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Gadoxetic acid

Gavin Low, Harini Dharmana, Samantha Saravana-Bawan, Safwat Girgis
History An asymptomatic 33-year-old woman was referred to the Hepatology Department in 2013 for work-up of indeterminate multifocal liver masses. These lesions were discovered incidentally at multiphase contrast material-enhanced multidetector computed tomography (CT) performed in 2004 to investigate right lower quadrant pain. Imaging surveillance at sporadic intervals revealed slow progressive growth of the lesions over time; however, the number of lesions remained constant. There was no history of cancer, nor were there predisposing factors for chronic liver disease or cirrhosis...
November 2016: Radiology
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi, Motoko Sasaki, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Toshifumi Gabata
Gadoxetic acid is a contrast agent for magnetic resonance (MR) imaging with hepatocyte-specific properties and is becoming increasingly important in detection and characterization of hepatocellular carcinoma and benign hepatocellular nodules, including focal nodular hyperplasia (FNH), nodular regenerative hyperplasia (NRH), hepatocellular adenoma (HCA), and dysplastic nodule. In these hepatocellular nodules, a positive correlation between the grade of membranous uptake transporter organic anion-transporting polypeptide (OATP) 1B3 expression and signal intensity in the hepatobiliary (HB) phase has been verified...
October 14, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Jeong Hee Yoon, Jeong Min Lee, Eunju Kim, Tomoyuki Okuaki, Joon Koo Han
Purpose To determine whether B1 inhomogeneity-corrected volumetric T1 maps of gadoxetic acid-enhanced liver magnetic resonance (MR) imaging are able to demonstrate global liver function and functional heterogeneity in patients with cirrhosis and to investigate their relationship with the development of hepatic insufficiency and decompensation. Materials and Methods This institutional review board-approved retrospective study with waiver of informed consent included 234 consecutive patients who underwent gadoxetic acid-enhanced liver MR imaging, including B1 inhomogeneity-corrected volumetric T1 mapping...
October 3, 2016: Radiology
Paul M Manning, Gavin Hamilton, Kang Wang, Chulhyun Park, Jonathan C Hooker, Tanya Wolfson, Anthony Gamst, William M Haufe, Alex N Schlein, Michael S Middleton, Claude B Sirlin
PURPOSE: To compare agreement between region-of-interest (ROI)- and parametric map-based methods of hepatic proton density fat fraction (PDFF) estimation in adults with known or suspected hepatic steatosis secondary to chronic liver disease over a range of imaging and analysis conditions. MATERIALS AND METHODS: In this IRB approved HIPAA compliant prospective single-site study, 31 adults with chronic liver disease undergoing clinical gadoxetic acid-enhanced liver magnetic resonance imaging at 3 T were recruited...
September 29, 2016: Abdominal Radiology
Sun Young Yim, Beom Jin Park, Soon Ho Um, Na Yeon Han, Deuk Jae Sung, Sung Bum Cho, Seung Hwa Lee, Min Ju Kim, Jin Yong Jung, Jin Dong Kim, Yeon Seok Seo, Dong Sik Kim, Hyonggin An, Yun Hwan Kim
To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with that of computed tomography (CT) during hepatic arteriography and arterial portography (CT HA/AP) for detecting hepatocellular carcinoma (HCC) from small hypervascular nodules.This retrospective study included 38 patients with 131 hypervascular nodules (≤2 cm) who had underwent MRI and CT HA/AP within a 2-week interval. Two observers analyzed MRI while other 2 observers analyzed CT HA/AP. Thereafter, MRI observers reviewed the CT HA/AP and magnetic resonance (MR) images again using both modalities...
September 2016: Medicine (Baltimore)
Thomas D Vreugdenburg, Ning Ma, Joanna K Duncan, Dagmara Riitano, Alun L Cameron, Guy J Maddern
PURPOSE: This systematic review evaluated the diagnostic accuracy and impact on patient management of hepatocyte-specific gadoxetic acid enhanced magnetic resonance imaging (GA-MRI) compared to contrast enhanced computed tomography (CE-CT) in patients with liver metastases. METHOD: Four biomedical databases (PubMed, EMBASE, Cochrane Library, York CRD) were searched from January 1991 to February 2016. Studies investigating the accuracy or management impact of GA-MRI compared to CE-CT in patients with known or suspected liver metastases were included...
November 2016: International Journal of Colorectal Disease
In Young Choi, Seung Soo Lee, Yu Sub Sung, Hyunhee Cheong, Hoyoung Lee, Jae Ho Byun, So Yeon Kim, So Jung Lee, Yong Moon Shin, Moon-Gyu Lee
PURPOSE: To evaluate the value of intravoxel incoherent motion (IVIM) parameters for characterizing focal hepatic lesions, and to assess the correlation between IVIM parameters and arterial nodule enhancement. MATERIALS AND METHODS: We retrospectively evaluated 161 lesions (91 hepatocellular carcinomas [HCCs], 27 intrahepatic cholangiocarcinomas [IHCCs], 20 hemangiomas, 9 combined hepatocellular-cholangiocarcinomas, 9 metastases, and 5 other tumors) in 161 patients (105 men and 56 women; mean age, 56...
September 24, 2016: Journal of Magnetic Resonance Imaging: JMRI
Honsoul Kim, Song-Ee Baek, Jieun Mo On, Yun Ho Roh, Narae Lee, Arthur Cho
PURPOSE: Imaging features of sinusoidal obstruction syndrome (SOS), an increasingly common drawback of chemotherapy, were evaluated via 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT). EXPERIMENTAL DESIGN: This retrospective study was approved by our Institutional Review Board, with a waiver of informed consent. FDG PET/CT studies of 35 patients (male, 24; female, 11; median age, 53.2 years) obtained between January, 2005 and December, 2012 were analyzed before and after systemic chemotherapy...
September 1, 2016: Oncotarget
Li Yang, Ying Ding, Shengxiang Rao, Caizhong Chen, Lifang Wu, Ruofan Sheng, Caixia Fu, Mengsu Zeng
PURPOSE: To assess the accuracy of the T1 relaxation time index on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B (CHB), in comparison and combination with the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4). MATERIALS AND METHODS: A retrospective study of gadoxetic acid-enhanced T1 mapping and serum biochemical tests was performed on 126 CHB patients who underwent gadoxetic acid-enhanced 1...
August 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
Hironao Okubo, Tsuneo Kitamura, Hitoshi Ando, Hiroo Fukada, Yuki Igusa, Shigehiro Kokubu, Akihisa Miyazaki, Akio Fujimura, Shuichiro Shiina, Sumio Watanabe
Simeprevir is a substrate for organic anion-transporting polypeptides (OATPs) that transport bilirubin. Hyperbilirubinemia is an adverse event reported during treatment of chronic hepatitis C patients with simeprevir plus pegylated interferon and ribavirin. Because gadoxetic acid is also a substrate of OATPs, pretreatment gadoxetic acid-enhanced magnetic resonance imaging (MRI) may predict hyperbilirubinemia during treatment. This prospective study therefore evaluated 11 consecutive patients with chronic hepatitis C who underwent gadoxetic acid-enhanced MRI prior to treatment with simeprevir plus pegylated interferon and ribavirin for 12 weeks, followed by pegylated interferon and ribavirin for an additional 12 weeks...
August 17, 2016: Journal of Clinical Pharmacology
Jeong Hee Yoon, Joon-Il Choi, Yong Yeon Jeong, Andrea Schenk, Longquan Chen, Hendrik Laue, So Yeon Kim, Jeong Min Lee
BACKGROUND & AIMS: This study aimed to determine whether the predicted remnant liver function on dynamic hepatocyte-specific contrast media-enhanced magnetic resonance (DHCE-MR) imaging correlates with the results of the indocyanin green retention test (ICG R15) after hepatic resection or radiofrequency ablation (RFA). METHODS: This prospective multicenter study was approved by the Institutional Review Boards of each hospital. Informed consents were obtained from all...
July 28, 2016: Journal of Hepatology
Ijin Joo, Jeong Min Lee, Dong Ho Lee, Su Joa Ahn, Eun Sun Lee, Joon Koo Han
PURPOSE: To investigate the Liver Imaging Reporting and Data System (LI-RADS) v2014 categorization of hepatocellular carcinomas (HCCs) on gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in comparison with multiphasic multidetector computed tomography (MDCT). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study and waived the requirement for informed consent. We included 182 high-risk patients with 216 pathologically confirmed HCCs who underwent both Gd-EOB-MRI at 1...
July 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Ying Ding, Shengxiang Rao, Li Yang, Caizhong Chen, Mengsu Zeng
OBJECTIVE: To evaluate the utility of T1 mapping on gadoxetic acid-enhanced MRI and DWI for staging liver fibrosis and assess the influence of ROI positioning on interobserver variability, T1 relaxation time and ADC value. METHODS: This retrospective study was approved by the institutional review board and included 150 patients (mean age 58 years old; 91 men and 59 women). Liver fibrosis stages (S) were histopathologically determined. T1 relaxation time and ADC value of liver were measured by three distinct ROI protocols (the whole left lobe liver, the whole right lobe liver and the individual ROIs)...
November 2016: La Radiologia Medica
Cecilia Besa, Sara Lewis, Pari V Pandharipande, Jagpreet Chhatwal, Amita Kamath, Nancy Cooper, Ashley Knight-Greenfield, James S Babb, Paolo Boffetta, Norma Padron, Claude B Sirlin, Bachir Taouli
PURPOSE: The purpose of this study was to evaluate the diagnostic performance of a "simulated" abbreviated MRI (AMRI) protocol using diffusion-weighted imaging (DWI) and T1-weighted (T1w) imaging obtained at the hepatobiliary phase (HBP) post gadoxetic acid injection alone and in combination, compared to dynamic contrast-enhanced (CE)-T1w imaging for the detection of hepatocellular carcinoma (HCC). METHODS: This was an IRB approved HIPAA compliant retrospective single institution study including patients with liver disease who underwent gadoxetic acid-enhanced MRI for HCC diagnosis...
July 23, 2016: Abdominal Radiology
Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Eun Ju Kim, Joon Koo Han
OBJECTIVE: To determine whether triple arterial phase acquisition via a combination of Contrast Enhanced Time Robust Angiography, keyhole, temporal viewsharing and parallel imaging can improve arterial phase acquisition with higher spatial resolution than single arterial phase gadoxetic-acid enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Informed consent was waived for this retrospective study by our Institutional Review Board. In 752 consecutive patients who underwent gadoxetic acid-enhanced liver MRI, either single (n = 587) or triple (n = 165) arterial phases was obtained in a single breath-hold under MR fluoroscopy guidance...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Masahiro Tanaka, Yoji Kishi, Minoru Esaki, Satoshi Nara, Mototaka Miyake, Nobuyoshi Hiraoka, Masato Nagino, Kazuaki Shimada
BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) in combination with diffusion-weighted MRI (Gd-EOB-MRI/DWI) has become popular for evaluating colorectal liver metastases (CRLM). This retrospective observational study aimed to determine whether this procedure should be indicated prior to hepatectomy in all patients with CRLM. METHODS: A retrospective survey of relevant data of patients who had undergone hepatectomy for CRLM from 2008 to 2014 was performed...
June 29, 2016: Annals of Surgical Oncology
Shusuke Okamura, Shuji Sumie, Tatsuyuki Tonan, Masahito Nakano, Manabu Satani, Shigeo Shimose, Tomotake Shirono, Hideki Iwamoto, Hajime Aino, Takashi Niizeki, Nobuyoshi Tajiri, Ryoko Kuromatsu, Koji Okuda, Osamu Nakashima, Takuji Torimura
BACKGROUND: Poor differentiation and microvascular invasion are indicators of poor outcome after hepatectomy for patients with small hepatocellular carcinoma (HCC). AIMS: We investigated whether gadoxetic acid-enhanced and diffusion-weighted magnetic resonance imaging (MRI) could predict these factors before hepatectomy. METHODS: Between July 2008 and April 2012, 75 patients who underwent hepatectomy for small HCCs (diameter: ≤3cm, tumor number: ≤3) were consecutively enrolled...
August 2016: Digestive and Liver Disease
Jin Guo, Youngkwon Seo, Shuo Ren, Sunwoo Hong, Dongki Lee, Soyoun Kim, Yuanyuan Jiang
The purpose of this study was to directly (head-to-head) compare the per-lesion diagnostic performance of contrast-enhanced computed tomography (CT) (also referred to as CT hereafter) and gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging (also referred to as MRI hereafter) for the detection of hepatocellular carcinoma (HCC). Studies reporting direct per-lesion comparison data of contrast-enhanced multidetector CT and Gd-EOB-DTPA-enhanced MR imaging that were published between January 2000 and January 2015 were analyzed...
October 2016: Abdominal Radiology
Joanna K Duncan, Ning Ma, Thomas D Vreugdenburg, Alun L Cameron, Guy Maddern
PURPOSE: To establish the relative diagnostic accuracy of gadoxetic acid-enhanced magnetic resonance imaging (GA-MRI) compared with contrast-enhanced computed tomography (CE-CT), dynamic MRI (D-MRI), gadopentetic acid-enhanced MRI (GP-MRI), or gadobenic acid-enhanced MRI (GB-MRI) in the characterization of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, the Cochrane Library, and the University of York CRD databases were searched to February 29 2016 for any studies that compared the diagnostic accuracy of GA-MRI to CE-CT, D-MRI, GP-MRI, or GB-MRI in patients with known or suspected HCC...
June 14, 2016: Journal of Magnetic Resonance Imaging: JMRI
Katsuhiro Sano, Tomoaki Ichikawa, Utaroh Motosugi, Shintaro Ichikawa, Hiroyuki Morisaka, Nobuyuki Enomoto, Masanori Matsuda, Hideki Fujii
OBJECTIVES: To evaluate the longitudinal risk to patients with cirrhosis of hypervascular hepatocellular carcinoma (HCC) developing from hypovascular hepatic nodules that show positive uptake of gadoxetic acid (hyperintensity) on hepatocyte phase images. METHODS: In 69 patients, we evaluated findings from serial follow-up examinations of 633 hepatic nodules that appeared hypovascular and hyperintense on initial gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) until the nodules demonstrated hypervascularity and were diagnosed as hypervascular HCC...
June 2, 2016: European Radiology
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