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Hao Wang, Richard D Robinson, John S Garrett, Kellie Bunch, Charles A Huggins, Katherine Watson, Joni Daniels, Brett Banks, James P D'Etienne, Nestor R Zenarosa
Background. The accuracy and utility of current Emergency Department (ED) crowding estimation tools remain uncertain in EDs with high annual volumes. We aimed at deriving a more accurate tool to evaluate overcrowding in a high volume ED setting and determine the association between ED overcrowding and patient care outcomes. Methods. A novel scoring tool (SONET: Severely overcrowded-Overcrowded-Not overcrowded Estimation Tool) was developed and validated in two EDs with both annual volumes exceeding 100,000...
2015: Emergency Medicine International
Hao Wang, Richard D Robinson, Chad D Cowden, Violet A Gorman, Christopher D Cook, Eugene K Gicheru, Chet D Schrader, Rani D Jayswal, Nestor R Zenarosa
OBJECTIVES: To derive a tool to determine Urgent Care Center (UCC) crowding and investigate the association between different levels of UCC overcrowding and negative patient care outcomes. DESIGN: Prospective pilot study. SETTING: Single centre study in the USA. PARTICIPANTS: 3565 patients who registered at UCC during the 21-day study period were included. Patients who had no overcrowding statuses estimated due to incomplete collection of operational variables at the time of registration were excluded in this study...
2015: BMJ Open
Luc Xerri, Emmanuel Bachy, Bettina Fabiani, Danielle Canioni, Catherine Chassagne-Clément, Peggy Dartigues-Cuilléres, Frédéric Charlotte, Nicole Brousse, Marie-Christine Rousselet, Charles Foussard, Pauline Brice, Pierre Feugier, Frank Morschhauser, Anne Sonet, Daniel Olive, Gilles Salles
Detection of MUM1+ cells in follicular lymphoma (FL) tissues was previously found to be associated with poor prognosis in a single report, whereas the usefulness of Ki-67 immunostaining remains debated. Our goal was to establish whether these markers have predictive value for patients with FL. We analyzed MUM1 and Ki-67 expression using immunohistochemistry in biopsy samples from 434 patients from the PRIMA randomized trial. The MUM1 prognostic value was then validated in a cohort of 138 patients from the FL2000 randomized trial, using the optimal cutoff value obtained from the PRIMA cohort...
October 2014: Human Pathology
Nathalie Nols, Nicolas Mounier, Salima Bouazza, Renaud Lhommel, Sabrina Costantini, Thierry Vander Borght, Marie-Christiane Vekemans, Anne Sonet, André Bosly, Lucienne Michaux, Marc André, Eric Van Den Neste
The prognostic value of interim (18)fluorodeoxyglucose positron emission tomography (i-PET) was investigated in 73 patients (median age 60 years) with diffuse large B-cell lymphoma (DLBCL). i-PET was analyzed using the Deauville score (DS) and change in maximum standardized uptake value (ΔSUV(max)). Patients with a DS of 1-3 demonstrated a significantly (p < 0.0001) better outcome (median follow-up 2.4 years) than patients with a score of 4 or 5 in terms of event-free survival (EFS) (79% vs. 36%), progression-free survival (PFS) (84% vs...
April 2014: Leukemia & Lymphoma
Emmanuel Bachy, Roch Houot, Franck Morschhauser, Anne Sonet, Pauline Brice, Karim Belhadj, Guillaume Cartron, Bruno Audhuy, Christophe Fermé, Pierre Feugier, Catherine Sebban, Vincent Delwail, Hervé Maisonneuve, Steven Le Gouill, Sophie Lefort, Nicole Brousse, Charles Foussard, Gilles Salles
Anti-CD20-containing chemotherapy regimens have become the standard of care for patients with follicular lymphoma needing cytotoxic therapy. Four randomized trials demonstrated a clinical benefit for patients treated with rituximab. However, no long-term follow up (i.e. > 5 years) of these trials is yet available. Between May 2000 and May 2002, 358 newly diagnosed patients with high tumor burden follicular lymphoma were randomized to receive cyclophosphamide, adriamycin, etoposide and prednisolone plus interferon-α2a or a similar chemotherapy-based regimen plus rituximab, and outcome was up-dated...
July 2013: Haematologica
Amanda Elton, Jonathan Young, Sonet Smitherman, Robin E Gross, Tanja Mletzko, Clinton D Kilts
Cocaine dependence is defined by a loss of inhibitory control over drug-use behaviors, mirrored by measurable impairments in laboratory tasks of inhibitory control. The current study tested the hypothesis that deficits in multiple subprocesses of behavioral control are associated with reliable neural-processing alterations that define cocaine addiction. While undergoing functional magnetic resonance imaging (fMRI), 38 cocaine-dependent men and 27 healthy control men performed a stop-signal task of motor inhibition...
May 2014: Addiction Biology
David Sibon, Marion Fournier, Josette Brière, Laurence Lamant, Corinne Haioun, Bertrand Coiffier, Serge Bologna, Pierre Morel, Jean Gabarre, Olivier Hermine, Anne Sonet, Christian Gisselbrecht, Georges Delsol, Philippe Gaulard, Hervé Tilly
PURPOSE: Systemic anaplastic large-cell lymphoma (ALCL) is a T-cell lymphoma, whose anaplastic lymphoma kinase (ALK) expression varies according to age. Long-term outcomes of chemotherapy-treated adults are not definitively established and should be evaluated. PATIENTS AND METHODS: Patients treated in three Groupe d'Étude des Lymphomes de l'Adulte prospective clinical trials with confirmed systemic ALCL after immunohistopathologic review and defined ALK expression status were analyzed...
November 10, 2012: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
C Viscoli, R Herbrecht, H Akan, L Baila, A Sonet, A Gallamini, A Giagounidis, O Marchetti, R Martino, L Meert, M Paesmans, L Ameye, M Shivaprakash, A J Ullmann, J Maertens et al.
OBJECTIVES: Caspofungin was evaluated as first-line monotherapy of invasive aspergillosis (IA) in patients with haematological malignancies and undergoing autologous transplants. METHODS: Adults with proven or probable IA, defined strictly according to EORTC-MSG criteria, were eligible. Those with possible IA were enrolled, but were not evaluable for efficacy unless upgraded to proven/probable disease within 7 days of registration based on investigations performed within 48 h after enrolment...
December 2009: Journal of Antimicrobial Chemotherapy
Danielle Canioni, Gilles Salles, Nicolas Mounier, Nicole Brousse, Marie Keuppens, Frank Morchhauser, Thierry Lamy, Anne Sonet, Marie-Christine Rousselet, Charles Foussard, Luc Xerri
PURPOSE: High amounts of intratumoral macrophages have been shown to correlate with poor prognosis in patients with follicular lymphoma (FL) treated with chemotherapy without rituximab. We tried to establish whether intratumoral macrophage count (MC) definitely is able to predict the outcome of FL patients in the rituximab era. PATIENTS AND METHODS: We analyzed immunohistochemical CD68 expression in 194 FL patients from the FL-2000 trial, randomly assigned to receive cyclophosphamide, doxorubicin, etoposide, prednisolone, and interferon (CHVP-I) or rituximab plus CHVP-I...
January 20, 2008: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Hugues Malonne, Monte Coffiner, Bernard Sonet, Antoine Sereno, Francis Vanderbist
BACKGROUND: Opioid analgesics may be a useful alternative in patients with osteoarthritis who have not responded to first-line treatment with acetaminophen and in whom nonsteroidal anti-inflammatory drugs are contraindicated, ineffective, or poorly tolerated. OBJECTIVE: This study compared the efficacy and tolerability of tramadol LP 200 mg, a new once-daily,sustained-release formulation, with those of placebo in patients with osteoarthritis of the hip or knee. METHODS: In this multicenter, double-blind, placebo-controlled, parallel-group study, patients with osteoarthritis of the hip or knee (European League Against Rheumatism criteria) were randomized to receive either tramadol LP 200 mg once daily or placebo for 14 days...
November 2004: Clinical Therapeutics
N Mounier, C Gisselbrecht, J Brière, C Haioun, P Feugier, F Offner, C Recher, A Stamatoullas, F Morschhauser, M Macro, C Thieblemont, A Sonet, B Fabiani, F Reyes et al.
BACKGROUND: Data are still conflicting on the indication of front-line autologous stem-cell transplantation (ASCT) as consolidation for aggressive lymphoma. To assess the therapeutic effect of ASCT among different aggressive lymphoma subtypes, we conducted a matched-control analysis by pooling the data from two Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. PATIENTS AND METHODS: Between October 1987 and September 1998, 330 patients received ASCT after achieving complete remission with the ACBVP induction regimen...
December 2004: Annals of Oncology: Official Journal of the European Society for Medical Oncology
N Mounier, C Gisselbrecht, J Brière, C Haioun, P Feugier, F Offner, C Recher, A Stamatoullas, F Morschhauser, M Macro, C Thieblemont, A Sonet, B Fabiani, F Reyes et al.
PURPOSE: Improved survival has been observed in aggressive non-Hodgkin's lymphoma (NHL) patients with adverse prognostic factors when autotransplantation (ASCT) was performed after complete remission. However, there is no agreement on the prognostic factors for patients treated with ASCT. We aimed to estimate the prognostic effect of clinical and biologic variables on relapse and survival rates by pooling the data from two trials. PATIENTS AND METHODS: Of the patients treated in the LNH87 and LNH93 trials, 330 under age 60 years achieved complete remission after high-dose cyclophosphamide, doxorubicin, vincristine, and prednisone, and received consolidative ASCT; 16% of patients had T-cell NHL...
July 15, 2004: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
R Bouabdallah, N Mounier, C Guettier, T Molina, V Ribrag, C Thieblemont, A Sonet, A Delmer, K Belhadj, P Gaulard, C Gisselbrecht, L Xerri
PURPOSE: Because it is unclear whether T-cell/histiocyte-rich large B-cell lymphomas (H/TCRBCL) should be considered as a true clinicopathologic entity, we conducted a matched-control analysis comparing patients with H/TCRBCL and patients with diffuse large-B cell lymphoma (B-DLCL). PATIENTS AND METHODS: More than 4,500 patients were enrolled onto non-Hodgkin's lymphoma trials conducted by the Groupe d'Etude des Lymphomes de l'Adulte. After histologic review, 50 patients were subclassified as H/TCRBCL...
April 1, 2003: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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