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gastric cancer and early detection

Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
Sung Hwa Kang, Young Hoon Kim, Young Hoon Roh, Kwan Woo Kim, Chan Joong Choi, Min Chan Kim, Su Jin Kim, Hee Jin Kwon, Jin Han Cho, Jin Seok Jang, Jong Hun Lee
BACKGROUNDS/AIMS: The aim of this retrospective study is to compare stomach cancer incidence, characteristics between gallstones, cholecystectomy and control groups. It also aims to investigate key variables' potential effects on overall survival. METHODS: A total of 99 patients, diagnosed with stomach cancers between April 1994 and December 2015, were identified. We excluded stomach cancer patients, accrued during the first year of follow-up in both the gallstones and cholecystectomy groups, assuming that they missed cancers...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
Joanna Kruk-Bachonko, Witold Krupski, Michał Czechowski, Ewa Kurys-Denis, Przemysław Mądro, Jadwiga Sierocińska-Sawa, Andrzej Dąbrowski, Grzegorz Wallner, Tomasz Skoczylas
OBJECTIVES: The aim of this research was to examine whether Perfusion Computed Tomography (P-CT) can qualitatively and quantitatively help detect gastric cancer neoangiogenesis in vivo as well as treatment response evaluation. We attempted to explore which P-CT parameters are best used in neoangiogenesis and neoadjuvant therapy for most effective evaluation. We also tried to recognize a positive prediction value of P-CT in early responders and non-responders patients identification. MATERIALS AND METHODS: Twenty-four patients with positive biopsy results and/or clinically proven gastric cancer were enrolled in the P-CT exam...
October 2017: European Journal of Radiology
Fei-Long Ning, Chun-Dong Zhang, Peng Wang, Shuai Shao, Dong-Qiu Dai
BACKGROUND: To compare the efficacy and safety of endoscopic resection (ER) and radical gastrectomy (RG) for early gastric cancer (EGC) in Asia. MATERIALS AND METHODS: We systematically searched relevant articles published before September 1, 2017. We evaluated the quality of the included non-randomized studies using the Newcastle-Ottawa Scale (NOS). Meta-analysis was carried out using RevMan 5.3 software. The odds ratio (OR) with 95% confidence intervals (CI) were used for the dichotomous data...
October 5, 2017: International Journal of Surgery
Najibeh Shekari, Behzad Baradaran, Dariush Shanehbandi, Tohid Kazemi
Gastric cancer (GC) as a global health problem is one of the deadliest cancer all over the world. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause GC as the third lethal cancer in the world. Presence of sensitive and specific biomarkers for early detection and monitoring the progression of GC could lead to the reduction of mortality. MicroRNAs (miRNAs) are gene regulator RNAs play important roles in tumorgenesis. In addition to intracellular miRNAs, circulating miRNAs faithfully reflect the state of cancer progression and provide a promising perspective on early diagnosis of GC...
October 3, 2017: Current Medicinal Chemistry
Yoontaek Lee, Hyung-Ho Kim
The implementation of national cancer screening has increased the detection rates of early gastric cancer (EGC) in Korea. Since the successful introduction of laparoscopic gastrectomy for gastric cancer in the early 1990s, this technique has demonstrated improved short-term outcomes without compromising long-term oncologic results. It is associated with reduced pain, shorter hospitalization, reduced morbidity rates, better cosmetic outcomes, and equivalent mortality rates as those for open surgery. Laparoscopic gastrectomy improves patients' quality of life (QOL) and provides favorable prognosis...
September 2017: Journal of Gastric Cancer
Fu-Rong Wang, Yu-Cai Wei, Zhi-Jian Han, Wen-Ting He, Xiao-Ying Guan, Hao Chen, Yu-Min Li
AIM: To investigate the molecular mechanisms of gastric carcinogenesis. METHODS: We used label-free quantification technology integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify differentially expressed proteins in 160 specimens of normal gastric mucosa, gastric mucosa with mild dysplasia, moderate dysplasia, severe dysplasia, and early mucosal gastric cancer (GC) collected at the Second Hospital of Lanzhou University from 2010 to 2015...
September 7, 2017: World Journal of Gastroenterology: WJG
Masaki Kunizaki, Keiko Hamasaki, Kouki Wakata, Shigekazu Hidaka, Takeshi Nagayasu, Yukie Kinoshita
Serum tumor markers in patients with cancer assist with establishing diagnosis, estimating prognosis, monitoring treatment, and detecting tumor recurrence. Changes in the p53 tumor suppressor gene are the most common genetic abnormalities in many different human malignancies. Several studies have demonstrated that serum p53 antibodies (S-p53Ab) comprise an early marker of malignant disease, a marker for treatment effects and a prognostic factor for patients with several types of tumors. We recently reported that S-p53Ab is useful for patients with gastric cancer...
September 26, 2017: Clinical Journal of Gastroenterology
Jae Yong Park, Sang Gyun Kim, Jung Kim, Seung Jun Han, Sooyeon Oh, Ji Min Choi, Joo Hyun Lim, Hyunsoo Chung, Hyun Chae Jung
BACKGROUND: Metachronous gastric tumor (MGT) is one of major concerns after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Optimal follow-up strategy has not been yet well-established. The aim of this study was to identify the different clinical features of the patients according to the time interval to development of MGT. METHODS: Among 1,780 consecutive patients with EGC who underwent ESD between 2005 and 2014, 115 patients with MGT were retrospectively reviewed...
2017: PloS One
Daisuke Yamaguchi, Shinya Kodashima, Mitsuhiro Fujishiro, Satoshi Ono, Keiko Niimi, Satoshi Mochizuki, Yosuke Tsuji, Itsuko Asada-Hirayama, Yoshiki Sakaguchi, Satoki Shichijo, Chihiro Minatsuki, Nobutake Yamamichi, Kazuhiko Koike
[This corrects the article DOI: 10.1055/s-0043-113632.].
September 2017: Endoscopy International Open
Altin Malaj, Fatmir Bilaj, Albana Shahini, Marjeta Miraka
AIM OF THE STUDY: Gastric adenocarcinoma is among most frequent among cancers in Albania. Early detection and staging is helped by imaging methods, including CT and MRI. This study provides evidence on the CT and MRI accuracy in detecting and pre-operative staging of gastric adenocarcinoma in 62 patients in a diagnostic clinic in Albania. The correct staging of the gastric adenocarcinoma helps decide on the next treatment options. MATERIAL AND METHODS: Sixty-two patients with gastric adenocarcinoma, confirmed with biopsy, underwent both CT and MRI examination at a clinic in Tirana during same week...
2017: Contemporary Oncology Współczesna Onkologia
Elham Kalantari, Mohammad Hossein Asadi Lari, Raheleh Roudi, Alireza Korourian, Zahra Madjd
BACKGROUND: Gastric carcinoma is the third most common malignancy and is one of the main causes of cancer deaths worldwide. Cancer stem cells (CSCs) are a subpopulation of tumour cells capable of self-renewal and differentiation, likely responsible for the initiation, recurrence, metastasis and chemo/radio-resistance. OBJECTIVE: This study was conducted to evaluate the expression patterns and clinicopathologic significance of putative CSC markers, Lgr5 and DCLK1, in gastric carcinoma...
September 15, 2017: Cancer Biomarkers: Section A of Disease Markers
Xin-Xin Liu, Hua Ye, Peng Wang, Yi Zhang, Jian-Ying Zhang
The identification of tumor biomarkers to support early diagnosis and tumor progression monitoring may potentially reduce the mortality of gastric cancer (GC). The present study aimed to detect novel tumor‑associated antigens from the AGS GC cell line, and to identify their associated autoantibodies in sera from patients with GC by proteomics‑based approaches. Proteins from AGS cell lysates were isolated using two‑dimensional polyacrylamide gel electrophoresis, and western blotting was subsequently performed, to determine autoantibody responses in sera derived from patients with GC and healthy individuals...
September 18, 2017: Molecular Medicine Reports
Jing Wang, Lei Zhao, Nina Ma, Juanjuan Che, Huihui Li, Bangwei Cao
RATIONALE: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Although malignant colon and gastric cancer have been reported in CCS, reports of distant metastasis have been rare in CCS...
September 2017: Medicine (Baltimore)
Daisuke Yamaguchi, Shinya Kodashima, Mitsuhiro Fujishiro, Satoshi Ono, Keiko Niimi, Satoshi Mochizuki, Yosuke Tsuji, Itsuko Asada-Hirayama, Yoshiki Sakaguchi, Satoki Shichijo, Chihiro Minatsuki, Nobutake Yamamichi, Kazuhiko Koike
BACKGROUND AND STUDY AIMS : Image-enhanced endoscopy (IEE) plays an important role in early detection and detailed examination of early gastric cancer (EGC). The current study aimed to clarify the efficacy of IEE using advanced diagnostic endoscopy for EGC detection without magnification. PATIENTS AND METHODS : We performed endoscopic examinations without magnification in patients referred to our hospital with a diagnosis of upper gastrointestinal tumor detected through routine screening endoscopy...
September 2017: Endoscopy International Open
A Begum, M A Baten, Z Begum, M M Ahsan, S F Rahman, F Chowdhury, A H Khan
In spite of the global decline in its incidence and mortality, gastric carcinoma still remains a major cause of death due to cancer. Early detection of gastric carcinoma is expected to reduce mortality rates. The applications of measuring of pepsinogen I and pepsinogen II are useful in screening of gastric carcinoma. This cross sectional comparative study was done to find out the correlation of histopathological pattern of gastric carcinoma with serum pepsinogen I & II ratio in the Department of Pathology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh from January 2010 to December 2010...
July 2017: Mymensingh Medical Journal: MMJ
Jihyung Hong, Yiling Tsai, Diego Novick, Frank Chi-Huang Hsiao, Rebecca Cheng, Jen-Shi Chen
BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths in both sexes worldwide, especially in Eastern Asia. This study aimed to estimate the economic burden of advanced gastric cancer (AGC) in Taiwan. METHODS: The costs of AGC in 2013 were estimated using resource use data from a chart review study (n = 122 with AGC) and national statistics. Annual per-patient costs, where patients' follow-up periods were adjusted for, were estimated with 82 patients who had complete resource use data...
September 16, 2017: BMC Health Services Research
Nan Jiang, Haihua Tian, Jinchang Pan, Zhaohui Gong
Long noncoding RNAs (lncRNAs) are involved in vital life processes of gene expression, epigenetic regulation and X-chromosome inactivation. lncRNAs are also closely associated with tumor initiation and progression. Moreover, lncRNAs may enter human circulation system in the form of microvesicle or exosome, or in combination with RNA binding protein. Interestingly, the circulating lncRNAs are widely existed in body fluids, such as blood and urine. We review the origin of circulating lncRNAs, and the detection methods as potential biomarkers...
June 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Safia Fehim, Racheda Bouhaous, Mustapha Diaf, Amine Mokhtar Drici, Meghit Boumediene Khaled
BACKGROUND: Gastric cancer (GC) remains a public health issue despite the global incidence decrease over the last decades. GC is the third leading cause of cancer-related death worldwide and stills of poor prognosis due to its late detection. The overall objective of our study was to describe the epidemiological, clinical, and histopathological aspects of stomach cancer. However, the specific purpose was to determine the gastric precancerous lesions among patients with histologically confirmed GC admitted at the gastroenterology department of the University Hospital of Sidi-Bel-Abbes city, Algeria...
August 2017: Journal of Gastrointestinal Oncology
Osamu Goto, Masayuki Shimoda, Motoki Sasaki, Yoshiyuki Kiguchi, Yutaka Mitsunaga, Teppei Akimoto, Yasutoshi Ochiai, Ai Fujimoto, Tadateru Maehata, Toshihiro Nishizawa, Hiroya Takeuchi, Yuko Kitagawa, Kaori Kameyama, Naohisa Yahagi
BACKGROUND AND AIMS: During endoscopic full-thickness resection (EFTR) for cancers, whether exposure of the lumen to the abdominal cavity during the procedure is acceptable is controversial because of the potential risk of tumor cell seeding. To assess the possibility of transplantation due to contact with tumor cells during the procedure, we prospectively investigated the ability of cancer cells to be detached by touching the tumor surface. METHODS: In 48 patients with a single early gastric cancer resected by endoscopic submucosal dissection, stamp cytology was performed by touching the surface of the specimens to glass slides...
September 7, 2017: Gastrointestinal Endoscopy
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