P Rios, Afonso G Abreu, Jose A F Braga Filho, Johnny R Nascimento, Rosane N M Guerra, Flávia M M Amaral, Márcia C G Maciel, Flávia R F Nascimento
Chenopodium ambrosioides L. (Amaranthaceae) is often used in different kinds of vegetal preparations for medicinal purposes in many clinical situations. Some studies have demonstrated its anti-inflammatory and immunomodulatory properties. The aim of this work was to investigate the effect of prophylactic treatment with the hydroalcoholic crude extract (HCE) of C. ambrosioides and its hexanic fraction (HEX) on the control of bacterial growth, the activation of phagocytes and the control of the systemic inflammatory response in a sepsis experimental model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28189043/type-i-interferon-signalling-is-not-required-for-the-induction-of-endotoxin-tolerance
#7
Yalda Karimi, Sophie M Poznanski, Fatemeh Vahedi, Branson Chen, Marianne V Chew, Amanda J Lee, Ali A Ashkar
Endotoxin, or LPS tolerance, is an immunomodulatory mechanism that results in a significantly diminished response to secondary LPS exposure, which may serve to protect the host against endotoxic shock. Type I interferons (IFNs) are cytokines released upon LPS binding to TLR4 and have been shown to have immunomodulatory properties. Due to this regulatory function of type I IFN, we aimed to investigate the role of type I IFN signalling in LPS tolerance. Our data suggests that type I IFN does not play a role in LPS tolerance in vitro, as both wild type and IFNAR1(-/-) peritoneal macrophages showed reduced cytokine production after secondary LPS exposure...
February 8, 2017: Cytokine
https://www.readbyqxmd.com/read/28179905/plasma-levels-of-macrophage-migration-inhibitory-factor-and-d-dopachrome-tautomerase-show-a-highly-specific-profile-in-early-life
#8
Thierry Roger, Luregn J Schlapbach, Anina Schneider, Manuela Weier, Sven Wellmann, Patrick Marquis, David Vermijlen, Fred C G J Sweep, Lin Leng, Richard Bucala, Thierry Calandra, Eric Giannoni
Macrophage migration inhibitory factor (MIF) is a pleiotropic, constitutively expressed, pro-inflammatory cytokine and an important regulator of immune responses. d-dopachrome tautomerase (DDT), a newly described member of the MIF protein superfamily, shares sequence homology and biological activities with MIF. We recently reported that high expression levels of MIF sustain innate immune responses in newborns. Here, we elected to further characterize age-dependent MIF expression and to define whether DDT shares a similar expression profile with MIF...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28178007/role-of-skin-biopsies-in-the-diagnosis-of-hemophagocytic-lymphohistiocytosis
#9
Aileen Santos-Arroyo, Julián Barrera-Llaurador, Julio E Sánchez, Rafael Martín-García, Jorge L Sánchez
This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition...
January 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28165033/micheliolide-provides-protection-of-mice-against-staphylococcus-aureus-and-mrsa-infection-by-down-regulating-inflammatory-response
#10
Xinru Jiang, Yuli Wang, Yifei Qin, Weigang He, Adel Benlahrech, Qingwen Zhang, Xin Jiang, Zhenhui Lu, Guang Ji, Yuejuan Zheng
A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G(+)) bacteria, most commonly staphylococci, are thought to be the main pathogens. Micheliolide (MCL) was demonstrated to provide a therapeutic role in rheumatoid arthritis, inflammatory intestinal disease, colitis-associated cancer, and lipopolysaccharide (LPS, the main component of G(-) bacterial cell wall) induced septic shock. We proved here that MCL played an anti-inflammatory role in Staphylococcus aureus (S...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28153725/differences-in-the-effects-of-four-trpv1-channel-antagonists-on-lipopolysaccharide-induced-cytokine-production-and-cox-2-expression-in-murine-macrophages
#11
Yuki Ninomiya, Sei-Ichi Tanuma, Mitsutoshi Tsukimoto
Sepsis is a systemic inflammatory response syndrome triggered by lipopolysaccharide (LPS), an outer membrane component of gram-negative bacteria, and cytokine production via LPS-induced macrophage activation is deeply involved in its pathogenesis. Effective therapy of sepsis has not yet been established. However, it was reported that transient receptor potential vanilloid 1 (TRPV1) channel antagonist capsazepine (CPZ; a capsaicin analogue) attenuates sepsis in a murine model [Ang et al., PLoS ONE 6(9) (2011) e24535; J...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28152394/dnaj-hsp40-of-streptococcus-pneumoniae-is-involved-in-bacterial-virulence-and-elicits-a-strong-natural-immune-reaction-via-pi3k-jnk
#12
Jin Cui, Chenyu Ma, Guo Ye, Yong Shi, Wenchun Xu, Liang Zhong, Jian Wang, Yibing Yin, Xuemei Zhang, Hong Wang
As a heat shock protein, DnaJ plays an important role in the pathogenesis of pneumococcal infection. However, how the virulence factor-DnaJ elicits host natural immunity still remains unclear. In this study, we investigated the effects of dnaJ deficiency in Streptococcus pneumoniae (S. pneumoniae) on bacterial virulence, and further explored the related molecular mechanisms in vivo and in vitro. By generating dnaJ deficient mutant (ΔdnaJ), the virulence and colonization were detected in murine pneumonia and sepsis models in vivo...
March 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28149024/extremely-high-ferritinemia-associated-with-haemophagocytic-lympho-histiocytosis-hlh
#13
Neelima Verma, Jyoti Chakraverty, Pankaj Baweja, Alka Girotra, Leena Chatterjee, Manish Chugh
Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28145460/caffeic-acid-cyclohexylamide-rescues-lethal-inflammation-in-septic-mice-through-inhibition-of-i%C3%AE%C2%BAb-kinase-in-innate-immune-process
#14
Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung, Won-Jea Cho, Byeongwoo Ahn, Cheong-Yong Yun, Yong Pyo Choi, Jong Hun Yeo, Heesoon Lee, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim
Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a molecular target of caffeic acid cyclohexylamide (CGA-JK3) in the treatment of polymicrobial TLR agonists-induced lethal inflammation. CGA-JK3 ameliorated E. coli lipopolysaccharide (LPS, MD-2/TLR4 agonist)-induced endotoxic shock, cecal ligation and puncture (CLP)-challenged septic shock or LPS plus D-galactosamine (GalN)-induced acute liver failure (ALF) in C57BL/6J mice...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134560/chloroquine-attenuates-lipopolysaccharide-induced-inflammatory-responses-through-upregulation-of-usp25
#15
Changyu Ding, Fangfang Li, Yupeng Long, Jiang Zheng
Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 colocalization and inhibit both MyD88-dependent and TRAM/TRIF-dependent pathways, though the mechanism involved is still poorly understood. Here, we found that the ubiquitin-proteasome system might be involved in this process...
November 30, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28125526/mir-155-alleviates-septic-lung-injury-by-inducing-autophagy-via-inhibition-of-transforming-growth-factor-%C3%AE-activated-binding-protein-2
#16
Fen Liu, Cheng Nie, Ning Zhao, Yan Wang, Yang Liu, Yong Li, Zhenguo Zeng, Chengzhi Ding, Qiang Shao, Cheng Qing, Liang Xia, Zhiyong Peng, Kejian Qian
BACKGROUND: The anti-inflammatory effect of miR-155 was closely linked to transforming growth factor-β-activated kinase-1-binding protein 2 (TAB2) and autophagy. This study investigated the role of miR-155 in attenuation of septic lung injury through TAB2 and autophagy in mouse model and in vitro. METHODS: Patients who underwent fiberoptic bronchoscope examination with or without septic lung injury were recruited for collection of bronchoalveolar lavage fluid (BALF) samples...
January 25, 2017: Shock
https://www.readbyqxmd.com/read/28120605/hemophagocytic-lymphohistiocytosis-mimics-many-common-conditions-case-series-and-review-of-literature
#17
A T Akenroye, N Madan, F Mohammadi, J Leider
Introduction. Hemophagocytic lymphohistiocytosis (HLH), a rare but potentially fatal disease, is characterized by excessive immune activation and cytokine release which stimulates bone marrow macrophages to engulf hematopoietic cells. HLH could be secondary to infections: viral, fungal, and bacterial; malignancies and autoimmune diseases. The diagnosis of HLH is usually delayed due to the presence of non-specific symptoms at presentation. This delay contributes to increased mortality. Cases and review. We present the case of 4 patients who presented with subjective fevers and extreme fatigue...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28112185/lyrm03-an-ubenimex-derivative-attenuates-lps-induced-acute-lung-injury-in-mice-by-suppressing-the-tlr-4-signaling-pathway
#18
Hui-Qiong He, Ya-Xian Wu, Yun-Juan Nie, Jun Wang, Mei Ge, Feng Qian
Toll-like receptor 4 (TLR4)-mediated signaling plays a critical role in sepsis-induced acute lung injury (ALI). LYRM03 (3-amino-2-hydroxy-4-phenyl-valyl-isoleucine) is a novel derivative of ubenimex, a widely used antineoplastic medicine. We previously found that LYRM03 has anti-inflammatory effects in cecal ligation puncture mouse model. In this study we determined whether LYRM03 attenuated LPS-induced ALI in mice. LPS-induced ALI mouse model was established by challenging the mice with intratracheal injection of LPS (5 mg/kg), which was subsequently treated with LYRM03 (10 mg/kg, ip)...
January 23, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28111134/aldose-reductase-akr1b-deficiency-promotes-phagocytosis-in-bone-marrow-derived-mouse-macrophages
#19
Mahavir Singh, Aniruddh Kapoor, James McCracken, Bradford Hill, Aruni Bhatnagar
Macrophages are critical drivers of the immune response during infection and inflammation. The pathogenesis of several inflammatory conditions, such as diabetes, cancer and sepsis has been linked with aldose reductase (AR), a member of the aldo-keto reductase (AKR) superfamily. However, the role of AR in the early stages of innate immunity such as phagocytosis remains unclear. In this study, we examined the role of AR in regulating the growth and the phagocytic activity of bone marrow-derived mouse macrophages (BMMs) from AR-null and wild-type (WT) mice...
January 19, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28108420/neutrophil-derived-microparticles-increase-mortality-and-the-counter-inflammatory-response-in-a-murine-model-of-sepsis
#20
Bobby L Johnson, Emily F Midura, Priya S Prakash, Teresa C Rice, Natalia Kunz, Kathrin Kalies, Charles C Caldwell
Although advances in medical care have significantly improved sepsis survival, sepsis remains the leading cause of death in the ICU. This is likely due to a lack of complete understanding of the pathophysiologic mechanisms that lead to dysfunctional immunity. Neutrophil derived microparticles (NDMPs) have been shown to be the predominant microparticle present at infectious and inflamed foci in human models, however their effect on the immune response to inflammation and infection is sepsis has not been fully elucidated...
January 17, 2017: Biochimica et Biophysica Acta
keyword
keyword
120656
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"