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https://www.readbyqxmd.com/read/28205500/primary-motor-cortex-excitability-is-modulated-during-the-mental-simulation-of-hand-movement
#1
Christian Hyde, Ian Fuelscher, Jarrad A G Lum, Jacqueline Williams, Jason He, Peter G Enticott
OBJECTIVES: It is unclear whether the primary motor cortex (PMC) is involved in the mental simulation of movement [i.e., motor imagery (MI)]. The present study aimed to clarify PMC involvement using a highly novel adaptation of the hand laterality task (HLT). METHODS: Participants were administered single-pulse transcranial magnetic stimulation (TMS) to the hand area of the left PMC (hPMC) at either 50 ms, 400 ms, or 650 ms post stimulus presentation. Motor-evoked potentials (MEPs) were recorded from the right first dorsal interosseous via electromyography...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28194660/a-novel-apparatus-for-the-multifaceted-evaluation-of-arterial-function-through-transmural-pressure-manipulation
#2
Toshiyuki Yaguchi, Yalin Cong, Kenji Shimo, Takahiro Kurokawa, Shukei Sugita, Kazuaki Nagayama, Hiroshi Masuda, Takeo Matsumoto
A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC)...
February 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28194530/application-of-selected-scaffolds-for-bone-tissue-engineering-a-systematic-review
#3
REVIEW
Sepanta Hosseinpour, Mitra Ghazizadeh Ahsaie, Maryam Rezai Rad, Mohammad Taghi Baghani, Saeed Reza Motamedian, Arash Khojasteh
PURPOSE: The current systematic review investigated the results of application of some of the most commonly used scaffolds in conjugation with stem cells and growth factors in animal and clinical studies. METHODS: A comprehensive electronic search was conducted according to the PRISMA guidelines in NCBI PMC and PubMed from January 1970 to December 2015 limited to English language publications with available full texts. In vivo studies in relation to "bone healing," "bone regeneration," and at least one of the following items were investigated: allograft, β-tricalcium phosphate, deproteinized bovine bone mineral, hydroxyapetite/tricalcium phosphate, nanohydroxyapatite, and composite scaffolds...
February 13, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28188999/the-small-gtpase-arf6-regulates-sea-urchin-morphogenesis
#4
Nadezda A Stepicheva, Megan Dumas, Priscilla Kobi, Julie G Donaldson, Jia L Song
The small GTPase Arf6 is a conserved protein that is expressed in all metazoans. Arf6 remodels cytoskeletal actin and mediates membrane protein trafficking between the plasma membrane in its active form and endosomal compartments in its inactive form. While a rich knowledge exists for the cellular functions of Arf6, relatively little is known about its physiological role in development. This study examines the function of Arf6 in mediating cellular morphogenesis in early development. We dissect the function of Arf6 with a loss-of-function morpholino and constitutively active Arf6-Q67L construct...
February 2, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28188896/alteration-of-neurotransmission-and-skeletogenesis-in-sea-urchin-arbacia-lixula-embryos-exposed-to-copper-oxide-nanoparticles
#5
Tiziana Cappello, Valeria Vitale, Sabrina Oliva, Valentina Villari, Angela Mauceri, Salvatore Fasulo, Maria Maisano
The extensive use of copper oxide nanoparticles (CuO NPs) in many applications has raised concerns over their toxicity on environment and human health. Herein, the embryotoxicity of CuO NPs was assessed in the black sea urchin Arbacia lixula, an intertidal species commonly present in the Mediterranean. Fertilized eggs were exposed to 0.7, 10 and 20ppb of CuO NPs, until pluteus stage. Interferences with the normal neurotransmission pathways were observed in sea urchin embryos. In detail, evidence of cholinergic and serotoninergic systems affection was revealed by dose-dependent decreased levels of choline and N-acetyl serotonin, respectively, measured by nuclear magnetic resonance (NMR)-based metabolomics, applied for the first time to our knowledge on sea urchin embryos...
February 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28177834/cytogenetic-study-and-stripe-rust-response-of-the-derivatives-from-a-wheat-thinopyrum-intermedium-psathyrostachys-huashanica-trigeneric-hybrid
#6
Kang Houyang, Lin Tang, Daiyan Li, Chengdou Diao, Wei Zhu, Yao Tang, Yi Wang, Xing Fan, Lili Xu, Jian Zeng, Sha Lina, Xiaofang Yu, Zhang Haiqin, Yong-Hong Zhou
In this work, the meiotic behavior, chromosome constitution, and stripe rust resistance of the F5 derivatives from wheat-Th. intermedium-P. huashanica trigeneric hybrid were studied. Cytological analysis indicated that the chromosome number of F5 progenies ranged from 42 to 50. The mean meiotic configuration of F5 lines was 1.28 univalents, 21.74 bivalents, 0.04 trivalents, and 0.02 tetravalents per pollen mother cell (PMC). Among the lines with 2n = 42, the average pairing configuration was 0.05 I + 19.91 II (ring) + 1...
December 10, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28162895/the-brain-basis-for-misophonia
#7
Sukhbinder Kumar, Olana Tansley-Hancock, William Sedley, Joel S Winston, Martina F Callaghan, Micah Allen, Thomas E Cope, Phillip E Gander, Doris-Eva Bamiou, Timothy D Griffiths
Misophonia is an affective sound-processing disorder characterized by the experience of strong negative emotions (anger and anxiety) in response to everyday sounds, such as those generated by other people eating, drinking, chewing, and breathing [1-8]. The commonplace nature of these sounds (often referred to as "trigger sounds") makes misophonia a devastating disorder for sufferers and their families, and yet nothing is known about the underlying mechanism. Using functional and structural MRI coupled with physiological measurements, we demonstrate that misophonic subjects show specific trigger-sound-related responses in brain and body...
February 1, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28160587/use-of-self-organizing-maps-for-analyzing-the-behavior-of-canines-displaced-towards-midline-under-interceptive-treatment
#8
V Gandía-Aguiló, R Cibrián, E Soria, A-J Serrano, L Aguiló, V Paredes, J-L Gandía
BACKGROUND: Displaced maxillary permanent canine is one of the more frequent findings in canine eruption process and it's easy to be outlined and early diagnosed by means of x-ray images. Late diagnosis frequently needs surgery to rescue the impacted permanent canine. In many cases, interceptive treatment to redirect canine eruption is needed. However, some patients treated by interceptive means end up requiring fenestration to orthodontically guide the canine to its normal occlusal position...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28160058/the-utility-of-the-bethesda-category-and-its-association-with-braf-mutation-in-the-prediction-of-papillary-thyroid-cancer-stage
#9
Augustas Beiša, Mindaugas Kvietkauskas, Virgilijus Beiša, Mindaugas Stoškus, Elvyra Ostanevičiūtė, Eugenijus Jasiūnas, Laimonas Griškevičius, Kęstutis Strupas
PURPOSE: This study aims to determine the utility of the Bethesda category and its association with BRAF mutation in prediction of the papillary thyroid cancer (PTC) stage. METHODS: A prospective study analyzed patients who had ultrasound-suspicious thyroid nodules, underwent FNA and cytological examination, and were classified according to the Bethesda system. Patients from Undetermined Significance Or Follicular Lesion Of Undetermined Significance (AUS/FLUS), Follicular Neoplasm or Suspicious for a Follicular Neoplasm (FN/SFN), Suspicious for Malignant Cells (SMC), and Positive for Malignant Cells (PMC) groups were examined for the BRAF mutation and had a thyroid surgery...
February 3, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28154971/the-sensorimotor-network-dysfunction-in-migraineurs-without-aura-a-resting-state-fmri-study
#10
Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qi-Ting Zhang, Qian Yao, Haifeng Lu, Hui Zhang, Ge-Fei Li, Yi-Lan Wu, Yi-Sheng Liu, Feng-Di Liu, Mei-Ting Zhuang, Yan-Hui Shi, Tian-Yu Hou, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
Migraine is a common recurrent neurological disorder combining nausea, vomiting, and hypersensitivities to visual, auditory, olfactory and somatosensory stimuli. However, the dysfunction of the sensorimotor network in migraineurs has not been well clarified. In the present study, we evaluated the dysfunction of the sensorimotor network in 30 migraineurs without aura and in 31 controls by combining regional homogeneity (ReHo), amplitudes of low-frequency fluctuation (ALFF) and degree centrality (DC) analysis methods based on resting-state fMRI...
February 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28141913/systemic-corticosteroid-regimens-for-prevention-of-bronchopulmonary-dysplasia-in-preterm-infants
#11
REVIEW
Wes Onland, Anne Pmc De Jaegere, Martin Offringa, Anton van Kaam
BACKGROUND: Cochrane systematic reviews show that systemic postnatal corticosteroids reduce the risk of bronchopulmonary dysplasia (BPD) in preterm infants. However, corticosteroids have also been associated with an increased risk of neurodevelopmental impairment. It is unknown whether these beneficial and adverse effects are modulated by differences in corticosteroid treatment regimens. OBJECTIVES: To assess the effects of different corticosteroid treatment regimens on mortality, pulmonary morbidity, and neurodevelopmental outcome in very low birth weight (VLBW) infants...
January 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28131417/mir-18a-5p-inhibits-sub-pleural-pulmonary-fibrosis-by-targeting-tgf-%C3%AE-receptor-ii
#12
Qian Zhang, Hong Ye, Fei Xiang, Lin-Jie Song, Li-Ling Zhou, Peng-Cheng Cai, Jian-Chu Zhang, Fan Yu, Huan-Zhong Shi, Yunchao Su, Jian-Bao Xin, Wan-Li Ma
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease that typically leads to respiratory failure and death within 3-5 years of diagnosis. Sub-pleural pulmonary fibrosis is a pathological hallmark of IPF. Bleomycin treatment of mice is a an established pulmonary fibrosis model. We recently showed that bleomycin-induced epithelial-mesenchymal transition (EMT) contributes to pleural mesothelial cell (PMC) migration and sub-pleural pulmonary fibrosis. MicroRNA (miRNA) expression has recently been implicated in the pathogenesis of IPF...
January 25, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28124394/treatment-decision-making-in-early-stage-papillary-thyroid-cancer
#13
Thomas A D'Agostino, Elyse Shuk, Erin K Maloney, Rebecca Zeuren, R Michael Tuttle, Carma L Bylund
OBJECTIVE: The purpose of this study was to develop an in-depth understanding of papillary microcarcinoma (PMC) patients' decision-making process when offered options of surgery and active surveillance. METHODS: 15 PMC patients and six caregivers participated in either a focus group or individual interview. Focus groups were segmented by patients' treatment choice. Primary themes were identified in transcripts using thematic text analysis. RESULTS: Four themes emerged from the surgery subsample: (1) Decision to undergo thyroidectomy quickly and with a sense of urgency; (2) Perception of PMC as a potentially life-threatening disease; (3) Fear of disease progression and unremitting uncertainty with active surveillance; and (4) Surgery as a means of control and potential cure...
January 26, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28104088/myocardial-wall-thinning-predicts-transmural-substrate-in-patients-with-scar-related-ventricular-tachycardia
#14
Seigo Yamashita, Frédéric Sacher, Darren A Hooks, Benjamin Berte, Jean-Marc Sellal, Antonio Frontera, Nora Al Jefairi, Yuki Komatsu, Sana Amraoui, Arnaud Denis, Nicolas Derval, Maxime Sermesant, François Laurent, Michel Montaudon, Mélèze Hocini, Michel Haïssaguerre, Pierre Jaïs, Hubert Cochet
BACKGROUND: Scar-related ventricular tachycardia (VT) arises from specific substrate according to etiology. OBJECTIVE: The purpose of this study was to evaluate the relationship between wall thinning (WT) on multidetector computed tomography (MDCT) and local abnormal ventricular activity (LAVA) in patients with ischemic cardiomyopathy (ICM), postmyocarditis (PMC), and dilated cardiomyopathy (DCM). METHODS: Forty-two patients (40 male, age 58 ± 13 years, 22 ICM, 11 PMC, 9 DCM) underwent MDCT before a combined endo-/epicardial VT ablation procedure...
February 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28100728/direct-cortical-stimulation-of-human-posteromedial-cortex
#15
Brett L Foster, Josef Parvizi
BACKGROUND: The posteromedial cortex (PMC) is a collective term for an anatomically heterogeneous area of the brain constituting a core node of the human default mode network (DMN), which is engaged during internally focused subjective cognition such as autobiographical memory. METHODS: We explored the effects of causal perturbations of PMC with direct electric brain stimulation (EBS) during presurgical epilepsy monitoring with intracranial EEG electrodes. RESULTS: Data were collected from 885 stimulations in 25 patients implanted with intracranial electrodes across the PMC...
January 18, 2017: Neurology
https://www.readbyqxmd.com/read/28050444/review-of-the-management-of-peroral-extrusion-of-ventriculoperitoneal-shunt-catheter
#16
REVIEW
Rajendra Kumar Ghritlaharey
INTRODUCTION: Peroral extrusion of peritoneal part of Ventriculoperitoneal Shunt (VPS) catheter is an extremely rare complication following VPS implantation. AIM: To review the options available for the management of peroral extrusion of VPS catheter. MATERIALS AND METHODS: PubMed, Medline, PMC (PubMed Central), Embase, Google scholar databases search was performed to retrieve the published/available data relating to the peroral extrusion of VPS catheter...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28041838/ambient-fine-and-coarse-particulate-matter-pollution-and-respiratory-morbidity-in-dongguan-china
#17
Yiju Zhao, Shengyong Wang, Lingling Lang, Caiyan Huang, Wenjun Ma, Hualiang Lin
We estimated the short-term effects of particulate matter (PM) pollution with aerodynamic diameters ≤2.5 μm (PM2.5) and between 2.5 and 10 μm (PMc) on hospital outpatient visits due to overall and specific respiratory diseases, as well as the associated morbidity burden in Dongguan, a subtropical city in South China. A time-series model with quasi-Poisson link was used to examine the association between PM pollution and morbidities from respiratory diseases, COPD, asthma and pneumonia in Dongguan during 2013-2015...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28027988/the-immune-response-of-the-c-jun-in-the-black-tiger-shrimp-penaeus-monodon-after-bacterial-infection
#18
Gongfang Shi, Chao Zhao, Mingjun Fu, Lihua Qiu
The transcription factor C-Jun widely exists in vertebrates and invertebrates and plays an important role in various kinds of stimulus response. In this study, PmC-jun gene was first cloned from Penaeus monodon. The full-length cDNA of PmC-jun was 1857 bp in length and included an 879 bp open reading frame (ORF), which encoded 293 amino acids. qRT-PCR analysis results showed that PmC-jun mRNAs were ubiquitously expressed in all the examined tissues. The highest expression level was observed in gill, followed by hepatopancreas...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28027814/outcome-of-total-hip-and-total-knee-revision-arthroplasty-with-minor-infection-criteria-a-retrospective-matched-pair-analysis
#19
Kevin Staats, Paul Kolbitsch, Irene K Sigmund, Gerhard M Hobusch, Johannes Holinka, Reinhard Windhager
BACKGROUND: Although diagnostic modalities for the detection of periprosthetic joint infection have improved, some infectious revision cases may still be diagnosed as aseptic complications. We raised the question whether patients with positive Musculoskeletal Infection Society minor infection criteria differ in their outcome parameters (revision-free survival, revision rate) when compared to patients with "true" aseptic complications. Additionally, we asked whether the indication for revision surgery (eg, loosening) might have an influence on possible outcome discrepancies...
November 19, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28009386/detection-of-giardia-intestinalis-infections-in-polish-soldiers-deployed-to-afghanistan
#20
Krzysztof Korzeniewski, Monika Konior, Alina Augustynowicz, Anna Lass, Ewa Kowalska
BACKGROUND: Members of the Polish Military Contingent (PMC) have been stationed in Afghanistan since 2002. They typically serve in areas characterised by low standards of sanitation which often leads to the development of food- and waterborne diseases. The aim of the study was to evaluate the prevalence of Giardia intestinalis infections among Polish soldiers deployed to Afghanistan. The research study was conducted as part of a programme for prevention of parasitic diseases of the gastrointestinal tract run by the Polish Armed Forces...
2016: International Maritime Health
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