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https://www.readbyqxmd.com/read/28093561/homeostatic-plasticity-mechanisms-in-mouse-v1
#1
REVIEW
Megumi Kaneko, Michael P Stryker
Mechanisms thought of as homeostatic must exist to maintain neuronal activity in the brain within the dynamic range in which neurons can signal. Several distinct mechanisms have been demonstrated experimentally. Three mechanisms that act to restore levels of activity in the primary visual cortex of mice after occlusion and restoration of vision in one eye, which give rise to the phenomenon of ocular dominance plasticity, are discussed. The existence of different mechanisms raises the issue of how these mechanisms operate together to converge on the same set points of activity...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28093553/enhancement-of-visual-cortex-plasticity-by-dark-exposure
#2
Irina Erchova, Asta Vasalauskaite, Valentina Longo, Frank Sengpiel
Dark rearing is known to delay the time course of the critical period for ocular dominance plasticity in the visual cortex. Recent evidence suggests that a period of dark exposure (DE) may enhance or reinstate plasticity even after closure of the critical period, mediated through modification of the excitatory-inhibitory balance and/or removal of structural brakes on plasticity. Here, we investigated the effects of a week of DE on the recovery from a month of monocular deprivation (MD) in the primary visual cortex (V1) of juvenile mice...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28093546/time-course-and-mechanisms-of-homeostatic-plasticity-in-layers-2-3-and-5-of-the-barrel-cortex
#3
Stanislaw Glazewski, Stuart Greenhill, Kevin Fox
Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFα. In this study, we tested whether a similar form of plasticity was present in layer 2/3 of the barrel cortex and, therefore, whether the mechanism was likely to be a general property of cortical neurons. We found that whisker deprivation could induce homeostatic plasticity in layer 2/3 of barrel cortex, but not in a mouse strain lacking synaptic scaling...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28078786/v1-connections-reveal-a-series-of-elongated-higher-visual-areas-in-the-california-ground-squirrel-otospermophilus-beecheyi
#4
Moritz Negwer, Yong-Jun Liu, Dirk Schubert, David C Lyon
For studies of visual cortex organization, mouse is becoming an increasingly more often used model. In addition to its genetic tractability, the relatively small area of cortical surface devoted to visual processing simplifies efforts in relating the structure of visual cortex to visual function. However, the nature of this compact organization can make some comparisons to the much larger non-human primate visual cortex difficult. The squirrel, as a highly visual rodent offers a useful means for better understanding how mouse and monkey cortical organization compares...
January 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28074441/activation-of-parvalbumin-positive-neurons-in-both-retina-and-primary-visual-cortex-improves-the-feature-selectivity-of-primary-visual-cortex-neurons
#5
Jinggang Duan, Hang Fu, Jiayi Zhang
Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive (PV(+)) neurons expressing channelrhodopsin-2 (ChR2) in the primary visual cortex (V1) improves the orientation- and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells (RGCs) and V1 neurons in ChR2(fl/+); PV-Cre mice...
January 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28072821/maysin-and-its-flavonoid-derivative-from-centipedegrass-attenuates-amyloid-plaques-by-inducting-humoral-immune-response-with-th2-skewed-cytokine-response-in-the-tg-appswe-ps1de9-alzheimer-s-mouse-model
#6
Yuno Song, Hong-Duck Kim, Min-Kwon Lee, Il-Hwa Hong, Chung-Kil Won, Hyoung-Woo Bai, Seung Sik Lee, SungBeom Lee, Byung Yeoup Chung, Jae-Hyeon Cho
Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models...
2017: PloS One
https://www.readbyqxmd.com/read/28071688/epileptiform-activity-in-the-mouse-visual-cortex-interferes-with-cortical-processing-in-connected-areas
#7
L Petrucco, E Pracucci, M Brondi, G M Ratto, S Landi
Epileptiform activity is associated with impairment of brain function even in absence of seizures, as demonstrated by failures in various testing paradigm in presence of hypersynchronous interictal spikes (ISs). Clinical evidence suggests that cognitive deficits might be directly caused by the anomalous activity rather than by its underlying etiology. Indeed, we seek to understand whether ISs interfere with neuronal processing in connected areas not directly participating in the hypersynchronous activity in an acute model of epilepsy...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060929/a-single-vector-platform-for-high-level-gene-transduction-of-central-neurons-adeno-associated-virus-vector-equipped-with-the-tet-off-system
#8
Jaerin Sohn, Megumu Takahashi, Shinichiro Okamoto, Yoko Ishida, Takahiro Furuta, Hiroyuki Hioki
Visualization of neurons is indispensable for the investigation of neuronal circuits in the central nervous system. Virus vectors have been widely used for labeling particular subsets of neurons, and the adeno-associated virus (AAV) vector has gained popularity as a tool for gene transfer. Here, we developed a single AAV vector Tet-Off platform, AAV-SynTetOff, to improve the gene-transduction efficiency, specifically in neurons. The platform is composed of regulator and response elements in a single AAV genome...
2017: PloS One
https://www.readbyqxmd.com/read/28059792/quantitative-comparison-of-dense-core-amyloid-plaque-accumulation-in-amyloid-%C3%AE-protein-precursor-transgenic-mice
#9
Peng Liu, John H Reichl, Eshaan R Rao, Brittany M McNellis, Eric S Huang, Laura S Hemmy, Colleen L Forster, Michael A Kuskowski, David R Borchelt, Robert Vassar, Karen H Ashe, Kathleen R Zahs
There exist several dozen lines of transgenic mice that express human amyloid-β protein precursor (AβPP) with Alzheimer's disease (AD)-linked mutations. AβPP transgenic mouse lines differ in the types and amounts of Aβ that they generate and in their spatiotemporal patterns of expression of Aβ assemblies, providing a toolkit to study Aβ amyloidosis and the influence of Aβ aggregation on brain function. More complete quantitative descriptions of the types of Aβ assemblies present in transgenic mice and in humans during disease progression should add to our understanding of how Aβ toxicity in mice relates to the pathogenesis of AD...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28059700/an-extended-retinotopic-map-of-mouse-cortex
#10
Jun Zhuang, Lydia Ng, Derric Williams, Matthew Valley, Yang Li, Marina Garrett, Jack Waters
Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosplenial cortices. Aligning retinotopic maps to architectonic borders, we found a mismatch in border location, indicating that architectonic borders are not aligned with the retinotopic transition at the vertical meridian...
January 6, 2017: ELife
https://www.readbyqxmd.com/read/28053039/complex-visual-motion-representation-in-mouse-area-v1
#11
Ganna Palagina, Jochen F Meyer, Stelios M Smirnakis
: Rodent visual cortex has a hierarchical architecture similar to that of higher mammals (Coogan and Burkhalter, 1993; Marshel et al., 2011; Wang et al., 2012). Although notable differences exist between the species in terms or receptive field sizes and orientation map organization (Dräger, 1975; Gattass et al., 1987; Van den Bergh et al., 2010), mouse V1 is thought to respond to local orientation and visual motion elements rather than to global patterns of motion, similar to V1 in higher mammals (Niell and Stryker, 2008; Bonin et al...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28046118/transcriptome-analysis-identifies-key-metabolic-changes-in-the-hooded-seal-cystophora-cristata-brain-in-response-to-hypoxia-and-reoxygenation
#12
Mariana Leivas Müller Hoff, Andrej Fabrizius, Nicole U Czech-Damal, Lars P Folkow, Thorsten Burmester
The brain of diving mammals tolerates low oxygen conditions better than the brain of most terrestrial mammals. Previously, it has been demonstrated that the neurons in brain slices of the hooded seal (Cystophora cristata) withstand hypoxia longer than those of mouse, and also tolerate reduced glucose supply and high lactate concentrations. This tolerance appears to be accompanied by a shift in the oxidative energy metabolism to the astrocytes in the seal while in terrestrial mammals the aerobic energy production mainly takes place in neurons...
2017: PloS One
https://www.readbyqxmd.com/read/28042098/age-dependent-alterations-in-neuronal-activity-in-the-hippocampus-and-visual-cortex-in-a-mouse-model-of-juvenile-neuronal-ceroid-lipofuscinosis-cln3
#13
Maria Burkovetskaya, Nikolay Karpuk, Tammy Kielian
Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a fatal lysosomal storage disease caused by autosomal recessive mutations in CLN3. JNCL is typified by progressive neurodegeneration that has been suggested to occur from excessive excitatory and impaired inhibitory synaptic input; however, no studies to date have directly evaluated neuronal function. To examine changes in neuronal activity with advancing disease, electrophysiological recordings were performed in the CA1 hippocampus (HPC) and visual cortex (VC) of acute brain slices from Cln3(Δex7/8) mice at 1, 4, 8, and 12months of age...
December 30, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/28033094/binocular-matching-of-thalamocortical-and-intracortical-circuits-in-the-mouse-visual-cortex
#14
Yu Gu, Jianhua Cang
Visual cortical neurons are tuned to similar orientations through the two eyes. The binocularly-matched orientation preference is established during a critical period in early life, but the underlying circuit mechanisms remain unknown. Here, we optogenetically isolated the thalamocortical and intracortical excitatory inputs to individual layer 4 neurons and studied their binocular matching. In adult mice, the thalamic and cortical inputs representing the same eyes are similarly tuned and both are matched binocularly...
December 29, 2016: ELife
https://www.readbyqxmd.com/read/28027309/novel-models-of-visual-topographic-map-alignment-in-the-superior-colliculus
#15
Ruben A Tikidji-Hamburyan, Tarek A El-Ghazawi, Jason W Triplett
The establishment of precise neuronal connectivity during development is critical for sensing the external environment and informing appropriate behavioral responses. In the visual system, many connections are organized topographically, which preserves the spatial order of the visual scene. The superior colliculus (SC) is a midbrain nucleus that integrates visual inputs from the retina and primary visual cortex (V1) to regulate goal-directed eye movements. In the SC, topographically organized inputs from the retina and V1 must be aligned to facilitate integration...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27986926/spatial-organization-of-chromatic-pathways-in-the-mouse-dorsal-lateral-geniculate-nucleus
#16
Daniel J Denman, Joshua H Siegle, Christof Koch, R Clay Reid, Timothy J Blanche
: In both dichromats and trichromats, cone opsin signals are maintained independently in cones and combined at the bipolar and retinal ganglion cell level creating parallel color-opponent pathways to the central visual system. Like other dichromats, the mouse retina expresses a short (S) and a medium (M) wavelength opsin, with the S-opsin shifted to peak sensitivity in the ultraviolet (UV) range. Unlike in primates, non-uniform opsin expression across the retina and co-expression in single cones creates a mostly mixed chromatic signal...
December 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27974161/mismatch-receptive-fields-in-mouse-visual-cortex
#17
Pawel Zmarz, Georg B Keller
In primary visual cortex, a subset of neurons responds when a particular stimulus is encountered in a certain location in visual space. This activity can be modeled using a visual receptive field. In addition to visually driven activity, there are neurons in visual cortex that integrate visual and motor-related input to signal a mismatch between actual and predicted visual flow. Here we show that these mismatch neurons have receptive fields and signal a local mismatch between actual and predicted visual flow in restricted regions of visual space...
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27956486/contribution-of-innate-cortical-mechanisms-to-the-maturation-of-orientation-selectivity-in-parvalbumin-interneurons
#18
Dario X Figueroa Velez, Kyle L Ellefsen, Ethan R Hathaway, Mathew C Carathedathu, Sunil P Gandhi
: The maturation of cortical Parvalbumin-positive (PV) interneurons depends on the interaction of innate and experience-dependent factors. Dark rearing experiments suggest that visual experience determines when broad orientation selectivity emerges in visual cortical PV interneurons. Here, using neural transplantation and in vivo calcium imaging of mouse visual cortex we investigate whether innate mechanisms contribute to the maturation of orientation selectivity in PV interneurons. First, we confirmed earlier findings showing that broad orientation selectivity emerges in PV interneurons by two weeks after vision onset, approximately 35 days after these cells are born...
December 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27929004/gamma-frequency-entrainment-attenuates-amyloid-load-and-modifies-microglia
#19
Hannah F Iaccarino, Annabelle C Singer, Anthony J Martorell, Andrii Rudenko, Fan Gao, Tyler Z Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G Canter, Richard Rueda, Emery N Brown, Edward S Boyden, Li-Huei Tsai
Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)1-40 and Aβ 1-42 isoforms...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27927787/functional-characterization-and-spatial-clustering-of-visual-cortical-neurons-in-the-predatory-grasshopper-mouse-onychomys-arenicola
#20
Benjamin Scholl, Jagruti J Pattadkal, Ashley Rowe, Nicholas J Priebe
Mammalian neocortical circuits are functionally organized such that the selectivity of individual neurons systematically shifts across the cortical surface, forming a continuous map. Maps of the sensory space exist in cortex, such as retinotopic maps in the visual system or tonotopic maps in the auditory system, but other functional response properties may also be similarly organized. For example, many carnivores and primates possess a map for orientation selectivity in primary visual cortex (V1), whereas mice, rabbits, and the gray squirrel lack orientation maps...
December 7, 2016: Journal of Neurophysiology
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