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https://www.readbyqxmd.com/read/27909996/modelling-the-cost-effectiveness-of-human-milk-and-breastfeeding-in-preterm-infants-in-the-united-kingdom
#1
James Mahon, Lindsay Claxton, Hannah Wood
OBJECTIVES: To estimate the cost savings and health benefits in the UK NHS that could be achieved if human milk usage in the NICU was increased. METHODS: A systematic review established the disease areas with the strong sources of evidence of the short, medium and long-term benefits of human milk for preterm infants as opposed to the use of formula milk. The analysis assessed the economic impact of reducing rates of necrotising enterocolitis, sepsis, sudden infant death syndrome, leukaemia, otitis media, obesity and neurodevelopmental impairment...
December 2016: Health Economics Review
https://www.readbyqxmd.com/read/27836421/human-milk-is-the-feeding-strategy-to-prevent-necrotizing-enterocolitis
#2
REVIEW
Diana Maffei, Richard J Schanler
Human milk is the preferred diet for preterm infants as it protects against a multitude of NICU challenges, specifically necrotizing enterocolitis. Infants who receive greater than 50% of mother's own milk (MOM) in the 2 weeks after birth have a significantly decreased risk of NEC. An additional factor in the recent declining rates of NEC is the increased utilization of donor human milk (DHM). This creates a bridge until MOM is readily available, thus decreasing the exposure to cow milk protein. Preterm infants are susceptible to NEC due to the immaturity of their gastrointestinal and immune systems...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27831549/establishing-an-integrated-human-milk-banking-approach-to-strengthen-newborn-care
#3
A DeMarchis, K Israel-Ballard, Kimberly Amundson Mansen, C Engmann
The provision of donor human milk can significantly reduce morbidity and mortality among vulnerable infants and is recommended by the World Health Organization as the next best option when a mother's own milk is unavailable. Regulated human milk banks can meet this need, however, scale-up has been hindered by the absence of an appropriate model for resource-limited settings and a lack of policy support for human milk banks and for the operational procedures supporting them. To reduce infant mortality, human milk banking systems need to be scaled up and integrated with other components of newborn care...
November 10, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27825886/upconversion-nanoparticles-based-fret-aptasensor-for-rapid-and-ultrasenstive-bacteria-detection
#4
Birui Jin, Shurui Wang, Min Lin, Ying Jin, Shujing Zhang, Xingye Cui, Yan Gong, Ang Li, Feng Xu, Tian Jian Lu
Pathogenic bacteria cause serious harm to human health, which calls for the development of advanced detection methods. Herein, we developed a novel detection platform based on fluorescence resonance energy transfer (FRET) for rapid, ultrasensitive and specific bacteria detection, where gold nanoparticles (AuNPs, acceptor) were conjugated with aptamers while upconversion nanoparticles (UCNPs, donor) were functionalized with corresponding complementary DNA (cDNA). The spectral overlap between UCNPs fluorescence emission and AuNPs absorption enables the occurrence of FRET when hybridizing the targeted aptamer and cDNA, causing upconversion fluorescence quenching...
October 19, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27825008/effect-of-supplemental-donor-human-milk-compared-with-preterm-formula-on-neurodevelopment-of-very-low-birth-weight-infants-at-18-months-a-randomized-clinical-trial
#5
COMMENT
Deborah L O'Connor, Sharyn Gibbins, Alex Kiss, Nicole Bando, Joan Brennan-Donnan, Eugene Ng, Douglas M Campbell, Simone Vaz, Christoph Fusch, Elizabeth Asztalos, Paige Church, Edmond Kelly, Linh Ly, Alan Daneman, Sharon Unger
Importance: For many very low-birth-weight (VLBW) infants, there is insufficient mother's milk, and a supplement of pasteurized donor human milk or preterm formula is required. Awareness of the benefits of mother's milk has led to an increase in use of donor milk, despite limited data evaluating its efficacy. Objective: To determine if nutrient-enriched donor milk compared with formula, as a supplement to mother's milk, reduces neonatal morbidity, supports growth, and improves neurodevelopment in VLBW infants...
November 8, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27824996/donor-human-milk-for-very-low-birth-weight-infants
#6
EDITORIAL
Tarah T Colaizy
No abstract text is available yet for this article.
November 8, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27801820/a-comparison-of-nutritional-antioxidant-content-in-breast-milk-donor-milk-and-infant-formulas
#7
Corrine Hanson, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Ann Anderson-Berry
Human milk is the optimal food for human infants, including infants born prematurely. In the event that a mother of a hospitalized infant cannot provide breast milk, donor milk is considered an acceptable alternative. It is known that the macronutrient composition of donor milk is different than human milk, with variable fat content and protein content. However, much less is known about the micronutrient content of donor milk, including nutritional antioxidants. Samples of breast milk from 12 mothers of infants hospitalized in the Newborn Intensive Care Unit until were collected and analyzed for concentrations of nutritional antioxidants, including α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein + zeaxanthin, retinol, and α-tocopherol...
October 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27773337/donor-human-milk-update-evidence-mechanisms-and-priorities-for-research-and-practice
#8
Paula Meier, Aloka Patel, Anita Esquerra-Zwiers
No abstract text is available yet for this article.
October 20, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27755345/human-milk-processing-a-systematic-review-of-innovative-techniques-to-the-ensure-safety-and-quality-of-donor-milk
#9
Chiara Peila, Nikki E Emmerik, Marzia Giribaldi, Bernd Stahl, Joost E Ruitenberg, Ruurd M van Elburg, Guido E Moro, Enrico Bertino, Alessandra Coscia, Laura Cavallarin
OBJECTIVES: Pasteurization, performed at 62.5°C for 30 min (holder pasteurization), is currently recommended in all international human milk banks guidelines, but it affects some human milk bioactive and nutritive components. The present systematic review is aimed at critically reviewing evidence on the suitability of human milk processing techniques other than holder pasteurization, both thermal and non-thermal, to ensure microbiological safety, and on the effects of these techniques on biologically active donor milk components...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27751204/-research-advances-in-breastfeeding
#10
Xi-Hong Liu
Human breast milk is the most natural and ideal food for the baby. Breastfeeding provides benefits for maternal and child health, child immune function, growth and development, and society. The operation of human milk bank and the use of donor human milk undoubtedly provides a new way of nutrition support for the preterm infants without their own mother's milk and a new kind of treatment for other diseases. Present research on the composition of breast milk focuses on the variety and quantity of proteins, bioactive substances, probiotics and cell population...
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27711042/the-effects-of-human-milk-fortification-on-nutrients-and-milk-properties
#11
R Donovan, S G Kelly, P Prazad, P N Talaty, C Lefaiver, M L Hastings, D N Everly
OBJECTIVE: To investigate the effects of fortification and storage on nutrients and properties of various human milk (HM) types. STUDY DESIGN: Mother's own milk (MOM) and pasteurized donor human milk (DHM; n=118) were analyzed pre- and post fortification with Enfamil and Similac human milk fortifier (EHMF and SHMF) before and after 24 h of refrigerated storage. RESULTS: Milk fortified with SHMF had significantly greater osmolality, pH and lipase activity than EHMF...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27709856/the-experience-of-human-milk-banking-for-8-years-korean-perspective
#12
Hye Lim Jang, Jung Yoon Cho, Mi Jin Kim, Eun Jeong Kim, Eun Young Park, Sung Ae Park, In Young Kim, Yong Sung Choi, Chong Woo Bae, Sung Hoon Chung
Human milk banks are a solution for mothers who cannot supply their own breast milk to their sick or hospitalized infants; premature infants, in particular, are unable to receive a full volume of breast milk for numerous reasons. As of December 2015, there was only one milk bank in a university hospital in Korea. We reviewed the basic characteristics of donors and recipients, and the amounts and contamination of breast milk donated at the Human Milk Bank in Kyung Hee University Hospital at Gangdong in Korea from 2008 to 2015...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27649995/use-of-donor-milk-in-the-neonatal-intensive-care-unit
#13
Virginie de Halleux, Catherine Pieltain, Thibault Senterre, Jacques Rigo
Own mother's milk is the first choice in feeding preterm infants and provides multiple short- and long-term benefits. When it is unavailable, donor human milk is recommended as the first alternative. Donor milk undergoes processing (i.e. pasteurization) to reduce bacteriological and viral contaminants but influences its bioactive properties with potentially fewer benefits than raw milk. However, there is no clinical evidence of health benefit of raw compared to pasteurized human milk, and donor milk maintains documented advantages compared to formula...
September 16, 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27635647/organochlorine-pesticide-residues-in-human-milk-and-estimated-daily-intake-edi-for-the-infants-from-eastern-region-of-saudi-arabia
#14
M Jamal Hajjar, Ahmad Al-Salam
This study presents the level of organochlorine pesticide (OC) residues in human milk samples collected from donor mothers aged from 18 to 30 years old, from four cities in Eastern district of Saudi Arabia (Al-Hassa, Al- Khobar, Al-Jubail, and Al-Dammam). Pesticides residues were extracted from the samples and analyzed using GC-MS. The results showed that, only pp'DDE and p,pDDD, were found in 82.5% and 70% of analyzed samples respectively, the total DDT were at level of 0.37, 0.32, 0.30 and 0.46 μg/L in the four cities respectively and were far below the MRL of 50 μg/L (FAO/WHO)...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27634978/overcoming-the-limited-availability-of-human-milk-oligosaccharides-challenges-and-opportunities-for-research-and-application
#15
Lars Bode, Nikhat Contractor, Daniela Barile, Nicola Pohl, Anthony R Prudden, Geert-Jan Boons, Yong-Su Jin, Stefan Jennewein
Human milk oligosaccharides (HMOs) are complex sugars highly abundant in human milk but currently not present in infant formula. Rapidly accumulating evidence from in vitro and in vivo studies, combined with epidemiological associations and correlations, suggests that HMOs benefit infants through multiple mechanisms and in a variety of clinical contexts. Until recently, however, research on HMOs has been limited by an insufficient availability of HMOs. Most HMOs are found uniquely in human milk, and thus far it has been prohibitively tedious and expensive to isolate and synthesize them...
October 2016: Nutrition Reviews
https://www.readbyqxmd.com/read/27633108/probiotics-prebiotics-and-synbiotics-for-the-prevention-of-necrotizing-enterocolitis
#16
REVIEW
Kathene C Johnson-Henry, Thomas R Abrahamsson, Richard You Wu, Philip M Sherman
Necrotizing enterocolitis (NEC) is a devastating intestinal disease in preterm infants characterized by barrier disruption, intestinal microbial dysbiosis, and persistent inflammation of the colon, which results in high mortality rates. Current strategies used to manage this disease are not sufficient, although the use of human breast milk reduces the risk of NEC. Mother's milk is regarded as a fundamental nutritional source for neonates, but pasteurization of donor breast milk affects the composition of bioactive compounds...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27601599/comprehensive-proteomic-analysis-of-human-milk-derived-extracellular-vesicles-unveils-a-novel-functional-proteome-distinct-from-other-milk-components
#17
Martijn J C van Herwijnen, Marijke I Zonneveld, Soenita Goerdayal, Esther N M Nolte-'t Hoen, Johan Garssen, Bernd Stahl, A F Maarten Altelaar, Frank A Redegeld, Marca H M Wauben
Breast milk contains several macromolecular components with distinctive functions, whereby milk fat globules and casein micelles mainly provide nutrition to the newborn, and whey contains molecules that can stimulate the newborn's developing immune system and gastrointestinal tract. Although extracellular vesicles (EV) have been identified in breast milk, their physiological function and composition has not been addressed in detail. EV are submicron sized vehicles released by cells for intercellular communication via selectively incorporated lipids, nucleic acids, and proteins...
November 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27595621/preterm-formula-use-in-the-preterm-very-low-birth-weight-infant
#18
William W Hay, Kendra C Hendrickson
Whereas human milk is the recommended diet for all infants, preterm formulas are indicated for enteral feeding of preterm very low birth weight infants when sufficient maternal breast milk and donor human milk are not available. Feeding with preterm formulas helps to ensure consistent delivery of nutrients. The balance of risks and benefits of feeding preterm formulas versus supplemented maternal and donor breast milk for preterm infants, however, is uncertain. Numerous studies and extensive practice have shown improved growth with preterm formulas, but there is concern for increased risks of necrotizing enterocolitis, possibly from cow milk antigen in the formulas or from different gut microbiomes, increased duration of total parenteral nutrition, and increased rates of sepsis in infants receiving preterm formulas...
August 30, 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27593561/fortification-of-human-milk-for-preterm-infants
#19
Paula G Radmacher, David H Adamkin
Human milk is the preferred feeding for all infants, including those of very low birth weight (<1500 g). It has both nutritional and anti-infective properties which are especially important for infants at risk for sepsis and necrotizing enterocolitis. When maternal milk is not available or the amount produced is not sufficient to meet daily needs, donor human milk may (should) be used in its place. However, donor human milk is generally term in quality and likely has insufficient protein to promote appropriate growth...
September 1, 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27589549/necrotizing-enterocolitis-in-premature-infants-and-newborns
#20
M J Mϋller, T Paul, S Seeliger
Necrotizing enterocolitis (NEC) is the most common acquired disease of the gastrointestinal tract (GIT) in premature infants and newborns. It is defined as an ulcerative inflammation of the intestinal wall. The clinical signs of incipient NEC are often very discrete, and range from localized intestinal symptoms to generalized signs of sepsis. NEC is classified depending on its severity into disease states according to the modified Bell's Classification. Treatment of NEC ranges, depending on its severity, from a conservative therapeutic approach to surgery with resection of the affected parts of the intestine...
September 16, 2016: Journal of Neonatal-perinatal Medicine
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