keyword
MENU ▼
Read by QxMD icon Read
search

sepsis macrophage

keyword
https://www.readbyqxmd.com/read/29673286/inhibition-of-autophagy-with-3-methyladenine-is-protective-in-a-lethal-model-of-murine-endotoxemia-and-polymicrobial-sepsis
#1
Qirui Li, Lingyun Li, Xiaoyuan Fei, Yuanyue Zhang, Chang Qi, Shuyao Hua, Feili Gong, Min Fang
Here, the regulatory role of autophagy is examined in both an LPS-induced lethal endotoxic shock mouse model and cecal ligation and puncture (CLP) mouse model. Autophagy-inhibitor 3-methyladenine (3-MA) and autophagy-enhancer rapamycin were administrated to mice challenged with LPS or CLP. Animals challenged with LPS or CLP combined with 3-MA displayed increased survival after endotoxemia, but LPS combined with rapamycin worsened the endotoxic shock of the mice. Among the different organs studied, the lungs and intestines exhibited significant differences among LPS alone, LPS combined with 3-MA and LPS combined with rapamycin...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29669785/-mycobacterium-tuberculosis-ppe18-protein-reduces-inflammation-and-increases-survival-in-animal-model-of-sepsis
#2
Asma Ahmed, Komal Dolasia, Sangita Mukhopadhyay
Mycobacterium tuberculosis PPE18 is a member of the PPE family. Previous studies have shown that recombinant PPE18 (rPPE18) protein binds to TLR2 and triggers a signaling cascade which reduces levels of TNF-α and IL-12, and increases IL-10 in macrophages. Because TNF-α is a major mediator of the pathophysiology of sepsis and blocking inflammation is a possible line of therapy in such circumstances, we tested the efficacy of rPPE18 in reducing symptoms of sepsis in a mouse model of Escherichia coli- induced septic peritonitis...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29668526/immunophenotyping-of-monocytes-during-human-sepsis-shows-impairment-in-antigen-presentation-a-shift-toward-nonclassical-differentiation-and-upregulation-of-fc%C3%AE-ri-receptor
#3
Nadijane Valeria Ferreira da Mota, Milena Karina Colo Brunialti, Sidneia Sousa Santos, Flavia Ribeiro Machado, Murillo Assunçao, Luciano Cesar Pontes de Azevedo, Reinaldo Salomao
Monocytes and macrophages are pivotal in the host response to sepsis, recognizing the infecting microorganism and triggering an inflammatory response. These functions are, at least in part, modulated by the expression of cell surface receptors. We aimed to characterize the monocyte phenotype from septic patients during an ongoing sepsis process and its association with clinical outcomes. Sixty-one septic patients and 31 healthy volunteers (HVs) were enrolled in the study. Samples were obtained from patients at baseline (D0, N = 61), and after 7 (D7, N = 36) and 14 days of therapy (D14, N = 22)...
December 5, 2017: Shock
https://www.readbyqxmd.com/read/29666944/macrophages-play-an-essential-role-in-trauma-induced-sterile-inflammation-and-tissue-repair
#4
REVIEW
Moritz Peiseler, Paul Kubes
Severe trauma is accompanied by a profound activation of the immune system. Patients with polytrauma develop systemic inflammatory response syndrome (SIRS) and often sepsis, which contributes substantially to high mortality of this condition. On a cellular level, necrosis and loss of plasma membrane integrity lead to the release of endogenous "damage-associated molecular patterns" (DAMPs) as danger signals, which in turn activate innate immune cells. Inflammation that occurs in the absence of invading pathogens has been termed sterile inflammation and trauma with tissue damage represents an acute form of sterile inflammation...
April 17, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29664835/phagocytosis-by-fibrocytes-as-a-mechanism-to-decrease-bacterial-burden-and-increase-survival-in-sepsis
#5
Dalis Collins, Christopher Fry, Bethany B Moore, Jean A Nemzek
Fibrocytes are unique cells with innate and adaptive immune functions, but these mechanisms have not been fully explored. The aim of this study was to explain the mechanism by which adoptive transfer of exogenous fibrocytes improved bacterial clearance and increased sepsis survival. Initial flow cytometry-based, in vitro assays demonstrated phagocytosis by fibrocytes and intracellular bacterial killing was confirmed by direct plating of cell lysates after exposure to live bacteria. Intravenous adoptive transfer of fibrocytes at the time of cecal ligation and puncture (CLP) or two hours after CLP in mice increased survivability...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29662129/intracellular-replication-of-streptococcus-pneumoniae-inside-splenic-macrophages-serves-as-a-reservoir-for-septicaemia
#6
Giuseppe Ercoli, Vitor E Fernandes, Wen Y Chung, Joseph J Wanford, Sarah Thomson, Christopher D Bayliss, Kornelis Straatman, Paul R Crocker, Ashley Dennison, Luisa Martinez-Pomares, Peter W Andrew, E Richard Moxon, Marco R Oggioni
Bacterial septicaemia is a major cause of mortality, but its pathogenesis remains poorly understood. In experimental pneumococcal murine intravenous infection, an initial reduction of bacteria in the blood is followed hours later by a fatal septicaemia. These events represent a population bottleneck driven by efficient clearance of pneumococci by splenic macrophages and neutrophils, but as we show in this study, accompanied by occasional intracellular replication of bacteria that are taken up by a subset of CD169+ splenic macrophages...
April 16, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29661910/myeloid-cell-deficiency-of-p38%C3%AE-p38%C3%AE-protects-against-candidiasis-and-regulates-antifungal-immunity
#7
Dayanira Alsina-Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González-Romero, Ester Díaz-Mora, Ana Risco, Miguel A Martín-Serrano, Carlos Del Fresno, Jorge Dominguez-Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz-Ezquerro, Ana Cuenda
Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. albicans We describe a new TAK1-TPL2-MKK1-ERK1/2 pathway in macrophages, which is activated by Dectin-1 engagement and positively regulated by p38γ/p38δ. In mice, p38γ/p38δ deficiency protects against C...
April 16, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29658572/pkr-inhibition-mediates-endotoxin-tolerance-in-macrophages-through-inactivation-of-pi3k-akt-signaling
#8
Hailin Xu, Juan Chen, Xiang Si, Minying Chen, Fei Pei, Chunfang Qiu, Jianfeng Wu, Xiangdong Guan
Following long‑term exposure to endotoxins, macrophages enter an immunosuppressive state that renders them unable respond to subsequent exposures to endotoxin, a phenomenon that is termed 'endotoxin tolerance'. Endotoxin tolerance increases the risks of secondary infection and mortality in patients with sepsis. In endotoxin‑tolerant macrophages, the mixed variation of gene transcription is referred to as macrophage reprogramming. The mechanisms underlying macrophage reprogramming remain unclear at present...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29644918/assessment-of-clinical-sepsis-associated-biomarkers-in-a-septic-mouse-model
#9
Jin-Ling Li, Ge Li, Xi-Zhong Jing, Yun-Feng Li, Qiu-Ying Ye, Huan-Huan Jia, Shu-Hua Liu, Xue-Jiao Li, Hang Li, Ren Huang, Yu Zhang, Hui Wang
Objective Clinical sepsis-associated biomarkers were utilized in a cecal ligation and puncture (CLP) septic mouse model to provide a reference for investigating pathophysiological mechanisms and evaluating novel therapeutic interventions for sepsis. Methods Sepsis in mice was induced by CLP, and clinical biomarkers were evaluated (survival rate, blood physiological and biochemical indices, cytokines, hepatorenal function parameters, and blood coagulation). Results The mortality rate was >70%. The body temperature, blood pressure, and heart rate decreased within 48 h...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29625385/targeting-macrophage-immunometabolism-dawn-in-the-darkness-of-sepsis
#10
REVIEW
V Kumar
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates. Advancement in modern medicine and establishment of separate branches of medical science dealing with sepsis research have improved its outcome. However, mortality associated with sepsis still remains higher (25-30%) that further increases to 40-50% in the presence of septic shock. For example, sepsis-associated deaths account more in comparison to deaths-associated with myocardial-infarction and certain cancers (i.e. breast and colorectal cancer)...
April 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29621118/bone-marrow-cells-transplant-in-septic-mice-modulates-systemic-inflammatory-response-via-cell-cell-contact
#11
Clara Batista Lorigados, Suely K Kubo Ariga, Thais Martins de Lima, Denise Frediane Barbeiro, Jose Eduardo Krieger, Francisco Garcia Soriano
Sepsis is a dynamic disease, displaying an inflammatory profile that varies over time and for each organ. Controlling the inflammatory response based in targeting a single molecule has been proved useless. We hypothesized that treatment with bone marrow derived mononuclear cells (BMDMC) may be more efficient to modulate the systemic inflammatory response to infection. Adult male Balb/c mice were subjected to cecal ligation and puncture (CLP) or endotoxemia model of experimental sepsis. BMDMC were separated under Ficoll gradient and injected intravenously 1 hour after the procedures...
April 4, 2018: Shock
https://www.readbyqxmd.com/read/29620575/sphingosine-1-phosphate-receptor-2-signaling-promotes-caspase-11-dependent-macrophage-pyroptosis-and-worsens-escherichia-coli-sepsis-outcome
#12
Fang Song, Jinchao Hou, Zhecong Chen, Baoli Cheng, Ruyi Lei, Ping Cui, Yaqi Sun, Haihong Wang, Xiangming Fang
BACKGROUND: Pyroptosis, a type of proinflammatory programmed cell death, drives cytokine storm. Caspase-11-dependent macrophage pyroptosis contributes to mortality during sepsis. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling can amplify interleukin-1β secretion in endotoxin-induced inflammation. Here, we hypothesized that S1PR2 signaling increases caspase-11-dependent macrophage pyroptosis and worsens Gram-negative sepsis outcome. METHODS: A Gram-negative sepsis model was induced through intraperitoneal injection of Escherichia coli...
April 3, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29608552/gts-21-reduces-inflammation-in-acute-lung-injury-by-regulating-m1-polarization-and-function-of-alveolar-macrophages
#13
Jing Wang, Ruiting Li, Zhiyong Peng, Wenhai Zhou, Bo Hu, Xin Rao, Xiao Yang, Jianguo Li
BACKGROUND: Acute lung injury (ALI) is a severe outcome of sepsis. Alveolar macrophages (AMs) play key roles in defense, resolution in ALI. The polarization of AMs is dependent on micro environmental stimuli and might influence the progression of ALI. GTS-21, a selective α7 nicotinic acetylcholine receptor agonist of the cholinergic anti-inflammatory pathway (CAP), has recently been established to be promising in the treatment of ALI. However, the molecular mechanism underlying the GTS-21-mediated suppression of inflammatory responses has been explored only partially...
March 30, 2018: Shock
https://www.readbyqxmd.com/read/29608550/amitriptyline-treatment-mitigates-sepsis-induced-tumor-necrosis-factor-expression-and-coagulopathy
#14
Brent T Xia, Nadine Beckmann, Leah K Winer, Young Kim, Holly S Goetzman, Rosalie E Veile, Erich Gulbins, Michael D Goodman, Vanessa Nomellini, Charles C Caldwell
During sepsis, the early innate response and inflammatory cytokine cascade are associated with activation of the coagulation cascade. Acute hypercoagulability can contribute to lethal sequela of vascular thrombosis, tissue ischemia, and organ failure. We investigated if amitriptyline (AMIT), an antidepressant drug with a number of anti-inflammatory effects, could ameliorate sepsis in a murine model of sepsis - cecal ligation and puncture (CLP). We hypothesized that AMIT treatment would reduce inflammation and mitigate sepsis-induced coagulopathy...
March 30, 2018: Shock
https://www.readbyqxmd.com/read/29601323/early-phase-innate-immune-suppression-in-murine-severe-sepsis-is-restored-with-systemic-interferon-%C3%AE
#15
Yoshiomi Kusakabe, Kanji Uchida, Yoshiro Yamamura, Takahiro Hiruma, Tokie Totsu, Yuho Tamai, Hitoshi Tsuyuzaki, Kyoko Hasegawa, Kyungho Chang, Yoshitsugu Yamada
BACKGROUND: Sepsis is a leading cause of death in the intensive care unit. Immune modulatory therapy targeting sepsis-associated proinflammatory responses has not shown survival benefit. Here, the authors evaluated innate immunity at the early stage of murine mild or severe peritoneal sepsis induced by cecal ligation and puncture, and the effect of systemic interferon-β, a potent inflammatory mediator, on severe sepsis as well as its mechanism of action. METHODS: Mild and severe sepsis was induced in C57BL/6 mice by cecal ligation and puncture with 22- and 18-gauge needles for puncture, respectively...
March 30, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29599924/asiatic-acid-attenuates-lipopolysaccharide-induced-injury-by-suppressing-activation-of-the-notch-signaling-pathway
#16
Xiong Yuyun, Cheng Xi, Yin Qing, Xia Lin, Rui Ke, Sun Bingwei
Sepsis is a severe multisystem disease with high mortality rates and limited treatment options. However, advances during the last decade have opened opportunities to develop novel therapeutic strategies. The Notch signaling pathway plays a critical role in inflammation, and its inhibition offers an avenue to treat inflammatory diseases, such as sepsis. Asiatic acid (AA), a triterpenoid isolated from Centella asiatica, reportedly exerts anti-oxidant, anti-tumor, and anti-inflammatory effects, but its mechanisms remain unclear...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29599918/fc-99-ameliorates-sepsis-induced-liver-dysfunction-by-modulating-monocyte-macrophage-differentiation-via-let-7a-related-monocytes-apoptosis
#17
Yarong Zhao, Haiyan Zhu, Haining Wang, Liang Ding, Lizhi Xu, Dai Chen, Sunan Shen, Yayi Hou, Huan Dou
Background: The liver is a vital target for sepsis-related injury, leading to inflammatory pathogenesis, multiple organ dysfunction and high mortality rates. Monocyte-derived macrophage transformations are key events in hepatic inflammation. N1 -[(4-methoxy)methyl]-4-methyl-1,2-benzenediamine (FC-99) previously displayed therapeutic potential on experimental sepsis. However, the underlying mechanism of this protective effect is still not clear. Results: FC-99 treatment attenuated the liver dysfunction in septic mice that was accompanied with reduced numbers of pro-inflammatory Ly6Chi monocytes in the peripheral blood and CD11b+ F4/80lo monocyte-derived macrophages in the liver...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29593238/three-hcp-homologs-with-divergent-extended-loop-regions-exhibit-different-functions-in-avian-pathogenic-escherichia-coli
#18
Jiale Ma, Min Sun, Zihao Pan, Wenchao Song, Chengping Lu, Huochun Yao
Type VI secretion systems (T6SSs) contribute to the pathogenicity of avian pathogenic Escherichia coli (APEC), one of the leading causative agents of sepsis and meningitis in poultry. The Hcp protein is a core component of the T6SS tail tube and acts as an exported receptor and a chaperone of effectors. In this study, four distinct Hcp types (Ia, Ib, IIa, and IIb) were designated in Gram-negative bacteria, three of which were widely distributed in APEC. We detected divergence in transcription levels among three hcp clusters in 50% duck serum and demonstrated that hcp1 was upregulated by relieving Fur repression...
March 29, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29587748/regulation-of-alveolar-macrophage-death-in-acute-lung-inflammation
#19
REVIEW
Erica K Y Fan, Jie Fan
Acute lung injury (ALI) and its severe form, known as acute respiratory distress syndrome (ARDS), are caused by direct pulmonary insults and indirect systemic inflammatory responses that result from conditions such as sepsis, trauma, and major surgery. The reciprocal influences between pulmonary and systemic inflammation augments the inflammatory process in the lung and promotes the development of ALI. Emerging evidence has revealed that alveolar macrophage (AM) death plays important roles in the progression of lung inflammation through its influence on other immune cell populations in the lung...
March 27, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29576323/immunomodulatory-treatment-with-systemic-gm-csf-augments-pulmonary-immune-responses-and-improves-neurological-outcome-after-experimental-stroke
#20
Claudia Dames, Katarzyna Winek, Yasmin Beckers, Odilo Engel, Andreas Meisel, Christian Meisel
Stroke-induced immunodepression is an independent risk factor for stroke-associated pneumonia (SAP). Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. However, whether GM-CSF restores immune function after stroke preventing SAP and improving outcome is unknown. Here, we demonstrated that GM-CSF treatment improved peripheral and pulmonary leukocyte numbers, peripheral cytokine responses, lowered lung bacterial burden in the early course and improved long-term functional outcome after experimental stroke...
March 9, 2018: Journal of Neuroimmunology
keyword
keyword
120656
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"