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Gadoxetic acid

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https://www.readbyqxmd.com/read/29335868/added-value-of-ancillary-imaging-features-for-differentiating-scirrhous-hepatocellular-carcinoma-from-intrahepatic-cholangiocarcinoma-on-gadoxetic-acid-enhanced-mr-imaging
#1
Seo-Youn Choi, Young Kon Kim, Ji Hye Min, Tae Wook Kang, Woo Kyoung Jeong, Soohyun Ahn, Hojeong Won
OBJECTIVES: To determine ancillary features that help distinguish between scirrhous hepatocellular carcinoma (S-HCC) and intrahepatic cholangiocarcinoma (ICC) and investigate added value of ancillary features to enhancement pattern-based diagnosis on gadoxetic acid-enhanced MRI. METHODS: This retrospective study included 96 patients with S-HCCs and 120 patients with ICCs who underwent gadoxetic acid MRI before surgical resection. Two observers reviewed MRIs of the tumours...
January 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#2
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29260280/peri-tumoral-hyperintensity-on-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-hepatocellular-carcinomas-correlation-with-peri-tumoral-hyperplasia-and-its-pathological-features
#3
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Takahiro Komori, Kazuto Kozaka, Hiroko Ikeda, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: Peri-tumoral hyperintensity (P-hyperintensity) is occasionally seen in hepatocellular carcinoma (HCC) on the hepatobiliary (HB) phase of gadoxetic acid-enhanced MRI (EOB-MRI). A recent study reported peri-tumoral hyperplasia (P-hyperplasia) associated with over-expression of glutamine synthetase (GS) in HCC or metastatic carcinoma. The aim of this study was to analyze the correlation between P-hyperintensity on the HB phase and GS expression indicating P-hyperplasia and reveal its pathological features...
December 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29244853/limited-detection-of-small-%C3%A2-10-mm-colorectal-liver-metastasis-at-preoperative-ct-in-patients-undergoing-liver-resection
#4
Yousun Ko, Jihang Kim, Joseph Kyu-Hyung Park, Haeryoung Kim, Jai Young Cho, Sung-Bum Kang, Soyeon Ahn, Kyong Joon Lee, Kyoung Ho Lee
OBJECTIVE: To retrospectively determine the sensitivity of preoperative CT in the detection of small (≤ 10 mm) colorectal liver metastasis (CRLM) nodules in patients undergoing liver resection. METHODS: The institutional review board approved the study and waived informed consent. We included 461 pathologically confirmed CRLM nodules in 211 patients (including 71 women; mean age, 66.4 years) who underwent 229 liver resections following abdominal CT. Prior to 163 resections, gadoxetic acid-enhanced liver MR imaging was also performed...
2017: PloS One
https://www.readbyqxmd.com/read/29239710/liver-fibrosis-deep-convolutional-neural-network-for-staging-by-using-gadoxetic-acid-enhanced-hepatobiliary-phase-mr-images
#5
Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Osamu Abe, Shigeru Kiryu
Purpose To investigate the performance of a deep convolutional neural network (DCNN) model in the staging of liver fibrosis using gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) imaging. Materials and Methods This retrospective study included patients for whom input data (hepatobiliary phase MR images, static magnetic field of the imaging unit, and hepatitis B and C virus testing results available, either positive or negative) and reference standard data (liver fibrosis stage evaluated from biopsy or surgical specimens obtained within 6 months of the MR examinations) were available were assigned to the training (534 patients) or the test (100 patients) group...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#6
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29221964/inflammatory-hepatic-adenomas-characterization-with-hepatobiliary-mri-contrast-agents
#7
James F Glockner, Christine U Lee, Taofic Mounajjed
PURPOSE: To characterize the MRI appearance of inflammatory hepatic adenomas using hepatobiliary contrast agents. MATERIALS AND METHODS: MRI was performed using hepatobiliary contrast agents (3 with gadobenate dimeglumine and 24 with gadoxetic acid) in 27 patients with immunohistochemistry-confirmed diagnosis of inflammatory hepatic adenoma. The appearance of the lesions on T2 and diffusion-weighted images, pre-gadolinium T1-weighted images, dynamic post-gadolinium images, and hepatobiliary phase images was assessed...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29193508/detection-of-liver-fibrosis-using-qualitative-and-quantitative-mr-elastography-compared-to-liver-surface-nodularity-measurement-gadoxetic-acid-uptake-and-serum-markers
#8
Cecilia Besa, Mathilde Wagner, Grace Lo, Sonja Gordic, Manjil Chatterji, Paul Kennedy, Ashley Stueck, Swan Thung, James Babb, Andrew Smith, Bachir Taouli
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) combining different techniques such as MR elastography (MRE) has emerged as a noninvasive approach to diagnose and stage liver fibrosis with high accuracy allowing for anatomical and functional information. PURPOSE: To assess the diagnostic performance of mpMRI including qualitative and quantitative assessment of MRE, liver surface nodularity (LSN) measurement, hepatic enhancement ratios postgadoxetic acid, and serum markers (APRI, FIB-4) for the detection of liver fibrosis...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29189403/how-do-different-indices-of-hepatic-enhancement-with-gadoxetic-acid-compare-in-predicting-liver-failure-and-other-major-complications-after-hepatectomy
#9
Andreu F Costa, Amélie Tremblay St-Germain, Mohamed Abdolell, Rory L Smoot, Sean Cleary, Kartik S Jhaveri
OBJECTIVE: The objective of this study was to assess the accuracy of gadoxetic acid hepatic enhancement indices in predicting posthepatectomy liver failure (PHLF) and other major complications (OMCs). METHODS: Sixty-five patients underwent prehepatectomy gadoxetic acid-enhanced magnetic resonance imaging. Enhancement indices were calculated by obtaining regions of interest on magnetic resonance images and segmented volumes of the liver and spleen. Multivariate regression analysis was performed to predict PHLF and OMC as a function of the indices, and areas under the receiver operator characteristic (AUROC) curves were calculated...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#10
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29128992/mapping-of-hepatic-vasculature-in-potential-living-liver-donors-comparison-of-gadoxetic-acid-enhanced-mr-imaging-using-caipirinha-technique-with-ct-angiography
#11
Kartik Jhaveri, Lijun Guo, Luís Guimarães, Ravi Menezes, Ian McGilvray, Mark Cattral, David Grant
PURPOSE: To retrospectively evaluate gadoxetic acid-enhanced magnetic resonance angiography (MRA) using controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique for mapping hepatic vascular anatomy in potential living liver donors, with CT angiography (CTA) as reference standard. METHODS: 82 potential living liver donors who underwent MRA and CTA were enrolled in this HIPAA-compliant IRB-approved study. MRA and CTA images were evaluated by two reviewers in consensus with respect to (1) image quality scores for depiction of the hepatic vessels and (2) accuracy of MRA for determining the hepatic vascular variants with CTA as reference standard...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29116626/unclassified-hepatocellular-adenoma-in-a-middle-aged-woman-with-glucose-intolerance
#12
Kumi Ozaki, Kenichi Harada, Toru Yamamoto, Hiroyuki Aoyagi, Yasuharu Kaizaki, Jun Yoshikawa
The patient was a 43-year-old woman with obesity (body mass index: 29.1) and glucose intolerance who was not taking oral contraceptives. An ultrasound showed a hypoechoic hepatic mass. Dynamic contrast-enhanced computed tomography revealed a lesion in segment 6 that showed homogeneous and slight-to-moderate enhancement in the arterial phase with persistent enhancement during the portal and equilibrium phases. On magnetic resonance (MR) imaging, the lesion demonstrated hyperintensity on T2- and diffusion-weighted images and hypointensity in the hepatobiliary phase of gadoxetic-acid-enhanced MR imaging...
November 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29091004/performing-gadoxetic-acid-enhanced-mri-after-ct-for-guiding-curative-treatment-of-early-stage-hepatocellular-carcinoma-a-cost-effectiveness-analysis
#13
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, So Yeon Kim, Dong-Cheol Woo, Sangjin Shin, Junhee Pyo, Atul B Shinagare, Nikhil H Ramaiya, Young-Suk Lim
OBJECTIVE: We determined the cost-effectiveness of two different diagnostic imaging strategies in guiding curative treatment of early-stage hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We developed a decision analytic model using as its starting point a cohort of patients aged 55 years with early-stage HCC detected at dynamic multiphasic CT and with Child-Pugh class A cirrhosis. The model compared two strategies on the initial workup: conventional CT strategy using dynamic multiphasic CT only and gadoxetic acid-enhanced MRI strategy using additional gadoxetic acid-enhanced MRI after initial CT...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#14
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29063251/management-of-subcentimetre-arterially-enhancing-and-hepatobiliary-hypointense-lesions-on-gadoxetic-acid-enhanced-mri-in-patients-at-risk-for-hcc
#15
Chae Jung Park, Chansik An, Sumi Park, Jin-Young Choi, Myeong-Jin Kim
OBJECTIVES: To investigate the significance of subcentimetre (≤1 cm) arterially enhancing and hepatobiliary hypointense lesions (SAELs) observed on gadoxetic acid-enhanced magnetic resonance imaging (MRI) of patients at risk of hepatocellular carcinoma (HCC). METHODS: A SAEL was defined as a subcentimetre hypervascular nodule exhibiting a hepatobiliary phase defect on gadoxetic acid-enhanced MRI. We included 52 SAELs from 46 patients in a HCC surveillance population...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29050339/aberrant-expression-of-oatp1b3-in-colorectal-cancer-liver-metastases-and-its-clinical-implication-on-gadoxetic-acid-enhanced-mri
#16
Seung Hyun Park, Honsoul Kim, Eun Kyung Kim, Hogeun Kim, Dong Kyu Choi, Yong Eun Chung, Myeong-Jin Kim, Jin-Young Choi
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29023687/a-guide-for-effective-anatomical-vascularization-studies-useful-ex%C3%A2-vivo-methods-for-both-ct-and-mri-imaging-before-dissection
#17
Yohann Renard, Gabriela Hossu, Bailiang Chen, Marine Krebs, Marc Labrousse, Manuela Perez
The objective of this study was to develop a simple and useful injection protocol for imaging cadaveric vascularization and dissection. Mixtures of contrast agent and cast product should provide adequate contrast for two types of ex vivo imaging (MRI and CT) and should harden to allow gross dissection of the injected structures. We tested the most popular contrast agents and cast products, and selected the optimal mixture composition based on their availability and ease of use. All mixtures were first tested in vitro to adjust dilution parameters of each contrast agent and to fine-tune MR imaging acquisition sequences...
October 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28987693/association-between-non-hypervascular-hypointense-nodules-on-gadoxetic-acid-enhanced-mri-and-liver-stiffness-or-hepatocellular-carcinoma
#18
Jeong Ah Hwang, Tae Wook Kang, Young Kon Kim, Seong Hyun Kim, Yong Han Paik, Sang Yun Ha, Seonwoo Kim
PURPOSE: To assess the association between non-hypervascular hypointense nodules (NHHNs) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and liver stiffness (LS) in patients with chronic liver disease, and analyzed their progression to overt hepatocellular carcinoma (HCC). METHODS: Between August 2012 and March 2016, a total of 714 consecutive patients who had undergone transient elastography for LS measurement and gadoxetic acid-enhanced MRI were investigated...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987688/differentiation-of-hypointense-nodules-on-gadoxetic-acid-enhanced-hepatobiliary-phase-mri-using-t2-enhanced-spin-echo-imaging-with-the-time-reversed-gradient-echo-sequence-an-initial-experience
#19
Masami Yoneyama, Yukihisa Takayama, Akihiro Nishie, Masanobu Nakamura, Yasutomo Katsumata, Atsushi Takemura, Makoto Obara, Tomoyuki Okuaki, Hiroshi Honda, Marc Van Cauteren
PURPOSE: To optimize the flip angle (FA) of the T2 enhanced spin-echo imaging using the time reversed gradient echo (T2FFE) and evaluate its utility for differentiating hypointensity nodules in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced (Gd-EOB) MRI. MATERIALS AND METHODS: First, FA optimization of the T2FFE in the HBP was investigated by comparing signal-to-noise ratio (SNR) among different FAs using phantoms. The liver-to-muscle contrast ratios (CRLiver-Muscle) and image quality among three FAs (20°, 50° and 80°) were compared using images of 10 patients...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987012/predicting-post-hepatectomy-liver-failure-by-combined-volumetric-functional-mr-image-and-laboratory-analysis
#20
Yi-Hsuan Chuang, Hsin-You Ou, Marirose Z Lazo, Chao-Long Chen, Meng-Hsiang Chen, Ching-Chun Weng, Yu-Fan Cheng
BACKGROUND & AIMS: To assess the efficacy of functional MR image with volumetric, liver function test and indocyanine green clearance (ICG) in identifying the patients who are at risk of post-hepatectomy liver failure (PHLF). METHODS: We retrospectively included 115 patients undergoing gadoxetic acid-enhanced MR imaging before hepatectomy at one medical centre from January 2013 to December 2015. Contrast enhancement ratio (CER) between transitional and hepatobiliary phases (3 and 30 minutes post-contrast) was calculated...
October 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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