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Gadoxetic acid

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https://www.readbyqxmd.com/read/28292007/magnetic-resonance-imaging-for-colorectal-cancer-metastasis-to-the-liver-comparative-effectiveness-research-for-the-choice-of-contrast-agents
#1
Nieun Seo, Mi-Suk Park, Kyunghwa Han, Kyung Ho Lee, Seong Ho Park, Gi Hong Choi, Jin-Young Choi, Yong Eun Chung, Myeong-Jin Kim
Purpose: This study was conducted to compare the diagnostic performance and early recurrence rate between gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) and MRI with extracellular contrast agent (ECA-MRI) for evaluating hepatic lesions in colorectal cancer. Materials and Methods: Between 2005 and 2010, 418 colorectal cancer patients with both preoperative computed tomography (CT) and liver MRI were retrospectively reviewed. Image analysis was based on initial radiologic reports, and diagnostic performance was assessed based on the area under the receiver operating characteristic curve (AUROC)...
March 14, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28289936/comparison-of-spin-echo-echoplanar-imaging-and-gradient-recalled-echo-based-mr-elastography-at-3-tesla-with-and-without-gadoxetic-acid-administration
#2
Yong Seek Kim, Ji Soo Song, Stephan Kannengiesser, Seung Young Seo
OBJECTIVE: To compare spin-echo echoplanar imaging (SE-EPI) and gradient recalled echo (GRE) MR elastography (MRE) at 3 T with and without gadoxetic acid administration. METHODS: We included 84 patients who underwent MRE before and after gadoxetic acid administration, each time using SE-EPI and GRE sequences. Diagnostic performance for predicting clinical liver cirrhosis and high-risk oesophageal varices was assessed using the area under the receiver-operating characteristic curve (AUC)...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28274510/can-contrast-enhanced-mri-with-gadoxetic-acid-predict-liver-failure-and-other-complications-after-major-hepatic-resection
#3
A F Costa, A Tremblay St-Germain, M Abdolell, R L Smoot, S Cleary, K S Jhaveri
AIM: To determine whether a combination of clinical factors, the future liver remnant (FLR) ratio, and hepatic uptake of gadoxetic acid can be used to predict post-hepatectomy liver failure (PHLF) and other major complications (OMC). MATERIALS AND METHODS: Sixty-five consecutive patients who underwent pre-hepatectomy gadoxetic acid-enhanced magnetic resonance imaging (MRI) between October 2010 and December 2013 were included. The relative liver enhancement (RLE) of gadoxetic acid was calculated from regions of interest on MRI, and FLR ratios were obtained from computed tomography (CT)...
March 5, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28267535/the-value-of-paradoxical-uptake-of-hepatocellular-carcinoma-on-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging-for-the-prediction-of-lipiodol-uptake-after-transcatheter-arterial-chemoembolization
#4
Jeong Woo Kim, Chang Hee Lee, Yang Shin Park, Tae Seok Seo, Myung Gyu Song, Ji Hoon Kim, Kyeong Ah Kim, Cheol Min Park
PURPOSE: To compare the response to transcatheter arterial chemoembolization (TACE) between hepatocellular carcinoma (HCC) with paradoxical uptake on the hepatobiliary phase (HBP) (HCCpara) and HCC with defect on the HBP (HCCdef), and to identify some imaging features that can differentiate between two groups. MATERIALS AND METHODS: Ninety-three HCCs from 54 patients who underwent gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) prior to TACE were included...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28251499/comparison-of-gadoxetic-acid-enhanced-dynamic-mr-imaging-and-contrast-enhanced-computed-tomography-for-preoperative-evaluation-of-colorectal-liver-metastases
#5
Nobuyuki Asato, Masakatsu Tsurusaki, Keitaro Sofue, Yoko Hieda, Takashi Katsube, Kazuhiro Kitajima, Takamichi Murakami
PURPOSE: To evaluate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) vs. contrast-enhanced computed tomography (CE-CT) in the detection of liver metastasis in colorectal carcinoma patients. MATERIALS AND METHODS: One-hundred fifty-eight consecutive patients with histopathologically confirmed colorectal carcinoma underwent EOB-MRI and CE-CT; 68 patients had 105 surgically confirmed liver metastases. Diagnostic analyses were performed according to sensitivity and positive predictive value (PPV) for liver metastasis detection in combined arterial- and hepatocyte-phase images vs...
March 1, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28240637/correlation-between-bile-reflux-gastritis-and-biliary-excreted-contrast-media-in-the-stomach
#6
Jong Jin Hyun, Suk Keu Yeom, Euddeum Shim, Jaehyung Cha, Inyoung Choi, Seung Hwa Lee, Hwan Hoon Chung, Sang Hoon Cha, Chang Hee Lee
OBJECTIVE: This study aimed to evaluate the relationship between biliary excreted contrast media in the stomach and the presence of bile reflux gastritis. METHODS: Consecutive 111 patients who underwent both gadoxetic acid-enhanced magnetic resonance cholangiography (gadoxetic MRC) and gastric endoscopy were included in this study. We performed a review of the gadoxetic-MRC image sets acquired 60 minutes after intravenous injection of contrast media and endoscopic images...
February 24, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28195932/contrast-agent-induced-high-signal-intensity-in-dentate-nucleus-on-unenhanced-t1-weighted-images-comparison-of-gadodiamide-and-gadoxetic-acid
#7
Shintaro Ichikawa, Utaroh Motosugi, Yoshie Omiya, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate whether an association exists between T1-signal increase in the dentate nucleus (DN) on unenhanced magnetic resonance imaging and previous administration of gadoxetic acid and gadodiamide. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. A total of 132 patients (male-female ratio, 86:46; mean age, 68.8 ± 11.6 years) who underwent imaging between December 2000 and April 2016 were divided into 4 groups: patients with 5 or more administrations of gadoxetic acid ("gadoxetic acid ≥5 administrations" group), only 1 administration of gadoxetic acid ("gadoxetic acid 1 administration" group), no gadolinium-based contrast agent (GBCA) administration or chronic liver disease (CLD; "no GBCA administration and no CLD" group), and 5 or more administrations of gadodiamide ("gadodiamide ≥5 administrations" group)...
February 11, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28190852/characteristics-of-hepatic-schwannoma-presenting-as-an-unusual-multi-cystic-mass-on-gadoxetic-acid-disodium-enhanced-mr-imaging
#8
Hiroki Haradome, Jun Woo, Hisashi Nakayama, Haruna N Watanabe, Masahiro Ogawa, Mitsuhiko Moriyama, Masahiko Sugitani, Tadatoshi Takayama, Osamu Abe
Hepatic schwannoma is a very rare hepatic tumor, usually appearing as a hypervascular solid mass with or without various degrees of cystic changes; however, to the best of our knowledge, only the two cases of hepatic schwannoma showing a multi-cystic appearance have previously been reported. We report herein a benign hepatic schwannoma presenting as an unusually large multi-cystic mass. The gadoxetic acid disodium-enhanced magnetic resonance imaging features are described with the histopathologic correlation and briefly review the literature...
February 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28181333/respiratory-motion-artifacts-during-arterial-phase-imaging-with-gadoxetic-acid-can-the-injection-protocol-minimize-this-drawback
#9
Stephan H Polanec, Hubert Bickel, Pascal A T Baltzer, Patrick Thurner, Florian Gittler, Jacqueline C Hodge, Mustafa R Bashir, Ahmed Ba-Ssalamah
PURPOSE: To determine which of three gadoxetic acid injection techniques best reduced the contrast-related arterial-phase motion artifacts. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, retrospective study included a cohort of 78 consecutive patients who each had serial gadoxetic acid-enhanced 3.0T magnetic resonance imaging (MRI) of the liver (0.025 mmol/kg body weight) performed with at least two of three injection techniques: M1 test bolus, undiluted, power-injected 1 mL/s; M2 test bolus, diluted 50% with saline, power-injected 1 mL/s; M3 fixed delay, undiluted, manually injected...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28163295/shrunken-hepatic-hemangioma-following-delineated-peritumoral-hyperintensity-on-gadoxetic-acid-disodium-enhanced-mr-imaging
#10
Hiroki Haradome, Takao Okubo, Yusuke Toda, Jun Woo, Tadatoshi Takayama, Osamu Abe
No abstract text is available yet for this article.
February 6, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28153667/quantitative-analysis-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-predicts-histological-grade-of-hepatocellular-carcinoma
#11
Hong-Fei Tong, Hong-Bo Liang, Zhi-Kang Mo, Tian-Pei Guan, Jian Yang, Chi-Hua Fang
OBJECTIVE: To confirm the histological grade of hepatocellular carcinoma (HCC) by gadoxetic acid-enhanced MRI. METHODS: Ninety-five HCC patients underwent gadoxetic acid-enhanced MRI before surgical intervention. The correlations among the signal absolute enhancement, contrast enhancement ratio (CER) and tumor histological grade were analyzed. RESULTS: The correlation between CER of tumor-to-liver and the grades of tumor differentiation is the most significant negative...
January 11, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#12
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28076722/is-there-long-term-signal-intensity-increase-in-the-central-nervous-system-on-t1-weighted-images-after-mr-imaging-with-the-hepatospecific-contrast-agent-gadoxetic-acid-a-cross-sectional-study-in-91-patients
#13
Johannes Kahn, Helena Posch, Ingo G Steffen, Dominik Geisel, Christian Bauknecht, Thomas Liebig, Timm Denecke
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1...
March 2017: Radiology
https://www.readbyqxmd.com/read/28026208/mri-of-small-hepatocellular-carcinoma-typical-features-are-less-frequent-below-a-size-cutoff-of-1-5-cm
#14
Moon Hyung Choi, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Sung Eun Rha, Chandana Lall
OBJECTIVE: The purposes of this study were to analyze MRI features of small hepatocellular carcinomas (HCCs) on the basis of size and to evaluate the difference in frequency of typical radiologic hallmarks of HCC (arterial enhancement and washout) according to the tumor size. MATERIALS AND METHODS: Enrolled were 86 patients with 110 HCCs 3 cm or smaller who underwent surgical resection or transplantation. Two radiologists reviewed gadoxetic acid-enhanced MRI features for signal intensity of T2-weighted and T1-weighted imaging, diffusion restriction, presence of arterial enhancement, washout on portal and transitional phases, and signal intensity on the hepatobiliary phase...
March 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28002336/the-utility-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-in-the-surveillance-for-postoperative-recurrence-of-hepatocellular-carcinoma
#15
Jung Hee Kim, Yang Won Min, Geum-Youn Gwak, Yong Han Paik, Moon Seok Choi, Joon Hyoek Lee, Kwang Cheol Koh, Seung Woon Paik
This study aimed to investigate the utility of gadoxetic acid-enhanced magnetic resonance imaging (Gd-MRI) in surveillance for recurrent hepatocellular carcinoma (HCC) after hepatectomy.This retrospective study analyzed 147 patients who underwent surveillance with alternating multidetector computed tomography (MDCT) and Gd-MRI after hepatectomy for HCC. The patients were followed-up every 3 months during the first 2 years, and every 6 months thereafter. At each visit, MDCT was performed but once a year (every 12 months), Gd-MRI was performed instead of MDCT...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27986174/avoiding-pitfalls-in-the-interpretation-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#16
Marco Dioguardi Burgio, Maxime Ronot, Luisa Paulatto, Sylvain Terraz, Valérie Vilgrain, Giuseppe Brancatelli
Gadoxetic acid is extensively used in the following 3 main clinical situations: characterization of small nodules in patients with cirrhosis, preoperative staging of liver metastases, and characterization of incidentally discovered focal liver lesions. Owing to the rapid entry of gadoxetic acid into hepatocytes, the traditional features of liver tumors are modified on magnetic resonance (MR) imaging, especially during delayed phase sequences. Thus, although the added value of gadoxetic acid for the detection and characterization of focal liver lesions is now clear, its unique pharmacokinetics as well as the presence of mimicking and atypical lesions may lead to misdiagnoses...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986173/liver-function-assessment-by-magnetic-resonance-imaging
#17
Emre Ünal, Deniz Akata, Musturay Karcaaltincaba
Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27977329/reducing-artifacts-during-arterial-phase-of-gadoxetate-disodium-enhanced-mr-imaging-dilution-method-versus-reduced-injection-rate
#18
Young Kon Kim, Wei-Chan Lin, Kyunghyun Sung, Steven S Raman, Daniel Margolis, Yaeji Lim, Seonhye Gu, David Lu
Purpose To compare two contrast material-administration protocols (dilution vs slow injection) in terms of their effectiveness in arterial phase artifact reduction at gadoxetic acid-enhanced magnetic resonance (MR) imaging. Materials and Methods This HIPAA-compliant retrospective case-controlled cohort study was approved by the institutional review board, with a waiver of informed patient consent. A total of 318 consecutive patients undergoing gadoxetic acid-enhanced MR imaging were placed into one of two subcohorts of 159 consecutive patients each: the dilution subcohort (gadoxetic acid was diluted 1:1 with saline and injected at a rate of 2...
December 15, 2016: Radiology
https://www.readbyqxmd.com/read/27957635/gadoxetic-acid-enhanced-magnetic-resonance-imaging-characteristics-of-hepatocellular-carcinoma-occurring-in-liver-transplants
#19
Mimi Kim, Tae Wook Kang, Woo Kyoung Jeong, Young Kon Kim, Seong Hyun Kim, Jong Man Kim, Dong Hyun Sinn, Min-Ji Kim, Sin-Ho Jung
OBJECTIVES: Characteristics of hepatocellular carcinoma (HCC) on magnetic resonance (MR) images were compared in patients who did or did not undergo liver transplantation (LT), and we evaluated the relationship of these findings with overall survival (OS) and time-to-tumour recurrence (TTR) after transplantation. METHODS: The enhancement pattern of gadoxetic acid-enhanced MR images of 25 patients with recurrent HCCs (LT group) and 25 surgically confirmed HCC patients in the non-transplanted (control) group were compared...
December 12, 2016: European Radiology
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#20
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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