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Richard Lee

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https://www.readbyqxmd.com/read/29691297/validation-of-a-plasma-based-comprehensive-cancer-genotyping-assay-utilizing-orthogonal-tissue-and-plasma-based-methodologies
#1
Justin I Odegaard, John J Vincent, Stefanie Mortimer, James V Vowles, Bryan C Ulrich, Kimberly C Banks, Stephen R Fairclough, Oliver A Zill, Marcin Sikora, Reza Mokhtari, Diana Abdueva, Rebecca J Nagy, Christine E Lee, Lesli A Kiedrowski, Cloud P Paweletz, Helmy Eltoukhy, Richard B Lanman, Darya I Chudova, AmirAli Talasaz
PURPOSE: Liquid biopsies are powerful tools that enable non-invasive genotyping of advanced solid tumors; however, comprehensive, structured validation studies employing validated orthogonal comparator methods are lacking. EXPERIMENTAL DESIGN: Analytical validation was conducted according to established principles and guidelines. Blood-to-blood clinical validation comprised blinded external comparison to clinical digital droplet PCR across 222 consecutive biomarker-positive clinical samples...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29688843/cost-of-medical-care-of-patients-with-advanced-serious-illness-in-singapore-compass-prospective-cohort-study-protocol
#2
Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang, Patricia Soek Hui Neo, Nivedita V Nadkarni, Richard Harding, Eric A Finkelstein
BACKGROUND: Advanced cancer significantly impacts quality of life of patients and families as they cope with symptom burden, treatment decision-making, uncertainty and costs of treatment. In Singapore, information about the experiences of advanced cancer patients and families and the financial cost they incur for end-of-life care is lacking. Understanding of this information is needed to inform practice and policy to ensure continuity and affordability of care at the end of life. The primary objectives of the Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS) cohort study are to describe changes in quality of life and to quantify healthcare utilization and costs of patients with advanced cancer at the end of life...
April 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29683845/adverse-fetal-and-infant-outcomes-among-hiv-infected-women-who-received-either-nnrti-or-pi-based-art-for-pmtct
#3
Rose Masaba, Craig B Borkowf, Sonali Girde, Clement Zeh, Richard Ndivo, Isabella Nyang'au, Kevin Achola, Timothy K Thomas, Shirley Lee Lecher
BACKGROUND: For HIV-infected pregnant and breastfeeding women, antiretroviral therapy (ART) is known to reduce the mother's risk of passing the infection to her child. However, concerns remain about possible associations between various components of different ART regimens and adverse fetal and infant outcomes. As part of a clinical trial in western Kenya for the prevention of mother-to-child transmission (PMTCT) of HIV, pregnant women received one of two different ART regimens. METHODS: The original PMTCT study conducted in Kenya enrolled 522 HIV-infected, ART-naïve pregnant women...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29681454/chemistry-first-approach-for-nomination-of-personalized-treatment-in-lung-cancer
#4
Elizabeth A McMillan, Myung-Jeom Ryu, Caroline H Diep, Saurabh Mendiratta, Jean R Clemenceau, Rachel M Vaden, Ju-Hwa Kim, Takashi Motoyaji, Kyle R Covington, Michael Peyton, Kenneth Huffman, Xiaofeng Wu, Luc Girard, Yeojin Sung, Pei-Hsaun Chen, Prema L Mallipeddi, Joo Young Lee, Jordan Hanson, Sukesh Voruganti, Yunku Yu, Sunho Park, Jessica Sudderth, Christopher DeSevo, Donna M Muzny, HarshaVardhan Doddapaneni, Adi Gazdar, Richard A Gibbs, Tae-Hyun Hwang, John V Heymach, Ignacio Wistuba, Kevin R Coombes, Noelle S Williams, David A Wheeler, John B MacMillan, Ralph J Deberardinis, Michael G Roth, Bruce A Posner, John D Minna, Hyun Seok Kim, Michael A White
Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing challenge is the development of drugs that target patient-specific disease mechanisms. To address this challenge, we employed a chemistry-first discovery paradigm for de novo identification of druggable targets linked to robust patient selection hypotheses. In particular, a 200,000 compound diversity-oriented chemical library was profiled across a heavily annotated test-bed of >100 cellular models representative of the diverse and characteristic somatic lesions for lung cancer...
April 11, 2018: Cell
https://www.readbyqxmd.com/read/29676392/integrated-genomic-analyses-of-de-novo-pathways-underlying-atypical-meningiomas
#5
Akdes Serin Harmancı, Mark W Youngblood, Victoria E Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E Zeynep Erson-Omay, Leon D Kaulen, Tong Ihn Lee, Brian J Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
This corrects the article DOI: 10.1038/ncomms14433.
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674623/spontaneous-formation-of-gold-nanostructures-in-aqueous-microdroplets
#6
Jae Kyoo Lee, Devleena Samanta, Hong Gil Nam, Richard N Zare
The synthesis of gold nanostructures has received widespread attention owing to many important applications. We report the accelerated synthesis of gold nanoparticles (AuNPs), as well as the reducing-agent-free and template-free synthesis of gold nanoparticles and nanowires in aerosol microdroplets. At first, the AuNP synthesis are carried out by fusing two aqueous microdroplet streams containing chloroauric acid and sodium borohydride. The AuNPs (~7 nm in diameter) are produced within 60 µs at the rate of 0...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674334/p-wave-amplitude-and-pr-changes-in-patients-with-inappropriate-sinus-tachycardia-findings-supportive-of-a-central-mechanism
#7
Michael E Field, Paolo Donateo, Nicola Bottoni, Matteo Iori, Michele Brignole, Ryan T Kipp, Douglas E Kopp, Miguel A Leal, Lee L Eckhardt, Jennifer M Wright, Kathleen E Walsh, Richard L Page, Mohamed H Hamdan
BACKGROUND: The mechanism of inappropriate sinus tachycardia (IST) remains incompletely understood. METHODS AND RESULTS: We prospectively compared 3 patient groups: 11 patients with IST (IST Group), 9 control patients administered isoproterenol (Isuprel Group), and 15 patients with cristae terminalis atrial tachycardia (AT Group). P-wave amplitude in lead II and PR interval were measured at a lower and higher heart rate (HR1 and HR2, respectively). P-wave amplitude increased significantly with the increase in HR in the IST Group (0...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29674228/error-analysis-of-speed-of-sound-reconstruction-in-ultrasound-limited-angle-transmission-tomography
#8
Rungroj Jintamethasawat, Won-Mean Lee, Paul L Carson, Fong Ming Hooi, J Brian Fowlkes, Mitchell M Goodsitt, Richard Sampson, Thomas F Wenisch, Siyuan Wei, Jian Zhou, Chaitali Chakrabarti, Oliver D Kripfgans
We have investigated limited angle transmission tomography to estimate speed of sound (SOS) distributions for breast cancer detection. That requires both accurate delineations of major tissues, in this case by segmentation of prior B-mode images, and calibration of the relative positions of the opposed transducers. Experimental sensitivity evaluation of the reconstructions with respect to segmentation and calibration errors is difficult with our current system. Therefore, parametric studies of SOS errors in our bent-ray reconstructions were simulated...
April 7, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29671186/the-role-of-randomized-cluster-crossover-trials-for-comparative-effectiveness-testing-in-anesthesia-design-of-the-benzodiazepine-free-cardiac-anesthesia-for-reduction-in-postoperative-delirium-b-free-trial
#9
Jessica Spence, Emilie Belley-Côté, Shun Fu Lee, Shrikant Bangdiwala, Richard Whitlock, Yannick LeManach, Summer Syed, Andre Lamy, Eric Jacobsohn, Sarah MacIsaac, P J Devereaux, Stuart Connolly
Increasingly, clinicians and researchers recognize that studies of interventions need to evaluate not only their therapeutic efficacy (i.e., the effect on an outcome in ideal, controlled settings) but also their real-world effectiveness in broad, unselected patient groups. Effectiveness trials inform clinical practice by comparing variations in therapeutic approaches that fall within the standard of care. In this article, we discuss the need for studies of comparative effectiveness in anesthesia and the limitations of individual patient randomized-controlled trials in determining comparative effectiveness...
April 18, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29670280/mechanism-of-nmda-receptor-channel-block-by-mk-801-and-memantine
#10
Xianqiang Song, Morten Ø Jensen, Vishwanath Jogini, Richard A Stein, Chia-Hsueh Lee, Hassane S Mchaourab, David E Shaw, Eric Gouaux
The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well understood. Here we show that removal of the amino-terminal domains from the GluN1-GluN2B NMDA receptor yields a functional receptor and crystals with good diffraction properties, allowing us to map the binding site of the NMDA receptor blocker, MK-801...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29669917/ribosomal-dna-copy-loss-and-repeat-instability-in-atrx-mutated-cancers
#11
Maheshi Udugama, Elaine Sanij, Hsiao P J Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona T M Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong
ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion of ATRX in mouse ES cells leads to selective loss in ribosomal RNA gene (rDNA) copy number. Supporting this, ATRX-mutated human ALT-positive tumors also show a substantially lower rDNA copy than ALT-negative tumors...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29669751/hip-synovial-fluid-cell-counts-in-children-from-a-lyme-disease-endemic-area
#12
Arianna H Dart, Kenneth A Michelson, Paul L Aronson, Aris C Garro, Thomas J Lee, Kimberly M Glerum, Peter A Nigrovic, Mininder S Kocher, Richard G Bachur, Lise E Nigrovic
BACKGROUND: Patients with septic hip arthritis require surgical drainage, but they can be difficult to distinguish from patients with Lyme arthritis. The ability of synovial fluid white blood cell (WBC) counts to help discriminate between septic and Lyme arthritis of the hip has not been investigated. METHODS: We assembled a retrospective cohort of patients ≤21 years of age with hip monoarticular arthritis and a synovial fluid culture obtained who presented to 1 of 3 emergency departments located in Lyme disease endemic areas...
April 18, 2018: Pediatrics
https://www.readbyqxmd.com/read/29667911/experimental-heat-stress-nephropathy-and-liver-injury-are-improved-by-allopurinol
#13
Carlos A Roncal-Jimenez, Yuka Sato, Tamara Milagres, Ana Andres-Hernando, Gabriela E Garcia, Petter Bjornstad, Jaime Butler-Dawson, Cecilia Sorensen, Lee Newman, Lyndsay Krisher, Magdalena Madero, Jason Glaser, Ramon Garcia-Trabannino, Emmanuel Jarquin-Romero, Zhilin Song, Thomas Jensen, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Laura-Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson
BACKGROUND: An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be caused by recurrent heat stress and dehydration, and potentially by hyperuricemia. Accordingly, we developed a murine model of kidney injury associated with recurrent heat stress. In the current experiment, we tested whether treatment with allopurinol (a xanthine oxidase inhibitor that reduces serum urate) provides renal protection against recurrent heat stress and dehydration...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667907/direct-peritoneal-resuscitation-reduces-leukocyte-infiltration-in-the-kidney-after-acute-brain-death
#14
Jessica Lee Weaver, Paul J Matheson, Amy Matheson, Victoria S Graham, Cynthia Downard, Richard Neal Garrison, Jason W Smith
Brain death is associated with significant inflammation within the kidneys, which may contribute to reduced graft survival. Direct peritoneal resuscitation (DPR) has been shown to reduce systemic inflammation after brain death. To determine its effects, brain dead rats were resuscitated with normal saline (targeted intravenous fluid, TIVF) to maintain a mean arterial pressure of 80 mmHg and DPR animals also received 30cc of intraperitoneal peritoneal dialysis solution. Rats were euthanized at zero, two, four, and six hours after brain death...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29665324/rapid-amplification-of-prions-from-variant-creutzfeldt-jakob-disease-cerebrospinal-fluid
#15
Marcelo A Barria, Andrew Lee, Alison Je Green, Richard Knight, Mark W Head
Human prion diseases constitute a group of infectious and invariably fatal neurodegenerative disorders associated with misfolding of the prion protein. Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease linked to oral exposure to the infectious agent that causes bovine spongiform encephalopathy (BSE) in cattle. The most recent case of definite vCJD was heterozygous (MV) at polymorphic codon 129 of the prion protein gene PRNP while all of the previous 177 definite or probable vCJD cases who underwent genetic analysis were methionine homozygous (MM)...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29665244/dafi-a-directed-recursive-data-filtering-and-clustering-approach-for-improving-and-interpreting-data-clustering-identification-of-cell-populations-from-polychromatic-flow-cytometry-data
#16
Alexandra J Lee, Ivan Chang, Julie G Burel, Cecilia S Lindestam Arlehamn, Aishwarya Mandava, Daniela Weiskopf, Bjoern Peters, Alessandro Sette, Richard H Scheuermann, Yu Qian
Computational methods for identification of cell populations from polychromatic flow cytometry data are changing the paradigm of cytometry bioinformatics. Data clustering is the most common computational approach to unsupervised identification of cell populations from multidimensional cytometry data. However, interpretation of the identified data clusters is labor-intensive. Certain types of user-defined cell populations are also difficult to identify by fully automated data clustering analysis. Both are roadblocks before a cytometry lab can adopt the data clustering approach for cell population identification in routine use...
April 17, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29663278/impact-of-teaching-intensity-and-sociodemographic-characteristics-on-cms-hospital-compare-quality-ratings
#17
Wenshuai Wan, C Jason Liang, Richard Duszak, Christoph I Lee
No abstract text is available yet for this article.
April 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29662249/managing-for-multifunctionality-in-perennial-grain-crops
#18
Matthew R Ryan, Timothy E Crews, Steven W Culman, Lee R DeHaan, Richard C Hayes, Jacob M Jungers, Matthew G Bakker
Plant breeders are increasing yields and improving agronomic traits in several perennial grain crops, the first of which is now being incorporated into commercial food products. Integration strategies and management guidelines are needed to optimize production of these new crops, which differ substantially from both annual grain crops and perennial forages. To offset relatively low grain yields, perennial grain cropping systems should be multifunctional. Growing perennial grains for several years to regenerate soil health before rotating to annual crops and growing perennial grains on sloped land and ecologically sensitive areas to reduce soil erosion and nutrient losses are two strategies that can provide ecosystem services and support multifunctionality...
April 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29662201/differential-glucose-requirement-in-skin-homeostasis-and-injury-identifies-a-therapeutic-target-for-psoriasis
#19
Zhuzhen Zhang, Zhenzhen Zi, Eunice E Lee, Jiawei Zhao, Diana C Contreras, Andrew P South, E Dale Abel, Benjamin F Chong, Travis Vandergriff, Gregory A Hosler, Philipp E Scherer, Marcel Mettlen, Jeffrey C Rathmell, Ralph J DeBerardinis, Richard C Wang
Proliferating cells, compared with quiescent cells, are more dependent on glucose for their growth. Although glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, we found that keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. Ex vivo metabolic profiling revealed altered sphingolipid, hexose, amino acid, and nucleotide metabolism in Glut1-deficient keratinocytes, thus suggesting metabolic adaptation. However, cultured Glut1-deficient keratinocytes displayed metabolic and oxidative stress and impaired proliferation...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29660514/early-life-predictors-of-brain-development-at-term-equivalent-age-in-infants-born-across-the-gestational-age-spectrum
#20
REVIEW
Deanne K Thompson, Claire E Kelly, Jian Chen, Richard Beare, Bonnie Alexander, Marc L Seal, Katherine Lee, Lillian G Matthews, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong
BACKGROUND: It is well established that preterm infants have altered brain development compared with full-term (FT; ≥37 weeks' gestational age [GA]) infants, however the perinatal factors associated with brain development in preterm infants have not been fully elucidated. In particular, perinatal predictors of brain development may differ between very preterm infants (VP; <32 weeks' GA) and infants born moderate (MP; 32-33 weeks' GA) and late (LP; 34-36 weeks' GA) preterm, but this has not been studied...
April 13, 2018: NeuroImage
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