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Cervical cancer brachytherapy

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https://www.readbyqxmd.com/read/28533808/how-one-institution-overcame-the-challenges-to-start-an-mri-based-brachytherapy-program-for-cervical-cancer
#1
REVIEW
Matthew M Harkenrider, Steven M Shea, Abbie M Wood, Bonnie Chinsky, Amishi Bajaj, Michael Mysz, Joseph H Yacoub, Ari Goldberg, Margaret Liotta, Ronald Potkul, Murat Surucu, John Roeske, William Small
PURPOSE: Adaptive magnetic resonance imaging (MRI)-based brachytherapy results in improved local control and decreased high-grade toxicities compared to historical controls. Incorporating MRI into the workflow of a department can be a major challenge when initiating an MRI-based brachytherapy program. This project aims to describe the goals, challenges, and solutions when initiating an MRI-based cervical cancer brachytherapy program at our institution. MATERIAL AND METHODS: We describe the 6-month multi-disciplinary planning phase to initiate an MRI-based brachytherapy program...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533804/the-use-of-trans-applicator-intracavitary-ultrasonography-in-brachytherapy-for-cervical-cancer-phantom-study-of-a-novel-approach-to-3d-image-guided-brachytherapy
#2
Tomoaki Tamaki, Kazunori Miyaura, Toshihiro Murakami, Yu Kumazaki, Yoshiyuki Suzuki, Takashi Nakano, Shingo Kato
PURPOSE: To assess the feasibility of applying trans-applicator intracavitary ultrasonography to image-guided brachytherapy for cervical cancer. MATERIAL AND METHODS: For this experiment, a phantom was created and included a polyethylene tube, intended to simulate a tandem applicator, which was inserted into chicken meat and embedded in agar, along with magnetic resonance imaging (MRI)-compatible ovoid applicators. Three-dimensional images of the phantom were obtained using computed tomography (CT), MRI (T2-weighted), and intracavitary ultrasonography sectional images acquired at 1 mm slice intervals...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533798/optimal-bladder-filling-during-high-dose-rate-intracavitary-brachytherapy-for-cervical-cancer-a-dosimetric-study
#3
Umesh Mahantshetty, Saurabha Shetty, Dipanjan Majumder, Pranjal Adurkar, Jamema Swamidas, Reena Engineer, Supriya Chopra, Shyamkishore Shrivastava
PURPOSE: The aim of this study is to compare 3D dose volume histogram (DVH) parameters of bladder and other organs at risk with different bladder filling protocol during high-dose-rate intracavitary brachytherapy (HDR-ICBT) in cervical cancer, and to find optimized bladder volume. MATERIAL AND METHODS: This dosimetric study was completed with 21 patients who underwent HDR-ICBT with computed tomography/magnetic resonance compatible applicator as a routine treatment...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#4
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28529679/new-era-of-electronic-brachytherapy
#5
EDITORIAL
Prabhakar Ramachandran
Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#6
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28466646/ultrasound-guided-transvaginal-thrombin-injection-of-uterine-arteries-pseudoaneurysms
#7
Cristina Ros, Daniel Barnes, Anna Fervienza, Gabriella Oses, Juan Luis Alcázar, Sergio Martínez-Román, Àngels Rovirosa, Francisco Carmona, Fernando Gómez
OBJECTIVE: To evaluate the utility of transvaginal ultrasound-guided thrombin injection (UGTI) to treat uterine artery pseudoaneurysms (UAP) as an alternative to emergency arterial embolization. METHODS: Two women presenting with heavy vaginal bleeding were diagnosed with UAP by pelvic CT scan. After UAP identification by transvaginal ultrasound (TVUS), 2 cc of thrombin (Tissucol(®), Baxter Healthcare Corporation. Munich, Germany) were slowly injected into the UAP using a 30 cm long 22-gauge needle through a needle-guide attached to the vaginal probe...
May 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28464289/cervical-cancer-a-global-health-crisis
#8
REVIEW
William Small, Monica A Bacon, Amishi Bajaj, Linus T Chuang, Brandon J Fisher, Matthew M Harkenrider, Anuja Jhingran, Henry C Kitchener, Linda R Mileshkin, Akila N Viswanathan, David K Gaffney
Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28457817/-comparison-of-survival-and-chronic-gastrointestinal-toxicities-in-patients-with-locally-advanced-cervical-cancer-treated-by-conventional-or-intensity-modulated-radiation-technique
#9
C Gamelon-Bénichou, S Oldrini, C Charra-Brunaud, G Vogin, J Salleron, D Peiffert
PURPOSE: To evaluate prospectively chronic gastrointestinal toxicity in patients with cervical cancer treated with conventional irradiation or with intensity-modulated irradiation (IMRT). PATIENTS AND METHODS: Between June 2005 and September 2013, 109 patients underwent external radiotherapy followed by brachytherapy for cervical cancer at the "Institut de Cancérologie de Lorraine". Each patient receiving IMRT was paired with a patient receiving conventional radiotherapy on the following criteria: concomitant chemotherapy, additional nodal dose, treatment of para-aortic lymph node area, age...
April 27, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28457741/commissioning-of-applicator-guided-stereotactic-body-radiation-therapy-boost-with-high-dose-rate-brachytherapy-for-advanced-cervical-cancer-using-radiochromic-film-dosimetry
#10
Saad Aldelaijan, Shada Wadi-Ramahi, Ahmad Nobah, Belal Moftah, Slobodan Devic, Noha Jastaniyah
PURPOSE: To describe an EBT3 GAFCHROMIC film-based dosimetry method to be used in commissioning of a combined HDR brachytherapy (HDRB) and stereotactic body radiation therapy (SBRT) boost for treatment of advanced cervical cancer involving extensive residual disease after external beam treatment. METHODS AND MATERIALS: A cube phantom was designed to firmly fit an intrauterine tandem applicator and EBT3 radiochromic film pieces. A high-risk clinical target volume (CTVHR, Total) was contoured with an extended arm at one side...
April 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28455092/use-of-3d-transabdominal-ultrasound-imaging-for-treatment-planning-in-cervical-cancer-brachytherapy-comparison-to-magnetic-resonance-and-computed-tomography
#11
Patricia St-Amant, William Foster, Marie-Anne Froment, Sylviane Aubin, Marie-Claude Lavallée, Luc Beaulieu
PURPOSE: To evaluate if the addition of 3D transabdominal ultrasound (3DTAUS) imaging to computed tomography (CT) can improve treatment planning in 3D adaptive brachytherapy when compared with CT-based planning alone, resulting in treatment plans closer to the ones obtained using magnetic resonance imaging (MRI)-based planning. METHODS AND MATERIALS: Five patients with cervical cancer undergoing brachytherapy underwent three imaging modalities: MRI, CT, and CT-3DTAUS...
April 25, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28434797/patterns-of-care-survey-radiotherapy-for-women-with-locally-advanced-cervical-cancer
#12
Peter de Boer, Ina M Jürgenliemk-Schulz, Henrike Westerveld, Astrid A C de Leeuw, Raquel Dávila-Fajardo, Coen R N Rasch, Bradley R Pieters, Lukas J A Stalpers
BACKGROUND AND PURPOSE: Regarding latest developments, the need of a radiotherapy 'Patterns of Care' survey was expressed by the Dutch National Platform Radiotherapy for Gynaecological Cancer (LPRGT). Therefore, this study investigated current practice for cervical cancer in all 16 radiation oncology centres in the Netherlands specialised in gynaecological oncology. MATERIAL AND METHODS: A structured 'patterns of care' questionnaire was completed and followed by an in-depth interview with radiation oncologists from all radiotherapy centres specialised in gynaecological oncology...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28388623/fzuimagereg-a-toolbox-for-medical-image-registration-and-dose-fusion-in-cervical-cancer-radiotherapy
#13
Qinquan Gao, Shaohui Lin, Penggang Bai, Min Du, Xiaolei Ni, Dongzhong Ke, Tong Tong
The combination external-beam radiotherapy and high-dose-rate brachytherapy is a standard form of treatment for patients with locally advanced uterine cervical cancer. Personalized radiotherapy in cervical cancer requires efficient and accurate dose planning and assessment across these types of treatment. To achieve radiation dose assessment, accurate mapping of the dose distribution from HDR-BT onto EBRT is extremely important. However, few systems can achieve robust dose fusion and determine the accumulated dose distribution during the entire course of treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28382802/major-clinical-research-advances-in-gynecologic-cancer-in-2016-10-year-special-edition
#14
REVIEW
Dong Hoon Suh, Miseon Kim, Kidong Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS)...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28372889/structure-based-deformable-image-registration-added-value-for-dose-accumulation-of-external-beam-radiotherapy-and-brachytherapy-in-cervical-cancer
#15
Laura E van Heerden, Antonetta C Houweling, Kees Koedooder, Zdenko van Kesteren, Niek van Wieringen, Coenraad R N Rasch, Bradley R Pieters, Arjan Bel
BACKGROUND AND PURPOSE: Structure-based deformable image registration (DIR) can be used to calculate accumulated brachytherapy (BT) and external-beam radiation therapy (EBRT) dose-volume histogram (DVH) parameters in cervical cancer. Since direct parameter addition does not take dose non-uniformity into account, the added value of DIR over addition methods was investigated for bladder and rectum. MATERIALS AND METHODS: For twelve patients (EBRT: 46Gy, EBRT+BT: D90 85-90GyEQD2 in equivalent dose in 2Gy fractions) the EBRT planning CT and BT planning MRI were registered using DIR...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28365083/clinical-transition-to-model-based-dose-calculation-algorithm-a-retrospective-analysis-of-high-dose-rate-tandem-and-ring-brachytherapy-of-the-cervix
#16
Dayee Jacob, Melissa Lamberto, Lana DeSouza Lawrence, Firas Mourtada
PURPOSE: To retrospectively compare clinical dosimetry of CT-based tandem-ring treatment plans using a model-based dose calculation algorithm (MBDCA) with the standard TG-43-based dose formalism. METHODS AND MATERIALS: A cohort of 10 cervical cancer cohorts treated using the tandem and ring high-dose-rate applicators were evaluated. The original treatment plans were created using the department CT-based volume optimization clinical standards. All plans originally calculated with TG-43 dose calculation formalism were recalculated using the MBDCA algorithm...
May 2017: Brachytherapy
https://www.readbyqxmd.com/read/28363728/pelvic-radiotherapy-in-the-setting-of-rheumatoid-arthritis-refining-the-paradigm
#17
T Felefly, R Mazeron, A Huertas, C H Canova, P Maroun, M Kordahi, P Morice, É Deutsch, C Haie-Méder, C Chargari
PURPOSE: Conflicting results concerning the toxicity of radiotherapy in the setting of rheumatoid arthritis were reported in literature. This work describes the toxicity profiles of patients with rheumatoid arthritis undergoing pelvic radiotherapy for gynecologic malignancies at our institution. PATIENTS AND METHODS: Charts of patients with rheumatoid arthritis who underwent pelvic radiotherapy for cervical or endometrial cancer in a curative intent at the Gustave-Roussy Cancer Campus between 1990 and 2015 were reviewed for treatment-related toxicities...
March 28, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28351521/three-dimensional-guided-perineal-based-interstitial-brachytherapy-in-cervical-cancer-a-systematic-review-of-technique-local-control-and-toxicities
#18
Lucas C Mendez, Yonatan Weiss, David D'Souza, Ananth Ravi, Lisa Barbera, Eric Leung
OBJECTIVE: To evaluate local control and toxicities of perineal-based interstitial brachytherapy (P-ISBT) in cervical cancers treated with three-dimensional (3D) image-based planning through a systematic review. The secondary objective of this review is to summarize the implant and dosimetric techniques in 3D P-ISBT. METHODS: Systematic review of the literature using the PRISMA guideline was conducted through a search of Medline, EMBASE and Cochrane databases. This search resulted in 19 relevant manuscripts...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28344604/3d-image-based-adapted-high-dose-rate-brachytherapy-in-cervical-cancer-with-and-without-interstitial-needles-measurement-of-applicator-shift-between-imaging-and-dose-delivery
#19
Leif Karlsson, Per Thunberg, Anders With, Louise Bohr Mordhorst, Jan Persliden
PURPOSE: Using 3D image-guided adaptive brachytherapy for cervical cancer treatment, it often means that patients are transported and moved during the treatment procedure. The purpose of this study was to determine the intra-fractional longitudinal applicator shift in relation to the high risk clinical target volume (HR-CTV) by comparing geometries at imaging and dose delivery for patients with and without needles. MATERIAL AND METHODS: Measurements were performed in 33 patients (71 fractions), where 25 fractions were without and 46 were with interstitial needles...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28336252/trends-in-cervical-cancer-brachytherapy-volume-suggest-case-volume-is-not-the-primary-driver-of-poor-compliance-rates-with-brachytherapy-delivery-for-locally-advanced-cervical-cancer
#20
Daniel M Trifiletti, Surbhi Grover, Bruce Libby, Timothy N Showalter
PURPOSE: The aim of this study was to evaluate temporal trends in the volume of cervical cancer brachytherapy cases available to trainees as a potential contributing factor to national trends toward decreased utilization of brachytherapy for locally advanced cervical cancer. METHODS AND MATERIALS: The National Cancer Database was queried to identify a cohort of women diagnosed with locally advanced cervical cancer during 2004-2013 who received primary radiation therapy...
May 2017: Brachytherapy
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