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https://www.readbyqxmd.com/read/29773377/mechanically-viscoelastic-nanoreinforced-hybrid-hydrogels-composed-of-polyacrylamide-sodium-carboxymethylcellulose-graphene-oxide-and-cellulose-nanocrystals
#1
Anuj Kumar, Kummara Madhusudana Rao, Sung Soo Han
Polyacrylamide-sodium carboxymethylcellulose (PMC) hybrid hydrogels reinforced with graphene oxide (GO) and/or cellulose nanocrystals (CNCs) were prepared via in situ free-radical polymerization. In this work, GO nanosheets were freshly synthesized by modified Hummer's method alongwith the aqueous suspension of CNCs by acid-hydrolysis. In addition, the effect of GO content (1.5 wt%) and CNCs (from 2.5 wt% to 10.0 wt%) was investigated in these quaternary hydrogels. The results showed good pseudo-plastic behavior, self-healing ability, mechanical performance, and shape-recovery behavior of the hybrid hydrogels reinforced with GO and CNCs content...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29770514/influence-of-heat-treatment-on-loading-of-polymeric-multilayer-microcapsules-with-rhodamine-b
#2
Alexey V Ermakov, Olga A Inozemtseva, Dmitry A Gorin, Gleb B Sukhorukov, Sergei Belyakov, Maria N Antipina
Layer-by-layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]4 ) or poly-l-arginine/dextran sulfate ([PARG/DS]4 ) on sacrificial CaCO3 spherical microparticles are postloaded with RhB at ambient or elevated temperatures...
May 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29766507/abscisic-acid-prevents-pollen-abortion-under-high-temperature-stress-by-mediating-sugar-metabolism-in-rice-spikelets
#3
Md Rezaul Islam, Baohua Feng, Tingting Chen, Weimeng Fu, Caixia Zhang, Longxing Tao, Guanfu Fu
Heat stress at the pollen mother cell (PMC) meiotic stage leads to pollen sterility in rice, in which the reactive oxygen species (ROS) and sugar homeostasis are always adversely affected. This damage is reversed by abscisic acid (ABA), but the mechanisms underlying the interactions among the ABA, sugar metabolism, ROS and heat shock proteins (HSPs) in rice spikelets under heat stress are unclear. Two rice genotypes, Zhefu802 (a recurrent parent) and fgl (its near-isogenic line) were subjected to heat stress of 40°C after pre-foliage sprayed with ABA and its biosynthetic inhibitor fluridone at the meiotic stage of PMC...
May 16, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29762787/litvar-a-semantic-search-engine-for-linking-genomic-variant-data-in-pubmed-and-pmc
#4
Alexis Allot, Yifan Peng, Chih-Hsuan Wei, Kyubum Lee, Lon Phan, Zhiyong Lu
The identification and interpretation of genomic variants play a key role in the diagnosis of genetic diseases and related research. These tasks increasingly rely on accessing relevant manually curated information from domain databases (e.g. SwissProt or ClinVar). However, due to the sheer volume of medical literature and high cost of expert curation, curated variant information in existing databases are often incomplete and out-of-date. In addition, the same genetic variant can be mentioned in publications with various names (e...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29742502/sulfotanshinone-iia-sodium-ameliorates-glucose-peritoneal-dialysis-solution-induced-human-peritoneal-mesothelial-cell-injury-via-suppression-of-ask1-p38-mediated-oxidative-stress
#5
Yao Zhou, Weiming He, Wei Sun, Zhanwei Zhou, Minjie Sun, Ping Xia, Wei Li, Min Zheng, Lu Zhang, Jie Ni, Kun Gao
BACKGROUND/AIMS: Long-term use of high-glucose peritoneal dialysis solution (PDS) induces peritoneal mesothelial cell (PMC) injury, peritoneal dysfunction, and peritoneal dialysis (PD) failure in patients with end-stage renal disease. How to preserve PMCs in PD is a major challenge for nephrologists worldwide. In this study, we aimed to elucidate the efficacy and mechanisms of sulfotanshinone IIA sodium (Tan IIa) in ameliorating high-glucose PDS-induced human PMC injury. METHODS: The human PMC line HMrSV5 was incubated with 4...
May 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29733366/the-use-of-the-patient-assessment-of-chronic-illness-care-pacic-instrument-in-diabetes-care-a-systematic-review-and-meta-analysis
#6
Chantal Arditi, Katia Iglesias, Isabelle Peytremann-Bridevaux
Purpose: The Patient Assessment of Chronic Illness Care (PACIC) was created to assess whether provided care is congruent with the Chronic Care Model, according to patients. We aimed to identify all studies using the PACIC in diabetic patients to explore (i) how overall PACIC scores varied across studies and (ii) whether scores varied according to healthcare delivery, patient and instrument characteristics. Data sources: MEDLINE, Embase, PsycINFO, CINAHL and PubMed Central (PMC), from 2005 to 2016...
May 4, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29732277/health-state-utilities-among-contemporary-prostate-cancer-patients-on-active-surveillance
#7
Stacy Loeb, Caitlin Curnyn, Dawn Walter, Angela Fagerlin, Uwe Siebert, Nick Mühlberger, R Scott Braithwaite, Mark D Schwartz, Herbert Lepor, Erica Sedlander
Background: Active surveillance (AS) is the most rapidly expanding management option for favorable-risk prostate cancer (PCa). Early studies suggested substantial decrements in utility (quality of life weights) from disease-related anxiety. Our objective was to determine utilities for contemporary AS patients using different instruments. Methods: We performed a systematic review of PubMed, PMC and OVID for utility measurements in modern AS patients. We then examined utilities among 37 men on AS participating in focus groups between 2015-2016 using the generic EurQol five dimensions questionnaire (EQ-5D-3L) and Patient Oriented Prostate Utility Scale (PORPUS), a PCa-specific instrument...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29716986/credentialing-individual-samples-for-proteogenomic-analysis
#8
Wei Zhao, Jun Li, Rehan Akbani, Han Liang, Gordon B Mills
An integrated analysis of DNA, RNA and protein, so called proteogenomic studies, has the potential to greatly increase our understanding of both normal physiology and disease development. However, such studies are challenged by a lack of a systematic approach to credential individual samples resulting in the introduction of noise into the system that limits the ability to identify important biological signals. Indeed, a recent proteogenomic CPTAC study identified 26% of samples as unsatisfactory, resulting in a marked increase in cost and loss of information content...
May 1, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29715565/in-vivo-and-in-vitro-activity-of-a-bis-arylidenecyclo-alkanone-against-fluconazole-susceptible-and-resistant-isolates-of-candida-albicans
#9
Nívea Pereira de Sá, Lídia Fátima José de Paula, Larissa Ferreira Finamore Lopes, Lana Ivone Barreto Cruz, Thelma Tirone Silvério Matos, Cleudiomar Inácio Lino, Renata Barbosa de Oliveira, Elaine Maria de Souza-Fagundes, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Susana Johann
OBJECTIVES: Candida albicans is a commensal pathogen associated with both superficial (mucosal and cutaneous) and systemic infections. The extensive use of antifungal agents has led to reduced susceptibility to the few existing drugs. This situation has encouraged the search for novel antifungal agents. Therefore, in the present study, we investigated the antifungal activity of 2,6-bis[(E)-(4-pyridyl)methylidene]cyclohexanone (PMC). METHODS: We evaluated its in vitro activity against C...
April 28, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29682575/the-role-of-tympanic-membrane-retractions-in-cholesteatoma-pathogenesis
#10
Letícia Petersen Schmidt Rosito, Neil Sperling, Adriane Ribeiro Teixeira, Fábio André Selaimen, Sady Selaimen da Costa
Objective: To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE. Methods: Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29676793/massively-parallel-approximate-bayesian-computation-for-estimating-nanoparticle-diffusion-coefficients-sizes-and-concentrations-using-confocal-laser-scanning-microscopy
#11
M Röding, M Billeter
We implement a massively parallel population Monte Carlo approximate Bayesian computation (PMC-ABC) method for estimating diffusion coefficients, sizes and concentrations of diffusing nanoparticles in liquid suspension using confocal laser scanning microscopy and particle tracking. The method is based on the joint probability distribution of diffusion coefficients and the time spent by a particle inside a detection region where particles are tracked. We present freely available central processing unit (CPU) and graphics processing unit (GPU) versions of the analysis software, and we apply the method to characterize mono- and bidisperse samples of fluorescent polystyrene beads...
April 20, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29667200/treatment-in-a-preventive-cardiology-clinic-utilizing-advanced-practice-providers-apps-effectively-closes-atherosclerotic-cardiovascular-disease-ascvd-risk-management-gaps-amongst-a-primary-prevention-population-compared-with-a-propensity-matched-primary-care
#12
Emilio Fentanes, Anthony G Vande Hei, R Scott Holuby, Norma Suarez, Yousif Slim, Jennifer N Slim, Ahmad M Slim, Dustin Thomas
BACKGROUND: Advanced Practice Providers (APPs) can fill access to care gaps created by physician shortages and improve adherence/compliance with preventive atherosclerotic cardiovascular disease (ASCVD) interventions. METHODS: We retrospectively reviewed data on 595 patients enrolled in a preventive cardiology clinic (PCC) utilizing APPs compared with a propensity-matched cohort (PMC) of 595 patients enrolled in primary care clinics alone. PCC patients were risk stratified using Framingham risk scoring (FRS) and coronary artery calcium scoring (CACS) and treated based on published guideline-based algorithms...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29666262/spatial-and-temporal-heterogeneity-of-neural-responses-in-human-posteromedial-cortex
#13
Amy L Daitch, Josef Parvizi
Neuroimaging evidence supports a role of the default mode network (DMN) in spontaneous thought and goal-driven internally oriented processes, such as recalling an autobiographical event, and has demonstrated its deactivation during focused, externally oriented attention. Recent work suggests that the DMN is not a homogeneous network but rather is composed of at least several subnetworks, which are engaged in distinct functions; however, it is still unclear if these different functions rely on the same neuronal populations...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29663912/periodontal-impact-of-preformed-metal-crowns-on-permanent-molars-of-children-and-adolescents-a-pilot-study
#14
Aikaterini Koleventi, Dimitra Sakellari, Konstantinos N Arapostathis, Nikolaos Kotsanos
PURPOSE: When treating an early permanent molar with coronal malformation in children, as in severe molar incisor hypomineralization (MIH) cases, preformed metal crowns (PMCs) are a successful mid- to long-term restorative option. The purpose of this study was to evaluate possible changes in periodontal tissues and subgingival microbiota after PMC placement by way of a split-mouth study. METHODS: Fourteen healthy patients with a mean age of 10.6 (±4.2) years old, attending a university dental clinic, had one MIH severely affected permanent first molar restored with a PMC (study side), while the contralateral relatively healthy tooth was the control...
March 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29661724/variation-in-nuclear-size-and-pd-l2-positivity-correlate-with-aggressive-chromophobe-renal-cell-carcinoma
#15
Mohamed E Mostafa, Amrou Abdelkader, Naoto Kuroda, Delia Pérez-Montiel, Anjishnu Banerjee, Ondrej Hes, Kenneth A Iczkowski
Chromophobe renal cell carcinoma (CRCC) is not amenable to International Society for Urologic Pathology-endorsed nucleolar grading. Novel grading approaches were proposed, but the rarity of adverse pathology hampers their discriminatory value. We investigate simple linear micrometer measurements and a proposed immunostain in CRCCs. 32 patients' CRCCs were studied: 12 adverse cases (stage pT3, recurrence, or metastasis), 15 controls (stage ≤pT2, no recurrence or metastasis after >3 years), and 8 metastases (3 were paired with primary adverse cases)...
January 10, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29658554/a-sinter-resistant-catalyst-using-an-alumina-support-recycled-from-alp-fumigation-residue-trash-to-treasure
#16
Jinshi Dong, Jun Wang, Jianqiang Wang, Guanghao Cheng, Tianming Huang, Meiqing Shen
Sintering is a long-standing issue especially in high temperature catalytic applications. In this paper, we report an effective method to slow down metal particle migration and coalescence (PMC) by using a thermally stable alumina support. Noteworthily, the alumina sample was developed from AlP fumigation residue, which is a very dangerous substance for living creatures and environment protection. By optimizing the heated hydrolysis and ball-milling conditions, we recycled a phosphate-stabilized alumina material that retained a 117 m2 g-1 surface area after 1050 °C hydrothermal aging...
April 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29653280/the-beneficial-effect-of-a-speaker-s-gestures-on-the-listener-s-memory-for-action-phrases-the-pivotal-role-of-the-listener-s-premotor-cortex
#17
Francesco Ianì, Dalila Burin, Adriana Salatino, Lorenzo Pia, Raffaella Ricci, Monica Bucciarelli
Memory for action phrases improves in the listeners when the speaker accompanies them with gestures compared to when the speaker stays still. Since behavioral studies revealed a pivotal role of the listeners' motor system, we aimed to disentangle the role of primary motor and premotor cortices. Participants had to recall phrases uttered by a speaker in two conditions: in the gesture condition, the speaker performed gestures congruent with the action; in the no-gesture condition, the speaker stayed still. In Experiment 1, half of the participants underwent inhibitory rTMS over the hand/arm region of the left premotor cortex (PMC) and the other half over the hand/arm region of the left primary motor cortex (M1)...
April 10, 2018: Brain and Language
https://www.readbyqxmd.com/read/29625493/characterization-of-a-spontaneously-immortalized-murine-m%C3%A3-ller-glial-cell-line-qmmuc-1
#18
Josy Augustine, Sofia Pavlou, Michael O'Hare, Kevin Harkin, Alan Stitt, Tim Curtis, Heping Xu, Mei Chen
Purpose: Müller glia are critical for the survival of retinal neurons and the integrity of retinal blood vessels. Müller glial cultures are important tools for investigating Müller glial pathophysiology. Here, we report a spontaneously immortalized Müller glial cell line originally cultured and subsequently cloned from mouse pups. The cell line, Queen's University Murine Müller glia Clone-1 (QMMuC-1), has been cultured for over 60 passages, has morphologic features like primary Müller cell (PMC) cultures and remains stable...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29614707/best-core-stabilization-exercise-to-facilitate-subcortical-neuroplasticity-a-functional-mri-neuroimaging-study
#19
Do Hyun Kim, Jae Jin Lee, Sung Joshua Hyun You
OBJECTIVE: To investigate the effects of conscious (ADIM) and subconscious (DNS) core stabilization exercises on cortical changes in adults with core instability. PARTICIPANTS: Five non-symptomatic participants with core instability. METHODS: A novel core stabilization task switching paradigm was designed to separate cortical or subcortical neural substrates during a series of DNS or ADIM core stabilization tasks. RESULTS: fMRI blood BOLD analysis revealed a distinctive subcortical activation pattern during the performance of the DNS, whereas the cortical motor network was primarily activated during an ADIM...
March 23, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29608416/trends-in-the-implementation-of-active-surveillance-for-low-risk-papillary-thyroid-microcarcinomas-at-kuma-hospital-gradual-increase-and-heterogeneity-in-the-acceptance-of-this-new-management-option
#20
Yasuhiro Ito, Akira Miyauchi, Takumi Kudo, Hitomi Oda, Masatoshi Yamamoto, Hisanori Sasai, Hiroo Masuoka, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Akihiro Miya
BACKGROUND: Active surveillance (AS) of low-risk papillary thyroid microcarcinoma (PMC) was adopted as a management modality in both the Japanese guidelines in 2011 and the American Thyroid Association guidelines in 2015. AS was initiated at Kuma Hospital in 1993 but was not immediately accepted by all physicians. This study investigated the history of acceptance of AS at Kuma Hospital over time. The results should assist in the implementation of AS at other hospitals in Japan and other countries...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
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