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gastric cancer and early detection

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https://www.readbyqxmd.com/read/28819389/discovery-of-non-invasive-glycan-biomarkers-for-detection-and-surveillance-of-gastric-cancer
#1
Ruihuan Qin, Junjie Zhao, Wenjun Qin, Zejian Zhang, Ran Zhao, Jing Han, Yupeng Yang, Lixiao Li, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu
Purpose: Gastric cancer (GC), one of the world's top five most common cancers, is the third leading cause of cancer related death. It is urgent to identify non-invasive biomarkers for GC. The objective of our study was to find out non-invasive biomarkers for early detection and surveillance of GC based on glycomic analysis. Method: Ethyl esterification derivatization combined with MALDI-TOF MS analysis was employed for the comprehensive serum glycomic analysis in order to investigate glycan markers that would indicate the onset and progression of gastric cancer...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28803237/atf3-dependent-regulation-of-egr1-in-vitro-and-in-vivo
#2
Ilona Schoen, Sabine Koitzsch
BACKGROUND/AIMS: Activating transcription factor 3 (ATF3) and early growth response protein 1 (EGR1) are reported to interact, but their use as prognostic factors in cancer is discussed controversially. METHODS: We measured ATF3 and EGR1 gene expression changes in human mini-organ cultures (MOCs) of healthy nasal epithelia, UM-SCC-22B, and FADUDD cells after acid reflux exposure. Next, ATF3 and EGR1 gene expression was analysed in tumour tissues and related to the median expression of autologous reference tissue samples...
August 12, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28799258/helicobacter-pylori-infection-and-serum-level-of-pepsinogen-are-associated-with-the-risk-of-metachronous-gastric-neoplasm-after-endoscopic-resection
#3
Y Kwon, S Jeon, S Nam, I Shin
BACKGROUND: Patients who have undergone endoscopic resection of early gastric cancers (EGCs) are at risk for metachronous gastric neoplasm. AIM: To determine whether serum level of pepsinogen (PG), a marker of gastric atrophy, can determine which patients who have undergone endoscopic submucosal dissection for EGC are at risk for metachronous gastric neoplasm. We also investigated the effects of Helicobacter pylori eradication on metachronous gastric neoplasm incidence...
August 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28798286/the-characteristics-and-prognosis-of-diffuse-type-early-gastric-cancer-diagnosed-during-health-check-ups
#4
Ji Young Lee, Eun Jeong Gong, Eun Ju Chung, Hye Won Park, Suh Eun Bae, Eun Hee Kim, Jaeil Kim, Yoon Suh Do, Tae Hyup Kim, Hye-Sook Chang, Ho June Song, Jaewon Choe, Hwoon-Yong Jung
Background/Aims: Because of the poor prognosis of diffuse-type gastric cancer, early detection is important. We investigated the clinical characteristics and prognosis of diffuse-type early gastric cancer (EGC) diagnosed in subjects during health check-ups. Methods: Among 121,111 subjects who underwent gastroscopy during a routine health check-up, we identified 282 patients with 286 EGC lesions and reviewed their clinical and tumor-specific parameters. Results: Patients with diffuse-type EGC were younger, and 48...
August 14, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28796840/yes-research-matters
#5
Mari L Shinohara
My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with Helicobacter pylori, a bacterial species found in the digestive tract. In Japan, where he lives, a majority of gastric cancer patients (more than 99%) have been infected with H...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28768706/the-prevalence-of-cancer-associated-autoantibodies-in-patients-with-gastric-cancer-and-progressive-grades-of-premalignant-lesions
#6
Irēna Meistere, Simone Werner, Pawel Zayakin, Karīna Siliņa, Undīne Rulle, Angelina Pismennaja, Daiga Šantare, Ilze Kikuste, Sergejs Isajevs, Marcis Leja, Limas Kupčinskas, Juozas Kupčinskas, Laimas Jonaitis, Chun-Ying Wu, Hermann Brenner, Aija Linē, Zane Kalniņa
BACKGROUND: Serum autoantibodies against tumor-associated antigens (TAA) are detectable in early stage gastric cancer patients; however, the time point during cancerogenesis when they appear in circulation is still obscure. METHODS: In this study, we developed a recombinant antigen microarray and analyzed the prevalence of autoantibodies against 102 TAAs in 829 gastric cancer patients and 929 healthy controls from Caucasian and Asian populations, as well as 100 patients with chronic atrophic gastritis and 775 individuals staged according to different grades of intestinal metaplasia...
August 2, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28753702/probe-based-endomicroscopy-for-in-vivo-detection-of-gastric-intestinal-metaplasia-and-neoplasia-a-multicenter-randomized-controlled-trial
#7
Xiu-Li Zuo, Zhen Li, Chang-Qing Li, You-You Zheng, Li-Dong Xu, Jie Chen, Rong Lin, Jun Song, Chao-Hui Yu, Min Yue, Qi Zhou, Zhi-Yan Liu, Yan-Qing Li
Background and study aims Owing to the indistinctive endoscopic appearance of gastric intestinal metaplasia (GIM), gastric intraepithelial neoplasia (GIN), and early gastric cancer (EGC), a significant number of such lesions may be missed during surveillance endoscopy. The aim of this clinical trial was to assess the value of combined computed virtual chromoendoscopy (flexible spectral imaging color enhancement [FICE]) and probe-based confocal laser endomicroscopy (pCLE) for in vivo detection of GIM, GIN, and EGC...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28741059/postoperative-follow-up-programs-improve-survival-in-curatively-resected-gastric-and-junctional-cancer-patients-a-propensity-score-matched-analysis
#8
Leila Sisic, Moritz J Strowitzki, Susanne Blank, Henrik Nienhueser, Sara Dorr, Georg Martin Haag, Dirk Jäger, Katja Ott, Markus W Büchler, Alexis Ulrich, Thomas Schmidt
BACKGROUND: To date there is no evidence that more intensive follow-up after surgery for esophagogastric adenocarcinoma translates into improved survival. This study aimed to evaluate the impact of standardized surveillance by a specialized center after resection on survival. METHODS: Data of 587 patients were analyzed who underwent curative surgery for esophagogastric adenocarcinoma in our institution. Based on their postoperative surveillance, patients were assigned to either standardized follow-up (SFU) by the National Center for Tumor Diseases (SFU group) or individual follow-up by other physicians (non-SFU group)...
July 24, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28739707/early-gastric-cancer-exfoliating-into-gastric-lavage-gl1-egc-shows-a-more-aggressive-behavior-and-poorer-survival-compared-to-the-non-exfoliative-counterpart-gl0-egc
#9
Edoardo Virgilio, Enrico Giarnieri, Maria Rosaria Giovagnoli, Monica Montagnini, Antonella Proietti, Rosaria D'Urso, Paolo Mercantini, Genoveffa Balducci, Marco Cavallini
BACKGROUND/AIM: Early gastric cancer (EGC) is usually associated with excellent prognosis. Some cases, however, entail a poorer survival. Our aim was to assess if EGC exfoliating into gastric lavage (GL) has a more aggressive behavior than the non-exfoliative counterpart. PATIENTS AND METHODS: Between April 2012 and April 2017, 96 gastric cancer patients were prospectively submitted to preoperative GL to detect the presence (GL1) or absence (GL0) of exfoliated malignant cells...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28731617/in-vivo-diagnosis-of-early-stage-gastric-cancer-found-after-helicobacter-pylori-eradication-using-probe-based-confocal-laser-endomicroscopy
#10
Noriyuki Horiguchi, Tomomitsu Tahara, T Hyuga Yamada, Dai Yoshida, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda, Naoki Ohmiya
BACKGROUND AND AIM: Early-stage gastric cancer (EGC) found after Helicobacter pylori (Hp) eradication often displays non-tumorous regenerative epithelium and/or maturated tumorous epithelium overlying the cancerous tissue, which may confuse endoscopic and histologic diagnosis. Probe-based confocal laser endomicroscopy (pCLE) enables in vivo real-time optical biopsy. We compared the diagnostic yields for these EGC cases using conventional white light endoscopy (WL), magnifying endoscopy with narrow-band imaging (ME-NBI), pCLE, and endoscopic biopsy; we also compared the accuracy of the horizontal extent diagnosis between ME-NBI and pCLE...
July 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28725964/toward-early-detection-of-helicobacter-pylori-associated-gastric-cancer
#11
Rachel Walker, Jan Poleszczuk, Jaime Mejia, Jae K Lee, Jose M Pimiento, Mokenge Malafa, Anna R Giuliano, Heiko Enderling, Domenico Coppola
BACKGROUND: Gastric cancer is typically diagnosed at a late stage, leading to poor prognoses. Helicobacter pylori is responsible for 70% of gastric cancers globally, and patients with this bacterial infection often present with early stages of the carcinogenic pathway such as inflammation or gastritis. Although many patients continue to progress to advanced-stage disease after antibacterial treatment, there are no follow-up screening protocols for patients with a history of H. pylori...
July 19, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28724210/dandelion-root-extract-suppressed-gastric-cancer-cells-proliferation-and-migration-through-targeting-lncrna-ccat1
#12
Huanhuan Zhu, Hangyong Zhao, Linjie Zhang, Jianmin Xu, Chunhua Zhu, Hui Zhao, Guoqiang Lv
Gastric cancer (GC) is one of the most common tumors worldwide. Standard treatment after early detection involves surgical excision (recurrence is possible), and metastatic gastric cancer is refractory to immuno-, radio-, and most harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically and effectively suppresses proliferation and migration in human gastric cells without inducing toxicity in noncancerous cells...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28723792/concomitant-stromal-tumor-and-early-cancer-of-the-stomach-what-should-be-done
#13
COMPARATIVE STUDY
Yan Xu, Liangfang Shen, Zhaoxia Lu, Xiaowei Liu, Wei Wu, Deyun Feng, Jaladanki N Rao, Lan Xiao, Miao Ouyang
Concomitant gastric stromal tumor (GST) and gastric cancer (GC) is uncommon; even more uncommon is a concomitant GST and early stage GC (EGC). Tumor resection by endoscopic submucosal dissection (ESD) for concomitant GST and EGC has not been reported. We sought to define the clinical importance of detection of concomitant GST and EGC during the first esophagogastroduodenoscopy (EGD), and compare the clinical outcomes of ESD versus radical surgery for the treatment of concomitant GST and EGC. Our investigation was a retrospective cohort study...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722091/-analysis-of-lymph-node-metastasis-pattern-in-gastric-cancer-patients-at-stage-pn1
#14
Bin Ke, Ning Liu, Rupeng Zhang, Xiaofan Guo, Bin Li, Xuejun Wang, Han Liang
OBJECTIVE: To investigate the lymph node metastasis pattern in pN1 stage gastric cancer patients and to analyze its risk factors. METHODS: Clinicopathological data of 219 patients who underwent radical gastrectomy and were confirmed as pN1 stage gastric cancer between January 2013 and March 2016 were reviewed. All the patients underwent D2 or extended D2(D2+) lymphadenectomy. The overall metastatic rate was calculated. The risk factors associated with lymph node metastasis were analyzed...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#15
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28700998/a-decrease-of-histone-deacetylase-6-expression-caused-by-helicobacter-pylori-infection-is-associated-with-oncogenic-transformation-in-gastric-cancer
#16
Qing He, Guoqiang Li, Xin Wang, Shubin Wang, Jiang Hu, Lang Yang, Yuqi He, Yuanming Pan, Dedong Yu, Yun Wu
BACKGROUND: Histone deacetylase 6 (HDAC6) plays a role in the progression of many tumors. However, the relationship between the level of HDAC6 expression and gastric tumorigenesis is still unclear. Here, we illustrate the potential correlation between Helicobacter pylori (HP) infection and the variation of HDAC6 expression in different gastric lesions, as well as the clinical significance of HDAC6 expression in gastric cancer (GC) patients. MATERIALS AND METHODS: Between 2011 and 2016, 364 patients with different types of gastric lesions were enrolled in Baotou City Central Hospital...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28694666/clinical-importance-of-colonoscopy-in-patients-with-gastric-neoplasm-undergoing-endoscopic-submucosal-dissection
#17
Chieko Tsuchida, Naoto Yoshitake, Hitoshi Kino, Yoshihito Kaneko, Masakazu Nakano, Kohei Tsuchida, Keiichi Tominaga, Takako Sasai, Hironori Masuyama, Hidetsugu Yamagishi, Yasuo Imai, Hideyuki Hiraishi
AIM: To evaluate the usefulness of total colonoscopy (TCS) for patients undergoing gastric endoscopic submucosal dissection (ESD) and to assess risk factors for colorectal neoplasms. METHODS: Of the 263 patients who underwent ESD at our department between May 2010 and December 2013, 172 patients undergoing TCS during a one-year period before and after ESD were targeted. After excluding patients with a history of surgery or endoscopic therapy for colorectal neoplasms, 158 patients were analyzed...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28685935/gastric-gland-mucin-specific-o-glycan-expression-decreases-with-tumor-progression-from-precursor-lesions-to-pancreatic-cancer
#18
Ayumi Ohya, Kazuhiro Yamanoi, Hisashi Shimojo, Chifumi Fujii, Jun Nakayama
Pancreatic cancer is lethal, as it is often detected late. Thus novel biomarkers of precursor lesions are needed to devise timely therapies. Pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) are major precursors of pancreatic cancer. In normal gastric mucosa, gastric gland mucin-specific O-glycans are unique in having α1,4-linked N-acetylglucosamine (αGlcNAc) residues attached to MUC6. Recently we reported that αGlcNAc functions as a tumor suppressor for differentiated-type gastric adenocarcinoma (Karasawa et al...
July 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/28680720/multiple-primary-malignancies-in-patients-with-multiple-early-gastric-cancer
#19
Dae Hoon Kim, Su Mi Kim, Min Gew Choi, Tae Sung Sohn, Jae Moon Bae, Sung Kim
PURPOSE: This study aimed to investigate the correlation between multiple early gastric cancer (MEGC) and multiple primary malignancies during the follow-up of patients with gastrectomy. MATERIALS AND METHODS: The number of primary tumors detected in other organs after gastrectomy for early gastric cancer (EGC) has been increasing because of improved survival and surveillance programs. A total of 3,129 patients underwent radical gastrectomy for treatment of EGC at Samsung Medical Center from January 2000 to December 2005...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28675538/the-frequency-and-risk-factors-of-colorectal-adenoma-in-patients-with-early-gastric-cancer
#20
Hyun Hee Chung, Kyeong Ok Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
BACKGROUND/AIMS: The authors aimed to determine the clinical value of colonoscopy by evaluating the frequency of colorectal neoplasm detection in patients with early gastric cancer (EGC) as compared with healthy controls and analyzed the risk factors of advanced colorectal neoplasm in patients with EGC. METHODS: The medical records of 201 patients diagnosed as EGC and age and gender matched healthycontrols were retrospectively reviewed. Frequencies and clinical features of colorectal polyps of patients and controls were compared...
July 4, 2017: Internal Medicine Journal
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