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https://www.readbyqxmd.com/read/28800626/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis
#1
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (Lox) is a key enzyme required for crosslinking and deposition of insoluble collagen, so we investigated whether targeting Lox might be an approach to reduce abdominal adhesions. METHODS: Female C57Bl/6 mice were treated intraperitoneally with multiwalled carbon nanotubes (NT) to induce fibrosis, together with chemical (ß-aminoproprionitrile-BAPN) or miRNA Lox inhibitors, progesterone or dexamethasone...
2017: PloS One
https://www.readbyqxmd.com/read/28782554/endocytosis-in-primary-mesenchyme-cells-during-sea-urchin-larval-skeletogenesis
#2
Christopher E Killian, Fred H Wilt
The sea urchin larval embryo elaborates two calcitic endoskeletal elements called spicules. Spicules are synthesized by the primary mesenchyme cells (PMCs) and begin to form at early gastrula stage. It is known that the calcium comprising the spicules comes from the seawater and we wish to further consider the mode of calcium transport from the extracellular seawater to the PMCs and then onto the forming spicules. We used PMC in vitro cultures, calcein, fluorescently labeled dextran, and fluorescently labeled Wheat Germ Agglutinin (WGA) to track calcium transport from the seawater into PMCs and spicules and to determine how molecules from the surface of PMCs interact with the incoming calcium...
August 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28782512/quantitative-expression-and-localization-of-gabab-receptor-protein-subunits-in-hippocampi-from-patients-with-refractory-temporal-lobe-epilepsy
#3
REVIEW
Mariam A Sheilabi, Dev Battacharyya, Laura Caetano, Maria Thom, Markus Reuber, John S Duncan, Alessandra P Princivalle
This study investigates GABAB protein expression and mRNA levels in three types of specimens. Two types of specimens from patients with temporal lobe epilepsy (TLE), secondary to hippocampal sclerosis, sclerotic hippocampal samples (TLE-HS), and tissue from the structurally preserved non-spiking ipsilateral superior temporal gyrus (TLE-STG) removed from the same patient during epilepsy surgery; and third specimen is hippocampal tissue from individuals with no history of epilepsy (post-mortem controls, PMC)...
August 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28770254/3d-correction-of-ais-in-braces-designed-using-cad-cam-and-fem-a-randomized-controlled-trial
#4
Nikita Cobetto, Carl-Éric Aubin, Stefan Parent, Soraya Barchi, Isabelle Turgeon, Hubert Labelle
BACKGROUND: Recent studies showed that finite element model (FEM) combined to CAD/CAM improves the design of braces for the conservative treatment of adolescent idiopathic scoliosis (AIS), using 2D measurements from in-brace radiographs. We aim to assess the immediate effectiveness on curve correction in all three planes of braces designed using CAD/CAM and numerical simulation compared to braces designed with CAD/CAM only. METHODS: SRS standardized criteria for bracing were followed to recruit 48 AIS patients who were randomized into two groups...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28761810/cerebellar-degeneration-affects-cortico-cortical-connectivity-in-motor-learning-networks
#5
Elinor Tzvi, Christoph Zimmermann, Richard Bey, Thomas F Münte, Matthias Nitschke, Ulrike M Krämer
The cerebellum plays an important role in motor learning as part of a cortico-striato-cerebellar network. Patients with cerebellar degeneration typically show impairments in different aspects of motor learning, including implicit motor sequence learning. How cerebellar dysfunction affects interactions in this cortico-striato-cerebellar network is poorly understood. The present study investigated the effect of cerebellar degeneration on activity in causal interactions between cortical and subcortical regions involved in motor learning...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28758029/concern-noted-a-descriptive-study-of-editorial-expressions-of-concern-in-pubmed-and-pubmed-central
#6
Melissa Vaught, Diana C Jordan, Hilda Bastian
BACKGROUND: An editorial expression of concern (EEoC) is issued by editors or publishers to draw attention to potential problems in a publication, without itself constituting a retraction or correction. METHODS: We searched PubMed, PubMed Central (PMC), and Google Scholar to identify EEoCs issued for publications in PubMed and PMC up to 22 August 2016. We also searched the archives of the Retraction Watch blog, some journal and publisher websites, and studies of EEoCs...
2017: Research Integrity and Peer Review
https://www.readbyqxmd.com/read/28752330/cortico-thalamic-disconnection-in-a-patient-with-supernumerary-phantom-limb
#7
Clémence Bourlon, Marika Urbanski, Romain Quentin, Christophe Duret, Eric Bardinet, Paolo Bartolomeo, Alexia Bourgeois
Supernumerary phantom limb (SPL) designates the experience of an illusory additional limb occurring after brain damage. Functional neuroimaging during SPL movements documented increased response in the ipsilesional supplementary motor area (SMA), premotor cortex (PMC), thalamus and caudate. This suggested that motor circuits are important for bodily related cognition, but anatomical evidence is sparse. Here, we tested this hypothesis by studying an extremely rare patient with chronic SPL, still present 3 years after a vascular stroke affecting cortical and subcortical right-hemisphere structures...
July 27, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#8
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28747834/analysis-of-consumers-preferences-and-price-sensitivity-to-native-chickens
#9
Min-A Lee, Yoojin Jung, Cheorun Jo, Ji-Young Park, Ki-Chang Nam
This study analyzed consumers' preferences and price sensitivity to native chickens. A survey was conducted from Jan 6 to 17, 2014, and data were collected from consumers (n=500) living in Korea. Statistical analyses evaluated the consumption patterns of native chickens, preference marketing for native chicken breeds which will be newly developed, and price sensitivity measurement (PSM). Of the subjects who preferred broilers, 24.3% do not purchase native chickens because of the dryness and tough texture, while those who preferred native chickens liked their chewy texture (38...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28730295/incarceration-of-the-medial-collateral-ligament-in-the-intercondylar-notch-following-proximal-avulsion
#10
Edward Walton, Martin Williams, James R Robinson
Intra-articular entrapment of the medial collateral ligament (MCL) is a rare but recognised complication of traumatic injury to the posteromedial corner (PMC) of the knee. Considering the MCL is the most commonly injured ligament of the knee this complication is extremely rare with only a handful of cases describing MCL entrapment following distal avulsion of the MCL. We present the first known case of MCL entrapment following proximal avulsion of the MCL and posterior oblique ligament (POL) with the mid-substance of the MCL becoming entrapped in the joint, lying on the superior surface of the medial meniscus and extending up into the intercondylar notch...
July 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28713629/abducent-nerve-palsy-after-microballoon-compression-of-the-trigeminal-ganglion-case-report
#11
Cassiano Marchi, Paulo Henrique Pires de Aguiar, Ana Maria Moura, Giovanna Matricardi, Carolina Utsunomya Muniz, Rogério Aires, Flávia Gehrke, Natally Santiago, Samuel Simis
BACKGROUND: Trigeminal neuralgia (TN) is the most common type of facial neuralgia with incidence of 26.8/100,000 person year. In general, this scenario is characterized by a lancinating, unilateral, paroxysmal pain in the area of the fifth cranial nerve. Several treatment methods, including the injection of ethyl alcohol or butyl alcohol into the ganglion, the glycerol injection into the trigeminal cistern, peripheral nerve divisions, the radiofrequency thermocoagulation of the preganglionic fibers, and radiosurgery has been used for TN...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28710437/inhibition-of-ctgf-ameliorates-peritoneal-fibrosis-through-suppression-of-fibroblast-and-myofibroblast-accumulation-and-angiogenesis
#12
Norihiko Sakai, Miki Nakamura, Kenneth E Lipson, Taito Miyake, Yasutaka Kamikawa, Akihiro Sagara, Yasuyuki Shinozaki, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Shuichi Kaneko, Andrew M Tager, Takashi Wada
Peritoneal fibrosis (PF) is a serious complication in various clinical settings, but the mechanisms driving it remain to be fully determined. Connective tissue growth factor (CTGF) is known to regulate fibroblast activities. We therefore examined if CTGF inhibition has anti-fibrotic effects in PF. PF was induced by repetitive intraperitoneal injections of chlorhexidine gluconate (CG) in mice with type I pro-collagen promoter-driven green fluorescent protein (GFP) expression to identify fibroblasts. FG-3019, an anti-CTGF monoclonal antibody, was used to inhibit CTGF...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691235/outcomes-of-the-conventional-and-biological-treatment-approaches-for-the-management-of-caries-in-the-primary-dentition
#13
Alaa BaniHani, Monty Duggal, Jack Toumba, Chris Deery
BACKGROUND: In the last few years, conventional restorations including complete removal of carious tissue (CT) with or without pulp therapy for the treatment of carious lesions (CL) in primary teeth have been challenged and a more biological approach has been suggested. This approach involves the use of less invasive techniques which alter the environment of the CL isolating it from the cariogenic biofilm and substrate. Two of these treatment approaches that are becoming increasingly widely accepted and used in paediatric dentistry are the Hall Technique and indirect pulp capping (IPC)...
July 9, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28688673/characterization-of-phebe7-an-incfii-type-virulence-resistance-plasmid-carrying-blactx-m-98b-blatem-1-and-rmtb-genes-detected-in-escherichia-coli-from-a-chicken-isolate-in-china
#14
Yan-Xian Yang, Yong-Qiang Yang, Chang-Wei Lei, Bi-Hui Liu, Wei Jiang, Hong-Ning Wang, Maria Consuelo Gazitúa, An-Yun Zhang
Recently, a novel variant of the CTX-M enzyme, CTX-M-98, was detected in Escherichia coli isolates from food animals. However, few plasmids carrying blaCTX-M-98 have been fully characterized. In this study, we sequenced the complete pHeBE7 plasmid, an 86,015-bp plasmid that contains the blaCTX-M-98b, blaTEM-1, rmtB, and traT genes, using whole-genome sequencing. The backbone of pHeBE7 shows a high similarity (>99%) to pMC-NDM, which carries the blaNDM-1 gene, however its mosaic regions remain relatively unique among sequenced plasmids...
July 6, 2017: Plasmid
https://www.readbyqxmd.com/read/28673289/semantic-relatedness-and-similarity-of-biomedical-terms-examining-the-effects-of-recency-size-and-section-of-biomedical-publications-on-the-performance-of-word2vec
#15
Yongjun Zhu, Erjia Yan, Fei Wang
BACKGROUND: Understanding semantic relatedness and similarity between biomedical terms has a great impact on a variety of applications such as biomedical information retrieval, information extraction, and recommender systems. The objective of this study is to examine word2vec's ability in deriving semantic relatedness and similarity between biomedical terms from large publication data. Specifically, we focus on the effects of recency, size, and section of biomedical publication data on the performance of word2vec...
July 3, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28662448/arterial-blood-pressure-responses-to-short-term-exposure-to-fine-and-ultrafine-particles-from-indoor-sources-a-randomized-sham-controlled-exposure-study-of-healthy-volunteers
#16
Vanessa J Soppa, Roel P F Schins, Frauke Hennig, Mark J Nieuwenhuijsen, Bryan Hellack, Ulrich Quass, Heinz Kaminski, Birgitta Sasse, Samir Shinnawi, Thomas A J Kuhlbusch, Barbara Hoffmann
OBJECTIVES: Particulate air pollution is linked to adverse cardiovascular effects. The aim of the study was to investigate the effect of short-term exposure to indoor particles on blood pressure (BP). METHODS: We analyzed the association of particle emissions from indoor sources (candle burning, toasting bread, frying sausages) with BP changes in 54 healthy volunteers in a randomized cross-over controlled exposure study. Particle mass concentration (PMC), size-specific particle number concentration (PNC) and lung-deposited particle surface area concentration (PSC) were measured during the 2h exposure...
June 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/28661600/-criteria-and-clinical-significance-of-echographic-patterns-of-the-left-ventriculus-anomalous-deformity
#17
A S Matvashchuk, M V Kostvivev
With the aim of the clinical significance studying of the abnormal myocardial deforma- tion (MD) patterns in left ventricle (LV) there were examined 45 patients, in whom oper- ative myocardial revascularization was performed for an ischemic heart disease. Also 31 volunteers were examined. Postsystolic myocardial contruction (PMC) of the LV, depending on its mechanism, was classified: in absence of the affection - PMC-0, in presence of myocardial ischemia - PMC-1, in loss of contractility - PMC-2a, in loss of elasticity - PMC-2b...
August 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/28659813/human-peritoneal-mesothelial-cell-death-induced-by-high-glucose-hypertonic-solution-involves-ca-2-and-na-ions-and-oxidative-stress-with-the-participation-of-pkc-nox2-and-pi3k-akt-pathways
#18
Felipe Simon, Pablo Tapia, Ricardo Armisen, Cesar Echeverria, Sebastian Gatica, Alejandro Vallejos, Alejandro Pacheco, Maria E Sanhueza, Miriam Alvo, Erico Segovia, Rubén Torres
Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28651971/randomised-controlled-trial-of-a-text-messaging-intervention-for-reducing-processed-meat-consumption-the-mediating-roles-of-anticipated-regret-and-intention
#19
V Carfora, D Caso, M Conner
The present study aimed to extend the literature on text messaging interventions involved in promoting healthy eating behaviours. The theoretical framework was the Theory of Planned Behaviour (TPB). A randomized controlled trial was used to test the impact of daily text messages compared to no message (groups) for reducing processed meat consumption (PMC) over a 2 week period, testing the sequential mediation role of anticipated regret and intention on the relationship between groups and PMC reduction. PMC and TPB variables were assessed both at Time 1 and Time 2...
October 1, 2017: Appetite
https://www.readbyqxmd.com/read/28629253/insights-into-the-management-of-papillary-microcarcinoma-of-the-thyroid
#20
Akira Miyauchi, Yasuhiro Ito, Hitomi Oda
BACKGROUND: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs, i.e., PTCs ≤10 mm). Some researchers suggested small PTCs have been overdiagnosed and overtreated. In Japan, the active surveillance of patients with low-risk PMCs was initiated by Kuma Hospital (1993) and Tokyo's Cancer Institute Hospital (1995) based on the extremely higher incidences of both latent thyroid carcinomas in autopsy studies and small PTCs detected in mass screening studies using ultrasound examinations compared to the prevalence of clinical thyroid carcinoma...
June 19, 2017: Thyroid: Official Journal of the American Thyroid Association
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