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https://www.readbyqxmd.com/read/28819889/visualization-of-57-fe-labeled-heme-isotopic-fine-structure-and-localization-of-regions-of-erythroblast-maturation-in-mouse-spleen-by-maldi-fticr-ms-imaging
#1
Makoto Kihara, Yukari Matsuo-Tezuka, Mariko Noguchi-Sasaki, Keigo Yorozu, Mitsue Kurasawa, Yasushi Shimonaka, Michinori Hirata
Epoetin beta pegol (continuous erythropoiesis receptor activator; C.E.R.A.), or methoxy-polyethylene glycol-modified epoetin beta, is a long-acting erythropoiesis stimulating agent (ESA) that effectively maintains hemoglobin levels. It promotes proliferation of erythroid progenitor cells in hematopoietic organs and leads to increased reticulocyte and hemoglobin levels. However, the detailed erythropoietic effects of various ESAs on their target organs have yet to be clarified, and new approaches are needed to analyze tissue iron localization with structural information...
August 17, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28819422/the-neutrophil-lymphocyte-ratio-predicts-recurrence-of-cervical-intraepithelial-neoplasia
#2
Sungwook Chun, Kyusik Shin, Ki Hyung Kim, Heung Yeol Kim, Wankyu Eo, Ji Young Lee, Jeong Namkung, Sang Hoon Kwon, Suk Bong Koh, Hong-Bae Kim
OBJECTIVE: The purpose of the present study was to determine the prognostic significance of the neutrophil-lymphocyte ratio (NLR) in recurrence of cervical intraepithelial neoplasia (CIN). METHODS: We evaluated the NLR as a prognostic marker in the entire cohort of 230 patients who had undergone surgical resection and were diagnosed with CIN. Subjects were categorized into two different groups based on the NLR (NLR-high and NLR-low) using cutoff values determined by receiver operating characteristic (ROC) analysis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28818693/hybrid-photoacoustic-and-electrophysiological-recording-of-neurovascular-communications-in-freely-moving-rats
#3
Lei Xi, Tian Jin, Junli Zhou, Paul Carney, Hubei Jiang
Uncovering the relationships between neural activities and capillary-level hemodynamics such as blood flow and concentration of hemoglobin in the brain plays an important role in the study of animal behaviors and brain disorders. Here, we developed a miniature probe integrating a photoacoustic sensor and micro-electrodes to simultaneously record the dynamics of blood flow and total hemoglobin inside a single capillary and the activities of surrounding neurons with high spatiotemporal resolution in freely-moving rats...
August 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28818402/association-of-hemolysis-with-high-dose-intravenous-immunoglobulin-therapy-in-pediatric-patients-an-open-label-prospective-trial
#4
Alkim Oden Akman, Fatma Karaca Kara, Tulin Koksal, Bahar Cuhaci Cakir, Cuneyt Karagol, Tulin Sayli
Immunoglobulin therapy can be used to treat a wide variety of diseases. However, intravenous immunoglobin products can cause several adverse reactions, including hemolysis. The objective of this study was to determine the extent of anemia and hemolysis after high dose intravenous immunoglobin (2g/kg) and its relationship to the ABO blood type system and hemolytic anemia blood parameters in pediatric patients. Incidence of 'Intravenous immunoglobulin related hemolysis' was %19 (6/31) after high dose intravenous immunoglobulin therapy...
August 1, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28818166/assessment-of-quality-of-sleep-and-its-relationship-with-psychiatric-morbidity-and-socio-demographic-factors-in-the-patients-of-chronic-renal-disease-undergoing-hemodialysis
#5
Usama Bin Zubair, Batool Butt
OBJECTIVE: To assess the subjective sleep quality and its relationship with the presence of psychiatric morbidity in the patients suffering from chronic kidney disease (CKD) and undergoing the procedure of hemodialysis (HD); and analyze the associated socio-demographic factors. STUDY DESIGN: Cross-sectional descriptive study. PLACE AND DURATION OF STUDY: Nephrology Department, Military Hospital, Rawalpindi, from July to December 2016. METHODOLOGY: Patients of CKD undergoing the HD were included in the final analysis...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28817822/predictors-of-postoperative-non-chylous-massive-discharge-after-pancreaticoduodenectomy-for-pancreatic-ductal-adenocarcinoma
#6
Kyoji Ito, Yoshikuni Kawaguchi, Yoshihiro Sakamoto, Junichi Arita, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Pancreaticoduodenectomy (PD) is performed for pancreatic ductal adenocarcinoma (PDA) located at the pancreas head/body. Non-chylous massive discharge after PD is frequently encountered and can cause a vicious cycle of complications associated with severe dehydration and protein loss. METHODS: From August 2008 to June 2015, 102 patients who underwent PD for PDA were retrospectively reviewed. High non-chylous discharge was defined as postoperative daily serous discharge exceeding 10 mL/kg...
August 18, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28811856/serum-betatrophin-levels-and-clinical-features-in-patients-with-poorly-controlled-type-2-diabetes
#7
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: Betatrophin is a hormone mainly secreted by the liver that influences lipid metabolisms. The main purposes of this study were to investigate the effect of canagliflozin (a sodium glucose transporter 2 inhibitor) on circulating betatrophin levels, and to investigate the correlation of various markers associated with glucose and lipid metabolisms with betatrophin in patients with poorly controlled type 2 diabetes. METHODS: Patients were randomly divided into a control group (n = 15) and a canagliflozin-treated group (n = 15)...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811804/prevalence-of-sexual-dysfunction-in-saudi-women-with-type-2-diabetes-is-it-affected-by-age-glycemic-control-or-obesity
#8
Turki A AlMogbel, Hussein S Amin, Saad M AlSaad, Turky H AlMigbal
OBJECTIVE: Sexual dysfunction (SD), as a diabetes mellitus (DM)-related complication, is common among patients having diabetes. This study aimed to ascertain the prevalence of SD in Saudi women with type 2 DM and to determine whether age, glycemic control, and obesity are associated with SD or not. METHODS: A total of 275 Saudi women with type 2 diabetes took part in this cross-sectional study and filled out the Female Sexual Function Index through a fill-coded questionnaire in primary care clinics in King Khalid University Hospital, Riyadh, in the period between January 2013 and May 2013...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28807985/inhaled-carbon-monoxide-from-toxin-to-therapy
#9
Dean R Hess
Carbon monoxide (CO) is usually recognized as a toxic gas that can be used to assess lung function in the pulmonary function laboratory. The toxicity of CO relates to its high affinity for hemoglobin and other heme molecules, producing carboxyhemoglobin (HbCO). Despite that blood HbCO levels are commonly measured in patients with CO poisoning, the clinical presentation often does not correlate with the HbCO level, and clinical improvement in the patient's condition does not correlate with HbCO clearance. In patients with CO poisoning, administration of 100% O2 is standard practice...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28807442/age-is-related-to-neurological-outcome-in-patients-with-out-of-hospital-cardiac-arrest-ohca-receiving-therapeutic-hypothermia-th
#10
Se Jong Oh, Jin Joo Kim, Jae Ho Jang, In Cheol Hwang, Jae Hyuk Woo, Yong Su Lim, Hyuk Jun Yang
INTRODUCTION: In this study, we retrospectively reviewed the patients' outcomes after cardiac arrest based on age in one center, to determine whether geriatric patients had worse outcomes. METHODS: This was a single-center, retrospective cohort study. The patients admitted to the intensive care unit on successful resuscitation after OHCA were retrospectively identified and evaluated. RESULTS: This was a retrospective cohort study of patients over 18years of-age with return of spontaneous circulation (ROSC) (>24h) after cardiac arrest who were admitted to the emergency intensive care unit (EICU) and received post-cardiac arrest care between March 2007 and December 2013...
July 29, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28805970/a-novel-free-fatty-acid-receptor-1-gpr40-ffar1-agonist-mr1704-enhances-glucose-dependent-insulin-secretion-and-improves-glucose-homeostasis-in-rats
#11
Naoto Tsuda, Atsuko Kawaji, Toshihiro Sato, Mitsuhiro Takagi, Chika Higashi, Yutaka Kato, Kumiko Ogawa, Hiroyasu Naba, Munetaka Ohkouchi, Masaki Nakamura, Yoshitaka Hosaka, Junichi Sakaki
Activation of G protein-coupled receptor 40/Free fatty acid receptor 1 (GPR40/FFAR1), which is highly expressed in pancreatic β cells, is considered an important pharmacologic target for the treatment of type 2 diabetes mellitus. The aim of this study was to determine the effect of MR1704, a novel GPR40/FFAR1 agonist, on glucose homeostasis in rats. MR1704 is a highly potent and selective, orally bioavailable agonist with similar in vitro potencies among humans, mice, and rats. Treatment of rat islets with MR1704 increased glucose-dependent insulin secretion...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28804712/virtual-and-actual-humanoid-robot-control-with-four-class-motor-imagery-based-optical-brain-computer-interface
#12
Alyssa M Batula, Youngmoo E Kim, Hasan Ayaz
Motor-imagery tasks are a popular input method for controlling brain-computer interfaces (BCIs), partially due to their similarities to naturally produced motor signals. The use of functional near-infrared spectroscopy (fNIRS) in BCIs is still emerging and has shown potential as a supplement or replacement for electroencephalography. However, studies often use only two or three motor-imagery tasks, limiting the number of available commands. In this work, we present the results of the first four-class motor-imagery-based online fNIRS-BCI for robot control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28800876/the-effects-of-red-blood-cell-transfusion-on-tissue-oxygenation-and-the-microcirculation-in-the-intensive-care-unit-a-systematic-review
#13
REVIEW
Nathan D Nielsen, Ignacio Martin-Loeches, Catherine Wentowski
The transfusion of red blood cells (RBCs) is a common intervention in intensive care unit (ICU) patients, yet the benefits are far from clear in patients with moderate anemia (eg, hemoglobin (Hb) levels of 7-10 g/dL). Determining which of these patients benefit, and how to even define benefit, from transfusion is challenging. As the intended physiological benefit underpinning RBC transfusion is to improve tissue oxygenation, several studies utilizing a wide range of assessment techniques have attempted to study the effects of transfusion on tissue oxygenation and microcirculatory function...
July 21, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28800727/a-phased-snp-based-classification-of-sickle-cell-anemia-hbb-haplotypes
#14
Elmutaz M Shaikho, John J Farrell, Abdulrahman Alsultan, Hatem Qutub, Amein K Al-Ali, Maria Stella Figueiredo, David H K Chui, Lindsay A Farrer, George J Murphy, Gustavo Mostoslavsky, Paola Sebastiani, Martin H Steinberg
BACKGROUND: Sickle cell anemia causes severe complications and premature death. Five common β-globin gene cluster haplotypes are each associated with characteristic fetal hemoglobin (HbF) levels. As HbF is the major modulator of disease severity, classifying patients according to haplotype is useful. The first method of haplotype classification used restriction fragment length polymorphisms (RFLPs) to detect single nucleotide polymorphisms (SNPs) in the β-globin gene cluster. This is labor intensive, and error prone...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28797896/predictors-of-mortality-in-adults-with-sickle-cell-disease-admitted-to-intensive-care-unit-in-bahrain
#15
Sana Abdulaaziz Al Khawaja, Zainab Mahdi Ateya, Ridha Abdulla Al Hammam
OBJECTIVE: Sickle cell disease (SCD) is one of the most common genetic blood disorders in Bahrain. However, there is a paucity of data regarding the clinical presentation of SCD patients who require ICU admission. This study aimed to describe the epidemiological data of SCD patients admitted to the ICU and to identify predictors of mortality in order to help intensivists identify patients at most risk. METHOD: This study used a retrospective, descriptive, and correlational design...
July 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28794803/translation-and-cultural-adaptation-into-brazilian-culture-of-type-1-diabetes-distress-scale
#16
M S V M Silveira, T G Bovi, P F Oliveira, E J Pavin, L Fisher
BACKGROUND: Diabetes related distress is common in type 1 diabetes patients (T1D). High levels of diabetes distress are related to poor metabolic control. An instrument to evaluate diabetes distress in T1D patients is "type 1 diabetes scale-T1DDS". The aim of this study was to translate and culturally adapt the T1DDS into Brazilian culture. METHODS: T1DDS scale was translated into Portuguese. Back translation was performed and evaluated by a specialists committee...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28792710/effects-of-passive-smoking-on-glycemic-parameters-and-lipid-profiles-in-a-chinese-female-population
#17
Lijuan Gu, Jing Li, Gui Pan, Xiaojun Zhou, Jianmin Zhang, Xiaoyang Lai, Jianping Liu
BACKGROUND: The adverse effects of exposure to second-hand cigarette smoke on glucose and lipid parameters in women and the underlying mechanisms are not well understood. In this prospective community-based study, we examined the effects of passive smoking on glycemic parameters and lipid profiles in a Chinese female population. METHODS: Of 3197 healthy women enrolled (30 - 75 years), 2082 self-reported passive exposure to smoke (≥ 15 minutes/day, 3 days/week, > 1 year) and 1115 had no smoke exposure (control group)...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792166/evaluation-of-effect-of-ascorbic-acid-on-ferritin-and-erythropoietin-resistance-in-patients-of-chronic-kidney-disease
#18
N Nand, A R Deshmukh, R Mittal
OBJECTIVE: This study was planned to evaluate the effect of short term intravenous ascorbic acid on reducing ferritin and erythropoietin resistance in patients of chronic kidney disease (CKD) on maintenance haemodialysis (MHD). METHODS: Forty adult patients [20 patients in group A with increased serum ferritin level (>500 ng/ml), transferrin saturation (TSAT) ≤20% and 20 patients in group B with normal serum ferritin level (<200 ng/ml), TSAT ≤20%] of end stage renal disease (ESRD) with erythropoietin hyporesponsiveness undergoing maintenance hemodialysis were included in the study...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28790534/laboratory-and-genetic-biomarkers-associated-with-cerebral-blood-flow-velocity-in-hemoglobin-sc-disease
#19
Rayra Pereira Santiago, Camilo Vieira, Corynne Stephanie Ahouefa Adanho, Sanzio Silva Santana, Caroline Conceição Guarda, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Thassila Nogueira Pitanga, Junia Raquel Dutra Ferreira, Milena Magalhães Aleluia, Rodrigo Mota Oliveira, Dalila Luciola Zanette, Isa Menezes Lyra, Marilda Souza Goncalves
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV in HbSC children. Sixty-eight HbSC children were included; CBFV was analyzed by transcranial Doppler, and the time-averaged maximum mean velocity (TAMMV) was estimated. Hematological, biochemical, immunological, and genetic analyses were performed. TAMMV was negatively correlated with red blood cell count (RBC) count, hemoglobin, hematocrit, and direct bilirubin (DB), yet positively correlated with monocytes and ferritin...
2017: Disease Markers
https://www.readbyqxmd.com/read/28789915/association-of-general-and-abdominal-obesity-with-hypertension-dyslipidemia-and-prediabetes-in-the-predaps-study
#20
F Javier Sangrós, Jesús Torrecilla, Carolina Giráldez-García, Lourdes Carrillo, José Mancera, Teresa Mur, Josep Franch, Javier Díez, Albert Goday, Rosario Serrano, F Javier García-Soidán, Gabriel Cuatrecasas, Dimas Igual, Ana Moreno, J Manuel Millaruelo, Francisco Carramiñana, Manuel Antonio Ruiz, Francisco Carlos Pérez, Yon Iriarte, Ángela Lorenzo, María González, Beatriz Álvarez, Lourdes Barutell, M Soledad Mayayo, Mercedes Del Castillo, Emma Navarro, Fernando Malo, Ainhoa Cambra, Riánsares López, M Ángel Gutiérrez, Luisa Gutiérrez, Carmen Boente, J Javier Mediavilla, Luis Prieto, Luis Mendo, M José Mansilla, Francisco Javier Ortega, Antonia Borras, L Gabriel Sánchez, J Carlos Obaya, Margarita Alonso, Francisco García, Ángela Trinidad Gutiérrez, Ana M Hernández, Dulce Suárez, J Carlos Álvarez, Isabel Sáenz, F Javier Martínez, Ana Casorrán, Jazmín Ripoll, Alejandro Salanova, M Teresa Marín, Félix Gutiérrez, Jaime Innerárity, M Del Mar Álvarez, Sara Artola, M Jesús Bedoya, Santiago Poveda, Fernando Álvarez, M Jesús Brito, Rosario Iglesias, Francisca Paniagua, Pedro Nogales, Ángel Gómez, José Félix Rubio, M Carmen Durán, Julio Sagredo, M Teresa Gijón, M Ángeles Rollán, Pedro P Pérez, Javier Gamarra, Francisco Carbonell, Luis García-Giralda, J Joaquín Antón, Manuel de la Flor, Rosario Martínez, José Luis Pardo, Antonio Ruiz, Raquel Plana, Ramón Macía, Mercè Villaró, Carmen Babace, José Luis Torres, Concepción Blanco, Ángeles Jurado, José Luis Martín, Jorge Navarro, Gloria Sanz, Rafael Colas, Blanca Cordero, Cristina de Castro, Mercedes Ibáñez, Alicia Monzón, Nuria Porta, María Del Carmen Gómez, Rafael Llanes, J José Rodríguez, Esteban Granero, Manuel Sánchez, Juan Martínez, Patxi Ezkurra, Luis Ávila, Carlos de la Sen, Antonio Rodríguez, Pilar Buil, Paula Gabriel, Pilar Roura, Eduard Tarragó, Xavier Mundet, Remei Bosch, J Carles González, M Isabel Bobé, Manel Mata, Irene Ruiz, Flora López, Marti Birules, Oriol Armengol, Rosa Mar de Miguel, Laura Romera, Belén Benito, Neus Piulats, Beatriz Bilbeny, J José Cabré, Xavier Cos, Ramón Pujol, Mateu Seguí, Carmen Losada, A María de Santiago, Pedro Muñoz, Enrique Regidor
INTRODUCTION AND OBJECTIVES: Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin). METHODS: Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase)...
August 5, 2017: Revista Española de Cardiología
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