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Cervical cancer brachytherapy

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https://www.readbyqxmd.com/read/29145247/comparison-of-chemoradiotherapy-with-and-without-brachytherapy-as-adjuvant-therapy-after-radical-surgery-in-early-stage-cervical-cancer-with-poor-prognostic-factors-an-observational-study
#1
Mei-Ling Lan, Xian Yu, He Xiao, Peng Zhou, Nan Hu, Yun Liu, Ge Wang
This study aimed to determine whether the addition of intracavitary brachytherapy (ICBT) to chemoradiotherapy (CRT) improves outcome in patients with cervical cancer and poor prognostic factors. Patients with stage IB to IIA cervical cancer who had undergone radical hysterectomy and pelvic lymphadenectomy between August 2008 and December 2014 were retrospectively registered in this study. All patients received external beam radiation therapy (EBRT) + chemotherapy, and some patients additionally received ICBT...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29128230/clinical-outcomes-using-image-guided-interstitial-brachytherapy-for-definitive-cervical-cancer-patients-with-high-risk-clinical-target-volumes-greater-than-30%C3%A2-cc
#2
Chenyang Wang, Jagdeep Raince, Uma Swamy, Sang-June Park, Lalaine Zaide, Shane Mesko, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and toxicity outcomes are acceptable. METHODS: A retrospective review of 37 cervical cancer patients with high-risk clinical target volumes (HR-CTVs) ≥30 cc treated with interstitial image-guided brachytherapy (IS IGBT) was performed...
November 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29118704/spontaneous-remission-of-severe-systemic-langerhans-cell-histiocytosis-with-bladder-involvement-a-case-study
#3
Isotta M Magaton, Alexandar Tzankov, Fatime Krasniqi, Christof Rottenburger, Rosanna Zanetti-Daellenbach, Peter Grendelmeier, Viola Heinzelmann-Schwarz, Michael Mayr, Fabienne D Schwab
Background: The clinical presentation of Langerhans cell histiocytosis (LCH) is heterogeneous ranging from single-organ involvement to systemic disease causing substantial morbidity and mortality. We describe an unusual course of severe multisystem LCH with spontaneous remission. Case Presentation: We report on a 45-year-old Caucasian woman with cervical cancer, FIGO stage IVB. Five months after the end of combined radiochemotherapy and brachytherapy, the patient was readmitted because of severe dysuria...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29110878/tumour-size-volume-and-marker-expression-during-radiation-therapy-can-predict-survival-of-cervical-cancer-patients-a-multi-institutional-retrospective-analysis-of-krog-16-01
#4
Jong Hoon Lee, Sea-Won Lee, Ju Ree Kim, Yeon Sil Kim, Mee Sun Yoon, Songmi Jeong, Jin Hee Kim, Ja Young Lee, Keun Yong Eom, Bae Kwon Jeong, Seok Ho Lee
OBJECTIVE: The aim of this multi-institutional study was to determine the prognostic impact of tumour parameters, such as tumour size (TS), tumour volume (TV), and marker expression, on survival during radiation therapy (RT) for cervical cancer patients. METHODS: A total of 231 patients with histologically confirmed cervical cancer, classified as Federation of Gynecology and Obstetrics (FIGO) Ib2-IVa, were enrolled in this study. Pre- and mid-RT pelvic magnetic resonance imaging (MRI) and squamous cell carcinoma antigen (SCC-ag) analysis were performed twice, during RT and just before brachytherapy...
October 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#5
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29097137/3t-multiparametric-mri-guided-high-dose-rate-combined-intracavitary-and-interstitial-adaptive-brachytherapy-for-the-treatment-of-cervical-cancer-with-a-novel-split-ring-applicator
#6
Elisha Fredman, Bryan Traughber, Tarun Podder, Valdir Colussi, Yiran Zheng, Suzanne Russo, Karin Herrmann, Raj Paspulati, Steven Waggoner, Kristin Zanotti, Christa Nagel, John Nakayama, Mitchell Machtay, Rodney Ellis
PURPOSE: To evaluate the role of 3T-MRI-guided adaptive high-dose-rate (HDR) combined intracavitary and interstitial brachytherapy for cervical cancer using a novel intracavitary split-ring (ICSR) applicator adapter. METHODS AND MATERIALS: We retrospectively reviewed all HDR brachytherapy cases from 2013 to 2015 using an ICSR applicator. Initial optimization was performed using 3T multiparametric MRI (mpMRI) series with an applicator in place. The mpMRI series were discretionarily acquired before subsequent fractions for possible target adaptation...
October 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29079120/evaluation-of-delivery-costs-for-external-beam-radiation-therapy-and-brachytherapy-for-locally-advanced-cervical-cancer-using-time-driven-activity-based-costing
#7
Kristine Bauer-Nilsen, Colin Hill, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery costs, using time-driven activity-based costing, and reimbursement for definitive radiation therapy for locally advanced cervical cancer. METHODS AND MATERIALS: Process maps were created to represent each step of the radiation treatment process and included personnel, equipment, and consumable supplies used to deliver care. Personnel were interviewed to estimate time involved to deliver care. Salary data, equipment purchasing information, and facilities costs were also obtained...
September 14, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29066085/delineating-the-relationship-between-point-a-prescription-dose-and-pelvic-lymph-node-doses-in-intracavitary-high-dose-rate-brachytherapy-treatment-of-cervical-cancer-for-use-in-low-and-middle-income-countries
#8
John Weaver, Grant Harmon, Matthew M Harkenrider, Murat Surucu, Abbie Wood, Fiori Alite, William Small
PURPOSE: To define the relationship between the Point A prescription dose and the dose delivered to various pelvic lymph node groups during high-dose-rate (HDR) brachytherapy treatment of cervical cancer. In less developed countries, brachytherapy is often done without three-dimensional image guidance, instead relying on plain radiography and prescription to Point A. A defined relationship between Point A dose and lymph node doses would help physicians in these health care settings to more accurately estimate nodal doses...
October 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29060966/-clinical-study-of-intensity-modulated-radiotherapy-and-three-dimensional-conformal-radiotherapy-with-three-dimensional-brachytherapy-and-concurrent-chemotherapy-for-patients-with-advanced-cervical-cancer
#9
COMPARATIVE STUDY
X X Du, H Yang, H J Zhang, L A Li, W S Fan, Y G Meng
Objective: To compare the dose, clinical efficacy and acute adverse reactions of intensity modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) combined with three-dimensional brachytherapy (3D-BT) in the treatment of concurrent radiotherapy and chemotherapy for advanced stage cervical cancer patients. Methods: Data collection was performed from January 2011 to November 2015 in Chinese PLA General Hospital and Inner Mongolia Cancer Hospital. All 89 patients with advanced stage (Ⅱ b-Ⅲ b) cervical cancer were treated by pelvic radiotherapy and concurrent chemotherapy, 46 cases of them received IMRT and 3D-BT (IMRT group) , 43 cases received 3D-CRT and 3D-BT (3D-CRT group) , along with cisplatin chemotherapy...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29055558/pelvic-fractures-after-definitive-and-postoperative-radiotherapy-for-cervical-cancer-a-retrospective-analysis-of-risk-factors
#10
Kasumi Yamamoto, Shoji Nagao, Kazuhiro Suzuki, Ai Kogiku, Tokihiro Senda, Hiroko Yano, Miho Kitai, Takaya Shiozaki, Kazuko Matsuoka, Satoshi Yamaguchi
OBJECTIVES: This study clarified the incidence of and identified the risk factors for post-radiation pelvic insufficiency fractures (PIFs) in women who received postoperative definitive or adjuvant radiotherapy (RT) for cervical cancer. PATIENTS AND METHODS: The medical records and data of imaging studies, including computed tomography scan and magnetic resonance imaging, of women with cervical cancer who received external-beam RT for the entire pelvic area between January 2003 and December 2012 at our institution were reviewed...
October 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#11
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#12
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28984277/a-multicentre-audit-of-hdr-pdr-brachytherapy-absolute-dosimetry-in-association-with-the-interlace-trial-nct015662405
#13
Patricia Diez, Edwin G A Aird, Thorsten Sander, Clare A Gouldstone, Peter H G Sharpe, Christopher D Lee, Gerry Lowe, Russell A S Thomas, Tania Simnor, Peter Bownes, A Margaret Bidmead, Laura Gandon, David J Eaton, Antony L Palmer
A UK multicentre audit to evaluate HDR and PDR brachytherapy has been performed using alanine absolute dosimetry. This is the first national UK audit performing an absolute dose measurement at a clinically relevant distance (20 mm) from the source. It was performed in both INTERLACE (a phase III multicentre trial in cervical cancer) and non-INTERLACE brachytherapy centres treating gynaecological tumours. Forty-seven UK centres (including the National Physical Laboratory) were visited. A simulated line source was generated within each centre's treatment planning system and dwell times calculated to deliver 10 Gy at 20 mm from the midpoint of the central dwell (representative of Point A of the Manchester system)...
October 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28975498/factors-associated-with-changes-in-vaginal-length-and-diameter-during-pelvic-radiotherapy-for-cervical-cancer
#14
Jumara Martins, Ana Francisca Vaz, Regina Celia Grion, Sérgio Carlos Barros Esteves, Lúcia Costa-Paiva, Luiz Francisco Baccaro
OBJECTIVES: This study reports the incidence and factors associated with vaginal stenosis and changes in vaginal dimensions after pelvic radiotherapy for cervical cancer. METHODS: A descriptive longitudinal study with 139 women with cervical cancer was conducted from January 2013 to November 2015. The outcome variables were vaginal stenosis assessed using the Common Terminology Criteria for Adverse Events (CTCAE v3.0) and changes in vaginal diameter and length after the end of radiotherapy...
October 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28959365/intensity-modulated-radiotherapy-combined-with-iodine-125-seed-implantation-in-non-central-recurrence-of-cervical-cancer-a-case-report-and-literature-review
#15
Hu Feng, Yuanyuan Hu, Peng Jin, Xiangkuan Meng, Yubing Chen, Hongmei Zhang
Recurrent cervical cancer is a clinically complex disease that is difficult to treat. There are numerous treatment options, but the results achieved by each are poor. External-beam radiation therapy of the pelvic lymph drainage area, in combination with intracavitary afterloading or the interstitial implantation of a radiation source (i.e., brachytherapy), are the current standard radiotherapy regimens used in high-risk clinical targets. However, there are few reports concerning the use of iodine-125 ((125)I) seed implantation brachytherapy in recurrent cervical cancer, and the effects of treatment and adverse reactions have not yet been systematically evaluated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28951755/automated-calculation-of-point-a-coordinates-for-ct-based-high-dose-rate-brachytherapy-of-cervical-cancer
#16
Hyejoo Kang, Laura Padilla, Yasmin Hasan, Hania Al-Hallaq
PURPOSE: The goal is to develop a stand-alone application, which automatically and consistently computes the coordinates of the dose calculation point recommended by the American Brachytherapy Society (i.e., point A) based solely on the implanted applicator geometry for cervical cancer brachytherapy. MATERIAL AND METHODS: The application calculates point A coordinates from the source dwell geometries in the computed tomography (CT) scans, and outputs the 3D coordinates in the left and right directions...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28951754/assessing-dose-contribution-to-pelvic-lymph-nodes-in-intracavitary-brachytherapy-for-cervical-cancer
#17
Gail Wan Ying Chua, Yong Wee Foo, Guan Heng Tay, David Boon Harn Tan
PURPOSE: In radical radiotherapy for cervical cancer, high-dose-rate (HDR) brachytherapy is commonly used after external beam radiation therapy (EBRT) to deliver a cumulative EQD2 of 80 to 90 Gy to the primary tumor. However, there is less certainty regarding brachytherapy dose contribution to the pelvic lymph nodes. This poses a challenge as to how high a preceding EBRT dose should be prescribed to gross nodal disease, in order to achieve a cumulative tumoricidal effect. Hence, this study aims to quantify brachytherapy dose contribution to individual pelvic nodal groups, using computed tomography (CT) planning with the Manchester system...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28948205/cervical-cancer-in-low-and-middle-income-countries-addressing-barriers-to-radiotherapy-delivery
#18
REVIEW
Anna W LaVigne, Scott A Triedman, Thomas C Randall, Edward L Trimble, Akila N Viswanathan
The global cervical cancer burden falls disproportionately upon women in low and middle-income countries. Insufficient infrastructure, lack of access to preventive HPV vaccines, screening, and treatment, as well as limited trained personnel and training opportunities, continue to impede efforts to reduce incidence and mortality in these nations. These hurdles have been substantial challenges to radiation delivery in particular, preventing treatment for a disease in which radiation is a cornerstone of curative therapy...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28940520/direction-modulated-brachytherapy-dmbt-for-treatment-of-cervical-cancer-a-planning-study-with-192ir-60co-and-169yb-hdr-sources
#19
Habib Safigholi, Dae Yup Han, Shahram Mashouf, Abraam Soliman, Ali S Meigooni, Amir Owrangi, William Y Song
PURPOSE: To evaluate plan quality of a novel MRI-compatible direction modulated brachytherapy (DMBT) tandem applicator using 192Ir, 60Co, and 169Yb HDR brachytherapy sources, for various cervical cancer high-risk clinical target volumes (CTVHR ). MATERIALS AND METHODS: The novel DMBT tandem applicator has six peripheral grooves of 1.3-mm diameter along a 5.4-mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of the 192Ir, 60Co, and 169Yb HDR sources in a water phantom against the literature data...
September 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28935271/magnetic-resonance-imaging-during-definitive-chemoradiotherapy-can-predict-tumor-recurrence-and-patient-survival-in-locally-advanced-cervical-cancer-a-multi-institutional-retrospective-analysis-of-krog-16-01
#20
MULTICENTER STUDY
Sea-Won Lee, Seok Ho Lee, Juree Kim, Yeon-Sil Kim, Mee Sun Yoon, Songmi Jeong, Jin Hee Kim, Jayoung Lee, Keun-Yong Eom, Bae Kwon Jeong, Soo Yoon Sung, Sung Jong Lee, Jong Hoon Lee
OBJECTIVE: Definitive chemoradiotherapy (CRT) followed by brachytherapy is a standard treatment for locally advanced cervical cancer. During CRT, marked reduction of cervical tumor is often observed in magnetic resonance imaging (MRI). The primary aim of this study was to assess the association between tumor response in MRI using FIGO classification and clinical outcomes. METHODS: Multi-institutional data were retrospectively reviewed to identify the significance of MR tumor response on tumor recurrence and patient survival...
November 2017: Gynecologic Oncology
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