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https://www.readbyqxmd.com/read/28917161/maternal-ssri-exposure-increases-the-risk-of-autistic-offspring-a-meta-analysis-and-systematic-review
#1
S Andalib, M R Emamhadi, S Yousefzadeh-Chabok, S K Shakouri, P F Høilund-Carlsen, M S Vafaee, T M Michel
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used to preclude maternal pregnancy depression. There is a growing body of literature assessing the association of prenatal exposure to SSRIs with autism spectrum disorder (ASD). The present systematic review and meta-analysis reviewed the medical literature and pooled the results of the association of prenatal exposure to SSRIs with ASD. METHODS: Published investigations in English by June 2016 with keywords of selective serotonin reuptake inhibitors, SSRI, autism spectrum disorder, ASD, pregnancy, childhood, children, neurodevelopment were identified using databases PubMed and PMC, MEDLINE, EMBASE, SCOPUS, and Google Scholar...
June 20, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28902812/-the-use-nicergoline-in-the-treatment-of-diabetes-mellitus
#2
I V Popova, A A Karpenko
Presented herein is a literature review aimed at investigating the appropriateness and possibility of using nicergoline (sermion) for treatment of patients suffering from diabetes mellitus. The analysis includes the most clinically significant results of scientific studies. The material to be reviewed was retrieved using the following key words: 'nicergoline', 'sermion', and 'diabetes mellitus' (with their respective Russian equivalents) in such databases as Medline, PubMed, ScienceDirect, PMC, Cochrane, as well as archives of both Russian and foreign journals, guidelines (clinical guidelines on rendering medical care for patients with diabetes mellitus, selected lectures on endocrinology)...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28877545/in-vivo-assessment-of-muscle-membrane-properties-in-the-sodium-channel-myotonias
#3
S Veronica Tan, Werner J Z'Graggen, Michael G Hanna, Hugh Bostock
INTRODUCTION: The gain-of-function mutations that underlie sodium channel myotonia(SCM) and paramyotonia congenita(PMC) produce differing clinical phenotypes. We used muscle velocity recovery cycles (MVRCs) to investigate membrane properties. METHODS: MVRCs and responses to trains of stimuli were compared in patients with SCM (n=9), PMC (N=8), and normal controls (n=26). RESULTS: The muscle relative refractory period was reduced in SCM, consistent with faster recovery of the mutant sodium channels from inactivation...
September 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28875950/blocking-posttranslational-core-fucosylation-ameliorates-rat-peritoneal-mesothelial-cell-epithelial-mesenchymal-transition
#4
Long-Kai Li, Nan Wang, Wei-Dong Wang, Xiang-Ning Du, Xin-Yu Wen, Ling-Yu Wang, Yi-Yao Deng, Da-Peng Wang, Hong-Li Lin
Background: Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) receptors. However, its effect on peritoneal fibrosis is unknown. Here, we investigated its influence on epithelial-mesenchymal transition (EMT) of rat peritoneal mesothelial cells (PMCs) in vitro induced by a high-glucose (HG) culture solution...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28852440/the-cardioprotective-effect-of-vanillic-acid-on-hemodynamic-parameters-malondialdehyde-and-infarct-size-in-ischemia-reperfusion-isolated-rat-heart-exposed-to-pm10
#5
Esmat Radmanesh, Mahin Dianat, Mohammad Badavi, Gholamreza Goudarzi, Seyyed Ali Mard
OBJECTIVES: Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS AND METHODS: Eighty male Wistar rats (250-300 g) were divided into 8 groups (n=10): Control, Sham, VAc, VA, PMa (0.5 mg/kg PM, intratracheal instillation), PMb (2...
July 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28840611/prospective-motion-correction-with-nmr-markers-using-only-native-sequence-elements
#6
Alexander Aranovitch, Maximilian Haeberlin, Simon Gross, Benjamin E Dietrich, Bertram J Wilm, David O Brunner, Thomas Schmid, Roger Luechinger, Klaas P Pruessmann
PURPOSE: To develop a method of tracking active NMR markers that requires no alterations of common imaging sequences and can be used for prospective motion correction (PMC) in brain MRI. METHODS: Localization of NMR markers is achieved by acquiring short signal snippets in rapid succession and evaluating them jointly. To spatially encode the markers, snippets are timed such that signal phase is accrued during sequence intervals with suitably diverse gradient actuation...
August 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28837443/effect-of-transcranial-direct-current-stimulation-on-severely-affected-arm-hand-motor-function-in-patients-after-an-acute-ischemic-stroke-a-pilot-randomized-control-trial
#7
Meheroz H Rabadi, Christopher E Aston
OBJECTIVE: The aim of this article was to determine whether cathodal transcranial direct current stimulation (c-tDCS) to unaffected primary motor cortex (PMC) plus conventional occupational therapy (OT) improves functional motor recovery of the affected arm hand in patients after an acute ischemic stroke compared with sham transcranial direct current stimulation plus conventional OT. DESIGN: In this prospective, randomized, double-blinded, sham-controlled trial of 16 severe, acute ischemic stroke patients with severe arm-hand weakness were randomly assigned to either experimental (c-tDCS plus OT; n = 8) or control (sham transcranial direct current stimulation plus OT; n = 8) groups...
October 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28836366/lipoteichoic-acid-upregulates-plasminogen-activator-inhibitor-1-expression-in-parapneumonic-effusions
#8
Kai-Ling Lee, Wei-Lin Chen, Ray-Jade Chen, Kevin S Lai, Chi-Li Chung
BACKGROUND AND OBJECTIVE: Parapneumonic effusion (PPE) is commonly caused by Gram-positive bacteria (GPB) and often presents with pleural loculation, which is characterized by overproduction of plasminogen activator inhibitor (PAI)-1. Lipoteichoic acid (LTA), a surface adhesion molecule of GPB, binds to the pleural mesothelium and triggers inflammation. However, the effects of LTA on PAI-1 expression in PPE and underlying mechanisms remain unclear. METHODS: Thirty consecutive patients with PPE were enrolled, including uncomplicated culture negative (CN, n = 11), Gram-negative bacteria (GNB, n = 7) and GPB (n = 12) groups stratified by pleural fluid characteristics and bacteriology, and the effusion PAI-1 levels were measured...
August 23, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28817414/systematic-selection-of-key-logistic-regression-variables-for-risk-prediction-analyses-a-five-factor-maximum-model
#9
Timothy E Hewett, Kate E Webster, Wendy J Hurd
GENERAL AND CRITICAL REVIEW FORMAT: The evolution of clinical practice and medical technology has yielded an increasing number of clinical measures and tests to assess a patient's progression and return to sport readiness after injury. The plethora of available tests may be burdensome to clinicians in the absence of evidence that demonstrates the utility of a given measurement. OBJECTIVE: Thus, there is a critical need to identify a discrete number of metrics to capture during clinical assessment to effectively and concisely guide patient care...
August 16, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28800626/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis
#10
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (Lox) is a key enzyme required for crosslinking and deposition of insoluble collagen, so we investigated whether targeting Lox might be an approach to reduce abdominal adhesions. METHODS: Female C57Bl/6 mice were treated intraperitoneally with multiwalled carbon nanotubes (NT) to induce fibrosis, together with chemical (ß-aminoproprionitrile-BAPN) or miRNA Lox inhibitors, progesterone or dexamethasone...
2017: PloS One
https://www.readbyqxmd.com/read/28782554/endocytosis-in-primary-mesenchyme-cells-during-sea-urchin-larval-skeletogenesis
#11
Christopher E Killian, Fred H Wilt
The sea urchin larval embryo elaborates two calcitic endoskeletal elements called spicules. Spicules are synthesized by the primary mesenchyme cells (PMCs) and begin to form at early gastrula stage. It is known that the calcium comprising the spicules comes from the seawater and we wish to further consider the mode of calcium transport from the extracellular seawater to the PMCs and then onto the forming spicules. We used PMC in vitro cultures, calcein, fluorescently labeled dextran, and fluorescently labeled Wheat Germ Agglutinin (WGA) to track calcium transport from the seawater into PMCs and spicules and to determine how molecules from the surface of PMCs interact with the incoming calcium...
August 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28782512/quantitative-expression-and-localization-of-gabab-receptor-protein-subunits-in-hippocampi-from-patients-with-refractory-temporal-lobe-epilepsy
#12
REVIEW
Mariam A Sheilabi, Dev Battacharyya, Laura Caetano, Maria Thom, Markus Reuber, John S Duncan, Alessandra P Princivalle
This study investigates GABAB protein expression and mRNA levels in three types of specimens. Two types of specimens from patients with temporal lobe epilepsy (TLE), secondary to hippocampal sclerosis, sclerotic hippocampal samples (TLE-HS), and tissue from the structurally preserved non-spiking ipsilateral superior temporal gyrus (TLE-STG) removed from the same patient during epilepsy surgery; and third specimen is hippocampal tissue from individuals with no history of epilepsy (post-mortem controls, PMC)...
August 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28770254/3d-correction-of-ais-in-braces-designed-using-cad-cam-and-fem-a-randomized-controlled-trial
#13
Nikita Cobetto, Carl-Éric Aubin, Stefan Parent, Soraya Barchi, Isabelle Turgeon, Hubert Labelle
BACKGROUND: Recent studies showed that finite element model (FEM) combined to CAD/CAM improves the design of braces for the conservative treatment of adolescent idiopathic scoliosis (AIS), using 2D measurements from in-brace radiographs. We aim to assess the immediate effectiveness on curve correction in all three planes of braces designed using CAD/CAM and numerical simulation compared to braces designed with CAD/CAM only. METHODS: SRS standardized criteria for bracing were followed to recruit 48 AIS patients who were randomized into two groups...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28761810/cerebellar-degeneration-affects-cortico-cortical-connectivity-in-motor-learning-networks
#14
Elinor Tzvi, Christoph Zimmermann, Richard Bey, Thomas F Münte, Matthias Nitschke, Ulrike M Krämer
The cerebellum plays an important role in motor learning as part of a cortico-striato-cerebellar network. Patients with cerebellar degeneration typically show impairments in different aspects of motor learning, including implicit motor sequence learning. How cerebellar dysfunction affects interactions in this cortico-striato-cerebellar network is poorly understood. The present study investigated the effect of cerebellar degeneration on activity in causal interactions between cortical and subcortical regions involved in motor learning...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28758029/concern-noted-a-descriptive-study-of-editorial-expressions-of-concern-in-pubmed-and-pubmed-central
#15
Melissa Vaught, Diana C Jordan, Hilda Bastian
BACKGROUND: An editorial expression of concern (EEoC) is issued by editors or publishers to draw attention to potential problems in a publication, without itself constituting a retraction or correction. METHODS: We searched PubMed, PubMed Central (PMC), and Google Scholar to identify EEoCs issued for publications in PubMed and PMC up to 22 August 2016. We also searched the archives of the Retraction Watch blog, some journal and publisher websites, and studies of EEoCs...
2017: Research Integrity and Peer Review
https://www.readbyqxmd.com/read/28752330/cortico-thalamic-disconnection-in-a-patient-with-supernumerary-phantom-limb
#16
Clémence Bourlon, Marika Urbanski, Romain Quentin, Christophe Duret, Eric Bardinet, Paolo Bartolomeo, Alexia Bourgeois
Supernumerary phantom limb (SPL) designates the experience of an illusory additional limb occurring after brain damage. Functional neuroimaging during SPL movements documented increased response in the ipsilesional supplementary motor area (SMA), premotor cortex (PMC), thalamus and caudate. This suggested that motor circuits are important for bodily related cognition, but anatomical evidence is sparse. Here, we tested this hypothesis by studying an extremely rare patient with chronic SPL, still present 3 years after a vascular stroke affecting cortical and subcortical right-hemisphere structures...
July 27, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#17
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28747834/analysis-of-consumers-preferences-and-price-sensitivity-to-native-chickens
#18
Min-A Lee, Yoojin Jung, Cheorun Jo, Ji-Young Park, Ki-Chang Nam
This study analyzed consumers' preferences and price sensitivity to native chickens. A survey was conducted from Jan 6 to 17, 2014, and data were collected from consumers (n=500) living in Korea. Statistical analyses evaluated the consumption patterns of native chickens, preference marketing for native chicken breeds which will be newly developed, and price sensitivity measurement (PSM). Of the subjects who preferred broilers, 24.3% do not purchase native chickens because of the dryness and tough texture, while those who preferred native chickens liked their chewy texture (38...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28730295/incarceration-of-the-medial-collateral-ligament-in-the-intercondylar-notch-following-proximal-avulsion
#19
Edward Walton, Martin Williams, James R Robinson
Intra-articular entrapment of the medial collateral ligament (MCL) is a rare but recognised complication of traumatic injury to the posteromedial corner (PMC) of the knee. Considering the MCL is the most commonly injured ligament of the knee this complication is extremely rare with only a handful of cases describing MCL entrapment following distal avulsion of the MCL. We present the first known case of MCL entrapment following proximal avulsion of the MCL and posterior oblique ligament (POL) with the mid-substance of the MCL becoming entrapped in the joint, lying on the superior surface of the medial meniscus and extending up into the intercondylar notch...
July 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28713629/abducent-nerve-palsy-after-microballoon-compression-of-the-trigeminal-ganglion-case-report
#20
Cassiano Marchi, Paulo Henrique Pires de Aguiar, Ana Maria Moura, Giovanna Matricardi, Carolina Utsunomya Muniz, Rogério Aires, Flávia Gehrke, Natally Santiago, Samuel Simis
BACKGROUND: Trigeminal neuralgia (TN) is the most common type of facial neuralgia with incidence of 26.8/100,000 person year. In general, this scenario is characterized by a lancinating, unilateral, paroxysmal pain in the area of the fifth cranial nerve. Several treatment methods, including the injection of ethyl alcohol or butyl alcohol into the ganglion, the glycerol injection into the trigeminal cistern, peripheral nerve divisions, the radiofrequency thermocoagulation of the preganglionic fibers, and radiosurgery has been used for TN...
2017: Surgical Neurology International
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