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JOURNAL ARTICLE
Dawn M E Bowdish, Vinod Chandran, Carol A Hitchon, Gilaad G Kaplan, J Antonio Avina-Zubieta, Paul R Fortin, Maggie J Larché, Gilles Boire, Anne-Claude Gingras, Roya M Dayam, Ines Colmegna, Luck Lukusa, Jennifer L F Lee, Dawn P Richards, Daniel Pereira, Tania H Watts, Mark S Silverberg, Charles N Bernstein, Diane Lacaille, Jenna Benoit, John Kim, Nadine Lalonde, Janet Gunderson, Hugues Allard-Chamard, Sophie Roux, Joshua Quan, Lindsay Hracs, Elizabeth Turnbull, Valeria Valerio, Sasha Bernatsky
OBJECTIVE: To determine how serologic responses to COVID vaccination/infection in immunemediated inflammatory disease (IMID) are affected by time since last vaccination and other factors. METHODS: Post-COVID-19 vaccination, data and dried blood spots/sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus, ankylosing spondylitis/spondylarthritis and psoriasis/psoriatic arthritis. First sample was at enrolment and then 2-4 weeks and 3, 6, and 12 months after latest vaccine dose...
April 15, 2024: Journal of Rheumatology
#22
JOURNAL ARTICLE
Dana A Weiss, Travis W Groth, Suhaib Abdulfattah Abdulfattah, Sahar Eftekharzadeh, Ted Lee, Richard Lee, Douglas A Canning, John V Kryger, Aseem R Shukla, Elizabeth B Roth, Michael E Mitchell, Joseph G Borer
BACKGROUND: Bladder exstrophy (BE) poses challenges both during the surgical repair and throughout follow-up. In 2013, a multi-institutional BE consortium was initiated, which included utilization of unified surgical principles for the complete primary repair of exstrophy (CPRE), real time coaching, ongoing video capture and review of video footage, prospective data collection, and routine patient data analysis, with the goal of optimizing the surgical procedure to minimize devastating complications such as glans ischemia and bladder dehiscence while maximizing the rate of volitional voiding with continence and long term protection of the upper tracts...
April 15, 2024: Journal of Urology
#23
JOURNAL ARTICLE
Edel Doyle, Lyndal Bugeja, Matthew R Dimmock, Kam L Lee, Jessica Ng, Richard B Bassed
PURPOSE: The skeletal survey X-ray series is the current 'gold standard' when investigating suspected physical abuse (SPA) of children, in addition to a non-contrast computed tomography (CT) brain scan. This systematic literature review synthesised findings of published research to determine if low dose computed tomography (LDCT) could detect subtle fractures and therefore replace the skeletal survey X-ray series in the investigation of SPA in children aged under 3 years. METHODS: Five electronic databases and grey literature were systematically searched from their inception to 28 April 2022...
April 15, 2024: International Journal of Legal Medicine
#24
JOURNAL ARTICLE
Michael A Petrie, Shauna Dudley-Javoroski, Kristin A Johnson, Jinhyun Lee, Olga Dubey, Richard K Shields
CONTEXT: Skeletal muscle has traditionally been considered a "force generator": necessary for purposes of locomotion, but expendable for non-ambulators who use wheelchairs, such as people with a spinal cord injury (SCI). Active skeletal muscle plays an indispensable role in regulating systemic metabolic functions, even in people with paralysis, but because of severe osteoporosis, high tetanic muscle forces induced with high frequency electrical stimulation may be risky for some individuals...
April 15, 2024: Journal of Spinal Cord Medicine
#25
JOURNAL ARTICLE
Dorthe B Berthelsen, Sabrina M Nielsen, Marianne U Rasmussen, Marieke Voshaar, Pamela Richards, Susan J Bartlett, Glen S Hazlewood, Beverly J Shea, Peter Tugwell, Torkell Ellingsen, Tanja S Jørgensen, Salome Kristensen, Lee S Simon, Robin Christensen, Caroline A Flurey
OBJECTIVES: There is growing interest in collecting outcome information directly from patients in clinical trials. This study evaluates what patients with rheumatic and musculoskeletal diseases (RMDs) consider important to know about symptomatic side effects they may experience from a new prescription drug. METHODS: Patients with inflammatory arthritis, who had one or more prescribed drugs for their disease for at least 12 months, participated in focus groups and individual interviews...
April 13, 2024: Rheumatology
#26
JOURNAL ARTICLE
Melissa H Lee, Judith Gooley, Varuni Obeyesekere, Jean Lu, Barbora Paldus, Christel Hendrieckx, Richard J MacIsaac, Sybil A McAuley, Jane Speight, Sara Vogrin, Alicia J Jenkins, D Jane Holmes-Walker, David N O'Neal, Glenn M Ward
BACKGROUND: Benefits of hybrid closed-loop (HCL) systems in a high-risk group with type 1 diabetes and impaired awareness of hypoglycemia (IAH) have not been well-explored. METHODS: Adults with Edmonton HYPO scores ≥1047 were randomized to 26-weeks HCL (MiniMed™ 670G) vs standard therapy (multiple daily injections or insulin pump) without continuous glucose monitoring (CGM) (control). Primary outcome was percentage CGM time-in-range (TIR; 70-180 mg/dL) at 23 to 26 weeks post-randomization...
April 13, 2024: Journal of Diabetes Science and Technology
#27
JOURNAL ARTICLE
Lee Hatter, Mark Holliday, Allie Eathorne, Pepa Bruce, Ian D Pavord, Helen K Reddel, Robert J Hancox, Alberto Papi, Mark Weatherall, Richard Beasley
INTRODUCTION: The use of pressurised metered-dose inhalers (pMDIs) and asthma exacerbations necessitating healthcare reviews contribute substantially to the global carbon footprint of healthcare. It is possible that a reduction in carbon footprint could be achieved by switching patients with mild asthma from salbutamol pMDI reliever therapy to inhaled corticosteroid-formoterol dry powder inhaler (DPI) reliever therapy, as recommended by the Global Initiative for Asthma (GINA). METHODS: This post hoc analysis included all 668 adult participants in the Novel START trial, who were randomised 1:1:1 to treatment with: as-needed budesonide-formoterol DPI, as-needed salbutamol pMDI, or maintenance budesonide DPI plus as-needed salbutamol pMDI...
April 12, 2024: European Respiratory Journal
#28
JOURNAL ARTICLE
Rita M Meganck, Caitlin E Edwards, Michael L Mallory, Rhianna E Lee, Hong Dang, Alexis B Bailey, Jason A Wykoff, Samuel C Gallant, Deanna R Zhu, Boyd L Yount, Takafumi Kato, Kendall M Shaffer, Satoko Nakano, Anne Marie Cawley, Vishwaraj Sontake, Jeremy R Wang, Robert S Hagan, Melissa B Miller, Purushothama Rao Tata, Scott H Randell, Longping V Tse, Camille Ehre, Kenichi Okuda, Richard C Boucher, Ralph S Baric
The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we dissect the complex selective pressures by evaluating variant fitness and adaptation in human respiratory tissues. We evaluate viral properties and host responses to reconstruct forces behind D614G through Omicron (BA.1) emergence. We observe differential replication in airway epithelia, differences in cellular tropism, and virus-induced cytotoxicity...
April 10, 2024: Cell Reports
#29
JOURNAL ARTICLE
Marcus A Urey, Benjamin Hibbert, Ulrich Jorde, Peter Eckman, Trevor Simard, Marino Labinaz, Babak Nazer, Mark Wiley, Bhanu Gupta, Andrew Sauer, Hirak Shah, Paul Sorajja, Andres M Pineda, Emil Missov, Ehtisham Mahmud, Rami Kahwash, Scott Lilly, Azeem Latib, Sandhya Murthy, Neil Fam, Santiago Garcia, Eugene S Chung, Liviu Klein, Richard Cheng, Brian A Houston, Nicholas S Amoroso, Lee Chang, Sameer Gafoor, Sunit-Preet Chaudhry, James Hermiller, Jonathan G Schwartz, Lillian Aldaia, Konstantinos Koulogiannis, William A Gray, Firas Zahr
AIMS: Patients with heart failure and mildly reduced or preserved ejection fraction have limited therapeutic options. The ALT-FLOW Early Feasibility Study evaluated safety, haemodynamics and outcomes for the APTURE transcatheter shunt system, a novel left atrium to coronary sinus shunt in these patients. METHODS AND RESULTS: Safety and shunt implantation success was evaluated for all 116 enrolled patients. An analysis population of implanted patients with a left ventricular ejection fraction (LVEF) >40% (n = 95) was chosen to assess efficacy via paired comparison between baseline and follow-up haemodynamic (3 and 6 months), and echocardiographic, clinical and functional outcomes (6 months and 1 year)...
April 12, 2024: European Journal of Heart Failure
#30
Lawrance Lee, Emaan Dawood, Gregory Vorona, Hope Richard, Nauman F Manzoor
No abstract text is available yet for this article.
April 4, 2024: American Journal of Otolaryngology
#31
JOURNAL ARTICLE
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela F J Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost...
2024: PLOS Glob Public Health
#32
JOURNAL ARTICLE
Adam G Culvenor, Thomas J West, Andrea M Bruder, Mark J Scholes, Christian J Barton, Ewa M Roos, Edwin H G Oei, Steven M McPhail, Richard B Souza, Jusuk Lee, Brooke E Patterson, Michael A Girdwood, Jamon L Couch, Kay M Crossley
OBJECTIVES: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. METHODS: The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4 )) 9-36 months post-ACLR...
2024: BMJ Open Sport & Exercise Medicine
#33
JOURNAL ARTICLE
Cameron D Thomas, Francesco Franchi, Joseph S Rossi, Ellen C Keeley, R David Anderson, Amber L Beitelshees, Julio D Duarte, Luis Ortega-Paz, Yan Gong, Richard A Kerensky, Natasha Kulick, Caitrin W McDonough, Anh B Nguyen, Yehua Wang, Marshall Winget, William E Yang, Julie A Johnson, Almut G Winterstein, George A Stouffer, Dominick J Angiolillo, Craig R Lee, Larisa H Cavallari
BACKGROUND: An ABCD-GENE (age, body mass index, chronic kidney disease, diabetes, and CYP2C19 genetic variants) score ≥10 predicts reduced clopidogrel effectiveness, but its association with response to alternative therapy remains unclear. OBJECTIVES: The aim of this study was to evaluate the association between ABCD-GENE score and the effectiveness of clopidogrel vs alternative P2Y12 inhibitor (prasugrel or ticagrelor) therapy after percutaneous coronary intervention (PCI)...
April 16, 2024: Journal of the American College of Cardiology
#34
JOURNAL ARTICLE
Seung Yup Lee, Brett C Bade, Cristina P Sison, Jason Karp, Matthew Inra, Subroto Paul, Paul Lee, Richard S Lazzaro, Rakesh Shah, Stuart L Cohen
OBJECTIVE: This study aims to determine if a novel imaging protocol (ultralow-dose dynamic expiratory computed tomography [CT] with repeated imaging) identifies tracheomalacia (TM) more reliably than traditional dynamic tracheal CT. METHODS: We performed a retrospective evaluation of 184 consecutive ultralow-dose dynamic CTs for TM during 2017. The protocol obtains images during 1 inspiration and 2 forced expirations. Tracheal narrowing during both expirations (airway narrowing [percentage] during first dynamic expiration CT [DE1], airway narrowing [percentage] during second dynamic expiration CT [DE2]) was reported as a percentage of inspiratory area...
April 10, 2024: Journal of Computer Assisted Tomography
#35
REVIEW
Samantha K F Kennedy, Shannon Goodall, Shing Fung Lee, Carlo DeAngelis, Allison Jocko, Flay Charbonneau, Katie Wang, Mark Pasetka, Yoo-Joung Ko, Henry C Y Wong, Adrian Wai Chan, Thenugaa Rajeswaran, Milena Gojsevic, Edward Chow, Richard J Gralla, Terry L Ng, Katarzyna J Jerzak
Chemotherapy-induced nausea and vomiting (CINV) is a common toxicity that may impair the quality of life of patients with various malignancies ranging from early to end stages. In light of frequent changes to the guidelines for optimal management of CINV, we undertook this narrative review to compare the most recent guidelines published by ASCO (2020), NCCN (2023), MASCC/ESMO (2023), and CCO (2019). The processes undertaken by each organization to evaluate existing literature were also described. Although ASCO, NCCN, MASCC/ESMO, and CCO guidelines for the treatment and prevention of CINV share many fundamental similarities, the literature surrounding low and minimal emetic risk regimens is lacking...
April 10, 2024: Supportive Care in Cancer
#36
JOURNAL ARTICLE
Tasmin Barry, Mark Holliday, Jenny Sparks, Rowan Biggs, Atalie Colman, Rebekah Lamb, Karen Oldfield, Nick Shortt, Kyley Kerse, John Martindale, Allie Eathorne, Michaela Walton, Bianca Black, Matire Harwood, Pepa Bruce, Ruth Semprini, Andrew Bush, Louise Fleming, Catherine A Byrnes, David McNamara, Lee Hatter, Stuart R Dalziel, Mark Weatherall, Richard Beasley
BACKGROUND: Asthma is the most common chronic childhood respiratory condition globally. Inhaled corticosteroid (ICS)-formoterol reliever-based regimens reduce the risk of asthma exacerbations compared with conventional short-acting β2 -agonist (SABA) reliever-based regimens in adults and adolescents. The current limited evidence for anti-inflammatory reliever therapy in children means it is unknown whether these findings are also applicable to children. High-quality randomised controlled trials (RCTs) are needed...
March 2024: ERJ Open Research
#37
JOURNAL ARTICLE
Lily D Yan, Rodney Sufra, Reichling St Sauveur, Marie Christine Jean-Pierre, Alexandra Apollon, Rodolphe Malebranche, Michel Théard, Gerard Pierre, Jessy Dévieux, Jennifer Lau, Nour Mourra, Nicholas L S Roberts, Rehana Rasul, Denis Nash, Altaf M Pirmohamed, Richard B Devereux, Myung Hee Lee, Gene F Kwan, Monika M Safford, Lauré Adrien, Jean Patrick Alfred, Marie Deschamps, Patrice Severe, Daniel W Fitzgerald, Jean W Pape, Vanessa Rouzier, Margaret L McNairy
BACKGROUND: Eighty percent of global cardiovascular disease (CVD) is projected to occur in low- and middle -income countries (LMICs), yet local epidemiological data are scarce. We provide the first population-based, adjudicated CVD prevalence estimates in Port-au-Prince, Haiti to describe the spectrum of heart disease and investigate associated risk factors. METHODS: Demographic, medical history, clinical, imaging and laboratory data were collected among adults recruited using multistage random sampling from 2019 to 2021...
May 2024: Lancet Reg Health Am
#38
JOURNAL ARTICLE
Yi-Hui Ou, Juliana Tereza Colpani, Crystal S Cheong, Weiqiang Loke, As Tar Thant, E Ching Shih, Frank Lee, Siew-Pang Chan, Ching-Hui Sia, Chieh-Yang Koo, Serene Wong, Aiping Chua, Chin-Meng Khoo, William Kong, Calvin W Chin, Pipin Kojodjojo, Philip E Wong, Mark Y Chan, A Mark Richards, Peter A Cistulli, Chi-Hang Lee
BACKGROUND: Hypertension guidelines recommend diagnosis and treatment of obstructive sleep apnea (OSA) in patients with hypertension. The mandibular advancement device (MAD) is an oral appliance therapy for patients who decline or cannot tolerate CPAP. OBJECTIVE: We compared the relative effectiveness of MAD versus CPAP in reducing 24-hour ambulatory BP. METHODS: In an investigator-initiated, randomized, non-inferiority trial (pre-specified margin 1...
March 13, 2024: Journal of the American College of Cardiology
#39
JOURNAL ARTICLE
Samantha Guinn, Benedict Kinny-Köster, Joseph A Tandurella, Jacob T Mitchell, Dimitrios N Sidiropoulos, Melanie Loth, Melissa R Lyman, Alexandra B Pucsek, Daniel J Zabransky, Jae W Lee, Emma Kartalia, Mili Ramani, Toni T Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L Wolfgang, Jun Yu, Lei Zheng, David P Ryan, David T Ting, Alec C Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H Elisseeff, Laura D Wood, Genevieve Stein-O'Brien, Luciane T Kagohara, Elizabeth M Jaffee, Richard A Burkhart, Elana J Fertig, Jacquelyn W Zimmerman
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with cancer associated fibroblasts (CAFs). This study utilized a convergence approach to identify tumor cell and CAF interactions through the integration of single-cell data from human tumors with human organoid co-culture experiments. Analysis of a comprehensive atlas of PDAC single-cell RNA sequencing (scRNA-seq) data indicated that CAF density is associated with increased inflammation and epithelial-mesenchymal transition (EMT) in epithelial cells...
April 8, 2024: Cancer Research
#40
JOURNAL ARTICLE
Yue Zhou, Gregory A Phelps, Mikayla M Mangrum, Jemma McLeish, Elise K Phillips, Jinchao Lou, Christelle F Ancajas, Jeffrey M Rybak, Peter M Oelkers, Richard E Lee, Michael D Best, Todd B Reynolds
UNLABELLED: Systemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida albicans is a logical antifungal drug target due to its importance in virulence, absence in the host, and conservation among fungal pathogens. Inhibitors of Cho1 could serve as lead compounds for drug development, so we developed a target-based screen for inhibitors of purified Cho1...
April 9, 2024: MBio
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