keyword
MENU ▼
Read by QxMD icon Read
search

Richard Lee

keyword
https://www.readbyqxmd.com/read/29233214/microdroplet-fusion-mass-spectrometry-accelerated-kinetics-of-acid-induced-chlorophyll-demetallation
#1
Jae Kyoo Lee, Hong Gil Nam, Richard N Zare
Kinetics of acid-induced chlorophyll demetallation was recorded in microdroplets by fusing a stream of microdroplets containing 40 µM chlorophyll a or b dissolved in methanol with a stream of aqueous microdroplets containing 35 mM hydrochloric acid (pH = 1·46). The kinetics of the demetallation of chlorophyll in the fused microdroplets (14 ± 6 µm diameter; 84 ± 18 m s-1 velocity) was recorded by controlling the traveling distance of the fused microdroplets between the fusion region and the inlet of a mass spectrometer...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29229836/single-cell-analysis-resolves-the-cell-state-transition-and-signaling-dynamics-associated-with-melanoma-drug-induced-resistance
#2
Yapeng Su, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, Jungwoo Kim, Rachel H Ng, Jihoon W Lee, Richard C Koya, Begonya Comin-Anduix, Thomas G Graeber, Antoni Ribas, James R Heath
Continuous BRAF inhibition of BRAF mutant melanomas triggers a series of cell state changes that lead to therapy resistance and escape from immune control before establishing acquired resistance genetically. We used genome-wide transcriptomics and single-cell phenotyping to explore the response kinetics to BRAF inhibition for a panel of patient-derived BRAFV600 -mutant melanoma cell lines. A subset of plastic cell lines, which followed a trajectory covering multiple known cell state transitions, provided models for more detailed biophysical investigations...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229464/a-single-institution-retrospective-review-of-335-celect-platinum-inferior-vena-cava-filter-placements
#3
Brian E Lee, Richard J Van Allan, Marc L Friedman, H Gabriel Lipshutz
BACKGROUND: The purpose of this study was to retrospectively assess the retrieval characteristics and rate of filter-related complications associated with use of the Celect Platinum (Cook Medical, Bloomington, Ind) inferior vena cava filter (IVCF). METHODS: A single-center, retrospective review was conducted to identify patients who received a Celect Platinum IVCF between June 2013 and February 2016. The patients' charts and imaging records (computed tomography [CT] and cavography) associated with filter placement, follow-up, and filter retrieval procedures were assessed for attempted and successful retrieval rates and filter-related complications...
December 8, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29229113/measuring-voluntary-and-reflexive-cough-strength-in-healthy-individuals
#4
Claire Mills, Richard Jones, Maggie-Lee Huckabee
BACKGROUND: Cough reflex testing is a validated tool for identifying patients at risk of silent aspiration. However, inter- and intra-rater reliabilities of perceptual judgements of cough strength are sub-optimal. Although there are clinically established methods for measuring volitional cough strength, no similar methods are identified for reflexive cough strength. This study evaluated three measurement methods of voluntary and suppressed reflexive cough strength. METHODS: Fifty-three healthy subjects (≥50 years) participated in this study...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29227286/drug-perturbation-based-stratification-of-blood-cancer
#5
Sascha Dietrich, Małgorzata Oleś, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Hüllein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K Oleś, Mikołaj Słabicki, Andreas Mock, Christopher C Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D Ho, Manfred Hensel, Jan Dürig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29223478/phase-ii-trial-of-veliparib-in-patients-with-previously-treated-brca-mutated-pancreas-ductal-adenocarcinoma
#6
Maeve A Lowery, David P Kelsen, Marinela Capanu, Sloane C Smith, Jonathan W Lee, Zsofia K Stadler, Malcolm J Moore, Hedy L Kindler, Talia Golan, Amiel Segal, Hannah Maynard, Ellen Hollywood, MaryEllen Moynahan, Erin E Salo-Mullen, Richard Kinh Gian Do, Alice P Chen, Kenneth H Yu, Laura H Tang, Eileen M O'Reilly
PURPOSE: BRCA-associated cancers have increased sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis). This single arm, non-randomised, multicentre phase II trial evaluated the response rate of veliparib in patients with previously treated BRCA1/2- or PALB2-mutant pancreatic adenocarcinoma (PDAC). METHODS: Patients with stage III/IV PDAC and known germline BRCA1/2 or PALB2 mutation, 1-2 lines of treatment, Eastern Cooperative Oncology Group 0-2, were enrolled...
December 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29220675/exome-wide-association-study-identifies-greb1l-mutations-in-congenital-kidney-malformations
#7
Simone Sanna-Cherchi, Kamal Khan, Rik Westland, Priya Krithivasan, Lorraine Fievet, Hila Milo Rasouly, Iuliana Ionita-Laza, Valentina P Capone, David A Fasel, Krzysztof Kiryluk, Sitharthan Kamalakaran, Monica Bodria, Edgar A Otto, Matthew G Sampson, Christopher E Gillies, Virginia Vega-Warner, Katarina Vukojevic, Igor Pediaditakis, Gabriel S Makar, Adele Mitrotti, Miguel Verbitsky, Jeremiah Martino, Qingxue Liu, Young-Ji Na, Vinicio Goj, Gianluigi Ardissino, Maddalena Gigante, Loreto Gesualdo, Magdalena Janezcko, Marcin Zaniew, Cathy Lee Mendelsohn, Shirlee Shril, Friedhelm Hildebrandt, Joanna A E van Wijk, Adela Arapovic, Marijan Saraga, Landino Allegri, Claudia Izzi, Francesco Scolari, Velibor Tasic, Gian Marco Ghiggeri, Anna Latos-Bielenska, Anna Materna-Kiryluk, Shrikant Mane, David B Goldstein, Richard P Lifton, Nicholas Katsanis, Erica E Davis, Ali G Gharavi
No abstract text is available yet for this article.
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29220013/corrigendum-in-vivo-genome-editing-and-organoid-transplantation-models-of-colorectal-cancer-and-metastasis
#8
Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian, Steffen Rickelt, Mohammad Almeqdadi, Katherine Wu, Matthias A Oberli, Francisco Sánchez-Rivera, Yoona K Park, Xu Liang, George Eng, Martin S Taylor, Roxana Azimi, Dmitriy Kedrin, Rachit Neupane, Semir Beyaz, Ewa T Sicinska, Yvelisse Suarez, James Yoo, Lillian Chen, Lawrence Zukerberg, Pekka Katajisto, Vikram Deshpande, Adam J Bass, Philip N Tsichlis, Jacqueline Lees, Robert Langer, Richard O Hynes, Jianzhu Chen, Arjun Bhutkar, Tyler Jacks, Ömer H Yilmaz
This corrects the article DOI: 10.1038/nbt.3836.
December 8, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29218517/glucose-uptake-in-heterologous-expression-systems
#9
Eunice E Lee, Richard C Wang
Understanding the physiological regulation of glucose transport requires the analysis of transporters, like GLUT1, in diverse tissue types. We document the utility of viral vectors for the stable expression of wild-type and modified GLUT1 transporter in different types of mammalian cells. Once expression of the alleles has been confirmed by Western blotting, the effect of specific mutations on the regulation of glucose transport can be measured through a previously described radiolabeled glucose transport assay...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29215506/can-early-patient-reported-outcomes-be-used-to-identify-patients-at-risk-for-poor-1-year-health-outcomes-after-lumbar-laminectomy-with-arthrodesis
#10
Taylor E Purvis, Brian J Neuman, Lee H Riley, Richard L Skolasky
STUDY DESIGN: Prospective cohort. OBJECTIVE: Determine 1) between-patient variability in patient-reported outcomes (PROs) at 4 postoperative time points; 2) within-patient correlation of 1-year PROs with PROs at 3 earlier time points; and 3) ability of early PROs to predict 1-year PROs after lumbar laminectomy with arthrodesis. SUMMARY OF BACKGROUND DATA: It is unclear whether early PROs can help identify patients at risk for poor health outcomes...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29215200/mir-424-5p-reduces-ribosomal-rna-and-protein-synthesis-in-muscle-wasting
#11
Martin Connolly, Richard Paul, Roser Farre-Garros, Samantha A Natanek, Susannah Bloch, Jen Lee, Jose P Lorenzo, Harnish Patel, Cyrus Cooper, Avan A Sayer, Stephen J Wort, Mark Griffiths, Michael I Polkey, Paul R Kemp
BACKGROUND: A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to anabolic stimulation often reported features. Ribosomes are required for protein synthesis, so changes in the control of ribosome synthesis are potential contributors to muscle wasting. MicroRNAs (miRNAs) are known regulators of muscle phenotype and have been shown to modulate components of the protein synthetic pathway...
December 7, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29214234/magnetic-sensing-potential-of-fe3o4-nanocubes-exceeds-that-of-fe3o4-nanospheres
#12
Arati G Kolhatkar, Yi-Ting Chen, Pawilai Chinwangso, Ivan Nekrashevich, Gamage C Dannangoda, Ankit Singh, Andrew C Jamison, Oussama Zenasni, Irene A Rusakova, Karen S Martirosyan, Dmitri Litvinov, Shoujun Xu, Richard C Willson, T Randall Lee
This paper highlights the relation between the shape of iron oxide (Fe3O4) particles and their magnetic sensing ability. We synthesized Fe3O4 nanocubes and nanospheres having tunable sizes via solvothermal and thermal decomposition synthesis reactions, respectively, to obtain samples in which the volumes and body diagonals/diameters were equivalent. Vibrating sample magnetometry (VSM) data showed that the saturation magnetization (Ms) and coercivity of 100-225 nm cubic magnetic nanoparticles (MNPs) were, respectively, 1...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29213322/deletion-of-the-hfsb-gene-increases-ethanol-production-in-thermoanaerobacterium-saccharolyticum-and-several-other-thermophilic-anaerobic-bacteria
#13
Ayşenur Eminoğlu, Sean Jean-Loup Murphy, Marybeth Maloney, Anthony Lanahan, Richard J Giannone, Robert L Hettich, Shital A Tripathi, Ali Osman Beldüz, Lee R Lynd, Daniel G Olson
Background: With the discovery of interspecies hydrogen transfer in the late 1960s (Bryant et al. in Arch Microbiol 59:20-31, 1967), it was shown that reducing the partial pressure of hydrogen could cause mixed acid fermenting organisms to produce acetate at the expense of ethanol. Hydrogen and ethanol are both more reduced than glucose. Thus there is a tradeoff between production of these compounds imposed by electron balancing requirements; however, the mechanism is not fully known...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29210922/splenda%C3%A2-in-the-milk-hitting-the-sweet-spot
#14
Richard Thomas Lee Couper
No abstract text is available yet for this article.
November 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29208994/author-correction-the-global-distribution-of-tetrapods-reveals-a-need-for-targeted-reptile-conservation
#15
Uri Roll, Anat Feldman, Maria Novosolov, Allen Allison, Aaron M Bauer, Rodolphe Bernard, Monika Böhm, Fernando Castro-Herrera, Laurent Chirio, Ben Collen, Guarino R Colli, Lital Dabool, Indraneil Das, Tiffany M Doan, Lee L Grismer, Marinus Hoogmoed, Yuval Itescu, Fred Kraus, Matthew LeBreton, Amir Lewin, Marcio Martins, Erez Maza, Danny Meirte, Zoltán T Nagy, Cristiano de C Nogueira, Olivier S G Pauwels, Daniel Pincheira-Donoso, Gary D Powney, Roberto Sindaco, Oliver Tallowin, Omar Torres-Carvajal, Jean-François Trape, Enav Vidan, Peter Uetz, Philipp Wagner, Yuezhao Wang, C David L Orme, Richard Grenyer, Shai Meiri
No abstract text is available yet for this article.
December 5, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29203526/caveolin-1-regulates-lipid-droplet-metabolism-in-endothelial-cells-via-autocrine-prostacyclin-stimulated-camp-mediated-lipolysis
#16
Andrew Kuo, Monica Y Lee, Kui Yang, Richard W Gross, William C Sessa
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in almost all eukaryotic cells and LD associated proteins tightly regulate their dynamics. One LD coat proteins is caveolin-1 (Cav-1), an essential component for caveolae assembly in highly differentiated cells including adipocytes, smooth muscle cells and endothelial cells (EC). However, the role of Cav-1 in LD dynamics is unclear. Here, we report that EC lacking Cav-1 exhibit impaired LD formation. The decreased LD formation was due to due to enhanced  lipolysis, and not caused by reduced triglyceride synthesis or fatty acid uptake...
December 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29203215/transapical-mitral-replacement-with-anterior-leaflet-splitting-a-novel-technique-to-avoid-left-ventricular-outflow-tract-obstruction
#17
Richard Lee, Dawn S Hui, Tarek A Helmy, Michael J Lim
No abstract text is available yet for this article.
October 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29202230/the-forbidden-11bu-excited-singlet-state-in-peridinin-and-peridinin-analogues
#18
Jordan A Greco, Nicole Lee Wagner, Harry A Frank, Robert Richards Birge
Theoretical studies have predicted the presence of a forbidden 11Bu- state in proximity to the strongly-allowed 11Bu+ excited state in polyenes and carotenoids. The 11Bu- state is invariably predicted to have a very low oscillator strength, which precludes direct optical spectroscopic assignment. We report here a direct UV-visible optical spectroscopic feature assigned to the 11Bu- state of S-2-peridinin, a synthetic analogue of the naturally-occurring carotenoid, peridinin. The shift of the ground state dipole of S-2-peridinin compared to natural peridinin enhances the oscillator strength of absorption from the ground state to the 11Bu- state by two orders of magnitude relative to peridinin...
December 4, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29200092/practical-considerations-in-use-of-trigger-tool-methodology-in-the-emergency-department
#19
Richard T Griffey, Ryan M Schneider, Brian R Sharp, Marie C Vrablik, Lee Adler
No abstract text is available yet for this article.
December 1, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29198805/the-quality-of-quality-assessment-after-atrial-fibrillation-surgery
#20
EDITORIAL
Dawn S Hui, Richard Lee
No abstract text is available yet for this article.
October 27, 2017: Journal of Thoracic and Cardiovascular Surgery
keyword
keyword
120585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"