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https://www.readbyqxmd.com/read/28634248/suburban-families-experience-with-food-insecurity-screening-in-primary-care-practices
#1
Deepak Palakshappa, Stephanie Doupnik, Aditi Vasan, Saba Khan, Leah Seifu, Chris Feudtner, Alexander G Fiks
BACKGROUND: Food insecurity (FI) remains a major public health problem. With the rise in suburban poverty, a greater understanding of parents' experiences of FI in suburban settings is needed to effectively screen and address FI in suburban practices. METHODS: We conducted 23 semistructured interviews with parents of children <4 years of age who presented for well-child care in 6 suburban pediatric practices and screened positive for FI. In the interviews, we elicited parents' perceptions of screening for FI, how FI impacted the family, and recommendations for how practices could more effectively address FI...
June 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28631933/a-salt-reduction-smartphone-app-supports-lower-salt-food-purchases-for-people-with-cardiovascular-disease-findings-from-the-saltswitch-randomised-controlled-trial
#2
Helen Eyles, Rebecca McLean, Bruce Neal, Yannan Jiang, Robert N Doughty, Rachael McLean, Cliona Ni Mhurchu
Background SaltSwitch is an innovative smartphone application (app) that enables shoppers to scan the barcode of a packaged food and receive an immediate, interpretive, traffic light nutrition label on the screen, along with suggestions for lower salt alternatives. Our aim was to determine the effectiveness of SaltSwitch to support people with cardiovascular disease to make lower salt food choices. Design Six-week, two-arm, parallel, randomised controlled trial in Auckland, New Zealand (2 weeks baseline and 4 weeks intervention)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28625228/warnings-as-a-directive-front-of-pack-nutrition-labelling-scheme-comparison-with-the-guideline-daily-amount-and-traffic-light-systems
#3
Alejandra Arrúa, Leandro Machín, María Rosa Curutchet, Joseline Martínez, Lucía Antúnez, Florencia Alcaire, Ana Giménez, Gastón Ares
OBJECTIVE: Warnings have recently been proposed as a new type of directive front-of-pack (FOP) nutrition labelling scheme to flag products with high content of key nutrients. In the present work, this system was compared with the two most common FOP nutrition labelling schemes (Guideline Daily Amounts (GDA) and traffic-light system) in terms of goal-directed attention, influence on perceived healthfulness and ability to differentiate between products. Design/Setting/Subjects Goal-directed attention to FOP labels was evaluated using a visual search task in which participants were presented with labels on a computer screen and were asked to indicate whether labels with high sodium content were present or absent...
June 19, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28619185/high-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-rls-wed-among-people-living-at-high-altitude-in-the-indian-himalaya
#4
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
BACKGROUND: At high altitude, prevalence of restless legs syndrome has been found to be greater than expected in small population-based studies, which did not use validated tools for identification of RLS. However, it is not known as to whether this increased prevalence is associated with altitude or increased risk factors for RLS in these populations or errors in identification of RLS. METHOD: This population based, door-to-door study was conducted at low altitude (400 m above sea level) and high altitudes (1900-2000 m and 3200 m above sea level) using random stratified sampling in Himalayan and sub-Himalayan region of India...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28606655/mortality-in-pulmonary-arterial-hypertension-due-to-congenital-heart-disease-serial-changes-improve-prognostication
#5
M T U Schuijt, I M Blok, A H Zwinderman, A C M J van Riel, M J Schuuring, R J de Winter, A L Duijnhouwer, A P J van Dijk, B J M Mulder, B J Bouma
BACKGROUND: Adult patients with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) suffer from high mortality. This underlines the importance of adequate risk stratification to guide treatment decisions. Several baseline parameters are associated with mortality, however, their prognostic value may weaken after years of follow-up. Therefore we investigated the prognostic value of serial changes in standard clinical parameters in PAH-CHD. METHODS: In this prospective observational cohort study we included consecutive PAH-CHD adults, between 2005 and 2016...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28601895/site-saturation-mutagenesis-library-construction-and-screening-for-specific-broad-spectrum-single-domain-antibodies-against-multiple-cry1-toxins
#6
Lingxia Jiao, Yuan Liu, Xiao Zhang, Beibei Liu, Cunzheng Zhang, Xianjin Liu
Potential ecological environmental and food safety risks of various Cry toxins of Bacillus thuringiensis (Bt) in transgenic food have received gradually increasing attention, which urged to establish an efficient and broad-spectrum detection technology for Cry toxins. Based on the single-domain antibody (sdAb) A8 against Bt Cry1Ab toxin screened from the humanized domain antibody library, the key amino acids of sdAb (A8) binding five kinds of Cry1 toxins were predicted using homology modeling and molecular docking technology, and the results showed that 105th asparagine, 106th arginine, 107th valine, and 114th arginine, respectively, located in heavy-chain complementarity-determining region 3 were common key amino acid sites...
June 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28601756/using-atmospheric-plasma-to-increase-wettability-imbibition-and-germination-of-physically-dormant-seeds-of-mimosa-caesalpiniafolia
#7
A R M da Silva, M L Farias, D L S da Silva, J O Vitoriano, R C de Sousa, C Alves-Junior
In this study, we analyzed seed wettability as well as imbibition and germination after treatment with atmospheric pressure cold plasma (APCP) using dielectric barrier discharge (DBD) in seeds that have very low germination rates. To aid industrial applications, several seeds were simultaneously treated with plasma within a space between two coaxial glass tubes sandwiched by two metal mesh screens that produced high-voltage pulses at 17.5kV with a frequency of 990Hz. Three treatment times (3min, 9min and 15min) as well as untreated seeds were used to conduct the wettability, imbibition and germination tests...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28599970/cerebral-near-infrared-spectroscopy-insensitively-detects-low-cerebral-venous-oxygen-saturations-after-stage-1-palliation
#8
Erin Rescoe, Xiaoqi Tang, Dorothy Alison Perry, Lynn A Sleeper, James A DiNardo, Barry D Kussman, John N Kheir
BACKGROUND: Measurement of cerebral venous oxyhemoglobin saturation (ScvO2) is considered a gold standard in assessing the adequacy of tissue oxygen delivery (DO2) after the stage 1 palliation (S1P), with SvO2 <30% often representing severely compromised DO2. Regional oxygenation index (rSO2) based on near-infrared resonance spectroscopy (NIRS) frequently is used to screen for compromised DO2, although its sensitivity to detect severe abnormalities in SvO2 is uncertain. METHODS: ScvO2 was measured by co-oximetry from the internal jugular vein as clinically indicated in 73 neonates after S1P...
May 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28599651/microtiter-plate-cultivation-of-oleaginous-fungi-and-monitoring-of-lipogenesis-by-high-throughput-ftir-spectroscopy
#9
Gergely Kosa, Achim Kohler, Valeria Tafintseva, Boris Zimmermann, Kristin Forfang, Nils Kristian Afseth, Dimitrios Tzimorotas, Kiira S Vuoristo, Svein Jarle Horn, Jerome Mounier, Volha Shapaval
BACKGROUND: Oleaginous fungi can accumulate lipids by utilizing a wide range of waste substrates. They are an important source for the industrial production of omega-6 polyunsaturated fatty acids (gamma-linolenic and arachidonic acid) and have been suggested as an alternative route for biodiesel production. Initial research steps for various applications include the screening of fungi in order to find efficient fungal producers with desired fatty acid composition. Traditional cultivation methods (shake flask) and lipid analysis (extraction-gas chromatography) are not applicable for large-scale screening due to their low throughput and time-consuming analysis...
June 9, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28597617/iron-monitoring-of-male-and-female-rugby-sevens-players-over-an-international-season
#10
Anthea C Clarke, Judith M Anson, Christine E Dziedzic, Warren A McDonald, David B Pyne
BACKGROUND: Given the likely influence that high training loads, contact-induced haemolysis and female-specific requirements have on the incidence of iron deficiency, characterising the direction and magnitude of fluctuations in iron status over an international season is important for managing player health and physical performance in rugby sevens. METHODS: Australian national male (n=27) and female (n=23) rugby sevens players undertook blood tests at pre-season, mid-season, and end-season...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28590477/evaluation-of-ligand-based-nmr-screening-methods-to-characterize-small-molecule-binding-to-hiv-1-glycoprotein-41
#11
Shidong Chu, Guangyan Zhou, Miriam Gochin
Small molecule inhibitors of glycoprotein-41 (gp41) are able to prevent HIV infection by binding to a hydrophobic pocket (HP) contained within the gp41 ectodomain, and preventing progression of fusion. There is little structural information on gp41-ligand complexes, owing to hydrophobicity of the ligands, occlusion of the HP in folded gp41 ectodomain, and failure to form crystals of complexes. Here we used an engineered gp41 ectodomain protein containing an exposed HP and a small molecule designed to bind with weak affinity to the HP...
June 28, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28587401/antioxidant-properties-of-the-red-alga-asparagopsis-taxiformis-collected-on-the-north-west-algerian-coast
#12
Zoheir Mellouk, Ilhem Benammar, Djamil Krouf, Makhlouf Goudjil, Meriem Okbi, Willy Malaisse
The aim of the present study was to evaluate the total phenolic and lipid content, fatty acids profiles and in vitro antioxidant activities of aqueous and solvent extracts of the red seaweed Asparagopsis taxiformis, through six different investigations. The present study demonstrated that phenol contents (mg gallic acid/g dry weight) were highest in the aqueous and methanolic extracts, followed by the ethanolic, hydroethanolic and hydromethanolic extracts. The lowest phenol contents were identified in the three remaining extracts: Butanolic, petroleum ether and acetone extracts...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586139/ni-ni-oh-2-core-shell-particles-partially-covering-silicon-photoanode-for-enhanced-efficiency-and-stability-of-photoelectrochemical-water-oxidation
#13
Shicheng Yan, Zhe Xu, Zhan Shi, Lang Pei, Zhengbin Gu, Zhigang Zou
One main barrier for enhancing solar energy conversion by photoelectrochemical (PEC) water splitting devices is the charge separation and transport efficiency at the interface region of the photoanode and electrolyte. Here, we electrodeposited the core-shell structured Ni@Ni(OH)2 nanoparticles on the surface of n-type Si photoanode with island distribution. We found that the Schottky barrier between Ni and Si is sensitive to the thickness of Ni(OH)2 shell. The photovoltage output of the photoanode increases with increasing the thickness of Ni(OH)2 shell, closely associating with the interaction between Ni and Ni(OH)2 that depends on the electrolyte screening effect and p-type feature of Ni(OH)2 layer...
June 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28581894/identification-of-small-molecule-noncovalent-binders-utilizing-samdi-technology
#14
Erica C VanderPorten, Michael D Scholle, John Sherrill, John C Tran, Yichin Liu
In recent years, the ability to unambiguously identify complex mixtures of analytes with high accuracy and resolving power in a label-free format continues to expand the application of mass spectrometry (MS) in the drug discovery process. This advantage combined with improved instrumentation makes MS suitable for targets with limited alternative assays for high-throughput screening (HTS). We describe a novel screening format using Self-Assembled Monolayers and matrix-assisted laser Desorption Ionization (SAMDI) technology...
June 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28576321/quantification-of-gene-specific-dna-methylation-in-oesophageal-cancer-via-electrochemistry
#15
Md Hakimul Haque, Vinod Gopalan, Md Nazmul Islam, Mostafa Kamal Masud, Ripon Bhattacharjee, Md Shahriar Al Hossain, Nam-Trung Nguyen, Alfred K Lam, Muhammad J A Shiddiky
Development of simple and inexpensive method for the analysis of gene-specific DNA methylation is important for the diagnosis and prognosis of patients with cancer. Herein, we report a relatively simple and inexpensive electrochemical method for the sensitive and selective detection of gene-specific DNA methylation in oesophageal cancer. The underlying principle of the method relies on the affinity interaction between DNA bases and unmodified gold electrode. Since the affinity trend of DNA bases towards the gold surface follows as adenine (A) > cytosine (C) > guanine (G)> thymine (T), a relatively larger amount of bisulfite-treated adenine-enriched unmethylated DNA adsorbs on the screen-printed gold electrodes (SPE-Au) in comparison to the guanine-enriched methylated sample...
July 11, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28574461/innovative-high-throughput-saxs-methodologies-based-on-photonic-lab-on-a-chip-sensors-application-to-macromolecular-studies
#16
Isaac Rodríguez-Ruiz, Dimitri Radajewski, Sophie Charton, Nhat Phamvan, Martha Brennich, Petra Pernot, Françoise Bonneté, Sébastien Teychené
The relevance of coupling droplet-based Photonic Lab-on-a-Chip (PhLoC) platforms and Small-Angle X-Ray Scattering (SAXS) technique is here highlighted for the performance of high throughput investigations, related to the study of protein macromolecular interactions. With this configuration, minute amounts of sample are required to obtain reliable statistical data. The PhLoC platforms presented in this work are designed to allow and control an effective mixing of precise amounts of proteins, crystallization reagents and buffer in nanoliter volumes, and the subsequent generation of nanodroplets by means of a two-phase flow...
June 2, 2017: Sensors
https://www.readbyqxmd.com/read/28569339/high-resolution-melting-as-a-rapid-reliable-accurate-and-cost-effective-emerging-tool-for-genotyping-pathogenic-bacteria-and-enhancing-molecular-epidemiological-surveillance-a-comprehensive-review-of-the-literature
#17
M Tamburro, G Ripabelli
INTRODUCTION: Rapid, reliable and accurate molecular typing methods are essential for outbreaks detection and infectious diseases control, for monitoring the evolution and dynamics of microbial populations, and for effective epidemiological surveillance. The introduction of a novel method based on the analysis of melting temperature of amplified products, known as High Resolution Melting (HRM) since 2002, has found applications in epidemiological studies, either for identification of bacterial species or molecular typing, as well as an extensive and increasing use in many research fields...
July 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28560042/acetylcholinesterase-and-butyrylcholinesterase-in-cardiosurgical-patients-with-postoperative-delirium
#18
Mira John, E Wesley Ely, Dorothee Halfkann, Julika Schoen, Beate Sedemund-Adib, Stefan Klotz, Finn Radtke, Sebastian Stehr, Michael Hueppe
BACKGROUND: Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found a potentially important role of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in delirium of critically ill patients on non-surgical ICU or in non-cardiac-surgery patients. We tested the hypothesis that AChE and BChE have an impact on patients after cardiac surgery with postoperative delirium...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28557364/supine-awake-oximetry-as-a-screening-tool-for-daytime-hypercapnia-in-super-obese-patients
#19
Yewon Chung, Frances Louise Garden, Adelle S Jee, Subash Srikantha, Saurabh Gupta, Peter Richard Buchanan, Peter Wallace Collett, Guy Barrington Marks, Hima Vedam
AIMS: To determine the validity of supine awake oximetry as a test for daytime hypercapnia and severe sleep disordered breathing in super-obese patients and to provide evidence to support its use as a screening tool for these disorders in this high-risk patient population. METHODS: Cross-sectional diagnostic test evaluation of super-obese adults (BMI >50 kg/m(2) ) presenting to Liverpool Hospital, Australia, between 2009 and 2015 for diagnostic polysomnography and arterial blood gas measurement...
May 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28555713/how-older-persons-perceive-the-loss-of-independence-the-need-of-a-holistic-approach-to-frailty
#20
E Escourrou, M Cesari, B Chicoulaa, B Fougère, B Vellas, S Andrieu, S Oustric
BACKGROUND: Since 2004, the definition of the frailty syndrome has shifted from purely physical criteria to a more comprehensive consideration of the individual, including their psychosocial criteria. In this study, qualitative research methods were used as a complementary approach in order to enrich the existing quantitative results in this area. OBJECTIVE: To understand the views of older persons on the risk of loss of independence. METHODS: The study population comprised people over 75 years of age who were living at home in the south-west of France and were considered to be at risk of losing their independence...
2017: Journal of Frailty & Aging
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