Adrián Vega-Pérez, Laura H Villarrubia, Cristina Godio, Alejandra Gutiérrez-González, Lidia Feo-Lucas, Margarita Ferriz, Natalia Martínez-Puente, Julieta Alcaín, Alfonso Mora, Guadalupe Sabio, María López-Bravo, Carlos Ardavín
Peritoneal immune cells reside unanchored within the peritoneal fluid in homeostasis. Here, we examined the mechanisms that control bacterial infection in the peritoneum using a mouse model of abdominal sepsis following intraperitoneal Escherichia coli infection. Whole-mount immunofluorescence and confocal microscopy of the peritoneal wall and omentum revealed that large peritoneal macrophages (LPMs) rapidly cleared bacteria and adhered to the mesothelium, forming multilayered cellular aggregates composed by sequentially recruited LPMs, B1 cells, neutrophils, and monocyte-derived cells (moCs)...
November 9, 2021: Immunity