Nicolas Serratrice, Laurie Bruzzese, Jérémy Magalon, Julie Véran, Laurent Giraudo, Houssein Aboudou, Djaffar Ould-Ali, Pierre Sébastien Nguyen, Olivier Bausset, Aurélie Daumas, Dominique Casanova, Brigitte Granel, Lucile Andrac-Meyer, Florence Sabatier, Guy Magalon
INTRODUCTION: Scleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and validated a model of scleroderma-like skin sclerosis in nude mice, appropriate to inject human derived products. We showed that the subcutaneous injection of micro-fat (MF), purified and injected using small caliber cannulas, have anti-fibrotic and pro-angiogenic effects and appears more suitable for the treatment of skin lesions of scleroderma compared to the gold standard (Coleman's technique or macro-fat)...
2014: Stem Cell Research & Therapy