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https://www.readbyqxmd.com/read/28441733/bioactivity-studies-on-titania-coatings-and-the-estimation-of-their-usefulness-in-the-modification-of-implant-surfaces
#1
Aleksandra Radtke, Adrian Topolski, Tomasz Jędrzejewski, Wiesław Kozak, Beata Sadowska, Marzena Więckowska-Szakiel, Piotr Piszczek
Morphologically different titania coatings (nanofibers (TNFs), nanoneedles (TNNs), and nanowires (TNWs)) were studied as potential biomedical materials. The abovementioned systems were produced in situ on Ti6Al4V substrates via direct oxidation processes using H₂O₂ and H₂O₂/CaCl₂ agents, and via thermal oxidation in the presence of Ar and Ar/H₂O₂. X-ray diffraction and Raman spectroscopy have been used to structurally characterize the produced materials. The morphology changes on the titanium alloy surface were investigated using scanning electron microscopy...
April 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28436646/filaments-with-affinity-binding-and-wet-strength-can-be-achieved-by-spinning-bifunctional-cellulose-nanofibrils
#2
Maija Vuoriluoto, Hannes Orelma, Meri Johanna Lundahl, Maryam Borghei, Orlando J Rojas
We demonstrate benzophenone (BP) conjugation via amine-reactive esters onto oxidized cellulosic fibers that were used as precursors, after microfluidization, of photo-active cellulose nanofibrils (CNF). From these fibrils, cellulose I filaments were synthesized by hydrogel spinning in an anti-solvent followed by fast bi-radical UV crosslinking. As a result, the BP-CNF filaments developed a wet tensile strength of up to ~105 MPa (a remarkable retention of ~80% of the dry strength). Thus, the principal limitation of these emerging materials was resolved (< 0...
April 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28435943/influence-of-charged-defects-on-the-interfacial-bonding-strength-of-tantalum-and-silver-doped-nanograined-tio2
#3
Jalal Azadmanjiri, James Wang, Christopher C Berndt, Ajay Kapoor, De Ming Zhu, Andrew S M Ang, Vijay K Srivastava
A nano-grained layer including line defects was formed on the surface of a Ti alloy (Tialloy, Ti-6Al-4V ELI). Then, the micro- and nano-grained Tialloy with the formation of TiO2 on its top surface was coated with a bioactive Ta layer with or without incorporating an antibacterial agent of Ag that was manufactured by magnetron sputtering. Subsequently, the influence of the charged defects (the defects that can be electrically charged on the surface) on the interfacial bonding strength and hardness of the surface system was studied via an electronic model...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28433939/enhanced-proangiogenic-potential-of-mesenchymal-stem-cell-derived-exosomes-stimulated-by-a-nitric-oxide-releasing-polymer
#4
Wei Du, Kaiyue Zhang, Shuaiqiang Zhang, Ran Wang, Yan Nie, Hongyan Tao, Zhibo Han, Lu Liang, Di Wang, Jianfeng Liu, Na Liu, Zhongchao Han, Deling Kong, Qiang Zhao, Zongjin Li
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of degenerative diseases or injury and may provide an alternative to cell-based therapy. However, the compositions in MSC-derived exosomes are highly influenced by the microenvironment in which their original cells reside. Here, we hypothesized that a nitric oxide (NO)-releasing polymer can boost the proangiogenic compositions of exosomes and enhance their proangiogenic capacity. Our results demonstrated that exosomes, released from human placenta-derived MSCs (hP-MSCs) by NO stimulation, augment the angiogenic effects of human umbilical vein endothelial cells (HUVECs) in vitro...
April 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28430345/healing-response-of-rat-pulp-treated-with-an-injectable-keratin-hydrogel
#5
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
April 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28423078/characterization-and-bioactivities-of-a-novel-polysaccharide-obtained-from-gracilariopsis-lemaneiformis
#6
Chen-Shan Shi, Ya-Xin Sang, Gui-Qing Sun, Tian-Ye Li, Zheng-Si Gong, Xiang-Hong Wang
Gracilariopsis lemaneiformis is a type of red alga that contains seaweed polysaccharide agar. In this study, a novel non-agar seaweed polysaccharide fraction named GCP (short of crude polysaccharide obtained from Gracilariopsis lemaneiformis) was isolated from Gracilariopsis lemaneiformis. Structural analysis showed that GCP shows triple helical chain conformation when dissolved in water and has many branches and long side chains. Also, 1→3 linkage is the major linkage and the sugar structures are galactopyranose configurations linked by β-type glycosidic linkages...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28421736/enhancing-the-bioactivity-of-yttria-stabilized-tetragonal-zirconia-ceramics-via-grain-boundary-activation
#7
Jinhuan Ke, Jiandong Ye, Fupo He
Yttria-stabilized tetragonal zirconia (Y-TZP) has been proposed as a potential dental implant due to its good biocompatibility, excellent mechanical properties, and distinctive aesthetic effect. However, Y-TZP cannot form chemical bonds with bone tissue because of its biological inertness, which affects the reliability and long-term efficacy of Y-TZP implants. In this study, to improve the bioactivity of Y-TZP ceramics while maintaining their good mechanical performance, Y-TZP was modified by grain boundary activation via the infiltration of a bioactive glass (BG) sol into the surface layer of Y-TZP ceramics under different negative pressures (atmospheric pressure, -0...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28419924/centrifugal-partition-chromatography-in-the-isolation-of-minor-ecdysteroids-from-cyanotis-arachnoidea
#8
Halima Meriem Issaadi, Yu-Chi Tsai, Fang-Rong Chang, Attila Hunyadi
Phytoecdysteroids are known for their various beneficial bioactivities in mammals including a non-hormonal anabolic and adaptogenic effect. Cyanotis arachnoidea extracts are extensively utilized worldwide as ecdysteroid-rich materials for various purposes, e.g. food supplementation, use in agriculture and aquaculture, etc. Preparative chromatography of ecdysteroids requires extensive use of methods of different selectivity, and only a very limited number of papers are available on related application of modern liquid-liquid chromatographic techniques...
April 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28416873/collagen-extraction-from-mussel-byssus-a-new-marine-collagen-source-with-physicochemical-properties-of-industrial-interest
#9
F Rodríguez, L Morán, G González, E Troncoso, R N Zúñiga
Mussel byssus is a by-product of mussel production and is a potential source of collagen. The goal of this study was to extract collagen from the byssus of Chilean mussel using an enzymatic method and characterize it. A pepsin-aided extraction method was employed where first an enzymatic hydrolysis at two pepsin/substrate ratios (1:50 or 4:50) and times (4 or 24 h) was done. Extraction was conducted at 80 °C for 24 h, in a 0.5 N acetic acid solution. All samples were analyzed for collagen content, amino acid profile, turbidity, viscosity, solubility, denaturation temperature and surface tension...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28416208/fetal-and-perinatal-stem-cells-in-cardiac-regeneration-moving-forward-to-the-paracrine-era
#10
C Balbi, S Bollini
Cardiovascular disease (CD) is a major burden for Western society. Regenerative medicine has provided encouraging results, yet it has not addressed the focal defects causing CD and mainly related to the inefficient repair programme of the heart. In this scenario, stem cells have been broadly investigated and their paracrine effect proposed as a possible working strategy to boost endogenous mechanisms of repair and regeneration from within the cardiac tissue. The scientific community is now focusing on identifying the most effective stem cell secretome, as the whole of bioactive factors and extracellular vesicles secreted by stem cells and endowed with regenerative potential...
April 12, 2017: Placenta
https://www.readbyqxmd.com/read/28415541/synthesis-characterization-of-caf2-doped-silicate-glass-ceramics
#11
Madeeha Riaz, Rehana Zia, Ambreen Mirza, Tousif Hussain, Farooq Bashir, Safia Anjum
This paper reports the fabrication and characterization of silicate glass-ceramics doped with (0-12mol%) CaF2. TGA-DSC analysis was carried out to determine the crystallization temperature and stability of glass measured by two glass parameters; Hruby parameter KH=(Tx-Tg)/(TL-Tx) and Weinberg parameter KW=(Tc-Tg)/TL. It was found that with CaF2 doping improved sinterability at low temperature and provided stability to the glass. The XRD pattern exhibits a single phase of combeite and doping of CaF2 cause increase in crystallite size...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415511/facile-synthesis-and-characterization-of-novel-rapid-setting-spherical-sub-micron-bioactive-glasses-cements-and-their-biocompatibility-in-vitro
#12
Yuli Li, Qiming Liang, Cai Lin, Xian Li, Xiaofeng Chen, Qing Hu
Dental pulp vitality is extremely important for the tooth viability, since it provides nutrition and forms the dentin. Bioactive glasses (BGs) may be promising materials for pulp repair due to their excellent abilities of rapidly bonding to bone and stimulating new bone growth. However, the unsatisfied handling property, low plasticity, and poor rapid-setting property of traditional BGs limit its application in vital pulp therapy. Spherical bioactive glasses (SBGs) exhibited higher osteogenesis and odontogenic differentiation than irregular BGs...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415503/synthesis-of-nanosized-58s-bioactive-glass-particles-by-a-three-dimensional-ordered-macroporous-carbon-template
#13
Lijun Ji, Wei Qiao, Kai Huang, Yuheng Zhang, Huayu Wu, Shiyong Miao, Hongfei Liu, Yixiang Dong, Aiping Zhu, Dong Qiu
Nanosized 58S bioactive glass (BG) particles were synthesized by using a three-dimensional ordered macroporous carbon template (OMC) with a pore size of 400nm. The obtained 58S BG particles possessed a diameter of 300nm, narrow size distribution and uniform spherical morphology. 58S/gelatin composites were prepared and showed much better mechanical properties than pure gelatin. The narrow size distribution of the 58S particles replicated from OMC was confirmed crucial to the mechanical properties of the 58S/gelatin composite, comparing to the contrast sample prepared with polydispersed particles...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415475/novel-non-cytotoxic-bioactive-and-biodegradable-hybrid-materials-based-on-polyurethanes-tio2-for-biomedical-applications
#14
Dulce M González-García, L Téllez Jurado, R Jiménez-Gallegos, Luis M Rodríguez-Lorenzo
Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO2 for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO2 (80% organic-20% inorganic) and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415472/supercritical-carbon-dioxide-extracted-extracellular-matrix-material-from-adipose-tissue
#15
Jun Kit Wang, Baiwen Luo, Vipra Guneta, Liang Li, Selin Ee Min Foo, Yun Dai, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choong, Marcus Thien Chong Wong
Adipose tissue is a rich source of extracellular matrix (ECM) material that can be isolated by delipidating and decellularizing the tissue. However, the current delipidation and decellularization methods either involve tedious and lengthy processes or require toxic chemicals, which may result in the elimination of vital proteins and growth factors found in the ECM. Hence, an alternative delipidation and decellularization method for adipose tissue was developed using supercritical carbon dioxide (SC-CO2) that eliminates the need of any harsh chemicals and also reduces the amount of processing time required...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415445/microstructural-and-surface-modifications-and-hydroxyapatite-coating-of-ti-6al-4v-triply-periodic-minimal-surface-lattices-fabricated-by-selective-laser-melting
#16
Chunze Yan, Liang Hao, Ahmed Hussein, Qingsong Wei, Yusheng Shi
Ti-6Al-4V Gyroid triply periodic minimal surface (TPMS) lattices were manufactured by selective laser melting (SLM). The as-built Ti-6Al-4V lattices exhibit an out-of-equilibrium microstructure with very fine α' martensitic laths. When subjected to the heat treatment of 1050°C for 4h followed by furnace cooling, the lattices show a homogenous and equilibrium lamellar α+β microstructure with less dislocation and crystallographic defects compared with the as-built α' martensite. The as-built lattices present very rough strut surfaces bonded with plenty of partially melted metal particles...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415442/small-intestinal-submucosa-a-potential-osteoconductive-and-osteoinductive-biomaterial-for-bone-tissue-engineering
#17
Mei Li, Chi Zhang, Mengjie Cheng, Qiaoqiao Gu, Jiyuan Zhao
SIS is an acellular, naturally occurring collagenous extracellular matrix (ECM) material with various bioactive factors, which broadly applied in tissue engineering in clinic. Several studies have applied SIS in bone tissue engineering to enhance bone regeneration in animal models. However, the mechanism was rarely investigated. The aim of the current study was to investigate the osteoconductivity and osteoinductivity of SIS scaffold to bone regeneration systematically and the potential mechanism. Our results showed that SIS scaffold with excellent biocompatibility was beneficial for cell attachment, proliferation, migration and osteogenic differentiation of various cells contributing to bone repair...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412552/copper-containing-mesoporous-bioactive-glass-nanoparticles-as-multifunctional-agent-for-bone-regeneration
#18
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giogia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M González-Calbet, Livia Visai, Chiara Vitale-Brovarone
The application of mesoporous bioactive glasses (MBGs) containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure...
April 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28412451/laser-treated-electrospun-fibers-loaded-with-nano-hydroxyapatite-for-bone-tissue-engineering
#19
Javier Aragon, Nuria Navascues, Gracia Mendoza, Silvia Irusta
Core-shell polycaprolactone/polycaprolactone (PCL/PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) electrospun fibers loaded with synthesized nanohydroxyapatite (HAn) were lased treated to create microporosity. The prepared materials were characterized by XRD, FTIR, TEM and SEM. Uniform and randomly oriented beadless fibrous structures were obtained in all cases. Fibers diameters were in the 150-300nm range. Needle-like HAn nanoparticles with mean diameters of 20nm and length of approximately 150nm were mostly encase inside the fibers...
April 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28411365/analysis-of-glycosylated-flavonoids-extracted-from-sweet-cherry-stems-as-antibacterial-agents-against-pathogenic-escherichia-coli-isolates
#20
Alfredo Aires, Carla Dias, Rosa Carvalho, Maria José Saavedra
The aim of this study was to evaluate the bioactivity of flavonoids extracted from sweet-cherry stems which are often used by a traditional system of medicine to treat gastro-intestinal and urinary tract infections but lacking any consistent scientific evidence; moreover the information about the class of phenolics, their content and the potential bioactivity of such material is very scarce. Thus, in this context, we have set a research study in which we evaluated the profile and content of phenolics extracted from sweet-cherry stems through a conventional (70ºC and 20 min) and ultrasound assisted extraction (40 kHz, room temperature and 20 min)...
April 14, 2017: Acta Biochimica Polonica
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