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https://www.readbyqxmd.com/read/28719860/liposome-modified-titanium-surface-a-strategy-to-locally-deliver-bioactive-molecules
#1
Vincenzo De Leo, Monica Mattioli-Belmonte, Maria Teresa Cimmarusti, Annamaria Panniello, Manuela Dicarlo, Francesco Milano, Angela Agostiano, Elvira De Giglio, Lucia Catucci
Titanium and its alloys are widely employed materials for implants in orthopedic or dental surgery due to their mechanical properties, resistance to corrosion and osseointegration capability. However adverse reactions at the tissue/implant interface may occur, which limit the success of the osseointegration process. Therefore, different strategies have to be used to overcome these drawbacks. In this work, we developed two different liposome-based coatings on titanium surfaces as drug or bioactive molecule deposits for dental/orthopedic implant applications...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28718680/development-of-emu-oil-loaded-pcl-collagen-bioactive-nanofibers-for-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cell-possible-application-in-regenerative-medicine
#2
Kazem Nejati-Koshki, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Abbas Ebrahimi-Kalan, Yousef Mortazavi, Nosratollah Zarghami
Adipose tissue-derived stem cells (ASCs) are promising candidate in stem cell therapies, and maintaining their stemness potential is vital to achieve effective treatment. Natural based scaffolds have been recently attracted increasing attention in nanomedicine and drug delivery. In the present study, a polymeric nanofibrous scaffold was developed based on the polycaprolactone/Collagen (PCL/Coll) containing Emu oil as a bioactive material to induce the proliferation of ASCs, while simultaneously preserve the stemness property of those cells...
July 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28714329/synthetic-sutures-clinical-evaluation-and-future-developments
#3
Roxanna E Abhari, Joana A Martins, Hayley L Morris, Pierre-Alexis Mouthuy, Andrew Carr
Today's sutures are the result of a 4000-year innovation process with regard to their materials and manufacturing techniques, yet little has been done to enhance the therapeutic value of the suture itself. In this review, we explore the historical development, regulatory database and clinical literature of sutures to gain a fuller picture of suture advances to date. First, we examine historical shifts in suture manufacturing companies and review suture regulatory databases to understand the forces driving suture development...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28707617/supercritical-fluid-extraction-of-bioactive-compounds-from-plant-materials
#4
Olga Wrona, Katarzyna Rafińska, Cezary Możeński, Bogusław Buszewski
There has been growing interest in the application of supercritical solvents over the last several years, manyof the applications industrial in nature. The purpose of plant material extraction is to obtain large amounts of extract rich in the desired active compounds in a time-sensitive and cost-effective manner. The productivity and profitability of a supercritical fluid extraction (SFE) process largely depends on the selection of process parameters, which are elaborated upon in this paper. Carbon dioxide (CO₂) is the most desirable solvent for the supercritical extraction of natural products...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28706274/elovanoids-are-novel-cell-specific-lipid-mediators-necessary-for-neuroprotective-signaling-for-photoreceptor-cell-integrity
#5
Bokkyoo Jun, Pranab K Mukherjee, Aram Asatryan, Marie-Audrey Kautzmann, Jessica Heap, William C Gordon, Surjyadipta Bhattacharjee, Rong Yang, Nicos A Petasis, Nicolas G Bazan
Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (≥C28) polyunsaturated fatty acids including n-3 (VLC-PUFAs,n-3). While ELOVL4 mutations are linked to vision loss and neuronal dysfunctions, the roles of VLC-PUFAs remain unknown. Here we report a novel class of lipid mediators biosynthesized in human retinal pigment epithelial (RPE) cells that are oxygenated derivatives of VLC-PUFAs,n-3; we termed these mediators elovanoids (ELV)...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706151/osteoblast-oriented-differentiation-of-bmscs-by-co-culturing-with-composite-scaffolds-constructed-using-silicon-substituted-calcium-phosphate-autogenous-fine-particulate-bone-powder-and-alginate-in-vitro
#6
Ye Tian, Li-Huang Cui, Shou-Yang Xiang, Wen-Xiao Xu, De-Chun Chen, Rui Fu, Chang-Long Zhou, Xiao-Qi Liu, Yu-Fu Wang, Xin-Tao Wang
Autogenous bone graft is the best for spinal fusion in clinics, however, lacking sources, bleeding and infection are limited its practice. Seeking alternative materials are urgent for orthopaedic surgeon. Here, we evaluated osteoblast-oriented differentiation of rabbit BMSCs by co-culturing with composite scaffolds constructed using silicon-substituted-CaP-fine particulate bone powder-alginate. Using CCk8-kit, biocompatibility was evaluated by testing BMSCs proliferation; morphology and survival of osteoblasts within scaffolds were observed using EM and HE staining; growth factors and related genes were detected using RT-PCR...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699748/next-generation-hemostatic-materials-based-on-nhs-ester-functionalized-poly-2-oxazoline-s
#7
Marcel A Boerman, Edwin Roozen, Maria Jose Sánchez-Fernández, Abraham R Keereweer, Rosa P Felix Lanao, Johan C M E Bender, Richard Hoogenboom, Sander C G Leeuwenburgh, John A Jansen, Harry van Goor, Jan C M van Hest
In order to prevent hemorrhage during surgical procedures, a wide range of hemostatic agents have been developed. However, their efficacy is variable; hemostatic devices that use bioactive components to accelerate coagulation are dependent on natural sources, which limits reproducibility. Hybrid devices in which chain-end reactive poly(ethylene glycol) is employed as active component sometimes suffer from irregular crosslinking and/or dissolution of the polar PEG when blood flow is substantial. Herein, we describe a synthetic, non-bioactive hemostatic product by coating N-hydroxysuccinimide ester (NHS)-functional poly(2-oxazoline)s (POx-NHS) onto gelatin patches, which acts by formation of covalent crosslinks between polymer, host blood proteins, gelatin and tissue to seal the wound site and prevent hemorrhage during surgery...
July 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28697772/injectable-and-compression-resistant-low-viscosity-polymer-ceramic-composite-carriers-for-rhbmp-2-in-a-rabbit-model-of-posterolateral-fusion-a-pilot-study
#8
Stefanie M Shiels, Anne D Talley, Madison A P McGough, Katarzyna J Zienkiewicz, Kerem Kalpakci, Daniel Shimko, Scott A Guelcher, Joseph C Wenke
BACKGROUND: The challenging biological and mechanical environment of posterolateral fusion (PLF) requires a carrier that spans the transverse processes and resists the compressive forces of the posterior musculature. The less traumatic posterolateral approach enabled by minimally invasive surgical techniques has prompted investigations into alternative rhBMP-2 carriers that are injectable, settable, and compression-resistant. In this pilot study, we investigated injectable low-viscosity (LV) polymer/composite bone grafts as compression-resistant carriers for rhBMP-2 in a single-level rabbit PLF model...
July 11, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28696091/enhanced-osseointegration-of-porous-titanium-modified-with-zeolitic-imidazolate-framework-8
#9
Xin Zhang, Junyu Chen, Xiang Pei, Jian Wang, Qianbing Wan, Shaokang Jiang, Chao Huang, Xibo Pei
Nanoscale zeolitic imidazolate framework-8 (ZIF-8)-modified titanium (ZIF-8@AHT) can enhance osteogenesis in vitro. In this study, we systematically and quantitatively examined the effects of ZIF-8@AHT on osteogenesis, and investigated its ability to form bone in vivo. First, we coated various quantities of nanoscale ZIF-8 crystals on alkali- and heat-treated titanium (AHT) by controlling the concentration of the synthesis solution. We then characterized the ZIF-8@AHT materials using scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), and determination of the sessile drop contact angle...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28695450/biofunctionalization-of-porcine-derived-collagen-matrix-using-enamel-matrix-derivative-and-platelet-rich-fibrin-influence-on-mature-endothelial-cell-characteristics-in-vitro
#10
Jung Soo Park, Andreas Max Pabst, Maximilian Ackermann, Maximilian Moergel, Junho Jung, Adrian Kasaj
OBJECTIVES: The present study evaluated the effect of an enamel matrix derivative (EMD) and platelet-rich fibrin (PRF)-modified porcine-derived collagen matrix (PDCM) on human umbilical vein endothelial cells (HUVEC) in vitro. MATERIALS AND METHODS: PDCM (mucoderm®) was prepared to 6 mm (±0.1 mm) diameter discs. PDCM samples were incubated with either EMD, PRF, or control solutions for 100 min at 4 °C before the experiments. Cell-inducing properties of test materials on HUVEC cells were tested with cell proliferation assays (MTT, PrestoBlue®), a cytotoxicity assay (ToxiLight®), a Boyden chamber migration assay, and a cell attachment assay...
July 11, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28693863/effect-of-ultrasound-treatment-during-osmotic-dehydration-on-bioactive-compounds-of-cranberries
#11
Malgorzata Nowacka, Aleksandra Fijalkowska, Magdalena Dadan, Katarzyna Rybak, Artur Wiktor, Dorota Witrowa-Rajchert
The aim of the study was to investigate the influence of ultrasound treatment applied in osmotic solution on bioactive compounds, such as vitamin C, polyphenols, anthocyanins and flavonoids content as well as antioxidant activity in cranberries (Vaccinium oxycoccus). Ultrasound treatment was performed at the frequency of 21kHz for 30 and 60min in two osmotic solutions - 61.5% sucrose and 30% sucrose with an addition of 0.1% of steviol glycosides. Before the ultrasound treatment the material was subjected to cutting or blanching...
July 1, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28691448/evaluation-of-chemical-physical-properties-and-cytocompatibility-of-theracal-lc
#12
A Buonavoglia, D Lauritano, D Perrone, F Ardito, G Troiano, M Dioguardi, V Candotto, F J Silvestre, L Lo Muzio
TheraCal LC (TLC, Bisco Inc., Schaumburg, IL, USA) is a light-cured, resin-modified, calcium silicate-filled base/liner material designed for direct and indirect pulp-capping. In this study the result of the evaluation in vitro of the biocompatibility and chemical-physical properties of TLC are reported. TLC specimens were prepared under aseptic conditions in strict compliance with the manufacturer’s instructions and sterilized. Osteoblast-like cells (MG63) were used. For different time points, solubility, water uptake, alkalinizing activity and cytotoxicity were evaluated...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28688047/assessment-of-antioxidant-and-antimicrobial-properties-of-lignin-from-corn-stover-residue-pretreated-with-low-moisture-anhydrous-ammonia-and-enzymatic-hydrolysis-process
#13
Mingming Guo, Tony Jin, Nhuan P Nghiem, Xuetong Fan, Phoebe X Qi, Chan Ho Jang, Lingxiao Shao, Changqing Wu
Lignin accounts for 15-35% of dry biomass materials. Therefore, developing value-added co-products from lignin residues is increasingly important to improve the economic viability of biofuel production from biomass resources. The main objective of this work was to study the lignin extracts from corn stover residue obtained from a new and improved process for bioethanol production. Extraction conditions that favored high lignin yield were optimized, and antioxidant and antimicrobial activities of the resulting lignin were investigated...
July 7, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28687393/a-promising-wound-dressing-material-with-excellent-cytocompatibility-and-proangiogenesis-action-for-wound-healing-strontium-loaded-silk-fibroin-sodium-alginate-sf-sa-blend-films
#14
Shuangshuang Li, Li Li, Chengrui Guo, Huanhuan Qin, Xixun Yu
Effectively stimulating angiogenesis is great challenge in wound care management. It's necessary to develop a new wound dressing with angiogenic capacity. Therefore, strontium loaded SF/SA blend films were prepared as a potential wound dressing material, and their physicochemical and bioactive properties were evaluated. The strontium loaded SF/SA blend films (especially the strontium loaded SF/SA blend films prepared by treating with 5mg/ml Sir solution) could meet the needs of a wound dressing such as water absorption, water vapor transmission rate, mechanical properties and fibroblasts-cytocompatibility...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28687391/using-a-bacterial-fucose-rich-polysaccharide-as-encapsulation-material-of-bioactive-compounds
#15
Sofia C Lourenço, Cristiana A V Torres, Daniela Nunes, Paulo Duarte, Filomena Freitas, Maria A M Reis, Elvira Fortunato, Margarida Moldão-Martins, Luísa Beirão da Costa, Vítor D Alves
The potential of a bacterial exopolysaccharide named FucoPol, produced by the bacterium Enterobacter A47, as encapsulation matrix was explored. Spherical capsules with a smooth surface were produced by spray drying. The obtained microcapsules had average diameters ranging from 0.5 to 26.7μm and presented thin walls (thickness from 222 to 1094nm). The capsules were loaded with two bioactive compounds: gallic acid (GA) and oregano essential oil (OEO). Both bioactive materials were encapsulated in FucoPol particles, retaining their antioxidant activity after the drying process...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28686210/effects-of-titanium-mesh-surfaces-coated-with-hydroxyapatite-%C3%AE-tricalcium-phosphate-nanotubes-on-acetabular-bone-defects-in-rabbits
#16
Thuy-Duong Thi Nguyen, Tae-Sung Bae, Dae-Hyeok Yang, Myung-Sik Park, Sun-Jung Yoon
The management of severe acetabular bone defects in revision reconstructive orthopedic surgery is challenging. In this study, cyclic precalcification (CP) treatment was used on both nanotube-surface Ti-mesh and a bone graft substitute for the acetabular defect model, and its effects were assessed in vitro and in vivo. Nanotube-Ti mesh coated with hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) was manufactured by an anodizing and a sintering method, respectively. An 8 mm diameter defect was created on each acetabulum of eight rabbits, then treated by grafting materials and covered by Ti meshes...
July 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28686004/bioglass%C3%A2-45s5-based-composites-for-bone-tissue-engineering-and-functional-applications
#17
REVIEW
M Rizwan, M Hamdi, W J Basirun
Bioglass® 45S5 (BG) has an outstanding ability to bond with bones and soft tissues, but its application as a load-bearing scaffold material is restricted due to its inherent brittleness. BG-based composites combine the amazing biological and bioactive characteristics of BG with structural and functional features of other materials. This paper reviews the composites of Bioglass(®) in combination with metals, ceramics and polymers for a wide range of potential applications from bone scaffolds to nerve regeneration...
July 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28684351/effectiveness-of-chitosan-scaffold-in-skin-bone-and-cartilage-healing
#18
REVIEW
Ahmad Oryan, Sonia Sahvieh
Chitosan (CS) is a carbohydrate biopolymer, which has been known as a biological material in promoting the healing process of soft and hard connective tissues. It is biocompatible, biodegradable, bioactive, non-toxic, non-expensive and non-immunogenic, with antibacterial capability. Additionally, the capacity of forming complexes with other anionic biomaterials and molecules offers CS the characteristics to be used in biomedical applications. Therefore, this natural polysaccharide has widely been used as a wound dressing and in bone and cartilage regeneration because of these considerable properties...
July 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28682613/synthesis-of-a-3-amino-2-3-dihydropyrid-4-one-and-related-heterocyclic-analogs-as-mechanism-based-inhibitors-of-bioa-a-pyridoxal-phosphate-plp-dependent-enzyme
#19
Carter G Eiden, Courtney C Aldrich
Amiclenomycin (ACM) is a chemically unstable antibiotic with selective activity against Mycobacterium tuberculosis (Mtb) due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase that catalyzes the second step of biotin biosynthesis. The first-generation ACM analogue dihydro-2-pyridone 1 is semi-stable and maintains a similar bioactivation mechanism concluding with covalent labeling of the PLP cofactor. To improve on 1, we report the synthesis of dihydro-4-pyranone 2, dihydro-4-pyridone 3 and dihydro-4-thiopyranone 13...
July 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28680802/lobster-processing-by-products-as-valuable-bioresource-of-marine-functional-ingredients-nutraceuticals-and-pharmaceuticals
#20
REVIEW
Trung T Nguyen, Andrew R Barber, Kendall Corbin, Wei Zhang
The worldwide annual production of lobster was 165,367 tons valued over $3.32 billion in 2004, but this figure rose up to 304,000 tons in 2012. Over half the volume of the worldwide lobster production has been processed to meet the rising global demand in diversified lobster products. Lobster processing generates a large amount of by-products (heads, shells, livers, and eggs) which account for 50-70% of the starting material. Continued production of these lobster processing by-products (LPBs) without corresponding process development for efficient utilization has led to disposal issues associated with costs and pollutions...
2017: Bioresources and Bioprocessing
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