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phaeohyphomycosis

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https://www.readbyqxmd.com/read/29119669/sinusitis-caused-by-exserohilum-rostratum-after-cord-blood-transplantation-for-myelodysplastic-syndrome-a-case-report-and-literature-review
#1
Sumiko Kohashi, Takaaki Toyama, Norisato Hashimoto, Masatoshi Sakurai, Jun Kato, Taku Kikuchi, Yuya Koda, Kayoko Sugita, Naoki Hasegawa, Kyoko Yarita, Katsuhiko Kamei, Shinichiro Okamoto, Takehiko Mori
Invasive fungal disease is a serious infectious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Exserohilum rostratum is a species causing phaeohyphomycosis, which rarely causes invasive disease in humans. We treated a case of sinusitis caused by E. rostratum after cord blood transplantation (CBT). A 60-year-old man with myelodysplastic syndrome, who had a medical history of an operation to correct deviation of the nasal septum, developed sinusitis caused by E. rostratum under prolonged profound neutropenia after a second CBT because of the graft rejection of the first transplantation...
November 8, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29080677/impaired-specific-anti-fungal-immunity-in-card9-deficient-patients-with-phaeohyphomycosis
#2
Xiaowen Wang, Ruijun Zhang, Weiwei Wu, Yinggai Song, Zhe Wan, Wenling Han, Ruoyu Li
Phaeohyphomycosis is a group of severe infections caused by dematiaceous fungi. We previously identified CARD9 deficiencies in four Chinese patients with phaeohyphomycosis caused by Phialophora verrucosa. In this study, we sought to identify the genetic and immunological mechanisms underlying rare dematiaceous fungal infections in three otherwise healthy patients with phaeohyphomycosis caused by Exophiala spinifera, Ochroconis musae, and Corynespora cassiicola. CARD9 sequencing in these patients revealed one novel mutation (p...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29018005/the-clinical-presentation-of-subcutaneous-phaeohyphomycosis-a-case-series-from-yetebon-ethiopia
#3
Rachel B Kang, Devin C Simonson, Sarah E Stoner, William A Agger
Subcutaneous phaeohyphomycosis is a chronic fungal infection usually found on the lower extremity and feet of agricultural workers in the tropics. It can present with various skin manifestations, verrucous to nodular plaques, and is caused by multiple species of fungi. Laboratory confirmation requires skin samples for pathology and fungal cultures. Cure, often difficult in resource-poor countries, requires months of antifungal therapy. We describe the cases of 3 men from Ethiopia who were seen and are being treated by American doctors who traveled there on a medical mission...
October 10, 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28994224/rare-and-unusual-presentation-of-cladophialophora-infection-in-a-pulmonary-transplant-cystic-fibrosis-patient
#4
Quitterie Reynaud, Damien Dupont, Raphaële Nove-Josserand, Stephane Durupt, Florence Persat, Florence Ader, Dominique Grenet, Isabelle Durieu
A 35-year-old woman with severe cystic fibrosis was admitted for sudden loss of strength in both legs, revealing a myelitis. The medullar lesion biopsy revealed phaeohyphomycosis caused by Cladophialophora species. Myelitis caused by Cladophialophora bantiana is a rare disease associated with high mortality. This article is protected by copyright. All rights reserved.
October 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28994174/subcutaneous-phaeohyphomycosis-in-kidney-transplant-recipients-a-series-of-seven-cases
#5
Haridasan Satish, Sreejith Parameswaran, B H Srinivas, C Laxmisha, B S Bibilash, S Rakesh, R Jayasurya, Padhi Rajesh, S Ezhilnilavan, D K Avinash, P S Priyamvada
BACKGROUND: Superficial and deep fungal infections are more frequent in transplant recipients primarily because of the failure of cell-mediated immunity and lesser amount of antigen-presenting Langerhans cells in their epidermis. Here we report seven cases of post-renal transplant subcutaneous phaeohyphomycosis, all of which manifested within 1 year after transplantation and were unresponsive to prolonged courses of itraconazole. This is the first case series, to our knowledge, of phaeohyphomycosis in transplant recipients in India...
October 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28991328/-nasal-phaeohyphomycosis-by-curvularia-spicifera-in-pediatric-patient-with-neutropenia-and-acute-myeloid-leukemia
#6
Constanza Bay, Tamara González, Gonzalo Munoz, Paulette Legarraga, Cecilia Vizcaya, Katia Abarca
There are very few reports of pediatric patients with infections by dematiaceous filamentous fungi. In this publication we report a case of invasive fungal infection of the nasal septum by Curvularia spicifera in a pediatric patient with acute myeloid leukemia. The patient presented with a painful scabby wound in the nasal vestibule. Culture and universal PCR were consistent with Curvularia spicifera. Early management with surgical debridement and bi-associated antifungal therapy achieved complete resolution of the lesions, with no evidence of dissemination and relapses...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28962097/the-first-case-of-cutaneous-phaeohyphomycosis-caused-by-bipolaris-spicifera-in-northern-china-a-case-report
#7
Hongfen Ge, Min Pan, Guanzhi Chen, Xinqiao Liu, Tongxin Shi, Furen Zhang
Phaeohyphomycosis (PHM) is a term used to describe any fungus presenting in tissues with pseudohyphae, hyphae, brown yeast-like cells or a combination of these forms. Sinusitis and skin infections are the most common presentation of subcutaneous PHM caused by the fungus Bipolaris spicifera. However, the majority of cases have so far been encountered in tropical climatic zones. The present study documents a case of subcutaneous PHM caused by infection with Bipolaris spicifera in a 56-year-old Chinese man, who presented with plaque papillomatosis on the left foot...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28923505/subcutaneous-infection-by-graphium-basitruncatum-in-a-heart-transplant-patient
#8
Analía L Fernández, Patricia O Andres, Cecilia H Veciño, Claudia B Nagel, María Teresa Mujica
Graphium basitruncatum, a synanamorph of Pseudoallescheria has been rarely reported in human infections. We report a case of subcutaneous phaeohyphomycosis caused by this fungus in a heart transplant recipient. We also describe the phenotypic, molecular methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) used to achieve isolate identification.
September 15, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28764590/vasculitis-causing-massive-infarction-a-rare-presentation-of-primary-cerebral-phaeohyphomycosis
#9
Rajalakshmi Poyuran, B H Srinivas, Bhawana A Badhe
No abstract text is available yet for this article.
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28761846/phaeohyphomycosis-of-the-face-masquerading-as-basal-cell-carcinoma-in-an-immunocompetent-patient
#10
Sharma Shruti, Avninder Singh, V Ramesh, Fouzia Siraj
Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dermatiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and the central nervous system.Involvement of the face is extremely rare, and very few cases have been reported in India so far. We reporta case of phaeohyphomycosisin a 45-year-old female with 1-year history of a well- defined hypertrophic plaque over the right cheek advancing towards the forehead. The lesion was ulcerated with rolled-up margins; a provisional clinical diagnosis of basal cell carcinoma was given...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28670680/subcutaneous-mycoses-in-peru-a-systematic-review-and-meta-analysis-for-the-burden-of-disease
#11
Max Carlos Ramírez Soto, German Malaga
BACKGROUND: There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. OBJECTIVES: This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. METHODS: We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru...
July 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28631431/phaeohyphomycosis-breast-masquerading-as-fibroadenoma-in-a-young-teenage-girl
#12
Amita Jain Gupta, Meeta Singh, Surekha Yadav, Nita Khurana, Shyam Lata Jain, Rohit Chawla, Sunil Laka, Anurag Mishra
Phaeohyphomycosis is an unusual granulomatous fungal infection, observed in immunocompromised or diabetic patients; however, it is even rarer in immunocompetent patients. Cytological findings of the same have been infrequently reported. The histopathological diagnosis or fungal culture helps in definitive diagnosis to identify the exact fungal species. Hereby, we report a rare case of invasive fungal infection in a breast lump in a young female, presenting as fibroadenoma breast. Fine needle aspiration cytology from the breast lesion showed the presence of septate acute-angled branching fungal hyphae with focal pigmentation, morphologically suggestive of phaeohyphomycosis which was positive with fungal stains...
June 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28627488/diversity-of-veronaea-botryosa-from-different-hosts-and-evaluation-of-laboratory-challenge-models-for-phaeohyphomycosis-in-acipenser-transmontanus
#13
Esteban Soto, Christine Richey, Stephen R Reichley, Brittany Stevens, Kirsten V Kenelty, Janiee Lewis, Barbara Byrne, Nathan P Wiederhold, Thomas B Waltzek, Matthew F Sheley, Alvin C Camus, Matt J Griffin
Veronaea botryosa has been identified as a pathogen of cultured white sturgeon Acipenser transmontanus. In 2015, samples from 19 white sturgeon were received for diagnosis, of which 14 cultured positive for V. botryosa. Intraspecific variability among V. botryosa isolates from different clinically affected hosts and geographic regions was investigated using repetitive extragenic palindromic PCR fingerprinting (rep-PCR). The rep-PCR profiles of 16 V. botryosa isolates from a human, sea turtles, and cultured fish were distinct from those of other phaeoid fungi belonging to the genera Cladophialophora and Exophiala...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28578629/chaetomiaceae-fungi-novel-pathogens-of-equine-neurotropic-phaeohyphomycosis
#14
Quinci Plumlee, Courtney Meason-Smith, Alexandra Dieterly, Gabriel Gomez, Brian F Porter, Aline Rodrigues Hoffmann
Many previously unrecognized fungi are emerging as potential pathogens. One such group is dematiaceous fungi of the Chaetomiaceae family (phylum Ascomycota, class Sordariomycetes). These fungi are rare causes of opportunistic, neurotropic phaeohyphomycosis in humans but are not known to cause similar infections in animals. The aims of this study were to investigate equine hyphal mycotic encephalitis, characterize key histopathologic features, and classify causative organisms with molecular diagnostic techniques...
September 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#15
REVIEW
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28558644/a-case-of-subcutaneous-phaeohyphomycosis-associated-with-leprosy
#16
Márcia M R Teixeira, Claudia B Assunção, Renata R Gomes, Fabiana Rocha-Silva, Sônia M de Figueiredo, Elen R R Teixeira, Adriana S Carneiro, Rogério J M B Júnior, Vânia Vicente, Rachel Basques Caligiorne
Subcutaneous phaeohyphomycosis is a form of infection caused by dematiaceous fungi and frequently reported in the literature. It is considered as an emerging mycosis because it is increasingly reported among immunosuppressive patients. The most commonly cited etiologic agent is Exophiala jeanselmei, followed by Alternaria spp. We present a case of a 48-year-old woman, with a history of lepromatous leprosy, using corticosteroid in immunosuppressive doses due to a type 2 repetitive reaction leprosy outbreak, revealing subcutaneous phaeohyphomycosis lesions...
May 30, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28500778/phaeohyphomycosis-due-to-exophiala-infections-in-solid-organ-transplant-recipients-case-report-and-literature-review
#17
Kate E Oberlin, Anna J Nichols, Rossana Rosa, Adriana Dejman, Adela Mattiazzi, Giselle Guerra, George W Elgart, Lilian M Abbo
This case report and literature review underscores the cutaneous presentations of phaeohyphomycosis in the solid organ transplant population. Increased cognizance with prompt identification is critical. The therapy and clinical outcomes of phaeohyphomycosis, caused by the Exophiala genus, in the solid organ transplant population, is analyzed to examine optimal care. This review highlights the inherent difficulties in providing the appropriate duration of antifungal therapy to avoid relapsing infections in immunosuppressed patients...
August 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28491444/cerebral-pyogranulomatous-encephalitis-caused-by-cladophialophora-bantiana-in-a-15-week-old-domestic-shorthair-kitten
#18
Elise B Russell, Marcus N Gunew, Michelle M Dennis, Catriona L Halliday
CASE SUMMARY: A case of cerebral phaeohyphomycosis caused by Cladophialophora bantiana is described in a 15-week-old domestic shorthair kitten. RELEVANCE AND NOVEL INFORMATION: Cerebral phaeohyphomycosis is a rare condition in cats caused by dematiaceous fungi. This report describes the clinical and histopathological findings in the youngest case documented in a feline, provides a brief review of aetiology, diagnosis, treatment and prognosis of cerebral phaeohyphomycosis and demonstrates the importance of molecular diagnostics in accurate mycotic species identification...
July 2016: JFMS open reports
https://www.readbyqxmd.com/read/28478966/a-rare-case-of-multiple-brain-abscess-and-probably-disseminated-phaeohyphomycosis-due-to-cladophialophora-bantiana-in-an-immunosuppressed-individual-from-india
#19
S Lahiri Mukhopadhyay, A Mahadevan, V H Bahubali, R Dawn Bharath, A R Prabhuraj, S Maji, N Siddaiah
Cladophialophora bantiana, a dematiaceous neurotropic mold causes rare and lethal brain abscess, commonly in immunocompetent hosts. We report a rare and probably a case of disseminated infection with this black mold in an immunosuppressed individual from India. A 55-year-old diabetic male presented with severe headache, blurred-vision, behavioural abnormalities, eye-pain and ear-discharge. He was undergoing treatment for hypertension, prostatomegaly and obstructive pulmonary disease. He was on steroids for the past six years for uveitis...
May 3, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28447292/ecology-of-the-human-opportunistic-black-yeast-exophiala-dermatitidis-indicates-preference-for-human-made-habitats
#20
Monika Novak Babič, Jerneja Zupančič, Nina Gunde-Cimerman, Sybren de Hoog, Polona Zalar
Exophiala dermatitidis is an ascomycetous black yeast from the order Chaetothyriales. Its growth characteristics include the polymorphic life cycle, ability to grow at high and low temperatures, at a wide pH range, survival at high concentrations of NaCl, and survival at high UV and radioactive radiation. Exophiala dermatitidis causes deep or localized phaeohyphomycosis in immuno-compromised people worldwide and is regularly encountered in the lungs of cystic fibrosis patients. Regardless of numerous ecological studies worldwide, little is known about its natural habitat or the possible infection routes...
April 26, 2017: Mycopathologia
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