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Francisca Hernández-Hernández, Jaime Vargas-Arzola, Oliver Pedro Ríos-Cruz, Erika Córdova-Martínez, Patricia Manzano-Gayosso, Aristeo Segura-Salvador
Chromoblastomycosis is a chronic infection, caused by pigmented fungi affecting skin and subcutaneous tissues characterized by verrucous nodules or plaques. Fonsecaea pedrosoi and Cladophialophora carrionii are the prevalent agents in the endemic areas. Phoma is an uncommon agent of human infection and involved mainly with phaeohyphomycosis cases. The case of a patient with a history of laceration in foot followed by verrucous aspect and scaly lesions, which had evolved for 27 years is presented. On physical examination disease was clinically compatible with chromoblastomycosis and the microscopic examination of scales showed fumagoid cells...
October 7, 2016: Enfermedades Infecciosas y Microbiología Clínica
Jagdish Chander, Nidhi Singla, Reetu Kundu, Uma Handa, Anuradha Chowdhary
Phaeohyphomycosis is caused by a heterogeneous group of mycelial dematiaceous (phaeoid) fungi, which produce melanin pigment. This condition is often confused with chromoblastomycosis. Rhytidhysteron is a dematiaceous fungus, which has been recently found to be causing human infections. Till date only three cases of infection with Rhytidhysteron rufulum have been reported in the literature. All three cases have been from North India. Hereby, we present another two cases where Rhytidhysteron was isolated. Both the patients belonged to Chandigarh (India) and presented with subcutaneous lesions...
September 15, 2016: Mycopathologia
Fatih Mehmet Adibelli, Nilgun Karabicak, Ali Akal, Tugba Goncu, Omer Faruk Yilmaz, Mehmet Bayraktar
Conjunctival ulceration accompanied with secretion and pain was observed in a 30-year-old male, 3 days after a perforating corneal trauma. Cultures of conjunctival ulcer samples grew Fonsecaea pedrosoi, a major causative agent of chromoblastomycosis that is typically transmitted during trauma. The conjunctival ulcer was successfully treated with amphotericin B, itraconazole, and fluconazole. This case report summarizes the diagnosis and treatment of a conjunctival ulcer due to F. pedrosoi, which is a rare complication of contaminated ocular trauma...
July 2016: Arquivos Brasileiros de Oftalmologia
Aaron Santmyire
Madagascar has the highest number of cases of chromoblastomycosis in the world, but the areas of highest incidence have limited affordable access and knowledge of first line medications to treat this long-term fungal infection of the skin and subcutaneous tissue. The impact of a multifocal training targeting medical doctors who live in the area of the country with the highest prevalence of this disease has not been clearly reported. The purpose of this project was to determine the effect of a multifocal training on chromoblastomycosis for Malagasy medical doctors in the SAVA (Sambava, Andapa, Vohemar, and Antalaha) province of Madagascar (in the country's northeast) about diagnosis, staging, patient education poster, and treatment options of chromoblastomycosis versus common treatment practices to increase participant's knowledge and utilization of current treatment recommendations for chromoblastomycosis...
2016: Journal of Health Care for the Poor and Underserved
Flávia F Costa, Sybren de Hoog, Roberto T Raittz, Vinicius A Weiss, Aniele C R Leão, Amanda Bombassaro, Jiufeng Sun, Leandro F Moreno, Emanuel M Souza, Fabio O Pedrosa, Maria Berenice R Steffens, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, M Javad Najafzadeh, Renata R Gomes, Maria S Felipe, Marcus Teixeira, Germana D Santos, Liyan Xi, Mauro Antônio Alves de Castro, Vânia A Vicente
On the basis of multilocus phylogenetic data, Fonsecaea nubica was described in 2010 as a molecular sibling of F. monophora, an established agent of the human skin disease chomoblastomycosis in tropical zones. Genome analysis of these pathogens is mandatory to identify genes involved in the interaction with host and virulence.
2016: Genome Announcements
Amanda Bombassaro, Sybren de Hoog, Vinicius A Weiss, Emanuel M Souza, Aniele C R Leão, Flávia F Costa, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, Leandro F Moreno, Roberto T Raittz, Maria Berenice R Steffens, Fabio O Pedrosa, Jiufeng Sun, Liyan Xi, Anamélia L Bocca, Maria S Felipe, Marcus Teixeira, Germana D Santos, Flávio Q Telles Filho, Conceição M P S Azevedo, Renata R Gomes, Vânia A Vicente
The black yeast Fonsecaea monophora is one of the main etiologic agents of chromoblastomycosis in humans. Its pathogenicity profile is more invasive than that of related Fonsecaea species, causing brain infection in addition to (sub)cutaneous infections.
2016: Genome Announcements
G Bohelay, S Robert, C Bouges-Michel, M Gerin, A Levy, O Fain, F Caux
Exophiala spinifera is a dematiaceous fungus responsible for rare skin infections presenting as phaeohyphomycosis or chromoblastomycosis which has been primarily reported in tropical and subtropical areas (Asia, South and North America). We report the first case of E. spinifera phaeohyphomycosis in a European patient. The phaeohyphomycosis was limited to the skin, involving the finger of an immunocompromised patient presenting with a large B-cell lymphoma treated by R-mini-CHOP regimen. Remission was initially achieved by surgical excision; however, a local subcutaneous relapse required treatment with itraconazole...
November 2016: Mycoses
Sarah Guégan, Dea Garcia-Hermoso, Karine Sitbon, Sarah Ahmed, Philippe Moguelet, Françoise Dromer, Olivier Lortholary
Background.  Coelomycetes are rarely but increasingly reported in association with human infections involving mostly skin and subcutaneous tissues, both in immunocompetent and immunocompromised patients. Coelomycetes constitute a heterogeneous group of filamentous fungi with distinct morphological characteristics in culture, namely an ability to produce asexual spores within fruit bodies. Methods.  We included all cases of proven primary cutaneous and/or subcutaneous infections due to coelomycetes received for identification at the French National Reference Center for Invasive Mycoses and Antifungals between 2005 and 2014...
April 2016: Open Forum Infectious Diseases
Charussri Leeyaphan, Carren Hau, Shintaro Takeoka, Yayoi Tada, Sumanas Bunyaratavej, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Angkana Chaiprasert, Yuko Sasajima, Koichi Makimura, Shinichi Watanabe
Knowledge regarding host immune response to chromoblastomycosis and eumycetoma is limited, particularly concerning cytokines and antimicrobial peptides production. This was a retrospective study of 12 paraffin-embedded tissue samples from patients diagnosed with chromoblastomycosis or eumycetoma from histological findings and tissue culture. DNA extraction and polymerase chain reaction (PCR) from tissues were done to evaluate human interleukin-17A (IL-17A), interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and human beta-defensin-2 (HBD-2) expressions...
July 12, 2016: Mycoses
J E Carrasco-Zuber, C Navarrete-Dechent, A Bonifaz, F Fich, V Vial-Letelier, D Berroeta-Mauriziano
The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. In the first part of this review, we describe the main subcutaneous mycoses: sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis, and lacaziosis. Early recognition and treatment is important, as these infections are frequently associated with high morbidity...
June 30, 2016: Actas Dermo-sifiliográficas
Dongmei Shi, Wei Zhang, Guixia Lu, G Sybren de Hoog, Guanzhao Liang, Huan Mei, Hailin Zheng, Yongnian Shen, Weida Liu
Chromoblastomycosis is caused by dematiaceous fungi. It develops after inoculation of the organism into the skin. We report a case of chromoblastomycosis in a pulmonary tuberculosis patient without known history of trauma. The lesions were initially diagnosed as sporotrichosis and skin tuberculosis. Histopathology of scales and skin biopsy specimen revealed sclerotic bodies, the hallmark of chromoblastomycosis. The causative organism was identified as Fonsecaea monophora by rDNA ITS sequencing. The lesions recovered markedly after two month treatment with oral terbinafine 250 mg daily according to drug sensitive test in vitro in combination with local thermotherapy...
March 2016: Medical Mycology Case Reports
Sophie Brun, Coralie Zumelzu, Mai Ba Hoanganh, Annie Levy, Dea Garcia-Hermoso, Liliane Laroche, Arezki Izri
[This corrects the article DOI: 10.1016/j.mmcr.2015.08.001.].
March 2016: Medical Mycology Case Reports
Yingdan Chen, Songchao Yin, Meirong Li, Rongzhang Chen, Ling Wei, Han Ma, Shuwen Deng, Gert Sybren de Hoog, Wei Lai, Chun Lu, Peiying Feng
A first auricular case of chromoblastomycosis due to Fonsecaea nubica is reported in a 42-year-old Chinese male. He presented a slightly verrucous, erythematous plaque on his right auricle which had gradually extended over a 10-year period, and the patient reported a history of dog flea sting before onset of the lesions. Diagnosis was based on histopathological and mycological examination of clinical samples, which revealed muriform cells. Identification of the aetiological agent was assessed by morphological characteristics and confirmed at species level by sequencing of the rDNA internal transcribed spacer (ITS)...
October 2016: Mycoses
Sahana M Srinivas, Vykuntaraju K Gowda, S Mahantesh, Rajeshwari Mannapur, Sanjay K Shivappa
Chromoblastomycosis is a chronic granulomatous infection of the skin and subcutaneous tissue caused by specific group of dematiaceous fungi. The infection results from traumatic injury and is seen more commonly on feet and lower legs. It is rarely seen in children and metastatic spread to other systems is exceptionally rare. We report a 12-year-old immunocompetent male child diagnosed with chromoblastomycosis on the lower leg, who in a span of few months developed osteomyelitis and left hemiparesis. Fungal culture showed growth of Exophiala spinifera...
May 2016: Indian Journal of Dermatology
Kalyan Khan, Krishnendu Mondal, Rupsha Dutta, Palash Kumar Mandal, Rupali Mandal, Mamata Mallick Sinha Guha
No abstract text is available yet for this article.
May 3, 2016: American Journal of Dermatopathology
Gopikrishnan Anjaneyan, Soumya Jagadeesan, Jacob Thomas
No abstract text is available yet for this article.
March 2016: Indian Dermatology Online Journal
Marilia M Ogawa, Marcella P Peternelli, Milvia M S S Enokihara, Angela S Nishikaku, Sarah Santos Gonçalves, Jane Tomimori
Chromoblastomycosis and phaeohyphomycosis are melanized fungal infections, which affect skin and subcutaneous tissues in immunocompetent and immunosuppressed patients, as solid-organ transplant recipients, respectively. In this present study, we report six cases of melanized fungal infection in kidney transplant recipients. In five cases, culture of tissue specimens identified two cases of Exophiala spp. and three cases of Fonsecaea spp. Molecular identification was performed in three cases based on sequencing of rDNA (ITS region) that revealed the following agents: Exophiala xenobiotica, Exophiala bergeri and Fonsecaea monophora...
June 2016: Mycopathologia
Hirak Jyoti Raj, Banashree Majumdar, Atul Jain, Prasanta Kumar Maiti, Gobinda Chatterjee
INTRODUCTION: Verrucous plaques mimicking chromoblastomycosis are frequently seen in dermatology outpatient departments (OPD). However, no scientific evaluation has been carried out till date from eastern India. So this present endeavour is aimed at a thorough study of those cases to readdress the challenges in diagnosis and management in chromoblastomycosis from this part of the country. AIM: The study is to observe the incidence of proved chromoblastomycosis cases from clinically mimicking conditions and to note therapeutic prospects by use of different antifungal agents...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
John Verrinder Veasey, Beatriz de Abreu Ribeiro Machado, Rute Facchini Lellis, Laura Hitomi Muramatu, Clarisse Zaitz
Chromoblastomycosis is a chronic subcutaneous fungal infection caused by traumatic implantation of dematiaceous fungi in the skin. The clinical presentation is usually a verrucous plaque lesion and the diagnosis is confirmed by the visualization of muriform bodies at direct examination or at the histologic study. This report describes a rare case of tumoral chromoblastomycosis confirmed by histologic study and whose agent was identified by culture and micromorphology.
November 2015: Anais Brasileiros de Dermatologia
Alison Spiker, Tammie Ferringer
No abstract text is available yet for this article.
October 2015: Cutis; Cutaneous Medicine for the Practitioner
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