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gastric cancer and early detection

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https://www.readbyqxmd.com/read/28548950/enolase-1-stimulates-glycolysis-to-promote-chemoresistance-in-gastric-cancer
#1
Xiaoling Qian, Wenxia Xu, Jinye Xu, Qiqi Shi, Jiaqiu Li, Yu Weng, Zhinong Jiang, Lifeng Feng, Xian Wang, Jianwei Zhou, Hongchuan Jin
Chemotherapy is the major choice for the cancer treatment of early and advanced stages. However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of chemotherapy. It is critical to develop novel approaches to detect and overcome drug resistance. In this study, we demonstrated that accelerated glycolysis played a pivotal role in both intrinsic and acquired cisplatin-resistance of gastric cancer cells. The metabolic reprogramming of cisplatin-resistant cells was characterized by increased glycolysis dependence...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28542582/clinical-implications-of-pre-existing-adenoma-in-endoscopically-resected-early-gastric-cancers
#2
Ji Min Choi, Sang Gyun Kim, Jung Kim, Seung Jun Han, Jae Yong Park, Sooyeon Oh, Jong Pil Im, Joo Sung Kim, Woo Ho Kim, Hyun Chae Jung
BACKGROUND: Although gastric adenoma is widely accepted as a precursor of gastric cancer, pre-existing adenoma is not always detected in gastric cancer patients. OBJECTIVE: To investigate the clinical characteristics of early gastric cancer (EGC) arising from adenoma, compared with those of EGC without pre-existing adenoma. METHODS: Patients who underwent endoscopic resection for EGC at a single tertiary hospital were divided into two groups based on the presence (ex-adenoma group) or absence (de novo group) of pre-existing adenoma on pathologic specimens...
2017: PloS One
https://www.readbyqxmd.com/read/28540486/the-expression-of-mcm7-is-a-useful-biomarker-in-the-early-diagnostic-of-gastric-cancer
#3
Jing-Yan Yang, Dong Li, Yuan Zhang, Bing-Xin Guan, Ping Gao, Xing-Chen Zhou, Cheng-Jun Zhou
The aim of this study was to investigate the expression of minichromosome maintenance complex component 7 (MCM7) in gastric mucosal lesions, further to find its potential effect as a biomarker to distinguish intraepithelial neoplasia from gastric mucosal lesions. MCM7 and Ki67 were detected in 93 cases of gastric mucosal lesions by immunohistochemistry. MCM7 and Ki67 expression in GT were lowest compared with other groups (P<0.001), meanwhile there were significant differences compared with Group IM and other groups in MCM7 and Ki67 expression (P<0...
May 25, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28536487/current-status-and-challenges-in-sentinel-node-navigation-surgery-for-early-gastric-cancer
#4
Bang Wool Eom, Young-Il Kim, Hong Man Yoon, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Soo Jin Kim, Ji Yoon Rho, Seok Ki Kim, Myeong-Cherl Kook, Young-Woo Kim, Keun Won Ryu
Although a number of feasibility studies for sentinel node (SN) concepts in gastric cancer have been conducted since 2000, there remains a debate regarding detailed detection techniques and oncological safety. Two important multicenter phase II clinical trials were performed in Japan that used different methods and reached different conclusions; one confirmed acceptable results with a false-negative rate of 7%, and the other showed an unacceptably high false-negative rate of 46.4%. The Sentinel Node Oriented Tailored Approach (SENORITA) trial is a multicenter randomized controlled phase III trial being performed in Korea...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28534362/the-expression-of-claudin-4-in-gastric-cancer-tissue-a-single-center-experience
#5
Demetrios Moris, Dimitrios Schizas, Adamantios Michalinos, Prodromos Kanavidis, Nikolaos Dimitrokallis, Andreas Alexandrou, Evangelos Misiakos, Theodoros Liakakos
PURPOSE: Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors diagnosed at advanced stage. The need for identification of prognostic and early detection biomarkers is thus compulsory. Claudins are biomarkers that are currently evaluated in the literature in the frame of epithelial-mesenchymal transition. The purpose of this investigation was to study the expression of claudin-4 in the various histological subtypes of GC and to evaluate its prognostic value...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28534359/e-cadherin-in-gastric-carcinomas-relations-with-histological-parameters-and-its-prognostic-value
#6
Dimitrios Schizas, Demetrios Moris, Adamantios Michalinos, Prodromos Kanavidis, Dimitrios Oikonomou, Alexandros Papalampros, Anastasios Machairas, Theodoros Liakakos
PURPOSE: Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors being diagnosed at advanced stage. The need for identification of prognostic and early detection biomarkers is thus compulsory. E-cadherin is one of the emerging biomarkers that is currently evaluated in the literature in the frame of epithelial-mesenchymal transition (EMT). Our aim was to study the expression of E-cadherin in the various histological subtypes of GC and to evaluate its prognostic value...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28529617/combined-detection-of-plasma-zic1-hoxd10-and-runx3-methylation-is-a-promising-strategy-for-early-detection-of-gastric-cancer-and-precancerous-lesions
#7
Zhenghua Lin, Mengzhao Luo, Xueqing Chen, Xingkang He, Yun Qian, Sanchuan Lai, Jianmin Si, Shujie Chen
We try to explore the value of aberrant DNA methylation of several cancer-related genes in plasma as non-invasive biomarkers for gastric cancer (GC) and precancerous lesions. By using methylation-specific polymerase chain reaction assay we determined the methylation status of three selected genes ZIC1, HOXD10 and RUNX3 in blood samples from patients with GC and precancerous lesions. We discovered that the methylation rate of ZIC1, HOXD10 and RUNX3 increased significantly in the progression of gastric carcinogenesis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28522256/sporadic-early-onset-diffuse-gastric-cancers-have-high-frequency-of-somatic-cdh1-alterations-but-low-frequency-of-somatic-rhoa-mutations-compared-with-late-onset-cancers
#8
Soo Young Cho, Jun Won Park, Yang Liu, Young Soo Park, Ju Hee Kim, Hanna Yang, Hyejin Um, Woo Ri Ko, Byung Il Lee, Sun Young Kwon, Seung Wan Ryu, Chae Hwa Kwon, Do Youn Park, Jae-Hyuk Lee, Sang Il Lee, Kyu Sang Song, Hoon Hur, Sang-Uk Han, Heekyung Chang, Su-Jin Kim, Byung-Sik Kim, Jeong-Hwan Yook, Moon-Won Yoo, Beom-Su Kim, In-Seob Lee, Myeong-Cherl Kook, Nina Thiessen, An He, Chip Stewart, Andrew Dunford, Jaegil Kim, Juliann Shih, Gordon Saksena, Andrew D Cherniack, Steven Schumacher, Amaro-Taylor Weiner, Mara Rosenberg, Gad Getz, Eun Gyeong Yang, Min Hee Ryu, Adam J Bass, Hark Kyun Kim
BACKGROUND & AIMS: Early-onset gastric cancer, which develops in younger patients than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic diffuse gastric cancers (DGCs) from younger patients. METHODS: We conducted whole exome and RNA sequence analyses of 80 resected DGC samples from patients 45 years old or younger in Korea...
May 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28515354/clinical-application-and-outcomes-of-sentinel-node-navigation-surgery-in-patients-with-early-gastric-cancer
#9
Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Keishi Okubo, Takashi Kijima, Daisuke Matsushita, Masahiko Amatatsu, Takahiko Hagihara, Naoto Haraguchi, Yuko Mataki, Katsuhiko Ehi, Sumiya Ishigami, Shoji Natsugoe
Sentinel node navigation surgery (SNNS) has been recognized as a minimally invasive tool for individualized lymphadenectomy in patients with early gastric cancer (EGC). The aim of this study was to compare clinicopathological factors, adverse events, and clinical outcomes between sentinel node mapping (SNM) and SN dissection (SND) groups and assess the clinical utility of SNNS in patients with EGC. The clinical data of 157 patients with EGC, diagnosed as clinical T1N0M0 with tumors ≤ 40 mm, undergoing SNNS between March 2004 and April 2016 were retrospectively reviewed...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514766/current-status-of-lymph-node-micrometastasis-in-gastric-cancer
#10
REVIEW
Yang Zhou, Guo-Jing Zhang, Ji Wang, Kai-Yuan Zheng, Weihua Fu
Lymph node metastasis is one of the most important prognostic factors in patients with gastric cancer. An inadequate number of dissected lymph nodes is an independent risk factor affecting recurrence, even in patients who are node negative. Oddly, certain early-stage patients still experience recurrence or metastasis within a short time, even if they have undergone standard radical mastectomy. Many researchers have attributed these adverse events to lymph node micrometastasis (LNM), which is defined as a microscopic deposit of malignant cells of less than 2 mm in diameter...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493146/laparoscopic-proximal-gastrectomy-with-oblique-jejunogastrostomy
#11
Kimitaka Tanaka, Yuma Ebihara, Yo Kurashima, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Soichi Murakami, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Proximal early gastric cancer is a good indication for totally laparoscopic proximal gastrectomy (TLPG) with double-tract reconstruction (DTR). However, when most of the dietary intake passes through the escape route of the jejunum, the functional benefits of proximal gastrectomy might be similar to those after total gastrectomy. Our DTR procedure was improved for easy passage through the remnant stomach. The purposes of this study were to present a novel technique for intracorporeal DTR using linear staplers after TLPG and to investigate surgical outcomes...
May 10, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28489839/-deregulation-of-micrornas-in-gastric-cancer-up-regulation-by-mir-21-and-mir-106
#12
Luis Alejandro Arias Sosa, Andrés Felipe Cuspoca Orduz, Bibiana Matilde Bernal Gómez
Gastric cancer (GC) exhibits significant rates of mortality worldwide, a situation that is even more disturbing in Colombia, because it has had historically high rate for that disease; At regional context we have found that Boyacá has the second place of gastric cancer mortality rate in the country, with displeasing numbers. Early detection is critical to the survival of people, so in this article, major based on world literature search, we show that the microRNA could be a useful tool for the diagnosis, prognosis and can be designed as important therapeutic target...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28482669/evaluation-of-mir-22-and-mir-20a-as-diagnostic-biomarkers-for-gastric-cancer
#13
Zahra Jafarzadeh-Samani, Sareh Sohrabi, Khadije Shirmohammadi, Hosein Effatpanah, Reza Yadegarazari, Massoud Saidijam
BACKGROUND: Gastric cancer (GC) is the fourth most common cancers and the second reason for cancer-related death around the world, particularly in East Asian countries. Diagnosing GC in its early stages is followed by more successful treatment. Unfortunately, there is no accurate method for GC diagnosis in its early stages. Recently, miRNAs have been investigated in the most cancer researches which have demonstrated that they have been dysregulated in many cancers. METHODS: This case-control study aims to investigate the expression rate of miR-22 and miR-20a in 32 cancerous tissues as well as 32 healthy adjacent tissues...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28470943/serum-level-of-c-reactive-protein-on-postoperative-day-3-is-a-predictive-indicator-of-postoperative-pancreatic-fistula-after-laparoscopic-gastrectomy-for-gastric-cancer
#14
Tomoyuki Matsunaga, Hiroaki Saito, Yuki Murakami, Hirohiko Kuroda, Yoji Fukumoto, Tomohiro Osaki
INTRODUCTION: Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. It is vitally important to detect signs of POPF in the early postoperative period and perform adequate management to avoid patient death. The aim of this study was to investigate the predictive indicators of POPF after laparoscopic gastrectomy for gastric cancer. METHODS: The current study included 197 patients who were pathologically diagnosed with adenocarcinoma and underwent laparoscopic gastrectomy between January 2010 and December 2014 in our hospital...
May 4, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28464590/-analysis-of-incidence-and-mortality-for-upper-digestive-tract-cancers-and-results-of-early-detection-and-treatment-program-in-feicheng-shandong-province
#15
L Yi, T Zhao, Y Y Li, W Q Chen, D L Zhao
Objective: To investigate the trend of esophageal and stomach cancer incidence and mortality in Feicheng during 2000 to 2013, and to evaluate the effects of the national project of screening for upper digestive tract cancers from 2006 to 2015 in Feicheng. Methods: We collected 26 569 cases, which were coded of C15 and C16 in the 10th edition of international classification of diseases (ICD) during the period of 2000-2013. The data came from cancer registration system of Feicheng, Shandong Province, China. These cases already covered 21 679 882 person-year...
May 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28458519/detection-approaches-for-multidrug-resistance-genes-of-leukemia
#16
REVIEW
Ying Du, Baoan Chen
Leukemia is a clonal malignant hematopoietic stem cell disease. It is the sixth most lethal cancer and accounts for 4% of all cancers. The main form of treatment for leukemia is chemotherapy. While some cancer types with a higher incidence than leukemia, such as lung and gastric cancer, have shown a sharp decline in mortality rates in recent years, leukemia has not followed this trend. Drug resistance is often regarded as the main clinical obstacle to effective chemotherapy in patients diagnosed with leukemia...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28456090/dynamic-evaluation-of-circulating-tumour-cells-in-patients-with-advanced-gastric-and-oesogastric-junction-adenocarcinoma-prognostic-value-and-early-assessment-of-therapeutic-effects
#17
Simon Pernot, Cecile Badoual, Magali Terme, Florence Castan, Aurelie Cazes, Olivier Bouche, Jaafar Bennouna, Eric Francois, Francois Ghiringhelli, Christelle De La Fouchardiere, Emmanuelle Samalin, Jean Baptiste Bachet, Christophe Borg, Michel Ducreux, Elie Marcheteau, Trevor Stanbury, Sophie Gourgou, David Malka, Julien Taieb
BACKGROUND: The identification of dynamic biomarkers in advanced gastric and oesogastric junction adenocarcinoma (GOA) could help to tailor strategies for each patient. Enumeration of circulating tumour cells (CTCs) is approved by the US Food and Drug Administration in breast, colon and prostate cancer but is not in advanced GOA. Our study aims to establish the optimal threshold and the clinical significance of CTC count in advanced GOA before and during treatment. METHODS: One hundred six patients with untreated advanced GOA were included in the ancillary study of the PRODIGE 17-ACCORD 20 trial...
April 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28449423/the-detection-of-messenger-rna-for-carcinoembryonic-antigen-and-cytokeratin-20-in-peritoneal-washing-fluid-in-patients-with-advanced-gastric-cancer
#18
Yeon Ji Kim, Woo Chul Chung, Sooa Choi, Yun Duk Jung, Jaejun Lee, Seung Yun Chae, Kyong Hwa Jun, Hyung Min Chin
Background/Aims: Peritoneal micrometastasis is known to play an important role in the recurrence of gastric cancer. However, its effects remain equivocal. Herein, we examine the messenger RNA (mRNA) as tumor markers, carcinoembryonic antigen (CEA), and cytokeratin 20 (CK20), in peritoneal washing fluid. Moreover, we evaluate whether these results could predict the recurrence of gastric cancer following curative resection. Methods: We prospectively enrolled 132 patients with gastric cancers, who had received an operation, between January 2010 and January 2013...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28445591/screening-endoscopy-finds-high-prevalence-of-helicobacter-pylori-and-intestinal-metaplasia-in-korean-american-with-limited-access-to-health-care
#19
Yanghee Woo, Carolyn E Behrendt, Garrick Trapp, Jae Geun Hyun, Tamas Gonda, Yuman Fong, Timothy Wang
BACKGROUND: Gastric cancer (GC) is the leading cause of cancer death among Korean Americans. Prevention and early detection is improved by screening. METHODS: Between September 2013 and March 2015, ethnic Koreans age 40 or older without history or symptoms of GC and without upper endoscopy (UE) during previous 3 years were enrolled. Participants were offered screening with GC risk assessment followed by UE with biopsies. RESULTS: Risk assessment was provided to 146 participants (age 55...
April 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28424913/can-further-gastrectomy-be-avoided-in-patients-with-incomplete-endoscopic-resection
#20
Hee Sung Kim, Ji Yong Ahn, Seon Ok Kim, Byung Sik Kim
BACKGROUND: Endoscopic resection (ER) is a widely accepted treatment for patients with early gastric cancer (EGC) with no lymph node metastasis. Occasionally, however, additional surgery is needed due to an incomplete resection. The purpose of this study was to detect clinical factors which might identify patients at greater risk of additional surgery after ER and to suggest an alternative treatment strategy for these patients. METHODS: This study retrospectively analyzed 350 patients with gastric cancer who underwent radical gastrectomy and lymphadenectomy after ER in a single institution between July 2004 and July 2014...
April 19, 2017: Surgical Endoscopy
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