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https://www.readbyqxmd.com/read/28365816/multiple-brain-abscesses-caused-by-rhinocladiella-mackenziei-in-an-immunocompetent-patient-a-case-report-and-literature-review
#1
Natan Yusupov, Ashirwad Merve, Clare E Warrell, Elizabeth Johnson, Carmel Curtis, George Samandouras
Primary cerebral phaeohyphomycosis due to Rhinocladiella mackenziei is an extremely rare infection carrying more than 80% mortality, with most cases reported from the Middle East region. This darkly pigmented black yeast is highly neurotropic, aggressive and refractory to most antifungal agents. Here we present an immunocompetent elderly male, presenting with multiple brain abscesses, with R. mackenziei confirmed by nuclear ribosomal repeat region sequencing, who was successfully treated by surgical debridement and intravenous voriconazole...
April 1, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28349548/multifocal-but-non-disseminated-phaeohyphomycosis-in-a-healthy-man-via-a-unique-mechanism-ejection-from-mva-into-a-vegetable-field-in-afghanistan-resulting-in-multiple-contaminated-skin-wounds
#2
M Omer Malakzai, Janat Gul Sahak, Ryan Campbell, Mirwais Abobakar, Daniel R Hoogestraat, Dhruba J SenGupta, Andrew Bryan, Jerad M Gardner
A 20 year-old male presented with multiple subcutaneous nodules on the head, neck, chest and oral cavity. FNA and biopsy showed pigmented fungal hyphae diagnostic of multifocal phaeohyphomycosis, found to be Exophiala spinifera by molecular diagnostics. The presentation initially raised concern for disseminated disease and occult immunosuppression. However, the patient appeared to be immunocompetent and otherwise healthy. Upon further inquiry, the patient was in a motor vehicle accident four years before presentation; he was ejected into a vegetable field resulting in multiple open wounds...
March 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28348770/non-traumatic-keratitis-due-to-colletotrichum-truncatum
#3
Reina Llamos, Abdullah M S Al-Hatmi, Gerardo Martínez, Ferry Hagen, Rosario Velar, Alexeide de la Caridad Castillo Pérez, Jacques F Meis, María T Illnait-Zaragozí
INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation. CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28348446/exploring-the-genomic-diversity-of-black-yeasts-and-relatives-chaetothyriales-ascomycota
#4
M M Teixeira, L F Moreno, B J Stielow, A Muszewska, M Hainaut, L Gonzaga, A Abouelleil, J S L Patané, M Priest, R Souza, S Young, K S Ferreira, Q Zeng, M M L da Cunha, A Gladki, B Barker, V A Vicente, E M de Souza, S Almeida, B Henrissat, A T R Vasconcelos, S Deng, H Voglmayr, T A A Moussa, A Gorbushina, M S S Felipe, C A Cuomo, G Sybren de Hoog
The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily melanised fungi and includes numerous etiologic agents of chromoblastomycosis, phaeohyphomycosis and other diseases of vertebrate hosts. Diseases range from mild cutaneous to fatal cerebral or disseminated infections and affect humans and cold-blooded animals globally. In addition, Chaetothyriales comprise species with aquatic, rock-inhabiting, ant-associated, and mycoparasitic life-styles, as well as species that tolerate toxic compounds, suggesting a high degree of versatile extremotolerance...
March 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28295973/cutaneous-phaeohyphomycosis-in-a-hematopoietic-stem-cell-transplant-patient-caused-by-alternaria-rosae-first-case-report
#5
Amy W Liu, Allen C Bateman, Adam Greenbaum, Kanishka Garvin, Jill Clarridge, Jonathan Grim
Alternaria species have been reported as a rare cause of fungal infection in organ and stem cell transplant recipients, but to date no reports have been published of infection in humans caused by Alternaria rosae. Here, we report cutaneous A. rosae infection in a 66-year-old farmer with a history of primary myelofibrosis who had undergone allogeneic unrelated donor hematopoietic stem cell transplantation. Forty-nine days post transplant, he presented with a nodule on the thumb with no findings suggestive of disseminated infection...
March 13, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28295266/cutaneous-phaeohyphomycosis
#6
Mariana P Caviedes, Ana C Torre, Maite Lisa Eliceche, Denise C Valdivia Monteros, Victoria I Volonteri, Ricardo L Galimberti
BACKGROUND: Phaeohyphomycosis is an infrequent infection in human beings. However, in recent years, its prevalence has augmented in immunosuppressed patients (mostly in solid organ transplanted patients). Infection can be mucocutaneous or disseminated. In the former, the fungus inoculation occurs mainly through traumatism. Lesions may be polymorphic and asymptomatic, isolated or multiple, and are usually localized in exposed areas of the limbs and head. Treatment is not standardized. When possible, surgical resection of the lesion is combined with systemic antifungals...
April 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28293689/fungal-melanonychia-ungual-phaeohyphomycosis-caused-by-botryosphaeria-dothidea
#7
Hiromitsu Noguchi, Masataro Hiruma, Tadahiko Matsumoto, Rui Kano, Masaru Tanaka, Takashi Yaguchi, Kazuhiro Sonoda, Hironobu Ihn
is missing (Short communication).
March 15, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28275534/disseminated-phaeohyphomycosis-in-a-dog
#8
Lana S Rothenburg, Timothy A Snider, Allison Wilson, Anthony W Confer, Akhilesh Ramachandran, Rinosh Mani, Theresa Rizzi, Laura Nafe
Phaeohyphomycosis is a rare but emerging disease caused by dematiaceous fungi. Here we describe the case of an immunosuppressed dog with disseminated phaeohyphomycosis secondary to Bipolaris spicifera infection. Regionally extensive infiltration of the paw pads, skin, myocardium, liver, renal interstitium and diaphragm was identified on histopathology. Candida glabrata and Fusarium oxysporum were also cultured from multiple sites post-mortem. The dog was treated with fluconazole, itraconazole, terbinafine and liposomal amphotericin B, but was euthanized due to its poor prognosis after 12 days of therapy...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28217468/subcutaneous-phaeohyphomycosis-in-an-immunocompetent-individual-a-case-report
#9
Sudharani Chintagunta, Geetakiran Arakkal, Sudha V Damarla, Akshay K Vodapalli
Phaeohyphomycosis is a rare mycotic infection caused by various heterogenous groups of phaeoid (dematiaceous) fungi involving the skin and subcutaneous tissue. Common clinical manifestations are subcutaneous abscesses or cystic swellings. Here, we report a case of subcutaneous phaeohyphomycosis presenting as multiple asymptomatic cystic swellings over the hands and feet without any predisposing factors. Histopathology showed granulomatous inflammation and special stain with Grocott's methanamine silver stain revealed broad pigmented hyphae...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28209838/genome-sequence-of-type-strain-fonsecaea-multimorphosa-cbs-980-96-t-a-causal-agent-of-feline-cerebral-phaeohyphomycosis
#10
Aniele C Ribas Leao, Vinicius Almir Weiss, Vania Aparecida Vicente, Flavia Costa, Amanda Bombassaro, Roberto Tadeu Raittz, Maria Berenice R Steffens, Fabio Oliveira Pedrosa, Renata R Gomes, Valter Baura, Helisson Faoro, Michelle Zibetti Tadra Sfeir, Eduardo Balsanelli, Leandro F Moreno, M Javad Najafzadeh, Sybren de Hoog, Emanuel Maltempi Souza
A draft genome sequence of type strain Fonsecaea multimorphosa CBS 980.96(T) was obtained. This species was first isolated from a cat with cerebral phaeohyphomycosis in Queensland, Australia.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28194139/1-10-phenanthroline-5-6-dione-based-compounds-are-effective-in-disturbing-crucial-physiological-events-of-phialophora-verrucosa
#11
Marcela Queiroz Granato, Diego de Souza Gonçalves, Sergio Henrique Seabra, Malachy McCann, Michael Devereux, André Luis Souza Dos Santos, Lucimar Ferreira Kneipp
Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2](+)) and [Cu(phendione)3](ClO4)2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28187150/phylogenomic-analyses-reveal-the-diversity-of-laccase-coding-genes-in-fonsecaea-genomes
#12
Leandro Ferreira Moreno, Peiying Feng, Vinicius Almir Weiss, Vania Aparecida Vicente, J Benjamin Stielow, Sybren de Hoog
The genus Fonsecaea comprises black yeast-like fungi of clinical relevance, including etiologic agents of chromoblastomycosis and cerebral phaeohyphomycosis. Presence of melanin and assimilation of monoaromatic hydrocarbons and alkylbenzenes have been proposed as virulence factors. Multicopper oxidase (MCO) is a family of enzymes including laccases, ferroxidases and ascorbate oxidases which are able to catalyze the oxidation of various aromatic organic compounds with the reduction of molecular oxygen to water...
2017: PloS One
https://www.readbyqxmd.com/read/28101893/the-genus-anthopsis-and-its-phylogenetic-position-in-chaetothyriales
#13
Tarek A A Moussa, Bert H G Gerrits van den Ende, Hassan S Al Zahrani, Naif M S Kadasa, Sybren G de Hoog, Somayeh Dolatabadi
The genus Anthopsis was introduced for a black fungus with peculiar, inverted phialides and triangular conidia. The genus accommodates, in addition to the type species Anthopsis deltoidea, which once was reported as a cause of human phaeohyphomycosis, two further taxa: A. catenata and A. microspora. Current taxonomy is mainly based on microscopic structures of phialides. To assess the phylogenetic position of the genus, sequences of the internal transcribed spacer region and partial LSU rDNA were obtained for Anthopsis spp...
April 2017: Mycoses
https://www.readbyqxmd.com/read/28100598/molecular-and-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-based-characterization-of-clinically-significant-melanized-fungi-in-india
#14
Ashutosh Singh, Pradeep Kumar Singh, Anil Kumar, Jagdish Chander, Geetika Khanna, Pradip Roy, Jacques F Meis, Anuradha Chowdhary
Melanized or black fungi are a heterogeneous group of fungi causing cutaneous to systemic diseases with high mortality. These fungi are rarely reported as agents of human infections, primarily due to difficulties in their classical identification. In this study, we examined, using molecular methods and matrix-assisted laser desorption ioniazation-time of flight mass spectrometry (MALDI-TOF MS), the diversity of melanized fungi (MF) isolated from patients in 19 medical centers in India. Overall, during a 4-year period, 718 (5...
April 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28080920/phaeohyphomycosis-associated-with-ossification-of-the-skull-and-cervical-vertebrae-in-a-swell-shark-cephaloscyllium-ventriosum
#15
Claire D Erlacher-Reid, Hendrik H Nollens, Todd L Schmitt, Judy St Leger, Sarena Sunico
A female, captive bred, juvenile swell shark ( Cephaloscyllium ventriosum ) was observed swimming in tight circles and rolling. Radiographs and computed tomography of this individual revealed extensive cartilage mineralization of the skull and cranial cervical vertebrae compared with diagnostic images of clinically healthy conspecifics. Gross necropsy and histopathologic examination revealed ossification and fibrosis of the cartilaginous matrix of the skull and cervical vertebrae with deep invasion by a pigmented hyphal fungus...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28062320/melanized-fungal-infections-in-kidney-transplant-recipients-contributions-to-optimize-clinical-management
#16
D Wagner de Castro Lima Santos, L Fernando Aranha Camargo, S Santos Gonçalves, M Marufuji Ogawa, J Tomimori, M M Simões E Silva Enokihara, J Osmar Medina Pestana, Arnaldo Lopes Colombo
OBJECTIVES: This is a retrospective and observational study addressing clinical and therapeutic aspects of melanized fungal infections in kidney transplant recipients. METHODS: We retrospectively reviewed medical records of all patients admitted between January 1996 and December 2013 in a single institution who developed infections by melanized fungi. RESULTS: We reported on 56 patients aged between 30 and 74 years with phaeohyphomycosis or chromoblastomycosis (0...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28057425/oral-phaeohyphomycosis-in-a-patient-with-squamocellular-carcinoma-of-the-lip-second-case-report
#17
Suanni Lemos de Andrade, André Ferraz Goiana Leal, Armando Marsden Lacerda Filho, Danielle Patrícia Cerqueira Macêdo, Maria do Carmo Carvalho de Abreu E Lima, Rejane Pereira Neves
This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed...
April 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28053851/verruconis-gallopava-cardiac-and-endovascular-infection-with-dissemination-after-renal-transplantation-case-report-and-lessons-learned
#18
Zoe Jennings, Kathy Kable, Catriona L Halliday, Brian J Nankivell, Jen Kok, Germaine Wong, Sharon C-A Chen
Verruconis gallopava is an uncommon cause of phaeohyphomycosis. We describe an unusual case of disseminated V. gallopava infection in a renal transplant recipient involving the endocardium but without endocarditis, associated with fungaemia and infection in the skin, oral cavity, brain and lung. The isolate was first detected from blood cultures which is rare. Surgical resection of cardiac fungal mass was not possible. The patient died despite resolution of fungaemia and combination antifungal therapy.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28025758/cutaneous-exophiala-oligosperma-infection-in-a-patient-with-bullous-pemphigoid-with-a-review-of-the-literature
#19
Chau Yee Ng, Sybren de Hoog, Hua-En Li, Yung-Yi Lee, Chun-Bing Chen, Pei-Lun Sun
Phaeohyphomycosis is an infection caused by a heterogeneous group of melanized fungi. Human infections due to members of genus Exophiala are rare but may occur at any part of the body. We herein report a case of an 85-year-old male with a history of bullous pemphigoid who presented with a chronic, non-healing wound on his right dorsal hand for a month. Direct microscopy of a pus sample from the base of the ulcer revealed strands of pigmented, moniliform hyphae. The isolate was identified as E. oligosperma based on morphological characters and sequencing of the rDNA internal transcribed spacers (ITS) and partial beta-tubulin gene...
December 26, 2016: Mycopathologia
https://www.readbyqxmd.com/read/28007938/an-updated-comprehensive-systematic-review-of-cladophialophora-bantiana-and-analysis-of-epidemiology-clinical-characteristics-and-outcome-of-cerebral-cases
#20
A Serda Kantarcioglu, Josep Guarro, Sybren De Hoog, Hulya Apaydin, Nuri Kiraz
Cladophialophora bantiana is a phaeoid fungus that only rarely has been isolated from sources other than the human brain. It has a particular tropism for the central nervous system (CNS). We have integrated and updated large-scale data related to several aspects of C. Bantiana and reviewed all the available reports on its cerebral infections, focusing on their geographical distribution, infection routes, immune status of infected individuals, type and location of infections, clinical manifestations and treatment and outcome, briefly looking over the spectrum of other disease entities associated with C...
December 22, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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