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JOURNAL ARTICLE
Martin Nørmark Thesbjerg, Katrine Overgaard Poulsen, Julie Astono, Nina Aagaard Poulsen, Lotte Bach Larsen, Søren Drud-Heydary Nielsen, Allan Stensballe, Ulrik Kræmer Sundekilde
As glycosylations are difficult to analyze, their roles and effects are poorly understood. Glycosylations in human milk (HM) differ across lactation. Glycosylations can be involved in antimicrobial activities and may serve as food for beneficial microorganisms. This study aimed to identify and analyze O-linked glycans in HM by high-throughput mass spectrometry. 184 longitudinal HM samples from 66 donors from day 3 and months 1, 2, and 3 postpartum were subjected to a post-translational modification specific enrichment-based strategy using TiO2 and ZrO2 beads for O-linked glycopeptide enrichment...
April 18, 2024: International Journal of Biological Macromolecules
#2
RANDOMIZED CONTROLLED TRIAL
Nadia Raquel García-Lara, Diana Escuder-Vieco, Marta Cabrera-Lafuente, Kristin Keller, Cristina De Diego-Poncela, Concepción Jiménez-González, Raquel Núñez-Ramos, Beatriz Flores-Antón, Esperanza Escribano-Palomino, Clara Alonso-Díaz, Sara Vázquez-Román, Noelia Ureta-Velasco, Javier De La Cruz-Bértolo, Carmen Rosa Pallás-Alonso
Nosocomial infections are a frequent and serious problem in extremely low birth weight (ELBW) infants. Donor human milk (DHM) is the best alternative for feeding these babies when mother's own milk (MOM) is not available. Recently, a patented prototype of a High-Temperature Short-Time (HTST) pasteurizer adapted to a human milk bank setting showed a lesser impact on immunologic components. We designed a multicentre randomized controlled trial that investigates whether, in ELBW infants with an insufficient MOM supply, the administration of HTST pasteurized DHM reduces the incidence of confirmed catheter-associated sepsis compared to DHM pasteurized with the Holder method...
April 8, 2024: Nutrients
#3
JOURNAL ARTICLE
Dana F J Yumani, Floor H Walschot, Harrie N Lafeber, Mirjam M van Weissenbruch
Insulin-like growth factor I (IGF-I) has been suggested as an important factor in the pathogenesis of bronchopulmonary dysplasia (BPD). In turn, nutrition has been associated with IGF-I levels and could be of importance in the pathogenesis of BPD. This study aimed to explore the association between nutrition, the IGF-I axis and the occurrence of BPD. Eighty-six preterm infants (44 male, mean gestational age: 29.0 weeks (standard deviation: 1.7 weeks)) were enrolled in an observational study. Serum IGF-I (µg/L) and insulin-like growth factor binding protein 3 (IGFBP-3; mg/L) were measured at birth and at 2, 4 and 6 weeks postnatal age...
March 27, 2024: Nutrients
#4
JOURNAL ARTICLE
Bruna Gutierrez Dos Santos, Natalie Shenker, Gillian Weaver, Maryanne T Perrin
Pasteurised donor human milk is recommended for very low birthweight infants who do not have access to their mother's milk. Although the use of donor milk continues to increase, little is known about the donation experiences of milk bank donors. We aimed to describe and compare enablers, barriers and patterns of human milk donation and identify factors predicting donation volume in a convenience sample of approved milk bank donors in the United Kingdom and the United States. A cross-sectional online survey was conducted from August 2022 to December 2022...
April 12, 2024: Maternal & Child Nutrition
#5
JOURNAL ARTICLE
Marie Bendix Simonsen, Susanne Soendergaard Kappel, Lise Aunsholt, Sören Möller, Per Torp Sangild, Gitte Zachariassen
OBJECTIVES: The safety and feasibility of human milk fortification with bovine colostrum (BC) were investigated in very preterm infants (FortiColos trial, NCT03537365). The BC product contained lower calcium, phosphate, and iron levels compared to the conventional fortifier (CF). We tested whether fortification with BC plus extra phosphate was sufficient to support the infants' mineral status assessed by blood biochemistry. METHODS: In a randomised controlled trial (FortiColos, NCT03537365), mineral status was compared after fortification with BC versus CF...
April 8, 2024: Journal of Pediatric Gastroenterology and Nutrition
#6
JOURNAL ARTICLE
Tebogo Mampane, Jacqueline E Wolvaardt
Breastfeeding is a crucial public health approach that reduces infant morbidity and mortality by providing essential nutrients and antibodies, and breast milk is easily digested. Breastfeeding and donated milk serve as a preventative measure against necrotising enterocolitis. Additionally, they protect against viruses and nosocomial sepsis. When a birthing parent's own milk is unavailable, alternative enteral nutrition for preterm or low-birth-weight infants is either donor human milk (DHM) or artificial formula...
April 4, 2024: Maternal & Child Nutrition
#7
Ningjian Liang, Jeewon Koh, Bum Jin Kim, Gulustan Ozturk, Daniela Barile, David C Dallas
[This corrects the article DOI: 10.3389/fnut.2022.926814.].
2024: Frontiers in Nutrition
#8
JOURNAL ARTICLE
Georg Bach Jensen, Magnus Domellöf, Fredrik Ahlsson, Anders Elfvin, Lars Navér, Thomas Abrahamsson
BACKGROUND: Mortality and severe morbidity remain high in extremely preterm infants. Human milk-based nutrient fortifiers may prevent serious complications and death. We aimed to investigate whether supplementation with human milk-based fortifier (HMBF), as compared to bovine milk-based fortifier (BMBF), reduced the incidence of the composite outcome of necrotising enterocolitis (NEC), sepsis, and mortality in extremely preterm infants exclusively fed human milk. METHODS: In this multicentre, randomised controlled trial at 24 neonatal units in Sweden, extremely preterm infants born between gestational week 22 + 0 and 27 + 6 fed exclusively human breast milk (mother's own and/or donor milk), were randomly assigned (1:1) to receive targeted fortification with either HMBF or BMBF...
February 2024: EClinicalMedicine
#9
REVIEW
Radu Galis, Paula Trif, Diana Mudura, Jan Mazela, Mandy C Daly, Boris W Kramer, Shivashankar Diggikar
This meta-analysis assessed short-term outcomes after using human milk-derived fortifiers (HMFs) compared with bovine milk fortifiers (BMFs) in preterm infants fed an exclusive human milk (HM) diet, either mother's own milk (MOM) or donor human milk (DHM). We searched PubMed, Embase, Google Scholar, CENTRAL and CINHAL between January 2015 and August 2023 for studies reporting outcomes in infants with ≤28 weeks gestation and/or birthweight ≤ 1500 g on an exclusive human milk diet fortified with HMF versus BMF...
March 21, 2024: Nutrients
#10
JOURNAL ARTICLE
Amaia Merino-Hernández, Andrea Palacios-Bermejo, Cristina Ramos-Navarro, Silvia Caballero-Martín, Noelia González-Pacheco, Elena Rodríguez-Corrales, María Carmen Sánchez-Gómez de Orgaz, Manuel Sánchez-Luna
INTRODUCTION: Breastfeeding is one of the strategies that has been shown to be effective in preventing severe forms of bronchopulmonary dysplasia (BPD). When mother's own milk (MOM) is not available, pasteurized donor milk (DM) is the best alternative. However, the evidence is inconclusive on the difference in the incidence of bronchopulmonary dysplasia (BPD) between patients fed MOM and those fed with DM. As standard DM is usually mature pooled milk donated by mothers who have delivered their babies at term, the potential benefits of preterm milk may be lost...
March 15, 2024: Nutrients
#11
JOURNAL ARTICLE
Majid Karoobi, Amir Azimi, Hamed Zarei, Maryam Saboute, Nasrin Khalessi, Zahra Vahedi
BACKGROUND: When mother`s own milk (MOM) is unavailable or insufficient, donor milk (DM) from a human milk bank serves as an alternative feeding option. Our study sought to investigate and compare the outcomes and complications of very low birth weight (VLBW) preterm infants who receive MOM versus DM. METHODS: In this retrospective cohort study conducted between 2018 and 2022, we compared 70 VLBW preterm infants exclusively fed with DM to 70 randomly selected counterparts fed with MOM...
2024: Turkish Journal of Pediatrics
#12
COMMENT
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sánchez, Betty R Vohr, Karen J Johnson, Dianne E Herron, Abhik Das, Margaret M Crawford, Michele C Walsh, Rosemary D Higgins, Barbara J Stoll, Namisavayam Ambalavanan, Myra H Wyckoff, Carl T D'Angio, George W Bugg, Robin K Ohls, Anne Marie Reynolds, Gregory M Sokol, Abbot R Laptook, Steven L Olsen, Jessica R White, Sudarshan R Jadcherla, Monika Bajaj, Prabhu S Parimi, Barbara Schmidt, Matthew M Laughon, John Barks, Kimberley A Fisher, Anna Maria Hibbs, Myriam Peralta-Carcelen, Noah Cook, Roy J Heyne, Brenna Cavanaugh, Ira Adams-Chapman, Janell Fuller, Michelle E Hartley-McAndrew, Heidi M Harmon, Andrea F Duncan, Abbey C Hines, Howard W Kilbride, Laurie A Richards, Nathalie L Maitre, Girija Natarajan, Andrea N Trembath, Martha D Carlson, William F Malcolm, Deanne E Wilson-Costello
IMPORTANCE: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. OBJECTIVE: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk...
February 20, 2024: JAMA
#13
JOURNAL ARTICLE
Yinshuang Li, Yi Li, Yuxi Guo, Congcong Chen, Lin Yang, Qian Jiang, Peixue Ling, Shuaishuai Wang, Lei Li, Junqiang Fang
Human milk oligosaccharides (HMOs) are intricate glycans that promote healthy growth of infants and have been incorporated into infant formula as food additives. Despite their importance, the limited availability of asymmetrically branched HMOs hinders the exploration of their structure and function relationships. Herein, we report an enzymatic modular strategy for the efficient synthesis of these HMOs. The key branching enzyme for the assembly of branched HMOs, human β1,6-N-acetylglucosaminyltransferase 2 (GCNT2), was successfully expressed in Pichia pastoris for the first time...
June 1, 2024: Carbohydrate Polymers
#14
JOURNAL ARTICLE
Niamh Vickers, Anne Matthews, Gillian Paul
BACKGROUND: The multiple benefits associated with the provision of human milk exceed individual health outcomes, engendering substantial economic, societal and environmental domains. Human milk is the absolute, unparalleled source of nutrition for infants. Informal human milk sharing is a modernistic and rapidly progressing practice. No systematic review of the factors associated with this contemporary practice among donors and recipients of informal human milk sharing exists. AIM: The aim of this review was to identify, evaluate, synthesize and integrate the evidence on the factors associated with informal human milk sharing among donors and recipients...
2024: PloS One
#15
JOURNAL ARTICLE
Demet Deniz Bilgin, Nalan Karabayır
In emergencies, infants and young children are at risk of morbidity and mortality, which is increased by malnutrition. Environmental factors, food insecurity, household needs, misconceptions regarding breastfeeding, uncontrolled distribution of breast-milk substitutes, and psychological trauma make it difficult to implement proper feeding practices during disasters. Breastfeeding reduces the risk of infectious diseases and mortality in emergencies and is the safest way of feeding. Therefore, breastfeeding should be supported and promoted under all circumstances...
March 2024: Turkish archives of pediatrics
#16
JOURNAL ARTICLE
Emmanuelle Lavassani, Kate A Tauber, Jennifer B Cerone, Jennifer Ludke, Upender K Munshi
BACKGROUND: Human milk-derived fortifier (HMDF) coupled with human milk feeding in extremely premature infants reduces the adverse outcome risks of early exposure to bovine milk ingredients but may not provide enough nutrients for adequate catch-up growth compared with bovine milk-derived fortifier (BMDF). OBJECTIVE: This study aims to compare HMDF and BMDF effects on growth parameters and serum 25-hydroxy vitamin D (25OHD) levels in preterm very low birth weight (VLBW) infants during the first 8 weeks of life...
2024: Frontiers in Pediatrics
#17
JOURNAL ARTICLE
Kalaashini Ramachandran, Maznah Dahlui, Nik Daliana Nik Farid
The World Health Organisation (WHO) recommends that all babies be exclusively breastfed, stating that donor milk is the next best alternative in the absence of the mother's own milk. Milk sharing takes many forms, namely wet nursing, co-feeding, cross-feeding, and a human milk bank (HMB). However, the establishment of a human milk bank is still not widely accepted and is a debatable topic because of religious concerns in Malaysia. The aim of this study is to determine the facilitators and barriers among Malaysians towards the acceptance of an HMB...
2024: PloS One
#18
JOURNAL ARTICLE
Shoko Kozai, Ikuko Kato, Noriko Mizuno, Naho Nakamura, Hitoshi Okada, Katsumi Mizuno, Takashi Kusaka
BACKGROUND: Human milk banks have been established to provide human milk to preterm infants who are unable to obtain milk from their mothers. Donor screening methods vary, and prospective donors are commonly screened for drug and recreational substance use through behavioral screening. Although the risk of illegal drug consumption in Japan is extremely low, caffeine may be consumed unknowingly and can be found in human milk. To date, only a few reports have been conducted on the concentration of caffeine in donor milk...
February 26, 2024: Journal of Human Lactation
#19
REVIEW
Protective Characteristics of Human Breast Milk on Early Childhood Otitis Media: A Narrative Review.
Yarden Tenenbaum Weiss, Sharon Ovnat Tamir, Omer Globus, Tal Marom
Introduction: Human breast milk (HBM) contains a complex and dynamically changing variety of factors that contribute to the infant's developing immune system's ability to fight upper respiratory tract infections, including otitis media (OM). We sought to summarize the current evidence on the protective characteristics of HBM, through direct or donated feeding, toward early childhood OM. Methods: For this narrative review, we performed a literature search on OM in the context of HBM feeding in the PubMed, Embase, and Google Scholar databases, between January 1, 2008, and July 1, 2023...
February 2024: Breastfeeding Medicine
#20
JOURNAL ARTICLE
Kiersten Israel-Ballard, Emily LaRose, Kimberly Mansen
Human milk provides essential nutrition for infants and holds many health benefits for infants and mothers. When a mother's own milk is not available for her infant, the World Health Organization recommends feeding donor human milk (DHM) from a human milk banking facility. DHM is human milk produced, collected then donated to a human milk bank (HMB). HMBs serve many vital functions, including screening donor mothers, then collecting, processing, storing, and allocating DHM to recipients. The first HMB opened in 1909, and today there are more than 700 HMBs globally...
February 6, 2024: Maternal & Child Nutrition
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