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https://www.readbyqxmd.com/read/28396061/-chromomycosis-acquired-in-a-non-tropical-area-a-case-report
#1
M S Ouédraogo, M-D Vignon-Pennamen, M Battistella, A Levy, M Feuilhade de Chauvin, A Petit
BACKGROUND: Chromomycosis, or chromoblastomycosis, is caused by cutaneous inoculation of dematiaceous fungi of telluric or plant origin. It is generally seen in tropical or subtropical zones. Treatment of the condition is known to be complex. Herein we report a case of chromomycosis contracted in a temperate region of Eastern Europe/Central Asia that was effectively treated with oral itraconazole and terbinafine in combination with cryotherapy. PATIENTS AND METHODS: A 44-year-old immunocompetent male subject consulted for a lesion on the buttocks that he had sustained 16 years earlier, and which, although never previously treated, had only become troublesome within the last few months...
April 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28355277/modulation-of-the-immune-response-by-fonsecaea-pedrosoi-morphotypes-in-the-course-of-experimental-chromoblastomycosis-and-their-role-on-inflammatory-response-chronicity
#2
Isaque Medeiros Siqueira, Raffael Júnio Araújo de Castro, Luiza Chaves de Miranda Leonhardt, Márcio Sousa Jerônimo, Aluízio Carlos Soares, Tainá Raiol, Christiane Nishibe, Nalvo Almeida, Aldo Henrique Tavares, Christian Hoffmann, Anamelia Lorenzetti Bocca
A common theme across multiple fungal pathogens is their ability to impair the establishment of a protective immune response. Although early inflammation is beneficial in containing the infection, an uncontrolled inflammatory response is detrimental and may eventually oppose disease eradication. Chromoblastomycosis (CBM), a cutaneous and subcutaneous mycosis, caused by dematiaceous fungi, is capable of inducing a chronic inflammatory response. Muriform cells, the parasitic form of Fonsecaea pedrosoi, are highly prevalent in infected tissues, especially in long-standing lesions...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28348446/exploring-the-genomic-diversity-of-black-yeasts-and-relatives-chaetothyriales-ascomycota
#3
M M Teixeira, L F Moreno, B J Stielow, A Muszewska, M Hainaut, L Gonzaga, A Abouelleil, J S L Patané, M Priest, R Souza, S Young, K S Ferreira, Q Zeng, M M L da Cunha, A Gladki, B Barker, V A Vicente, E M de Souza, S Almeida, B Henrissat, A T R Vasconcelos, S Deng, H Voglmayr, T A A Moussa, A Gorbushina, M S S Felipe, C A Cuomo, G Sybren de Hoog
The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily melanised fungi and includes numerous etiologic agents of chromoblastomycosis, phaeohyphomycosis and other diseases of vertebrate hosts. Diseases range from mild cutaneous to fatal cerebral or disseminated infections and affect humans and cold-blooded animals globally. In addition, Chaetothyriales comprise species with aquatic, rock-inhabiting, ant-associated, and mycoparasitic life-styles, as well as species that tolerate toxic compounds, suggesting a high degree of versatile extremotolerance...
March 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28194139/1-10-phenanthroline-5-6-dione-based-compounds-are-effective-in-disturbing-crucial-physiological-events-of-phialophora-verrucosa
#4
Marcela Queiroz Granato, Diego de Souza Gonçalves, Sergio Henrique Seabra, Malachy McCann, Michael Devereux, André Luis Souza Dos Santos, Lucimar Ferreira Kneipp
Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2](+)) and [Cu(phendione)3](ClO4)2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28187150/phylogenomic-analyses-reveal-the-diversity-of-laccase-coding-genes-in-fonsecaea-genomes
#5
Leandro Ferreira Moreno, Peiying Feng, Vinicius Almir Weiss, Vania Aparecida Vicente, J Benjamin Stielow, Sybren de Hoog
The genus Fonsecaea comprises black yeast-like fungi of clinical relevance, including etiologic agents of chromoblastomycosis and cerebral phaeohyphomycosis. Presence of melanin and assimilation of monoaromatic hydrocarbons and alkylbenzenes have been proposed as virulence factors. Multicopper oxidase (MCO) is a family of enzymes including laccases, ferroxidases and ascorbate oxidases which are able to catalyze the oxidation of various aromatic organic compounds with the reduction of molecular oxygen to water...
2017: PloS One
https://www.readbyqxmd.com/read/28179902/severe-chromoblastomycosis-like-cutaneous-infection-caused-by-chrysosporium-keratinophilum
#6
Juhaer Mijiti, Bo Pan, Sybren de Hoog, Yoshikazu Horie, Tetsuhiro Matsuzawa, Yilixiati Yilifan, Yong Liu, Parida Abliz, Weihua Pan, Danqi Deng, Yun Guo, Peiliang Zhang, Wanqing Liao, Shuwen Deng
Chrysosporium species are saprophytic filamentous fungi commonly found in the soil, dung, and animal fur. Subcutaneous infection caused by this organism is rare in humans. We report a case of subcutaneous fungal infection caused by Chrysosporium keratinophilum in a 38-year-old woman. The patient presented with severe chromoblastomycosis-like lesions on the left side of the jaw and neck for 6 years. She also got tinea corporis on her trunk since she was 10 years old. Chrysosporium keratinophilum was isolated from the tissue on the neck and scales on the trunk, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28122015/correction-molecular-epidemiology-of-agents-of-human-chromoblastomycosis-in-brazil-with-the-description-of-two-novel-species
#7
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0005102.].
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28062320/melanized-fungal-infections-in-kidney-transplant-recipients-contributions-to-optimize-clinical-management
#8
D Wagner de Castro Lima Santos, L Fernando Aranha Camargo, S Santos Gonçalves, M Marufuji Ogawa, J Tomimori, M M Simões E Silva Enokihara, J Osmar Medina Pestana, Arnaldo Lopes Colombo
OBJECTIVES: This is a retrospective and observational study addressing clinical and therapeutic aspects of melanized fungal infections in kidney transplant recipients. METHODS: We retrospectively reviewed medical records of all patients admitted between January 1996 and December 2013 in a single institution who developed infections by melanized fungi. RESULTS: We reported on 56 patients aged between 30 and 74 years with phaeohyphomycosis or chromoblastomycosis (0...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28053146/molecular-identification-of-chromoblastomycosis-clinical-isolates-in-guangdong
#9
Cindy Fransisca, Ya He, Zhiwen Chen, Hongfang Liu, Liyan Xi
Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue. The most common etiologic agent encountered in Southern China is from the genus Fonsecaea. Fonsecaea species are often misidentified due to indistinct morphology features; furthermore, recent taxonomy revision was done on the fungi genus. Herein, a comprehensive evaluation with molecular sequencing data based on internal transcribed spacer (ITS) ribosomal DNA regions as molecular targets were implemented to 37 clinical isolates from chromoblastomycosis patients...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27922892/galectin-3-expression-in-benign-and-malignant-skin-diseases-with-epidermal-hyperplasia
#10
Ze-Xin Jiang, Guo-Zhen Tan, Zhen-Rui Shi, Yu-Ping Zhang, Yan-Fang Han, Liangchun Wang
Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6...
November 7, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27904208/verrucous-onychomycosis-caused-by-curvularia-in-a-patient-with-congenital-pterygium
#11
Mary Vineetha, Seena Palakkal, K Sobhanakumari, M I Celine, V Letha
A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. After excision biopsy patient was started on oral itraconazole. This case is reported due to rarity of verrucous cutaneous lesions caused by curvularia in immunocompetent individuals...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27904058/two-cases-of-chromomycosis-identified-by-molecular-phylogenetic-analysis
#12
Takayo Mitomo, Yukiko Ushigome, Tomoo Fukuda, Yoko Kano, Tetsuo Shiohara
Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. While there are many kinds of dematiaceous fungi, the major etiologic agent is Fonsecaea pedrosoi, which to date has accounted for 90% of chromoblastomycosis cases. The genus Fonsecaea has recently been assessed via rRNA ITS sequence analysis, and species have been classified into F...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27893750/molecular-epidemiology-of-agents-of-human-chromoblastomycosis-in-brazil-with-the-description-of-two-novel-species
#13
Renata R Gomes, Vania A Vicente, Conceição M P S de Azevedo, Claudio G Salgado, Moises B da Silva, Flávio Queiroz-Telles, Sirlei G Marques, Daniel W C L Santos, Tania S de Andrade, Elizabeth H Takagi, Katia S Cruz, Gheniffer Fornari, Rosane C Hahn, Maria L Scroferneker, Rachel B Caligine, Mauricio Ramirez-Castrillon, Daniella P de Araújo, Daiane Heidrich, Arnaldo L Colombo, G S de Hoog
The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin genes. Strains studied were limited to three clusters divided over the single family Herpotrichiellaceae known to comprise agents of the disease. A Fonsecaea cluster contained the most important agents, among which F...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27856522/chromoblastomycosis
#14
REVIEW
Flavio Queiroz-Telles, Sybren de Hoog, Daniel Wagner C L Santos, Claudio Guedes Salgado, Vania Aparecida Vicente, Alexandro Bonifaz, Emmanuel Roilides, Liyan Xi, Conceição de Maria Pedrozo E Silva Azevedo, Moises Batista da Silva, Zoe Dorothea Pana, Arnaldo Lopes Colombo, Thomas J Walsh
Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue...
January 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/27843190/chromoblastomycosis-caused-by-cladophialophora-carrionii-in-a-skin-graft-recipient
#15
Partha Roy, S Prasanna, Dudhat Vaibhav Laxmikant, C N Chaudhari
No abstract text is available yet for this article.
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27828652/response-of-chromoblastomycosis-to-voriconazole
#16
Alexandre Moretti de Lima, Gabriely Lessa Sacht, Lauren Zogbi Pereira de Paula, Gabriela Kimie Aseka, Hermann Soares Goetz, Maicon Felippe Gheller, Pedro de Freitas Silva Torraca
Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to voriconazole.
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27726899/first-case-of-chromoblastomycosis-due-to-phoma-insulana
#17
Francisca Hernández-Hernández, Jaime Vargas-Arzola, Oliver Pedro Ríos-Cruz, Erika Córdova-Martínez, Patricia Manzano-Gayosso, Aristeo Segura-Salvador
Chromoblastomycosis is a chronic infection, caused by pigmented fungi affecting skin and subcutaneous tissues characterized by verrucous nodules or plaques. Fonsecaea pedrosoi and Cladophialophora carrionii are the prevalent agents in the endemic areas. Phoma is an uncommon agent of human infection and involved mainly with phaeohyphomycosis cases. The case of a patient with a history of laceration in foot followed by verrucous aspect and scaly lesions, which had evolved for 27 years is presented. On physical examination disease was clinically compatible with chromoblastomycosis and the microscopic examination of scales showed fumagoid cells...
October 7, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27628109/phaeohyphomycosis-caused-by-rhytidhysteron-rufulum-and-review-of-literature
#18
REVIEW
Jagdish Chander, Nidhi Singla, Reetu Kundu, Uma Handa, Anuradha Chowdhary
Phaeohyphomycosis is caused by a heterogeneous group of mycelial dematiaceous (phaeoid) fungi, which produce melanin pigment. This condition is often confused with chromoblastomycosis. Rhytidhysteron is a dematiaceous fungus, which has been recently found to be causing human infections. Till date only three cases of infection with Rhytidhysteron rufulum have been reported in the literature. All three cases have been from North India. Hereby, we present another two cases where Rhytidhysteron was isolated. Both the patients belonged to Chandigarh (India) and presented with subcutaneous lesions...
April 2017: Mycopathologia
https://www.readbyqxmd.com/read/27626154/fonsecaea-pedrosoi-as-a-rare-cause-of-acute-conjunctival-ulceration
#19
Fatih Mehmet Adibelli, Nilgun Karabicak, Ali Akal, Tugba Goncu, Omer Faruk Yilmaz, Mehmet Bayraktar
Conjunctival ulceration accompanied with secretion and pain was observed in a 30-year-old male, 3 days after a perforating corneal trauma. Cultures of conjunctival ulcer samples grew Fonsecaea pedrosoi, a major causative agent of chromoblastomycosis that is typically transmitted during trauma. The conjunctival ulcer was successfully treated with amphotericin B, itraconazole, and fluconazole. This case report summarizes the diagnosis and treatment of a conjunctival ulcer due to F. pedrosoi, which is a rare complication of contaminated ocular trauma...
July 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27524747/the-effectiveness-of-a-multifocal-training-to-improve-the-treatment-of-chromoblastomycosis-in-rural-madagascar
#20
Aaron Santmyire
Madagascar has the highest number of cases of chromoblastomycosis in the world, but the areas of highest incidence have limited affordable access and knowledge of first line medications to treat this long-term fungal infection of the skin and subcutaneous tissue. The impact of a multifocal training targeting medical doctors who live in the area of the country with the highest prevalence of this disease has not been clearly reported. The purpose of this project was to determine the effect of a multifocal training on chromoblastomycosis for Malagasy medical doctors in the SAVA (Sambava, Andapa, Vohemar, and Antalaha) province of Madagascar (in the country's northeast) about diagnosis, staging, patient education poster, and treatment options of chromoblastomycosis versus common treatment practices to increase participant's knowledge and utilization of current treatment recommendations for chromoblastomycosis...
2016: Journal of Health Care for the Poor and Underserved
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