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https://www.readbyqxmd.com/read/27904528/neuroprotective-effects-of-erythropoietin-against-oxidant-injury-following-brain-irradiation-an-experimental-study
#1
Gamze Ugurluer, Aysegul Cebi, Handan Mert, Nihat Mert, Meltem Serin, Haldun Sukru Erkal
INTRODUCTION: Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats. MATERIAL AND METHODS: Forty Wistar rats were randomly assigned to four groups (n = 10 each). In group 1 the rats received no EPO and underwent sham RT. The rats in groups 2 and 3 received EPO...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27896425/probability-and-pattern-of-occult-cervical-lymph-node-metastases-in-primary-parotid-carcinoma
#2
Dominik Stodulski, Bogusław Mikaszewski, Hanna Majewska, Piotr Wiśniewski, Czesław Stankiewicz
The present study was undertaken to evaluate real probability and pattern of cervical occult lymph node metastases (OLNM) in primary parotid carcinoma (PPC). We carried out a retrospective analysis of 66 patients treated in years 1992-2010 due to PPC, who underwent elective neck dissection (END). In search of risk factors for OLNM, we analysed the following parameters: age, sex, pT-Status, tumour size, skin invasion, facial nerve palsy, tumour fixation, extraparotid extension, localization, grade, histology, intra/periparotid LN metastases (IPLNM)...
November 28, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27892880/mri-cross-sectional-atlas-of-normal-canine-cervical-musculoskeletal-structure
#3
M Alizadeh, C Zindl, M J Allen, G G Knapik, N Fitzpatrick, W S Marras
Although magnetic resonance imaging (MRI) has been increasingly used as a diagnostic tool for cervical spine injuries in canines, a comprehensive normal MRI anatomy of the canine cervical spine muscles is lacking. Therefore, the purpose of this study was to build a magnetic resonance imaging atlas of the normal cross sectional anatomy of the muscles of the canine cervical spine. MRI scans were performed on a canine cadaver using a combination of T1 and T2-weighted images in the transverse, sagittal and dorsal planes acquired at a slice thickness of 1mm...
September 30, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27891299/tourette-syndrome-and-comorbid-neuropsychiatric-conditions
#4
REVIEW
Ashutosh Kumar, William Trescher, Debra Byler
Tourette syndrome is a neuropsychiatric condition characterized by both motor and phonic tics over a period of at least 1 year with the onset in childhood or adolescence. Apart from the tics, most of the patients with Tourette syndrome have associated neuropsychiatric comorbidities consisting of attention deficit hyperactivity disorder, obsessive compulsive disorder, rage attacks, sleep issues, depression, and migraine. Patients may also have physical complications directly from violent motor tics which can rarely include cervical myelopathy, arterial dissection, and stroke...
2016: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/27891029/craniovertebral-junction-360%C3%A2-a-combined-microscopic-and-endoscopic-anatomical-study
#5
Sukhdeep Singh Jhawar, Maximiliano Nunez, Paolo Pacca, Daniel Seclen Voscoboinik, Huy Truong
OBJECTIVES: Craniovertebral junction (CVJ) can be approached from various corridors depending on the location and extent of disease. A three-dimensional understanding of anatomy of CVJ is paramount for safe surgery in this region. Aim of this cadaveric study is to elucidate combined microscopic and endoscopic anatomy of critical neurovascular structures in this area in relation to bony and muscular landmarks. MATERIALS AND METHODS: Eight fresh-frozen cadaveric heads injected with color silicon were used for this study...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27889695/retrospective-observational-study-of-occult-cervical-lymph-node-metastasis-in-t1n0-tongue-cancer
#6
Takayuki Imai, Ikuro Satoh, Ko Matsumoto, Yukinori Asada, Tomoko Yamazaki, Shinkichi Morita, Satoshi Saijo, Jun-Ichi Okubo, Shun Wakamori, Shigeru Saijo, Kazuto Matsuura
OBJECTIVE: Delayed neck metastasis is the most significant prognostic factor for early tongue cancer. The main strategies for controlling cervical lymph nodes in Japan are elective neck dissection or watchful waiting. Elective neck dissection offers significantly better survival, but adversely impacts patient quality of life; consequently, here we investigated how to identify high-risk patients warranting elective neck dissection. METHODS: We retrospectively evaluated 67 patients with T1N0 oral tongue squamous cell carcinoma who underwent primary treatment in our department from April 2001 to March 2015...
November 25, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27884514/less-radical-surgery-for-early-stage-cervical-cancer-can-conization-specimens-help-identify-patients-at-low-risk-for-parametrial-involvement
#7
Blair Smith, Georgia A McCann, Gary Phillips, Floor J Backes, David M O'Malley, David E Cohn, Jeffrey M Fowler, Larry J Copeland, Ritu Salani
OBJECTIVE: Radical hysterectomy for cervical cancer is associated with increased morbidity over an extrafascial hysterectomy. The goal of this study was to determine incidence of and risk factors for parametrial involvement (PI) based on conization specimen (CS) and to potentially identify candidates for less radical surgery. METHODS: Patients with FIGO IA2-IIA cervical cancer treated with radical hysterectomy and pelvic lymph node dissection (RH) from 2000 to 2010 were retrospectively identified...
November 21, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27884458/risk-of-carotid-stroke-after-chiropractic-care-a-population-based-case-crossover-study
#8
J David Cassidy, Eleanor Boyle, Pierre Côté, Sheilah Hogg-Johnson, Susan J Bondy, Scott Haldeman
BACKGROUND: Chiropractic manipulation is a popular treatment for neck pain and headache, but may increase the risk of cervical artery dissection and stroke. Patients with carotid artery dissection can present with neck pain and/or headache before experiencing a stroke. These are common symptoms seen by both chiropractors and primary care physicians (PCPs). We aimed to assess the risk of carotid artery stroke after chiropractic care by comparing association between chiropractic and PCP visits and subsequent stroke...
November 21, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27882742/esophageal-adenocarcinoma-and-barrett-esophagus-in-a-neurologically-impaired-teenager
#9
Jae-Yeon Hwang, Yeoun Joo Lee, Peter Chun, Dong Hoon Shin, Jae Hong Park
Esophageal adenocarcinoma (EAC) accompanied by Barrett esophagus (BE) is rare in patients younger than 20 years old. EAC in the upper esophagus is also rare. We report a rare case of EAC with BE that developed in the upper esophagus after chronic, untreated gastroesophageal reflux disease in a neurologically impaired teenager. A 19-year-old neurologically impaired man underwent endoscopy for evaluation of dysphagia and vomiting, and was diagnosed with EAC with BE. He underwent transthoracic esophagectomy, extensive lymph node dissection, and cervical esophagogastric anastomosis, but the prognosis was poor...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27879313/international-registry-of-patients-carrying-tgfbr1-or-tgfbr2-mutations-results-of-the-montalcino-aortic-consortium
#10
Guillaume Jondeau, Jacques Ropers, Ellen Regalado, Alan Braverman, Arturo Evangelista, Guisela Teixido, Julie De Backer, Laura Muiño-Mosquera, Sophie Naudion, Cecile Zordan, Takayuki Morisaki, Hiroto Morisaki, Yskert Von Kodolitsch, Sophie Dupuis-Girod, Shaine A Morris, Richmond Jeremy, Sylvie Odent, Lesley C Adès, Madhura Bakshi, Katherine Holman, Scott LeMaire, Olivier Milleron, Maud Langeois, Myrtille Spentchian, Melodie Aubart, Catherine Boileau, Reed Pyeritz, Dianna M Milewicz
BACKGROUND: -The natural history of aortic diseases in patients with TGFBR1 or TGFBR2 mutations reported by different investigators has varied greatly. In particular, the current recommendations for the timing of surgical repair of the aortic root aneurysms may be overly aggressive. METHODS AND RESULTS: -The Montalcino Aortic Consortium, which includes 15 centers worldwide that specialize in heritable thoracic aortic diseases, was used to gather data on 441 patients from 228 families, with 176 cases harboring a mutation in TGBR1 and 265 in TGFBR2 Patients harboring a TGFBR1 mutation have similar survival rates (80% survival at 60 years), aortic risk (23% aortic dissection, 18% preventive aortic surgery), and prevalence of extra-aortic features (29% hypertelorism, 53% cervical arterial tortuosity, 27% wide scars) when compared to patients harboring a TGFBR2 mutation...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27876132/possible-role-of-intronic-polymorphisms-in-the-phactr1-gene-on-the-development-of-cardiovascular-disease
#11
José Manuel Rodríguez-Pérez, Ruben Blachman-Braun, Alan Pomerantz, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández
Cardiovascular disease (CVD) is a complex multifactorial and polygenetic disease in which the interaction of numerous genes, genetic variants, and environmental factors plays a major role in its development. In an attempt to demonstrate the association between certain genetic variants and CVD, researchers have run large genomic wild association studies (GWAS) in recent decades. These studies have correlated several genomic variants with the presence of CVD. Recently, certain polymorphisms in the phosphatase and actin regulator 1 (PHACTR1) gene have been shown to be associated with CVD (i...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27868440/-maximizing-nodal-yield-while-minimizing-surgical-morbidity-the-appropriate-neck-dissection
#12
István Háromi, Imre Gerlinger, László Lujber, Balázs Bendegúz Lőrincz
Cervical regional lymphadenectomy, also known as neck dissection, is a fundamental procedure in head and neck surgery. Its evolution over 110 years resulted in a great deal of confusion in the literature and in clinical practice, due to the heterogenicity in training, classification and surgical techniques, which makes outcomes comparability virtually impossible. The authors aim to clarify this situation in a structured manner, in order to facilitate communication among all specialists involved in multidisciplinary head and neck cancer care...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27867869/thyroid-langerhans-cell-histiocytosis-and-papillary-thyroid-carcinoma
#13
Rajab AlZahrani, Mohammed Algarni, Hadi Alhakami, Haia AlSubayea, Naif Alfattani, Mohammet Guler, Mohamed Satti
A 27-year-old female, married with two children, presented to our clinic with a 1-year history of thyroid swelling and pressure symptoms on lying backward and bilateral cervical lymphadenopathy. The patient was a known case of panhypopituitarism for 5 years. Comprehensive patient evaluation including FNAC with papillary thyroid cancer result then she underwent total thyroidectomy and bilateral neck dissection and final histologic examination confirmed papillary thyroid carcinoma in the background of lymphocytic thyroiditis, associated with Langerhans cell histiocytosis (LCH)...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27867579/three-field-lymph-node-dissection-in-treating-the-esophageal-cancer
#14
REVIEW
Qi-Xin Shang, Long-Qi Chen, Wei-Peng Hu, Han-Yu Deng, Yong Yuan, Jie Cai
There are many controversies in lymphadenectomy for thoracic esophageal cancer, and whether 3-field lymphadenectomy or 2-field lymphadenectomy is better have still been in doubt. The aim of this article is to review the role of the lymph node dissection by introducing the merits and demerits in 3-field lymphadenectomy, and the development in lymphadenectomy's selection, treatment and diagnosis. All the literatures related to esophageal lymphadenectomy and minimally invasive surgery (MIE) were searched in PubMed database and the cross references were added and reviewed to complete the reference list...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27855383/clinical-aspects-and-prognostic-factors-for-survival-in-patients-with-recurrent-cervical-cancer-after-radical-hysterectomy
#15
Jitti Hanprasertpong, Ingporn Jiamset, Alan Geater, Athithan Rattanaburi, Sarayut Thannil
BACKGROUND: The aim of this study was to investigate the clinical aspects and prognostic factors for survival in patients with recurrent cervical cancer after radical hysterectomy with node dissection (RHND) for stages IA2-IB1. PATIENTS AND METHODS: Clinicopathologic characteristics of the primary tumor, pattern of recurrence, method of detection, salvage treatment, and outcome were reviewed from the medical records of patients who underwent RHND between 1987 and 2015...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27854110/association-between-carotid-artery-tortuosity-and-carotid-dissection-a-case-control-study
#16
Sarasa T Kim, Waleed Brinjikji, Vance T Lehman, Carrie M Carr, Patrick H Luetmer, Charlotte H Rydberg
BACKGROUND: Carotid artery dissections have long been associated with compromise of the structural integrity of the arterial wall from heritable connective-tissue disorders, hypertension, and trauma. However, an association between spontaneous internal carotid artery dissection and tortuous or redundant carotid anatomy has not been fully explored. METHODS: Patients with CTA confirmed spontaneous cervical internal carotid artery dissections were compared to a group of age and sex matched controls who also received CTA of the neck...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27852529/seasonal-variation-in-cervical-artery-dissection-in-the-hunter-new-england-region-new-south-wales-australia-a-retrospective-cohort-study
#17
Lucy C Thomas, Andrew P Makaroff, Chris Oldmeadow, John R Attia, Christopher R Levi
BACKGROUND: Cervical artery dissection (CAD) is a leading cause of ischemic stroke among middle aged adults, yet the aetiology remains poorly understood. There are reports from colder northern hemisphere sites of a seasonal pattern in the incidence of CAD. Seasonality may suggest some transient putative pro-inflammatory mechanism but it is unknown whether this also exists in temperate climates. AIMS: To investigate the seasonal variation in incidence of CAD in the xx Region, Australia, and to compare seasonal incidence and selected clinical features between cases of carotid and vertebral artery dissection...
October 20, 2016: Manual Therapy
https://www.readbyqxmd.com/read/27849338/neck-dissections-emerging-role-of-oral-pathologists
#18
Madhusudan Astekar, Amolika Choube, Gaurav Sapra, Rajesh Kumar Chitlangiya
BACKGROUND: Surgical resection has been the principle treatment approach for early lesions as well as advanced stage carcinomas of upper aero digestive tract. Neck dissection is the primary treatment given to nodal metastasis of oral carcinomas. Choice of irradiation and chemotherapy post surgery relies heavily on the histopathological assessment of surgical margins of resected tumor, dissected lymph nodes and accessory tissues. METHODS: A total of ten cases of head and neck carcinomas reported in two years period were analyzed...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27847078/successful-treatment-of-esophageal-necrosis-secondary-to-acute-type-b-aortic-dissection
#19
Kyla D Joubert, Richard D Betzold, Matthew A Steliga
Esophageal necrosis after descending aortic dissection has been described but with no reports of successful treatment. A 66-year-old man with aortic dissection extending from the left subclavian artery through the common iliac arteries subsequently experienced esophageal necrosis. He underwent thoracic esophagectomy, cervical end esophagostomy, and open gastrostomy tube placement. Gastrointestinal continuity was established with a gastric tube conduit in the substernal plane. An oral diet was tolerated after reconstruction...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27843810/braf-v600e-mutation-has-it-a-role-in-cervical-lymph-node-metastasis-of-papillary-thyroid-cancer
#20
Neslihan Kurtulmus, Burak Ertas, Yesim Saglican, Hakan Kaya, Umit Ince, Mete Duren
BACKGROUND: The BRAF(V600E) mutation is common in papillary thyroid cancer (PTC). Lymph node metastasis (LNM) may be associated with poor prognosis. However, the LNM mechanism remains unclear. OBJECTIVES: Our aim was to evaluate the prevalence of the BRAF(V600E) mutation in primary tumors and accompanying LNM at the time of diagnosis. METHODS: This retrospective study included 51 PTC patients (40 women, 11 men; mean age 40.0 ± 16.5 years; range 6-81) who underwent total thyroidectomy accompanied by a lateral neck dissection due to preoperatively detected LNM...
September 2016: European Thyroid Journal
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