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https://www.readbyqxmd.com/read/28712580/single-dose-del-nido-cardioplegia-in-minimally-invasive-aortic-valve-surgery
#1
Daniel Ziazadeh, Regina Mater, Ben Himelhoch, Andrew Borgman, Jessica L Parker, Charles L Willekes, Tomasz A Timek
BACKGROUND: The del Nido cardioplegia (DC) procedure offers prolonged cardiac protection with single-dose administration and has proven safe in adult coronary artery bypass grafting (CABG) surgery. We set out to evaluate the efficacy of cardiac protection and clinical outcomes of DC versus standard blood cardioplegia (BC) in minimally invasive aortic valve surgery. METHODS: Between August 2011 and May 2016, 178 patients underwent minimally invasive aortic valve replacement (AVR) with BC (n = 101) or DC (n = 77)...
June 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28710670/management-of-proximal-humeral-fractures-by-the-ilizarov-external-fixator
#2
Mohammed Anter Meselhy, Mohamed Salah Singer
INTRODUCTION: External fixation can be performed in poor bone and soft tissue conditions, and can be used in patients with poor general conditions or multiple injuries as a rapid, mini-invasive procedure. The purpose of the current study was to evaluate the effectiveness and safety of the Ilizarov external fixator in the management of proximal humeral fractures. MATERIALS AND METHODS: Between May 2011 and December 2013, 14 patients with displaced proximal humeral fractures were enrolled in the current study...
July 14, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28707595/functional-roles-of-the-ca2-activated-k-channel-kca3-1-in-brain-tumors
#3
Giuseppina D Alessandro, Cristina Limatola, Myriam Catalano
Glioblastoma is the most aggressive and deadly brain tumor, with low disease-free period even after surgery and combined radio and chemotherapies. Among the factors contributing to rapid tumor growth in the brain are the elevated proliferation and invasion rate, and the ability to induce a local immunosuppressive environment. The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is expressed on glioblastoma cells and in tumor-infiltrating cells. In tumor cells, the functional expression of KCa3.1 is important to modulate cell invasion and proliferation...
July 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28695312/use-of-biological-mesh-in-trans-anal-treatment-for-recurrent-recto-urethral-fistula
#4
G Moretto, A Casaril, M Inama
PURPOSE: To report the author's experience on a mini-invasive technique using bioprosthetic plug and a rectal wall flap advancement in the treatment of recurrent recto-urethral fistula. MATERIALS AND METHODS: Between 2013 and 2015, seven patients with recurrent recto-urethral fistula were referred to the Pederzoli Hospital, Peschiera del Garda, Verona, Italy. Intraoperatively all patients were found to have a rectal wall lesion and were treated with urinary and fecal diversion...
July 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28694654/evolution-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-simpler-safer-and-equally-effective-methods
#5
EDITORIAL
Shu-You Peng, Xu-An Wang, Cong-Yun Huang, You-Yong Zhang, Jiang-Tao Li, De-Fei Hong, Xiu-Jun Cai
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently demonstrated as a method to induce rapid and extensive hypertrophy within a short time and has been employed for a variety of primary and metastatic liver tumors. However, controversies remain due to its high morbidity and mortality. To enable safer surgery, liver surgeons have searched for better technical modifications, such as partial ALPPS, mini-ALPPS, minimally invasive ALPPS, and Terminal branches portal vein Embolization Liver Partition for Planned hepatectomy (TELPP)...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28692889/dynamic-real-time-in-vivo-confocal-laser-endomicroscopy-of-the-fallopian-tube-during-laparoscopy-in-the-prevention-of-ovarian-cancer
#6
Gautier Chene, Lauriane Chauvy, Annie Buenerd, Stéphanie Moret, Béatrice Nadaud, Philippe Chabert, Gery Lamblin
OBJECTIVES: Recently it has been postulated that most ovarian cancers have a tubal origin. The identification of preinvasive tubal lesions would be of great interest in the early diagnosis of ovarian cancer. Optical biopsy has been developed and validated in the detection of precancerous lesions (such as Barrett's oesophagus). The first objective of this study was to assess the feasibility of optical biopsy in the study of fallopian tubes during laparoscopy. The second objective was to describe the images in benign premalignant and malignant tubes with a histopathological and immunohistochemical (p53 and Ki67 expressions) correlation...
July 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28691974/peroral-endoscopic-myotomy-in-children-with-achalasia-a-relatively-long-term-single-center-study
#7
Miao Shijian, Wu Jie, Lu Junping, Wang Yuhuan, Tang Zifei, Zhou Ying, Huang Zhiheng, Ying Huang, Zhou Pinghong
BACKGROUND: Achalasia is a disease caused by neuromuscular dysfunction in the esophagogastric junction, with a relatively low incidence among children. Peroral endoscopic myotomy (POEM) is a new endoscopic procedure for the treatment of achalasia, however it is rarely applied in children. OBJECTIVES: We aim to study the feasibility, safety, and effectiveness of POEM as a treatment for pediatric achalasia. METHODS: A total of 21 pediatric patients (aged from 11 months to 18 years) diagnosed with achalasia and treated with POEM from October of 2014 to October of 2016 in our hospital were included in our study...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28688799/trephination-mini-craniectomy-for-traumatic-posterior-fossa-epidural-hematomas-in-selected-pediatric-patients
#8
Han-Song Sheng, Chao-Guo You, Liang Yang, Nu Zhang, Jian Lin, Fen-Chun Lin, Mao-De Wang
PURPOSE: Posterior fossa epidural hematomas (PFEDH) are uncommon in children but usually require timely surgical intervention due to the risk of life-threatening brainstem compression. We attempt to make the surgical procedure less invasive by treating selected pediatric patients with trephination mini-craniectomy. METHODS: We retrospectively reviewed the clinical courses, radiological findings, surgical procedures, and prognoses of the pediatric patients who were treated in our departments for traumatic PFEDH from January 2010 to January 2015...
June 22, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28685876/eus-fna-of-the-merkel-cell-carcinoma-metastasis-to-the-pancreas-cytomorphology-and-immunocytochemistry-on-direct-cytological-smears
#9
T Stoos-Veic, M Tadic, G Aralica, V Milicic, C Tomasovic-Loncaric
OBJECTIVE: To report two cases of Merkel cell carcinoma (MCC) metastatic to the pancreas diagnosed with endoscopic ultrasound-guided-fine needle aspiration (EUS-FNA) and to add the case of concomitant chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and MCC to the literature. The aim is to alert the cytopathologists once more to the problems of differential diagnosis of pancreatic metastasis of MCC and to describe the possibilities of ancillary methods performed on direct cytological smears...
July 6, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28685456/relation-between-cognitive-function-and-baseline-concentrations-of-hemoglobin-in-prefrontal-cortex-of-elderly-people-measured-by-time-resolved-near-infrared-spectroscopy
#10
Y Murayama, Y Sato, L Hu, A Brugnera, A Compare, Kaoru Sakatani
We evaluated relationship between cognitive function and cerebral blood oxygenation (CBO) of the prefrontal cortex (PFC) at rest in 113 adults (age 72.3 ± 12.0 years). We employed a two channel time-resolved near-infrared spectroscopy (TRS), which allows non-invasive measurements of baseline concentrations of oxyhemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb), total-hemoglobin (t-Hb) (μM) and oxygen saturation (SO2, %) of the bilateral PFC without any tasks. We examined cognitive functions using the Mini-Mental State Examination (MMSE) (range from 0 to 30) and the Touch M which evaluates working memory function semi-automatically on a touchscreen (range from 0 to 100); the mean MMSE and Touch M scores of all subjects were 24...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28681887/manipulating-tumor-hypoxia-toward-enhanced-photodynamic-therapy-pdt
#11
Juanjuan Dang, Hua He, Donglai Chen, Lichen Yin
Photodynamic therapy (PDT) is considered a promising approach for the treatment of cancer and is achieved via the photosensitizer (PS)-mediated incomplete reduction of oxygen upon light irradiation, which generates high levels of reactive oxygen species (ROS) to induce potent vascular damage and to directly kill tumor cells. However, there is an undesirable impediment with this approach in that tumor tissues generally suffer from serious hypoxia, which significantly affects the efficiency of PDT. Additionally, PDT that consumes oxygen will further aggravate tumor hypoxia, thus potentially leading to multiple undesirable consequences, such as angiogenesis, tumor invasiveness, and tumor metastasis...
July 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28669786/post-operative-outcomes-among-pediatric-and-adolescent-patients-undergoing-mini-laparotomy-vs-laparoscopy-in-the-management-of-adnexal-lesions
#12
Gylynthia Trotman, Christine Foley, Janelle Taylor, Sameer DeSale, Veronica Gomez-Lobo
STUDY OBJECTIVE: To compare institutional experience in the postoperative recovery in children and adolescents undergoing laparoscopy versus mini-laparotomy in the management of benign adnexal cystic lesions. DESIGN: Retrospective Cohort. SETTING: Tertiary care children's hospital. PARTICIPANTS: Patients ages 6 -21 who underwent surgical management for benign adnexal lesions. MAIN OUTCOME MEASURES: Comparison of operative times, size of lesions, pain scores, patient length of stay after mini-laparotomy versus laparoscopy...
June 29, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28662708/comparison-of-the-efficacy-and-safety-of-ursl-rplu-and-mpcnl-for-treatment-of-large-upper-impacted-ureteral-stones-a-randomized-controlled-trial
#13
Yunyan Wang, Bing Zhong, Xiaosong Yang, Gongcheng Wang, Peijin Hou, Junsong Meng
BACKGROUND: There are three minimally invasive methods for the management of large upper impacted ureteral stones: mini-percutaneous nephrolithotomy (MPCNL), transurethral ureteroscope lithotripsy (URSL), and retroperitoneal laparoscopic ureterolithotomy (RPLU). This study aimed to compare MPCNL, URSL, and RPLU, and to evaluate which one is the best choice for large upper impacted ureteral stones. METHODS: Between January 2012 and December 2015, at the Department of Urology, Huai'an First People's Hospital, 150 consecutively enrolled patients with a large upper impacted ureteral stone (>15 mm) were included...
June 29, 2017: BMC Urology
https://www.readbyqxmd.com/read/28655630/a-novel-anterior-approach-for-the-fixation-of-ulnar-coronoid-process-fractures
#14
Xiaohua Yang, Wenli Chang, Wei Chen, Song Liu, Yanbin Zhu, Yingze Zhang
BACKGROUND: There is no universally accepted approachto the elbow for the fixation of coronoid process fractures.This study aims to introduce a novel anterior surgicalapproach for the fixation of the ulnar coronoid fracture, with minimal surgical dissection damage and excellent visualization for reduction and internal fixation. HYPOTHESIS: The anterior approach can facilitatesatisfactory outcomesfor coronoid process fractures. MATERIAL AND METHODS: From February 2010 to July 2014, 12 patients (8 males and 4 females; range 14-62 years; mean age 31 years) with a closed fracture of the coronoid process of the ulna were included in this study...
June 24, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28651347/minimally-invasive-centrimag-ventricular-assist-device-support-integrated-with-extracorporeal-membrane-oxygenation-in-cardiogenic-shock-patients-a-comparison-with-conventional-centrimag-biventricular-support-configuration
#15
Koji Takeda, Arthur R Garan, Masahiko Ando, Jiho Han, Veli K Topkara, Paul Kurlansky, Melana Yuzefpolskaya, Maryjane A Farr, Paolo C Colombo, Yoshifumi Naka, Hiroo Takayama
OBJECTIVES: We recently developed a novel minimally invasive surgical approach that combines extracorporeal membrane oxygenation and CentriMag ventricular assist device (Ec-VAD) for the treatment of cardiogenic shock as a short-term circulatory support. We compared the outcomes of this new approach to conventional CentriMag biventricular assist device (BiVAD) support through a median sternotomy. METHODS: Between July 2015 and August 2016, 22 patients were implanted with CentriMag Ec-VAD and 90 patients were implanted with conventional CentriMag BiVAD...
June 22, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28648650/planning-execution-and-follow-up-for-endovascular-aortic-aneurysm-repair-using-a-highly-restrictive-iodinated-contrast-protocol-in-patients-with-severe-renal-disease
#16
E Gallitto, G L Faggioli, M Gargiulo, A Freyrie, R Pini, C Mascoli, S Ancetti, V Vento, A Stella
BACKGROUND: The cumulative amount of iodinated-contrast-medium necessary for EVAR planning, operative procedure and subsequent follow-up is a threat for the onset of end stage renal disease in patients with pre-operative impaired kidney function. Purpose of this study is to describe a mini-invasive approach aimed to minimize the exposure of these patients to iodinated-contrast-medium and the subsequent risk of renal function worsening. METHODS: From 2012 to 2015, all patients with abdominal aortic aneurysm (AAA) at high-surgical risk and fit for standard endovascular repair (simple aortic-iliac anatomy: proximal and distal neck length ≥15mm, no severe angulation), underwent EVAR through the following "near-zero contrast" approach, if their glomerular filtration rate (GFR) was <30 mL/min: pre-operative planning was performed by non-contrast enhanced computed tomography (CT) and duplex-ultrasound (DU); the origin of renal/hypogastric arteries and aortic bifurcation was evaluated and matched with vertebral bone landmarks and the endograft deployed accordingly, using < 20cc of isotonic iodinate-contrast-medium and contrast-enhancement-DU (CEUS)...
June 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28642743/hiv-1-nef-signaling-in-intestinal-mucosa-epithelium-suggests-the-existence-of-an-active-inter-kingdom-crosstalk-mediated-by-exosomes
#17
REVIEW
Cristina Felli, Olimpia Vincentini, Marco Silano, Andrea Masotti
The human intestinal mucosal surface represents the first defense against pathogens and regulates the immune response through the combination of epithelial cell (EC) functions and immunological factors. ECs act as sensors of luminal stimuli and interact with the immune cells through signal-transduction pathways, thus representing the first barrier that HIV-1 virus encounters during infection. In particular, the HIV-1 Nef protein plays a crucial role in viral invasion and replication. Nef is expressed early during viral infection and interacts with numerous cellular proteins as a scaffold/adaptor...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28638351/transcranial-direct-current-stimulation-considerations-for-research-in-adolescent-depression
#18
REVIEW
Jonathan C Lee, Charles P Lewis, Zafiris J Daskalakis, Paul E Croarkin
Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28637736/transcatheter-closure-mini-invasive-closure-and-open-heart-surgical-repair-for-treatment-of-perimembranous-ventricular-septal-defects-in-children-a-protocol-for-a-network-meta-analysis
#19
Tao You, Kang Yi, Zhao-Hong Ding, Xiao-Dong Hou, Xing-Guang Liu, Xin-Kuan Wang, Long Ge, Jin-Hui Tian
INTRODUCTION: Both transcatheter device closure and surgical repair are effective treatments with excellent midterm outcomes for perimembranous ventricular septal defects (pmVSDs) in children. The mini-invasive periventricular device occlusion technique has become prevalent in research and application, but evidence is limited for the assessment of transcatheter closure, mini-invasive closure and open-heart surgical repair. This study comprehensively compares the efficacy, safety and costs of transcatheter closure, mini-invasive closure and open-heart surgical repair for treatment of pmVSDs in children using Bayesian network meta-analysis...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28628014/-selection-of-mini-invasive-palliative-decompression-method-in-patients-with-malignant-obstruction-of-biliary-ducts-based-on-the-study-of-biochemical-bile-indexes
#20
M Bykov, R Sepiashvili, V Shchava, S Gobayeva, I Bykov, A Basov
The article gives our own experience in the determination and study of additional laboratory criteria (total lipids, cholesterol, maximum and area chemiluminescence, antioxidant activity) at the local level (in bile) in patients with bile duct obstruction of malignant etiology. Constellation of metabolic disorders allowed to propose an original method for determining the lithogenicity of bile (integral indicator of lithogenicity). The obtained data made it possible to justify the need to assess the degree of metabolic disturbances in bile, on the basis of which it is possible to predict the risk of lithogenesis and the duration of stent operation, which in turn helped optimize the algorithm for choosing the method of bile ducts decompression aimed at preventing early obturation of endoprostheses...
May 2017: Georgian Medical News
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