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https://www.readbyqxmd.com/read/29161421/europe-pmc-in-2017
#1
Maria Levchenko, Yuci Gou, Florian Graef, Audrey Hamelers, Zhan Huang, Michele Ide-Smith, Anusha Iyer, Oliver Kilian, Jyothi Katuri, Jee-Hyub Kim, Nikos Marinos, Rakesh Nambiar, Michael Parkin, Xingjun Pi, Frances Rogers, Francesco Talo, Vid Vartak, Aravind Venkatesan, Johanna McEntyre
Europe PMC (https://europepmc.org) is a comprehensive resource of biomedical research publications that offers advanced tools for search, retrieval, and interaction with the scientific literature. This article outlines new developments since 2014. In addition to delivering the core database and services, Europe PMC focuses on three areas of development: individual user services, data integration, and infrastructure to support text and data mining. Europe PMC now provides user accounts to save search queries and claim publications to ORCIDs, as well as open access profiles for authors based on public ORCID records...
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29151971/the-predictive-and-prognostic-role-of-stromal-tumor-infiltrating-lymphocytes-in-her2-positive-breast-cancer-with-trastuzumab-based-treatment-a-meta-analysis-and-systematic-review
#2
Tao Xu, Bang-Shun He, Xiang-Xiang Liu, Xiu-Xiu Hu, Kang Lin, Yu-Qin Pan, Hui-Ling Sun, Hong-Xin Peng, Xiao-Xiang Chen, Shu-Kui Wang
Background Tumor-infiltrating lymphocytes (TILs) are white blood cells that have left the bloodstream and migrated into a tumor, involving in the prognosis of breast cancer (BC) patients. Published studies reported the value of TILs in patients with HER2-positive receiving trastuzumab-based treatment. However, the results obtained remain controversial. Here, we conducted this study to explore the predictive and prognostic role of TILs for HER2-positive BC patients receiving trastuzumab therapies. Method To identify the related published studies, a comprehensive literature search dating up to July 2017 was performed in the databases of PubMed, PMC, Web of Science and China National Knowledge Infrastructure (CNKI) according to predefined selection criteria...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151080/changes-in-u937-cell-viability-induced-by-stress-factors-possible-role-of-calmodulin
#3
K K Wojcik-Piotrowicz, J Kaszuba-Zwoinska, E Rokita, B Nowak, P Thor
Current studies were aimed to elucidate influence of magnetic field (MF) stimulation on cell viability and its effect on expression of calmodulin (CaM) and Hsp70 protein which plays a role of cell stress indicator and is a Ca(2+)-dependent CaM-binding protein. For the experimental model we have chosen U937 cell line exposed to chemical- and/or physical stress factors. Puromycin (PMC) was used as a chemical apoptosis inducer. Alternating (AC) (6.5rms mT, 35 Hz) magnetic field combined with 6 mT static (DC) component, or pulsed electromagnetic field (45 ± 5)mT, 50 Hz (PEMF) acted as physical stressors...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29144877/role-of-proteolytic-enzyme-inhibitors-on-carious-and-eroded-dentin-associated-with-a-universal-bonding-system
#4
M C Giacomini, Pmc Scaffa, L P Chaves, Cmp Vidal, T N Machado, H M Honório, L Tjäderhane, L Wang
OBJECTIVES: The aim of this study was to evaluate the effect of proteolytic inhibitors on the bond strength of a universal adhesive system (etch-and-rinse mode) applied to artificial carious and eroded dentin. METHODS: Ninety molars were prepared and randomly divided into three groups according to the substrate: N, no challenges; ACD, artificial carious dentin simulation and ERO, artificial erosion simulation with orange juice. All groups were redivided into three subgroups according to the dentin pretreatment: W, water; CHX, 2% digluconate chlorhexidine; and E-64 (trans-epoxysuccinyl-L-leucylamido-[4-guanidino] butane), 5 μM E-64 inhibitor...
November 2017: Operative Dentistry
https://www.readbyqxmd.com/read/29136133/representations-of-fine-digit-movements-in-posterior-and-anterior-parietal-cortex-revealed-using-long-train-intracortical-microstimulation-in-macaque-monkeys
#5
Mary K L Baldwin, Dylan F Cooke, Adam B Goldring, Leah Krubitzer
The current investigation in macaque monkeys utilized long-train intracortical microstimulation to determine the extent of cortex from which movements could be evoked. Not only were movements evoked from motor areas (PMC and M1), but they were also evoked from posterior parietal (5, 7a, 7b) and anterior parietal areas (3b, 1, 2). Large representations of digit movements involving only the index finger (D2) and thumb (D1), were elicited from areas 1, 2, 7b, and M1. Other movements evoked from these regions were similar to ethologically relevant movements that have been described in other primates...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29121969/microglial-dynamics-after-axotomy-induced-retinal-ganglion-cell-death
#6
Francisco M Nadal-Nicolás, Manuel Jiménez-López, Manuel Salinas-Navarro, Paloma Sobrado-Calvo, Manuel Vidal-Sanz, Marta Agudo-Barriuso
BACKGROUND: Microglial cells (MCs) are the sentries of the central nervous system. In health, they are known as surveying MCs because they examine the tissue to maintain the homeostasis. In disease, they activate and, among other functions, become phagocytic to clean the cellular debris. In this work, we have studied the behavior of rat retinal MCs in two models of unilateral complete intraorbital optic nerve axotomy which elicit a different time course of retinal ganglion cell (RGC) loss...
November 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29107090/inhibition-of-angiotensin-ii-and-calpain-attenuates-pleural-fibrosis
#7
Lin-Jie Song, Fei Xiang, Hong Ye, Hai Huang, Jie Yang, Fan Yu, Liang Xiong, Juan-Juan Xu, Peter A Greer, Huan-Zhong Shi, Jian-Bao Xin, Yunchao Su, Wan-Li Ma
Pleural fibrosis is associated with various inflammatory processes such as tuberculous pleurisy and bacterial empyema. There is currently no ideal therapeutic to attenuate pleural fibrosis. Some pro-fibrogenic mediators induce fibrosis through inflammatory processes, suggesting that blockage of these mediators might prevent pleural fibrosis. The MeT-5A human pleural mesothelial cell line (PMC) was used in this study as an in vitro model of fibrosis; and intra-pleural injection of bleomycin with carbon particles was used as an in vivo mouse model of pleural fibrosis...
October 26, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29101820/extending-the-limits-of-force-endurance-stimulation-of-the-motor-or-the-frontal-cortex
#8
Rémi Radel, Gavin Tempest, Gauthier Denis, Pierre Besson, Raphael Zory
Previous findings indicate that facilitation of primary motor cortex (PMC) activity using trans-cranial direct current stimulation (tDCS) could improve resistance to physical fatigue. However, studies have failed to consistently replicate these results. Using non-focal-tDCS during a fatiguing task, recent work showed no enhancement of corticospinal excitability of the PMC despite a longer endurance time and suggested that contamination in other brain regions involved in motor command may have occurred. In accordance with recent evidence supporting the role of the prefrontal cortex (PFC) in exercise maintenance, this double-blind sham-controlled crossover study (N = 22) compared the effect of high definition (HD)-tDCS of the PMC or the PFC on endurance time of a sustained contraction task of the elbow flexor...
October 9, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29096939/familial-colorectal-cancer-type-x-fcctx-and-the-correlation-with-various-genes-a-systematic-review
#9
REVIEW
Mahdieh Nejadtaghi, Hamideh Jafari, Effat Farrokhi, Keihan Ghatreh Samani
Familial Colorectal Cancer Type X (FCCTX) is a type of hereditary nonpolyposis colorectal cancer in accordance to Amsterdam criteria-1 for Lynch syndrome, with no related mutation in mismatch repair gene. FCCTX is microsatellite stable and is accounted for 40% of families with Amsterdam criteria-1 with a high age of onset. Thus, the carcinogenesis of FCCTX is different compared to Lynch syndrome. In addition to the microsatellite stability and the presence of less predominant tumors in proximal colon, various clinical features have also been associated with FCCTX in comparison with Lynch syndrome such as no increased risk of extra-colonic cancers, older age of diagnosis and higher adenoma/carcinoma rate...
October 18, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29093641/spatiotemporal-analysis-of-tropical-disease-research-combining-europe-pmc-and-affiliation-mapping-web-services
#10
Magnus Palmblad, Vetle I Torvik
Background: Tropical medicine appeared as a distinct sub-discipline in the late nineteenth century, during a period of rapid European colonial expansion in Africa and Asia. After a dramatic drop after World War II, research on tropical diseases have received more attention and research funding in the twenty-first century. Methods: We used Apache Taverna to integrate Europe PMC and MapAffil web services, containing the spatiotemporal analysis workflow from a list of PubMed queries to a list of publication years and author affiliations geoparsed to latitudes and longitudes...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29093171/electroencephalographic-connectivity-measures-predict-learning-of-a-motor-sequencing-task
#11
Jennifer Wu, Franziska Knapp, Steven C Cramer, Ramesh Srinivasan
Individuals vary significantly with respect to rate and degree of improvement with motor practice. While the regions that underlie motor learning have been well described, neurophysiological factors underlying differences in response to motor practice are less well understood. The present study examined both resting state and event-related EEG coherence measures of connectivity as predictors of response to motor practice on a motor sequencing task using the dominant hand. Thirty-two healthy, young, right-handed participants underwent resting EEG prior to motor practice...
November 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29092127/iatrogenic-lutembacher-syndrome-after-percutaneous-mitral-commissurotomy
#12
Theodoros D Karamitsos, Chrysovalantou Nikolaidou, Athanasios Koutsakis, Kyriakos Anastasiadis, Charalambos Karvounis, Stavros Hadjimiltiades
Atrial septal defects (ASDs) are common immediately after percutaneous mitral commissurotomy (PMC). They are usually small, hemodynamically insignificant, and tend to decrease or disappear within 6 to 12 months. Herein, a case is described of persistent ASD in a patient with mitral valve stenosis who had undergone successful PMC three years previously. The patient had signs and symptoms of right heart failure and severe tricuspid regurgitation (TR) with borderline right ventricular systolic function on echocardiography, in addition to the ASD...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29069414/the-biostudies-database-one-stop-shop-for-all-data-supporting-a-life-sciences-study
#13
Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre
BioStudies ( www.ebi.ac.uk/biostudies ) is a new public database that organizes data from biological studies. Typically, but not exclusively, a study is associated with a publication. BioStudies offers a simple way to describe the study structure, and provides flexible data deposition tools and data access interfaces. The actual data can be stored either in BioStudies or remotely, or both. BioStudies imports supplementary data from Europe PMC, and is a resource for authors and publishers for packaging data during the manuscript preparation process...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29063570/best-paper-selection
#14
(no author information available yet)
Althoff, T, Clark K, Leskovec, J. Large-scale Analysis of Counseling Conversations: An Application of Natural Language Processing to Mental Health. Trans Assoc Comput Linguist 2016(4):463-76 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361062/ Kilicoglu, H, Demner-Fushman, D. Bio-SCoRes: A Smorgasbord Architecture for Coreference Resolution in Biomedical Text. PLoS One. 2016 Mar 2;11(3):e0148538 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148538 Morid, MA, Fiszman, M, Raja, K, Jonnalagadda, SR, Del Fiol, G...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063567/best-paper-selection
#15
(no author information available yet)
Agarwal V, Podchiyska T, Banda JM, Goel V, Leung TI, Minty EP, Sweeney TE, Gyang E, Shah NH. Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc 2016;23(6):1166-73 https://academic.oup.com/jamia/article-lookup/doi/10.1093/jamia/ocw028 Harmanci A, Gerstein M. Quantification of private information leakage from phenotype-genotype data: linking attacks. Nat Methods 2016;13(3):251-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834871/ Pfiffner PB, Pinyol I, Natter MD, Mandl KD...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063564/best-paper-selection
#16
(no author information available yet)
Chen J, Rozowsky J, Galeev TR, Harmanci A, Kitchen R, Bedford J, Abyzov A, Kong Y, Regan L, Gerstein M. A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals. Nat Commun 2016 Apr 18;7:11101 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837449/ Marbach D, Lamparter D, Quon G, Kellis M, Kutalik Z, Bergmann S. Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases. Nat Methods 2016 Apr;13(4):366-70 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967716/ Zhang D, Chen P, Zheng CH, Xia J...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063561/best-paper-selection
#17
(no author information available yet)
Daniulaityte R, Chen L, Lamy FR, Carlson RG, Thirunarayan K, Sheth A. "When 'Bad' is 'Good'": Identifying Personal Communication and Sentiment in Drug-Related Tweets. JMIR Public Health Surveill 2016 Oct 24;2(2):e162 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099500/ Freedman RA, Viswanath K, Vaz-Luis I, Keating NL. Learning from social media: utilizing advanced data extraction techniques to understand barriers to breast cancer treatment. Breast Cancer Res Treat 2016 Jul;158(2):395-405 https://www.ncbi.nlm...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063554/best-paper-selection
#18
(no author information available yet)
Lin FP, Pokorny A, Teng C, Dear R, Epstein RJ. Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach. BMC Cancer 2016 Dec 1;16(1):929 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131452/ Marco-Ruiz L, Pedrinaci C, Maldonado JA, Panziera L, Chen R, Bellika JG. Publication, discovery and interoperability of Clinical Decision Support Systems: A Linked Data approach. J Biomed Inform 2016 Aug;62:243-64 http://www.sciencedirect.com/science/article/pii/S153204641630065X?via%3Dihub McEvoy DS, Sittig DF, Hickman TT, Aaron S, Ai A, Amato M, Bauer DW, Fraser GM, Harper J, Kennemer A, Krall MA, Lehmann CU, Malhotra S, Murphy DR, O'Kelley B, Samal L, Schreiber R, Singh H, Thomas EJ, Vartian CV, Westmorland J, McCoy AB, Wright A...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063551/best-paper-selection
#19
(no author information available yet)
Arnold CW, Wallace WD, Chen S, Oh A, Abtin F, Genshaft S, Binder S, Aberle D, Enzmann D. RadPath: A web-based system for integrating and correlating radiology and pathology findings during cancer diagnosis. Acad Radiol 2016 Jan;23(1):90-100 http://escholarship.org/uc/item/22x4021q Hravnak M, Chen L, Dubrawski A, Bose E, Clermont G, Pinsky MR. Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data. J Clin Monit Comput 2016 Dec;30(6):875-88 https://link...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063548/best-paper-selection
#20
(no author information available yet)
Anderson AE, Kerr WT, Thames A, Li T, Xiao J, Cohen MS. Electronic health record phenotyping improves detection and screening of type 2 diabetes in the general United States population: a crosssectional, unselected, retrospective study. J Biomed Inform 2016;60;162-8 http://www.sciencedirect.com/science/article/pii/S1532046415002865?via%3Dihub Badgeley MA, Shameer K, Glocksberg BS, Tomlinson MS, Levin MA, McCormick PJ, Kasarskis A, Reich DL, Dudley JT. EHDViz: clinical dashboard development using open-source technologies...
August 2017: Yearbook of Medical Informatics
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