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bioactive material

Fujian Zhao, Bo Lei, Xian Li, Yunfei Mo, Renxian Wang, Dafu Chen, Xiaofeng Chen
Early vascularization capacity of biomaterials plays an essential role in efficient wound healing and tissue regeneration, especially in large tissue tension implanting position such as bone augmentation. Strontium-contained silica-based bioactive materials have shown the role of promoting angiogenesis by stimulating osteoblasts to secrete angiogenesis related cytokines. However, osteoblasts have little effect on early angiogenesis due to the inflammatory reaction of implantation site. Here, for the first time, we found that the monodispersed strontium-contained bioactive glasses microspheres (SrBGM) could significantly promote the early angiogenesis through regulating macrophage phenotypes...
June 8, 2018: Biomaterials
Songee Beak, Hyeri Kim, Kyung Bin Song
Sea squirt (Halocynthia roretzi) shell protein (SSP) was used as a biodegradable film material and laminated with polylactic acid (PLA) to improve its physical and water barrier properties. Cinnamon bark oil (CBO) was incorporated into the SSP film as a bioactive material. After laminating with PLA, the tensile strength and elongation at break of the SSP film increased from 4.07 to 9.09 MPa and from 8.68 to 138.84%, respectively. In addition, water vapor permeability and water solubility decreased from 5.62 to 0...
June 15, 2018: Journal of Food Science
David Josh Cohen, Sharon L Hyzy, Salma Haque, Lucas C Olson, Barbara Boyan, Justin M Saul, Zvi Schwartz
Keratin proteins derived from human hair are known to contain a large number of cysteine residues. In hydrogels composed of oxidatively extracted keratin (keratose), sulfonic acid on the cysteine residues prevents disulfide crosslinking. Reductively extracted keratin (kerateine) has thiol groups on cysteine residues that can form disulfide crosslinks. The rates of keratin hydrogel erosion and, in some cases, drug release can be tuned by manipulating disulfide crosslinking levels via the keratose:kerateine (KOS:KTN) ratio...
June 15, 2018: Tissue Engineering. Part A
Dawlat Mostafa, Moustafa Aboushelib
BACKGROUND: Zirconia is characterized by a hard, dense, and chemically inert surface which requires additional surface treatments in order to enhance osseointegration. The proposed hypothesis of the study was that combination of a nano-porous surface infiltrated with a bioactive material may enhance osseointegration of zirconia implants. METHODS: Custom-made zirconia implants (3.7 mm × 8 mm) were designed, milled, and sintered according to manufacturer recommendations...
June 14, 2018: International Journal of Implant Dentistry
Gabriel Fernandez de Grado, Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Anne-Marie Musset, Nadia Benkirane-Jessel, Fabien Bornert, Damien Offner
Bone replacement might have been practiced for centuries with various materials of natural origin, but had rarely met success until the late 19th century. Nowadays, many different bone substitutes can be used. They can be either derived from biological products such as demineralized bone matrix, platelet-rich plasma, hydroxyapatite, adjunction of growth factors (like bone morphogenetic protein) or synthetic such as calcium sulfate, tri-calcium phosphate ceramics, bioactive glasses, or polymer-based substitutes...
January 2018: Journal of Tissue Engineering
Patrick Kaiser, Steffen Reich, Andreas Greiner, Ruth Freitag
Biocomposites, i.e., materials consisting of metabolically active microorganisms embedded in a synthetic extracellular matrix, may find applications as highly specific catalysts in bioproduction and bioremediation. 3D constructs based on fibrous biocomposites, so-called "artificial biofilms," are of particular interest in this context. The inability to produce biocomposite fibers of sufficient mechanical strength for processing into bioactive fabrics has so far hindered progress in the area. Herein a method is proposed for the direct wet spinning of microfibers suitable for weaving and knitting...
June 12, 2018: Macromolecular Bioscience
Seyedali Seyedmajidi, Maryam Seyedmajidi, Ebrahim Zabihi, Karimollah Hajian-Tilaki
Considering to the possibility of cellular and genetic damage by the implant materials in the patient and the clinician, the safety of the biomaterials should be evaluated. The purpose of this study was to compare the cytotoxicity and genotoxicity induced by two nanocomposites, hydroxyapatite/bioactive glass (HA/BG) and fluorapatite/bioactive glass (FA/BG) in vitro. Biomaterial extracts (BMEX, 100%) were prepared by incubating 100 mg/mL of each biomaterial powder in complete culture medium (RPMI1640 + 10% FBS) for 72 hours...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Qingpan Zhai, Fengxuan Han, Zhiwei He, Chen Shi, Pinghui Zhou, Caihong Zhu, Qianping Guo, Xuesong Zhu, Huilin Yang, Bin Li
Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and stress shielding. In this study, we aimed to develop a new type of partially biodegradable composite bone cement by incorporating magnesium (Mg) microspheres, known as "Mg sacrifices" (MgSs), in the PMMA matrix...
June 12, 2018: International Journal of Molecular Sciences
Jelena Panak Balentić, Đurđica Ačkar, Stela Jokić, Antun Jozinović, Jurislav Babić, Borislav Miličević, Drago Šubarić, Nika Pavlović
Solving the problem of large quantities of organic waste, which represents an enormous ecological and financial burden for all aspects of the process industry, is a necessity. Therefore, there is an emerged need to find specific solutions to utilize raw materials as efficiently as possible in the production process. The cocoa shell is a valuable by-product obtained from the chocolate industry. It is rich in protein, dietary fiber, and ash, as well as in some other valuable bioactive compounds, such as methylxanthines and phenolics...
June 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhiyan Tian, Ning Ren, Jinghua Wang, Danhong Zhang, Yuying Zhou
BACKGROUND Ginsenoside is the major bioactive component of ginseng, which has been proven to be a neuroprotective drug. The aim of this study was to evaluate the therapeutic effect of ginsenoside in a diabetic Goto-Kakizaki (GK) rat model. MATERIAL AND METHODS Twenty GK rats were randomly divided into a diabetic model (DM) group (n=10) and a ginsenoside + DM group (n=10); Wistar rats with the same age and body weight were used as the control (CON) group (n=10). Food and water intake, body weight, and blood fasting plasma glucose were measured...
June 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Tao Chen, Si Wang, Fan He, Zhijun Guo, Pei Hu, Rui Zhao, Yuanding Huang, Qianming Chen, Ping Ji, Liangyin Chu, Shujuan Zou
A bioactive paradigm is required to promote osseointegration of implant materials. Here, a protamine/alginate/bone morphogenic protein 2 (BMP2) biofunctionalized composite coating was created on nanopolymorphic titanium (Ti) surfaces to promote the osseointegration of Ti implants. Alkali and heat (AH) treatment was used to make porous Ti implants (TiAH) with a superhydrophilic and negatively charged surface, which facilitates the adsorption of a positively charged protamine/alginate/protamine (TiAH-Pro/Alg/Pro) coating...
May 1, 2018: Journal of Biomedical Nanotechnology
Bo-Jiang Hong, Chih-Wei Hsiao, Fufa Fetene Bakare, Jung-Ting Sun, Shao-Ju Shih
Mesoporous bioactive glass (MBG) is considered as one of the most important materials in the field of bone implants and drug carriers, owing to its superior bioactivity. In previous studies, tri-block surfactants (e.g., F127 and P123) were commonly used as pore-forming agents. However, the use of surfactants may cause serious problems such as micelle aggregation and carbon contamination and thus decrease bioactivity. Therefore, in this study, we demonstrated the synthesis of MBG using acetic acid (HAc) as a pore-forming agent to overcome the disadvantages caused by surfactants...
June 6, 2018: Materials
Marta Miola, Andrea Cochis, Ajay Kumar, Carla Renata Arciola, Lia Rimondini, Enrica Verné
To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass was incorporated into commercial polymethyl methacrylate (PMMA)-based cements with different viscosities. The realized composites were characterized in terms of morphology, composition, leaching ability, bioactivity, mechanical, and antibacterial properties...
June 6, 2018: Materials
Jenni Tienaho, Emmi Poikulainen, Tytti Sarjala, Riina Muilu-Mäkelä, Ville Santala, Matti Karp
Ultraviolet radiation (UV-R) causes genotoxic and aging effects on skin, and sunscreens are used to alleviate the damage. However, sunscreens contain synthetic shielding agents that can cause harmful effects in the environment. Nature-derived substances may have potential as replacement materials for the harmful sunscreen chemicals. However, screening of a broad range of samples is tedious, and often requires a separate genotoxicity assessment. We describe a simple microplate technique for the screening of UV protective substances using a recombinant Escherichia coli biosensor...
June 8, 2018: Photochemistry and Photobiology
Dongmei Li, Lili Zhou, Qingwei Wang, Yang He
Coptis herbs are important herbal medicinal materials. The bioactive composition, the quality and medicinal efficacy of these herbs, are determined significantly by their geo-authentic features. Among the effective components of these herbs are seven organic acids (quinic, acetic, formic, tartaric, malic, succinic, and oxalic acids). However, no quantitative data of these seven acids in these herbs are available. Therefore, we developed a method for simultaneous separation and determination of the seven organic acids in Coptis herbs using gradient ion chromatography (mobile phase and gradient were shown in Table 1)...
June 2018: 3 Biotech
George Kerry Rout, Han-Seung Shin, Sushanto Gouda, Sabuj Sahoo, Gitishree Das, Leonardo Fernandes Fraceto, Jayanta Kumar Patra
Nanodrug delivery systems sometimes referred to as nanocarriers (NCs) are nanoengineered biocompatible materials or devices, which in conjugation with desired bioactive compounds plays an indispensable functional role in the field of pharmaceutical and allied sciences. The diversified ability of this bioengineered colloidal or noncolloidal molecule to breach the biological barriers to reach the targeted location in the biological system uplifts its other versatile natures of mono- or polydispersity in biodistribution...
June 7, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Alice Rosenthal, Amy Mantz, Albert L Nguyen, Eva Bittrich, Eva Schubert, Mathias M Schubert, Manfred Stamm, Angela K Pannier, Petra Uhlmann
The grafting of polymer brushes to substrates is a promising method to modify surface properties such as wettability and the affinity toward proteins and cells for applications in microelectronics, biomedical devices and sensors. Poly(acrylic) acid (PAA) brushes are of high interest because of their stimuli-responsive behavior and the presence of carboxy (COOH) groups which allow for immobilization of bioactive molecules. The "grafting to" approach results in homogeneous and well-defined polymer brushes but, while "grafting to" has been demonstrated with PAA brushes on silicon (Si) substrates, it has not been performed on biocompatible materials like titanium (Ti)...
June 7, 2018: Journal of Physical Chemistry. B
Zeljka Rupcic, Stephan Hüttel, Steffen Bernecker, Sae Kanaki, Marc Stadler
A method was established for the production of 1.2-fold and 4.2-fold increased amounts of the antiviral and central nervous system-active lantipeptides, labyrinthopeptins A1 and A2, respectively, isolated from the actinobacterium Actinomadura namibiensis , to enable production in gram scale. We then performed in vivo characterization of this promising compound class. The labyrinthopeptins A1 and A2 have similar chemical structures and physical properties but differ drastically in their bioactivities. Therefore, large quantities of highly pure material are required for pharmacological studies...
June 5, 2018: Bioengineering
Xianfeng Zhou, Zhibo Li
Polypeptide hydrogels, having the ability to mimic certain properties of natural, native extracellular matrix components, are being actively designed and described for various applications in the construction of tissue engineering scaffolds, living cell encapsulation, and drug delivery systems. Compared to conventional hydrogels, polypeptide hydrogels possess biocompatibility, biodegradability, bioactivity, functional diversity, and structural advantage based on the unique secondary structures (α-helix and β-sheet)...
June 5, 2018: Advanced Healthcare Materials
Sara Ferraris, Martina Cazzola, Veronica Peretti, Barbara Stella, Silvia Spriano
Surface properties of biomaterials (e.g., roughness, chemical composition, charge, wettability, and hydroxylation degree) are key features to understand and control the complex interface phenomena that happens upon contact with physiological fluids. Numerous physico-chemical techniques can be used in order to investigate in depth these crucial material features. Among them, zeta potential measurements are widely used for the characterization of colloidal suspensions, but actually poorly explored in the study of solid surfaces, even if they can give significant information about surface charge in function of pH and indirectly about surface functional groups and reactivity...
2018: Frontiers in Bioengineering and Biotechnology
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