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https://www.readbyqxmd.com/read/29692857/gepsi-a-gene-expression-profile-similarity-based-identification-method-of-bioactive-components-in-traditional-chinese-medicine-formula
#1
Baixia Zhang, Shuaibing He, Chenyang Lv, Yanling Zhang, Yun Wang
The identification of bioactive components in traditional Chinese medicine (TCM) is an important part of the TCM material foundation research. Recently, molecular docking technology has been extensively used for the identification of TCM bioactive components. However, target proteins that are used in molecular docking may not be the actual TCM target. For this reason, the bioactive components would likely be omitted or incorrect. To address this problem, this study proposed the GEPSI method that identified the target proteins of TCM based on the similarity of gene expression profiles...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29691829/in-situ-cross-linkable-polymer-systems-and-composites-for-osteochondral-regeneration
#2
María Puertas-Bartolomé, Lorena Benito-Garzón, Marta Olmeda-Lozano
Injectable hydrogels have demonstrated being a promising strategy for cartilage and bone tissue engineering applications, owing to their minimal invasive injection procedure, easy incorporation of cells and bioactive molecules, improved contact with the surrounding tissues and ability to match defects with complex irregular shapes, characteristics of osteoarthritic pathology. These unique properties make them highly suitable bioscaffolds for treating defects which are otherwise not easily accessible without and invasive surgical procedure...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691828/silk-fibroin-based-hydrogels-and-scaffolds-for-osteochondral-repair-and-regeneration
#3
Viviana P Ribeiro, Sandra Pina, J Miguel Oliveira, Rui L Reis
Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691819/nanofibers-and-microfibers-for-osteochondral-tissue-engineering
#4
Zaida Ortega, María Elena Alemán, Ricardo Donate
The use of fibers into scaffolds is a way to mimic natural tissues, in which fibrils are embedded in a matrix. The use of fibers can improve the mechanical properties of the scaffolds and may act as structural support for cell growth. Also, as the morphology of fibrous scaffolds is similar to the natural extracellular matrix, cells cultured on these scaffolds tend to maintain their phenotypic shape. Different materials and techniques can be used to produce micrfibers- and nanofibers for scaffolds manufacturing; cells, in general, adhere and proliferate very well on PCL, chitosan, silk fibroin, and other nanofibers...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691817/bioceramics-for-osteochondral-tissue-engineering-and-regeneration
#5
Sandra Pina, Rita Rebelo, Vitor Manuel Correlo, J Miguel Oliveira, Rui L Reis
Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. Bioceramics have been developed to repair, reconstruct, and substitute diseased parts of the body and to promote tissue healing as an alternative to metallic implants. Applications embrace hip, knee, and ligament repair and replacement, maxillofacial reconstruction and augmentation, spinal fusion, bone filler, and repair of periodontal diseases. Bioceramics are well-known for their superior wear resistance, high stiffness, resistance to oxidation, and low coefficient of friction...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691036/nanofibers-of-cellulose-bagasse-from-agave-tequilana-weber-var-azul-by-electrospinning-preparation-and-characterization
#6
Miguel Ángel Robles-García, Carmen Lizette Del-Toro-Sánchez, Enrique Márquez-Ríos, Arturo Barrera-Rodríguez, Jacobo Aguilar, José A Aguilar, Francisco Javier Reynoso-Marín, I Ceja, R Dórame-Miranda, Francisco Rodríguez-Félix
In this study, cellulose of bagasse from Agave tequilana Weber var. azul was extracted to elaborate nanofibers by the electrospinning technique. Fiber characterization was performed using Transmission Electron Microscopy (TEM), x-ray, Fournier Transform-InfraRed (FT-IR) spectroscopy, and thermal analysis by Differential Scanning Calorimetry-Thermogravimetric Analysis (DSC-TGA). Different diameters (ranging from 54.57 ± 0.02 to 171 ± 0.01 nm) of nanofibers were obtained. Cellulose nanofibers were analyzed by means of x-ray diffraction, where we observed a total loss of crystallinity in comparison with the cellulose, while FT-IR spectroscopy revealed that the hemicellulose and lignin present in the agave bagasse were removed...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29688820/elucidating-differential-nano-bio-interactions-of-multi-walled-andsingle-walled-carbon-nanotubes-using-subcellular-proteomics
#7
Joseph D T Ndika, Jukka Sund, Harri Alenius, Anne Puustinen
Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable tool to uncover the molecular dynamics of hazardous exposures, yet challenges persist with regards to its limited dynamic range when sampling whole organisms, tissues or cell lysates. Here, the simplicity of the sub-cellular proteome was harnessed to unravel distinctive adverse exposure outcomes at the molecular level, between two CNT subtypes...
April 24, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29685150/antioxidant-and-cytotoxic-activities-of-dendrobium-moniliforme-extracts-and-the-detection-of-related-compounds-by-gc-ms
#8
Mukti Ram Paudel, Mukesh Babu Chand, Basant Pant, Bijaya Pant
BACKGROUND: The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D. moniliforme extracts and detected their bioactive compounds. METHODS: Plant material was collected from the Daman of Makawanpur district in central Nepal. Plant extracts were prepared from stems using hexane, chloroform, acetone, ethanol and methanol...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29682752/mineral-density-in-carious-dentine-after-treatment-with-calcium-silicates-and-polyacrylic-acid-based-cements
#9
P M Pires, T P Santos, A Fonseca-Gonçalves, M M Pithon, R T Lopes, A A Neves
AIM: To test the hypothesis that polyacrylic acid-based and calcium silicate materials are able to increase mineral density of artificially demineralized dentine produced by a microcosm model for caries formation. METHODOLOGY: Forty-five dentine cavities were prepared in 9 sound human third molars (5 in each tooth). Specimens received a bacterial inoculum and were incubated in BHI plus 5% of sucrose for 96h to allow biofilm formation. After that, the specimens were scanned in a high energy micro-CT (baseline stack) and then, each cavity was filled with different cements: zinc polycarboxylate (Poly Zinc™ , Prevest DenPro, Jammu, India), conventional glass ionomer (Ketac Molar, 3M ESPE, Seefeld, Germany) and two calcium silicate based materials (MTA, Angelus, Londrina, Brazil and Biodentine™ , Septodont, Saint Maur des Fosses, France) while the central cavity was filled with utility wax (negative control)...
April 22, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29682605/dual-affinity-heparin-based-hydrogels-achieve-pro-regenerative-immunomodulation-and-microvascular-remodeling
#10
Molly E Ogle, Jack R Krieger, Liane E Tellier, Jennifer McFaline-Figueroa, Johnna S Temenoff, Edward A Botchwey
The immune response to biomaterial implants critically regulates functional outcomes such as vascularization, transplant integration/survival, and fibrosis. To create "immunologically smart" materials, the host-material response may be engineered to optimize the recruitment of pro-regenerative leukocyte subsets which mature into corresponding wound-healing macrophages. We have recently identified a unique feature of pro-regenerative Ly6Clow monocytes that is a higher expression of both the bioactive lipid receptor sphingosine-1-phosphate receptor 3 (S1PR3) and the stromal derived factor-1α (SDF-1α) receptor CXCR4...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29682530/efficacy-of-rhbmp-2-loaded-pcl-%C3%AE-tcp-bdecm-scaffold-fabricated-by-3d-printing-technology-on-bone-regeneration
#11
Eun-Bin Bae, Keun-Ho Park, Jin-Hyung Shim, Ho-Yun Chung, Jae-Won Choi, Jin-Ju Lee, Chang-Hwan Kim, Ho-Jun Jeon, Seong-Soo Kang, Jung-Bo Huh
This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/ β -tricalcium phosphate ( β -TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/ β -TCP, PCL/ β -TCP/bdECM, and PCL/ β -TCP/bdECM/BMP groups. In vitro release kinetics of rhBMP-2 were determined with respect to cell proliferation and osteogenic differentiation. These three reconstructive materials were implanted into 8 mm diameter calvarial bone defect in male Sprague-Dawley rats...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29680723/mineral-trioxide-aggregate-with-mussel-inspired-surface-nanolayers-for-stimulating-odontogenic-differentiation-of-dental-pulp-cells
#12
Ming-Gene Tu, Chia-Che Ho, Tuan-Ti Hsu, Tsui-Hsien Huang, Min-Jhen Lin, Ming-You Shie
INTRODUCTION: This research was intended to evaluate the feasibility of mineral trioxide aggregate (MTA) powder coated with polydopamine (PDA) in dental and bone tissue regeneration by investigating the hydration, physicochemical properties, and biological performance of hydrated cements. METHODS: The MTA powder was well suspended in a dopamine solution buffered at a pH of 8.5 using tris(hydroxymethyl)aminomethane buffer and vigorously stirred for 12 hours at room temperature...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29678959/extracellular-vesicles-and-their-content-in-bioactive-lipid-mediators-more-than-a-sack-of-microrna
#13
Eric Boilard
Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane-bound vesicles released by cells under various conditions. In a multitude of physiological and pathological conditions, EVs contribute to intercellular communication by facilitating exchange of material between cells. Rapidly growing interest is aimed at better understanding EV function and their use as biomarkers. The vast EV cargo includes cytokines, growth factors, organelles, nucleic acids (messenger and micro RNA), and transcription factors...
April 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29676123/-data-fusion-and-multi-components-quantitative-analysis-for-identification-and-quality-evaluation-of-gentiana-rigescens-from-different-geographical-origins
#14
Qin-Qin Wang, Tao Shen, Zhi-Tian Zuo, Heng-Yu Huang, Yuan-Zhong Wang
The accumulation of secondary metabolites of traditional Chinese medicine (TCM) is closely related to its origins. The identification of origins and multi-components quantitative evaluation are of great significance to ensure the quality of medicinal materials. In this study, the identification of Gentiana rigescens from different geographical origins was conducted by data fusion of Fourier transform infrared (FTIR) spectroscopy and high performance liquid chromatography (HPLC) in combination of partial least squares discriminant analysis; meanwhile quantitative analysis of index components was conducted to provide an accurate and comprehensive identification and quality evaluation strategy for selecting the best production areas of G...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675216/total-chemical-synthesis-of-glycocin-f-and-analogues-s-glycosylation-confers-improved-antimicrobial-activity
#15
Zaid Amso, Sean W Bisset, Sung-Hyun Yang, Paul W R Harris, Tom H Wright, Claudio D Navo, Mark L Patchett, Gillian E Norris, Margaret A Brimble
Glycocin F (GccF) is a unique diglycosylated bacteriocin peptide that possesses potent and reversible bacteriostatic activity against a range of Gram-positive bacteria. GccF is a rare example of a 'glycoactive' bacteriocin, with both the O -linked N -acetylglucosamine (GlcNAc) and the unusual S -linked GlcNAc moiety important for antibacterial activity. In this report, glycocin F was successfully prepared using a native chemical ligation strategy and folded into its native structure. The chemically synthesised glycocin appeared to be slightly more active than the recombinant material produced from Lactobacillus plantarum ...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29673838/piezoelectric-materials-as-stimulatory-biomedical-materials-and-scaffolds-for-bone-repair
#16
REVIEW
Biranche Tandon, Jonny J Blaker, Sarah H Cartmell
The process of bone repair and regeneration requires multiple physiological cues including biochemical, electrical and mechanical - that act together to ensure functional recovery. Myriad materials have been explored as bioactive scaffolds to deliver these cues locally to the damage site, amongst these piezoelectric materials have demonstrated significant potential for tissue engineering and regeneration, especially for bone repair. Piezoelectric materials have been widely explored for power generation and harvesting, structural health monitoring, and use in biomedical devices...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29672974/inhibition-of-uvb-induced-pro-inflammatory-cytokines-and-mmp-expression-by-zanthoxylum-rhetsa-bark-extract-and-its-active-constituent-hesperidin
#17
Ramesh Kumar Santhanam, Sharida Fakurazi, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari
The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions of different polarity obtained from the methanolic extract of the bark material were initially tested for anticollagenase and antielastase activities. The ethyl acetate fraction showed bioactivity against the protease enzymes. Hence, it was subjected to further purification via column chromatography, to yield a major constituent, hesperidin. Subsequently, the ethyl acetate fraction and hesperidin were tested for their effects against UVB-induced cytotoxicity and expressions of inflammatory cytokines (IL-6, IL-1β, and TNF-α), NF-κB, and MMPs (MMP1, 3, and 9) in human dermal fibroblasts (HDF)...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29670960/application-of-far-infrared-spectroscopy-to-the-structural-identification-of-protein-materials
#18
Yanchen Han, Shengjie Ling, Zeming Qi, Zhengzhong Shao, Xin Chen
Although far-infrared (IR) spectroscopy has been shown to be a powerful tool to determine peptide structure and to detect structural transitions in peptides, it has been overlooked in the characterization of proteins. Herein, we used far-IR spectroscopy to monitor the structure of four abundant non-bioactive proteins, namely, soybean protein isolate (SPI), pea protein isolate (PPI) and two types of silk fibroins (SFs), domestic Bombyx mori and wild Antheraea pernyi. The two globular proteins SPI and PPI result in broad and weak far-IR bands (between 50 and 700 cm-1), in agreement with those of some other bioactive globular proteins previously studied (lysozyme, myoglobin, hemoglobin, etc...
April 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29667511/development-of-coaxial-alginate-pcl-nanofibrous-dressing-for-controlled-release-of-spirulina-extract
#19
Min Sik Kim, Hye Jin Kim, Jin Young Jang, Hwa Sung Shin
of bioactive material that can be impregnated into dressing materials. The aim of this stud Spirulina has widely been highlighted as a source y was to widen the application fields of Spirulina extract-containing nanofiber, which has been suggested as an attractive dressing material in several previous studies. The bioactivity release pattern, water absorbance, and mechanical strength must be controllable. Spirulina extract was physically impregnated inside a nanofiber without significant chemical bonding to polycaprolactone or alginate polymers...
April 18, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29666513/bioactive-compounds-and-in-vitro-antioxidant-activity-of-some-traditional-and-non-traditional-cold-pressed-edible-oils-from-macedonia
#20
Sanja Kostadinović Veličkovska, Augustin Catalin Moţ, Saša Mitrev, Rubin Gulaboski, Ludger Brühl, Hamed Mirhosseini, Radu Silaghi-Dumitrescu, Bertrand Matthäus
The bioactive compounds and "in vitro" antioxidant activity measured by three antioxidant assays of some traditional and non-traditional cold-pressed edible oils from Macedonia were object of this study. The fatty acid composition showed dominance of monounsaturated oleic acid in "sweet" and "bitter" apricot kernel oils with percentages of 66.7 ± 0.5 and 57.8 ± 0.3%, respectively. The most dominant fatty acid in paprika seed oil was polyunsaturated linoleic acid with abundance of 69...
May 2018: Journal of Food Science and Technology
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