keyword
https://read.qxmd.com/read/38526827/investigation-of-microwave-extraction-of-red-cabbage-and-its-neurotherapeutic-potential
#21
JOURNAL ARTICLE
Halil Koyu, Serdar Demir, Mehmet Zeki Haznedaroglu
In the pursuit of bioactive compounds with health benefits from food and medicinal plants, optimization of process to reduce solvent, raw material, energy and time consumption has been a valuable research objective. Sustainable management and efficient use of natural resources are of critical importance for sustainability goals. In this manner, microwave extraction of red cabbage which has been a mass cultivated plant for food purposes, was optimized for maximizing acetylcholinesterase, butyrylcholinesterase, tyrosinase inhibitory activity and bioactive content...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526661/molecular-identification-and-phytochemical-analysis-and-bioactivity-assessment-of-catharanthus-roseus%C3%A2-leaf-extract-exploring-antioxidant-potential-and-antimicrobial-activities
#22
JOURNAL ARTICLE
Velusamy Arulvendhan, Periyakali Saravana Bhavan, Rajapandian Rajaganesh
Plants have long been at the main focus of the medical industry's attention due to their extensive list of biological and therapeutic properties and ethnobotanical applications. Catharanthus roseus, sometimes referred to as Nithyakalyani in Tamil, is an Apocynaceae family member used in traditional Indian medicine. It also examines the plant's potential antimicrobial and antioxidant activities as well as its preliminary phytochemical makeup. Leaf material from C. roseus was analyzed and found to include a variety of phytochemicals including alkaloids, terpenoids, flavonoids, tannins, phenols, saponins, glycosides, quinones, and steroids...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38525309/bioactive-coating-provides-antimicrobial-protection-through-immunomodulation-and-phage-therapeutics
#23
REVIEW
Kenny Zhuoran Wu, Zhicheng Le, Ba Myint, Brian Chan, Ling Liu, Hua Huang, Swee Leong Sing, Andy Tay
Medical implant-associated infections (IAI) is a growing threat to patients undergoing implantation surgery. IAI prevention typically relies on medical implants endowed with bactericidal properties achieved through surface modifications with antibiotics. However, the clinical efficacy of this traditional paradigm remains suboptimal, often necessitating revision surgery and posing potentially lethal consequences for patients. To bolster the existing anti-IAI arsenal, we propose herein a chitosan-based bioactive coating, i...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38524444/prioritizing-biomaterial-driven-clinical-bioactivity-over-designing-intricacy-during-bioprinting-of-trabecular-microarchitecture-a-clinician-s-perspective
#24
REVIEW
Sahith Kumar Shetty, Shyam Sundar Santhanakrishnan, Shubha Padurao, Pandareesh Mirazkar Dasharatharao
Bone tissue engineering has witnessed a historical shift from three perspectives. From a biomaterial perspective, materials have now become smarter and dynamic; from a bioengineering perspective the bioprinting techniques have now advanced to 4D bioprinting; and from a clinical perspective scaffold bioactivity has progressed toward enhanced osteoinductive scaffolds driven by intricate biomechanical, biophysical, biochemical, and biological cues. Though all of these advancements are indicative of improvised scaffold engineering, a pivotal question regarding the critical role and need of designing and replicating the intricacies of trabecular microarchitecture for enhanced, clinically appreciable osteoangiogenicity needs to be answered...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524031/gold-nanoparticles-in-parkinson-s-disease-therapy-a-focus-on-plant-based-green-synthesis
#25
REVIEW
Tsenka Grancharova, Stanislava Simeonova, Bissera Pilicheva, Plamen Zagorchev
Parkinson's disease (PD) is a progressive neurodegenerative disease that affects approximately 1% of people over the age of 60 and 5% of those over the age of 85. Current drugs for Parkinson's disease mainly affect the symptoms and cannot stop its progression. Nanotechnology provides a solution to address some challenges in therapy, such as overcoming the blood-brain barrier (BBB), adverse pharmacokinetics, and the limited bioavailability of therapeutics. The reformulation of drugs into nanoparticles (NPs) can improve their biodistribution, protect them from degradation, reduce the required dose, and ensure target accumulation...
February 2024: Curēus
https://read.qxmd.com/read/38523705/aiming-at-early-stage-vulnerable-plaques-a-nanoplatform-with-dual-mode-imaging-and-lipid-inflammation-integrated-regulation-for-atherosclerotic-theranostics
#26
JOURNAL ARTICLE
Yao Wang, Zhebin Chen, Qiongjun Zhu, Zhezhe Chen, Guosheng Fu, Boxuan Ma, Wenbin Zhang
The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events. Thus, timely diagnosis and treatment of vulnerable plaques in early stage can effectively benefit the clinical management of atherosclerosis. In this work, a targeting theranostic strategy on early-stage vulnerable plaques in atherosclerosis is realized by a LAID nanoplatform with X-CT and fluorescent dual-mode imaging and lipid-inflammation integrated regulation abilities. The iodinated contrast agents (ICA), phenylboronic acid modified astaxanthin and oxidized-dextran (oxDEX) jointly construct the nanoparticles loaded with the lipid-specific probe LFP...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38523704/engineering-lnps-with-polysarcosine-lipids-for-mrna-delivery
#27
JOURNAL ARTICLE
Diana D Kang, Xucheng Hou, Leiming Wang, Yonger Xue, Haoyuan Li, Yichen Zhong, Siyu Wang, Binbin Deng, David W McComb, Yizhou Dong
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stimulate the generation of anti-PEG antibodies. The presence of these antibodies can potentially cause adverse reactions and reduce therapeutic efficacy after administration. Given the widespread deployment of the COVID-19 vaccines, the increased exposure to PEG may necessitate the evaluation of alternative LNP formulations without PEG components...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38523703/effects-of-mgo-nanoparticle-addition-on-the-mechanical-properties-degradation-properties-antibacterial-properties-and-in-vitro-and-in-vivo-biological-properties-of-3d-printed-zn-scaffolds
#28
JOURNAL ARTICLE
Leiting Yu, Fengdong Sun, Yuanyuan Wang, Wei Li, Yufeng Zheng, Guangxin Shen, Yao Wang, Minfang Chen
Bone tissue engineering is the main method for repairing large segment bone defects. In this study, a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders, which allowed the MgO nanoparticles to be incorporated into 3D-printed Zn matrix and improved the biodegradation and biocompatibility of the Zn matrix. The results showed that porous pure Zn scaffolds and Zn/MgO scaffolds with skeletal-gyroid (G) model structure were successfully prepared by selective laser melting (SLM)...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38523515/composite-or-modified-hydroxyapatite-microspheres-as-drug-delivery-carrier-for-bone-and-tooth-tissue-engineering
#29
JOURNAL ARTICLE
Zhe Wang, Jiaxin Shang, Zheng Zhang
Since hydroxyapatite (HAp) is an important constituent of bone and teeth, it has excellent biocompatibility and bioactivity, good osteoconductive effects and the ability to induce bone formation as a material for bone or tooth repair and replacement. At present, widely used HAp microspheres have some characteristics, such as large specific surface area, light mass, good injection properties, good fluidity, and low aggregation ability, but they are difficult to really meet the biological and clinical needs due to their own mechanical property defects, such as low strength, brittleness, and poor plasticity...
March 22, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38522283/interfacial-blending-in-co-axially-electrospun-polymer-core-shell-fibers-and-their-interaction-with-cells-via-focal-adhesion-point-analysis
#30
JOURNAL ARTICLE
Martyna Polak, Daniel P Ura, Krzysztof Berniak, Piotr K Szewczyk, Mateusz M Marzec, Urszula Stachewicz
Electrospun polymer scaffolds have gained prominence in biomedical applications, including tissue engineering, drug delivery, and wound dressings, due to their customizable properties. As the interplay between cells and materials assumes fundamental significance in biomaterials research, understanding the relationship between fiber properties and cell behaviour is imperative. Nevertheless, altering fiber properties introduces complexity by intertwining mechanical and surface chemistry effects, challenging the differentiation of their individual impacts on cell behaviour...
March 20, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38521331/body-temperature-responsive-capsules-templated-from-pickering-emulsion-for-thermally-triggered-release-of-%C3%AE-carotene
#31
JOURNAL ARTICLE
Chunmiao Xia, Zihui Xu, Maodong Xu, Cuige Zhang, Bo Xu, Benhai Liu, Xin Yan, Zhenan Zheng, Rongli Zhang
In recent years, functional foods with lipophilic nutraceutical ingredients are gaining more and more attention because of its potential healthy and commercial value, and developing of various bioderived food-grade particles for use in fabrication of Pickering emulsion has attracted great attentions. Herein, the bio-originated sodium caseinate-lysozyme (Cas-Lyz) complex particles were firstly designed to be used as a novel interfacial emulsifier for Pickering emulsions. Pickering emulsions of various food oils were all successfully stabilized by the Cas-Lyz particles without addition of any synthetic surfactants, while the fluorescence microscopy and SEM characterizations clearly evidenced Cas-Lyz particles were attached on the surface of emulsion droplets...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521037/exploring-the-neurotoxicity-of-chiral-dinotefuran-towards-nicotinic-acetylcholine-receptors-enantioselective-insights-into-species-selectivity
#32
JOURNAL ARTICLE
Zhi-Cong He, Tao Zhang, Wei Peng, Qiong Mei, Qi-Zhao Wang, Fei Ding
Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but its health risks to different organisms are poorly understood. This study investigated the neurotoxic responses of honeybee/cotton aphid nicotinic acetylcholine receptors (nAChRs) to chiral dinotefuran at the enantiomeric scale and demonstrated the microscopic mechanism of species selectivity in nAChR-mediated enantioselective neurotoxicity. The findings indicated that (S)-dinotefuran had a higher affinity for honeybee nAChR than (R)-dinotefuran whereas both enantiomers exhibited similar bioactivity toward cotton aphid nAChR...
March 13, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38520286/preparation-and-characterization-of-zein-caseinate-pectin-complex-nanoparticles-for-encapsulation-of-curcumin-pectin-extracted-by-high-speed-shearing-from-passion-fruit-peel-passiflora-edulis-f-flavicarpa
#33
JOURNAL ARTICLE
Xiefei Li, Yupeng Lin, Yumeng Huang, Xin Li, An Fengping, Hongbo Song, Qun Huang
BACKGROUND: Pectin extracted by high-speed shearing from passion fruit peel (HSSP) is a potentially excellent wall material for encapsulating curcumin, which has multiple advantages over pectin prepared by heating water extraction. HSSP was used to fabricate the complex nanoparticles of zein (Z)-sodium caseinate (N)-pectin for encapsulation of curcumin in this study. The influence of heating on the physicochemical properties of the composite nanoparticles was also investigated, as well as the effect of composite nanoparticles on the encapsulation efficiency, antioxidant activity, and release characteristics of curcumin...
March 23, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38520188/the-m2-macrophages-derived-migrasomes-from-the-surface-of-titania-nanotubes-array-as-a-new-concept-for-enhancing-osteogenesis
#34
JOURNAL ARTICLE
Guangwen Li, Yuqi Zhao, Haochen Wang, Yan Zhang, Dongxuan Cai, Yumei Zhang, Wen Song
As a newly discovered substrate anchored extracellular vesicles, migrasomes (Migs) may bring a new opportunity for manipulating target cells bioactivities. In this study, the M2 macrophages derived Migs were obtained by titania nanotubes surface (NTs). Due to the benefits of nanostructured, the NTs surface was not only able to induce RAW264.7 for M2 polarization, but also generated more Migs formation, which could be internalized by following seeded mesenchymal stem cells (MSCs). Then the NTs surface induced Migs were collected by density-gradient centrifugation for MSCs treatment...
March 23, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38519046/hybrid-hydrogels-for-immunoregulation-and-pro-angiogenesis-through-mild-heat-stimulation-to-accelerate-whole-process-diabetic-wound-healing
#35
JOURNAL ARTICLE
Qianru Guo, Tianyu Yin, Wei Huang, Rui Nan, Tao Xiang, Shaobing Zhou
Intense and persistent oxidative stress, excessive inflammation and impaired angiogenesis severely hinder diabetic wound healing. Bioactive hydrogel dressings with immunoregulatory and pro-angiogenic properties have great promise in treating diabetic wounds. However, the therapeutic effects of dressings always depend on drugs with side effects, expensive cytokines and cell therapies. Herein, a novel dynamic borate-bonds crosslinked hybrid multifunctional hydrogel dressings with photothermal properties are developed to regulate the microenvironment of diabetic wound sites and accelerate the whole process of its healing without additional medication...
March 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38518823/safe-and-sustainable-by-design-ag-nanomaterials-a-case-study-to-evaluate-the-bio-reactivity-in-the-environment-using-a-soil-model-invertebrate
#36
JOURNAL ARTICLE
Susana I L Gomes, Ilaria Zanoni, Anna L Costa, Magda Blosi, Danail Hristozov, Janeck J Scott-Fordsmand, Mónica J B Amorim
Safe-and-sustainable-by-design (SSbD) nanomaterials (NMs) or NM-containing products are a priority. Silver (Ag) NMs have a vast array of applications, including biomedical and other products, even as nanopesticides. Thus, their release to the environment is expected to increase. The aim of the present study was to assess the ecotoxicity of the SSbD Ag NM to the soil model species Enchytraeus crypticus (Oligochaeta). The Ag NM tested consists in a SSbD Ag with biomedical applications, a hydroxyethyl cellulose (HEC) coated Ag NMs (AgHEC) and its toxicity was compared to the naked Ag NMs (Ag-Sigma), an Ag-based biomedical product (PLLA-Ag: Poly l-Lactide microfibers doped with Ag), and AgNO3 ...
March 20, 2024: Science of the Total Environment
https://read.qxmd.com/read/38518496/development-of-functional-consortia-for-the-pretreatment-of-compostable-lignocellulosic-waste-a-simple-and-effective-solution-to-a-large-scale-problem
#37
JOURNAL ARTICLE
J A López-González, F Suárez-Estrella, M M Jurado, M R Martínez-Gallardo, A Toribio, M J Estrella-González, M J López
Microorganisms drive the degradation of organic matter thanks to their enzymatic versatility. However, the structure of lignocellulose poses a great challenge for the microbiota inhabiting a compost pile. Our purpose was to increase the biodegradability of vegetable waste in the early stages of the composting process by applying a microbial consortium with lignocelllulolytic capacity. For this, a previous screening was performed among the culturable microbiota from different composting processes to find inoculants with ligninocellulolytic activity...
March 21, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38518368/preparation-of-celecoxib-loaded-bioactive-glass-chitosan-composite-hydrogels-a-simple-approach-for-therapeutic-delivery-of-nsaids
#38
JOURNAL ARTICLE
Azra Jalal, Sana Ahmad, Asma Tufail Shah, Tousif Hussain, Awais Nawaz, Saleha Imran
Arthritis causes inflammatory damage to joints and connective tissues. In the treatment of arthritis, precise and controlled drug delivery to the target site is among the frontline research approaches. In the present research work, celecoxib drug and bioactive glass incorporated chitosan hydrogels were fabricated by the freeze gelation method. FTIR, SEM, and TGA/DSC techniques were used to characterize the hydrogels. Different kinetic models were applied to study the drug release kinetics. The celecoxib release was mainly controlled by a Fickian diffusion process followed by the Higuchi model...
March 22, 2024: Biomedical Materials
https://read.qxmd.com/read/38518364/bone-morphogenetic-protein-2-loaded-triple-helix-recombinant-collagen-based-hydrogels-for-enhancing-bone-defect-healing
#39
JOURNAL ARTICLE
Huixia He, Fan Yang, Shanshan Zhang, Zhao Liu, Zaiman Liu, Linghui Yu, Jianxi Xiao
The development of efficacious bone substitute biomaterials remains a major challenge for research and clinical surgical. Herein, we constructed triple helix recombinant collagen -based hydrogels loading bone morphogenetic protein-2 (BMP-2) to stimulate bone regeneration in cranial defects. A series of in situ forming hydrogels, denoted as THRC-OCMC-NSC hydrogels, was synthesized via a Schiff base reaction involving oxidized carboxymethylcellulose (OCMC), triple helix recombinant collagen (THRC) and N-succinyl-chitosan (NSC)...
March 22, 2024: Biomedical Materials
https://read.qxmd.com/read/38518362/adipose-tissue-reconstruction-facilitated-with-low-immunogenicity-decellularized-adipose-tissue-scaffolds
#40
JOURNAL ARTICLE
Xun Yang, Lijuan Jin, Miaomiao Xu, Xiao Liu, Zhikai Tan, Lijun Liu
There is currently an urgent need to develop engineered scaffolds to support new adipose tissue formation and facilitate long-term maintenance of function and defect repair to further generate prospective bioactive filler materials capable of fulfilling surgical needs. Herein, adipose regeneration methods were optimized and decellularized adipose tissue (DAT) scaffolds with good biocompatibility were fabricated. Adipose-like tissues were reconstructed using the DAT and 3T3-L1 preadipocytes, which have certain differentiation potential, and the regenerative effects of the engineered adipose tissues in vitro and in vivo were explored...
March 22, 2024: Biomedical Materials
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