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https://www.readbyqxmd.com/read/29677463/a-role-for-collagen-iv-in-cardiovascular-disease
#1
Lasse Bach Steffensen, Lars M Rasmussen
Over the past decade, studies have repeatedly found single nucleotide polymorphisms located in the COL4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of approximately 160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the ⍺1- and ⍺2-chains of collagen IV, a major component of basement membranes in various tissues including arteries. In spite of the growing body of evidence indicating a role for collagen IV in CVD, remarkably few studies aim at directly investigating such a role...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#2
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29676943/impact-of-preoperative-thrombocytopenia-on-the-outcome-after-coronary-artery-bypass-grafting
#3
Wail Nammas, Magnus Dalén, Stefano Rosato, Riccardo Gherli, Daniel Reichart, Giuseppe Gatti, Francesco Onorati, Giuseppe Faggian, Marisa De Feo, Ciro Bancone, Sidney Chocron, Sorosh Khodabandeh, Giuseppe Santarpino, Antonino S Rubino, Daniele Maselli, Saverio Nardella, Antonio Salsano, Tiziano Gherli, Francesco Nicolini, Marco Zanobini, Matteo Saccocci, Karl Bounader, Paola D'Errigo, Tuomas Kiviniemi, Eeva-Maija Kinnunen, Andrea Perrotti, Juhani Airaksinen, Giovanni Mariscalco, Vito G Ruggieri, Fausto Biancari
The impact of thrombocytopenia on postoperative bleeding and other major adverse events after cardiac surgery is unclear. This issue was investigated in a series of patients who underwent isolated coronary artery bypass grafting (CABG) from the prospective, multicenter E-CABG registry. Preoperative thrombocytopenia was defined as preoperative platelet count <150 × 109 /L and it was considered moderate-severe when preoperative platelet count was <100 × 109 /L. Multilevel mixed-effects regression analysis was performed to adjust the effect of thrombocytopenia on outcomes for baseline and operative covariates as well as for interinstitutional differences in patient-blood management...
April 20, 2018: Platelets
https://www.readbyqxmd.com/read/29676545/hemorheologic-alterations-in-patients-with-type-2-diabetes-mellitus-presented-with-an-acute-myocardial-infarction
#4
Kyu Hwan Park, Ung Kim, Kang Un Choi, Jong Ho Nam, Jung Hee Lee, Chan Hee Lee, Jang Won Son, Jong Seon Park, Dong Gu Shin, Kyu Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang Soo Suh
BACKGROUND: Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676045/prognostic-value-of-positive-t-wave-in-lead-avr-in-patients-with-non-st-segment-myocardial-infarction
#5
Ahmad Separham, Bahram Sohrabi, Arezou Tajlil, Leili Pourafkari, Robabeh Sadeghi, Samad Ghaffari, Nader D Nader
BACKGROUND: Lead aVR provides prognostic information in various settings in patients with ischemia. We aim to investigate the role of a positive T wave in lead aVR in non-ST segment myocardial infarction (NSTEMI). METHODS: In a prospective cohort study, we included 400 patients with NSTEMI. Presentation electrocardiogram (ECG) was investigated for presence of a positive T wave as well as ST segment elevation (STE) in aVR and study variables were compared. Predictors of primary outcome defined as hospital major adverse cardiovascular events (MACE) and secondary outcome, defined as three-vessel coronary disease and/or left main coronary artery stenosis (3VD/LMCA) stenosis in angiography, were determined in multivariate logistic regression analysis...
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29675968/giant-right-coronary-artery-aneurysm-mimicking-pericardial-tamponade
#6
Michal Hulman, Panagiotis Artemiou
No abstract text is available yet for this article.
April 19, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29675570/driving-ability-after-right-sided-puncture-of-the-common-femoral-artery-during-coronary-angiography
#7
Christoph Brenner, Raoul Fuehring, David Niederseer, Rudolf Kirchmair, Christian Haid, Michael Liebensteiner
OBJECTIVES/BACKGROUND: To assess brake reaction time (BRT; key factor in driving ability) in patients receiving transfemoral coronary angiography (CAG). We assumed that patients would have a significantly impaired BRT after the procedure. METHODS: A prospective, observational study design was applied. Consecutive patients undergoing right-sided transfemoral CAG as part of the clinical routine were included. An experimental driving simulator was used to determine BRT after receiving a visual stimulus...
April 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29675439/coronary-events-in-patients-presenting-for-repair-of-acute-type-a-aortic-dissection
#8
Paul C Tang, Shahab A Akhter, Satoru Osaki, Lucian Lozonschi, Takushi Kohmoto, Nilto C De Oliveira
Background: Preoperative coronary angiography is often not performed in acute Type A dissection. We examined differences in the incidence of pre-existing coronary disease and subsequent coronary events between patients undergoing acute Type A dissection repair and patients undergoing elective proximal aortic aneurysm repair. Methods: From 2000 to 2015, there were 154 acute Type A dissection repairs and 457 elective proximal aortic aneurysm repairs. We performed a retrospective review to evaluate preoperative coronary disease and postoperative coronary interventions such as percutaneous coronary intervention (PCI) and coronary bypass grafting (CABG)...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29675278/adrenocorticotropic-hormone-secreting-pheochromocytoma-underlying-glucocorticoid-induced-pheochromocytoma-crisis
#9
Gil A Geva, David J Gross, Haggi Mazeh, Karine Atlan, Iddo Z Ben-Dov, Matan Fischer
Context: Pheochromocytomas are hormone secreting tumors of the medulla of the adrenal glands found in 0.1-0.5% of patients with hypertension. The vast majority of pheochromocytomas secrete catecholamines, but they have been occasionally shown to also secrete interleukins, calcitonin, testosterone, and in rare cases adrenocorticotropic hormone. Pheochromocytoma crisis is a life threatening event in which high levels of catecholamines cause a systemic reaction leading to organ failure. Case Description: A 70-year-old man was admitted with acute myocardial ischemia following glucocorticoid administration as part of an endocrine workup for an adrenal mass...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29674972/gualou-xiebai-decoction-a-traditional-chinese-medicine-prevents-cardiac-reperfusion-injury-of-hyperlipidemia-rat-via-energy-modulation
#10
Lu-Lu Yan, Wei-Yang Zhang, Xiao-Hong Wei, Li Yan, Chun-Shui Pan, Yang Yu, Jing-Yu Fan, Yu-Ying Liu, Hua Zhou, Jing-Yan Han, Xin-Sheng Yao
Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK pathway. Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674764/image-quality-of-the-coronary-angiography-with-noise-reduction-technology-to-decrease-the-radiation-dose
#11
Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Keisuke Otsuki, Nobuyuki Miyake, Shinji Osumi, Kiyonori Yamaoka
We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674335/although-coronary-mortality-has-decreased-rates-of-cardiovascular-disease-remain-high-21-years-of-follow-up-comparing-cohorts-of-men-born-in-1913-with-men-born-in-1943
#12
Michael Fu, Annika Rosengren, Erik Thunström, Zacharias Mandalenakis, Lennart Welin, Kenneth Caidahl, Aldina Pivodic, You Zhong, Constantinos Ergatoudes, David Morales, Catharina Welin, Kurt Svärdsudd, Mikael Dellborg, Per-Olof Hansson
BACKGROUND: Despite a decline in mortality rates from cardiovascular disease (CVD) in the past few decades, the burden of CVD in a contemporary population remains inadequately addressed. Therefore, this study was aimed to investigate secular trends in mortality from coronary artery disease and all-cause mortality over 2 decades, by comparing 2 cohorts of men born 30 years apart and evaluate the prediction of the risk of CVD and all-cause death in a contemporary random sample of Swedish men...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29674289/novel-association-between-cdkal1-and-cholesterol-efflux-capacity-replication-after-gwas-based-discovery
#13
Eun Jeong Cheon, Do Hyeon Cha, Sung Kweon Cho, Hye-Min Noh, Sungha Park, Seok-Min Kang, Heon Yung Gee, Sang-Hak Lee
BACKGROUND AND AIMS: Although the importance of the functional properties of high-density lipoprotein (HDL) has been increasingly emphasized, studies on the genetic factors associated with HDL function are highly limited. The aim of this study was to identify genetic variants associated with an individual's cholesterol efflux capacity (CEC) using a genome-wide association study approach. METHODS: This study included a discovery group of 607 subjects with coronary artery disease and an independent replication group of 158 subjects...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29673931/-appropriate-use-of-red-blood-cell-transfusion-in-the-emergency-department-before-and-after-a-specific-protocol
#14
M-L Langlais, M Dargère, C Le Niger, D Goetghebeur
The purpose of this study was to assess appropriateness of red blood cell (RBC) transfusion in the emergency department before and after a specific protocol. METHODS: A retrospective monocenter study was realized during two six-month periods at the emergency unit. A protocol based on the French national guidelines (HAS) in 2014 was set up between the two periods. All the adult patients, except in a context of massive transfusion, were included in the study. The principal criteria analysed was the rate of appropriate transfusion...
April 16, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29673507/pre-angioplasty-instantaneous-wave-free-ratio-pullback-predicts-hemodynamic-outcome-in-humans-with-coronary-artery-disease-primary-results-of-the-international-multicenter-ifr-gradient-registry
#15
Yuetsu Kikuta, Christopher M Cook, Andrew S P Sharp, Pablo Salinas, Yoshiaki Kawase, Yasutsugu Shiono, Alessandra Giavarini, Masafumi Nakayama, Salvatore De Rosa, Sayan Sen, Sukhjinder S Nijjer, Rasha Al-Lamee, Ricardo Petraco, Iqbal S Malik, Ghada W Mikhail, Raffi R Kaprielian, Gilbert W M Wijntjens, Shinsuke Mori, Arata Hagikura, Martin Mates, Atsushi Mizuno, Farrel Hellig, Kelvin Lee, Luc Janssens, Kazunori Horie, Shah Mohdnazri, Raul Herrera, Florian Krackhardt, Masahiro Yamawaki, John Davies, Hideo Takebayashi, Thomas Keeble, Seiichi Haruta, Flavio Ribichini, Ciro Indolfi, Jamil Mayet, Darrel P Francis, Jan J Piek, Carlo Di Mario, Javier Escaned, Hitoshi Matsuo, Justin E Davies
OBJECTIVES: The authors sought to evaluate the accuracy of instantaneous wave-Free Ratio (iFR) pullback measurements to predict post-percutaneous coronary intervention (PCI) physiological outcomes, and to quantify how often iFR pullback alters PCI strategy in real-world clinical settings. BACKGROUND: In tandem and diffuse disease, offline analysis of continuous iFR pullback measurement has previously been demonstrated to accurately predict the physiological outcome of revascularization...
April 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29673405/gwas-implicated-risk-variants-in-different-genes-contribute-additively-to-increase-the-risk-of-coronary-artery-disease-cad-in-the-pakistani-subjects
#16
Saleem Ullah Shahid, N A Shabana, Abdul Rehman, Steve Humphries
BACKGROUND: Coronary artery disease (CAD) remains the single most important cause of mortality worldwide. Many candidate and GWAS genetic variants have been identified in the recent years. In the current study, we selected six SNPs from various genes that have originally been identified in GWAS studies and examined the association of SNPs individually and as a genetic risk score (GRS) with CAD and blood lipid levels in the Pakistani subjects. METHODS: Six hundred twenty-four (404 cases and 219 controls) subjects were genotyped for variants rs10757274 in CDKN2A gene, rs17465637 in MIA3 gene, rs7025486 in DAB2IP gene, rs17228212 in SMAD3 gene, rs981887 in MRAS gene and rs1746048 in CXCL12 gene, by TaqMan and KASPar allele discrimination techniques...
April 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29673380/a-standardized-approach-to-treat-complex-aortic-valve-endocarditis-a-case-series
#17
Anna Gomes, Jayant S Jainandunsing, Sander van Assen, Peter Paul van Geel, Bhanu Sinha, Sandro Gelsomino, Daniel M Johnson, Ehsan Natour
BACKGROUND: Surgical treatment of complicated aortic valve endocarditis often is challenging, even for experienced surgeons. We aim at demonstrating a standardized surgical approach by stentless bioprostheses for the treatment of aortic valve endocarditis complicated by paravalvular abscess formation. METHODS: Sixteen patients presenting with aortic valve endocarditis (4 native and 12 prosthetic valves) and paravalvular abscess formation at various localizations and to different extents were treated by a standardized approach using stentless bioprostheses...
April 19, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29673259/exploring-potential-biomarkers-associated-with-health-related-quality-of-life-in-patients-with-coronary-artery-disease-and-heart-failure
#18
Nijole Kazukauskiene, Julius Burkauskas, Jurate Macijauskiene, Narseta Mickuviene, Julija Brozaitiene
OBJECTIVE: There has been a lack of research examining associations between biomarkers and health-related quality of life (HRQoL) in patients with coronary artery disease and heart failure. In patients with coronary artery disease and heart failure, we aimed to explore potential associations between biomarkers of health such as serum levels of thyroid hormones, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), inflammatory biomarkers and HRQoL. METHODS: In sum, 482 patients (75% male; mean age 58±10 years) with coronary artery disease and heart failure were evaluated for socio-demographic and clinical coronary artery disease risk factors...
April 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29672995/transient-left-septal-fascicular-block-and-left-anterior-fascicular-block-as-a-consequence-of-proximal-subocclusion-of-the-left-anterior-descending-coronary-artery
#19
Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros, Rodrigo Daminello-Raimundo, Luiz Carlos de Abreu, Kjell Nikus
The association of left anterior fascicular block (LAFB) with left septal fascicular block (LSFB) characterizes a left bifascicular block subtype rarely described in the literature, probably due to the fact that most researchers are not aware of the existence of the left septal fascicle. We describe a case with this transient intraventricular dromotropic disturbance due to left anterior descending coronary artery subocclusion.
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29672700/systematic-bilateral-internal-mammary-artery-grafting-lessons-learned-from-the-catholic-university-extensive-bima-grafting-study
#20
Mario Gaudino, Franco Glieca, Nicola Luciani, Claudio Pragliola, Vasileios Tsiopoulos, Piergiorgio Bruno, Piero Farina, Giorgia Bonalumi, Natalia Pavone, Marialisa Nesta, Federico Cammertoni, Monica Munjal, Antonino Di Franco, Massimo Massetti
OBJECTIVES: Despite claims of feasibility, to date no study has examined the effect of systematic bilateral internal mammary artery (BIMA) use in a large cohort of real-world unselected patients. The CATHolic University EXtensive BIMA Grafting Study (CATHEXIS) registry was designed to assess the feasibility and safety of systematic BIMA grafting. METHODS: The CATHEXIS was a single-centre, prospective, observational, propensity-matched study. The study was supposed to include 2 arms of 500 patients each: a prospective arm and a retrospective arm...
April 16, 2018: European Journal of Cardio-thoracic Surgery
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