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Chronic elevated hemoglobin levels

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https://www.readbyqxmd.com/read/28099381/daily-propranolol-administration-reduces-persistent-injury-associated-anemia-following-severe-trauma-and-chronic-stress
#1
Ines G Alamo, Kolenkode B Kannan, Letitia E Bible, Tyler J Loftus, Harry Ramos, Philip A Efron, Alicia M Mohr
BACKGROUND: Following severe trauma, patients develop a norepinephrine-mediated persistent, injury-associated anemia. This anemia is associated with suppression of bone marrow erythroid colony growth, along with decreased iron levels, and elevated erythropoietin (EPO) levels, which are insufficient to promote effective erythropoiesis. The impact of norepinephrine on iron regulators such as ferroportin, transferrin and transferrin receptor-1 (TFR-1) are unknown. Using a clinically relevant rodent model of lung contusion (LC), hemorrhagic shock (HS), and chronic stress (CS), we hypothesize that daily propranolol (BB), a non-selective beta-blocker, restores bone marrow function and improves iron homeostasis...
January 17, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28097367/impaired-glucose-homeostasis-in-first-episode-schizophrenia-a-systematic-review-and-meta-analysis
#2
Toby Pillinger, Katherine Beck, Cristian Gobjila, Jacek G Donocik, Sameer Jauhar, Oliver D Howes
Importance: Schizophrenia is associated with an increased risk of type 2 diabetes. However, it is not clear whether schizophrenia confers an inherent risk for glucose dysregulation in the absence of the effects of chronic illness and long-term treatment. Objective: To conduct a meta-analysis examining whether individuals with first-episode schizophrenia already exhibit alterations in glucose homeostasis compared with controls. Data Sources: The EMBASE, MEDLINE, and PsycINFO databases were systematically searched for studies examining measures of glucose homeostasis in antipsychotic-naive individuals with first-episode schizophrenia compared with individuals serving as controls...
January 11, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28050765/association-of-periodontal-disease-with-glycemic-control-in-patients-with-type-2-diabetes-in-indian-population
#3
Palka Kaur Khanuja, Satish Chander Narula, Rajesh Rajput, Rajinder Kumar Sharma, Shikha Tewari
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined...
January 3, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28045962/association-of-tsh-elevation-with-all-cause-mortality-in-elderly-patients-with-chronic-kidney-disease
#4
Mei-Hsing Chuang, Kuo-Meng Liao, Yao-Min Hung, Yi-Chang Chou, Pesus Chou
Chronic kidney disease (CKD) is a widespread condition in the global population and is more common in the elderly. Thyroid-stimulating hormone (TSH) level increases with aging, and hypothyroidism is highly prevalent in CKD patients. However, the relationship between low thyroid function and mortality in CKD patients is unclear. Therefore, we conducted a retrospective cohort study to examine the relationship between TSH elevation and all-cause mortality in elderly patients with CKD. This retrospective cohort study included individuals ≥65 years old with CKD (n = 23,786) in Taipei City...
2017: PloS One
https://www.readbyqxmd.com/read/28028749/oral-cyclophosphamide-was-effective-for-coombs-negative-autoimmune-hemolytic-anemia-in-cd16-cd56-chronic-lymphoproliferative-disorder-of-nk-cells
#5
Nodoka Sekiguchi, Sayaka Nishina, Toru Kawakami, Hitoshi Sakai, Noriko Senoo, Yasushi Senoo, Toshiro Ito, Hiroshi Saito, Hideyuki Nakazawa, Tomonobu Koizumi, Fumihiro Ishida
An 84-year-old woman was referred to our hospital presenting anemia. Her hemoglobin level was 5.8 g/dL, and white blood cell count was 9400/μL, consisting of 82% lymphocytes. Given the lymphocyte phenotype (CD2+, CD3-, CD16+, and CD56-) and negative whole blood EBV viral load, we made a diagnosis of chronic lymphoproliferative disorder of NK cells (CLPD-NK). We suspected hemolytic anemia because of the high levels of reticulocytes in the peripheral blood and the low haptoglobin value. Although the direct Coombs test was negative and there was no cold agglutination, we examined her red-blood-cell-bound IgG (RBC-IgG), which was elevated...
December 27, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27995726/glycemic-control-indicator-levels-at-diagnosis-of-neonatal-diabetes-mellitus-comparison-with-other-types-of-insulin-dependent-diabetes-mellitus
#6
Shigeru Suzuki, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azuma, Yukihiro Bando, Soji Kasayama, Masafumi Koga
BACKGROUND: Neonatal diabetes mellitus (NDM) is a monogenic insulin-dependent diabetes that develops within 6 months of age. The progression of hyperglycemia until diagnosis is unknown. Glycemic control indicators at diagnosis are useful to estimate the extent and duration of hyperglycemia. We recently established that age-adjusted glycated albumin (GA) is a useful indicator of glycemic control, regardless of age. OBJECTIVE: To compare the levels of various glycemic control indicators at diagnosis between NDM and other types of insulin-dependent diabetes mellitus...
December 20, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27980496/reversal-of-irritable-bowel-syndrome-sleep-disturbance-and-fatigue-with-an-elimination-diet-lifestyle-modification-and-dietary-supplements-a-case-report
#7
Stephanie Davis
BACKGROUND: A 53-y-old Caucasian patient presented in August 2015 with chief complaints of irritable bowel syndrome (IBS; gas/bloating, gastroesophageal reflux), fatigue, and sleep disturbances. He also noted a history of chronic sinusitis, seasonal allergies, multiple chemical sensitivities, and right knee pain (3 surgeries). His primary care physician, in 2014, diagnosed prediabetes based on an elevated hemoglobin A1c and high-sensitivity C-reactive protein, which was treated with diet and lifestyle modification...
October 2016: Integrative Medicine
https://www.readbyqxmd.com/read/27882223/hepatitis-b-patients-exhibiting-mild-alanine-aminotransferase-elevation-a-comparative-analysis-of-treatment-with-and-without-bicyclol-tablets
#8
Yin Zhang, Yanming Xie, Yiying Zhang, Yan Liu, Yan Zhuang
The aim of the present study was to analyze the medicinal effect of Bicyclol tablets on patients with chronic hepatitis B (CHB) and concomitant mild alanine aminotransferase (ALT) elevation (40-80 IU/l). A retrospective cohort study, which included patients from the hospital information system (HIS; established by the Chinese Academy of Medical Sciences) viral hepatitis database comprised of 18 third-grade class A hospitals in China, was performed. Patients were divided into an exposed group (administered with Bicyclol tablets) and a non-exposed group (no administration of Bicyclol tablets)...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27843309/prognostic-role-of-d-dimer-for-in-hospital-and-1-year-mortality-in-exacerbations-of-copd
#9
Guoping Hu, Yankui Wu, Yumin Zhou, Zelong Wu, Liping Wei, Yuqun Li, GongYong Peng, Weiqiang Liang, Pixin Ran
BACKGROUND AND OBJECTIVE: Serum D-dimer is elevated in respiratory disease. The objective of our study was to investigate the effect of D-dimer on in-hospital and 1-year mortality after acute exacerbations of chronic obstructive pulmonary disease (AECOPD). METHODS: Upon admission, we measured 343 AECOPD patients' serum D-dimer levels and arterial blood gas analysis, and recorded their clinical characteristics. The level of D-dimer that discriminated survivors and non-survivors was determined using a receiver operator curve (ROC)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27829333/immune-status-in-children-with-beta-thalassemia-in-correlation-with-iron-overload-single-center-egyptian-study
#10
Adel Abd Elhaleim Hagag, Mohamed A Elgamsy, Hassan M El-Asy, Rasha M Gamal, Walid N Elshahaby, Enaam S Abd Elbar
BACKGROUND: 'Beta thalassemia is inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy'. 'Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload', which in addition to immune abnormalities, are common predisposing factors to infection in patients with thalassemia. Aim of this work was to study immune status including T lymphocyte subsets and serum immunoglobulin levels 'in children with beta- thalassemia in correlation with iron overload'...
November 7, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27816956/prognostic-value-of-glycated-hemoglobin-among-patients-with-st-segment-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#11
Guangxiao Li, Xiaowen Hou, Ying Li, Peng Zhang, Qiongrui Zhao, Juan Li, Jingpu Shi
Many studies have shown the prognostic significance of glycated hemoglobin (HbA1c) for overall coronary artery disease (CAD). But less is known about the role that HbA1c played in the prognosis of patients diagnosed with ST-segment elevation myocardial infarction (STEMI). Results from previous studies were controversial. Therefore, a meta-analysis was conducted to investigate whether admission HbA1c level was a predictor of short- and long-term mortality rates among patients diagnosed with STEMI. Relevant literatures were retrieved from the electronic databases up to March 2016...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27810612/inflammatory-cardio-metabolic-and-diabetic-profiling-of-chronic-schizophrenia
#12
R Balõtšev, K Koido, V Vasar, S Janno, K Kriisa, R Mahlapuu, U Ljubajev, M Parksepp, P Veiksaar, V Volke, A Lang, L Haring, M Zilmer, E Vasar
BACKGROUND: There is a growing interest in low-grade inflammatory and metabolic alterations in patients with chronic schizophrenia (SCH). METHODS: Inflammatory (tumor-necrosis factor-α [TNF-α], interferon-γ [IFN-γ], interleukins [IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10], monocyte chemo-attractant protein-1 [MCP-1]) and growth factors (vascular endothelial growth factor [VEGF], epidermal growth factor [EGF]) were measured in blood serum samples of 105 SCH patients and 148 control subjects (CS)...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27809650/erythropoietin-and-soluble-erythropoietin-receptor-a-role-for-maternal-vascular-adaptation-to-high-altitude-pregnancy
#13
Gabriel Wolfson, Enrique Vargas, Vaughn A Browne, Lorna G Moore, Colleen Glyde Julian
CONTEXT: An imbalance of pro- and anti-angiogenic factors is thought to be central to the widespread vascular dysfunction characteristic to preeclampsia (PreE). Erythropoietin (Epo), a pleiotrophic cytokine known for its erythropoietic effects, has important angiogenic and vasoactive properties, however its contribution to impaired maternal vascular responses in PreE is unknown. OBJECTIVE(S): Since chronic hypoxia raises the incidence of PreE we asked whether the chronic hypoxia of high altitude (HA) increased maternal Epo and soluble Epo receptor (sEpoR) levels, and whether such effects differed between PreE cases and normotensive controls at HA...
November 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27500952/hair-cortisol-concentration-and-glycated-hemoglobin-in-african-american-adults
#14
H Matthew Lehrer, Susan K Dubois, Julie Maslowsky, Mark L Laudenslager, Mary A Steinhardt
BACKGROUND: African Americans have higher diabetes prevalence compared to Whites. They also have elevated cortisol levels - indicating possible HPA axis dysregulation - which may raise blood glucose as part of the biological response to physiological and psychosocial stress. Little is known about chronic cortisol levels in African Americans, and even less about the role of chronically elevated cortisol in type 2 diabetes development in this racial group. PURPOSE: We used analysis of cortisol in hair to examine associations of long-term (∼3months) cortisol levels with glycated hemoglobin (HbA1c) in a group of African American adults...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27321965/intravenous-versus-oral-iron-supplementation-for-the-treatment-of-anemia-in-ckd-an-updated-systematic-review-and-meta-analysis
#15
Daniel Shepshelovich, Benaya Rozen-Zvi, Tomer Avni, Uzi Gafter, Anat Gafter-Gvili
BACKGROUND: Iron supplementation is crucial for the treatment of anemia of chronic kidney disease (CKD). Although intravenous (IV) iron is preferred for patients with CKD receiving dialysis (CKD stage 5D), the method of iron replacement for patients with CKD stages 3 to 5 is controversial. STUDY DESIGN: Systematic review and meta-analysis. A search was performed until October 2015 of MEDLINE, Cochrane Library, conference proceedings in nephrology, and reference lists of included trials...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27207972/plasma-levels-of-proprotein-convertase-subtilisin-kexin-type-9-are-elevated-in-patients-with-peripheral-artery-disease-and-associated-with-metabolic-disorders-and-dysfunction-in-circulating-progenitor-cells
#16
Ting-Hsing Chao, I-Chih Chen, Yi-Heng Li, Po-Tseng Lee, Shih-Ya Tseng
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with the presence and severity of peripheral artery disease (PAD) and with parameters of endothelial homeostasis. METHODS AND RESULTS: A post hoc analysis of 2 randomized trials (115 patients, 44 with PAD and 71 without atherosclerotic disease) was conducted. Patients with PAD had significantly higher plasma PCSK9 levels than those without (471...
May 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27160621/-effect-of-metabolic-uncontrolled-diabetes-mellitus-dm-on-the-resistance-index-of-renal-ir-interlobar-arteries-assessed-with-pulsed-doppler
#17
Luis Cesar Muraira-Cárdenas, Martín Barrios-Pérez
BACKGROUND: Diabetes mellitus is a chronic degenerative disease characterized by elevated hyperglycemia, triggering a series of processes and culminating in chronic, uncontrolled, cellular and vascular damage in different organs. OBJECTIVE: To assess whether the elevated glycosylated hemoglobin, microalbuminuria, and the time evolution of more than 10 years of diabetes mellitus are associated with elevated resistance index of the interlobar renal arteries assessed with pulsed Doppler in patients with metabolic uncontrolled diabetes mellitus...
March 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27142829/effect-of-normovolemic-hematocrit-changes-on-blood-pressure-and-flow
#18
Philippe Bonnin, José Vilar, Bernard I Levy
AIMS: In patients with chronic kidney disease (CKD), severe anemia is associated with increased cardiovascular risk. Although elevating hemoglobin (Hb) and hematocrit (Hct) levels with erythropoiesis-stimulating agents (ESA) improves patients' quality of life, normalization of Hb does not reduce cardiovascular risk and the reason remains unclear. MAIN METHODS: We measured the effect of acute isovolumic changes in Hct from 37±5 to 50±2% (mean±SD) on arterial blood pressure (BP), cardiac output (CO), and carotid and renal blood flow (BF), (1) in control rats and (2) after acute blockade of the nitric oxide (NO) pathway by l-NAME...
July 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27081865/effect-of-erythropoietin-stimulating-agents-on-vascular-endothelial-growth-factor-levels-in-patients-with-end-stage-renal-disease
#19
Jennifer L Saluk, Vinod Bansal, Debra Hoppensteadt, Daneyal Syed, Schuharazad Abro, Jawed Fareed
BACKGROUND: End stage renal disease (ESRD) is a debilitating disease that not only impacts quality of life, but also increases the risk of cardiovascular disease, stroke, and overall mortality. By improving our understanding of the molecular patterns seen in progression of chronic renal disease (CRD), we may be able to slow down and possibly even prevent progression renal failure. The vascular endothelial growth factor (VEGF) has been implicated as a major contributor to CRD disease progression, thus our aim was to profile the VEGF levels in patients with ESRD and to determine the effects of the erythropoietin stimulating agents (ESAs)...
April 15, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27043687/preoperative-low-serum-bicarbonate-levels-predict-acute-kidney-injury-after-cardiac-surgery
#20
Su-Young Jung, Jung Tak Park, Young Eun Kwon, Hyung Woo Kim, Geun Woo Ryu, Sul A Lee, Seohyun Park, Jong Hyun Jhee, Hyung Jung Oh, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. Although lower than normal serum bicarbonate levels are known to be associated with consecutive renal function deterioration in patients with chronic kidney injury, it is not well-known whether preoperative low serum bicarbonate levels are associated with the development of AKI in patients who undergo cardiac surgery. Therefore, the clinical implication of preoperative serum bicarbonate levels on AKI occurrence after cardiac surgery was investigated...
March 2016: Medicine (Baltimore)
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