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Cervical cancer brachytherapy

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https://www.readbyqxmd.com/read/28633094/impact-of-management-on-mortality-in-patients-with-invasive-cervical-cancer-in-reunion-island
#1
Phuong Lien Tran, Philippe Morice, Emmanuel Chirpaz, Glorianne Lazaro, Malik Boukerrou
OBJECTIVE: In Reunion Island, the standardized mortality rate for cervical cancer is 4.8/100,000 women, twice higher than in Metropolitan France. For locally advanced disease, the standard of care includes a treatment by brachytherapy. Nevertheless, brachytherapy was not available on the Island before 2016. The objective of this study was to assess the impact of the management of patients with invasive cervical cancer on mortality in Reunion. METHODS: We have identified all the women hospitalized in one of the health care centers of the Island diagnosed with invasive cervical cancer between 01/01/2010 and 31/12/2015...
June 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28619385/rectum-and-bladder-spacing-in-cervical-cancer-brachytherapy-using-a-novel-injectable-hydrogel-compound-traceit
#2
Antonio L Damato, Megan Kassick, Akila N Viswanathan
PURPOSE: The aim of this study was to evaluate injection of a novel hydrogel (TraceIT; Augmenix, Waltham, MA) between the cervix, rectum, and bladder in female cadavers compared with, and in addition to, the current standard of gauze packing, for organ-at-risk sparing in cervical cancer brachytherapy planning. METHODS AND MATERIALS: This brachytherapy cadaver study used T2-weighted MRI and CT imaging to compare three scenarios: (1) gauze packing alone, (2) hydrogel injection placed in the cervical fornices and rectovaginal septum, and (3) gauze packing in conjunction with hydrogel injection...
June 12, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28604459/definitive-chemoradiotherapy-in-elderly-cervical-cancer-patients-a-multiinstitutional-analysis
#3
Ozan Cem Guler, Sezin Yuce Sari, Sumerya Duru Birgi, Melis Gultekin, Ferah Yildiz, Cem Onal
OBJECTIVE: The aim of the study was to investigate the prognostic factors for survival and treatment-related toxicities in older (≥65 years) cervical cancer patients treated with definitive chemoradiotherapy. In addition, we sought to compare the outcomes between the older elderly (≥75 years) and their younger old counterparts (age, 65-74 years). MATERIALS AND METHODS: We retrospectively reviewed medical records from 269 biopsy-proven nonmetastatic cervical cancer patients treated with external radiotherapy and intracavitary brachytherapy at the departments of radiation oncology in 2 different universities...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28603722/external-beam-techniques-to-boost-cervical-cancer-when-brachytherapy-is-not-an-option-theories-and-applications
#4
REVIEW
Omar Mahmoud, Sarah Kilic, Atif J Khan, Sushil Beriwal, William Small
The management of locally advanced cervical cancer relies on brachytherapy (BT) as an integral part of the radiotherapy delivery armamentarium. Occasionally, intracavitary BT is neither possible nor available. In these circumstances, post-external beam radiotherapy (EBRT) interstitial brachytherapy and/or hysterectomy may represent viable options that must be adequately executed in a timely manner. However, if these options are not applicable due to patient related or facility related reasons, a formal contingency plan should be in place...
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28602708/reduced-toxicity-with-equivalent-outcomes-using-three-dimensional-volumetric-3dv-image-based-versus-nonvolumetric-point-based-nv-brachytherapy-in-a-cervical-cancer-population
#5
Kimberly M Thomas, Genevieve Maquilan, Strahinja Stojadinovic, Paul Medin, Michael R Folkert, Kevin Albuquerque
PURPOSE: Brachytherapy (BT) techniques have historically used a two-dimensional nonvolumetric (NV) system involving dose prescribed to a point fixed in space. We compared dosimetric, toxicity, and oncologic outcomes for volumetric planning (3DV) versus CT point-based planning. METHODS AND MATERIALS: Patients treated with external beam radiation therapy and high dose rate (HDR) intracavitary BT were included (n = 71). Patients planned with NV BT treated from 2009 to 2011 (n = 37) were compared to patients planned with 3DV BT treated from 2012 to 2014 (n = 34)...
June 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28595311/evaluation-of-rectum-and-bladder-dose-accumulation-from-external-beam-radiotherapy-and-brachytherapy-for-cervical-cancer-using-two-different-deformable-image-registration-techniques
#6
Noriyuki Kadoya, YuYa Miyasaka, Takaya Yamamoto, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Noriyoshi Takahashi, Masaki Kubozono, Rei Umezawa, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We evaluated dose-volume histogram (DVH) parameters based on deformable image registration (DIR) between brachytherapy (BT) and external beam radiotherapy (EBRT) that included a center-shielded (CS) plan. Eleven cervical cancer patients were treated with BT, and their pelvic and CS EBRT were studied. Planning CT images for EBRT and BT (except for the first BT, used as the reference image) were deformed with DIR to reference image. We used two DIR parameter settings: intensity-based and hybrid. Mean Dice similarity coefficients (DSCs) comparing EBRT with the reference for the uterus, rectum and bladder were 0...
June 8, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28578919/opioid-consumption-and-pain-in-gynecological-cancer-patients-treated-with-interstitial-brachytherapy
#7
Lucas C Mendez, Stephen Choi, Laura D'Alimonte, Elizabeth Barnes, Lisa Barbera, Eric Leung
PURPOSE: Interstitial brachytherapy (ISBT) has advantages over the intracavitary techniques in the treatment of gynecological malignancies. The insertion of catheters into tumor enables higher dose conformality and normal tissue sparing. However ISBT can be associated with pain due its invasiveness. The goal of this study is to assess pain and opioid consumption of patients implanted with a perineal ISBT applicator. METHODS AND MATERIALS: Forty-eight patients were treated with ISBT from September 2014 to April 2016...
May 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28574816/prediction-of-cervical-cancer-recurrence-using-textural-features-extracted-from-18f-fdg-pet-images-acquired-with-different-scanners
#8
Sylvain Reuzé, Fanny Orlhac, Cyrus Chargari, Christophe Nioche, Elaine Limkin, François Riet, Alexandre Escande, Christine Haie-Meder, Laurent Dercle, Sébastien Gouy, Irène Buvat, Eric Deutsch, Charlotte Robert
OBJECTIVES: To identify an imaging signature predicting local recurrence for locally advanced cervical cancer (LACC) treated by chemoradiation and brachytherapy from baseline 18F-FDG PET images, and to evaluate the possibility of gathering images from two different PET scanners in a radiomic study. METHODS: 118 patients were included retrospectively. Two groups (G1, G2) were defined according to the PET scanner used for image acquisition. Eleven radiomic features were extracted from delineated cervical tumors to evaluate: (i) the predictive value of features for local recurrence of LACC, (ii) their reproducibility as a function of the scanner within a hepatic reference volume, (iii) the impact of voxel size on feature values...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28551312/locally-advanced-cervical-cancer-is-it-relevant-to-report-image-guided-adaptive-brachytherapy-using-point-a-dose
#9
Renaud Mazeron, Sebastien Gouy, Alexandre Escande, Isabelle Dumas, Eleonor Rivin Del Campo, Enrica Bentivegna, Warren Bocorro, Dimitri Lefkopoulos, Eric Deutsch, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To evaluate the usefulness of reporting the point A dose in patients with locally advanced cervical cancer treated with image-guided adaptive brachytherapy (IGABT). METHODS AND MATERIALS: Dosimetric data from patients treated with a combination of chemoradiation and intracavitary IGABT were examined in light of their outcomes. Prescribing followed the Groupe Européen de Curiethérapie-European Society for Radiation Oncology recommendations. All doses were converted in 2-Gy equivalent...
May 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28533808/how-one-institution-overcame-the-challenges-to-start-an-mri-based-brachytherapy-program-for-cervical-cancer
#10
REVIEW
Matthew M Harkenrider, Steven M Shea, Abbie M Wood, Bonnie Chinsky, Amishi Bajaj, Michael Mysz, Joseph H Yacoub, Ari Goldberg, Margaret Liotta, Ronald Potkul, Murat Surucu, John Roeske, William Small
PURPOSE: Adaptive magnetic resonance imaging (MRI)-based brachytherapy results in improved local control and decreased high-grade toxicities compared to historical controls. Incorporating MRI into the workflow of a department can be a major challenge when initiating an MRI-based brachytherapy program. This project aims to describe the goals, challenges, and solutions when initiating an MRI-based cervical cancer brachytherapy program at our institution. MATERIAL AND METHODS: We describe the 6-month multi-disciplinary planning phase to initiate an MRI-based brachytherapy program...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533804/the-use-of-trans-applicator-intracavitary-ultrasonography-in-brachytherapy-for-cervical-cancer-phantom-study-of-a-novel-approach-to-3d-image-guided-brachytherapy
#11
Tomoaki Tamaki, Kazunori Miyaura, Toshihiro Murakami, Yu Kumazaki, Yoshiyuki Suzuki, Takashi Nakano, Shingo Kato
PURPOSE: To assess the feasibility of applying trans-applicator intracavitary ultrasonography to image-guided brachytherapy for cervical cancer. MATERIAL AND METHODS: For this experiment, a phantom was created and included a polyethylene tube, intended to simulate a tandem applicator, which was inserted into chicken meat and embedded in agar, along with magnetic resonance imaging (MRI)-compatible ovoid applicators. Three-dimensional images of the phantom were obtained using computed tomography (CT), MRI (T2-weighted), and intracavitary ultrasonography sectional images acquired at 1 mm slice intervals...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533798/optimal-bladder-filling-during-high-dose-rate-intracavitary-brachytherapy-for-cervical-cancer-a-dosimetric-study
#12
Umesh Mahantshetty, Saurabha Shetty, Dipanjan Majumder, Pranjal Adurkar, Jamema Swamidas, Reena Engineer, Supriya Chopra, Shyamkishore Shrivastava
PURPOSE: The aim of this study is to compare 3D dose volume histogram (DVH) parameters of bladder and other organs at risk with different bladder filling protocol during high-dose-rate intracavitary brachytherapy (HDR-ICBT) in cervical cancer, and to find optimized bladder volume. MATERIAL AND METHODS: This dosimetric study was completed with 21 patients who underwent HDR-ICBT with computed tomography/magnetic resonance compatible applicator as a routine treatment...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#13
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28529679/new-era-of-electronic-brachytherapy
#14
EDITORIAL
Prabhakar Ramachandran
Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#15
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28466646/ultrasound-guided-transvaginal-thrombin-injection-of-uterine-arteries-pseudoaneurysms
#16
Cristina Ros, Daniel Barnes, Anna Fervienza, Gabriella Oses, Juan L Alcázar, Sergio Martínez-Román, Àngels Rovirosa, Francisco Carmona, Fernando Gómez
OBJECTIVE: To evaluate the utility of transvaginal ultrasound-guided thrombin injection (UGTI) to treat uterine artery pseudoaneurysms (UAPs) as an alternative to emergency arterial embolization. METHODS: Two females presenting with heavy vaginal bleeding were diagnosed with UAPs by pelvic CT scan. After UAP identification by transvaginal ultrasound, 2 cm(3) of thrombin (Tissucol(®); Baxter Healthcare Corporation, Munich, Germany) was slowly injected into the UAPs using a 30-cm long 22-gauge needle through a needle guide attached to the vaginal probe...
June 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28464289/cervical-cancer-a-global-health-crisis
#17
REVIEW
William Small, Monica A Bacon, Amishi Bajaj, Linus T Chuang, Brandon J Fisher, Matthew M Harkenrider, Anuja Jhingran, Henry C Kitchener, Linda R Mileshkin, Akila N Viswanathan, David K Gaffney
Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28457817/-comparison-of-survival-and-chronic-gastrointestinal-toxicities-in-patients-with-locally-advanced-cervical-cancer-treated-by-conventional-or-intensity-modulated-radiation-technique
#18
C Gamelon-Bénichou, S Oldrini, C Charra-Brunaud, G Vogin, J Salleron, D Peiffert
PURPOSE: To evaluate prospectively chronic gastrointestinal toxicity in patients with cervical cancer treated with conventional irradiation or with intensity-modulated irradiation (IMRT). PATIENTS AND METHODS: Between June 2005 and September 2013, 109 patients underwent external radiotherapy followed by brachytherapy for cervical cancer at the "Institut de Cancérologie de Lorraine". Each patient receiving IMRT was paired with a patient receiving conventional radiotherapy on the following criteria: concomitant chemotherapy, additional nodal dose, treatment of para-aortic lymph node area, age...
May 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28457741/commissioning-of-applicator-guided-stereotactic-body-radiation-therapy-boost-with-high-dose-rate-brachytherapy-for-advanced-cervical-cancer-using-radiochromic-film-dosimetry
#19
Saad Aldelaijan, Shada Wadi-Ramahi, Ahmad Nobah, Belal Moftah, Slobodan Devic, Noha Jastaniyah
PURPOSE: To describe an EBT3 GAFCHROMIC film-based dosimetry method to be used in commissioning of a combined HDR brachytherapy (HDRB) and stereotactic body radiation therapy (SBRT) boost for treatment of advanced cervical cancer involving extensive residual disease after external beam treatment. METHODS AND MATERIALS: A cube phantom was designed to firmly fit an intrauterine tandem applicator and EBT3 radiochromic film pieces. A high-risk clinical target volume (CTVHR, Total) was contoured with an extended arm at one side...
April 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28455092/use-of-3d-transabdominal-ultrasound-imaging-for-treatment-planning-in-cervical-cancer-brachytherapy-comparison-to-magnetic-resonance-and-computed-tomography
#20
Patricia St-Amant, William Foster, Marie-Anne Froment, Sylviane Aubin, Marie-Claude Lavallée, Luc Beaulieu
PURPOSE: To evaluate if the addition of 3D transabdominal ultrasound (3DTAUS) imaging to computed tomography (CT) can improve treatment planning in 3D adaptive brachytherapy when compared with CT-based planning alone, resulting in treatment plans closer to the ones obtained using magnetic resonance imaging (MRI)-based planning. METHODS AND MATERIALS: Five patients with cervical cancer undergoing brachytherapy underwent three imaging modalities: MRI, CT, and CT-3DTAUS...
April 25, 2017: Brachytherapy
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