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https://www.readbyqxmd.com/read/27922892/galectin-3-expression-in-benign-and-malignant-skin-diseases-with-epidermal-hyperplasia
#1
Ze-Xin Jiang, Guo-Zhen Tan, Zhen-Rui Shi, Yu-Ping Zhang, Yan-Fang Han, Liangchun Wang
Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6...
November 7, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27904208/verrucous-onychomycosis-caused-by-curvularia-in-a-patient-with-congenital-pterygium
#2
Mary Vineetha, Seena Palakkal, K Sobhanakumari, M I Celine, V Letha
A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. After excision biopsy patient was started on oral itraconazole. This case is reported due to rarity of verrucous cutaneous lesions caused by curvularia in immunocompetent individuals...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27904058/two-cases-of-chromomycosis-identified-by-molecular-phylogenetic-analysis
#3
Takayo Mitomo, Yukiko Ushigome, Tomoo Fukuda, Yoko Kano, Tetsuo Shiohara
Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. While there are many kinds of dematiaceous fungi, the major etiologic agent is Fonsecaea pedrosoi, which to date has accounted for 90% of chromoblastomycosis cases. The genus Fonsecaea has recently been assessed via rRNA ITS sequence analysis, and species have been classified into F...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27893750/molecular-epidemiology-of-agents-of-human-chromoblastomycosis-in-brazil-with-the-description-of-two-novel-species
#4
Renata R Gomes, Vania A Vicente, Conceição M P S de Azevedo, Claudio G Salgado, Moises B da Silva, Flávio Queiroz-Telles, Sirlei G Marques, Daniel W C L Santos, Tania S de Andrade, Elizabeth H Takagi, Katia S Cruz, Gheniffer Fornari, Rosane C Hahn, Maria L Scroferneker, Rachel B Caligine, Mauricio Ramirez-Castrillon, Daniella P de Araújo, Daiane Heidrich, Arnaldo L Colombo, G S de Hoog
The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin genes. Strains studied were limited to three clusters divided over the single family Herpotrichiellaceae known to comprise agents of the disease. A Fonsecaea cluster contained the most important agents, among which F...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27856522/chromoblastomycosis
#5
REVIEW
Flavio Queiroz-Telles, Sybren de Hoog, Daniel Wagner C L Santos, Claudio Guedes Salgado, Vania Aparecida Vicente, Alexandro Bonifaz, Emmanuel Roilides, Liyan Xi, Conceição de Maria Pedrozo E Silva Azevedo, Moises Batista da Silva, Zoe Dorothea Pana, Arnaldo Lopes Colombo, Thomas J Walsh
Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue...
January 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/27843190/chromoblastomycosis-caused-by-cladophialophora-carrionii-in-a-skin-graft-recipient
#6
Partha Roy, S Prasanna, Dudhat Vaibhav Laxmikant, C N Chaudhari
No abstract text is available yet for this article.
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27828652/response-of-chromoblastomycosis-to-voriconazole
#7
Alexandre Moretti de Lima, Gabriely Lessa Sacht, Lauren Zogbi Pereira de Paula, Gabriela Kimie Aseka, Hermann Soares Goetz, Maicon Felippe Gheller, Pedro de Freitas Silva Torraca
Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to voriconazole.
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27726899/first-case-of-chromoblastomycosis-due-to-phoma-insulana
#8
Francisca Hernández-Hernández, Jaime Vargas-Arzola, Oliver Pedro Ríos-Cruz, Erika Córdova-Martínez, Patricia Manzano-Gayosso, Aristeo Segura-Salvador
Chromoblastomycosis is a chronic infection, caused by pigmented fungi affecting skin and subcutaneous tissues characterized by verrucous nodules or plaques. Fonsecaea pedrosoi and Cladophialophora carrionii are the prevalent agents in the endemic areas. Phoma is an uncommon agent of human infection and involved mainly with phaeohyphomycosis cases. The case of a patient with a history of laceration in foot followed by verrucous aspect and scaly lesions, which had evolved for 27 years is presented. On physical examination disease was clinically compatible with chromoblastomycosis and the microscopic examination of scales showed fumagoid cells...
October 7, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27628109/phaeohyphomycosis-caused-by-rhytidhysteron-rufulum-and-review-of-literature
#9
Jagdish Chander, Nidhi Singla, Reetu Kundu, Uma Handa, Anuradha Chowdhary
Phaeohyphomycosis is caused by a heterogeneous group of mycelial dematiaceous (phaeoid) fungi, which produce melanin pigment. This condition is often confused with chromoblastomycosis. Rhytidhysteron is a dematiaceous fungus, which has been recently found to be causing human infections. Till date only three cases of infection with Rhytidhysteron rufulum have been reported in the literature. All three cases have been from North India. Hereby, we present another two cases where Rhytidhysteron was isolated. Both the patients belonged to Chandigarh (India) and presented with subcutaneous lesions...
September 15, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27626154/fonsecaea-pedrosoi-as-a-rare-cause-of-acute-conjunctival-ulceration
#10
Fatih Mehmet Adibelli, Nilgun Karabicak, Ali Akal, Tugba Goncu, Omer Faruk Yilmaz, Mehmet Bayraktar
Conjunctival ulceration accompanied with secretion and pain was observed in a 30-year-old male, 3 days after a perforating corneal trauma. Cultures of conjunctival ulcer samples grew Fonsecaea pedrosoi, a major causative agent of chromoblastomycosis that is typically transmitted during trauma. The conjunctival ulcer was successfully treated with amphotericin B, itraconazole, and fluconazole. This case report summarizes the diagnosis and treatment of a conjunctival ulcer due to F. pedrosoi, which is a rare complication of contaminated ocular trauma...
July 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27524747/the-effectiveness-of-a-multifocal-training-to-improve-the-treatment-of-chromoblastomycosis-in-rural-madagascar
#11
Aaron Santmyire
Madagascar has the highest number of cases of chromoblastomycosis in the world, but the areas of highest incidence have limited affordable access and knowledge of first line medications to treat this long-term fungal infection of the skin and subcutaneous tissue. The impact of a multifocal training targeting medical doctors who live in the area of the country with the highest prevalence of this disease has not been clearly reported. The purpose of this project was to determine the effect of a multifocal training on chromoblastomycosis for Malagasy medical doctors in the SAVA (Sambava, Andapa, Vohemar, and Antalaha) province of Madagascar (in the country's northeast) about diagnosis, staging, patient education poster, and treatment options of chromoblastomycosis versus common treatment practices to increase participant's knowledge and utilization of current treatment recommendations for chromoblastomycosis...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27491988/draft-genome-sequence-of-fonsecaea-nubica-strain-cbs-269-64-causative-agent-of-human-chromoblastomycosis
#12
Flávia F Costa, Sybren de Hoog, Roberto T Raittz, Vinicius A Weiss, Aniele C R Leão, Amanda Bombassaro, Jiufeng Sun, Leandro F Moreno, Emanuel M Souza, Fabio O Pedrosa, Maria Berenice R Steffens, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, M Javad Najafzadeh, Renata R Gomes, Maria S Felipe, Marcus Teixeira, Germana D Santos, Liyan Xi, Mauro Antônio Alves de Castro, Vânia A Vicente
On the basis of multilocus phylogenetic data, Fonsecaea nubica was described in 2010 as a molecular sibling of F. monophora, an established agent of the human skin disease chomoblastomycosis in tropical zones. Genome analysis of these pathogens is mandatory to identify genes involved in the interaction with host and virulence.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27469960/draft-genome-sequence-of-fonsecaea-monophora-strain-cbs-269-37-an-agent-of-human-chromoblastomycosis
#13
Amanda Bombassaro, Sybren de Hoog, Vinicius A Weiss, Emanuel M Souza, Aniele C R Leão, Flávia F Costa, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, Leandro F Moreno, Roberto T Raittz, Maria Berenice R Steffens, Fabio O Pedrosa, Jiufeng Sun, Liyan Xi, Anamélia L Bocca, Maria S Felipe, Marcus Teixeira, Germana D Santos, Flávio Q Telles Filho, Conceição M P S Azevedo, Renata R Gomes, Vânia A Vicente
The black yeast Fonsecaea monophora is one of the main etiologic agents of chromoblastomycosis in humans. Its pathogenicity profile is more invasive than that of related Fonsecaea species, causing brain infection in addition to (sub)cutaneous infections.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27456474/subcutaneous-phaeohyphomycosis-caused-by-exophiala-spinifera-in-a-european-patient-with-lymphoma-a-rare-occurrence-case-report-and-literature-review
#14
G Bohelay, S Robert, C Bouges-Michel, M Gerin, A Levy, O Fain, F Caux
Exophiala spinifera is a dematiaceous fungus responsible for rare skin infections presenting as phaeohyphomycosis or chromoblastomycosis which has been primarily reported in tropical and subtropical areas (Asia, South and North America). We report the first case of E. spinifera phaeohyphomycosis in a European patient. The phaeohyphomycosis was limited to the skin, involving the finger of an immunocompromised patient presenting with a large B-cell lymphoma treated by R-mini-CHOP regimen. Remission was initially achieved by surgical excision; however, a local subcutaneous relapse required treatment with itraconazole...
November 2016: Mycoses
https://www.readbyqxmd.com/read/27419178/ten-year-experience-of-cutaneous-and-or-subcutaneous-infections-due-to-coelomycetes-in-france
#15
Sarah Guégan, Dea Garcia-Hermoso, Karine Sitbon, Sarah Ahmed, Philippe Moguelet, Françoise Dromer, Olivier Lortholary
Background.  Coelomycetes are rarely but increasingly reported in association with human infections involving mostly skin and subcutaneous tissues, both in immunocompetent and immunocompromised patients. Coelomycetes constitute a heterogeneous group of filamentous fungi with distinct morphological characteristics in culture, namely an ability to produce asexual spores within fruit bodies. Methods.  We included all cases of proven primary cutaneous and/or subcutaneous infections due to coelomycetes received for identification at the French National Reference Center for Invasive Mycoses and Antifungals between 2005 and 2014...
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27402133/immune-response-in-human-chromoblastomycosis-and-eumycetoma-focusing-on-human-interleukin-17a-interferon-gamma-tumour-necrosis-factor-alpha-interleukin-1-beta-and-human-beta-defensin-2
#16
Charussri Leeyaphan, Carren Hau, Shintaro Takeoka, Yayoi Tada, Sumanas Bunyaratavej, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Angkana Chaiprasert, Yuko Sasajima, Koichi Makimura, Shinichi Watanabe
Knowledge regarding host immune response to chromoblastomycosis and eumycetoma is limited, particularly concerning cytokines and antimicrobial peptides production. This was a retrospective study of 12 paraffin-embedded tissue samples from patients diagnosed with chromoblastomycosis or eumycetoma from histological findings and tissue culture. DNA extraction and polymerase chain reaction (PCR) from tissues were done to evaluate human interleukin-17A (IL-17A), interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and human beta-defensin-2 (HBD-2) expressions...
July 12, 2016: Mycoses
https://www.readbyqxmd.com/read/27374381/cutaneous-involvement-in-the-deep-mycoses-a-literature-review-part-i-subcutaneous-mycoses
#17
J E Carrasco-Zuber, C Navarrete-Dechent, A Bonifaz, F Fich, V Vial-Letelier, D Berroeta-Mauriziano
The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. In the first part of this review, we describe the main subcutaneous mycoses: sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis, and lacaziosis. Early recognition and treatment is important, as these infections are frequently associated with high morbidity...
June 30, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27330937/chromoblastomycosis-due-to-fonsecaea-monophora-misdiagnosed-as-sporotrichosis-and-cutaneous-tuberculosis-in-a-pulmonary-tuberculosis-patient
#18
Dongmei Shi, Wei Zhang, Guixia Lu, G Sybren de Hoog, Guanzhao Liang, Huan Mei, Hailin Zheng, Yongnian Shen, Weida Liu
Chromoblastomycosis is caused by dematiaceous fungi. It develops after inoculation of the organism into the skin. We report a case of chromoblastomycosis in a pulmonary tuberculosis patient without known history of trauma. The lesions were initially diagnosed as sporotrichosis and skin tuberculosis. Histopathology of scales and skin biopsy specimen revealed sclerotic bodies, the hallmark of chromoblastomycosis. The causative organism was identified as Fonsecaea monophora by rDNA ITS sequencing. The lesions recovered markedly after two month treatment with oral terbinafine 250 mg daily according to drug sensitive test in vitro in combination with local thermotherapy...
March 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27330936/corrigendum-to-first-case-of-chromoblastomycosis-from-bangladesh-med-mycol-case-rep-10-2015-1-3
#19
Sophie Brun, Coralie Zumelzu, Mai Ba Hoanganh, Annie Levy, Dea Garcia-Hermoso, Liliane Laroche, Arezki Izri
[This corrects the article DOI: 10.1016/j.mmcr.2015.08.001.].
March 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27330038/a-case-of-chromoblastomycosis-by-fonsecaea-nubica-indicating-a-possible-insect-route-of-transmission
#20
Yingdan Chen, Songchao Yin, Meirong Li, Rongzhang Chen, Ling Wei, Han Ma, Shuwen Deng, Gert Sybren de Hoog, Wei Lai, Chun Lu, Peiying Feng
A first auricular case of chromoblastomycosis due to Fonsecaea nubica is reported in a 42-year-old Chinese male. He presented a slightly verrucous, erythematous plaque on his right auricle which had gradually extended over a 10-year period, and the patient reported a history of dog flea sting before onset of the lesions. Diagnosis was based on histopathological and mycological examination of clinical samples, which revealed muriform cells. Identification of the aetiological agent was assessed by morphological characteristics and confirmed at species level by sequencing of the rDNA internal transcribed spacer (ITS)...
October 2016: Mycoses
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