Viviana Cortiana, Harshal Chorya, Muskan Joshi, Shreevikaa Kannan, Diksha Mahendru, Harshitha Vallabhaneni, Helena S Coloma, Yan Leyfman, Chandler H Park
This paper provides insights into the conventional understanding of biliary tract malignancies, with a specific focus on cholangiocarcinoma (CCA). We then delve into the groundbreaking ideas presented by Dr. James Cleary. CCA, originating from biliary tree cells, manifests diverse subtypes contingent upon anatomical localization and differentiation status. These variants exhibit discrete genetic aberrations, yielding disparate clinical phenotypes and therapeutic modalities. Intrahepatic, perihilar, and distal CCAs intricately involve distinct segments of the biliary tree, further categorized as well-differentiated, moderately differentiated, or poorly differentiated adenocarcinomas based on their histological differentiation...
February 1, 2024: Cancers