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Saturation screening

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https://www.readbyqxmd.com/read/29776787/the-value-of-peripheral-perfusion-index-measurements-for-early-detection-of-critical-cardiac-defects
#1
Ozgun Uygur, Ozge Altun Koroglu, Erturk Levent, Merve Tosyali, Mete Akisu, Mehmet Yalaz, Nilgun Kultursay
BACKGROUND: Approximately 25% of congenital heart diseases (CHD) are estimated to be critical and require an intervention. In this study, we aimed to investigate the additional value of peripheral perfusion index (PPI) measurements to pulse oximetry screening for critical CHD (CCHD). METHODS: Infants born at Ege University Hospital between May 2013 and September 2015 were prospectively included in the study. In addition to physical examination, pre- and postductal oxygen saturations and PPI values were measured with a new generation pulse oximeter before discharge from the hospital...
April 12, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29770396/screening-effects-on-the-field-enhancement-factor-of-zigzag-graphene-nanoribbon-arrays-a-first-principles-study
#2
Han Hu, Tzu-Chien Lin, Tsan-Chuen Leung, Wan-Sheng Su
The field screening effect on the electronic and field-emission properties of zigzag graphene nanoribbons (ZGNRs) has been studied using first-principles calculations. We have systematically investigated the effects of inter-ribbon distance and ribbon width on the work function, field enhancement factor, band gap and edge magnetism of zigzag graphene nanoribbons (ZGNRs). It is found that the work function of ZGNRs increases rapidly as the inter-ribbon distance Dx increases, which is caused by the positive dipole at the edge of the ribbon...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29767947/application-of-calcium-binding-motif-of-e-cadherin-for-electrochemical-detection-of-pb-ii
#3
Hamid R Lotfi Zadeh Zhad, Rebecca Y Lai
We report, for the first time, the use of a 13-amino-acid peptide sequence derived from the calcium-binding site of E-cadherin in the fabrication of an electrochemical peptide-based (E-PB) Pb(II) sensor. The sensing mechanism is analogous to that of previously developed E-PB sensors. Binding of Pb(II) rigidifies the surface-immobilized and methylene blue (MB)-modified peptide probe, thereby limiting the accessibility of the tethered MB to the electrode surface. This change in probe flexibility results in a reduction in the MB current that is dependent on the target concentration...
May 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29766170/design-of-a-wearable-device-for-real-time-screening-of-urinary-tract-infection-and-kidney-disease-based-on-smartphone
#4
Jianyu Zhou, Tao Dong
In this study, we developed a novel wearable and low-cost device for qualitative screening of glucose (GLU), leukocytes (LEU), and nitrite (NIT) and for semi-quantitative analysis of blood (BLD) and proteins (PRO) in the urine samples. The device can be attached to a diaper, and the results can be read by an app. The main functions of the device can be divided into sample collection, valve closing, and pad saturation; the recorded times for valve closing and pad saturation at four corners and pad saturation at the central parts are pseudo-medians (Hodges-Lehmann estimator) of 3...
May 16, 2018: Analyst
https://www.readbyqxmd.com/read/29765443/management-of-cardiac-hemochromatosis
#5
Wilbert S Aronow
Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration. Cardiac hemochromatosis is characterized by a dilated cardiomyopathy with dilated ventricles, reduced ejection fraction, and reduced fractional shortening. Deposition of iron may occur in the entire cardiac conduction system, especially the atrioventricular node. Cardiac hemochromatosis should be considered in any patient with unexplained heart failure...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29762716/crispor-intuitive-guide-selection-for-crispr-cas9-genome-editing-experiments-and-screens
#6
Jean-Paul Concordet, Maximilian Haeussler
CRISPOR.org is a web tool for genome editing experiments with the CRISPR-Cas9 system. It finds guide RNAs in an input sequence and ranks them according to different scores that evaluate potential off-targets in the genome of interest and predict on-target activity. The list of genomes is continuously expanded, with more 150 genomes added in the last two years. CRISPOR tries to provide a comprehensive solution from selection, cloning and expression of guide RNA as well as providing primers needed for testing guide activity and potential off-targets...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29762670/hens-ranked-as-highly-feed-efficient-have-an-improved-albumen-quality-profile-and-increased-polyunsaturated-fatty-acids-in-the-yolk
#7
Y Akter, S Greenhalgh, M R Islam, C Hutchison, C J O'Shea
The shelf-life of eggs which contain elevated levels of polyunsaturated fatty acids (PUFA) is compromised due to the relative instability and therefore greater potential for lipid peroxidation of unsaturated fatty acids (FA). Poultry that are highly feed efficient (HFE) exhibit higher systemic levels of antioxidant enzymes, and therefore may produce eggs with improved albumen quality and favorable FA profiles that are stable over time. We tested the hypothesis that HFE laying hens produce eggs with improved internal egg quality and a favorable yolk FA profile prior to and following storage...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29760993/assessing-blood-vessel-perfusion-and-vital-signs-through-retinal-imaging-photoplethysmography
#8
Harnani Hassan, Sheila Jaidka, Vincent M Dwyer, Sijung Hu
One solution to the global challenge of increasing ocular disease is a cost-effective technique for rapid screening and assessment. Current ophthalmic imaging techniques, e.g. scanning and ocular blood flow systems, are expensive, complex to operate and utilize invasive contrast agents during assessment. The work presented here demonstrates a simple retinal imaging photoplethysmography (iPPG) system with the potential to provide screening, diagnosis, monitoring and assessment that is non-invasive, painless and radiationless...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29758725/onset-of-density-driven-instabilities-in-fractured-aquifers
#9
Seyed Mostafa Jafari Raad, Hassan Hassanzadeh
Linear stability analysis is conducted to study the onset of density-driven convection involved in solubility trapping of CO_{2} in fractured aquifers. The effect of physical properties of a fracture network on the stability of a diffusive boundary layer in a saturated fractured porous media is investigated using the dual porosity concept. Linear stability analysis results show that both fracture interporosity flow and fracture storativity play an important role in the stability behavior of the system. It is shown that a diffusive boundary layer under the gravity field in fractured porous media with lower fracture storativity and/or higher fracture interporosity flow coefficient is more stable...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29754910/lifestyle-advice-and-interventions-for-cardiovascular-risk-reduction-a-systematic-review-of-guidelines
#10
Mohammed Y Khanji, Claudia N van Waardhuizen, Vinícius V S Bicalho, Bart S Ferket, M G Myriam Hunink, Steffen E Petersen
BACKGROUND: Lifestyle factors are important in preventing cardiovascular disease (CVD) development. We aimed to systematically review guidelines on primary prevention of CVD and their recommendations on lifestyle advice or intervention, in order to guide primary prevention programs. METHODS: Publications in MEDLINE, CINAHL over 7 years since May 3, 2009 were identified. G-I-N International Guideline Library, National Guidelines Clearinghouse, National Library for Health Guideline finder, Canadian Medical Association InfoBase were searched...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754874/preoperative-screening-for-obstructive-sleep-apnea-and-outcomes-in-pacu
#11
Jill Setaro, Ruth Reinsel, Dana Brun
PURPOSE: Practice guidelines from the perianesthesia community suggest that preoperative identification of patients with obstructive sleep apnea (OSA) and standardized longer observation in postanesthesia care unit (PACU) promotes safety after general anesthesia. The purpose of this study was to determine if longer monitoring of patients with OSA in the PACU improves patient outcomes after general anesthesia. DESIGN: Evidence-based best practices literature review...
May 10, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29754228/dynamic-management-of-codon-compression-for-saturation-mutagenesis
#12
Gur Pines, Ryan T Gill
Saturation mutagenesis is conveniently located between the two extremes of protein engineering, namely random mutagenesis, and rational design. It involves mutating a confined number of target residues to other amino acids, and hence requires knowledge regarding the sites for mutagenesis, but not their final identity. There are many different strategies for performing and designing such experiments, ranging from simple single degenerate codons to codon collections that code for distinct sets of amino acids...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29753012/significant-improvement-of-the-nitrilase-activity-by-semi-rational-protein-engineering-and-its-application-in-the-production-of-iminodiacetic-acid
#13
Zhi-Qiang Liu, Ming-Ming Lu, Xin-Hong Zhang, Feng Cheng, Jian-Miao Xu, Ya-Ping Xue, Li-Qun Jin, Yuan-Shan Wang, Yu-Guo Zheng
Iminodiacetic acid (IDA) is widely used as an intermediate in the manufacturing of chelating agents, glyphosate herbicides and surfactants. To improve activity and tolerance to the substrate for IDA production, Acidovorax facilis nitrilase was selected for further modification by the gene site saturation mutagenesis method. After screened by a two-step screening method, the best mutant (Mut-F168V/T201N/S192F/M191T/F192S) was selected. Compared to the wild-type nitrilase, Mut-F168V/T201N/S192F/M191T/F192S showed 136% improvement in specific activity...
May 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29748228/how-to-use-saturation-monitoring-in-newborns
#14
Steven McVea, Michael McGowan, Bharathi Rao
Pulse oximetry is a first-line monitoring tool, used in neonatal medicine routinely as a part of continuous monitoring during intensive care. It is also used to guide response to resuscitation and as a screening tool for congenital heart disease. Despite its widespread use, many healthcare providers are unaware of the underlying principles and limitations of pulse oximetry in neonates. In this article, we will discuss the physiological and technological principles behind the use of saturation monitoring and its use in neonatal practice...
May 10, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29747936/pulmonary-screening-in-subjects-after-the-fontan-procedure
#15
Deborah R Liptzin, Michael V Di Maria, Adel Younoszai, Michael R Narkewicz, Sarah L Kelly, Kelly R Wolfe, Livia A Veress
OBJECTIVES: To review the pulmonary findings of the first 51 patients who presented to our interdisciplinary single-ventricle clinic after undergoing the Fontan procedure. STUDY DESIGN: We performed an Institutional Review Board-approved retrospective review of 51 patients evaluated following the Fontan procedure. Evaluation included history, physical examination, pulmonary function testing, and 6-minute walk. Descriptive statistics were used to describe the population and testing data...
May 7, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29736941/two-dimensional-simulation-of-eccentric-photorefraction-images-for-ametropes-factors-influencing-the-measurement
#16
Yifei Wu, Larry N Thibos, T Rowan Candy
PURPOSE: Eccentric photorefraction and Purkinje image tracking are used to estimate refractive state and eye position simultaneously. Beyond vision screening, they provide insight into typical and atypical visual development. Systematic analysis of the effect of refractive error and spectacles on photorefraction data is needed to gauge the accuracy and precision of the technique. METHODS: Simulation of two-dimensional, double-pass eccentric photorefraction was performed (Zemax)...
May 7, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29731786/an-update-work-of-pulse-oximetry-screening-for-detecting-critical-congenital-heart-disease-in-the-newborn
#17
A Taksande, R Meshram, A Lohakare, S Purandare, U Biyani, J Vagha
Background: Congenital Heart Disease (CHD) is the commonest group of congenital malformations and affects 7-8 per 1000 live born newborns. Nevertheless, it is estimated that more than 50% of babies with undiagnosed CHD are not detected by routine neonatal cardiac examination. Aim: To find the incidence of CHD in newborns and to determine the accuracy of pulse oximetry for detecting clinically unrecognized critical congenital heart disease (CCHD) in the newborns...
July 2017: Images in Paediatric Cardiology
https://www.readbyqxmd.com/read/29731424/combining-promiscuous-acyl-coa-oxidase-and-enoyl-coa-carboxylase-reductases-for-atypical-polyketide-extender-unit-biosynthesis
#18
Bastian Vögeli, Kyra Geyer, Patrick D Gerlinger, Sarah Benkstein, Niña Socorro Cortina, Tobias J Erb
The incorporation of different extender units generates structural diversity in polyketides. There is significant interest in engineering substrate specificity of polyketide synthases (PKSs) to change their chemical structure. Efforts to change extender unit selectivity are hindered by the lack of simple screening methods and easily available atypical extender units. Here, we present a chemo-biosynthetic strategy that employs biocatalytic proofreading and allows access to a large variety of extender units...
April 21, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29728048/impact-of-bioactive-peptide-motifs-on-molecular-structure-charging-and-non-fouling-properties-of-poly-ethylene-oxide-brushes
#19
Ognen Pop-Georgievski, Ralf Zimmermann, Ilya Kotelnikov, Vladimir Proks, Dirk Romeis, Jan Kucka, Anja Caspari, Frantisek Rypacek, Carsten Werner
Polymer layers capable of suppressing protein adsorption from biological media while presenting extracellular matrix derived peptide motifs offer valuable new options for biomimetic surface engineering. Herein, we provide detailed insights into physico-chemical changes induced in a non-fouling poly(ethylene oxide) (PEO) brush/polydopamine (PDA) system by incorporation of adhesion ligand (RGD) peptides. Brushes with high surface chain densities (σ ≥ 0.5 chains·nm-2 ) and pronounced hydrophilicity (water contact angles ≤ 10°) were prepared by end-tethering of hetero-bifunctional PEOs (Mn ~ 20000 g∙mol-1 ) to PDA-modified surfaces from a reactive melt...
May 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29726345/mortality-and-morbidity-in-acutely-ill-adults-treated-with-liberal-versus-conservative-oxygen-therapy-iota-a-systematic-review-and-meta-analysis
#20
Derek K Chu, Lisa H-Y Kim, Paul J Young, Nima Zamiri, Saleh A Almenawer, Roman Jaeschke, Wojciech Szczeklik, Holger J Schünemann, John D Neary, Waleed Alhazzani
BACKGROUND: Supplemental oxygen is often administered liberally to acutely ill adults, but the credibility of the evidence for this practice is unclear. We systematically reviewed the efficacy and safety of liberal versus conservative oxygen therapy in acutely ill adults. METHODS: In the Improving Oxygen Therapy in Acute-illness (IOTA) systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, HealthSTAR, LILACS, PapersFirst, and the WHO International Clinical Trials Registry from inception to Oct 25, 2017, for randomised controlled trials comparing liberal and conservative oxygen therapy in acutely ill adults (aged ≥18 years)...
April 28, 2018: Lancet
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