keyword
MENU ▼
Read by QxMD icon Read
search

mouse visual cortex

keyword
https://www.readbyqxmd.com/read/28319111/volumetric-two-photon-imaging-of-neurons-using-stereoscopy-vtwins
#1
Alexander Song, Adam S Charles, Sue Ann Koay, Jeff L Gauthier, Stephan Y Thiberge, Jonathan W Pillow, David W Tank
Two-photon laser scanning microscopy of calcium dynamics using fluorescent indicators is a widely used imaging method for large-scale recording of neural activity in vivo. Here, we introduce volumetric two-photon imaging of neurons using stereoscopy (vTwINS), a volumetric calcium imaging method that uses an elongated, V-shaped point spread function to image a 3D brain volume. Single neurons project to spatially displaced 'image pairs' in the resulting 2D image, and the separation distance between projections is proportional to depth in the volume...
March 20, 2017: Nature Methods
https://www.readbyqxmd.com/read/28290456/corrigendum-epileptiform-activity-in-the-mouse-visual-cortex-interferes-with-cortical-processing-in-connected-areas
#2
L Petrucco, E Pracucci, M Brondi, G M Ratto, S Landi
No abstract text is available yet for this article.
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28284708/visual-experience-regulates-the-development-of-long-term-synaptic-modifications-induced-by-low-frequency-stimulation-in-mouse-visual-cortex
#3
Taketoshi Sugimura, Mariko Yamamoto, Kazumasa Yamada, Yukio Komatsu, Yumiko Yoshimura
Manipulation of visual experience can considerably modify visual responses of visual cortical neurons even in adulthood in the mouse, although the modification is less profound than that observed during the critical period. Our previous studies demonstrated that low-frequency (2Hz) stimulation for 15min applied to layer 4 induces T-type Ca(2+) channel-dependent long-term potentiation (LTP) at excitatory synapses in layer 2/3 neurons of visual cortex during the critical period. In this study, we investigated whether low-frequency stimulation could induce synaptic plasticity in adult mice...
March 8, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28279352/gabaergic-neurons-in-ferret-visual-cortex-participate-in-functionally-specific-networks
#4
Daniel E Wilson, Gordon B Smith, Amanda L Jacob, Theo Walker, Jordane Dimidschstein, Gord Fishell, David Fitzpatrick
Functional circuits in the visual cortex require the coordinated activity of excitatory and inhibitory neurons. Molecular genetic approaches in the mouse have led to the "local non-specific pooling principle" of inhibitory connectivity, in which inhibitory neurons are untuned for stimulus features due to the random pooling of local inputs. However, it remains unclear whether this principle generalizes to species with a columnar organization of feature selectivity such as carnivores, primates, and humans. Here we use virally mediated GABAergic-specific GCaMP6f expression to demonstrate that inhibitory neurons in ferret visual cortex respond robustly and selectively to oriented stimuli...
March 8, 2017: Neuron
https://www.readbyqxmd.com/read/28273899/in-vivo-microscopic-voxel-based-morphometry-with-a-brain-template-to-characterize-strain-specific-structures-in-the-mouse-brain
#5
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J Okano, Hideyuki Okano
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice exhibit identical intra-strain genetics and divergent inter-strain phenotypes. The cognitive and behavioral divergences must be controlled by the variances of structure and function of their brains; however, the underlying morphological features of strain-to-strain difference remain obscure. Here, in vivo microscopic magnetic resonance imaging was optimized to image the mouse brains by using an isotropic resolution of 80 μm...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264980/locomotion-enhances-neural-encoding-of-visual-stimuli-in-mouse-v1
#6
Maria C Dadarlat, Michael P Stryker
Neurons in mouse primary visual cortex (V1) are selective for particular properties of visual stimuli. Locomotion causes a change in cortical state that leaves their selectivity unchanged but strengthens their responses. Both locomotion and the change in cortical state are thought to be initiated by projections from the mesencephalic locomotor region (MLR), the latter through a disinhibitory circuit in V1. By recording simultaneously from a large number of single neurons in alert mice viewing moving gratings, we investigated the relationship between locomotion and the information contained within the neural population...
March 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28256708/comparative-ultrastructural-features-of-excitatory-synapses-in-the-visual-and-frontal-cortices-of-the-adult-mouse-and-monkey
#7
Alexander Hsu, Jennifer I Luebke, Maria Medalla
The excitatory glutamatergic synapse is the principal site of communication between cortical pyramidal neurons and their targets, a key locus of action of many drugs, and highly vulnerable to dysfunction and loss in neurodegenerative disease. A detailed knowledge of the structure of these synapses in distinct cortical areas and across species is a prerequisite for understanding the anatomical underpinnings of cortical specialization and, potentially, selective vulnerability in neurological disorders. We used serial electron microscopy to assess the ultrastructural features of excitatory (asymmetric) synapses in the layers 2-3 (L2-3) neuropil of visual (V1) and frontal (FC) cortices of the adult mouse and compared findings to those in the rhesus monkey (V1 and lateral prefrontal cortex, LPFC)...
March 3, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28252109/gamma-band-activities-in-mouse-frontal-and-visual-cortex-induced-by-coherent-dot-motion
#8
Hio-Been Han, Eunjin Hwang, Soohyun Lee, Min-Shik Kim, Jee Hyun Choi
A key question within systems neuroscience is to understand how the brain encodes spatially and temporally distributed local features and binds these together into one perceptual representation. Previous works in animal and human have shown that changes in neural synchrony occur during the perceptual processing and these changes are distinguished by the emergence of gamma-band oscillations (GBO, 30-80 Hz, centered at 40 Hz). Here, we used the mouse electroencephalogram to investigate how different cortical areas play roles in perceptual processing by assessing their GBO patterns during the visual presentation of coherently/incoherently moving random-dot kinematogram and static dots display...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219725/planar-implantable-sensor-for-in-vivo-measurement-of-cellular-oxygen-metabolism-in-brain-tissue
#9
Vassiliy Tsytsarev, Fatih Akkentli, Elena Pumbo, Qinggong Tang, Yu Chen, Reha S Erzurumlu, Dmitri B Papkovsky
BACKGROUND: Brain imaging methods are continually improving. Imaging of the cerebral cortex is widely used in both animal experiments and charting human brain function in health and disease. Among the animal models, the rodent cerebral cortex has been widely used because of patterned neural representation of the whiskers on the snout and relative ease of activating cortical tissue with whisker stimulation. NEW METHOD: We tested a new planar solid-state oxygen sensor comprising a polymeric film with a phosphorescent oxygen-sensitive coating on the working side, to monitor dynamics of oxygen metabolism in the cerebral cortex following sensory stimulation...
February 20, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28203148/dopamine-d1-receptor-immunoreactivity-on-fine-processes-of-gfap-positive-astrocytes-in-the-substantia-nigra-pars-reticulata-of-adult-mouse
#10
Katsuhiro Nagatomo, Sechiko Suga, Masato Saitoh, Masahito Kogawa, Kazuto Kobayashi, Yoshio Yamamoto, Katsuya Yamada
Substantia nigra pars reticulata (SNr), the major output nucleus of the basal ganglia, receives dopamine from dendrites extending from dopaminergic neurons of the adjacent nucleus pars compacta (SNc), which is known for its selective degeneration in Parkinson's disease. As a recipient for dendritically released dopamine, the dopamine D1 receptor (D1R) is a primary candidate due to its very dense immunoreactivity in the SNr. However, the precise location of D1R remains unclear at the cellular level in the SNr except for that reported on axons/axon terminals of presumably striatal GABAergic neurons...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28194008/genetic-otx2-mis-localization-delays-critical-period-plasticity-across-brain-regions
#11
H H C Lee, C Bernard, Z Ye, D Acampora, A Simeone, A Prochiantz, A A Di Nardo, T K Hensch
Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period (CP) plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan recognition motif of Otx2 broadly delays the maturation of pivotal parvalbumin-positive (PV+) interneurons not only in V1 but also in the primary auditory (A1) and medial prefrontal cortex (mPFC). Consequently, not only visual, but also auditory plasticity is delayed, including the experience-dependent expansion of tonotopic maps in A1 and the acquisition of acoustic preferences in mPFC, which mitigates anxious behavior...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28177526/segregated-fronto-cortical-and-midbrain-connections-in-the-mouse-and-their-relation-to-approach-and-avoidance-orienting-behaviors
#12
Michael Anthony Savage, Richard McQuade, Alexander Thiele
The orchestration of orienting behaviors requires the interaction of many cortical and subcortical areas, for example the superior colliculus (SC), as well as prefrontal areas responsible for top-down control. Orienting involves different behaviors, such as approach and avoidance. In the rat, these behaviors are at least partially mapped onto different SC subdomains, the lateral (SCl) and medial (SCm), respectively. To delineate the circuitry involved in the two types of orienting behavior in mice, we injected retrograde tracer into the intermediate and deep layers of the SCm and SCl, and thereby determined the main input structures to these subdomains...
February 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28144216/a-tool-for-brain-wide-quantitative-analysis-of-molecular-data-upon-projection-into-a-planar-view-of-choice
#13
Samme Vreysen, Isabelle Scheyltjens, Marie-Eve Laramée, Lutgarde Arckens
Several techniques, allowing the reconstruction and visualization of functional, anatomical or molecular information from tissue and organ slices, have been developed over the years. Yet none allow direct comparison without reprocessing the same slices. Alternative methods using publicly available reference maps like the Allen Brain Atlas lack flexibility with respect to age and species. We propose a new approach to reconstruct a segmented region of interest from serial slices by projecting the optical density values representing a given molecular signal to a plane of view of choice, and to generalize the results into a reference map, which is built from the individual maps of all animals under study...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28130922/stimulus-relevance-modulates-contrast-adaptation-in-visual-cortex
#14
Andreas J Keller, Rachael Houlton, Björn M Kampa, Nicholas A Lesica, Thomas D Mrsic-Flogel, Georg B Keller, Fritjof Helmchen
A general principle of sensory processing is that neurons adapt to sustained stimuli by reducing their response over time. Most of our knowledge on adaptation in single cells is based on experiments in anesthetized animals. How responses adapt in awake animals, when stimuli may be behaviorally relevant or not, remains unclear. Here we show that contrast adaptation in mouse primary visual cortex depends on the behavioral relevance of the stimulus. Cells that adapted to contrast under anesthesia maintained or even increased their activity in awake naïve mice...
January 28, 2017: ELife
https://www.readbyqxmd.com/read/28123079/zika-virus-targeting-in-the-developing-brain
#15
Anthony N van den Pol, Guochao Mao, Yang Yang, Sara Ornaghi, John N Davis
Zika virus (ZIKV), a positive-sense RNA flavivirus, has attracted considerable attention recently for its potential to cause serious neurological problems, including microcephaly, cortical thinning, and blindness during early development. Recent findings suggest that ZIKV infection of the brain can occur not only during very early stages of development, but also in later fetal/early neonatal stages of maturation. Surprisingly, after peripheral inoculation of immunocompetent mice on the day of birth, the first cells targeted throughout the brain were isolated astrocytes...
February 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28123018/contribution-of-innate-cortical-mechanisms-to-the-maturation-of-orientation-selectivity-in-parvalbumin-interneurons
#16
Dario X Figueroa Velez, Kyle L Ellefsen, Ethan R Hathaway, Mathew C Carathedathu, Sunil P Gandhi
The maturation of cortical parvalbumin-positive (PV) interneurons depends on the interaction of innate and experience-dependent factors. Dark-rearing experiments suggest that visual experience determines when broad orientation selectivity emerges in visual cortical PV interneurons. Here, using neural transplantation and in vivo calcium imaging of mouse visual cortex, we investigated whether innate mechanisms contribute to the maturation of orientation selectivity in PV interneurons. First, we confirmed earlier findings showing that broad orientation selectivity emerges in PV interneurons by 2 weeks after vision onset, ∼35 d after these cells are born...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28122240/experience-dependent-equilibration-of-ampar-mediated-synaptic-transmission-during-the-critical-period
#17
Kyung-Seok Han, Samuel F Cooke, Weifeng Xu
Experience-dependent synapse refinement is essential for functional optimization of neural circuits. However, how sensory experience sculpts excitatory synaptic transmission is poorly understood. Here, we show that despite substantial remodeling of synaptic connectivity, AMPAR-mediated synaptic transmission remains at equilibrium during the critical period in the mouse primary visual cortex. The maintenance of this equilibrium requires neurogranin (Ng), a postsynaptic calmodulin-binding protein important for synaptic plasticity...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28122235/stability-and-plasticity-of-contextual-modulation-in-the-mouse-visual-cortex
#18
Adam Ranson
Activity of neurons in primary visual cortex is shaped by sensory and behavioral context. However, the long-term stability of the influence of contextual factors in the mature cortex remains poorly understood. To investigate this, we used two-photon calcium imaging to track the influence of surround suppression and locomotion on individual neurons over 14 days. We found that highly active excitatory neurons and parvalbumin-positive (PV+) interneurons exhibited relatively stable modulation by visual context...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28114886/application-of-hairless-mouse-strain-to-bioluminescence-imaging-of-arc-expression-in-mouse-brain
#19
Hironori Izumi, Tetsuya Ishimoto, Hiroshi Yamamoto, Hisashi Mori
BACKGROUND: Bioluminescence imaging (BLI) is a powerful technique for monitoring the temporal and spatial dynamics of gene expression in the mouse brain. However, the black fur, skin pigmentation and hair regrowth after depilation of mouse interfere with BLI during developmental and daily examination. The aim of this study was to extend the application of Arc-Luc transgenic (Tg) mice to the BLI of neuronal activity in the mouse brain by introducing the hairless (HL) gene and to examine Arc-Luc expression at various developmental stages without interference from black fur, skin pigmentation, and hair regrowth...
January 23, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28112643/layer-specific-chromatin-accessibility-landscapes-reveal-regulatory-networks-in-adult-mouse-visual-cortex
#20
Lucas T Gray, Zizhen Yao, Thuc Nghi Nguyen, Tae Kyung Kim, Hongkui Zeng, Bosiljka Tasic
Mammalian cortex is a laminar structure, with each layer composed of a characteristic set of cell types with different morphological, electrophysiological, and connectional properties. Here, we define chromatin accessibility landscapes of major, layer-specific excitatory classes of neurons, and compare them to each other and to inhibitory cortical neurons using the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq). We identify a large number of layer-specific accessible sites, and significant association with genes that are expressed in specific cortical layers...
January 23, 2017: ELife
keyword
keyword
120634
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"