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https://www.readbyqxmd.com/read/28545710/evaluation-of-hyperspectral-imaging-technology-in-patients-with-peripheral-vascular-disease
#1
Nathaniel Chiang, Jitendra K Jain, Jamie Sleigh, Thodur Vasudevan
BACKGROUND: Hyperspectral imaging technology is a novel method of using transcutaneous measurement of oxyhemoglobin (HT-Oxy) and deoxyhemoglobin (HT-Deoxy) concentrations to create a two-dimensional, color-coded "oxygen map." The aims of this study were to compare the use of a hyperspectral imaging device with the transcutaneous oxygen measurement (TCOM), ankle-brachial index (ABI), and severity of peripheral vascular disease (PVD) and to assess their correlations. METHODS: This prospective study recruited 294 participants divided into three distinct groups composed of healthy volunteers and patients with PVD...
May 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28545600/hydrocarbon-assessment-and-prediction-due-to-the-gulf-war-oil-disaster-north-kuwait
#2
Yohannes Yihdego, Radwan A Al-Weshah
  Oil spill in the Gulf was the biggest disaster in history. The scale of damage was enormous, ranging from destruction caused by oil fires and oil spills, to economic decline for the Kuwaiti oil industry. The transport modelling of the freshwater aquifers in north Kuwait was undertaken to assess potential remediation scenarios using the MODFLOW-SURFACT numerical code. Three interlinked models were calibrated: flow, density (salinity), and transport. The model domain is a subregional area encompassing the Al-Raudhatain and Umm Al-Aish Basins...
June 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28525268/rational-design-of-novel-allosteric-dihydrofolate-reductase-inhibitors-showing-antibacterial-effects-on-drug-resistant-e-coli-escape-variants
#3
Bharath Srinivasan, João V Rodrigues, Sam Tonddast-Navaei, Eugene Shakhnovich, Jeffrey Skolnick
In drug-discovery, systematic variations of substituents on a common scaffold and bioisosteric replacements are often used to generate diversity and obtain molecules with better biological effects. However, this could saturate the small-molecule diversity pool resulting in drug-resistance. On the other hand, conventional drug-discovery relies on targeting known pockets on protein surfaces leading to drug resistance by mutations of critical pocket residues. Here, we present a two-pronged strategy of designing novel drugs that target unique pockets on a protein's surface to overcome the above problems...
May 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28524032/-preoperative-risk-factors-analysis-of-pulmonary-hypertension-crisis-during-perioperative-period-for-caesarean-section-of-woman-with-severe-pulmonary-hypertension
#4
Chunlei Zhang, Yaguang Liu, Enming Qing, Jun Ma
OBJECTIVE: To analyze preoperative risk factors of perioperative pulmonary hypertension crisis (PHC) for pregnant woman with severe pulmonary artery hypertension (PAH), and approach its clinical value. METHODS: A retrospective analysis was conducted. The clinical data from 152 pregnant women with severe PAH underwent cesarean delivery admitted to Beijing Anzhen Hospital from January 1st 2008 to December 31st 2016 was collected. The patients were divided into two groups according to with perioperative PHC or not...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28522407/high-throughput-screening-and-bioinformatic-analysis-to-ascertain-compounds-that-prevent-saturated-fatty-acid-induced-%C3%AE-cell-apoptosis
#5
Seung-Hee Lee, Daniel Cunha, Carlo Piermarocchi, Giovanni Paternostro, Anthony Pinkerton, Laurence Ladriere, Piero Marchetti, Decio L Eizirik, Miriam Cnop, Fred Levine
Pancreatic β-cell lipotoxicity is a central feature of the pathogenesis of type 2 diabetes. To study the mechanism by which fatty acids cause β-cell death and develop novel approaches to prevent it, a high-throughput screen on the β-cell line INS1 was carried out. The cells were exposed to palmitate to induce cell death and compounds that reversed palmitate-induced cytotoxicity were ascertained. Hits from the screen were analyzed by an increasingly more stringent testing funnel, ending with studies on primary human islets treated with palmitate...
May 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28522352/immune-plasma-for-the-treatment-of-severe-influenza-an-open-label-multicentre-phase-2-randomised-study
#6
John H Beigel, Pablo Tebas, Marie-Carmelle Elie-Turenne, Ednan Bajwa, Todd E Bell, Charles B Cairns, Shmuel Shoham, Jaime G Deville, Eric Feucht, Judith Feinberg, Thomas Luke, Kanakatte Raviprakash, Janine Danko, Dorothy O'Neil, Julia A Metcalf, Karen King, Timothy H Burgess, Evgenia Aga, H Clifford Lane, Michael D Hughes, Richard T Davey
BACKGROUND: Influenza causes substantial morbidity and mortality despite available treatments. Anecdotal reports suggest that plasma with high antibody titres to influenza might be of benefit in the treatment of severe influenza. METHODS: In this randomised, open-label, multicentre, phase 2 trial, 29 academic medical centres in the USA assessed the safety and efficacy of anti-influenza plasma with haemagglutination inhibition antibody titres of 1:80 or more to the infecting strain...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28512555/assessment-of-obesity-and-hepatic-late-adverse-effects-in-the-egyptian-survivors-of-pediatric-acute-lymphoblastic-leukemia-a-single-center-study
#7
Farida H El-Rashedy, Mahmoud A El-Hawy, Sally M El Hefnawy, Mona M Mohammed
BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) with current cure rates reaching 80% emphasizes the necessity to determine treatment-related long-term effects. The aim of this study is to estimate the prevalence of overweight, obesity, and hepatic late adverse effects in a cohort of ALL survivors treated at the Hematology and Oncology Unit, Pediatrics Department, Menoufia University, Egypt. METHODS: In this case-control study, height, weight, and body mass index (BMI) were assessed for 35 pediatric ALL survivors and 35 healthy children...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28496182/characterization-of-off-odours-and-potentially-harmful-substances-in-a-fancy-dress-accessory-handbag-for-children
#8
Christoph Wiedmer, Cristina Velasco-Schön, Andrea Buettner
A fancy dress accessory handbag for children was claimed by consumers to exhibit an offensive smell. Sensory characterization by an expert panel revealed, amongst others, rubber- and car tire - like notes. For elucidation of the molecular reasons of this sensory defect, the volatile fraction of the product was isolated by means of solvent extraction and high vacuum distillation. Identification of the main odorants was accomplished by means of one- and two-dimensional gas chromatography, with parallel mass spectrometric and olfactometric detection...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495082/synthesis-and-%C3%AE-glucosidase-inhibition-activity-of-dihydroxy-pyrrolidines
#9
Sivaprasad Kasturi, Sujatha Surarapu, Srinivas Uppalanchi, Jaya Shree Anireddy, Shubham Dwivedi, Hasitha Shilpa Anantaraju, Yogeeswari Perumal, Dilep Kumar Sigalapalli, Bathini Nagendra Babu, Krishna S Ethiraj
A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as α-glucosidase inhibitors were designed and synthesized. The biological screening test against α-glucosidase showed that some of these compounds have the positive inhibitory activity against α-glucosidase. Saturated aliphatic amides were more potent than the olefinic amides. Among all the compounds, 5o/6o having polar -NH2 group, 10f/11f having polar -OH group on phenyl ring displayed 3-4-fold more potent than the standard drugs...
May 2, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28490779/large-scale-phosphoprotein-profiling-to-explore-drosophila-cold-acclimation-regulatory-mechanisms
#10
Hervé Colinet, Charles Pineau, Emmanuelle Com
The regulatory mechanisms involved in the acquisition of thermal tolerance are unknown in insects. Reversible phosphorylation is a widespread post-translational modification that can rapidly alter proteins function(s). Here, we conducted a large-scale comparative screening of phosphorylation networks in adult Drosophila flies that were cold-acclimated versus control. Using a modified SIMAC method followed by a multiple MS analysis strategy, we identified a large collection of phosphopeptides (about 1600) and phosphoproteins (about 500) in both groups, with good enrichment efficacy (80%)...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489862/novel-genes-associated-with-enhanced-motility-of-escherichia-coli-st131
#11
Asha Kakkanat, Minh-Duy Phan, Alvin W Lo, Scott A Beatson, Mark A Schembri
Uropathogenic Escherichia coli (UPEC) is the cause of ~75% of all urinary tract infections (UTIs) and is increasingly associated with multidrug resistance. This includes UPEC strains from the recently emerged and globally disseminated sequence type 131 (ST131), which is now the dominant fluoroquinolone-resistant UPEC clone worldwide. Most ST131 strains are motile and produce H4-type flagella. Here, we applied a combination of saturated Tn5 mutagenesis and transposon directed insertion site sequencing (TraDIS) as a high throughput genetic screen and identified 30 genes associated with enhanced motility of the reference ST131 strain EC958...
2017: PloS One
https://www.readbyqxmd.com/read/28481201/functional-mapping-of-yeast-genomes-by-saturated-transposition
#12
Agnès Henria Michel, Riko Hatakeyama, Philipp Kimmig, Meret Arter, Matthias Peter, Joao Matos, Claudio De Virgilio, Benoît Kornmann
Yeast is a powerful model for systems genetics. We present a versatile, time- and labor-efficient method to functionally explore the Saccharomyces cerevisiae genome using saturated transposon mutagenesis coupled to high-throughput sequencing. SAturated Transposon Analysis in Yeast (SATAY) allows one-step mapping of all genetic loci in which transposons can insert without disrupting essential functions. SATAY is particularly suited to discover loci important for growth under various conditions. SATAY (1) reveals positive and negative genetic interactions in single and multiple mutant strains, (2) can identify drug targets, (3) detects not only essential genes, but also essential protein domains, (4) generates both null and other informative alleles...
May 8, 2017: ELife
https://www.readbyqxmd.com/read/28477347/p4-medicine-approach-to-obstructive-sleep-apnoea
#13
REVIEW
Diane C Lim, Kate Sutherland, Peter A Cistulli, Allan I Pack
P4 medicine is an evolving approach to personalized medicine. The four Ps offer a means to: Predict who will develop disease and co-morbidities; Prevent rather than react to disease; Personalize diagnosis and treatment; have patients Participate in their own care. P4 medicine is very applicable to obstructive sleep apnoea (OSA) because each OSA patient has a different pathway to disease and its consequences. OSA has both structural and physiological mechanisms with different clinical subgroups, different molecular profiles and different consequences...
May 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28475043/color-retinal-image-enhancement-based-on-luminosity-and-contrast-adjustment
#14
Mei Zhou, Kai Jin, Shaoze Wang, Juan Ye, Dahong Qian
OBJECTIVE: Many common eye diseases and cardiovascular diseases can be diagnosed through retinal imaging. However, due to uneven illumination, image blurring, and low contrast, retinal images with poor quality are not useful for diagnosis, especially in automated image analyzing systems. Here we propose a new image enhancement method to improve color retinal image luminosity and contrast. METHODS: A luminance gain matrix, which is obtained by gamma correction of the value channel in the HSV (Hue, Saturation, and Value) color space, is used to enhance the R, G, and B (Red, Green and Blue) channels, respectively...
May 3, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28464223/casting-eppcr-ceppcr-a-simple-random-mutagenesis-method-to-generate-high-quality-mutant-libraries
#15
Jianhua Yang, Anna J Ruff, Marcus Arlt, Ulrich Schwaneberg
During the last decade, directed evolution has become a standard protein engineering strategy to reengineer proteins for industrial applications under high stress conditions (e.g., high temperature, extreme pH, ionic liquids, or organic solvents). The most commonly employed method for diversity generation to improve biocatalysts for these properties is random mutagenesis by error-prone polymerase chain reaction (epPCR). However, recent reports show that epPCR often fails to produce >70% of beneficial positions/amino acid exchanges which improve enzyme properties such as organic solvent or ionic liquid resistance...
May 2, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28462727/a-prospective-evaluation-of-the-depression-nutrient-intake-reverse-causality-hypothesis-in-a-cohort-of-community-dwelling-older-canadians
#16
Laura Gougeon, Hélène Payette, José A Morais, Pierrette Gaudreau, Bryna Shatenstein, Katherine Gray-Donald
Studies have investigated the potential protective effects that diet may have on late-life depression incidence. This disorder can, however, affect the person's food intake, widely known as the reverse causality hypothesis of depression. To test this hypothesis, we compared mean nutrient intakes from three 24-h recalls during the year depression was detected (Geriatric Depression Scale ≥11 or antidepressant medication) with intakes from 1 year earlier among community-dwelling older adults (67-83 years) followed up annually in the 4-year Québec Longitudinal Study on Nutrition and Aging, who were free of depression and cognitive impairment at baseline...
May 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28456232/new-method-of-extracting-information-of-arterial-oxygen-saturation-based-on-%C3%A2
#17
Wenting Dai, Ling Lin, Gang Li
Noninvasive detection of oxygen saturation with near-infrared spectroscopy has been widely used in clinics. In order to further enhance its detection precision and reliability, this paper proposes a method of time domain absolute difference summation (∑|Δ|) based on a dynamic spectrum. In this method, the ratio of absolute differences between intervals of two differential sampling points at the same moment on logarithm photoplethysmography signals of red and infrared light was obtained in turn, and then they obtained a ratio sequence which was screened with a statistical method...
April 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28454553/ambulatory-oxygen-in-fibrotic-lung-disease-ambox-study-protocol-for-a-randomised-controlled-trial
#18
Dina Visca, Vicky Tsipouri, Letizia Mori, Ashi Firouzi, Sharon Fleming, Morag Farquhar, Elizabeth Leung, Toby M Maher, Paul Cullinan, Nick Hopkinson, Athol U Wells, Winston Banya, Jennifer A Whitty, Huzaifa Adamali, Lisa G Spencer, Piersante Sestini, Elisabetta A Renzoni
BACKGROUND: Fibrotic interstitial lung diseases (ILDs) are chronic and often progressive conditions resulting in substantial morbidity and mortality. Shortness of breath, a symptom often linked to oxygen desaturation on exertion, is tightly linked to worsening quality of life in these patients. Although ambulatory oxygen is used empirically in their treatment, there are no ILD-specific guidelines on its use. To our knowledge, no studies are available on the effects of ambulatory oxygen on day-to-day life in patients with ILD...
April 28, 2017: Trials
https://www.readbyqxmd.com/read/28448538/combined-lipidomic-and-proteomic-analysis-of-isolated-human-islets-exposed-to-palmitate-reveals-time-dependent-changes-in-insulin-secretion-and-lipid-metabolism
#19
Kirsten Roomp, Hjalti Kristinsson, Domitille Schvartz, Kumari Ubhayasekera, Ernest Sargsyan, Levon Manukyan, Azazul Chowdhury, Hannes Manell, Venkata Satagopam, Karlfried Groebe, Reinhard Schneider, Jonas Bergquist, Jean-Charles Sanchez, Peter Bergsten
Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specific cellular pathways or organs. Our aim was to, firstly, develop a combined lipidomics and proteomics approach for lipotoxicity in isolated human islets and, secondly, investigate if the approach could delineate novel and/ or confirm reported mechanisms of lipotoxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28448043/challenges-in-rheological-characterization-of-highly-concentrated-suspensions-a-case-study-for-screen-printing-silver-pastes
#20
Ceren Yüce, Norbert Willenbacher
A comprehensive rheological characterization of highly concentrated suspensions or pastes is mandatory for a targeted product development meeting the manifold requirements during processing and application of such complex fluids. In this investigation, measuring protocols for a conclusive assessment of different process relevant rheological parameters have been evaluated. This includes the determination of yield stress, viscosity, wall slip velocity, structural recovery after large deformation and elongation at break as well as tensile force during filament stretching...
April 10, 2017: Journal of Visualized Experiments: JoVE
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