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Diabetes mellitus dog

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https://www.readbyqxmd.com/read/29056686/the-big-pet-diabetes-survey-perceived-frequency-and-triggers-for-euthanasia
#1
Stijn J M Niessen, Katarina Hazuchova, Sonya L Powney, Javier Guitian, Antonius P M Niessen, Paul D Pion, James A Shaw, David B Church
Current pet diabetes mellitus (DM) treatment necessitates the active daily involvement of owners and can be costly. The current study aimed to investigate the owner population which opts for euthanasia instead of DM treatment. A survey was designed using multiple feedback steps and made available online to veterinarians world-wide. A total of 1192 veterinarians completed the survey and suggested a median one in 10 diabetic pets are euthanased at diagnosis; a further median one in 10 within one year because of lack of success or compliance...
May 14, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/28944041/understanding-the-context-for-pet-cat-and-dog-feeding-and-exercising-behaviour-among-pet-owners-in-ireland-a-qualitative-study
#2
Martin J Downes, Catherine Devitt, Marie T Downes, Simon J More
BACKGROUND: Pet cat and dog obesity contributes to increased risk of several diseases, including cancer and diabetes mellitus as well as a worsening of orthopaedic problems, and a reduction in survival rate. This study aims to develop a better understanding of cat and dog owners' self-reported beliefs and factors that influence owner behaviour around feeding and exercising their pet cat or dog, as there is a lack of in-depth understanding in this area. Seven focus group discussions, with 43 pet owners in total, were conducted...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28903775/nonclinical-and-clinical-pharmacology-evidence-for-cardiovascular-safety-of-saxagliptin
#3
REVIEW
Pia S Pollack, Kristina D Chadwick, David M Smith, Martin Billger, Boaz Hirshberg, Nayyar Iqbal, David W Boulton
BACKGROUND: In the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR) trial in patients with type 2 diabetes mellitus (T2D) at high risk of cardiovascular (CV) disease, saxagliptin did not increase the risk for major CV adverse events. However, there was an unexpected imbalance in events of hospitalization for heart failure (hHF), one of six components of the secondary CV composite endpoint, with a greater number of events observed with saxagliptin...
September 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28892422/clinicopathologic-and-microbiologic-findings-associated-with-emphysematous-cystitis-in-27-dogs
#4
Lindsay Kate Merkel, Jody Lulich, David Polzin, Christopher Ober, Jodi Westropp, Jane Sykes
This is a retrospective case series of 27 dogs with emphysematous cystitis. Medical records from two veterinary teaching hospitals from 1992 to 2014 were reviewed. The aims of the study were to determine imaging findings, common underlying disease processes, and prevalent bacterial species and their antimicrobial susceptibility patterns in dogs with emphysematous cystitis. The most common lower urinary tract sign was hematuria. Gas was detected in the wall and lumen of the urinary bladder in 14 of 27 dogs (51...
November 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28863931/diabetes-mellitus-does-not-affect-the-neuromuscular-blocking-action-of-atracurium-in-dogs
#5
Elizabeth A Leece, Louise Clark
OBJECTIVE: To compare the duration of action of atracurium in diabetic and nondiabetic dogs. STUDY DESIGN: Prospective, blinded, clinical study. ANIMALS: A total of 26 diabetic and 29 nondiabetic dogs. METHODS: Following preanaesthetic medication and intravenous (IV) propofol induction, anaesthesia was maintained with isoflurane in oxygen. Atracurium 0.2 mg kg(-1) IV was administered to provide neuromuscular blockade (NMB) and the responses (twitches; T) to train-of-four nerve stimulation were recorded by palpation and electromyography (EMG)...
April 25, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28863873/evaluation-of-the-associations-between-immunoglobulin-e-levels-and-the-number-of-natural-teeth
#6
Kyungdo Han, Eunjoo Lee, Jun-Beom Park
BACKGROUND/PURPOSE: The purpose of the study was to evaluate the association between the number of natural teeth and the total serum immunoglobulin E (IgE), allergen-specific IgE against Dermatophagoides farina, allergen-specific IgE against cockroaches, or allergen-specific IgE against dogs with nationally representative data using the Korean National Health and Nutrition Examination Survey (KNHANES). METHODS: This study involved a cross-sectional analysis using KNHANES data from 2010...
August 29, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28842637/untargeted-metabolomic-analysis-in-naturally-occurring-canine-diabetes-mellitus-identifies-similarities-to-human-type-1-diabetes
#7
Allison L O'Kell, Timothy J Garrett, Clive Wasserfall, Mark A Atkinson
While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed serum metabolomic profiles of breed- and body weight-matched, diabetic (n = 6) and healthy (n = 6) dogs by liquid chromatography-mass spectrometry (LC-MS) profiling. We report distinct clustering of diabetic and control groups based on heat map analysis of known and unknown metabolites...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838299/peculiarities-of-feline-hyperadrenocorticism-update-on-diagnosis-and-treatment
#8
Lara A Boland, Vanessa R Barrs
Practical relevance: Hyperadrenocorticism (HAC) is a relatively uncommon endocrinopathy of older cats, with a mean age at diagnosis of 10 years. In addition to pituitary-dependent and adrenal-dependent hypercortisolism, clinical signs of HAC can result from adrenal sex steroid-producing tumours. Clinical challenges: While HAC in cats has many similarities to canine HAC, there are key differences in presentation, diagnosis and response to therapy. Most, but not all, cats with HAC have concurrent diabetes mellitus, which is often insulin resistant...
September 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28836097/animal-models-of-diabetic-retinopathy
#9
REVIEW
Ana Maria Olivares, Kristen Althoff, Gloria Fanghua Chen, Siqi Wu, Margaux A Morrisson, Margaret M DeAngelis, Neena Haider
PURPOSE OF REVIEW: Diabetic retinopathy (DR) is one of the most common complications associated with chronic hyperglycemia seen in patients with diabetes mellitus. While many facets of DR are still not fully understood, animal studies have contributed significantly to understanding the etiology and progression of human DR. This review provides a comprehensive discussion of the induced and genetic DR models in different species and the advantages and disadvantages of each model. RECENT FINDINGS: Rodents are the most commonly used models, though dogs develop the most similar morphological retinal lesions as those seen in humans, and pigs and zebrafish have similar vasculature and retinal structures to humans...
August 24, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28802947/canine-diabetes-mellitus-risk-factors-a-matched-case-control-study
#10
Alan Gomes Pöppl, Guilherme Luiz Carvalho de Carvalho, Itatiele Farias Vivian, Luis Gustavo Corbellini, Félix Hilário Díaz González
Different subtypes of canine diabetes mellitus (CDM) have been described based on their aetiopathogenesis. Therefore, manifold risk factors may be involved in CDM development. This study aims to investigate canine diabetes mellitus risk factors. Owners of 110 diabetic dogs and 136 healthy controls matched by breed, sex, and age were interviewed concerning aspects related to diet, weight, physical activity, oral health, reproductive history, pancreatitis, and exposure to exogenous glucocorticoids. Two multivariate multivariable statistical models were created: The UMod included males and females without variables related to oestrous cycle, while the FMod included only females with all analysed variables...
August 4, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28799185/punctate-retinal-hemorrhage-and-its-relation-to-ocular-and-systemic-disease-in-dogs-83-cases
#11
Nathaniel P Violette, Eric C Ledbetter
OBJECTIVE: To describe clinical aspects of dogs with punctate retinal hemorrhage (PRH). ANIMALS STUDIED: 83 dogs (119 eyes) with PRH. PROCEDURES: Medical records of dogs evaluated by the Cornell University ophthalmology service with a clinical diagnosis of PRH between 2006 and 2015 were reviewed. For this study, PRH was defined as retinal hemorrhages ≤ 1 optic disk diameter in size and dogs with other posterior segment ocular diseases were excluded...
August 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28759861/concurrent-hyperadrenocorticism-and-diabetes-mellitus-in-dogs
#12
D D Miceli, O P Pignataro, V A Castillo
Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and DM, and the risk factors involved that could contribute to the development of DM in dogs with HAC. A total of 235 dogs with HAC were studied and, according to their fasting glycemia, they were divided into three groups: <5.6mmol/L, between 5.6 and 10.08mmol/L and >10.08mmol/L. The following parameters were evaluated: age, gender, cause of HAC, body condition, glycemia, total cholesterol, triglycerides, urinary cortisol:creatinin ratio (UCCR) and survival time...
July 25, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28467694/durable-control-of-autoimmune-diabetes-in-mice-achieved-by-intraperitoneal-transplantation-of-neo-islets-three-dimensional-aggregates-of-allogeneic-islet-and-mesenchymal-stem-cells
#13
Christof Westenfelder, Anna Gooch, Zhuma Hu, Jon Ahlstrom, Ping Zhang
Novel interventions that reestablish endogenous insulin secretion and thereby halt progressive end-organ damage and prolong survival of patients with autoimmune Type 1 diabetes mellitus (T1DM) are urgently needed. While this is currently accomplished with allogeneic pancreas or islet transplants, their utility is significantly limited by both the scarcity of organ donors and life-long need for often-toxic antirejection drugs. Coadministering islets with bone marrow-derived mesenchymal stem cells (MSCs) that exert robust immune-modulating, anti-inflammatory, anti-apoptotic, and angiogenic actions, improves intrahepatic islet survival and function...
May 3, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28460795/obesity-and-associated-comorbidities-in-people-and-companion-animals-a-one-health-perspective
#14
REVIEW
M Chandler, S Cunningham, E M Lund, C Khanna, R Naramore, A Patel, M J Day
This article reviews the biology, prevalence and risks for obesity in people and companion dogs and cats, and explores the links between obesity and diabetes mellitus and cancer across these species. Obesity is a major healthcare problem in both human and veterinary medicine and there is an increasing prevalence of obesity in people and pets. In people and animals, obesity is a complex disorder involving diet, level of physical activity, behavioural factors, socioeconomic factors, environment exposures, genetics, metabolism and the microbiome...
May 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28452143/zy15557-a-novel-long-acting-inhibitor-of-dipeptidyl-peptidase-4-for-the-treatment-of-type-2-diabetes-mellitus
#15
Mukul R Jain, Amit A Joharapurkar, Samadhan G Kshirsagar, Vishal J Patel, Rajesh H Bahekar, Harilal V Patel, Pradip A Jadav, Pankaj R Patel, Ranjit C Desai
BACKGROUND AND PURPOSE: Dipeptidyl peptidase (DPP)-4 inhibitors increase levels of glucagon-like peptide-1 (GLP-1) and provide clinical benefit in the treatment of type 2 diabetes mellitus. As longer acting inhibitors have therapeutic advantages, we developed a novel DPP-4 inhibitor, ZY15557, that has a sustained action and long half-life. EXPERIMENTAL APPROACH: We studied the potency, selectivity, efficacy and duration of action of ZY15557, in vitro, with assays of DPP-4 activity...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28387422/validation-and-determination-of-a-reference-interval-for-canine-hba1c-using-an-immunoturbidimetric-assay
#16
Anne F Goemans, Susanna J Spence, Ian K Ramsey
BACKGROUND: Hemoglobin A1c (HbA1c) provides a reliable measure of glycemic control over 2-3 months in human diabetes mellitus. In dogs, presence of HbA1c has been demonstrated, but there are no validated commercial assays. OBJECTIVE: The purpose of the study was to validate a commercially available automated immunoturbidimetric assay for canine HbA1c and determine an RI in a hospital population. METHODS: The specificity of the assay was assessed by inducing glycosylation in vitro using isolated canine hemoglobin, repeatability by measuring canine samples 5 times in succession, long term inter-assay imprecision by measuring supplied control materials, stability using samples stored at 4°C over 5 days and -20°C over 8 weeks, linearity by mixing samples of known HbA1c in differing proportions, and the effect of anticoagulants with paired samples...
June 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28266313/development-of-a-plasminogen-activator-inhibitor-pai-1-assay-and-comparison-of-plasma-pai-1-activity-in-hyperlipidemic-dyslipidemic-dogs-with-either-hyperadrenocorticism-or-diabetes-mellitus-and-healthy-dogs
#17
Cheryl J Wong, Michael Koch, Erica L Behling-Kelly
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-thrombosis and abnormal lipid metabolism. Our objective was to develop and validate a canine PAI-1 activity assay and test whether dogs with hyperadrenocorticism or diabetes mellitus that are hyperlipidemic/dyslipidemic have increased plasma PAI-1 activity. Functionally active PAI-1 in the plasma sample was incubated with recombinant tissue plasminogen activator (tPA), allowing the formation of a 1:1 stoichiometric inactive complex...
April 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28180095/tgf-%C3%AE-1-serum-concentrations-and-receptor-expressions-in-the-lens-capsular-of-dogs-with-diabetes-mellitus
#18
Stephan Neumann, Jens Linek, Gerhard Loesenbeck, Julia Schüttler, Sonja Gaedke
Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations. TGF-β1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with fibrotic diseases...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28176381/the-canine-pomc-gene-obesity-in-labrador-retrievers-and-susceptibility-to-diabetes-mellitus
#19
L J Davison, A Holder, B Catchpole, C A O'Callaghan
BACKGROUND: Diabetes mellitus (DM) in dogs is a common endocrinopathy with a complex genetic architecture. Disease susceptibility in several breeds is associated with polymorphisms in immune response genes, but in the Labrador retriever breed, no genetic associations with DM have been identified. A deletion in the pro-opiomelanocortin (POMC) gene in Labrador retrievers is associated with increased appetite and risk of obesity. HYPOTHESIS/OBJECTIVES: To characterize the POMC deletion in Labrador retrievers, to develop a simple genetic test for this mutation, and to test the hypothesis that the POMC gene deletion is associated with an increased risk of DM in this breed...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27847521/pasteurella-multocida-bacteremia-in-an-immunocompromised-patient
#20
Shweta Kukrety, Jai Parekh, Theresa Townley
We present the case of a 61-year-old Caucasian gentleman who presented with a one-day history of fever, chills, and altered mental status. His symptoms were initially thought to be secondary to cellulitis. Blood cultures grew Pasteurella multocida, a rare pathogen to cause bacteremia. Our patient was treated with ciprofloxacin for two weeks and made a complete and uneventful recovery. Our patient's uncontrolled diabetes mellitus and chronic kidney disease put him at a higher risk for developing serious P. multocida infection...
2016: Case Reports in Medicine
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