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Diabetes mellitus dog

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https://www.readbyqxmd.com/read/29680393/validation-reference-intervals-and-overlap-performance-of-a-new-commercially-available-automated-capillary-electrophoresis-assay-for-the-determination-of-the-major-fraction-of-glycated-haemoglobin-hba1c-in-dogs
#1
I L Oikonomidis, T K Tsouloufi, N Soubasis, M Kritsepi-Konstantinou
Haemoglobin A1c (HbA1c), the major fraction of glycated haemoglobin, is widely used for the diagnosis and monitoring of diabetes mellitus in human beings. However, there is a paucity of literature on the most reliable methods available for measurement of canine HbA1c. The aim of this study was to validate a new automated capillary electrophoresis assay for canine HbA1c, to generate a reference interval and to assess the overlap performance of the assay for the diagnosis of diabetes mellitus. Eighty-three blood samples treated with EDTA were included in the study, comprising 63 from healthy dogs and 20 from diabetic dogs...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29665152/endothelium-derived-hyperpolarization-mediated-vasodilatation-compensates-nitric-oxide-mediated-endothelial-dysfunction-during-ischemia-in-diabetes-induced-canine-coronary-collateral-microcirculation-in-vivo
#2
Toyotaka Yada, Hiroaki Shimokawa, Hiroyuki Tachibana
OBJECTIVES: It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-derived hyperpolarizing-mediated responses to compensate reduced NO-mediated responses in diabetes mellitus during coronary occlusion in dogs in vivo. METHODS: Canine subepicardial collateral coronary small arteries (≥100 μm) and arterioles (<100 μm) were observed by an intravital microscope...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29574025/effects-of-multi-electrode-renal-denervation-on-insulin-sensitivity-and-glucose-metabolism-in-a-canine-model-of-type-2-diabetes-mellitus
#3
Tao Pan, Jin-He Guo, Long Ling, Yue Qian, Yong-Hua Dong, Hua-Qing Yin, Hai-Dong Zhu, Gao-Jun Teng
PURPOSE: To evaluate the effects of multi-electrode catheter-based renal denervation (RDN) on insulin sensitivity and glucose metabolism in a type 2 diabetes mellitus (T2DM) canine model. MATERIALS AND METHODS: Thirty-three dogs were divided equally into 3 groups: bilateral renal denervation (BRDN) group, left renal denervation (LRDN) group, and sham operation (SHAM) group. Body weight and blood biochemistry were measured at baseline, 20 weeks, and 32 weeks, and renal angiography and computerized tomographic (CT) angiography were determined before the procedure and 1 month, 2 months, and 3 months after the procedure...
March 21, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29422615/house-dust-mite-and-cockroach-specific-immunoglobulin-e-sensitization-is-associated-with-diabetes-mellitus-in-the-adult-korean-population
#4
Mee Kyoung Kim, Jee Sun Jeong, Kyungdo Han, Ki Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Immunoglobulin E (IgE) is known to activate mast cells. Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM). We aimed to determine whether adults with IgE sensitization were at risk of DM. We performed assays regarding serum total IgE and allergen-specific IgE levels against the house dust mite, the cockroach, and the dog on 1,528 adults randomly sampled from every age and gender group in various districts. The total and three allergen-specific IgE levels were positively correlated with fasting glucose level and insulin resistance...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29371812/azole-resistance-caused-by-increased-drug-efflux-in-candida-glabrata-isolated-from-the-urinary-tract-of-a-dog-with-diabetes-mellitus
#5
Minchul Kim, Hyekyung Lee, Sun-Young Hwang, Inhyung Lee, Won Hee Jung
A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1 , is the main cause of azole resistance of the C...
December 2017: Mycobiology
https://www.readbyqxmd.com/read/29314873/2018-aaha-diabetes-management-guidelines-for-dogs-and-cats
#6
Ellen Behrend, Amy Holford, Patty Lathan, Renee Rucinsky, Rhonda Schulman
Diabetes mellitus (DM) is a common disease encountered in canine and feline medicine. The 2018 AAHA Diabetes Management Guidelines for Dogs and Cats revise and update earlier guidelines published in 2010. The 2018 guidelines retain much of the information in the earlier guidelines that continues to be applicable in clinical practice, along with new information that represents current expert opinion on controlling DM. An essential aspect of successful DM management is to ensure that the owner of a diabetic dog or cat is capable of administering insulin, recognizing the clinical signs of inadequately managed DM, and monitoring blood glucose levels at home, although this is ideal but not mandatory; all topics that are reviewed in the guidelines...
January 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29193277/spectrophotometry-and-ultracentrifugation-for-measurement-of-plasma-lipids-in-dogs-with-diabetes-mellitus
#7
E C Seage, K J Drobatz, R S Hess
BACKGROUND: There are conflicting reports of plasma lipoprotein lipid content in dogs with diabetes mellitus (DM). OBJECTIVES: To determine lipoprotein lipid content of plasma of dogs with DM by spectrophotometry and ultracentrifugation; to compare lipoprotein lipid content in diabetic and healthy dogs; and to quantify apolipoprotein B-100 (ApoB) in dogs with DM. ANIMALS: 22 dogs with DM and 9 healthy dogs. METHODS: Cross-sectional study...
January 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29056686/the-big-pet-diabetes-survey-perceived-frequency-and-triggers-for-euthanasia
#8
Stijn J M Niessen, Katarina Hazuchova, Sonya L Powney, Javier Guitian, Antonius P M Niessen, Paul D Pion, James A Shaw, David B Church
Current pet diabetes mellitus (DM) treatment necessitates the active daily involvement of owners and can be costly. The current study aimed to investigate the owner population which opts for euthanasia instead of DM treatment. A survey was designed using multiple feedback steps and made available online to veterinarians world-wide. A total of 1192 veterinarians completed the survey and suggested a median one in 10 diabetic pets are euthanased at diagnosis; a further median one in 10 within one year because of lack of success or compliance...
May 14, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/28944041/understanding-the-context-for-pet-cat-and-dog-feeding-and-exercising-behaviour-among-pet-owners-in-ireland-a-qualitative-study
#9
Martin J Downes, Catherine Devitt, Marie T Downes, Simon J More
BACKGROUND: Pet cat and dog obesity contributes to increased risk of several diseases, including cancer and diabetes mellitus as well as a worsening of orthopaedic problems, and a reduction in survival rate. This study aims to develop a better understanding of cat and dog owners' self-reported beliefs and factors that influence owner behaviour around feeding and exercising their pet cat or dog, as there is a lack of in-depth understanding in this area. Seven focus group discussions, with 43 pet owners in total, were conducted...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28903775/nonclinical-and-clinical-pharmacology-evidence-for-cardiovascular-safety-of-saxagliptin
#10
REVIEW
Pia S Pollack, Kristina D Chadwick, David M Smith, Martin Billger, Boaz Hirshberg, Nayyar Iqbal, David W Boulton
BACKGROUND: In the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR) trial in patients with type 2 diabetes mellitus (T2D) at high risk of cardiovascular (CV) disease, saxagliptin did not increase the risk for major CV adverse events. However, there was an unexpected imbalance in events of hospitalization for heart failure (hHF), one of six components of the secondary CV composite endpoint, with a greater number of events observed with saxagliptin...
September 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28892422/clinicopathologic-and-microbiologic-findings-associated-with-emphysematous-cystitis-in-27-dogs
#11
Lindsay Kate Merkel, Jody Lulich, David Polzin, Christopher Ober, Jodi Westropp, Jane Sykes
This is a retrospective case series of 27 dogs with emphysematous cystitis. Medical records from two veterinary teaching hospitals from 1992 to 2014 were reviewed. The aims of the study were to determine imaging findings, common underlying disease processes, and prevalent bacterial species and their antimicrobial susceptibility patterns in dogs with emphysematous cystitis. The most common lower urinary tract sign was hematuria. Gas was detected in the wall and lumen of the urinary bladder in 14 of 27 dogs (51...
November 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28863931/diabetes-mellitus-does-not-affect-the-neuromuscular-blocking-action-of-atracurium-in-dogs
#12
Elizabeth A Leece, Louise Clark
OBJECTIVE: To compare the duration of action of atracurium in diabetic and nondiabetic dogs. STUDY DESIGN: Prospective, blinded, clinical study. ANIMALS: A total of 26 diabetic and 29 nondiabetic dogs. METHODS: Following preanaesthetic medication and intravenous (IV) propofol induction, anaesthesia was maintained with isoflurane in oxygen. Atracurium 0.2 mg kg(-1) IV was administered to provide neuromuscular blockade (NMB) and the responses (twitches; T) to train-of-four nerve stimulation were recorded by palpation and electromyography (EMG)...
April 25, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28863873/evaluation-of-the-associations-between-immunoglobulin-e-levels-and-the-number-of-natural-teeth
#13
Kyungdo Han, Eunjoo Lee, Jun-Beom Park
BACKGROUND/PURPOSE: The purpose of the study was to evaluate the association between the number of natural teeth and the total serum immunoglobulin E (IgE), allergen-specific IgE against Dermatophagoides farina, allergen-specific IgE against cockroaches, or allergen-specific IgE against dogs with nationally representative data using the Korean National Health and Nutrition Examination Survey (KNHANES). METHODS: This study involved a cross-sectional analysis using KNHANES data from 2010...
August 29, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28842637/untargeted-metabolomic-analysis-in-naturally-occurring-canine-diabetes-mellitus-identifies-similarities-to-human-type-1-diabetes
#14
Allison L O'Kell, Timothy J Garrett, Clive Wasserfall, Mark A Atkinson
While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed serum metabolomic profiles of breed- and body weight-matched, diabetic (n = 6) and healthy (n = 6) dogs by liquid chromatography-mass spectrometry (LC-MS) profiling. We report distinct clustering of diabetic and control groups based on heat map analysis of known and unknown metabolites...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838299/peculiarities-of-feline-hyperadrenocorticism-update-on-diagnosis-and-treatment
#15
Lara A Boland, Vanessa R Barrs
Practical relevance: Hyperadrenocorticism (HAC) is a relatively uncommon endocrinopathy of older cats, with a mean age at diagnosis of 10 years. In addition to pituitary-dependent and adrenal-dependent hypercortisolism, clinical signs of HAC can result from adrenal sex steroid-producing tumours. Clinical challenges: While HAC in cats has many similarities to canine HAC, there are key differences in presentation, diagnosis and response to therapy. Most, but not all, cats with HAC have concurrent diabetes mellitus, which is often insulin resistant...
September 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28836097/animal-models-of-diabetic-retinopathy
#16
REVIEW
Ana Maria Olivares, Kristen Althoff, Gloria Fanghua Chen, Siqi Wu, Margaux A Morrisson, Margaret M DeAngelis, Neena Haider
PURPOSE OF REVIEW: Diabetic retinopathy (DR) is one of the most common complications associated with chronic hyperglycemia seen in patients with diabetes mellitus. While many facets of DR are still not fully understood, animal studies have contributed significantly to understanding the etiology and progression of human DR. This review provides a comprehensive discussion of the induced and genetic DR models in different species and the advantages and disadvantages of each model. RECENT FINDINGS: Rodents are the most commonly used models, though dogs develop the most similar morphological retinal lesions as those seen in humans, and pigs and zebrafish have similar vasculature and retinal structures to humans...
August 24, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28802947/canine-diabetes-mellitus-risk-factors-a-matched-case-control-study
#17
Alan Gomes Pöppl, Guilherme Luiz Carvalho de Carvalho, Itatiele Farias Vivian, Luis Gustavo Corbellini, Félix Hilário Díaz González
Different subtypes of canine diabetes mellitus (CDM) have been described based on their aetiopathogenesis. Therefore, manifold risk factors may be involved in CDM development. This study aims to investigate canine diabetes mellitus risk factors. Owners of 110 diabetic dogs and 136 healthy controls matched by breed, sex, and age were interviewed concerning aspects related to diet, weight, physical activity, oral health, reproductive history, pancreatitis, and exposure to exogenous glucocorticoids. Two multivariate multivariable statistical models were created: The UMod included males and females without variables related to oestrous cycle, while the FMod included only females with all analysed variables...
August 4, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28799185/punctate-retinal-hemorrhage-and-its-relation-to-ocular-and-systemic-disease-in-dogs-83-cases
#18
Nathaniel P Violette, Eric C Ledbetter
OBJECTIVE: To describe clinical aspects of dogs with punctate retinal hemorrhage (PRH). ANIMALS STUDIED: 83 dogs (119 eyes) with PRH. PROCEDURES: Medical records of dogs evaluated by the Cornell University ophthalmology service with a clinical diagnosis of PRH between 2006 and 2015 were reviewed. For this study, PRH was defined as retinal hemorrhages ≤ 1 optic disk diameter in size and dogs with other posterior segment ocular diseases were excluded...
August 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28759861/concurrent-hyperadrenocorticism-and-diabetes-mellitus-in-dogs
#19
D D Miceli, O P Pignataro, V A Castillo
Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and DM, and the risk factors involved that could contribute to the development of DM in dogs with HAC. A total of 235 dogs with HAC were studied and, according to their fasting glycemia, they were divided into three groups: <5.6mmol/L, between 5.6 and 10.08mmol/L and >10.08mmol/L. The following parameters were evaluated: age, gender, cause of HAC, body condition, glycemia, total cholesterol, triglycerides, urinary cortisol:creatinin ratio (UCCR) and survival time...
July 25, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28467694/durable-control-of-autoimmune-diabetes-in-mice-achieved-by-intraperitoneal-transplantation-of-neo-islets-three-dimensional-aggregates-of-allogeneic-islet-and-mesenchymal-stem-cells
#20
Christof Westenfelder, Anna Gooch, Zhuma Hu, Jon Ahlstrom, Ping Zhang
Novel interventions that reestablish endogenous insulin secretion and thereby halt progressive end-organ damage and prolong survival of patients with autoimmune Type 1 diabetes mellitus (T1DM) are urgently needed. While this is currently accomplished with allogeneic pancreas or islet transplants, their utility is significantly limited by both the scarcity of organ donors and life-long need for often-toxic antirejection drugs. Coadministering islets with bone marrow-derived mesenchymal stem cells (MSCs) that exert robust immune-modulating, anti-inflammatory, anti-apoptotic, and angiogenic actions, improves intrahepatic islet survival and function...
July 2017: Stem Cells Translational Medicine
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