keyword
https://read.qxmd.com/read/37692165/gut-microbiota-dysbiosis-characterized-by-abnormal-elevation-of-lactobacillus-in-patients-with-immune-mediated-necrotizing-myopathy
#1
JOURNAL ARTICLE
Xiuping Liang, Yanhong Li, Lu Cheng, Yinlan Wu, Tong Wu, Ji Wen, Deying Huang, Zehui Liao, Chunyu Tan, Yubin Luo, Yi Liu
AIM: The gut microbiota plays an important role in human health. In this study, we aimed to investigate whether and how gut microbiota communities are altered in patients with immune-mediated necrotizing myopathy (IMNM) and provide new ideas to further explore the pathogenesis of IMNM or screen for its clinical therapeutic targets in the future. METHODS: The gut microbiota collected from 19 IMNM patients and 23 healthy controls (HCs) were examined by using 16S rRNA gene sequencing...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37522862/patient-reported-quality-of-life-and-working-status-outcomes-in-ambulatory-patients-with-idiopathic-inflammatory-myopathy
#2
JOURNAL ARTICLE
Zhao Peng, Yanhong Wang, Ning Liu, Shuang Zhou, Jiuliang Zhao, Dong Xu, Mengtao Li, Chanyuan Wu, Xiaofeng Zeng, Qian Wang
OBJECTIVE: To investigate the health-related quality of life (HR-QoL), work productivity and activity impairment, and associated factors among patients with idiopathic inflammatory myopathy (IIM). METHODS: This was an observational, cross-sectional study. The 189 ambulatory patients with IIM were recruited from May 2019 to May 2022. HR-QoL was measured by the European Quality of Life 5-Dimension (EQ-5D). The work productivity and activity impairment (WPAI) questionnaire was used to evaluate work productivity and activity impairment...
July 31, 2023: Rheumatology
https://read.qxmd.com/read/37280166/plasma-pentraxin-3-in-idiopathic-inflammatory-myopathies-a-possible-new-biomarker-of-disease-activity
#3
JOURNAL ARTICLE
M Fornaro, F Girolamo, F Cacciapaglia, G Carabellese, R Bizzoca, C Scioscia, L Coladonato, G Lopalco, M Ruggieri, M Mastrapasqua, G Fari, D D'Abbicco, F Iannone
Pentraxin-3 (PTX3) is a component of humoral innate immunity with essential functions both in promotion and resolution of inflammation. We aimed to study the PTX3 in the plasma and in the muscle of patients with idiopathic inflammatory myopathies (IIM) and whether PTX3 may correlate with disease activity. Plasma PTX3 levels were assessed in 20 patients with IIMs, 10 Dermatomyositis (DM) and 10 Polymyositis (PM), compared to 10 patients with rheumatoid arthritis (RA) and 10 healthy donors (HDs) aged, sex and body mass index matched...
June 6, 2023: Clinical and Experimental Immunology
https://read.qxmd.com/read/37006269/type-i-interferon-score-is-associated-with-the-severity-and-poor-prognosis-in-anti-mda5-antibody-positive-dermatomyositis-patients
#4
JOURNAL ARTICLE
Jinjing Qian, Rui Li, Zhiwei Chen, Zehui Cao, Liangjing Lu, Qiong Fu
OBJECTIVES: To investigate the clinical significance of the interferon (IFN) score, especially the IFN-I score, in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (anti-MDA5+ DM). METHODS: We enrolled 262 patients with different autoimmune diseases, including idiopathic inflammatory myopathy, systemic lupus erythematosus, rheumatoid arthritis, adult-onset Still's disease, and Sjögren's syndrome, as well as 58 healthy controls...
2023: Frontiers in Immunology
https://read.qxmd.com/read/35404027/thromboembolic-events-in-idiopathic-inflammatory-myopathy-a-retrospective-study-in-china
#5
JOURNAL ARTICLE
Xixia Chen, Sizhuang Huang, Qiwen Jin, Yongpeng Ge, Jieping Lei, Zhenguo Huang, Lu Zhang, Guochun Wang
OBJECTIVE: To investigate the clinical characteristics and risk factors for thromboembolic events in patients with idiopathic inflammatory myopathy (IIM). METHODS: We retrospectively analyzed 1144 consecutive patients with IIM for arterial and venous thromboses and compared them with age- and sex-matched IIM patients without thrombosis. Logistic regression analysis was used to analyze risk factors for thrombosis. RESULTS: Twenty-four (2.1%) patients had arterial or venous thromboses (mean age, 62...
April 11, 2022: Clinical Rheumatology
https://read.qxmd.com/read/33369709/community-acquired-pneumonia-and-hospital-acquired-pneumonia-in-adult-patients-with-idiopathic-inflammatory-myopathy-outcome-and-antibiotic-therapy
#6
JOURNAL ARTICLE
Junyu Liang, Chuanyin Sun, Liqin Xu, Guanhua Xu, Heng Cao, Jin Lin
INTRODUCTION: Community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) are common complications in idiopathic inflammatory myopathy (IIM) patients, and are frequently associated with unfavorable outcome as well as prolonged antibiotic therapy. In this study, we intended to clarify whether clinical pulmonary infection score (CPIS) and multiple serum biomarkers are valuable in predicting unfavorable outcomes and prolonged antibiotic therapy in adult IIM patients complicated with CAP or HAP...
December 28, 2020: Rheumatology and Therapy
https://read.qxmd.com/read/32896262/circulating-tfh-cells-is-correlated-with-disease-activity-in-anti-mda5-antibody-positive-idiopathic-inflammatory-myopathies
#7
JOURNAL ARTICLE
Mianjing Zhou, Mengyuan Li, Chaohuan Guo, Shuang Wang, Xue Li, Siyuan Zhao, Hui Zhang, Niansheng Yang
OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a group of disorders characterised by the production of autoantibodies and inflammatory infiltrates in the skeletal muscles. Follicular T helper (TFH) cells are known to be crucial for B cell differentiation and autoantibody production in autoimmune diseases. The aim of this study was to investigate the involvement of TFH cells in IIM. METHODS: Circulating TFH cells in 44 IIM patients or 11 age- and gender-matched healthy controls (HCs) were measured by flow cytometry...
September 3, 2020: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/32774147/soluble-il-2-receptor-in-dermatomyositis-its-associations-with-skin-ulcers-and-disease-activity
#8
JOURNAL ARTICLE
Linrong He, Xiaoming Shu, Xia Liu, Yongpeng Ge, Sizhao Li, Xin Lu, Guochun Wang
Objective: To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods: Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay. Clinical features and laboratory data were collected from electronic medical record. Disease activity was evaluated by using physician global disease activity and myositis disease activity assessment visual analog scale (MYOACT) on admission...
2020: Mediators of Inflammation
https://read.qxmd.com/read/27171278/abnormally-increased-low-density-granulocytes-in-peripheral-blood-mononuclear-cells-are-associated-with-interstitial-lung-disease-in-dermatomyositis
#9
JOURNAL ARTICLE
Sigong Zhang, Haili Shen, Xiaoming Shu, Qinglin Peng, Guochun Wang
OBJECTIVE: We previously found that neutrophil extracellular traps (NETs) were associated with interstitial lung disease (ILD) in dermatomyositis (DM) patients. However, it is unclear whether low-density granulocytes (LDGs), endowed with enhanced NET formation capabilities, contribute to the pathogenesis of ILD. This study aims to elucidate the relationship between LDGs and DM-associated ILD. METHODS: We recruited 48 DM patients (28 with ILD) as well as 19 healthy volunteers for this study...
January 2017: Modern Rheumatology
https://read.qxmd.com/read/26509687/clinical-characteristics-of-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-antibodies-in-chinese-patients-with-idiopathic-inflammatory-myopathies
#10
JOURNAL ARTICLE
Yongpeng Ge, Xin Lu, Qinglin Peng, Xiaoming Shu, Guochun Wang
OBJECTIVE: The objective of this study was to detect the prevalence of anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and to analyze the clinical features of the antibody-positive IIM patients. METHODS: The presence of anti-HMGCR antibodies was detected in 405 patients with IIMs, 90 healthy controls, and 221 patients with other rheumatic diseases by using an ELISA kit...
2015: PloS One
https://read.qxmd.com/read/25417246/magnetic-resonance-imaging-changes-of-thigh-muscles-in-myopathy-with-antibodies-to-signal-recognition-particle
#11
JOURNAL ARTICLE
Yiming Zheng, Linlin Liu, Lu Wang, Jiangxi Xiao, Zhaoxia Wang, He Lv, Wei Zhang, Yun Yuan
OBJECTIVE: The aim of this study was to evaluate muscle MRI changes and the role of MRI in monitoring therapy in patients with myopathy associated with antibodies to signal recognition particle (anti-SRP myopathy). METHODS: We identified 12 patients with anti-SRP myopathy [6 females and 6 males; mean age of onset 38.5 years (s.d. 12.4), mean duration 22.8 months (s.d. 20.6). The main symptoms were proximal limb muscle weakness. Mean serum creatine kinase levels were moderately increased...
June 2015: Rheumatology
https://read.qxmd.com/read/25359220/the-metastasis-promoting-protein-s100a4-levels-associate-with-disease-activity-rather-than-cancer-development-in-patients-with-idiopathic-inflammatory-myopathies
#12
JOURNAL ARTICLE
Lenka Pleštilová, Heřman Mann, Lucie Andrés Cerezo, Ondřej Pecha, Jiří Vencovský, Ladislav Šenolt
INTRODUCTION: The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS: Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy controls. The associations between S100A4 levels, inflammation, disease activity, muscle strength and cancer development were evaluated. RESULTS: All myositis patients had significantly higher serum levels of S100A4 protein compared to healthy controls (median (IQR): 31...
October 31, 2014: Arthritis Research & Therapy
https://read.qxmd.com/read/24848429/prevalence-and-associated-factors-of-reduced-bone-mineral-density-in-patients-with-idiopathic-inflammatory-myopathies
#13
JOURNAL ARTICLE
Ho So, Man Lung Yip, Andrew Kui Man Wong
AIM: To determine the prevalence and identify the associated factors of reduced bone mineral density (BMD) in patients with idiopathic inflammatory myopathies (IIMs). METHOD: Existing patients diagnosed to have IIMs were recruited for measurement of BMD by dual energy X-ray absorptiometry. Demographic, clinical and treatment variables of these patients were recorded. The prevalence of osteopenia and osteoporosis were calculated. Using multivariate analysis, the independent associated factors for reduced BMD were evaluated...
May 2016: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/23557696/dyslipidaemia-in-juvenile-dermatomyositis-the-role-of-disease-activity
#14
JOURNAL ARTICLE
Katia T Kozu, Clovis A Silva, Eloisa Bonfá, Adriana M Sallum, Rosa M R Pereira, Vilma S Viana, Eduardo Borba, Lucia M Campos
OBJECTIVES: To evaluate the presence of dyslipidaemia in JDM and its possible risk factors. METHODS: Twenty-five JDM patients were compared to 25 healthy controls according to demographic data, body composition, fasting lipoproteins, glycaemia, insulin, antibodies and muscle enzymes. JDM scores were assessed: CMAS, MMT, DAS, MYOACT and MYTAX. RESULTS: Abnormal lipid profile was found in nine patients and four controls (36% vs. 16%, p=0.196)...
July 2013: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/18021522/disease-specific-quality-indicators-outcome-measures-and-guidelines-in-polymyositis-and-dermatomyositis
#15
JOURNAL ARTICLE
H Alexanderson, I E Lundberg
Polymyositis and dermatomyositis are chronic inflammatory muscle disorders with frequent involvement of other organs hence outcome measures should include these different aspects of disease. Muscle strength and muscle endurance are the most specific clinical features that should be assessed during treatment and longitudinal follow-up. Extramuscular involvement should also be assessed. An international, interdisciplinary network, the International Myositis Assessment Clinical Study Group (IMACS) has proposed a core set of outcome measures to assess three dimensions of myositis disease; disease activity (MYOACT), disease damage (MYODAM) and health related quality of life (SF-36) to be used in clinical trials...
November 2007: Clinical and Experimental Rheumatology
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