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https://www.readbyqxmd.com/read/29457695/functionalization-of-a-nanostructured-hydroxyapatite-with-copper-ii-compounds-as-pesticide-in-situ-tem-and-esem-observations-of-treated-vitis-vinifera-l-leaves
#1
Enrico Battiston, Maria C Salvatici, Alessandro Lavacchi, Antonietta Gatti, Stefano Di Marco, Laura Mugnai
BACKGROUND: The present study evaluates a biocompatible material for plant protection to reduce the amount of active substance applied. We used a synthetic hydroxyapatite (HA) that has been studied extensively due its bioactivity and biocompatibility. Aggregation between HA nanoparticles and four copper(II) compounds applied in Vitis vinifera L. leaves as pesticide was studied. Formulations were characterised by XRD, DLS, electron microscopy and applied in planta to verify the particle aggregation and efficiency in controlling the pathogen, Plasmopara viticola...
February 19, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29457442/-development-and-application-of-artificial-vertebral-body
#2
REVIEW
Jian-Tao Liu, Feng Zhang, Zheng-Chao Gao, Bin-Bin Niu, Yu-Huan Li, Xi-Jing He
Artificial vertebral body has achieved good results in treating spinal tumors, tuberculosis, fracture and other diseases. Currently, artificial vertebral body with variety of kinds and pros and cons, is generally divided into two types: fusion type and movable type. The former according to whether the height could be adjusted and strength of self-stability is divided into three types: support-fixed type, adjust-fixed type and self-fixed type. Whether the height of self-fixed type could be adjusted is dependent on structure of collar thread rotation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29456294/cobalt-containing-bioactive-glasses-reduce-human-mesenchymal-stem-cell-chondrogenic-differentiation-despite-hif-1%C3%AE-stabilisation
#3
E Littmann, H Autefage, A K Solanki, C Kallepitis, J R Jones, M Alini, M Peroglio, M M Stevens
Bioactive glasses (BGs) are excellent delivery systems for the sustained release of therapeutic ions and have been extensively studied in the context of bone tissue engineering. More recently, due to their osteogenic properties and expanding application to soft tissue repair, BGs have been proposed as promising materials for use at the osteochondral interface. Since hypoxia plays a critical role during cartilage formation, we sought to investigate the influence of BGs releasing the hypoxia-mimicking agent cobalt (CoBGs) on human mesenchymal stem cell (hMSC) chondrogenesis, as a novel approach that may guide future osteochondral scaffold design...
March 2018: Journal of the European Ceramic Society
https://www.readbyqxmd.com/read/29456275/antimicrobial-packaging-based-on-%C3%A9-polylysine-bioactive-film-for-the-control-of-mycotoxigenic-fungi-in-vitro-and-in-bread
#4
C Luz, J Calpe, F Saladino, Fernando B Luciano, M Fernandez-Franzón, J Mañes, G Meca
ɛ-Poly-l-lysine (ɛ-PL) is a cationic peptide with a broad-spectrum antimicrobial activity. This study investigates the use of ɛ-PL as natural antimicrobial to inhibit fungal growth and to reduce aflatoxins (AFs) production. Antifungal activity of starch biofilms with different concentrations of ɛ-Poly-l-lysine (ɛ-PL) was determined in solid medium against Aspergillus parasiticus (AFs producer) and Penicillium expansum . Then, biofilms were tested as antimicrobial devices for the preservation of bread loaf inoculated with A...
January 2018: Journal of Food Processing and Preservation
https://www.readbyqxmd.com/read/29451421/bionanocomposite-scaffolds-based-on-chitosan-gelatin-and-nanodimensional-bioactive-glass-particles-in-vitro-properties-and-in-vivo-bone-regeneration
#5
Cristian Covarrubias, Monserrat Cádiz, Miguel Maureira, Isabel Celhay, Felipe Cuadra, Alfredo von Marttens
Bone repair bionanocomposite scaffolds were produced by incorporating dense bioactive glass nanoparticles or mesoporous bioactive glass nanospheres into a chitosan-gelatin polymer blend. The in vitro bioactivity of the scaffolds was assessed in simulated body fluid, and cell viability and osteogenic differentiation assays were performed with dental pulp stem cells. Bone regeneration properties of the scaffold materials were in vivo assessed by using a critical-sized femoral defect model in rat. The scaffold nanocomposites showed excellent cytocompatibility and ability to accelerate the crystallization of bone-like apatite in vitro...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29450831/comparison-of-different-strategies-for-providing-fecal-microbiota-transplantation-to-treat-patients-with-recurrent-clostridium-difficile-infection-in-two-english-hospitals-a-review
#6
REVIEW
Simon D Goldenberg, Rahul Batra, Ian Beales, Jonathan Leith Digby-Bell, Peter Miles Irving, Lee Kellingray, Arjan Narbad, Ngozi Franslem-Elumogo
Fecal microbiota transplant (FMT) has emerged as a highly efficacious treatment for difficult cases of refractory and/or recurrent Clostridium difficile infection (CDI). There have been many well-conducted randomized controlled trials and thousands of patients reported in case series that describe success rates of approximately 90% following one or more FMT. Although the exact mechanisms of FMT have yet to be fully elucidated, replacement or restoration of a 'normal' microbiota (or at least a microbiota resembling those who have never had CDI) appears to have a positive effect on the gut dysbiosis that is thought to exist in these patients...
February 15, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29448144/nanocements-produced-from-mesoporous-bioactive-glass-nanoparticles
#7
Min Sil Kang, Na-Hyun Lee, Rajendra K Singh, Nandin Mandakhbayar, Roman A Perez, Jung-Hwan Lee, Hae-Won Kim
Biomedical cements are considered promising injectable materials for bone repair and regeneration. Calcium phosphate composition sized with tens of micrometers is currently one of the major powder forms. Here we report a unique cement form made from mesoporous bioactive glass nanoparticles (BGn). The nanopowder could harden in reaction with aqueous solution at powder-to-liquid ratios as low as 0.4-0.5 (vs. 2.0-3.0 for conventional calcium phosphate cement CPC). The cementation mechanism investigated from TEM, XRD, FT-IR, XPS, and NMR analyses was demonstrated to be the ionic (Si and Ca) dissolution and then reprecipitation to form Si-Ca-(P) based amorphous nano-islands that could network the particles...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29447978/the-influence-of-procyanidins-isolated-from-small-leaved-lime-flowers-tilia-cordata-mill-on-human-neutrophils
#8
Monika E Czerwińska, Marta K Dudek, Karolina A Pawłowska, Anna Pruś, Maria Ziaja, Sebastian Granica
Linden flower is a wildly used plant material among patients in the treatment of common cold symptoms and mucosa inflammations. However, the structure and bioactivity of flavan-3-ol derivatives present in infusions from flowers of Tilia cordata have not been studied so far. The aim of current study was to isolate and identify main procyanidins present in the flowers of small-leaved lime and to evaluate their influence on the inflammatory response of human neutrophils ex vivo. The chemical structure of isolated compounds was established by 1D and 2D NMR experiments...
February 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29446542/novel-calcitonin-gene-related-peptide-chitosan-strontium-calcium-phosphate-cement-enhanced-proliferation-of-human-umbilical-vein-endothelial-cells-in-vitro
#9
Tiancheng Lv, Wei Liang, Li Li, Xu Cui, Xiaomou Wei, Haobo Pan, Bing Li
Bone cement materials have some disadvantages, including slow degradation and no biological activity, which greatly weakens their clinical application. Therefore, the search for a multifunctional bioactive bone cement has become urgent. In this study, a novel bone cement sample of calcitonin gene-related peptide (CGRP)/chitosan-strontium (Sr)-calcium phosphate cement (CPC) was developed. The structure and morphology were observed by scanning electron microscope (SEM). The cytotoxicity and proliferation of CGRP/chitosan-Sr-CPC were also measured...
February 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29446077/coffee-drinking-and-colorectal-cancer-and-its-subsites-a-pooled-analysis-of-8-cohort-studies-in-japan
#10
Ikuko Kashino, Shamima Akter, Tetsuya Mizoue, Norie Sawada, Ayaka Kotemori, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Tomio Nakayama, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Manami Inoue, Chisato Nagata, Atsuko Sadakane, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
Coffee is a rich source of bioactive compounds that have potential anti-carcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,276 person-years, 6,711 incident colorectal cancer cases were identified...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29446015/synthetic-polymeric-biomaterials-for-wound-healing-a-review
#11
Mariam Mir, Murtaza Najabat Ali, Afifa Barakullah, Ayesha Gulzar, Munam Arshad, Shizza Fatima, Maliha Asad
Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the 'one size fits all approach', if it conforms strictly to the specifications of the wound and the patient...
February 14, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29445894/sparse-qsar-modelling-methods-for-therapeutic-and-regenerative-medicine
#12
David A Winkler
The quantitative structure-activity relationships method was popularized by Hansch and Fujita over 50 years ago. The usefulness of the method for drug design and development has been shown in the intervening years. As it was developed initially to elucidate which molecular properties modulated the relative potency of putative agrochemicals, and at a time when computing resources were scarce, there is much scope for applying modern mathematical methods to improve the QSAR method and to extending the general concept to the discovery and optimization of bioactive molecules and materials more broadly...
February 14, 2018: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29443426/comprehensive-investigation-into-the-interconversion-of-c-2-diastereomers-of-naringin
#13
Hongliang Yao, Weiwei Su, Linhuo Lin, Wenjun Pan, Xuan Zeng, Panlin Li
Naringin is a flavanone that widely presents on daily diet and traditional medicinal materials. The ratios of naringin C-2 diastereomers are found different in reported samples, thus suspiciously leading to various functions. In this study, we measured the interconversion of C-2 diastereomers intensively with ultimate high-performance liquid chromatography and circular dichroism spectra. We examined the diastereomeric naringins in fresh citrus fruit, Huajuhong decoction pieces, and naringin tablet; evaluated the impact of tablet production procedures in factory; and monitored the rapid racemization in incubation...
February 14, 2018: Chirality
https://www.readbyqxmd.com/read/29442812/tea-polyphenol-reduced-graphene-oxide-deposition-on-titanium-surface-enhances-osteoblast-bioactivity
#14
Mengting Liu, Liying Hao, Qian Huang, Dan Zhao, Qianshun Li, Xiaoxiao Cai
Graphene, a novel carbon-based material, has been widely used as osteogenic agent for the potential effect on the promotion of osteoblast proliferation. Tea polyphenol-reduced graphene oxide (TPG) is a simple and environmental-friendly raw material to obtain graphene. In this study, TPG was deposited on the Ti substrate to promote the bone regeneration. We prepared a honeycomb-like structure by acid and alkali pretreatment and immobilized the TPG layer (Ti-TPG) on the surface via electrochemical deposition...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442653/effect-of-titania-concentration-in-bioglass-tio%C3%A2-nanostructures-and-its-in-vitro-biological-property-assessment
#15
P Bargavi, S Chitra, D Durgalakshmi, P Rajashree, S Balakumar
Bioglass 45S5 (45% SiO2-24.5% NaO-24.5% CaO-6% P2O5) is a unique bioactive material, which is being used for bone and dental substitution. This system has been highly preferred for its osteoconductive and osteoinductive performance. Despite its attractive bioactivity, there are limitations in using this material for orthopedic and dental applications due to its poor processability and mechanical strength. To improve the load-sharing and stress distribution, TiO2 nanoparticles have been introduced into the nanoBioglass (nBG) by sol-gel method...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439370/the-biomechanical-analysis-of-three-dimensional-distal-radius-fracture-model-with-different-fixed-splints
#16
Zhen Hua, Jian-Wei Wang, Zhen-Fei Lu, Jian-Wei Ma, Heng Yin
BACKGROUND: The distal radius fracture is one of the common clinical fractures. At present, there are no reports regarding application of the finite element method in studying the mechanism of Colles fracture and the biomechanical behavior when using splint fixation. OBJECTIVE: To explore the mechanism of Colles fracture and the biomechanical behavior when using different fixed splints. METHODS: Based on the CT scanning images of forearm for a young female volunteer, by using model construction technology combined with RPOE and ANSYS software, a 3-D distal radius fracture forearm finite element model with a real shape and bioactive materials is built...
January 30, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29438617/construction-of-bioactive-and-reinforced-bioresorbable-nanocomposites-by-reduced-nano-graphene-oxide-carbon-dots
#17
Nejla B Erdal, Minna Hakkarainen
Bioactive and reinforced poly(ε-caprolactone) (PCL) films were constructed by incorporation of cellulose derived reduced nano-graphene oxide (r-nGO) carbon nanodots. Two different microwave-assisted reduction routes in superheated water were utilized to obtain r-nGO and r-nGO-CA. For the latter a green reducing agent, caffeic acid (CA) was incorporated in the reduction process. The materials were extruded and compression molded to obtain proper dispersion of the carbon nanodots in the polymer matrix. FTIR results revealed favorable interactions between r-nGO-CA and PCL that improved the dispersion of r-nGO-CA...
February 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29437383/encoding-stem-cell-secreted-extracellular-matrix-protein-capture-in-two-and-three-dimensions-using-protein-binding-peptides
#18
Hadi Hezaveh, Steffen Cosson, Ellen A Otte, Guannan Su, Benjamin D Fairbanks, Justin J Cooper-White
Capturing cell-secreted extracellular matrix (ECM) proteins through cooperative binding with high specificity and affinity is an important function of native tissue matrices during both tissue homeostasis and repair. However, whilst synthetic hydrogels, such as those based on polyethylene glycol (PEG), are often proposed as ideal materials to deliver human mesenchymal stem cells (hMSCs) to sites of injury to enable tissue repair, they do not have this capability, a capability that would enable cells to actively remodel their local extracellular microenvironment and potentially provide the required feedback control for more effective tissue genesis...
February 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29433291/stability-of-lime-essential-oil-microparticles-produced-with-protein-carbohydrate-blends
#19
Pedro Henrique Campelo, Edgar Aparecido Sanches, Regiane Victória de Barros Fernandes, Diego Alvarenga Botrel, Soraia Vilela Borges
The objective of this work was to analyze the influence of maltodextrin equivalent dextrose on the lime essential oil reconstitution, storage, release and protection properties. Four treatments were evaluated: whey protein concentrate (WPC), and blends of maltodextrin with dextrose equivalents of 5 (WM5), 10 (WM10) and 20 (WM20). The reconstitution and storage properties of the microparticles (solubility, wettability and density), water kinetics adsorption, sorption isotherms, thermogravimetric properties, controlled release and degradation kinetics of encapsulated lime essential oil were studied to measure the quality of the encapsulated materials...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433212/application-of-microencapsulation-for-the-safe-delivery-of-green-tea-polyphenols-in-food-systems-review-and-recent-advances
#20
REVIEW
Awa Fanny Massounga Bora, Shaojie Ma, Xiaodong Li, Lu Liu
Green tea has been associated with the prevention and reduction of a wide range of severe health conditions such as cancer, immune, and cardiovascular diseases. The health benefits associated with green tea consumption have been predominantly attributed to green tea polyphenols. The functional properties of green tea polyphenols are mainly anti-oxidative, antimutagenic, anticarcinogenic, anti-microbial, etc. These excellent properties have recently gained considerable attention in the food industry. However, their application is limited by their sensitivity to factors like temperature, light, pH, oxygen, etc...
March 2018: Food Research International
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