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Chronic elevated hemoglobin levels

Yin Zhang, Yanming Xie, Yiying Zhang, Yan Liu, Yan Zhuang
The aim of the present study was to analyze the medicinal effect of Bicyclol tablets on patients with chronic hepatitis B (CHB) and concomitant mild alanine aminotransferase (ALT) elevation (40-80 IU/l). A retrospective cohort study, which included patients from the hospital information system (HIS; established by the Chinese Academy of Medical Sciences) viral hepatitis database comprised of 18 third-grade class A hospitals in China, was performed. Patients were divided into an exposed group (administered with Bicyclol tablets) and a non-exposed group (no administration of Bicyclol tablets)...
November 2016: Biomedical Reports
Guoping Hu, Yankui Wu, Yumin Zhou, Zelong Wu, Liping Wei, Yuqun Li, GongYong Peng, Weiqiang Liang, Pixin Ran
BACKGROUND AND OBJECTIVE: Serum D-dimer is elevated in respiratory disease. The objective of our study was to investigate the effect of D-dimer on in-hospital and 1-year mortality after acute exacerbations of chronic obstructive pulmonary disease (AECOPD). METHODS: Upon admission, we measured 343 AECOPD patients' serum D-dimer levels and arterial blood gas analysis, and recorded their clinical characteristics. The level of D-dimer that discriminated survivors and non-survivors was determined using a receiver operator curve (ROC)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Adel Abd Elhaleim Hagag, Mohamed A Elgamsy, Hassan M El-Asy, Rasha M Gamal, Walid N Elshahaby, Enaam S Abd Elbar
BACKGROUND: 'Beta thalassemia is inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy'. 'Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload', which in addition to immune abnormalities, are common predisposing factors to infection in patients with thalassemia. Aim of this work was to study immune status including T lymphocyte subsets and serum immunoglobulin levels 'in children with beta- thalassemia in correlation with iron overload'...
November 7, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
Guangxiao Li, Xiaowen Hou, Ying Li, Peng Zhang, Qiongrui Zhao, Juan Li, Jingpu Shi
Many studies have shown the prognostic significance of glycated hemoglobin (HbA1c) for overall coronary artery disease (CAD). But less is known about the role that HbA1c played in the prognosis of patients diagnosed with ST-segment elevation myocardial infarction (STEMI). Results from previous studies were controversial. Therefore, a meta-analysis was conducted to investigate whether admission HbA1c level was a predictor of short- and long-term mortality rates among patients diagnosed with STEMI. Relevant literatures were retrieved from the electronic databases up to March 2016...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
R Balõtšev, K Koido, V Vasar, S Janno, K Kriisa, R Mahlapuu, U Ljubajev, M Parksepp, P Veiksaar, V Volke, A Lang, L Haring, M Zilmer, E Vasar
BACKGROUND: There is a growing interest in low-grade inflammatory and metabolic alterations in patients with chronic schizophrenia (SCH). METHODS: Inflammatory (tumor-necrosis factor-α [TNF-α], interferon-γ [IFN-γ], interleukins [IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10], monocyte chemo-attractant protein-1 [MCP-1]) and growth factors (vascular endothelial growth factor [VEGF], epidermal growth factor [EGF]) were measured in blood serum samples of 105 SCH patients and 148 control subjects (CS)...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
Gabriel Wolfson, Enrique Vargas, Vaughn A Browne, Lorna G Moore, Colleen Glyde Julian
CONTEXT: An imbalance of pro- and anti-angiogenic factors is thought to be central to the widespread vascular dysfunction characteristic to preeclampsia (PreE). Erythropoietin (Epo), a pleiotrophic cytokine known for its erythropoietic effects, has important angiogenic and vasoactive properties, however its contribution to impaired maternal vascular responses in PreE is unknown. OBJECTIVE(S): Since chronic hypoxia raises the incidence of PreE we asked whether the chronic hypoxia of high altitude (HA) increased maternal Epo and soluble Epo receptor (sEpoR) levels, and whether such effects differed between PreE cases and normotensive controls at HA...
November 3, 2016: Journal of Clinical Endocrinology and Metabolism
H Matthew Lehrer, Susan K Dubois, Julie Maslowsky, Mark L Laudenslager, Mary A Steinhardt
BACKGROUND: African Americans have higher diabetes prevalence compared to Whites. They also have elevated cortisol levels - indicating possible HPA axis dysregulation - which may raise blood glucose as part of the biological response to physiological and psychosocial stress. Little is known about chronic cortisol levels in African Americans, and even less about the role of chronically elevated cortisol in type 2 diabetes development in this racial group. PURPOSE: We used analysis of cortisol in hair to examine associations of long-term (∼3months) cortisol levels with glycated hemoglobin (HbA1c) in a group of African American adults...
October 2016: Psychoneuroendocrinology
Daniel Shepshelovich, Benaya Rozen-Zvi, Tomer Avni, Uzi Gafter, Anat Gafter-Gvili
BACKGROUND: Iron supplementation is crucial for the treatment of anemia of chronic kidney disease (CKD). Although intravenous (IV) iron is preferred for patients with CKD receiving dialysis (CKD stage 5D), the method of iron replacement for patients with CKD stages 3 to 5 is controversial. STUDY DESIGN: Systematic review and meta-analysis. A search was performed until October 2015 of MEDLINE, Cochrane Library, conference proceedings in nephrology, and reference lists of included trials...
June 16, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Ting-Hsing Chao, I-Chih Chen, Yi-Heng Li, Po-Tseng Lee, Shih-Ya Tseng
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with the presence and severity of peripheral artery disease (PAD) and with parameters of endothelial homeostasis. METHODS AND RESULTS: A post hoc analysis of 2 randomized trials (115 patients, 44 with PAD and 71 without atherosclerotic disease) was conducted. Patients with PAD had significantly higher plasma PCSK9 levels than those without (471...
May 20, 2016: Journal of the American Heart Association
Luis Cesar Muraira-Cárdenas, Martín Barrios-Pérez
BACKGROUND: Diabetes mellitus is a chronic degenerative disease characterized by elevated hyperglycemia, triggering a series of processes and culminating in chronic, uncontrolled, cellular and vascular damage in different organs. OBJECTIVE: To assess whether the elevated glycosylated hemoglobin, microalbuminuria, and the time evolution of more than 10 years of diabetes mellitus are associated with elevated resistance index of the interlobar renal arteries assessed with pulsed Doppler in patients with metabolic uncontrolled diabetes mellitus...
March 2016: Gaceta Médica de México
Philippe Bonnin, José Vilar, Bernard I Levy
AIMS: In patients with chronic kidney disease (CKD), severe anemia is associated with increased cardiovascular risk. Although elevating hemoglobin (Hb) and hematocrit (Hct) levels with erythropoiesis-stimulating agents (ESA) improves patients' quality of life, normalization of Hb does not reduce cardiovascular risk and the reason remains unclear. MAIN METHODS: We measured the effect of acute isovolumic changes in Hct from 37±5 to 50±2% (mean±SD) on arterial blood pressure (BP), cardiac output (CO), and carotid and renal blood flow (BF), (1) in control rats and (2) after acute blockade of the nitric oxide (NO) pathway by l-NAME...
July 15, 2016: Life Sciences
Jennifer L Saluk, Vinod Bansal, Debra Hoppensteadt, Daneyal Syed, Schuharazad Abro, Jawed Fareed
BACKGROUND: End stage renal disease (ESRD) is a debilitating disease that not only impacts quality of life, but also increases the risk of cardiovascular disease, stroke, and overall mortality. By improving our understanding of the molecular patterns seen in progression of chronic renal disease (CRD), we may be able to slow down and possibly even prevent progression renal failure. The vascular endothelial growth factor (VEGF) has been implicated as a major contributor to CRD disease progression, thus our aim was to profile the VEGF levels in patients with ESRD and to determine the effects of the erythropoietin stimulating agents (ESAs)...
April 15, 2016: International Angiology: a Journal of the International Union of Angiology
Su-Young Jung, Jung Tak Park, Young Eun Kwon, Hyung Woo Kim, Geun Woo Ryu, Sul A Lee, Seohyun Park, Jong Hyun Jhee, Hyung Jung Oh, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. Although lower than normal serum bicarbonate levels are known to be associated with consecutive renal function deterioration in patients with chronic kidney injury, it is not well-known whether preoperative low serum bicarbonate levels are associated with the development of AKI in patients who undergo cardiac surgery. Therefore, the clinical implication of preoperative serum bicarbonate levels on AKI occurrence after cardiac surgery was investigated...
March 2016: Medicine (Baltimore)
L Lind, H Lithell, B Wenglc, U Wrege, S Ljunghall
Disturbances of calcium homeostasis might be involved in the pathogenesis of the metabolic derangements associated with uraemia. Indices of glucose and lipoprotein metabolism as well as blood pressure were measured in nine patients with chronic renal failure who were on regular hemodialysis. Seven of them thereafter received alphacal-cidol (a synthetic analogue to active vitamin D) intravenously for three months. Prior to therapy the patients had, compared with age and sex matched controls, impaired glucose tolerance, hyperlipoproteinemia and raised blood pressure...
January 1988: Scandinavian Journal of Urology and Nephrology
Matthew M Hsieh, David Callacondo, Jose Rojas-Camayo, Jose Quesada-Olarte, Xunde Wang, Naoya Uchida, Irina Maric, Alan T Remaley, Fabiola Leon-Velarde, Francisco C Villafuerte, John F Tisdale
Chronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized that modest increases in fetal hemoglobin (HbF) are associated with lower CMS severity. In this cross-sectional study, we found that HbF levels were normal (median = 0.4%) in all 153 adult Andean natives in Cerro de Pasco, Peru. Compared with healthy adults, the borderline elevated hemoglobin group frequently had symptoms (headaches, tinnitus, cyanosis, dilatation of veins) of CMS...
June 2016: Experimental Hematology
Robert Krysiak, Małgorzata Gilowska, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Chronic metformin treatment was found to reduce elevated thyrotropin levels. Amiodarone treatment is associated with a range of effects in thyroid function from mild derangements to overt thyroid dysfunction. No previous study has investigated the effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with amiodarone-induced hypothyroidism. METHODS: The study included three age-, sex- and weight-matched groups of amiodarone-treated patients with type 2 diabetes: patients with treated overt hypothyroidism (group I, n=15), patients with untreated subclinical hypothyroidism (group II, n=15), and subjects without thyroid disorders (group III, n=18)...
April 2016: Pharmacological Reports: PR
Susan Felder, Nina Braun, Zeno Stanga, Prasad Kulkarni, Lukas Faessler, Alexander Kutz, Deborah Steiner, Svenja Laukemann, Sebastian Haubitz, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND AND AIMS: Malnutrition is associated with poor clinical outcomes. Whether there is a causal relationship or it merely mirrors a severe patient condition remains unclear. We examined the association of malnutrition with biomarkers characteristic of different pathophysiological states to better understand the underlying etiological mechanisms. METHODS: We prospectively followed consecutive adult medical inpatients. Multivariable regression models were used to investigate the associations between malnutrition - as assessed using the Nutritional Risk Screening (NRS 2002) - and biomarkers linked to inflammation, stress, renal dysfunction, nutritional status and hematologic function...
2016: Annals of Nutrition & Metabolism
Carlos Walter Sobrado, Rodolfo Delfini Cançado, Lucas Faraco Sobrado, Marcos Onofre Frugis, Marcel Faraco Sobrado
OBJECTIVES: Anemia is the most common hematological alteration in patients with Crohn's disease, and is frequently related to intestinal inflammatory activity. Its cause is multifactorial and mostly associated with absolute iron deficiency (iron deficiency anemia) and/or functional iron deficiency (inflammation anemia or anemia of chronic disease). It may also be identified through other causes, such as folic acid or vitamin B12 deficiency and secondary to adverse effects from medications (salicylic derivatives and immunosuppressive drugs)...
December 2015: Arquivos de Gastroenterologia
Pietro E Cippà, Scott O Grebe, Thomas Fehr, Rudolf P Wüthrich, Thomas F Mueller
The kidney is very susceptible to hypoxic injury. Calcineurin inhibitors (CNIs) induce vasoconstriction and might reduce renal tissue oxygenation. We aimed to investigate if the synergistic deleterious effects of CNI-treatment and hypoxia of high altitude living might accelerate the development of arteriolar hyalinosis in kidney allografts. We stratified all patients who received a kidney graft from 2000 to 2010 in our centre (n = 477) in three groups according to the residential elevation (below 400, between 400 to 600 and above 600 m above sea level) and we retrospectively re-evaluated all transplant biopsies performed during follow-up, specifically looking at the degree of arteriolar hyalinosis, the hallmark of chronic CNI nephrotoxicity...
September 2016: Nephrology
Agnieszka Butwicka, Wojciech Fendler, Adam Zalepa, Agnieszka Szadkowska, Malgorzata Zawodniak-Szalapska, Agnieszka Gmitrowicz, Wojciech Mlynarski
BACKGROUND: Type 1 diabetes mellitus (T1DM) is a chronic condition with major effect on health-related quality of life (HRQoL) and mental health. In 1990s, high rates of psychiatric disorders were reported among children with T1DM. Little is known, however, about current prevalence of psychiatric disorders in children with T1DM and the relation between psychiatric diagnosis and HRQoL. OBJECTIVE: The aim of the study was to determine the prevalence of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) psychiatric disorders and the association between psychiatric comorbidity and HRQoL in the pediatric population with T1DM...
March 2016: Psychosomatics
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