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Gadoxetic acid

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https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#1
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28076722/is-there-long-term-signal-intensity-increase-in-the-central-nervous-system-on-t1-weighted-images-after-mr-imaging-with-the-hepatospecific-contrast-agent-gadoxetic-acid-a-cross-sectional-study-in-91-patients
#2
Johannes Kahn, Helena Posch, Ingo G Steffen, Dominik Geisel, Christian Bauknecht, Thomas Liebig, Timm Denecke
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1...
January 11, 2017: Radiology
https://www.readbyqxmd.com/read/28026208/mri-of-small-hepatocellular-carcinoma-typical-features-are-less-frequent-below-a-size-cutoff-of-1-5-cm
#3
Moon Hyung Choi, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Sung Eun Rha, Chandana Lall
OBJECTIVE: The purposes of this study were to analyze MRI features of small hepatocellular carcinomas (HCCs) on the basis of size and to evaluate the difference in frequency of typical radiologic hallmarks of HCC (arterial enhancement and washout) according to the tumor size. MATERIALS AND METHODS: Enrolled were 86 patients with 110 HCCs 3 cm or smaller who underwent surgical resection or transplantation. Two radiologists reviewed gadoxetic acid-enhanced MRI features for signal intensity of T2-weighted and T1-weighted imaging, diffusion restriction, presence of arterial enhancement, washout on portal and transitional phases, and signal intensity on the hepatobiliary phase...
December 27, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28002336/the-utility-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-in-the-surveillance-for-postoperative-recurrence-of-hepatocellular-carcinoma
#4
Jung Hee Kim, Yang Won Min, Geum-Youn Gwak, Yong Han Paik, Moon Seok Choi, Joon Hyoek Lee, Kwang Cheol Koh, Seung Woon Paik
This study aimed to investigate the utility of gadoxetic acid-enhanced magnetic resonance imaging (Gd-MRI) in surveillance for recurrent hepatocellular carcinoma (HCC) after hepatectomy.This retrospective study analyzed 147 patients who underwent surveillance with alternating multidetector computed tomography (MDCT) and Gd-MRI after hepatectomy for HCC. The patients were followed-up every 3 months during the first 2 years, and every 6 months thereafter. At each visit, MDCT was performed but once a year (every 12 months), Gd-MRI was performed instead of MDCT...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27986174/avoiding-pitfalls-in-the-interpretation-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#5
Marco Dioguardi Burgio, Maxime Ronot, Luisa Paulatto, Sylvain Terraz, Valérie Vilgrain, Giuseppe Brancatelli
Gadoxetic acid is extensively used in the following 3 main clinical situations: characterization of small nodules in patients with cirrhosis, preoperative staging of liver metastases, and characterization of incidentally discovered focal liver lesions. Owing to the rapid entry of gadoxetic acid into hepatocytes, the traditional features of liver tumors are modified on magnetic resonance (MR) imaging, especially during delayed phase sequences. Thus, although the added value of gadoxetic acid for the detection and characterization of focal liver lesions is now clear, its unique pharmacokinetics as well as the presence of mimicking and atypical lesions may lead to misdiagnoses...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986173/liver-function-assessment-by-magnetic-resonance-imaging
#6
Emre Ünal, Deniz Akata, Musturay Karcaaltincaba
Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27977329/reducing-artifacts-during-arterial-phase-of-gadoxetate-disodium-enhanced-mr-imaging-dilution-method-versus-reduced-injection-rate
#7
Young Kon Kim, Wei-Chan Lin, Kyunghyun Sung, Steven S Raman, Daniel Margolis, Yaeji Lim, Seonhye Gu, David Lu
Purpose To compare two contrast material-administration protocols (dilution vs slow injection) in terms of their effectiveness in arterial phase artifact reduction at gadoxetic acid-enhanced magnetic resonance (MR) imaging. Materials and Methods This HIPAA-compliant retrospective case-controlled cohort study was approved by the institutional review board, with a waiver of informed patient consent. A total of 318 consecutive patients undergoing gadoxetic acid-enhanced MR imaging were placed into one of two subcohorts of 159 consecutive patients each: the dilution subcohort (gadoxetic acid was diluted 1:1 with saline and injected at a rate of 2...
December 15, 2016: Radiology
https://www.readbyqxmd.com/read/27957635/gadoxetic-acid-enhanced-magnetic-resonance-imaging-characteristics-of-hepatocellular-carcinoma-occurring-in-liver-transplants
#8
Mimi Kim, Tae Wook Kang, Woo Kyoung Jeong, Young Kon Kim, Seong Hyun Kim, Jong Man Kim, Dong Hyun Sinn, Min-Ji Kim, Sin-Ho Jung
OBJECTIVES: Characteristics of hepatocellular carcinoma (HCC) on magnetic resonance (MR) images were compared in patients who did or did not undergo liver transplantation (LT), and we evaluated the relationship of these findings with overall survival (OS) and time-to-tumour recurrence (TTR) after transplantation. METHODS: The enhancement pattern of gadoxetic acid-enhanced MR images of 25 patients with recurrent HCCs (LT group) and 25 surgically confirmed HCC patients in the non-transplanted (control) group were compared...
December 12, 2016: European Radiology
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#9
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27933441/multimodality-imaging-to-assess-immediate-response-following-irreversible-electroporation-in-patients-with-malignant-hepatic-tumors
#10
Katsutoshi Sugimoto, Fuminori Moriyasu, Kazuhiro Saito, Yoshiyuki Kobayashi, Takao Itoi
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual tumor in the subacute follow-up of patients with malignant hepatic tumors treated by irreversible electroporation (IRE). METHODS: We enrolled 16 patients with 21 hepatic lesions treated by IRE and examined by CEUS and CECT at 1 day after IRE and by EOB-MRI at 7 days after IRE...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27903759/intrahepatic-distant-recurrence-after-radiofrequency-ablation-for-hepatocellular-carcinoma-precursor-nodules-on-pre-procedural-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging
#11
Kyoung Doo Song, Hyunchul Rhim, Min Woo Lee, Young-Sun Kim, Tae Wook Kang
BACKGROUND: Intrahepatic distant recurrence (IDR) after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) is associated with poor overall survival outcome. PURPOSE: To evaluate the incidence and findings on pre-procedural gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) of precursor nodules for IDR after RF ablation for HCC. MATERIAL AND METHODS: This study was approved by our institutional review board. Among 343 patients treated with RF ablation for HCC between 2009 and 2011, 141 patients who underwent pre-procedural gadoxetic acid-enhanced liver MRI and experienced IDR were enrolled...
November 30, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27875000/combined-hepatocellular-cholangiocarcinoma-gadoxetic-acid-enhanced-mri-findings-correlated-with-pathologic-features-and-prognosis
#12
So Hyun Park, Seung Soo Lee, Eunsil Yu, Hyo Jeong Kang, Yangsoon Park, So Yeon Kim, So Jung Lee, Yong Moon Shin, Moon Gyu Lee
PURPOSE: To evaluate gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings of combined hepatocellular cholangiocarcinoma (cHCC-CC) with special emphasis on correlation of MRI findings with histopathologic tumor characteristics and survival outcomes after curative surgery. MATERIALS AND METHODS: Our Institutional Review Board approved this study, with a waiver of informed consent. For 82 patients (64 men, 18 women; mean age, 54.0 years; age range, 30-81) with surgically confirmed cHCC-CCs, we evaluated clinical features, histologic findings, and tumor morphologic and enhancement features on gadoxetic acid-enhanced liver MRI at 1...
November 22, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27862590/hepatic-gadoxetic-acid-uptake-as-a-measure-of-diffuse-liver-disease-where-are-we
#13
REVIEW
Ahmed Ba-Ssalamah, Nina Bastati, Andreas Wibmer, Romana Fragner, Jacqueline C Hodge, Michael Trauner, Christian J Herold, Mustafa R Bashir, Bernard E Van Beers
: MRI has emerged as the most comprehensive noninvasive diagnostic tool for focal liver lesions and diffuse hepatobiliary disorders. The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, particularly in the functional imaging of chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD). GA-enhanced MRI (GA-MRI) may help to distinguish between the two subgroups of NAFLD, simple steatosis and nonalcoholic steatohepatitis...
November 8, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27835984/qualitative-analysis-of-small-%C3%A2-2%C3%A2-cm-regenerative-nodules-dysplastic-nodules-and-well-differentiated-hccs-with-gadoxetic-acid-mri
#14
Michele Di Martino, Michele Anzidei, Fulvio Zaccagna, Luca Saba, Sandro Bosco, Massimo Rossi, Stefano Ginanni Corradini, Carlo Catalano
BACKGROUND: The characterization of small lesions in cirrhotic patients is extremely difficult due to the overlap of imaging features among different entities in the step-way of the hepatocarcinogenesis. The aim of our study was to evaluate the role of gadoxetic-acid MRI in the differentiation of small (≤2 cm) well-differentiated hepatocellular carcinomas from regenerative and dysplastic nodules. METHODS: Seventy-three cirrhotic patients, with 118 focal liver lesions (≤2 cm) were prospectively recruited...
November 11, 2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27815722/disappearing-or-residual-tiny-%C3%A2-5%C3%A2-mm-colorectal-liver-metastases-after-chemotherapy-on-gadoxetic-acid-enhanced-liver-mri-and-diffusion-weighted-imaging-is-local-treatment-required
#15
Seung Soo Kim, Kyoung Doo Song, Young Kon Kim, Hee Cheol Kim, Jung Wook Huh, Young Suk Park, Joon Oh Park, Seung Tae Kim
OBJECTIVES: To evaluate the clinical course of disappearing colorectal liver metastases (DLM) or residual tiny (≤5 mm) colorectal liver metastases (RTCLM) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in patients who had colorectal liver metastases (CLM) and received chemotherapy. METHODS: Among 137 patients who received chemotherapy for CLM and underwent gadoxetic acid-enhanced MRI and DWI between 2010 and 2012, 43 patients with 168 DLMs and 48 RTCLMs were included...
November 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27797675/intrahepatic-cholangiocarcinoma-in-patients-with-cirrhosis-differentiation-from-hepatocellular-carcinoma-by-using-gadoxetic-acid-enhanced-mr-imaging-and-dynamic-ct
#16
Sang Hyun Choi, Seung Soo Lee, So Yeon Kim, So Hyun Park, Seong Ho Park, Kang Mo Kim, Seung-Mo Hong, Eunsil Yu, Moon-Gyu Lee
Purpose To determine the imaging features at gadoxetic acid-enhanced magnetic resonance (MR) imaging of intrahepatic cholangiocarcinoma (IHCC) in a cirrhotic liver, with an emphasis on the distinction between IHCC and hepatocellular carcinoma (HCC) and on the comparison of nodule enhancement patterns between MR imaging and computed tomography (CT). Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Gadoxetic acid-enhanced MR and CT images in 72 consecutive patients (61 men; mean age, 56...
October 31, 2016: Radiology
https://www.readbyqxmd.com/read/27789027/high-flow-haemangiomas-versus-hypervascular-hepatocellular-carcinoma-showing-pseudo-washout-on-gadoxetic-acid-enhanced-hepatic-mri-value-of-diffusion-weighted-imaging-in-the-differential-diagnosis-of-small-lesions
#17
S J Nam, J-S Yu, E-S Cho, J H Kim, J-J Chung
AIM: To validate the usefulness of diffusion-weighted imaging (DWI) in the differentiation of high-flow haemangiomas showing pseudo-washout appearance on gadoxetic acid-enhanced hepatic MRI from small hypervascular hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: DWI (b=50, 800 s/mm(2)) with apparent diffusion coefficient (ADC) maps for 50 haemangiomas (6.4±2.9 mm) showing intense enhancement on arterial dominant phase imaging and hypointensity on transitional and/or hepatobiliary phase imaging during gadoxetic acid-enhanced MRI were retrospectively analysed and compared with that of 113 hypervascular HCCs (12...
October 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27780379/pre-hepatectomy-assessment-of-bile-transporter-expression-by-gadoxetic-acid-enhanced-mri-in-a-rat-model-of-liver-cirrhosis
#18
Joohyun Kim, Tae Kim, Kwan Soo Hong, Hyeyoung Moon, In-Kyung Oh, Sang Mok Lee, Mark D Hohenwalter, Michael A Zimmerman, David C Cronin, Johnny C Hong
BACKGROUND: Gadoxetic acid is a liver-specific intravenous T1 magnetic resonance (MR) contrast agent that is excreted via the hepatobiliary system. We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI). METHODS: Two groups of rats, control (n = 6) and cirrhosis (n = 12), received gadoxetic acid enhanced MRI followed by 70% hepatectomy. The change in MR signal intensity from the baseline before the contrast injection (ΔSI) was analyzed every minute for 30 min...
October 26, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27776652/biliary-tract-enhancement-in-gadoxetic-acid-enhanced-mri-correlates-with-liver-function-biomarkers
#19
Yoshifumi Noda, Satoshi Goshima, Kimihiro Kajita, Hiroshi Kawada, Nobuyuki Kawai, Hiromi Koyasu, Masayuki Matsuo, Kyongtae T Bae
PURPOSE: To evaluate the association between gadoxetic-acid-enhanced magnetic resonance (MR) imaging measurements and laboratory and clinical biomarkers of liver function and fibrosis. MATERIALS AND METHODS: One hundred thirty nine consecutive patients with suspected liver disease or liver tumor underwent gadoxetic-acid-enhanced MR imaging. MR imaging measurements during the hepatobiliary phase included biliary tract structure-to-muscle signal intensity ratio (SIR)...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27770230/added-value-of-smooth-hypointense-rim-in-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-identifying-tumour-capsule-and-diagnosing-hepatocellular-carcinoma
#20
Chansik An, Hyungjin Rhee, Kyunghwa Han, Jin-Young Choi, Young-Nyun Park, Mi-Suk Park, Myeong-Jin Kim, Sumi Park
OBJECTIVES: To examine the added value of considering smooth hypointense rim in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI as capsule appearance for diagnosing tumour capsules and hepatocellular carcinoma (HCC). METHODS: A total of 377 hepatic lesions (330 HCCs, 35 non-HCC malignancies and 12 benign) were included from 345 patients who underwent resection after MRI between January 2008 and December 2011. Two radiologists assessed the presence or absence of conventional capsule appearance and smooth hypointense rim in the HBP, and categorized each hepatic lesion according to the Liver Imaging Reporting and Data System...
October 21, 2016: European Radiology
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