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Diabetes mellitus dog

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https://www.readbyqxmd.com/read/28387422/validation-and-determination-of-a-reference-interval-for-canine-hba1c-using-an-immunoturbidimetric-assay
#1
Anne F Goemans, Susanna J Spence, Ian K Ramsey
BACKGROUND: Hemoglobin A1c (HbA1c) provides a reliable measure of glycemic control over 2-3 months in human diabetes mellitus. In dogs, presence of HbA1c has been demonstrated, but there are no validated commercial assays. OBJECTIVE: The purpose of the study was to validate a commercially available automated immunoturbidimetric assay for canine HbA1c and determine an RI in a hospital population. METHODS: The specificity of the assay was assessed by inducing glycosylation in vitro using isolated canine hemoglobin, repeatability by measuring canine samples 5 times in succession, long term inter-assay imprecision by measuring supplied control materials, stability using samples stored at 4°C over 5 days and -20°C over 8 weeks, linearity by mixing samples of known HbA1c in differing proportions, and the effect of anticoagulants with paired samples...
April 7, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28266313/development-of-a-plasminogen-activator-inhibitor-pai-1-assay-and-comparison-of-plasma-pai-1-activity-in-hyperlipidemic-dyslipidemic-dogs-with-either-hyperadrenocorticism-or-diabetes-mellitus-and-healthy-dogs
#2
Cheryl J Wong, Michael Koch, Erica L Behling-Kelly
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-thrombosis and abnormal lipid metabolism. Our objective was to develop and validate a canine PAI-1 activity assay and test whether dogs with hyperadrenocorticism or diabetes mellitus that are hyperlipidemic/dyslipidemic have increased plasma PAI-1 activity. Functionally active PAI-1 in the plasma sample was incubated with recombinant tissue plasminogen activator (tPA), allowing the formation of a 1:1 stoichiometric inactive complex...
April 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28180095/tgf-%C3%AE-1-serum-concentrations-and-receptor-expressions-in-the-lens-capsular-of-dogs-with-diabetes-mellitus
#3
Stephan Neumann, Jens Linek, Gerhard Loesenbeck, Julia Schüttler, Sonja Gaedke
Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations. TGF-β1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with fibrotic diseases...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28176381/the-canine-pomc-gene-obesity-in-labrador-retrievers-and-susceptibility-to-diabetes-mellitus
#4
L J Davison, A Holder, B Catchpole, C A O'Callaghan
BACKGROUND: Diabetes mellitus (DM) in dogs is a common endocrinopathy with a complex genetic architecture. Disease susceptibility in several breeds is associated with polymorphisms in immune response genes, but in the Labrador retriever breed, no genetic associations with DM have been identified. A deletion in the pro-opiomelanocortin (POMC) gene in Labrador retrievers is associated with increased appetite and risk of obesity. HYPOTHESIS/OBJECTIVES: To characterize the POMC deletion in Labrador retrievers, to develop a simple genetic test for this mutation, and to test the hypothesis that the POMC gene deletion is associated with an increased risk of DM in this breed...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27847521/pasteurella-multocida-bacteremia-in-an-immunocompromised-patient
#5
Shweta Kukrety, Jai Parekh, Theresa Townley
We present the case of a 61-year-old Caucasian gentleman who presented with a one-day history of fever, chills, and altered mental status. His symptoms were initially thought to be secondary to cellulitis. Blood cultures grew Pasteurella multocida, a rare pathogen to cause bacteremia. Our patient was treated with ciprofloxacin for two weeks and made a complete and uneventful recovery. Our patient's uncontrolled diabetes mellitus and chronic kidney disease put him at a higher risk for developing serious P. multocida infection...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27608692/pancreas-and-diabetes-mellitus-the-relationship-between-the-organ-and-the-disease
#6
REVIEW
Saumya Menon, Gopalakrishna Rajesh, Vallath Balakrishnan
Diabetes mellitus has been a fascinating disease from the dawn of medical history. The first breakthrough in its treatment came in 1922, with the discovery of insulin which was extracted from the pancreas of a dog. Even earlier, a relationship between pancreas and diabetes mellitus had been suspected by medical scientists. However, the study of diabetes mellitus is much more than its relationship with the pancreas. On the other hand the pancreas has been known to be a very reclusive organ that is hidden away from physicians and surgeons for centuries...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27461721/what-s-in-a-name-classification-of-diabetes-mellitus-in-veterinary-medicine-and-why-it-matters
#7
C Gilor, S J M Niessen, E Furrow, S P DiBartola
Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical manifestations of DM are not indicative of the cause of the disease, but might be indicative of the stage and severity of the disease process. Accurately diagnosing and classifying diabetic dogs and cats by the underlying disease process is essential for current and future studies on early detection, prevention, and treatment of underlying disease. Here, we review the current etiology-based classification of DM and definitions of DM types in human medicine and discuss key points on the pathogenesis of each DM type and prediabetes...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27352988/infectious-crystalline-keratopathy-in-dogs-and-cats-clinical-in-vivo-confocal-microscopic-histopathologic-and-microbiologic-features-of-eight-cases
#8
Eric C Ledbetter, Patrick L McDonough, Kay Kim
OBJECTIVE: To describe clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of canine and feline cases of infectious crystalline keratopathy (ICK). ANIMALS STUDIED: Six dogs and two cats with naturally acquired ICK. PROCEDURES: Medical records of dogs and cats with a clinical diagnosis of ICK were reviewed. Signalment, medical history, clinical findings, and diagnostic evaluations were retrieved, including corneal cytology, histopathology, in vivo confocal microscopy, and microbiology results...
June 29, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27298192/pharmacological-profiles-of-gemigliptin-lc15-0444-a-novel-dipeptidyl-peptidase-4-inhibitor-in-vitro-and-in-vivo
#9
Sung-Ho Kim, Eunsoo Jung, Min Kyung Yoon, O Hwan Kwon, Dal-Mi Hwang, Dong-Wook Kim, Junghyun Kim, Sun-Mee Lee, Hyeon Joo Yim
Gemigliptin, a novel dipeptidyl peptidase (DPP)-4 inhibitor, is approved for use as a monotherapy or in combination therapy to treat hyperglycemia in patients with type 2 diabetes mellitus. In this study, we investigated the pharmacological profiles of gemigliptin in vitro and in vivo and compared them to those of the other DPP-4 inhibitors. Gemigliptin was a reversible and competitive inhibitor with a Ki value of 7.25±0.67nM. Similar potency was shown in plasma from humans, rats, dogs, and monkeys. The kinetics of DPP-4 inhibition by gemigliptin was characterized by a fast association and a slow dissociation rate compared to sitagliptin (fast on and fast off rate) or vildagliptin (slow on and slow off rate)...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27297495/metabolic-effects-of-obesity-and-its-interaction-with-endocrine-diseases
#10
REVIEW
Melissa Clark, Margarethe Hoenig
Obesity in pet dogs and cats is a significant problem in developed countries, and seems to be increasing in prevalence. Excess body fat has adverse metabolic consequences, including insulin resistance, altered adipokine secretion, changes in metabolic rate, abnormal lipid metabolism, and fat accumulation in visceral organs. Obese cats are predisposed to endocrine and metabolic disorders such as diabetes and hepatic lipidosis. A connection likely also exists between obesity and diabetes mellitus in dogs. No system has been developed to identify obese pets at greatest risk for development of obesity-associated metabolic diseases, and further study in this area is needed...
September 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27290774/dogs-for-diabetes
#11
David Spero
No abstract text is available yet for this article.
May 2016: Diabetes Self-management
https://www.readbyqxmd.com/read/27246633/study-of-the-pathogenesis-and-treatment-of-diabetes-mellitus-through-animal-models
#12
Yeray Brito-Casillas, Carlos Melián, Ana María Wägner
Most research in diabetes mellitus (DM) has been conducted in animals, and their replacement is currently a chimera. As compared to when they started to be used by modern science in the 17th century, a very high number of animal models of diabetes is now available, and they provide new insights into almost every aspect of diabetes. Approaches combining human, in vitro, and animal studies are probably the best strategy to improve our understanding of the underlying mechanisms of diabetes, and the choice of the best model to achieve such objective is crucial...
August 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27228235/long-term-follow-up-of-renal-function-assessing-serum-cystatin-c-in-dogs-with-diabetes-mellitus-or-hyperadrenocorticism
#13
Sofie J J Marynissen, Pascale M Y Smets, Liesbeth F E Ghys, Dominique Paepe, Joris Delanghe, Sara Galac, Evelyne Meyer, Hervé P Lefebvre, Sylvie Daminet
BACKGROUND: Serum cystatin C (sCysC) is used as biomarker for glomerular filtration rate (GFR). The effects of diabetes mellitus (DM) on renal function in dogs are unclear. Some renal variables have been evaluated in dogs with hyperadrenocorticism (HAC), but not sCysC. OBJECTIVES: The purpose of this study was the validation of a particle-enhanced nephelometric immunoassay (PENIA) for measuring canine sCysC, and to assess renal function in dogs with DM or HAC. METHODS: A PENIA was analytically validated for canine sCysC by determining imprecision and linearity...
June 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27203422/canine-fibroblast-growth-factor-21-ameliorates-hyperglycemia-associated-with-inhibiting-hepatic-gluconeogenesis-and-improving-pancreatic-beta-cell-survival-in-diabetic-mice-and-dogs
#14
Pengfei Xu, Yingjie Zhang, Xinghao Jiang, Junyan Li, Liying Song, Mir Hasson Khoso, Yunye Liu, Qiang Wu, Guiping Ren, Deshan Li
Diabetes mellitus is a common endocrinopathy in dog. Fibroblast growth factor 21 (FGF-21) is a secreted protein, which is involved in glucose homeostasis. We speculate that the recombinant canine FGF-21 (cFGF-21) has the potential to become a powerful therapeutics to treat canine diabetes. The cFGF-21 gene was cloned and expressed in E. coli Rosetta (DE3). After purification, a cFGF-21 protein with the purity exceeding 95% was obtained. Mouse 3T3-L1 adipocytes and type 1 diabetic mice/dogs induced by STZ were used to examine the biological activity of cFGF-21 in vitro and in vivo, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27189100/quantification-of-nitrergic-neurons-in-the-myenteric-plexus-of-gastric-antrum-and-ileum-of-healthy-and-diabetic-dogs
#15
F Giancola, F Fracassi, A Gallucci, J Sadeghinezhad, G Polidoro, E Zini, M Asti, R Chiocchetti
Diabetes mellitus (DM) determines a wide array of severe clinical complications including gastrointestinal motility disorders. The present study investigates the effects of spontaneous DM on the intramural innervation and in particular on nitrergic neurons of the myenteric plexus (MP) of the canine gastric antrum and ileum. Specimens of antrum and ileum from eight control-dogs and five insulin-dependent DM-dogs were collected. MP neurons were immunohistochemically identified with the anti-HuC/HuD antibody, while nitrergic neurons were identified with the antibody anti-neuronal nitric oxide synthase (nNOS)...
May 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27102270/aldose-reductase-ocular-diabetic-complications-and-the-development-of-topical-kinostat-%C3%A2
#16
REVIEW
Peter F Kador, Milton Wyman, Peter J Oates
Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact of DM on ocular tissues because inadequate glycemic control leads to ocular tissue changes that range from a temporary blurring of vision to permanent vision loss. The biochemical mechanisms that promote the development of diabetic complications have been extensively studied. As a result, a number of prominent biochemical pathways have been identified...
September 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27075106/beta-hydroxybutyrate-concentrations-in-dogs-with-acute-pancreatitis-and-without-diabetes-mellitus
#17
F E Hurrell, K J Drobatz, R S Hess
BACKGROUND: β-hydroxybutyrate (BOHB) concentrations have not been quantified in dogs with acute pancreatitis (AP). OBJECTIVE: The aim of this study was to investigate BOHB concentrations in dogs with AP. ANIMALS: A total of 154 client-owned dogs without DM. METHODS: Prospective clinical study. Dogs were enrolled into 1 of 3 groups: AP, sick without an AP diagnosis, or fasted. Dogs were diagnosed with AP (44) if they had vomiting or anorexia, and either ultrasonographic findings consistent with AP or increased pancreatic lipase...
May 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27061240/epidemiology-and-clinical-presentation-of-canine-cataracts-in-france-a-retrospective-study-of-404-cases
#18
Elise Donzel, Léa Arti, Sabine Chahory
OBJECTIVE: To determine the epidemiology and the clinical presentation of cataracts in a population of dogs in France. PROCEDURES: Records of dogs affected by a cataract presented at the Ophthalmology Unit of Alfort Veterinary School during 2009-2012 were reviewed. The etiology was determined for each dog. The signalment of affected dogs, their medical history, age of onset, stage of progression, location of opacities, and ocular lesions associated were evaluated for each etiology...
March 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27031512/anti-insulin-immune-responses-are-detectable-in-dogs-with-spontaneous-diabetes
#19
Jong-Hyuk Kim, Eva Furrow, Michelle G Ritt, Paul J Utz, William H Robinson, Liping Yu, Andrea Eckert, Kathleen Stuebner, Timothy D O'Brien, Lawrence Steinman, Jaime F Modiano
Diabetes mellitus occurs spontaneously in dogs. Although canine diabetes shares many features with human type-1 diabetes, there are differences that have cast doubt on the immunologic origin of the canine disease. In this study, we examined whether peripheral immune responses directed against islet antigens were present in dogs with diabetes. Routine diagnostics were used to confirm diabetic status, and serum samples from dogs with (N = 15) and without (N = 15) diabetes were analyzed for the presence of antibodies against islet antigens (insulin, glutamic acid decarboxylase, insulinoma-associated protein tyrosine phosphatase, and islet beta-cell zinc cation efflux transporter) using standard radioassays...
2016: PloS One
https://www.readbyqxmd.com/read/26967920/topical-composition-for-treating-diabetic-cataracts-a-patent-evaluation-wo2015026380a1
#20
Xin Hao, Zhongfei Han, Changjin Zhu
Diabetes mellitus is a major threat to global public health that requires long-term medical attention. In view of the potentially devastating effects of diabetes on ocular health, it highlights the urgent need of therapeutic drugs for the prevention and treatment of the diabetic complications. The patent described in this evaluation (WO2015026380A1) claimed a topical composition for treating diabetic cataracts both in animals and human beings. The composition containing a therapeutic amount of the 2R-methyl sorbinil, one of aldose reductase inhibitors, delivered to the dog's eye can exert a preventive, inhibitory, or prophylactic effect on diabetic cataracts in a statistically significant portion of the population being studied...
June 2016: Expert Opinion on Therapeutic Patents
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