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CNS whipple's disease

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https://www.readbyqxmd.com/read/27593833/whipple-disease-confined-to-the-central-nervous-system-presenting-as-a-cystic-tumor-case-report-and-review-of-literature
#1
Mohamed Kilani, Leila Njim, Atef Ben Nsir, Mohamed Nejib Hattab
Although neurological features are commonly encountered in Whipple's disease (WD), presentation with purely neurologic patterns is uncommon. Exclusive confinement to the central nervous system (CNS) is extremely rare. In these cases, the development of isolated cerebral mass is exceptional. In the present paper, the authors describe a case of a 68-year-old man who presented with partial seizures. The neurological examination was normal. The imaging showed a cystic lesion. This tumor-like lesion was removed by performing frontal craniotomy...
May 5, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27336807/prosopagnosia-as-the-presenting-symptom-of-whipple-disease
#2
Miguel Tábuas-Pereira, Margarida Vicente, Filomena Coelho, Isabel Santana
Whipple disease is a rare, chronic multisystem infectious disease. The central nervous system (CNS) is secondarily involved in 43% of patients; 5% of patients have isolated or primary CNS involvement. The most frequent CNS symptoms are cognitive changes. Prosopagnosia is an inability to recognize familiar faces, in a person who does not have vision impairments or cognitive alterations. This relatively rare condition is usually related to vascular, traumatic, degenerative, or infectious lesions. We report a 54-year-old woman who presented subacutely with fever, headache, and seizures that led to a diagnosis of infectious meningoencephalitis...
June 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/26445540/primary-whipple-disease-of-the-brain-case-report-with-long-term-clinical-and-mri-follow-up
#3
Jan Peregrin, Hana Malikova
Whipple disease (WD) is a rare systemic disorder caused by the bacteria Tropheryma whipplei. In its classic form, it manifests with gastrointestinal problems including diarrhea, abdominal pain, and weight loss. However, various other systems can be affected, including the central nervous system (CNS). Even more rarely, the CNS is primarily affected without gastrointestinal symptoms and with a negative small bowel biopsy. The incidence of primary CNS WD is unknown. We report the case of a young female with the primary CNS form of WD...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26282456/isolated-cns-whipple-s-disease-a-diagnostic-dilemma
#4
Amartya Kundu, Parijat Sen, Sharad Khurana
No abstract text is available yet for this article.
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/25871025/magnetic-resonance-imaging-of-whipple-s-disease-confined-to-the-cns-presenting-with-multiple-intracerebral-mass-lesions
#5
Masoud Poureisa, Mohammad Hossein Daghighi, Haidar Esmaili, Ramin Mazaheri-Khameneh
We report a patient diagnosed with Whipple's disease (WD) who presented only with neurological symptoms. Neuroimaging (MRI) showed lesions with marked mass effect similar to infiltrative tumors, which were hypersignal on long TR and hyposignal on short TR images, located in several areas of the brain. In serial controls, lesions resolved with gliosis and atrophic changes as well as migration of active infiltrative-like lesions to new areas. MR findings of the brain WD are discussed, which confirmed by stereotactic brain biopsy...
2015: Acta Medica Iranica
https://www.readbyqxmd.com/read/25171900/neurologic-manifestations-of-gastrointestinal-and-liver-diseases
#6
REVIEW
José M Ferro, Sofia Oliveira
Hepatic and gastrointestinal disorders can produce a wide spectrum of neurologic complications both affecting the central nervous system (CNS) and the peripheral nervous system. These manifestations range in severity from coma in acute liver failure and acute pancreatitis, to minor cognitive changes in chronic portosystemic encephalopathy and hepatitis C. Cerebrovascular diseases can complicate hepatitis C infection and inflammatory bowel disease. Demyelinating disorders may co-exist with inflammatory bowel disease...
October 2014: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/24320005/clinical-and-neuropathological-variability-in-clinically-isolated-central-nervous-system-whipple-s-disease
#7
Mircea Balasa, Ellen Gelpi, M J Rey, Jordi Vila, Lluís Ramió-Torrentà, Ana Ma Quiles Granado, Ricard Molina Latorre, Hubert Lepidi, Didier Raoult, Albert Saiz
Central nervous system Whipple's disease (CNS-WD) with clinically isolated neurological involvement is a rare condition fatal without an early diagnosis. We aimed to present clinical and neuropathological features of three cases of pre- or post-mortem polymerase chain reaction confirmed CNS-WD with distinct clinical presentation, outcome and pathological findings. One patient had an acute onset with spinal and brainstem involvement and died without CNS-WD diagnosis after 14 weeks. Neuropathology showed extensive inflammatory and necrotizing lesions with abundant foamy periodic-acid-Schiff (PAS)+ macrophages...
April 2014: Brain Pathology
https://www.readbyqxmd.com/read/24145700/central-nervous-system-involvement-in-whipple-disease-clinical-study-of-18-patients-and-long-term-follow-up
#8
Caroline Compain, Karim Sacre, Xavier Puéchal, Isabelle Klein, Denis Vital-Durand, Jean-Luc Houeto, Thomas De Broucker, Didier Raoult, Thomas Papo
Whipple disease (WD) is a rare multisystemic infection with a protean clinical presentation. The central nervous system (CNS) is involved in 3 situations: CNS involvement in classic WD, CNS relapse in previously treated WD, and isolated CNS infection. We retrospectively analyzed clinical features, diagnostic workup, brain imaging, cerebrospinal fluid (CSF) study, treatment, and follow-up data in 18 patients with WD and CNS infection. Ten men and 8 women were included with a median age at diagnosis of 47 years (range, 30-56 yr)...
November 2013: Medicine (Baltimore)
https://www.readbyqxmd.com/read/23170246/isolated-cns-whipple-disease-with-normal-brain-mri-and-false-positive-csf-14-3-3-protein-a-case-report-and-review-of-the-literature
#9
Victor W Sung, Michael J Lyerly, Kenneth B Fallon, Khurram Bashir
Whipple disease (WD) is usually a systemic infectious disease that can have central nervous system (CNS) involvement. WD confined to the CNS is extremely rare and difficult to diagnose, but can be fatal if not treated in a timely fashion. We present the case of a 42-year-old man with a subacute dementia accompanied by a movement disorder consisting of progressive supranuclear gaze palsy, myoclonus, and ataxia. Our patient lacked the typical magnetic resonance imaging (MRI) findings reported with isolated CNS WD and had a false-positive cerebrospinal fluid (CSF) 14-3-3 protein...
November 2012: Brain and Behavior
https://www.readbyqxmd.com/read/21696776/isolated-intracranial-whipple-s-disease-report-of-a-rare-case-and-review-of-the-literature
#10
REVIEW
Wazim Mohamed, Erin Neil, William J Kupsky, Csaba Juhász, Sandeep Mittal, Sunitha Santhakumar
INTRODUCTION: Whipple's disease (WD) is a rare multisystemic infectious disease that can involve a variety of organs namely the gastrointestinal tract, lymphatic system, heart and nervous system. Myorhythmia is a hallmark of WD. Isolated CNS involvement is very rare. CASE: We present a 50 year-old African-American woman with rapid cognitive decline, visual hallucinations, insomnia, dysarthria, and gait unsteadiness. She subsequently developed pendular nystagmus and gaze paresis...
September 15, 2011: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/21667114/-tropheryma-whipplei-infection-colonization-self-limiting-infection-and-whipple-s-disease
#11
REVIEW
V Moos, C Loddenkemper, T Schneider
Whipple's disease is a multisystemic infection caused by the ubiquitous bacterium Tropheryma whipplei. Immunological host factors enable classical Whipple's disease; however, T. whipplei can be found in three other clinical conditions: healthy colonization, self-limiting infections, and isolated endocarditis. The genetic predisposition of the host rather than the genotype of the bacterium influences the infection. Modern diagnostic methods elucidate the many facets of Whipple's disease. In particular, isolated T...
September 2011: Der Pathologe
https://www.readbyqxmd.com/read/20537789/recurrent-acute-obstructive-hydrocephalus-as-clinical-onset-of-cerebral-whipple-s-disease
#12
Vincenzo Seneca, Alessia Imperato, Giuseppe Colella, Valentina Cioffi, Giuseppe Mariniello, Michelangelo Gangemi
Whipple's disease is a rare multisystemic infection caused by the intracellular bacteria Thropheryma whippelii. Central nervous system (CNS) involvement is not rare. The most frequent CNS manifestations are cognitive and behavioural changes, sopranuclear ophtalmoplegia, myoclonus, epilepsy, ataxia, meningitis and focal cerebral palsy. We report one case of cerebral localization of Whipple's disease with a clinical presentation of recurrent endocranic hypertension and hydrocephalus, and uncommon neurological symptoms, successfully treated by endoscopic third ventriculostomy and antibiotic therapy with ceftriaxone and Trimethoprim-Sulfamethoxazole...
October 2010: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/20395395/mr-imaging-of-central-nervous-system-whipple-disease-a-15-year-review
#13
D F Black, A J Aksamit, J M Morris
CNS WD is fatal if antibiotics are not begun early, but knowledge regarding the variety of presentations on MR imaging is limited. In order to more effectively recognize this entity on MR imaging, the Mayo Clinic medical records were reviewed for subjects diagnosed with CNS WD from 1992-2006 who had also undergone MR imaging of the neuraxis. Seven subjects were identified and their imaging findings were reviewed by the authors. Four of 7 had head MR imaging findings indicative of WD. Two subjects demonstrated high T2 signal within the corticospinal tracts...
September 2010: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/19897965/new-insights-into-whipple-s-disease-a-rare-intestinal-inflammatory-disorder
#14
REVIEW
Thomas Marth
Whipple's disease (WD) is a rare systemic infectious disorder caused by the actinomycete Tropheryma whipplei. This chronic disease, first described by Whipple as 'intestinal lipodystrophy', affects preferentially middle-aged white men who may present with weight loss, diarrhea, abdominal pain and arthralgia. Thus, it represents an important differential diagnosis of chronic diarrhea. A variety of other clinical patterns, such as involvement of the heart, lung, or central nervous system (CNS), are frequent. In addition, individuals with isolated heart valve involvement or asymptomatic carriers may be observed...
2009: Digestive Diseases
https://www.readbyqxmd.com/read/19612977/whipple-disease-of-the-central-nervous-system-an-unusual-occurrence-in-association-with-acquired-immune-deficiency-syndrome
#15
Bharat Guthikonda, Emilie Rouah, Bhuvanaswari Krishnan, Suzanne Z Powell, J Clay Goodman, Shankar P Gopinath, Richard K Simpson
Whipple disease is a multisystem infectious disease caused by Tropheryma whippleii. It commonly affects the CNS and produces neurological symptoms in 10-20% of cases. Central nervous system Whipple disease occurring in patients with AIDS is extremely rare. The authors present a case of a newly diagnosed AIDS patient in whom intracranial Whipple disease was diagnosed by stereotactic brain biopsy.
May 2010: Journal of Neurosurgery
https://www.readbyqxmd.com/read/19194653/isolated-whipple-disease-of-the-brain-resembling-a-tumour
#16
James L Frazier, Alfredo Quinones-Hinojosa
INTRODUCTION: Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms. DISCUSSION: For those patients with systemic signs and symptoms of Whipple disease, 6% to 43% will have clinically manifested CNS involvement that may include alterations in personality, ataxia, and dementia. We report our experience with a patient, who was successfully treated for Whipple disease 12 years prior to presentation and had a magnetic resonance image of the brain that revealed two solitary lesions resembling a tumor upon presentation...
February 2009: Acta Neurochirurgica
https://www.readbyqxmd.com/read/18638806/rapidly-progressive-whipple-s-disease-of-the-central-nervous-system
#17
R Niekrash, C McLean, A Kaye, R Hjorth, P Desmond, V Sinicaks, M Gonzales
We describe a patient with rapidly progressive Whipple's disease confined to the central nervous system (CNS). The diagnosis was made pre-mortem following stereotactic and open brain biopsis and confirmed at autopsy. Despite appropriate antibiotic treatment, the disease ran a fulminant course to death after nine weeks.
April 1995: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/18319513/possible-case-of-cns-whipple-s-disease-in-an-adolescent-with-aids
#18
Sameer J Patel, Richard C Huard, Christian Keller, Marc Foca
An adolescent with HIV/AIDS presented subacutely with progressive encephalopathy, spastic quadraplegia, and diarrhea. His brain biopsy was suggestive of central nervous system Whipple's disease, a disease rarely described in HIV patients. Due to overlapping, nonspecific symptoms associated with several opportunistic infections and to the difficulty in culturing the causative organism Tropheryma whipplei, Whipple's disease may be more common than previously suspected, and it is an important consideration in patients with AIDS...
March 2008: Journal of the International Association of Physicians in AIDS Care: JIAPAC
https://www.readbyqxmd.com/read/17846404/isolated-cns-whipple-disease-with-a-variant-of-oculofacial-skeletal-myorhythmia-ofsm
#19
D Ciampi de Andrade, R C Nogueira, L T Lucato, P E Marchiori, L R Machado, M J Teixeira, M Scaff
No abstract text is available yet for this article.
September 11, 2007: Neurology
https://www.readbyqxmd.com/read/17577831/isolated-cns-whipple-disease-acute-onset-and-relapsing-remitting-course
#20
Julián Benito-León, Javier Arpa, Elan D Louis, Inmaculada Herrera, Asia De La Loma
Isolated CNS Whipple disease (WD) carries a poor prognosis, particularly if untreated. We describe 2 patients with isolated CNS WD who presented unusually with an acute onset followed by a relapsing-remitting course. Neither was diagnosed with WD until they had had several relapses.
2007: Scandinavian Journal of Infectious Diseases
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