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Gadoxetic acid

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https://www.readbyqxmd.com/read/29767320/post-hepatectomy-liver-failure-after-major-hepatic-surgery-not-only-size-matters
#1
Ulrika Asenbaum, Klaus Kaczirek, Ahmed Ba-Ssalamah, Helmut Ringl, Christoph Schwarz, Fredrik Waneck, Fabian Fitschek, Christian Loewe, Richard Nolz
OBJECTIVES: To compare the value of functional future liver remnant (functFLR) to established clinical and imaging variables in prediction of post-hepatectomy liver failure (PHLF) after major liver resection. METHODS: This retrospective, cross-sectional study included 62 patients, who underwent gadoxetic acid enhanced MRI and MDCT within 10 weeks prior to resection of ≥ 4 liver segments. Future liver remnant (FLR) was measured in MDCT using semi-automatic software...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29709031/gadoxetic-acid-enhanced-magnetic-resonance-imaging-to-predict-paritaprevir-induced-hyperbilirubinemia-during-treatment-of-hepatitis-c
#2
Hironao Okubo, Hitoshi Ando, Yushi Sorin, Eisuke Nakadera, Hiroo Fukada, Junichi Morishige, Akihisa Miyazaki, Kenichi Ikejima
BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. Hyperbilirubinemia is an adverse event reported during hepatitis C treatment. Gadoxetic acid is also transported by OATP1B1/1B3. We evaluated whether the enhancement effect in gadoxetic acid-enhanced magnetic resonance (MR) imaging could predict the plasma concentration of paritaprevir and might anticipate the development of hyperbilirubinemia. METHODS: This prospective study evaluated 27 patients with hepatitis C who underwent gadoxetic acid-enhanced MR imaging prior to treatment with ombitasvir, paritaprevir, and ritonavir...
2018: PloS One
https://www.readbyqxmd.com/read/29708786/differentiation-between-hepatocellular-carcinoma-showing-hyperintensity-on-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-and-focal-nodular-hyperplasia-by-ct-and-mri
#3
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Ryuichi Kita, Kazuto Kozaka, Satoshi Kobayashi, Toshifumi Gabata
OBJECTIVE: The purpose of this study is to identify points useful in the imaging differentiation of hepatocellular carcinoma (HCC) showing hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI and focal nodular hyperplasia (FNH) and FNH-like nodules. MATERIALS AND METHODS: We enrolled consecutive 51 pathologically diagnosed HCCs that were hyperintense on hepatobiliary phase imaging (47 patients, including 44 with cirrhosis) and 10 FNHs and eight FNH-like nodules (16 patients, including five with cirrhosis)...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29704934/liver-enhancement-in-healthy-dogs-after-gadoxetic-acid-administration-during-dynamic-contrast-enhanced-magnetic-resonance-imaging
#4
P Borusewicz, E Stańczyk, K Kubiak, J Spużak, K Glińska-Suchocka, M Jankowski, J Nicpoń, P Podgórski
Dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) consists of acquisition of native baseline images, followed by a series of acquisitions performed during and after administration of a contrast medium. DCE-MRI, in conjunction with hepatobiliary-specific contrast media, such as gadoxetic acid (GD-EOB-DTPA), allows for precise characterisation of the enhancement pattern of the hepatic parenchyma following administration of the contrast agent. The aim of the study was to assess the pattern of temporal resolution contrast enhancement of the hepatic parenchyma following administration of GD-EOB-DTPA and to determine the optimal time window for post-contrast assessment of the liver...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29691635/clinical-impact-of-preoperative-liver-mri-in-the-evaluation-of-synchronous-liver-metastasis-of-colon-cancer
#5
Cherry Kim, So Yeon Kim, Min-Ju Kim, Yong Sik Yoon, Chan Wook Kim, Jae Hoon Lee, Kyu-Pyo Kim, Seung Soo Lee, Seong Ho Park, Moon-Gyu Lee
OBJECTIVES: To investigate whether additional MRI including gadoxetic acid enhancement is associated with survival rate (SR) in patients with synchronous liver metastasis of colon cancer (sCLM), compared with patients assessed only with CT. METHODS: Fifty-two patients underwent only CT (CT group) and 65 underwent additional MRI (CT+MRI group) for preoperative work-up of sCLM. In the CT+MRI group, the discrepancy between CT and MRI was analyzed. The 5-year SR was compared between the groups, and affecting factors were investigated...
April 24, 2018: European Radiology
https://www.readbyqxmd.com/read/29675932/quantification-of-liver-function-by-linearization-of-a-two-compartment-model-of-gadoxetic-acid-uptake-using-dynamic-contrast-enhanced-magnetic-resonance-imaging
#6
Josiah Simeth, Adam Johansson, Dawn Owen, Kyle Cuneo, Michelle Mierzwa, Mary Feng, Theodore S Lawrence, Yue Cao
Dynamic gadoxetic acid-enhanced magnetic resonance imaging (MRI) allows the investigation of liver function through the observation of the perfusion and uptake of contrast agent in the parenchyma. Voxel-by-voxel quantification of the contrast uptake rate (k1 ) from dynamic gadoxetic acid-enhanced MRI through the standard dual-input, two-compartment model could be susceptible to overfitting of variance in the data. The aim of this study was to develop a linearized, but more robust, model. To evaluate the estimated k1 values using this linearized analysis, high-temporal-resolution gadoxetic acid-enhanced MRI scans were obtained in 13 examinations, and k1 maps were created using both models...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29666951/predicting-chemotherapeutic-response-for-colorectal-liver-metastases-using-relative-tumor-enhancement-of-gadoxetic-acid-disodium-enhanced-magnetic-resonance-imaging
#7
Shinichi Murata, Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Takaaki Hasegawa, Kei Muro, Yoshitaka Inaba
PURPOSE: This study aimed to predict the treatment response for colorectal liver metastases (CLM) using relative tumor enhancement (RTE) of the hepatobiliary phase (HBP) for patients with no history of chemotherapy. MATERIALS AND METHODS: In this retrospective study, we enrolled 26 patients [14 males, 12 females; median age: 58 years (range 37-82 years)] with CLM and no history of chemotherapy between December 2011 and May 2017. Gadoxetic acid-enhanced magnetic resonance imaging was performed before starting chemotherapy and RTE of HBP...
April 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29532241/gd-eob-dtpa-enhanced-t1-relaxometry-for-assessment-of-liver-function-determined-by-real-time-13-c-methacetin-breath-test
#8
Michael Haimerl, Irene Fuhrmann, Stefanie Poelsterl, Claudia Fellner, Marcel D Nickel, Kilian Weigand, Marc H Dahlke, Niklas Verloh, Christian Stroszczynski, Philipp Wiggermann
OBJECTIVES: To determine whether liver function as determined by intravenous administration of 13 C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. METHODS: Sixty-six patients underwent a 13 C-methacetin breath test (13 C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29526882/thin-slice-free-breathing-pseudo-golden-angle-radial-stack-of-stars-with-gating-and-tracking-t1-weighted-acquisition-an-efficient-gadoxetic-acid-enhanced-hepatobiliary-phase-imaging-alternative-for-patients-with-unstable-breath-holding
#9
Kimihiro Kajita, Satoshi Goshima, Yoshifumi Noda, Hiroshi Kawada, Nobuyuki Kawai, Tomoyuki Okuaki, Masatoshi Honda, Masayuki Matsuo
PURPOSE: To compare four free-breathing scan techniques for gadoxetic acid-enhanced hepatobiliary phase imaging with conventional breath-hold scans. MATERIALS AND METHODS: Gadoxetic acid-enhanced hepatobiliary phase imaging with six image acquisition sets performed in 50 patients. Image acquisition sets included fat-suppressed 3D T1 -weighted turbo field echo with free-breathing pseudo-golden-angle radial stack-of-stars (FBRS) acquisition, FBRS with track (FBRST ), FBRS with gate and track (FBRSG&T ), thin-slice FBRS with gate and track (thin-slice FBRSG&T ), free-breathing Cartesian acquisition (CartesianFB ), and breath-hold Cartesian acquisition (CartesianBH )...
March 9, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29490696/imaging-features-of-fibrolamellar-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-mri
#10
Viktoria Palm, Ruofan Sheng, Philipp Mayer, Karl-Heinz Weiss, Christoph Springfeld, Arianeb Mehrabi, Thomas Longerich, Anne Katrin Berger, Hans-Ulrich Kauczor, Tim Frederik Weber
BACKGROUND: Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP. METHODS: In this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively...
March 1, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29470629/adding-ancillary-features-to-enhancement-patterns-of-hepatocellular-carcinoma-on-gadoxetic-acid-enhanced-magnetic-resonance-imaging-improves-diagnostic-performance
#11
Ji Hye Min, Young Kon Kim, Dong Hyun Sinn, Seo-Youn Choi, Woo Kyoung Jeong, Won Jae Lee, Sang Yun Ha, Soohyun Ahn, Min-Ji Kim
PURPOSE: To assess the added value of intratumoral ancillary features to conventional enhancement pattern-based diagnosis of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: A total of 773 consecutive patients with surgically resected 773 primary hepatic tumors (699 HCCs, 63 intrahepatic cholangiocarcinomas, and 11 benign nodules) who underwent gadoxetic acid-enhanced MRI were retrospectively identified...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29456716/transient-severe-motion-during-arterial-phase-in-patients-with-gadoxetic-acid-administration-can-a-five-hepatic-arterial-subphases-technique-mitigate-the-artifact
#12
Yu-Dong Xiao, Cong Ma, Jun Liu, Hua-Bing Li, Shun-Ke Zhou, Zi-Shu Zhang
Gadoxetic acid (Gd-EOB-DTPA) is a hepatocyte-specific magnetic resonance (MR) contrast agent, which has been increasingly used in recent years. However, it has been reported that Gd-EOB-DTPA related transient severe motion (TSM) is sometimes observed during the hepatic arterial phase of MR imaging, which may influence image quality. Since the hepatic arterial phase of contrast enhancement is used for the diagnosis of hepatocellular carcinoma, it is crucial to obtain a decent arterial phase imaging. The present study analyzed motion in patients receiving Gd-EOB-DTPA, comparing a single arterial phase acquisition to a five arterial phase acquisition to determine whether the multiphase acquisition was able to alleviate the TSM-related hepatic arterial MR imaging artifact...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29450712/artifacts-during-the-arterial-phase-of-gadoxetate-disodium-enhanced-mri-multiple-arterial-phases-using-view-sharing-from-two-different-vendors-versus-single-arterial-phase-imaging
#13
Ji Hye Min, Young Kon Kim, Tae Wook Kang, Woo Kyoung Jeong, Won Jae Lee, Soohyun Ahn, Na Young Hwang
OBJECTIVES: To assess the usefulness of multiple arterial phase (AP) of gadoxetic acid-enhanced MRI using view-sharing of two different vendors to reduce transient severe motion (TSM) artifact in the AP. METHODS: This retrospective study included 298 patients (mean age 63 years) who underwent gadoxetic acid MRI with multiple AP from two different vendors; either triple (subcohort A, n=174) or quadruple (subcohort B, n=124) AP. 202 patients (143 vs. 59) underwent follow-up MRI with single AP...
February 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29440620/quantification-of-hepatic-perfusion-and-hepatocyte-function-with-dynamic-gadoxetic-acid-enhanced-mri-in-patients-with-chronic-liver-disease
#14
Benjamin Leporq, Jean-Luc Daire, Catherine M Pastor, Pierre Deltenre, Christine Sempoux, Sabine Schmidt, Bernard E Van Beers
The purpose of the present study was to develop and perform initial validation of dynamic MRI enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MRI was performed at 3.0 T using a 3D time-resolved angiography sequence with stochastic trajectories during 38 min. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters...
April 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29410377/hepatobiliary-mri-as-novel-selection-criteria-in-liver-transplantation-for-hepatocellular-carcinoma
#15
Ah Yeong Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Young Kon Kim, Tae Wook Kang, Sang Yun Ha, Chul Keun Park, Gyu Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Min-Ji Kim, Insuk Sohn, Sin-Ho Jung, Seung Woon Paik, Won Jae Lee
BACKGROUND & AIMS: Hepatobiliary magnetic resonance imaging (MRI) provides additional information beyond the size and number of tumours, and may have prognostic implications. We examined whether pretransplant radiological features on MRI could be used to stratify the risk of tumour recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC). METHODS: A total of 100 patients who had received a liver transplant and who had undergone preoperative gadoxetic acid-enhanced MRI, including the hepatobiliary phase (HBP), were reviewed for tumour size, number, and morphological type (e...
June 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29353834/-evaluation-of-efficiencies-on-the-gadoxetic-acid-enhanced-mri-for-preoperative-assessment-of-liver-metastases-from-colorectal-carcinoma
#16
Kunihiro Iwata, Toshiharu Moriya, Sadahiro Nakagawa, Katsuhiko Ogasawara
1) to evaluate efficiencies of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) for preoperative assessment of liver metastases from colorectal carcinoma, and 2) to compare them with other diagnostic imaging modalities. The subjects of the analysis were outpatients with advanced colorectal cancer who are at risk of developing liver metastases (initial setting: pre-test probability=20%). At initial setting, we performed a decision analysis to calculate numbers of true positive (TP), false negative (FN), false positive (FP) and true negative (TN) test results per 1000 patients of Gd-EOB-MRI and other imaging modalities (conventional contrast agent-enhanced MRI, contrast-enhanced CT and 18 F-FDG PET/CT)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29353716/hypovascular-hypointense-nodules-in-hepatobiliary-phase-without-t2-hyperintensity-long-term-outcomes-and-added-value-of-dwi-in-predicting-hypervascular-transformation
#17
Hae Jin Yang, Ji Soo Song, Eun Jung Choi, HyeMi Choi, Jae Do Yang, Woo Sung Moon
PURPOSE: To evaluate outcomes and risk factors associated with hypervascularization in hypovascular, hepatobiliary phase (HBP) hypointense nodules (HHNs) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in chronic liver disease patients. MATERIALS AND METHODS: 222 HHNs were analyzed. Multivariate analysis with a Cox proportional hazard regression model was used. RESULTS: 41 nodules became hypervascular hepatocellular carcinoma (HCC)...
January 12, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29335868/added-value-of-ancillary-imaging-features-for-differentiating-scirrhous-hepatocellular-carcinoma-from-intrahepatic-cholangiocarcinoma-on-gadoxetic-acid-enhanced-mr-imaging
#18
Seo-Youn Choi, Young Kon Kim, Ji Hye Min, Tae Wook Kang, Woo Kyoung Jeong, Soohyun Ahn, Hojeong Won
OBJECTIVES: To determine ancillary features that help distinguish between scirrhous hepatocellular carcinoma (S-HCC) and intrahepatic cholangiocarcinoma (ICC) and investigate added value of ancillary features to enhancement pattern-based diagnosis on gadoxetic acid-enhanced MRI. METHODS: This retrospective study included 96 patients with S-HCCs and 120 patients with ICCs who underwent gadoxetic acid MRI before surgical resection. Two observers reviewed MRIs of the tumours...
January 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#19
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29260280/peri-tumoral-hyperintensity-on-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-hepatocellular-carcinomas-correlation-with-peri-tumoral-hyperplasia-and-its-pathological-features
#20
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Takahiro Komori, Kazuto Kozaka, Hiroko Ikeda, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: Peri-tumoral hyperintensity (P-hyperintensity) is occasionally seen in hepatocellular carcinoma (HCC) on the hepatobiliary (HB) phase of gadoxetic acid-enhanced MRI (EOB-MRI). A recent study reported peri-tumoral hyperplasia (P-hyperplasia) associated with over-expression of glutamine synthetase (GS) in HCC or metastatic carcinoma. The aim of this study was to analyze the correlation between P-hyperintensity on the HB phase and GS expression indicating P-hyperplasia and reveal its pathological features...
December 19, 2017: Abdominal Radiology
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