Camille Cohen, Séverine Coulon, Kanit Bhukhai, Antoine Neuraz, Michael Dussiot, Guillemette Fouquet, Marie-Bénédicte Le Stang, Martin Flamant, François Vrtovsnik, Aurélie Hummel, Bertrand Knebelmann, Laurent Mesnard, Eric Rondeau, Thiago T Maciel, Fabrizia Favale, Nicole Casadevall, Thao Nguyen-Khoa, Stéphane Moutereau, Christophe Legendre, Marc Benhamou, Renato C Monteiro, Olivier Hermine, Khalil El Karoui, Ivan C Moura
BACKGROUND: Erythrocytosis is a hematological disorder usually related to hematopoietic stem cell somatic mutations. However, unexplained erythrocytosis remains frequent. In this study, we evaluated the involvement of IgA1, a regulator of erythropoiesis also implicated in IgA nephropathy (IgAN) pathophysiology, in unexplained polycythemia/erythrocytosis (PE) of IgAN patients. METHODS: IgAN-PE patients' serum was collected, analyzed and used to study IgA1 effect on proliferation and differentiation of erythroid progenitors...
January 2022: EBioMedicine