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https://www.readbyqxmd.com/read/28088667/cell-laden-hydrogels-for-osteochondral-and-cartilage-tissue-engineering
#1
REVIEW
Jingzhou Yang, Yu Shrike Zhang, Kan Yue, Ali Khademhosseini
: Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088624/oxidative-phospholipidomics-in-health-and-disease-achievements-challenges-and-hopes
#2
REVIEW
Ana Reis
Phospholipid peroxidation products are recognized as important bioactive lipid mediators playing an active role as modulators in signalling events in inflammation, immunity and infection. The biochemical responses are determined by the oxidation structural features present in oxPL modulating biophysical and biological properties in model membranes and lipoproteins. In spite of the extensive work conducted with model systems over the last 20 years, the study of oxPL in biological systems has virtually stagnated...
January 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28076889/polyurethane-conjugating-tgf-%C3%AE-on-surface-impacts-local-inflammation-and-endoplasmic-reticulum-stress-in-skeletal-muscle
#3
Dandan Shi, Jiangwei Xiao, Ruicai Gu, Gang Wu, Hua Liao
The synthesized short peptide-polymers would provide key functions for tissue regeneration and repair, through enriching bioactive molecules on polymers or releasing these molecules pre-conjugated on the materials. We have developed a degradable PU bearing HSNGLPL peptide, which has affinity binding ability to TGF-β. For deeply understanding spatial release of TGF-β from the PU polymers and its localized bioactivity, QCM and Elisa test were used to verify TGF-β binding capacities in vitro and in vivo. The PU polymers, with or without pre-conjugating of TGF-β, were implanted into gastronomies muscle (GN) of C57BL/6 mice, for addressing TGF-β release from the polymers and its bio-regulating function in vivo...
January 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28076651/controlled-release-of-chlorhexidine-from-a-mesoporous-silica-containing-macroporous-titanium-dental-implant-prevents-microbial-biofilm-formation
#4
K De Cremer, A Braem, E Gerits, K De Brucker, K Vandamme, J A Martens, J Michiels, J Vleugels, B P Cammue, K Thevissen
Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titanium-silica (Ti/SiO2) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds...
January 11, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28075573/functional-graphene-nanomaterials-based-architectures-biointeractions-fabrications-and-emerging-biological-applications
#5
Chong Cheng, Shuang Li, Arne Thomas, Nicholas A Kotov, Rainer Haag
Functional graphene nanomaterials (FGNs) are fast emerging materials with extremely unique physical and chemical properties and physiological ability to interfere and/or interact with bioorganisms; as a result, FGNs present manifold possibilities for diverse biological applications. Beyond their use in drug/gene delivery, phototherapy, and bioimaging, recent studies have revealed that FGNs can significantly promote interfacial biointeractions, in particular, with proteins, mammalian cells/stem cells, and microbials...
January 11, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28073678/natural-potential-neuroinflammatory-inhibitors-from-alhagi-sparsifolia-shap
#6
Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li
Neuroinflammation is a key contributor to neuronal damage in neurodegenerative diseases. In our previous work on natural effective neuroinflammatory inhibitors, Alhagi sparsifolia Shap. (Leguminosae), a folk medicine widely distributed in Xinjiang, attracted our attention because of its significant anti-neuroinflammatory effect. Therefore, further investigation of the bioactive material basis was carried out. As a result, 33 major components were characterized and identified by chromatographic and spectral methods, respectively...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28073559/characterization-of-total-retinoid-like-activity-of-compounds-produced-by-three-common-phytoplankton-species
#7
Eliška Sychrová, Jana Priebojová, Marie Smutná, Kateřina Nováková, Jiří Kohoutek, Klára Hilscherová
Phytoplankton can produce various bioactive metabolites, which may affect other organisms in the aquatic environment. This study provides the first information on the total retinoid-like activity associated with both intracellular and extracellular metabolites produced by selected phytoplankton species that could play a role in teratogenic effects and developmental disruption in exposed organisms. The studied species included a coccoid cyanobacteria (Microcystis aeruginosa), a filamentous cyanobacteria (Aphanizomenon gracile) and a green alga (Desmodesmus quadricauda), all of which commonly occur in freshwater bodies in Europe...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28071031/study-of-variation-of-tocochromanol-and-phytosterol-contents-in-black-and-yellow-seeds-of-brassica-napus-l-doubled-haploid-populations
#8
Teresa Cegielska-Taras, Małgorzata Nogala-Kałucka, Laurencja Szala, Aleksander Siger
BACKGROUND: In the study, an analysis of tocopherols, plastochomanol-8 and phytosterols was conducted using DH lines obtained from F1 hybrids of reciprocal crosses between yellow- and black-seeded lines. METHODS: The biological material for the study consisted of two DH populations of winter oilseed rape obtained from F1 hybrids of reciprocal crosses between two DH lines: yellow- and black-seeded. Seed color was determined using a ColorFlex spectrophotometer. Fat content was determined via pulsed NMR...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28069505/end-point-immobilization-of-heparin-on-plasma-treated-surface-of-electrospun-polycarbonate-urethane-vascular-graft
#9
Xuefeng Qiu, Benjamin Li-Ping Lee, Xinghai Ning, Niren Murthy, Nianguo Dong, Song Li
: Small-diameter synthetic vascular grafts have high failure rate due to primarily surface thrombogenicity, and effective surface chemical modification is critical to maintain the patency of the grafts. In this study, we engineered a small-diameter, elastic synthetic vascular graft with off-the-shelf availability and anti-thrombogenic activity. Polycarbonate-urethane (PCU), was electrospun to produce nanofibrous grafts that closely mimicked a native blood vessel in terms of structural and mechanical strength...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28067513/evolution-of-quantitative-measures-in-nmr-quantum-mechanical-qhnmr-advances-chemical-standardization-of-a-red-clover-trifolium-pratense-extract
#10
Rasika S Phansalkar, Charlotte Simmler, Jonathan Bisson, Shao-Nong Chen, David C Lankin, James B McAlpine, Matthias Niemitz, Guido F Pauli
Chemical standardization, along with morphological and DNA analysis ensures the authenticity and advances the integrity evaluation of botanical preparations. Achievement of a more comprehensive, metabolomic standardization requires simultaneous quantitation of multiple marker compounds. Employing quantitative (1)H NMR (qHNMR), this study determined the total isoflavone content (TIfCo; 34.5-36.5% w/w) via multimarker standardization and assessed the stability of a 10-year-old isoflavone-enriched red clover extract (RCE)...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28061402/sequentially-crosslinked-bioactive-hydrogels-as-nano-patterned-substrates-with-customizable-stiffness-and-degradation-for-corneal-tissue-engineering-applications
#11
Muhammad Rizwan, Gary S L Peh, Heng-Pei Ang, Nyein Chan Lwin, Khadijah Adnan, Jodhbir S Mehta, Wui Siew Tan, Evelyn K F Yim
Naturally-bioactive hydrogels like gelatin provide favorable properties for tissue-engineering but lack sufficient mechanical strength for use as implantable tissue engineering substrates. Complex fabrication or multi-component additives can improve material strength, but often compromises other properties. Studies have shown gelatin methacrylate (GelMA) as a bioactive hydrogel with diverse tissue growth applications. We hypothesize that, with suitable material modifications, GelMA could be employed for growth and implantation of tissue-engineered human corneal endothelial cell (HCEC) monolayer...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28058105/c-h-functionalization-of-amines-with-aryl-halides-by-nickel-photoredox-catalysis
#12
Derek T Ahneman, Abigail G Doyle
We describe the functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive molecules. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst. This reactivity is demonstrated for a range of aryl halides and N-aryl amines, with orthogonal scope to existing C-H activation and photoredox methodologies...
December 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#13
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28049020/eradication-ofpseudomonas-aeruginosacells-by-cathodic-electrochemical-currents-delivered-with-graphite-electrodes
#14
Tagbo H R Niepa, Hao Wang, Jeremy L Gilbert, Dacheng Ren
Antibiotic resistance is a major challenge to the treatment of bacterial infections associated with medical devices and biomaterials. One important intrinsic mechanism of such resistance is the formation of persister cells that are phenotypic variants of microorganisms and highly tolerant to antibiotics. Recently, we reported a new approach to eradicating persister cells of Pseudomonas aeruginosa using low-level direct electrochemical current (DC) and synergy with the antibiotic tobramycin. To further understand the underlying mechanism and develop this technology toward possible medical applications, we investigated the electricidal activities of non-metallic biomaterial on persister and biofilm cells of P...
December 31, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28048962/chemical-ecology-of-wave-swept-shores-the-primacy-of-contact-cues-in-predation-by-whelks
#15
Graham A Ferrier, Cheryl Ann Zimmer, Richard K Zimmer
Wave-swept shores are valuable for developing and testing key ecological principles. A synthesis of research is nonetheless missing a critical component: the chemosensory basis for behavioral interactions that determine population- and community-wide attributes. Chemical signaling environments on wave-swept shores, given their intense, turbulent mixing and complex topographies, would be difficult or impossible to simulate in a laboratory setting. For this reason, appropriately scaled field studies are needed to advance understanding of chemical stimuli and their biotic effects...
December 2016: Biological Bulletin
https://www.readbyqxmd.com/read/28035976/meadowsweet-teas-as-new-functional-beverages-comparative-analysis-of-nutrients-phytochemicals-and-biological-effects-of-four-filipendula-species
#16
Daniil N Olennikov, Nina I Kashchenko, Nadezhda K Chirikova
In recent years, the increased popularity of functional beverages such as herbal teas and decoctions has led to the search for new sources of raw materials that provide appropriate taste and functionality to consumers. The objective of this study was to investigate the nutritional, phytochemical profiles and bioactivities of possible functional beverages produced from F. ulmaria and its alternative substitutes (F. camtschatica, F. denudata, F. stepposa). The investigated decoctions were analyzed regarding their macronutrient, carbohydrate, organic acid, amino acid and mineral composition...
December 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28035192/a-chemical-biological-similarity-based-grouping-of-complex-substances-as-a-prototype-approach-for-evaluating-chemical-alternatives
#17
Fabian A Grimm, Yasuhiro Iwata, Oksana Sirenko, Grace A Chappell, Fred A Wright, David M Reif, John Braisted, David L Gerhold, Joanne M Yeakley, Peter Shepard, Bruce Seligmann, Tim Roy, Peter J Boogaard, Hans B Ketelslegers, Arlean M Rohde, Ivan Rusyn
Comparative assessment of potential human health impacts is a critical step in evaluating both chemical alternatives and existing products on the market. Most alternatives assessments are conducted on a chemical-by-chemical basis and it is seldom acknowledged that humans are exposed to complex products, not individual substances. Indeed, substances of Unknown or Variable composition, Complex reaction products, and Biological materials (UVCBs) are ubiquitous in commerce yet they present a major challenge for registration and health assessments...
August 21, 2016: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://www.readbyqxmd.com/read/28033183/investigation-of-osteoinductive-effects-of-different-compositions-of-bioactive-glass-nanoparticles-for-bone-tissue-engineering
#18
AmirHossein Tavakolizadeh, Mehdi Ahmadian, MohammadHossein Fathi, Ali Doostmohammadi, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi
Bioactive glasses (BG) is one of the well-known materials that used as dental and bone implants, for this reason it is always interesting for researchers has been to increase BG efficiency in the bone tissue engineering. The aim of this work was to evaluate the osteoinductivity of BG different composition nanoparticles with SiO2-CaO-P2O5. The 45S, 58S, and 63S compositions were prepared via the sol-gel technique. Characterization techniques such as X-ray diffraction, field emission scanning electron microscopy (FE-SEM), and laser Doppler electrophoresis (LDE) were used...
December 26, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28033065/effects-of-bioactive-compounds-on-odontogenic-differentiation-and-mineralization
#19
S Phung, C Lee, C Hong, M Song, J K Yi, R G Stevenson, M K Kang, K-H Shin, N-H Park, R H Kim
Direct pulp capping involves the placement of dental materials directly onto vital pulp tissues after deep caries removal to stimulate the regeneration of reparative dentin. This physical barrier will serve as a "biological seal" between these materials and the pulp tissue. Although numerous direct pulp capping materials are available, the use of small bioactive compounds that can potently stimulate and expedite reparative dentin formation is still underexplored. Here, the authors compared and evaluated the pro-osteogenic and pro-odontogenic effects of 4 small bioactive compounds- phenamil (Phen), purmorphamine (Pur), genistein (Gen), and metformin (Met)...
January 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28029249/structure-and-function-of-aapeptides
#20
Olapeju Bolarinwa, Alekhya Nimmagadda, Ma Su, Jianfeng Cai
The intrinsic drawbacks encountered in bioactive peptides in chemical biology and biomedical sciences have diverted research efforts to the development of sequence-specific peptidomimetics which are capable of mimicking the structure and function of peptides and proteins. Modifications in the backbone and/or the side chain of peptides have been explored to develop biomimetic molecular probes or drug leads for biologically important targets. To expand the family of oligomeric peptidomimetics so as to facilitate their further application, we recently developed a new class of peptidomimetics - AApeptides based on chiral peptide nucleic acid (PNA) backbone...
December 28, 2016: Biochemistry
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