Małgorzata Dawidowska, Maria Kosmalska, Łukasz Sędek, Aleksandra Szczepankiewicz, Magdalena Twardoch, Alicja Sonsala, Bronisława Szarzyńska-Zawadzka, Katarzyna Derwich, Monika Lejman, Katarzyna Pawelec, Agnieszka Obitko-Płudowska, Katarzyna Pawińska-Wąsikowska, Kinga Kwiecińska, Andrzej Kołtan, Agnieszka Dyla, Władysław Grzeszczak, Jerzy R Kowalczyk, Tomasz Szczepański, Ewa Ziętkiewicz, Michał Witt
Minimal residual disease (MRD) enables reliable assessment of risk in acute lymphoblastic leukemia (ALL). However, little is known on association between MRD status and germline genetic variation. We examined 159 Caucasian (Slavic) patients with pediatric ALL, treated according to ALL-IC-BFM 2002/2009 protocols, in search for association between 23 germline polymorphisms and MRD status at day 15, day 33 and week 12, with adjustment for MRD-associated clinical covariates. Three variants were significantly associated with MRD: rs1544410 in VDR (MRD-day15); rs1051266 in RFC (MRD-day33, MRD-week12), independently and in an additive effect with rs10519613 in IL15 (MRD-day33)...
July 18, 2016: Scientific Reports