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https://www.readbyqxmd.com/read/29244726/potential-of-bioactive-glasses-for-cardiac-and-pulmonary-tissue-engineering
#1
REVIEW
Saeid Kargozar, Sepideh Hamzehlou, Francesco Baino
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29243484/nanopatterns-of-surface-bound-ephrinb1-produce-multivalent-ligand-receptor-interactions-that-tune-ephb2-receptor-clustering
#2
Verónica Hortigüela, Enara Larrañaga, Francesco Cutrale, Anna Seriola, María García-Díaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Martinez
Here we present a nanostructured surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors. We created ephrinB1 nanopatterns of regular size (<30 nm in diameter) by using self-assembled diblock copolymers. Next, we used a statistically enhanced version of the Number and Brightness technique, which can discriminate - with molecular sensitivity - the oligomeric states of diffusive species to quantitatively track the EphB2 receptor oligomerization process in real time...
December 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29241052/hydroxyapatite-chitosan-based-bioactive-hybrid-biomaterials-with-improved-mechanical-strength
#3
A Zima
Composites consisting of hydroxyapatite (HA) and chitosan (CTS) have recently been intensively studied. In this work, a novel inorganic-organic (I/O) HA/CTS materials in the form of granules were prepared through a simple solution-based chemical method. During the synthesis of these hybrids, the electrostatic complexes between positively charged, protonated amine groups of chitosan and the negative phosphate species (HPO42- and H2PO4-) were formed. Our biocomposites belong to the class I of hybrids, which was confirmed by FTIR studies...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29240236/evaluation-of-osteoblast-differentiation-and-function-when-cultured-on-mesoporous-bioactive-glass-adsorbed-with-testosterone
#4
Kai Gao, Xiaoyan Wang, Qianqian Liu, Wei Chen, Gan Wang, Dongyi Zhang, Long Liu
Mesoporous bioactive glass (MBG), a kind of porous materials with great osteoconductive and osteoinductive ability, shows promising application in bone tissue engineering due to its high specific surface area, orderly channel structure and large pore volume. Here we reported that the proliferation, differentiation and mineralization were promoted in MC3T3-E1 cells cultured on MBG which adsorbed with testosterone (MBG/T). We found that transcriptional activity of Runx2 which is a critical transcription factor is increased in MC3T3-E1 cells cultured on MBG/T...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236677/a-chemometrics-approach-for-nuclear-magnetic-resonance-data-to-characterize-the-partial-metabolome-banana-peels-from-southern-brazil
#5
Sara Cardoso, Marcelo Maraschin, Luiz Augusto Martins Peruch, Miguel Rocha, Aline Pereira
Banana peels are well recognized as a source of important bioactive compounds, such as phenolics, carotenoids, biogenic amines, among others. As such, they have recently started to be used for industrial purposes. However, its composition seems to be strongly affected by biotic or abiotic ecological factors. Thus, this study aimed to investigate banana peels chemical composition, not only to get insights on eventual metabolic changes caused by the seasons, in southern Brazil, but also to identify the most relevant metabolites for these processes...
December 13, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29236498/enhancement-of-anti-inflammatory-properties-of-nobiletin-in-macrophages-by-a-nano-emulsion-preparation
#6
Wenzhen Liao, Zhijun Liu, Tiantian Zhang, Suxia Sun, Jufeng Ye, Ziyin Li, Lianzhi Mao, Jiaoyan Ren
Many bioactive compounds are hydrophobic materials that are crystalline at ambient and body temperatures, which reduces their bioavailability and poses challenges to their successful incorporation into pharmaceuticals and functional foods. The aim of this study was to develop a nanoemulsion delivery system containing a hydrophobic crystalline bioactive component (nobiletin) to improve the anti-inflammatory activity. Nobiletin was incorporated into the oily phase, and the nanoemulsions were fabricated using high-speed and high-pressure homogenization...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29236489/magnesium-catalyzed-polymerization-of-end-functionalized-poly-propylene-maleate-and-poly-propylene-fumarate-for-3d-printing-of-bioactive-scaffolds
#7
James A Wilson, Derek Luong, Alex P Kleinfehn, Sahar Sallam, Chrys Wesdemiotis, Matthew L Becker
The ring-opening copolymerization of maleic anhydride and propylene oxide, using a functionalized primary alcohol initiator and magnesium 2,6-di-tert-butyl phenoxide as a catalyst, was investigated in order to produce high end-group fidelity poly(propylene maleate). Subsequent isomerization of the material into 3D printable poly(propylene fumarate) was utilized to produce scaffolds and thin films possessing groups that can be modified post-polymerization and post-printing. The surface concentration of these modifiable groups was determined to be 30...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29236225/enhanced-ultrasound-assisted-enzymatic-hydrolysis-extraction-of-quinolizidine-alkaloids-from-sophora-alopecuroides-l-seeds
#8
Hanqing Wang, Yue Tong, Wei Li, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Jianjun Zhao, Kazuo Koike
Quinolizidine alkaloids are the main bioactive components in Sophora alopecuroides L. This study reports a novel ultrasound-assisted enzymatic hydrolysis method for the extraction of these important alkaloids. Box-Behnken design, a widely used response surface methodology, was used to investigate the effects of process variables on ultrasound bath-assisted enzymatic hydrolysis (UAEH) extraction. Four independent variables, pH, extraction temperature (°C), extraction time (min) and solvent-to-material ratio (mL/g), were studied...
December 13, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29234061/evaluation-of-promoting-effect-of-a-novel-cu-bearing-metal-stent-on-endothelialization-process-from-in-vitro-and-in-vivo-studies
#9
Shujing Jin, Xun Qi, Bin Zhang, Ziqing Sun, Bingchun Zhang, Hui Yang, Tongmin Wang, Bo Zheng, Xingang Wang, Qiuping Shi, Ming Chen, Ling Ren, Ke Yang, Hongshan Zhong
Drug eluting stents (DES) have been extensively applied nowadays and reduce the incidence of in-stent restenosis (ISR) greatly as compared with bare metal stents (BMS). However, the development of DES is hindered by the risk of late stent thrombosis (LST) due to delayed re-endothelialization, while endothelialization is an important process related to ISR and LST after implantation. 316L is a traditional stent material without bioactivity and have a high risk of ISR. Cu is recognized for angiogenesis stimulation in these years...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232643/mechanical-corrosion-and-biocompatibility-behaviour-of-mg-3zn-ha-biodegradable-composites-for-orthopaedic-fixture-accessories
#10
Satish Jaiswal, R Manoj Kumar, Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
Development of biodegradable implants has grown into one of the important areas in medical science. Degradability becomes more important for orthopaedic accessories used to support fractured and damaged bones, in order to avoid second surgery for their removal after healing. Clinically available biodegradable orthopaedic materials are mainly made of polymers or ceramics. These orthopaedic accessories have an unsatisfactory mechanical strength, when used in load-bearing parts. Magnesium and its alloys can be suitable candidate for this purpose, due to their outstanding strength to weight ratio, biodegradability, non-toxicity and mechanical properties, similar to natural bone...
November 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29232074/focus-on-bioactive-dental-materials
#11
Robert A Lowe
No abstract text is available yet for this article.
May 2017: Dentistry Today
https://www.readbyqxmd.com/read/29227635/small-bioactive-peptides-for-biomaterials-design-and-therapeutics
#12
I W Hamley
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, peptide affinity tags, anticancer peptides, and others...
December 11, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29225960/utility-of-amorphous-calcium-phosphate-based-scaffolds-in-dental-biomedical-applications
#13
Diane R Bienek, Drago Skrtic
Calcium phosphate (CaP) materials are important inorganic constituents in biological hard tissue. CaPs, including amorphous calcium phosphate (ACP) have been widely applied in dental and biomedical applications, such as tissue engineering. Scaffold constructs are commonly used as templates to create a biomimetic environment. This review considers ACP scaffold fabrication techniques, including tissue-engineered constructs with intrinsic incorporation of ACP as well as scaffolds formed via precipitation of mineralized solutions on a substrate...
2017: Biointerface Research in Applied Chemistry
https://www.readbyqxmd.com/read/29223071/bioactive-potential-of-silica-coatings-and-its-effect-on-the-adhesion-of-proteins-to-titanium-implants
#14
F Romero-Gavilan, N Araújo-Gomes, A M Sánchez-Pérez, I García-Arnáez, F Elortza, M Azkargorta, J J Martín de Llano, C Carda, M Gurruchaga, J Suay, I Goñi
There is an ever-increasing need to develop dental implants with ideal characteristics to achieve specific and desired biological response in the scope of improve the healing process post-implantation. Following that premise, enhancing and optimizing titanium implants through superficial treatments, like silica sol-gel hybrid coatings, are regarded as a route of future research in this area. These coatings change the physicochemical properties of the implant, ultimately affecting its biological characteristics...
December 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29222431/utilization-of-blood-by-products-an-in-silico-and-experimental-combined-study-for-bsa-usage
#15
Fátima Arrutia, Rebeca Fernández, Carlos Menéndez, Ulises A González, Francisco A Riera
In order to exploit industrial discards, protein enzymatic hydrolysis is a currently popular methodology for obtaining bioactive peptides. However, once released, most promising peptides have to be selected from the mixture. In this work, the suitability of pepsin (EC 3.4.23.1) to hydrolyse serum albumin in order to obtain bioactive peptides was assessed. Then, a suitable process to obtain best separation of bioactive peptides was evaluated, using polyethersulfone membranes at different pH values. Serum albumin was easily hydrolysed by pepsin, reaching a DH value of the 65...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29218244/exosomal-tgf-%C3%AE-1-is-correlated-with-lymphatic-metastasis-of-gastric-cancers
#16
Er-Yen Yen, Shi-Chuen Miaw, Jhang-Sian Yu, I-Rue Lai
Exosomes are nano-vesicles transporting bioactive material between cells. This study explored the prognostic association of exosomal TGF-β1 with lymph node (LN) metastasis of gastric cancer (GC). TGF-β1 expressions in the exosomes isolated from the gastroepiploic veins of 61 GC patients analyzed by ELISA. The regulatory T (Treg) cells in celiac LNs of gastric cancer analyzed by immunohistochemistry. Exosomal TGF-β1 expression and the ratio of Treg cells in draining LNs were both significantly associated with pathological stages and LN metastasis of gastric cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29216567/biocompatible-nanocomposite-of-tio2-incorporated-bi-polymer-for-articular-cartilage-tissue-regeneration-a-facile-material
#17
Lei Cao, Xiaofeng Wu, Qiugen Wang, Jiandong Wang
The development and design of polymeric hydrogels for articular cartilage tissue engineering have been a vital biomedical research for recent days. Organic/inorganic combined hydrogels with improved surface activity have shown potential for the repair and regeneration of hard tissues, but have not been broadly studied for articular cartilage tissue engineering applications. In this work, bi-polymeric hydrogel composite was designed with the incorporation some quantities of stick-like TiO2 nanostructures for favorable surface behavior and enhancement of osteoblast adhesions...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29208986/immune-tuning-scaffold-for-the-local-induction-of-a-pro-regenerative-environment
#18
Bruna Corradetti, Francesca Taraballi, Claudia Corbo, Fernando Cabrera, Laura Pandolfi, Silvia Minardi, Xin Wang, Jeffrey Van Eps, Guillermo Bauza, Bradley Weiner, Ennio Tasciotti
In mammals, tissue regeneration is accomplished through a well-regulated, complex cascade of events. The disruption of the cellular and molecular processes involved in tissue healing might lead to scar formation. Most tissue engineering approaches have tried to improve the regenerative outcome following an injury, through the combination of biocompatible materials, stem cells and bioactive factors. However, implanted materials can cause further healing impairments due to the persistent inflammatory stimuli that trigger the onset of chronic inflammation...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208293/mesoporous-silica-based-bioactive-glasses-for-antibiotic-free-antibacterial-applications
#19
REVIEW
Seray Kaya, Mark Cresswell, Aldo R Boccaccini
Bioactive glasses (BGs) are being used in several biomedical applications, one of them being as antibacterial materials. BGs can be produced via melt-quenching technique or sol-gel method. Bactericidal silver-doped sol-gel derived mesoporous silica-based bioactive glasses were reported for the first time in 2000, having the composition 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore diameter of 28nm. This review paper discusses studies carried out exploring the potential antibacterial applications of drug-free mesoporous silica-based BGs...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29208280/formulation-and-biological-actions-of-nano-bioglass-ceramic-particles-doped-with-calcarea-phosphorica-for-bone-tissue-engineering
#20
S Dinesh Kumar, K Mohamed Abudhahir, N Selvamurugan, S Vimalraj, R Murugesan, N Srinivasan, A Moorthi
The improvisation of the treatment procedures for treating the various kind of bone defects such as, bone or dental trauma and for diseases such as osteoporosis, osteomyelitis etc., need the suitable and promising biomaterials with resemblance of bone components. Bioactive glass ceramic (BGC) has recently acquired great attention as the most promising biomaterials; hence it has been widely applied as a filler material for bone tissue regeneration. Because it elicts specific biological responses after implantation in addition more potential in formation of strong interface with both hard and soft tissues by dissolution of calcium and phosphate ions...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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