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Prostate sbrt

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https://www.readbyqxmd.com/read/28086825/toxicity-and-quality-of-life-report-of-a-phase-ii-study-of-stereotactic-body-radiotherapy-sbrt-for-low-and-intermediate-risk-prostate-cancer
#1
Matthew J Boyer, Michael A Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu, W Robert Lee
BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion management and daily plan re-optimization for low to intermediate risk prostate cancer was undertaken to evaluate this hypothesis. This report details the toxicity and quality of life following treatment. METHODS: From 2009 to 2013, 60 patients with T1-T2c prostate cancer with a Gleason score of 6 and PSA ≤ 15 or Gleason score of 7 and PSA ≤ 10 were enrolled...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28073637/variable-angle-stereo-imaging-for-rapid-patient-position-correction-in-an-in-house-real-time-position-monitoring-system
#2
Sankar Arumugam, Mark Sidhom, Daniel Truant, Aitang Xing, Mark Udovitch, Lois Holloway
PURPOSE: To develop and validate a variable angle stereo image based position correction methodology in an X-ray based in-house online position monitoring system. MATERIALS AND METHODS: A stereo imaging module that enables 3D position determination and couch correction of the patient based on images acquired at any arbitrary angle and arbitrary angular separation was developed and incorporated to the in-house SeedTracker real-time position monitoring system. The accuracy of the developed system was studied by imaging an anthropomorphic phantom implanted with radiopaque markers set to known offset positions from its reference position in an Elekta linear accelerator (LA) and associated XVI imaging system...
January 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28048809/mo-d-brc-01-memorial-lecture
#3
B Fraass
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048786/mo-d-brc-04-multiple-criteria-optimization-planning
#4
J Donaghue
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048666/su-f-t-312-identifying-distinct-radiation-therapy-plan-classes-through-multi-dimensional-analysis-of-plan-complexity-metrics
#5
V Desai, Z Labby, W Culberson
PURPOSE: To determine whether body site-specific treatment plans form unique "plan class" clusters in a multi-dimensional analysis of plan complexity metrics such that a single beam quality correction determined for a representative plan could be universally applied within the "plan class", thereby increasing the dosimetric accuracy of a detector's response within a subset of similarly modulated nonstandard deliveries. METHODS: We collected 95 clinical volumetric modulated arc therapy (VMAT) plans from four body sites (brain, lung, prostate, and spine)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048661/su-f-t-277-using-dose-weighted-mean-effective-depth-to-improve-accuracy-of-secondary-mu-calculation-for-vmat-plans
#6
H Qu, N Yu, P Qi, A Godley, P Xia
PURPOSE: In commercial secondary dose calculation system, an average effective depth is used to calculate the Monitor Units for an arc beam from the volumetric modulated arc (VMAT) plans. Typically, an arithmetic mean of the effective depths (AMED) of a VMAT arc beam is used, which may result in large MU discrepancy from that of the primary treatment planning system. This study is to demonstrate the use of a dose weighted mean effective depth (DWED) can improve accuracy of MU calculation for the secondary MU verification...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048471/su-g-jep3-03-effect-of-robot-pose-on-beam-blocking-for-ultrasound-guided-sbrt-of-the-prostate
#7
S Gerlach, I Kuhlemann, F Ernst, C Fuerweger, A Schlaefer
PURPOSE: Ultrasound presents a fast, volumetric image modality for real-time tracking of abdominal organ motion. How-ever, ultrasound transducer placement during radiation therapy is challenging. Recently, approaches using robotic arms for intra-treatment ultrasound imaging have been proposed. Good and reliable imaging requires placing the transducer close to the PTV. We studied the effect of a seven degrees of freedom robot on the fea-sible beam directions. METHODS: For five CyberKnife prostate treatment plans we established viewports for the transducer, i...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048402/su-f-t-569-implementation-of-a-patient-specific-qa-method-using-ebt-xd-for-cyberknife-srs-sbrt-plans
#8
K Zerouali, J Aubry, R Doucet
PURPOSE: To implement the new EBT-XD Gafchromic films for accurate dosimetric and geometric validation of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) CyberKnife (CK) patient specific QA. METHODS: Film calibration was performed using a triplechannel film analysis on an Epson 10000XL scanner. Calibration films were irradiated using a Varian Clinac 21EX flattened beam (0 to 20 Gy), to ensure sufficient dose homogeneity. Films were scanned to a resolution of 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048209/su-f-p-55-testicular-scatter-dose-determination-during-prostate-sbrt-with-and-without-pelvic-lymph-nodes
#9
C Venencia, A Germanier, E Garrigo, P Castro Pena, J Torres, S Zunino
PURPOSE: The elective irradiation of pelvis lymph node for prostate cancer is still controversial. Including pelvic lymph node as part of the planning target volume could increase the testicular scatter dose, which could have a clinical impact. The objective of this work was to measure testicular scatter dose for prostate SBRT treatment with and without pelvic lymph nodes using TLD dosimetry. METHODS: A 6MV beam (1000UM/min) produce by a Novalis TX (BrainLAB-VARIAN) equipped HDMLC was used...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048157/mo-d-brc-02-auto-planning
#10
P Xia
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047880/su-f-t-328-real-time-in-vivo-dosimetry-of-prostate-sbrt-boost-treatments-using-moskin-detectors
#11
K Legge, D Cutajar, A Wilfert, J Martin, A Rozenfeld, D J O'Connor, P Greer
PURPOSE: To provide in vivo measurements of dose to the anterior rectal wall during prostate SBRT boost treatments using MOSFET detectors. METHODS: Dual MOSkin detectors were attached to a Rectafix rectal sparing device and inserted into patients during SBRT boost treatments. Patients received two boost fractions, each of 9.5-10 Gy and delivered using 2 VMAT arcs. Measurements were acquired for 12 patients. MOSFET voltages were read out at 1 Hz during delivery and converted to dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047620/th-cd-207a-12-impacts-of-inter-and-intra-fractional-organ-motion-for-high-risk-prostate-cancer-stereotactic-body-radiation-therapy
#12
N Hassan Rezaeian, Y Chi, Y Zhou, Z Tian, S Jiang, R Hannan, X Jia
PURPOSE: We are conducting a clinical trial on stereotactic body radiation therapy (SBRT) for high-risk prostate cancer. Doses to three targets, prostate, intra-prostatic lesion, and pelvic lymph node (PLN) region, are escalated to three different levels via simultaneous integrated boost technique. Inter-/intra-fractional organ motions deteriorate planned dose distribution. This study aims at developing a dose reconstruction system to comprehensively understand the impacts of organ motion in our clinical trial...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047505/mo-d-brc-03-knowledge-based-planning
#13
Q Wu
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047493/su-f-t-625-optimal-treatment-planning-strategy-among-arc-arrangements-for-prostate-sbrt-with-vmat-technique
#14
J Chung, S Kang, T Suh, J Lee, J Kim, K Eom
PURPOSE: The purpose of this study is to determine the optimal treatment planning strategy among the different arc arrangements for prostate stereotactic body radiotherapy (SBRT) plans with volumetric modulated arc therapy (VMAT). METHODS: Ten patients with prostate cancer were selected. The SBRT-VMAT plans for each patient were generated with single-full (181° to 179°; 1FA), single-partial (240° to 120°; 1PA), double-full (181° to 179° and 179° to 181°; 2FA), and double-partial (240° to 120° and 120° to 240°; 2PA) arc arrangements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047452/su-g-jep4-10-measurement-of-prostate-motion-trajectories-during-prostate-sbrt-boost-treatments-with-a-rectafix
#15
K Legge, D Nguyen, J Ng, L Wilton, J Booth, P Keall, J Martin, D J O'Connor, P Greer
PURPOSE: To determine prostate motion during SBRT boost treatments with a Rectafix rectal sparing device in place using kV imaging during treatment. METHODS: Patients each had three gold fiducial markers inserted into the prostate and received two VMAT boost fractions of 9.5-10 Gy under the PROMETHEUS clinical trial protocol with a Rectafix rectal retractor in place. Two-dimensional kilovoltage images of fiducial markers were acquired continuously during delivery...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047320/mo-fg-bra-07-intrafractional-motion-effect-can-be-minimized-in-tomotherapy-stereotactic-body-radiotherapy-sbrt
#16
A Price, E Chao, S Chang, J Matney, A Wang, J Lian
PURPOSE: Tomotherapy has unique challenges in handling intrafractional motion compared to conventional LINAC. In this study, we analyzed the impact of intrafractional motion on cumulative dosimetry using actual patient motion data and investigated real time jaw/MLC compensation approaches to minimize the motion-induced dose discrepancy in Tomotherapy SBRT treatment. METHODS: Intrafractional motion data recorded in two CyberKnife lung treatment cases through fiducial tracking and two LINAC prostate cases through Calypso tracking were used in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047312/su-f-t-268-a-feasibility-study-of-independent-dose-verification-for-vero4drt
#17
M Yamashita, R Takahashi, M Kokubo, K Takayama, H Tanabe, M Sueoka, M Ishii, N Okuuchi, Y Iwamoto, H Tachibana
PURPOSE: Vero4DRT (Mitsubishi Heavy Industries Ltd.) has been released for a few years. The treatment planning system (TPS) of Vero4DRT is dedicated, so the measurement is the only method of dose verification. There have been no reports of independent dose verification using Clarksonbased algorithm for Vero4DRT. An independent dose verification software program of the general-purpose linac using a modified Clarkson-based algorithm was modified for Vero4DRT. In this study, we evaluated the accuracy of independent dose verification program and the feasibility of the secondary check for Vero4DRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047214/su-f-t-260-using-portal-image-device-for-pre-treatment-qa-in-volumetric-modulated-arc-plans-with-flattening-filter-free-fff-beams
#18
H Qu, P Qi, N Yu, P Xia
PURPOSE: To implement and validate a method of using electronic portal image device (EPID) for pre-treatment quality assurance (QA) of volumetric modulated arc therapy (VMAT) plans using flattering filter free (FFF) beams for stereotactic body radiotherapy (SBRT). METHODS: On Varian Edge with 6MV FFF beam, open field (from 2×2 cm to 20×20 cm) EPID images were acquired with 200 monitor unit (MU) at the image device to radiation source distance of 150cm. With 10×10 open field and calibration unit (CU) provided by vendor to EPID image pixel, a dose conversion factor was determined by dividing the center dose calculated from the treatment planning system (TPS) to the corresponding CU readout on the image...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047178/th-ab-202-12-the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-tracking-system-during-radiation-therapy
#19
D Nguyen, J Kim, R O'Brien, C Huang, J Booth, P Greer, K Legge, P Poulsen, J Martin, P Keall
PURPOSE: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. METHODS: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047145/su-f-t-365-clinical-commissioning-of-the-monaco-treatment-planning-system-for-the-novalis-tx-to-deliver-vmat-srs-and-sbrt-treatments
#20
N Adnani
PURPOSE: To commission the Monaco Treatment Planning System for the Novalis Tx machine. METHODS: The commissioning of Monte-Carlo (MC), Collapsed Cone (CC) and electron Monte-Carlo (eMC) beam models was performed through a series of measurements and calculations in medium and in water. In medium measurements relied Octavius 4D QA system with the 1000 SRS detector array for field sizes less than 4 cm × 4 cm and the 1500 detector array for larger field sizes. Heterogeneity corrections were validated using a custom built phantom...
June 2016: Medical Physics
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