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Chronic elevated hemoglobin levels

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https://www.readbyqxmd.com/read/29466280/persistent-injury-associated-anemia-and-aging-novel-insights
#1
Tyler J Loftus, Kolenkode B Kannan, Christy S Carter, Jessica M Plazas, Juan C Mira, Scott C Brakenridge, Christiaan Leeuwenburgh, Philip A Efron, Alicia M Mohr
BACKGROUND: Hypercatecholaminemia and bone marrow dysfunction have been implicated in the pathophysiology of persistent injury-associated anemia. The elderly may be more vulnerable to bone marrow dysfunction due to high basal and peak catecholamine levels and impaired hematopoietic progenitor growth. We hypothesized that aging would adversely affect persistent injury-associated anemia. METHODS: Male Sprague-Dawley rats aged 8 to 9 weeks and F344-BN rats aged 25 months were randomized to naive controls, lung contusion plus hemorrhagic shock (LCHS), and LCHS plus daily chronic restraint stress (LCHS/CS)...
March 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29465053/erythropoietic-response-to-anaemia-of-dialysis-na%C3%A3-ve-patients-with-chronic-kidney-disease-in-zaria-north-west-nigeria
#2
L G Dogara, A Hassan, S Awwalu, L Okpetu, A D Waziri, A A Babadoko, I B Bosan, H M Muktar
Introduction: Chronic kidney disease (CKD) is a global health problem with an increasing prevalence worldwide. Anemia is one of its consistent and severe hematological complications although its mechanism is not fully elucidated. The primary defect could manifest as serum erythropoietin (sEPO) deficiency or EPO resistance. We set out to determine the erythropoietic response to anemia of patients with CKD and its relationship with their iron status in a cross-sectional descriptive study of 91 patients in various stages of CKD...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29451472/hepcidin-and-proinflammatory-markers-in-children-with-chronic-kidney-disease-a-case-control-study
#3
Kamal Kumar Goyal, Abhijeet Saha, Puneet Kaur Sahi, Manpreet Kaur, Nand Kishore Dubey, Parul Goyal, Ashish Dutt Upadhayay
BACKGROUND: Hepcidin is the main regulator of hepcidin-ferroportin axis and is elevated in children with chronic kidney disease (CKD). Anemia of CKD and its relation to hepcidin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in iron- and erythropoietin (EPO)-naïve, non-dialyzed children with CKD is under-studied. MATERIALS AND METHODS: This case-control study aimed to study the levels of hepcidin and other proinflammatory markers (IL-6, TNF-α, hs-CRP) and their relation with anemia in iron- and erythropoietin-naïve, non-dialysis CKD (stage 3 - 5) patients...
February 16, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29432804/effects-of-long-term-nitrate-supplementation-on-carbohydrate-metabolism-lipid-profiles-oxidative-stress-and-inflammation-in-male-obese-type-2-diabetic-rats
#4
Sevda Gheibi, Sajad Jeddi, Mattias Carlström, Hanieh Gholami, Asghar Ghasemi
PURPOSE: Supplementation with inorganic nitrate to boost the nitrate-nitrite-nitric oxide (NO) pathway, may act as a potential therapeutic agent in diabetes. The aim of this study was to determine the effects of nitrate on carbohydrate metabolism, lipid profiles, oxidative stress, and inflammation in obese type 2 diabetic rats. METHODS: Male Wistar rats were divided into 4 groups: Control, control + nitrate, diabetes, and diabetes + nitrate. Diabetes was induced using a high-fat diet and low-dose of streptozotocin...
February 10, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29409586/circulating-neutrophil-counts-decrease-in-response-to-mitigated-air-quality-in-stable-copd-patients
#5
Zi Li Zhang, Jian Wang, Fen Liu, Ming Jing Ding, Fei Liu, Si Fan Chen, Wen Ju Lu
This three-year study, based on the Guangzhou Institute of Respiratory Disease (GRID), chronic obstructive pulmonary disease (COPD) Biobank, was conducted in 36 COPD patients to estimate whether changes in levels of leukocytes, erythrocytes, hemoglobin, and platelets were related to changes in air pollutant concentration. Daily NO2 levels exhibited significant differences between baseline years and the 2010 Asian Game period. We observed significant reductions in leukocyte and neutrophils counts levels, by 15...
January 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29404920/management-of-anemia-in-patients-with-inflammatory-bowel-disease-ibd
#6
REVIEW
Dhruvan Patel, Chinmay Trivedi, Nabeel Khan
PURPOSE OF REVIEW: Anemia is the most common complication as well as an extra intestinal manifestation of inflammatory bowel disease (IBD). It is associated with a significant impact on patient's quality of life (QoL); as well it represents a common cause of frequent hospitalization, delay of hospital inpatient discharge and overall increased healthcare burden. In spite of all these, anemia is still often underdiagnosed and undertreated. Our aim in this review is to provide a pathway for physicians to help them achieve early diagnosis as well as timely and appropriate treatment of anemia which in turn would hopefully reduce the prevalence and subsequent complications of this condition among IBD patients...
February 5, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29402840/elevations-of-thrombotic-biomarkers-in-hemoglobin-h-disease
#7
Siriyakorn Chansai, Supan Fucharoen, Goonnapa Fucharoen, Arunee Jetsrisuparb, Worawan Chumpia
BACKGROUND: Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common clinical symptoms in β-thalassemia, especially β-thalassemia intermedia, but little is known about in α-thalassemia. This study aims to examine phosphatidylserine (PS) levels, platelet activation, and coagulation markers in splenectomized (S) and nonsplenectomy (NS) patients with hemoglobin (Hb) H disease...
January 18, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29394913/elevated-systemic-levels-of-the-matrix-metalloproteinase-inhibitor-timp-1-correlate-with-clinical-markers-of-cachexia-in-patients-with-chronic-pancreatitis-and-pancreatic-cancer
#8
Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L Prokopchuk, Elaine C Schubert, Helmut Friess, Marc E Martignoni, Achim Krüger
BACKGROUND: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia and jaundice, two common PDAC-associated conditions. METHODS: Plasma TIMP-1 was measured by ELISA in patients diagnosed with PDAC (n = 36) and chronic pancreatitis (CP) (n = 25). Patients without pancreatic pathologies and known malignancies of other origin served as controls (n = 13)...
February 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29386306/brachial-ankle-pulse-wave-velocity-could-be-a-predictor-of-mortality-in-patients-on-peritoneal-dialysis
#9
Lailiang Wang, Qun Luo, Beixia Zhu, Fangfang Zhou
BACKGROUND AND OBJECTIVE: Elevated pulse wave velocity (PWV) has been associated with higher mortality in the general population, chronic kidney disease (CKD) patients, and hemodialysis patients. However, in peritoneal dialysis (PD) patients, this association has received little attention. The aim of this study was to evaluate the association between baseline brachial-ankle PWV (baPWV) levels and total mortality in PD patients. METHODS: In this single-center retrospective cohort study, 254 incident PD patients with baseline baPWV were followed up from 1 January 2013 to 31 July 2016...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29343652/painless-thyroiditis-and-fulminant-type-1-diabetes-mellitus-in-a-patient-treated-with-an-immune-checkpoint-inhibitor-nivolumab
#10
Kanako Sakurai, Satsuki Niitsuma, Ryota Sato, Kazuhiro Takahashi, Zenei Arihara
The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. Nivolumab, an anti-PD-1 monoclonal antibody, blocks PD-1 and can restore anti-cancer immune responses by disrupting the signal that inhibits T-cell activation. Nivolumab may induce endocrine-related adverse events, including hypophysitis, autoimmune thyroiditis, and type 1 diabetes mellitus. Here we report a 68-year-old female patient with advanced renal cell carcinoma who was treated with nivolumab...
January 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29320547/dyslipidemia-chronic-inflammation-and-subclinical-atherosclerosis-in-children-and-adolescents-infected-with-hiv-the-posithive-health-study
#11
Luiz Rodrigo Augustemak de Lima, Edio Luiz Petroski, Yara Maria Franco Moreno, Diego Augusto Santos Silva, Erasmo Benício de Moraes Santos Trindade, Aroldo Prohmann de Carvalho, Isabela de Carlos Back
HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc...
2018: PloS One
https://www.readbyqxmd.com/read/29295969/the-saudi-diabetic-kidney-disease-study-saudi-dkd-clinical-characteristics-and-biochemical-parameters
#12
Khalid Al-Rubeaan, Khalid Siddiqui, Mohammed Alghonaim, Amira M Youssef, Dhekra AlNaqeb
BACKGROUND: Saudi Arabia is facing an epidemic of type 2 diabetes that is complicated by a high rate of chronic complications such as kidney disease, which have a major impact on the healthcare system and economy. The Saudi diabetic kidney disease (SAUDI-DKD) study was launched to understand the implications of chronic diabetic kidney disease . OBJECTIVES: Examine the hematological, biochemical and metabolic parameters of the selected cohorts to look for biomarkers of diabetic nephropathy...
January 3, 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29287218/high-serum-adiponectin-is-associated-with-anemia-development-in-chronic-kidney-disease-the-results-from-the-know-ckd-study
#13
Hyoungnae Kim, Hae-Ryong Yun, Seohyun Park, Jong Hyun Jhee, Jung Tak Park, Tae-Hyun Yoo, Kyu-Beck Lee, Yeong-Hoon Kim, Su-Ah Sung, Joongyub Lee, Shin-Wook Kang, Kyu Hun Choi, Curie Ahn, Seung Hyeok Han
BACKGROUND: Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients...
March 2018: Cytokine
https://www.readbyqxmd.com/read/29237417/red-cell-distribution-width-associated-with-adverse-cardiovascular-outcomes-in-patients-with-chronic-kidney-disease
#14
Yueh-An Lu, Pei-Chun Fan, Cheng-Chia Lee, Victor Chien-Chia Wu, Ya-Chung Tian, Chih-Wei Yang, Yung-Chang Chen, Chih-Hsiang Chang
BACKGROUND: Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RDW levels. In this study, we investigated the effect of RDW on major composite CV outcomes among patients with CKD. METHODS: We retrospectively analyzed patients with CKD who were admitted to the department of cardiology of a tertiary hospital in 2011...
December 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29206072/cigarette-smoking-reduces-platelet-reactivity-independently-of-clopidogrel-treatment-in-patients-with-non-st-elevation-acute-coronary-syndromes
#15
Gabriele Crimi, Alberto Somaschini, Marco Cattaneo, Dominick J Angiolillo, Federico Piscione, Tullio Palmerini, Stefano De Servi
Smokers receiving clopidogrel show a lower residual platelet reactivity than non-smokers, a phenomenon generally ascribed to smoking-induced increased production of clopidogrel active metabolite, but also associated with the high hemoglobin levels of smokers, which decreases platelet reactivity in tests that measure platelet function in whole blood. We evaluated the impact of cigarette smoking and of hemoglobin levels on platelet reactivity index (PRI) measured by the vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) assay in whole blood samples from patients with non-ST elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary interventions, both before and after clopidogrel administration...
December 5, 2017: Platelets
https://www.readbyqxmd.com/read/29162584/individualized-glycemic-goals-and-an-expanded-classification-of-severe-hypoglycemia-in-diabetes
#16
Philip E Cryer
The view that a hemoglobin A1c (A1C) level <7% (55 mmol/mol) is the accepted glycemic goal for most people with diabetes sometimes conflicts with the view that glycemic goals should be individualized and, thus, that somewhat higher A1C levels are appropriate for some, particularly many at risk for iatrogenic hypoglycemia because of treatment with insulin, a sulfonylurea, or a glinide. The relationship between A1C and chronic complications of diabetes is curvilinear, A1C is a relatively weak predictor of cardiovascular disease, and minor elevations of A1C above 7% have not been found to be associated with increased mortality...
December 2017: Diabetes Care
https://www.readbyqxmd.com/read/29108337/elevated-hemoglobin-glycation-index-identify-non-diabetic-individuals-at-increased-risk-of-kidney-dysfunction
#17
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals. The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29058070/prognostic-value-of-plasma-nt-probnp-levels-in-very-old-patients-with-moderate-renal-insufficiency-in-china
#18
Peng Gao, Qiwei Zhu, Suyan Bian, Hongwei Liu, Hongping Xie
BACKGROUND: The N‑terminal pro-brain natriuretic peptide (NT-proBNP) has an important prognostic value in chronic renal insufficiency; however, most studies have been conducted in patients with end-stage renal disease (ESRD). In this study we evaluated the prognostic significance of NT-proBNP in very old patients with stage 3 chronic kidney disease (CKD) and compared its prognostic value in CKD3a versus CKD3b patients. METHODS: Patients (age ≥80 years old) hospitalized with stage 3 CKD from 2007 to 2010 who were eligible for this prospective study underwent follow-up examinations in 2015...
October 20, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29033310/relation-of-elevated-serum-uric-acid-levels-to-first-degree-heart-block-and-other-cardiac-conduction-defects-in-hospitalized-patients-with-type-2-diabetes
#19
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
AIMS: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. METHODS: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014...
December 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29029935/review-the-relationship-of-hemoglobin-a1c-to-postoperative-surgical-risk-with-an-emphasis-on-joint-replacement-surgery
#20
REVIEW
Lizette F Lopez, Peter D Reaven, Sherman M Harman
Patients with diabetes mellitus are known to have a high risk of postoperative complications, including infections, impaired wound healing, cardiovascular events, venous thromboembolism, and mortality. Because hyperglycemia has been thought to mediate this risk, there is a clinical propensity for improving glycemic control, as assessed by hemoglobin A1c (HbA1c) level, prior to proceeding with elective surgery, particularly joint replacement surgery. However, it is not established whether chronic poor glycemic control, indicated by elevated HbA1c levels, predicts increased risk of postoperative complications...
September 7, 2017: Journal of Diabetes and its Complications
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