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https://www.readbyqxmd.com/read/28211933/enhanced-bone-tissue-regeneration-using-a-3d-printed-microstructure-incorporated-with-a-hybrid-nano-hydrogel
#1
Dong Nyoung Heo, Nathan J Castro, Se-Jun Lee, Hanaul Noh, Wei Zhu, Lijie Grace Zhang
Three-dimensional (3D) functional constructs with biomimetic mechanical and chemical properties are ideal for various regenerative medicine applications. These properties of 3D fabricated constructs mainly depend on the intrinsic characteristics of the materials and fabrication method. In this respect, the current use of hydrogels for musculoskeletal tissue repair is not ideal due to the lack of suitable mechanical properties, as well as the high biomimetic requirement for success. To overcome this limitation, we developed a novel functionalized hydrogel with bioactive gold nanoparticles (GNPs), reinforcing a 3D printed microstructure via fused deposition modeling (FDM) for bone tissue regeneration...
February 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28211679/site-directed-immobilization-of-bmp-2-two-approaches-for-the-production-of-innovative-osteoinductive-scaffolds
#2
Barbara Tabisz, Werner Schmitz, Michael Schmitz, Tessa Luehmann, Eva Heusler, Jens-Christoph Rybak, Lorenz Meinel, Juliane E Fiebig, Thomas D Mueller, Joachim Nickel
The regenerative potential of bone is strongly impaired in pathological conditions, such as nonunion fractures. To support bone regeneration various scaffolds have been developed in the past, which have been functionalized with osteogenic growth factors such as bone morphogenetic proteins (BMPs). However, most of them required supra-physiological levels of these proteins leading to burst releases, thereby causing severe side effects. Site-specific, covalent coupling of BMP2 to implant materials might be an optimal strategy in order to overcome these problems...
February 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28211364/antibacterial-effect-of-novel-biodegradable-and-bioresorbable-plda-mg-composites
#3
M C Fernández-Calderón, S C Cifuentes, M A Pacha-Olivenza, A M Gallardo-Moreno, L Saldaña, J L González-Carrasco, M T Blanco, N Vilaboa, M L González-Martín, C Pérez-Giraldo
Polylactic acid/Mg composites have been recently proposed for biodegradable osteosynthesis devices because, with regards to the neat polymer, they combine an enhanced biocompatibility and bioactivity with better mechanical properties, particularly creep strength. A question still arises about their bacterial behavior. For this purpose, composites of poly-L-D-lactic acid (PLDA) loaded with 1 and 10 wt.% of Mg microparticles were evaluated using Staphylococcus epidermidis, with special emphasis on the study of bacterial adhesion and biofilm formation...
February 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28209033/in-vitro-investigation-of-bioactive-glass-ceramic-composites-based-on-biogenic-hydroxyapatite-or-synthetic-calcium-phosphates
#4
Nataliia Pinchuk, Oleksandr Parkhomey, Olena Sych
This in vitro investigation of the behavior of two types of calcium phosphate glass ceramics on the basis of phosphates of biogenic or synthetic origin prepared from initial mixtures with different particle size has revealed that some different factors affect the behavior, namely the phase composition of composite, fraction of open porosity, and average diameter of pore channels. It was established that the solubility of the composites on the basis of synthetic calcium phosphates and glass after 2 and 7 days contact with saline composites is the highest among the materials under study...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28205372/zein-based-composites-in-biomedical-applications
#5
Merve Demir, Laura Ramos-Rivera, Raquel Silva, Showan N Nazhat, Aldo R Boccaccini
Considerable research efforts have been devoted to zein based biomaterials for tissue engineering and other biomedical applications over the past decade. The attention given to zein based polymers is primarily attributed to their biocompatibility and biodegradability. However, due to the relatively low mechanical properties of these polymers, numerous inorganic compounds (e.g, hydroxyapatite, calcium phosphate, bioactive glasses, natural clays) have been considered in combination with zein to create composite materials in an attempt to enhance zein mechanical properties...
February 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28197209/effect-of-bmp-2-delivery-mode-on-osteogenic-differentiation-of-stem-cells
#6
Taekhee Jung, John Hwan Lee, Soonjung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung-Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang
Differentiation of stem cells is an important strategy for regeneration of defective tissue in stem cell therapy. Bone morphogenetic protein-2 (BMP-2) is a well-known osteogenic differentiation factor that stimulates stem cell signaling pathways by activating transmembrane type I and type II receptors. However, BMPs have a very short half-life and may rapidly lose their bioactivity. Thus, a BMP delivery system is required to take advantage of an osteoinductive effect for osteogenic differentiation. Previously, BMP delivery has been designed and evaluated for osteogenic differentiation, focusing on carriers and sustained release system for delivery of BMPs...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28192870/clinical-and-immunohistochemical-performance-of-lyophilized-platelet-rich-fibrin-ly-prf-on-tissue-regeneration
#7
Jianming Zhang, Xingying Qi, Xiaoding Luo, Dan Li, Haorong Wang, Ting Li
BACKGROUND: Platelet-rich fibrin (PRF) has been widely used in oral implantology and other fields, but benefits of the fresh PRF (FPRF (fresh platelet-rich fibrin)) were consequently limited because of its short-term application. Thus, a protocol for the combination of PRF and lyophilization comes up in the present study to address the issue of PRF storage and delayed clinical application, which has little been reported in this field at home and abroad by now. PURPOSE: The aim of the present study was to evaluate the applicability of lyophilized platelet-rich fibrin (Ly-PRF) used as the scaffold material for craniofacial tissue regeneration and to compare its biochemical properties with commonly used fresh PRF...
February 13, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28191928/self-assembling-multidomain-peptide-nanofibers-for-delivery-of-bioactive-molecules-and-tissue-regeneration
#8
Amanda N Moore, Jeffrey D Hartgerink
Multidomain peptides (MDPs) are a class of self-assembling peptides that are organized in a β-sheet motif, resulting in a nanofibrous architecture. This structure is stabilized by hydrophobic packing in the fiber core and a hydrogen-bonding network down the fiber long axis. Under easily controllable conditions, regulated by electrostatic interactions between the peptides and the pH and salt composition of the solvent, the nanofiber length can be dramatically extended, resulting in fiber entanglement and hydrogel formation...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28191616/removal-of-pb-zn-and-cd-from-contaminated-soil-by-new-washing-agent-from-plant-material
#9
Yaru Cao, Shirong Zhang, Guiyin Wang, Qinling Huang, Ting Li, Xiaoxun Xu
Soil washing is an effective approach to remove soil heavy metals, and the washing agent is generally regarded as one of the primary factors in the process, but there is still a lack of efficient and eco-friendly agents for this technique. Here, we showed that four plant washing agents-from water extracts of Coriaria nepalensis (CN), Clematis brevicaudata (CB), Pistacia weinmannifolia (PW), and Ricinus communis (RC)-could be feasible agents for the removal of soil lead (Pb), zinc (Zn), and cadmium (Cd). The metal removal efficiencies of the agents increased with their concentrations from 20 to 80 g L(-1), decreased with the increasing solution pH, and presented different trends with the reaction time increasing...
February 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28191270/a-close-look-at-the-structure-of-the-tio2-aptes-interface-in-hybrid-nanomaterials-and-its-degradation-pathway-an-experimental-and-theoretical-study
#10
Daniela Meroni, Leonardo Lo Presti, Giovanni Di Liberto, Michele Ceotto, Robert G Acres, Kevin C Prince, Roberto Bellani, Guido Soliveri, Silvia Ardizzone
The surface functionalization of TiO2-based materials with alkylsilanes is attractive in several cutting-edge applications, such as photovoltaics, sensors, and nanocarriers for the controlled release of bioactive molecules. (3-Aminopropyl)triethoxysilane (APTES) is able to self-assemble to form monolayers on TiO2 surfaces, but its adsorption geometry and solar-induced photodegradation pathways are not well understood. We here employ advanced experimental (XPS, NEXAFS, AFM, HR-TEM, and FT-IR) and theoretical (plane-wave DFT) tools to investigate the preferential interaction mode of APTES on anatase TiO2...
January 12, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28190466/the-total-triterpenoid-saponins-of-xanthoceras-sorbifolia-improve-learning-and-memory-impairments-through-against-oxidative-stress-and-synaptic-damage
#11
Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Lu-Yi Li, Ji-Kai Xu, Qian Xu, Li-Bo Zou, Da-Li Meng
BACKGROUND: X. sorbifolia is a widely cultivated ecologicalcrop in the north of China which is used to produce biodiesel fuel. It also possesses special medicinal value and has attracted keen interests of researchers to explore its bioactivity. PURPOSE: To extract the total triterpenoid saponins from the husk of X. sorbifolia (TSX) and investigate its effects on Alzheimer's disease (AD). STUDY DESIGN: TSX was prepared via modern extraction techniques...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28190373/effects-of-drying-pretreatment-and-particle-size-adjustment-on-the-composting-process-of-discarded-flue-cured-tobacco-leaves
#12
Gui-Hong Zhao, Yan-Ling Yu, Xiang-Tong Zhou, Bin-Yu Lu, Zi-Mu Li, Yu-Jie Feng
The main characteristic of discarded flue-cured tobacco leaves is their high nicotine content. Aerobic composting is an effective method to decrease the nicotine level in tobacco leaves and stabilize tobacco wastes. However, high levels of nicotine in discarded flue-cured tobacco leaves complicate tobacco waste composting. This work proposes a drying pretreatment process to reduce the nicotine content in discarded flue-cured tobacco leaves and thus enhance its carbon-to-nitrogen ratio to a suitable level for composting...
January 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28183675/mechanistic-investigation-on-microbial-toxicity-of-nano-hydroxyapatite-on-implant-associated-pathogens
#13
K Baskar, T Anusuya, G Devanand Venkatasubbu
The use of atomic scale inorganic nanoparticles (NPs) to fight against pathogenic microorganisms is a recent trend in biomedical area which overcomes the limitations of organic compounds in terms of stability, shelf life and bioactivity. One such Calcium phosphate based biomaterial is hydroxyapatite (HA), considered as potential bioactive compound with excellent biocompatibility, osteointegrity and biodegradability. Osteomyelitis, the implant associated infection, is the major problem worldwide responsible for the majority of implant failure cases...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183672/in-vitro-biocompatibility-of-a-ferrimagnetic-glass-ceramic-for-hyperthermia-application
#14
Oana Bretcanu, Marta Miola, Claudia L Bianchi, Ida Marangi, Roberta Carbone, Ingrid Corazzari, Mario Cannas, Enrica Verné
Ferrimagnetic glass-ceramics containing magnetite crystals were developed for hyperthermia applications of solid neoplastic tissue. The present work is focused on in vitro evaluation of the biocompatibility of these materials, before and after soaking in a simulated body fluid (SBF). X-ray diffraction, scanning electron microscopy, atomic absorption spectrophotometry, X-ray photoelectron spectrometry and pH measurements were employed in glass-ceramic characterisation. The free-radical mediated reactivity of the glass-ceramic was evaluated by Electron Paramagnetic Resonance (EPR) spin trapping...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183671/effect-of-phosphorus-precursors-on-the-structure-of-bioactive-calcium-phosphate-silicate-systems
#15
Katalin Sinkó, Anikó Meiszterics, János Rohonczy, Balázs Kobzi, Shiro Kubuki
The main aim of this work was to synthesize calcium phosphate silicate bioceramics by a low energy-consuming sol-gel method applying various phosphorous precursors (triethyl phosphate, phosphoric acid, and ammonium hydrogen phosphate). The investigations concentrated on the influence of phosphorous initial compounds on the bond and crystalline structures and the material quality. The application of the alkoxide and inorganic P-precursors results in considerably different textures. The inorganic PO4-containing precursors lead to sol formations...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183631/in-vitro-stimulation-of-vascular-endothelial-growth-factor-by-borate-based-glass-fibers-under-dynamic-flow-conditions
#16
Sisi Chen, Qingbo Yang, Richard K Brow, Kun Liu, Katherine A Brow, Yinfa Ma, Honglan Shi
Bioactive borate glass has been recognized to have both hard and soft tissue repair and regeneration capabilities through stimulating both osteogenesis and angiogenesis. However, the underlying biochemical and cellular mechanisms remain unclear. In this study, dynamic flow culturing modules were designed to simulate the micro-environment near the vascular depletion and hyperplasia area in wound-healing regions, thus to better investigate the mechanisms underlying the biocompatibility and functionality of borate-based glass materials...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183599/electrospun-curcumin-loaded-cellulose-acetate-polyvinylpyrrolidone-fibrous-materials-with-complex-architecture-and-antibacterial-activity
#17
Petya B Tsekova, Mariya G Spasova, Nevena E Manolova, Nadya D Markova, Iliya B Rashkov
Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluorescence microscopy, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), differential scanning calorimetry (DSC), water contact angle measurements, and microbiological tests. It was found that the incorporation of Curc into the CA and PVP solutions resulted in an increase of the solution viscosity and obtaining fibers with larger diameters (ca...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183011/semi-degradable-porous-poly-vinyl-alcohol-hydrogel-scaffold-for-cartilage-repair-evaluation-of-the-initial-and-cell-cultured-tribological-properties
#18
Yi Cao, Dangsheng Xiong, Kun Wang, Yuxiang Niu
Tissue engineering for articular cartilage repair has shown success in ensuring the integration of neocartilage with surrounding tissue, but the rapid restoration of biomechanical and biotribological functions remains a significant challenge. Poly (vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its fair mechanical strength and low surface friction, while its lack of bioactivity limits its utility. Combining the advantages of tissue engineering materials and PVA hydrogel, we developed a semi-degradable porous PVA hydrogel through addition of ploy (lactic-co-glycolic acid) (PLGA) microspheres and salt-leaching technique...
February 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28181831/basic-concepts-and-recent-advances-in-nanogels-as-carriers-for-medical-applications
#19
Iordana Neamtu, Alina Gabriela Rusu, Alina Diaconu, Loredana Elena Nita, Aurica P Chiriac
Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called as next generation drug delivery systems due to their relatively high drug encapsulation capacity, uniformity, tunable size, ease of preparation, minimal toxicity, stability in the presence of serum, and stimuli responsiveness. Nanogels show a great potential in chemotherapy, diagnosis, organ targeting and delivery of bioactive substances...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181476/biological-and-mechanical-evaluation-of-poly-lactic-co-glycolic-acid-based-composites-reinforced-with-one-two-and-three-dimensional-carbon-biomaterials-for-bone-tissue-regeneration
#20
Tejinder Kaur, Senthilguru Kulanthaivel, Thirugnanam Arunachalam, Indranil Banerjee, Krishna Pramanik
Considering the fact that life on earth is carbon based, carbon materials are being introduced in biological systems. However, very limited information is existing concerning the potential effects of different structures of carbon materials on biological systems. In the present study, poly(lactic-co-glycolic acid) (PLGA) based carbonaceous composites were developed by reinforcing 1 wt% of three different carbon based materials i.e. carbon nanotubes (CNTs-one dimensional), graphene nanoplatelets (GNPs-two dimensional) and activated carbon (AC-three dimensional)...
February 9, 2017: Biomedical Materials
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