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https://www.readbyqxmd.com/read/27884869/sex-based-subgroup-differences-in-randomized-controlled-trials-empirical-evidence-from-cochrane-meta-analyses
#1
Joshua D Wallach, Patrick G Sullivan, John F Trepanowski, Ewout W Steyerberg, John P A Ioannidis
OBJECTIVE:  To evaluate the frequency, validity, and relevance of statistically significant (P<0.05) sex-treatment interactions in randomized controlled trials in Cochrane meta-analyses. DESIGN:  Meta-epidemiological study. DATA SOURCES:  Cochrane Database of Systematic Reviews (CDSR) and PubMed. ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Reviews published in the CDSR with sex-treatment subgroup analyses in the forest plots, using data from randomized controlled trials...
November 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27725323/-impact-in-the-quality-of-life-of-the-patients-with-double-j-catheter
#2
G Ordaz-Jurado, A Budía-Alba, P Bahilo-Mateu, J D López-Acón, M Trassierra-Villa, F Boronat-Tormo
OBJECTIVE: Double J ureteral stents are frequently used to allow free diuresis from the kidney to the bladder, but their presence has a major impact on patient's quality of life (QoL). Our aim is to describe such impact, and to describe possible solutions that can alleviate the symptoms associated with their use. METHODS: Systematic search in bibliographic sources including Cochrane library, UpToDate, Pubmed, Tripdatabase, selecting publications between 2000- 2015, and also the EAU European guidelines (2016)...
October 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27577349/usability-evaluation-of-clinical-guidelines-on-the-web-using-eye-tracker
#3
Soudabeh Khodambashi, Heidi Gilstad, Øystein Nytrø
Publishing clinical guidelines (GLs) on the web increases their accessibility. However, evaluating their usability and understanding how users interact with the websites has been neglected. In this study we used Tobii eye-tracker to analyse users' interaction with five commercial and public GL sites popular in Norway (four in Norwegian and one English of US origin (UpToDate)). We measured number of clicks and usage rate for search functions, task completion time, users' objective and perception of task success rate...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/26861938/utilisation-of-helicopter-emergency-medical-services-in-the-early-medical-response-to-major-incidents-a-systematic-literature-review
#4
Anne Siri Johnsen, Sabina Fattah, Stephen J M Sollid, Marius Rehn
OBJECTIVE: This systematic review identifies, describes and appraises the literature describing the utilisation of helicopter emergency medical services (HEMS) in the early medical response to major incidents. SETTING: Early prehospital phase of a major incident. DESIGN: Systematic literature review performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Web of Science, PsycINFO, Scopus, Cinahl, Bibsys Ask, Norart, Svemed and UpToDate were searched using phrases that combined HEMS and 'major incidents' to identify when and how HEMS was utilised...
2016: BMJ Open
https://www.readbyqxmd.com/read/26684664/pain-management-after-outpatient-anterior-cruciate-ligament-reconstruction-a-systematic-review-of-randomized-controlled-trials
#5
Eric S Secrist, Kevin B Freedman, Michael G Ciccotti, Donald W Mazur, Sommer Hammoud
BACKGROUND: Effective pain management after anterior cruciate ligament (ACL) reconstruction improves patient satisfaction and function. PURPOSE: To collect and evaluate the available evidence from randomized controlled trials (RCTs) on pain control after ACL reconstruction. STUDY DESIGN: Systematic review. METHODS: A systematic literature review was performed using PubMed, Medline, Google Scholar, UpToDate, Cochrane Reviews, CINAHL, and Scopus following PRISMA guidelines (July 2014)...
September 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26618382/physiopathology-and-treatment-of-critical-bleeding-a-literature-review
#6
Celia González Guerrero, José Bruno Montoro Ronsano
OBJECTIVES: to develop the different factors involved in the physiopathology of trauma-induced coagulopathy, through a review of publications on the matter; as well as to assess the evidence available on the treatment of critical bleeding and the recommendations by clinical practice guidelines. METHODS: a search has been conducted on the bibliography published about the physiopathology and treatment of critical bleeding in the PUBMED, BestPractice, UpToDate databases and the Cochrane Plus Library...
November 2015: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/26540909/-pharmacological-treatment-in-palliative-care-drug-administration-route-continuous-subcutaneous-infusion-adverse-side-effects-symptom-management
#7
REVIEW
Rocío Dominguez Álvarez, Justo Calderón Carrasco, Francisco García Colchero, Salvador Postigo Mota, Eulalia Alburquerque Medina
OBJECTVE: To achieve well-being in patients in Palliative Care is required to know which are the most common symptoms, which are the drugs used for relief, which are the routes of administration of drugs that are suitable, how effective the drugs are and what incompatibilities, interactions and adverse effects occur. The aim of this article is to review the relevant issues in the management of the drugs commonly used by nursing in Palliative Care and presenting recommendations to clinical practice...
January 2015: Revista de Enfermería
https://www.readbyqxmd.com/read/25984847/screening-for-cancer-advice-for-high-value-care-from-the-american-college-of-physicians
#8
Timothy J Wilt, Russell P Harris, Amir Qaseem
BACKGROUND: Cancer screening is one approach to reducing cancer-related morbidity and mortality rates. Screening strategies vary in intensity. Higher-intensity strategies are not necessarily higher value. High-value strategies provide a degree of benefits that clearly justifies the harms and costs incurred; low-value screening provides limited or no benefits to justify the harms and costs. When cancer screening leads to benefits, an optimal intensity of screening maximizes value. Some aspects of screening practices, especially overuse and underuse, are low value...
May 19, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25971389/thromboprophylaxis-with-low-molecular-weight-heparin-versus-unfractionated-heparin-in-intensive-care-patients-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#9
REVIEW
Sigrid Beitland, Irene Sandven, Lill-Kristin Kjærvik, Per Morten Sandset, Kjetil Sunde, Torsten Eken
PURPOSE: To compare benefits and harms of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) as thromboprophylaxis in intensive care unit (ICU) patients. METHODS: We conducted a systematic review with meta-analysis and trial sequential analysis (TSA) of randomised controlled trials (RCTs) comparing LMWH with UFH as thromboprophylaxis in adult ICU patients. We searched Ovid Medline, PubMed, Embase, Cochrane Library, UpToDate, Guidelines International Network, PROSPERO and the metaRegister of Controlled Trials through 3 December 2014...
July 2015: Intensive Care Medicine
https://www.readbyqxmd.com/read/25927108/evidence-for-exercise-training-in-the-management-of-hypertension-in-adults
#10
REVIEW
Alexandra S Ghadieh, Basem Saab
UNLABELLED: OBJECTIVE To provide recommendations on exercise training as part of the management of hypertension in adults.Quality of evidence Evidence was found through a systematic search of PubMed, MEDLINE, EMBASE, Agency for Healthcare Research and Quality evidence-based reports, Bandolier, Clinical Evidence, the Institute for Clinical Systems Improvement guidelines, the National Guideline Clearinghouse database, UpToDate,and the Cochrane Database of Systematic Reviews (part of Ovid Evidence Based Medicine Reviews) for articles published from January 1973 to September 2013...
March 2015: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/25679928/-hierarchy-of-evidence-levels-of-evidence-and-grades-of-recommendation-from-current-use
#11
REVIEW
Carlos Manterola, Claudla Asenjo-Lobos, Tamara Otzen
There are multiple proposals and classifications that hierarchize evidence, which may confuse those who are dedicated to generate it both in health technology assessments, as for the development of clinical guidelines, etc. The aim of this manuscript is to describe the most commonly used classifications of levels of evidence and grades of recommendation, analyzing their main differences and applications so that the user can choose the one that better suits your needs and take this health decisions basing their practice on the best available evidence...
December 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/25662148/-pediatric-pancreatitis-evidence-based-management-guidelines-of-the-hungarian-pancreatic-study-group
#12
REVIEW
Andrea Párniczky, László Czakó, Zsolt Dubravcsik, Gyula Farkas, Péter Hegyi, István Hritz, Dezső Kelemen, Zita Morvay, Attila Oláh, Ákos Pap, Miklós Sahin-Tóth, Flóra Szabó, Zsolt Szentkereszti, Richárd Szmola, Tamás Takács, László Tiszlavicz, Gábor Veres, Ákos Szücs, Natália Lásztity
Pediatric pancreatitis is a rare disease with variable etiology. In the past 10-15 years the incidence of pediatric pancreatitis has been increased. The management of pediatric pancreatitis requires up-to-date and evidence based management guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidences. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary...
February 22, 2015: Orvosi Hetilap
https://www.readbyqxmd.com/read/25662147/-autoimmune-pancreatitis-evidence-based-management-guidelines-of-the-hungarian-pancreatic-study-group
#13
REVIEW
Zsolt Dubravcsik, Gyula Farkas, Péter Hegyi, István Hritz, Dezső Kelemen, Natália Lásztity, Zita Morvay, Attila Oláh, Ákos Pap, Andrea Párniczky, Miklós Sahin-Tóth, Zsolt Szentkereszti, Richárd Szmola, Tamás Takács, László Tiszlavicz, Ákos Szücs, László Czakó
Autoimmune pancreatitis is a rare disease which can even mimic pancreatic tumor, however, unlike the latter, it requires not surgical but conservative management. Correct diagnosis and differential diagnosis of autoimmune pancreatitis and treatment of these patients requires up-to-date and evidence based management guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidences. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and/or modified the international guidelines if it was necessary...
February 22, 2015: Orvosi Hetilap
https://www.readbyqxmd.com/read/25661971/-chronic-pancreatitis-evidence-based-management-guidelines-of-the-hungarian-pancreatic-study-group
#14
REVIEW
Tamás Takács, László Czakó, Zsolt Dubravcsik, Gyula Farkas, Péter Hegyi, István Hritz, Dezső Kelemen, Natália Lásztity, Zita Morvay, Attila Oláh, Ákos Pap, Andrea Párniczky, Árpád Patai, Miklós Sahin-Tóth, Zsolt Szentkereszti, Richárd Szmola, László Tiszlavicz, Ákos Szücs
Chronic pancreatitis is an inflammatory disease associated with structural and functional damage of the pancreas. In most cases pain, maldigestion and weight loss are the leading symptoms, which significantly worsen the quality of life. Correct diagnosis and differential diagnosis of chronic pancreatitis and treatment of these patients requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidence...
February 15, 2015: Orvosi Hetilap
https://www.readbyqxmd.com/read/25661970/-acute-pancreatitis-evidence-based-practice-guidelines-prepared-by-the-hungarian-pancreatic-study-group
#15
REVIEW
István Hritz, László Czakó, Zsolt Dubravcsik, Gyula Farkas, Dezső Kelemen, Natália Lásztity, Zita Morvay, Attila Oláh, Ákos Pap, Andrea Párniczky, Miklós Sahin-Tóth, Zsolt Szentkereszti, Richárd Szmola, Ákos Szücs, Tamás Takács, László Tiszlavicz, Péter Hegyi
Acute pancreatitis is one of the most common diseases of the gastrointestinal tract associated with significant morbidity and mortality that requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare evidence based guideline for the medical and surgical management of acute pancreatitis based on the available international guidelines and evidence. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and, if it was necessary, complemented and/or modified the international guidelines...
February 15, 2015: Orvosi Hetilap
https://www.readbyqxmd.com/read/25565651/radiographic-skeletal-survey-for-non-accidental-injury-systematic-review-and-development-of-a-national-new-zealand-protocol
#16
REVIEW
Karin L Phillips, Sonja T Bastin, David Davies-Payne, Diana Browne, Helen L Bird, Susan Craw, David Duncan, Philippa Depree, Alina Leigh, Andrew McLaughlin, Russell Metcalfe, Jean Murdoch, Kirsten Pearce, David Perry, Iona Thomas, Glen D Thomson, Sally Vogel, Francessa Wilson, Rita L Teele
INTRODUCTION: Clinically occult fractures from non-accidental injury (NAI) are best detected on radiographic skeletal survey. However, there are regional variations regarding the views included in such surveys. We undertook a systematic review of the evidence supporting skeletal survey protocols to design a protocol that could be implemented across New Zealand. METHODS: In June 2013, we searched Medline, Google Scholar, the Cochrane database, UpToDate and relevant reference lists for English-language publications on skeletal survey in NAI from 1946...
February 2015: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/25545450/obstetric-recommendations-in-american-congress-of-obstetricians-and-gynecologists-practice-bulletins-versus-uptodate-a-comparison
#17
REVIEW
Emily N B Myer, Gloria T Too, Ibrahim A Hammad, Shilpa Babbar, Charley E Martin, James B Hill, Sean B Blackwell, Suneet P Chauhan
OBJECTIVE: To compare the obstetric recommendations in American Congress of Obstetricians and Gynecologists (ACOG) practice bulletins (PB) with similar topics in UpToDate (UTD). STUDY DESIGN: We accessed all obstetric PB and cross-searched UTD (May 1999-May 2013). We analyzed only the PB which had corresponding UTD chapter with graded recommendations (level A-C). To assess comparability of recommendations for each obstetric topic, two maternal-fetal medicine (MFM) subspecialists categorized the statement as similar, dissimilar, or incomparable...
April 2015: American Journal of Perinatology
https://www.readbyqxmd.com/read/25243838/the-role-of-sonographic-cervical-length-in-labor-induction-at-term
#18
REVIEW
Jessica Papillon-Smith, Haim A Abenhaim
The purpose of this study is to review the literature examining the role of ultrasound in the induction of labor. Databases including Ovid, PubMed, Web of Science, Google Scholar, and UpToDate were searched and current guidelines from the SOGC, the ACOG, the RCOG, and the RANZCOG were reviewed. Although studies have not demonstrated the superiority of cervical sonography to the Bishop score, the evidence indicates that sonography could be useful in planning induction of labor, significantly reducing the need for cervical ripening agents...
January 2015: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/24493079/conflict-of-interest-in-online-point-of-care-clinical-support-websites
#19
REVIEW
Kyle T Amber, Gaurav Dhiman, Kenneth W Goodman
Point-of-care evidence-based medicine websites allow physicians to answer clinical queries using recent evidence at the bedside. Despite significant research into the function, usability and effectiveness of these programmes, little attention has been paid to their ethical issues. As many of these sites summarise the literature and provide recommendations, we sought to assess the role of conflicts of interest in two widely used websites: UpToDate and Dynamed. We recorded all conflicts of interest for six articles detailing treatment for the following conditions: erectile dysfunction, fibromyalgia, hypogonadism, psoriasis, rheumatoid arthritis and Crohn's disease...
August 2014: Journal of Medical Ethics
https://www.readbyqxmd.com/read/23337215/cost-effectiveness-of-gene-expression-profiling-for-tumor-site-origin
#20
John Hornberger, Irina Degtiar, Hialy Gutierrez, Ashwini Shewade, W David Henner, Shawn Becker, Gauri Varadhachary, Gauri Varadachary, Stephen Raab
OBJECTIVES: Gene-expression profiling (GEP) reliably supplements traditional clinicopathological information on the tissue of origin (TOO) in metastatic or poorly differentiated cancer. A cost-effectiveness analysis of GEP TOO testing versus usual care was conducted from a US third-party payer perspective. METHODS: Data on recommendation changes for chemotherapy, surgery, radiation therapy, blood tests, imaging investigations, and hospice care were obtained from a retrospective, observational study of patients whose physicians received GEP TOO test results...
January 2013: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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