Fan Wu, Caiming Chen, Guo Lin, Chengkun Wu, Jingzhi Xie, Kongwen Lin, Xingchen Dai, Zhengyue Chen, Keng Ye, Ying Yuan, Zhimin Chen, Huabin Ma, Zishan Lin, Yanfang Xu
Hyperuricemia is an independent risk factor for chronic kidney disease (CKD) and promotes renal fibrosis, but the underlying mechanism remains largely unknown. Unresolved inflammation is strongly associated with renal fibrosis and is a well-known significant contributor to the progression of CKD, including hyperuricemia nephropathy. In the current study, we elucidated the impact of Caspase-11/Gasdermin D (GSDMD)-dependent neutrophil extracellular traps (NETs) on progressive hyperuricemic nephropathy. We found that the Caspase-11/GSDMD signaling were markedly activated in the kidneys of hyperuricemic nephropathy...
March 4, 2024: Cellular and Molecular Life Sciences: CMLS